Conserved Protein Domain Family
PRC2_HTH_1

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pfam18118: PRC2_HTH_1 
Polycomb repressive complex 2 tri-helical domain
This domain can be found in the Polycomb repressive complex 2 (PRC2) present in Homo sapiens. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3. This domain makes up part of the N-lobe which is involved in regulation.
Statistics
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PSSM-Id: 436286
Aligned: 13 rows
Threshold Bit Score: 120.187
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KFB43971             153 HGDK-EGSFIDDAMFVELVHALMVVTAKDA-------ADEPDGKKLHSRAsssgetidtskadeslrksklK----KTEK 220 
KZC13636             148 HGDR-ESGFMDDSIFVDLVNALAQYEKDDK-------EREHTKKGKEKEE---------------------DkdkrDSSS 198 
KZS17283             361 HGDR-EGGVIDDDIFVELVTALVPYCEEDE-------RSEPPSSLKADKA---------------------EkpdeGARC 411 
WGS:AANI:GJ11699-PA  147 HGDK-DPSFMDDAIFVELVHALMRSHSKEL-------EETVTSPSAKTETpta---------------pklK------EE 197 
KFO97549             145 HGEE-GSVLISDAVFLELVNALNQYSDEEE-------EGHNDSEVKQEDG---------------------KeelpVTKK 195 
1_pfamImport           1 HGDRgETLFFNGVIFTDLKAGLTQRSDADS-------SSAGHDANGLCQH---------------------KrsirPSRP 52  
3_pfamImport           1 HGDR-EGDFINDELFLELVTSLNQFHMQSSdlvliegTSKSGQHEER--Snkflcfcsv----ilnfyhyqKnkesSADE 73  
XP_002605895         140 HGER-EGGFINDEIFVELVRNLSELEAPKS-------SSSSEAEKADSQS---------------------TkdneEASE 190 
EEC12589             154 HGDR-DAGSVNDELFLELVHALMTYEDEPG-------TTNRTLTEANYYD---------------------IcwfrTL-- 202 
KOF99173             220 HGDR-DTKFINDDLFMELVDALWANYNDTD-------PEQRELSSPSSQN---------------------TndgiKTE- 269 
EKC36964             209 HGEK-HCNVMDNDTFVELVNSLWLNYPDPD-------VDGEEGIEHC--------------------------------- 247 
XP_009048483         179 HGER-PSNFMSDDIYIELVNNLHANYPDID-------DNGFKIIAYMAKL---------------------N----FLD- 224 
XP_003442093         176 HGDR-EGGFISDEIFKELVDALSQYSDHEE-------DEEEEASAGTVGDmt------------------gKkeeeRVMR 229  Nile t...
KFB43971             221 --NNESEtngdgter-------------ddgrqiehSTDGG------------------NDLPSAKAFPAPIIFQAISSQ 267 
KZC13636             199 ikAEVKS-----------------------------EKSSE------------------DVKTEVNPFPTMHIFNAISSM 231 
KZS17283             412 --DAVTVtk--------------------------eKPAGT------------------SGSTSAKDLPNIIVFQAIASV 445 
WGS:AANI:GJ11699-PA  198 --DEKTEtttsseptaaasssatedkeavpvaviadTKCKV------------------EKVKEKLPFPAPIIFQAISAN 257 
KFO97549             196 --RKR-------------------------------IAVEG------------------NKKCSKKRFPNDMIFTAISSM 224 
1_pfamImport          53 --C--------------------------------------------------------KESQAPRKFPSDKIFEAISSM 74  
3_pfamImport          74 --DGEDD-----------------------------NKIGD------------------ENNDAISTFPCDKIFSAIADL 104 
XP_002605895         191 --DTPDDttd------------------------slKDASG------------------TDSGSRRRFPCDQIFEAISSM 226 
EEC12589             203 --ARRPL-----------------------------RNLFP------------------EKCEEKAPSPSDFIFAAICSV 233 
KOF99173             270 -------------------------------------LKED------------------EVDKSRKTPPADIIFQSISAM 294 
EKC36964             248 -----------------------------------------------------------NQDEQKSPFPSDAIFEAISAE 268 
XP_009048483         225 --------------------------------------DDD------------------DKSFPKPTAVRDIIFKSISEV 248 
XP_003442093         230 --RSSLE-----------------------------GSEENkagsvafvrrkrrsttevKDVSSSKKIPNDKIFTAIASM 278  Nile t...
KFB43971             268 FPEQGSAEELRDKYIELTE 286 
KZC13636             232 FPDKGRPEELKEKYIELTE 250 
KZS17283             446 FPDKGTPEELRERYMELTE 464 
WGS:AANI:GJ11699-PA  258 FPDKGTPQELKEKYIELTE 276 
KFO97549             225 FPEYGFPEDMKERYRELTE 243 
1_pfamImport          75 FPDKGTAEELKEKYKELTE 93  
3_pfamImport         105 FPDKGSIDDLKEKYKELTE 123 
XP_002605895         227 FPDKGSAEELREKYKELIE 245 
EEC12589             234 FPDKRTPEELKERYRELME 252 
KOF99173             295 FPDKGTQEELKEKYIDLME 313 
EKC36964             269 FPEKGSGDDLKEKYKDLIE 287 
XP_009048483         249 FPEKGNPEELREKYRELNE 267 
XP_003442093         279 FPYKGTTEELKEKYKDLLE 297  Nile tilapia
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