4XGC


Conserved Protein Domain Family
ORC6_CTD
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cd16075: ORC6_CTD 
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C-terminal domain of the eukaryotic origin recognition complex subunit ORC6
In eukaryotes, a complex consisting of six subunits promotes the onset of DNA replication. The 6th subunit, ORC6, does not belong to the wider AAA+ family of nucleotide hydrolases, but contains a tandemly repeated domain resembling the transcription factor TFIIB, as well as this C-terminal domain which harbors a helical segment that is responsible for interactions with the complex by binding to ORC3. Mutations in this C-terminal helix interfere with the formation of the ORC and have been linked to Meier-Gorlin syndrome, a dwarfism disorder.
Links
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Statistics
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PSSM-Id: 293922
Aligned: 28 rows
Threshold Bit Score: 40.0144
Created: 6-Nov-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ORC3-bindingMGS mutation
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ORC3-binding site [polypeptide binding site]
Evidence:
  • Structure:4XGC: A conserved helical segment of Drosophila ORC6 binds ORC3, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   ###  ##  ##  #  #   
4XGC_F         2 KESKVPSStd---mEGKLKENQNENi----KGHEAKkahkpPPEDYEIWKARMLAKAQAKLKE 57  fruit fly
XP_005181317 187 KNTMDSKLk----vDEENNDENKENgtdkgKGDTKKer-riEIEDYEKWKKRMLEMAKAKLKE 244 house fly
XP_001986374 187 KEINVAAKl-----TDKHQKKDIIV-----KNNSQKv----EIEDYEKWKSRMLASAEAKLKE 235 Drosophila grimshawi
XP_002005920 184 KDLNVTTAgv--knKFTQQEEQNGLs---kKQKSSEk---tEIEEYEKWKSRMLATAEAKLKE 238 Drosophila mojavensis
XP_004517422 189 KETAHKKQiic-igESKGDNKKAESc----VGIKRSt---aTIEDYEKWKRRMLAMAEEKLRS 243 Mediterranean fruit fly
ABR09538     185 KFNIAKKKrgrpakNAVNSDDNQEMe----ADSKEEgpteiEIEPYETWKQRMLESAYEELKQ 243 eastern spruce budworm
EHJ65065     184 KFDAVKRKvr--tsKNIQNNEQIENme--vDQRPEEkssepKIEEYEDWKKRMLEAAYRELRE 242 monarch butterfly
ADD10142     189 KRGKKEVKns---iENVEENVPMEV-----DSSKQEel-ieTFEPYEQWKKRMLDSAYSELKE 242 domestic silkworm
XP_011551928 192 KRGRPPKNvt---vEDAPNEEQMDVa----CNENKDgp--qLIETYNDWKQRILEIAYKELEE 245 diamondback moth
AAB68869     375 KWFRDLQIryd-dfDGIRYDEIIFRkl-gsMLQTTNil--vTDDQYNIWKKRIEMDLALTEPL 433 baker's yeast

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