8BW9: Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP

PDB ID: 8BW9Download
MMDB ID: 242879
PDB Deposition Date: 2022/12/6
Updated in MMDB: 2024/03
Experimental Method:
electron microscopy
Resolution: 3.32  Å
Source Organism:
Similar Structures:
Biological Unit for 8BW9: tetrameric; determined by author and by software (PISA)
Molecular Components in 8BW9
Label Count Molecule
Proteins (4 molecules)
1
Protein Aveugle
(Gene symbol: ave)
Molecule annotation
1
Connector Enhancer of KSR Protein CNK
(Gene symbol: cnk)
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase Dsor1
(Gene symbol: Dsor1)
Molecule annotation
1
KSR
(Gene symbol: ksr)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
1
TrametinibTrametinib
3
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303