2J6E: Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation

PDB ID: 2J6EDownload
MMDB ID: 45911
PDB Deposition Date: 2006/9/28
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 2J6E: hexameric; determined by author and by software (PQS)
Molecular Components in 2J6E
Label Count Molecule
Proteins (6 molecules)
2
IG Gamma-1 Chain C Region
(Gene symbol: IGHG1)
Molecule annotation
2
IGM
Molecule annotation
2
IGM
Molecule annotation
Chemicals and Non-standard biopolymers (32 molecules)
1
8
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
beta-D-galactopyranosebeta-D-galactopyranose
5
2
beta-L-fucopyranosebeta-L-fucopyranose
6
1
CADMIUM IONCADMIUM ION
7
2
ZINC IONZINC ION
8
1
CACODYLATE IONCACODYLATE ION
9
6
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
10
4
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303