5EOF


Conserved Protein Domain Family
NEMO
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pfam11577: NEMO 
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NF-kappa-B essential modulator NEMO
NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK.
Links
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Statistics
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PSSM-Id: 431942
Aligned: 7 rows
Threshold Bit Score: 69.433
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5EOF_A        16 PEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHE 82 
Q3ZC32        37 PHELLQQMRELLIENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERLYFETQSKEAKERLTALSLE 103 cattle
Q90Z16        37 PEEMVQQMKELITENNELKEAMKLHNQAMKDRYEELSIWREKQKEEREFYETKFKEAKQCLLAKCVE 103 chicken
OCA41248      31 DAEMLEQIKQLLMENNNLKETMKQMNQEMKERLEELLKRHNQHLLDLNSENELLRKELNSLREKNAT 97 
Q8VC91        44 EQGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLE 110 house mouse
XP_005162127  43 DLAGNEIVQKLITDNHQLREALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQE 109
AAH55628      19 LEETLQQMNTLIKENRDLKEALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVE 85
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