Conserved Protein Domain Family
SLX9
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pfam15341: SLX9 
Ribosome biogenesis protein SLX9
SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.
Links
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Statistics
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PSSM-Id: 464660
Aligned: 132 rows
Threshold Bit Score: 43.0334
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGX51021      46 SYQPTKRA-KQQAKHT-SFLYRVAStglt---nssGVKKKLKRgRgkeaktrGKLV-TSLSSLADALPDFEgfgggndgd 119
EDP08649      29 DGPAPPLHiQKKLARKvQFLDKVSTntnt--lrtsKAGVNKKTgR-------KKAL-PDLSTLGEVLD------------ 86 
XP_007413276  64 KDRTVLPLdEKRQKRI-QEIRQVPKpys-----ksHQKRIKKKsKe------IGKI-GNLESVKTALNELNt-------- 122
GAA97759      47 PAAPSRVD-KGAERRK-ILLRKVQAstqphpysksHARRLKRKeK-------TNLAgASLSELQDALQQTTet------- 110
CCA67076      41 PGALSKKE-KRLIKRE-AFLEHIAEsqeqsvhsksAQRRAKRReK-------ERLA-ADMSEMDSVLRTVIldats---- 106
XP_002912130  10 GVSLTKKE-KLALKRE-AFLQKLELskth---sksHERRMKRKaK-------EQLA-SGMTEIQAVLAALEepqe----- 71 
EKM83788     282 QEVLTKKE-KHTQKRE-AFLQKLGAsrlp--ysksHERRQKRKaK-------EQLV-GDLNEMQTILSTIAaaedna--- 346
EMD42193     452 PITLKKKE-KQALKHE-LFVQRLEQsrsp--ysksHERRLKRKaR-------EQVA-GGMNEMKAALSAVEdal------ 513
EPT03973      56 PITLTKKE-KQALKHE-LLLRRLEAsrsp--ysrsHERRLKRRaK-------EQVA-GGLGDMQAAIEALDeem------ 117
EDR15640      58 SQVLSKKD-KQNLRRE-AFLQKFGQansp--ysksHNRRLKRKaK-------EQIA-GGLSQMQTAIAAL---------- 115

EGX51021     120 dydgeagerngvsagnkmigipglsdvnftiartRSGNiAQEGLPK-------------------KmtSLGTKRGMGKKK 180
EDP08649      87 ---------------------------------------EVSKKGSaqngaa----------ggkqakERGVSVNTAKQR 117
XP_007413276 123 ---------------------------------yIEPTiCSSTKPSnqnkss------------stkpksKKSPNLNQRA 157
GAA97759     111 ---------------------------------vPAPTpDHARQHKikqsrqhq----teplaakSpaQSTAKLTTAKRA 153
CCA67076     107 -----------------------------sqdiePTSSfTTEPSNSiakrrkgt----teangqiGesTRAKPLTKAQKK 153
XP_002912130  72 -------------------------------pqgTESKaGESGETTtasgssqt----asskslkIgaGKSEPLSKAQRK 116
EKM83788     347 ----------------------------sdepikTHGKdPNLMKADqkpevksk----pqnrgakIgeGKAAPLSKNQRQ 394
EMD42193     514 -------------------------------pvaVVEStKADVEESeatqerck----nkpkpgqIgeGKGAPLTKNQRK 558
EPT03973     118 -------------------------------ppgVVQP--SAKEDEeqtskphk----aratpgvIgeGKGAPLSKNQRK 160
EDR15640     116 -----------------------------------EKDdDPTKQPTevdqsaggpkakrntkrsmIgeGKGSTLSKSQRK 160

EGX51021     181 ERLEIAERDRFQKNVAvmmgdqtfgfgtasntstqaasaasgegsstGGAASGLQALRAFINRN 244
EDP08649     118 HHILVEESQRMQQVLKh-----------------------------pLYKKDPIAAITNHLQHT 152
XP_007413276 158 NLL-HEESSRLPKILSh-----------------------------pEFKLDGFSALRTHIKNT 191
GAA97759     154 KMI-EAESKRLPAILNh-----------------------------kAFAANPFAAIRQHAKNT 187
CCA67076     154 RAL-HTEKQRLPLILSh-----------------------------pAFLKDSFGTIRTHTSNV 187
XP_002912130 117 KAL-QLERLRQPLILTn-----------------------------pSFSSNPFSTVRLHAQNT 150
EKM83788     395 RAL-QLERFRQPLIRSn-----------------------------pEFANNPFQTIRTHAQNT 428
EMD42193     559 RAL-KTERMRIPMILAt-----------------------------pQFASNPFQTIRTHAQNT 592
EPT03973     161 RAL-QLEKMRIPMILSn-----------------------------pAFASNPFETIRTHAQNT 194
EDR15640     161 RAL-ELERLRHPLILQn-----------------------------pEFSSSPFETIRIHAQNT 194
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