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Conserved domains on  [gi|2131039084|ref|XP_044897487|]
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ataxin-2 isoform X3 [Felis catus]

Protein Classification

Sm_like and LsmAD domain-containing protein( domain architecture ID 10627809)

protein containing domains Sm_like, LsmAD, PAM2, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 92-165 4.73e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 85.30  E-value: 4.73e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039084   92 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSMESSSG--PKREEIMESILFKCSDFVVVQFK 165
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 233-294 8.57e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.57e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039084  233 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 294
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 753-1097 1.88e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  753 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 824
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  825 KVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 903
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  904 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 963
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  964 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 1043
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039084 1044 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1097
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 734-749 5.34e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


:

Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.34e-03
                           10
                   ....*....|....*.
gi 2131039084  734 RKSTLNPNAKEFNPRS 749
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 92-165 4.73e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 85.30  E-value: 4.73e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039084   92 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSMESSSG--PKREEIMESILFKCSDFVVVQFK 165
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 233-294 8.57e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.57e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039084  233 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 294
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 753-1097 1.88e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  753 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 824
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  825 KVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 903
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  904 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 963
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  964 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 1043
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039084 1044 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1097
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 734-892 4.36e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.49  E-value: 4.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  734 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 813
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  814 PVNQaktyrAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 887
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 2131039084  888 HPHVY 892
Cdd:TIGR01628  514 FPLVE 518
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 834-1098 7.87e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.95  E-value: 7.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  834 QDQHHQSTMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 908
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  909 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 981
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  982 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 1061
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 2131039084 1062 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1098
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 734-749 5.34e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.34e-03
                           10
                   ....*....|....*.
gi 2131039084  734 RKSTLNPNAKEFNPRS 749
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 92-165 4.73e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 85.30  E-value: 4.73e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039084   92 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSMESSSG--PKREEIMESILFKCSDFVVVQFK 165
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 233-294 8.57e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.57e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039084  233 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 294
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 753-1097 1.88e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  753 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 824
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  825 KVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 903
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  904 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 963
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  964 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 1043
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039084 1044 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1097
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 734-892 4.36e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.49  E-value: 4.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  734 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 813
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  814 PVNQaktyrAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 887
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 2131039084  888 HPHVY 892
Cdd:TIGR01628  514 FPLVE 518
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 834-1098 7.87e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.95  E-value: 7.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  834 QDQHHQSTMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 908
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  909 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 981
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  982 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 1061
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 2131039084 1062 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1098
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PHA03247 PHA03247
large tegument protein UL36; Provisional
 747-1130 1.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  747 PRSFSQPKPSTTPTSPRPQAQPSPSmvghqQPAPVYTQPVCFAPNmmyPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKV 826
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPL-----PPDTHAPDPPPPSPS---PAANEPDPHPPPTVPPPERPRDDPAPGRVSRP 2664

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  827 PNMPQQRQDQHHQSTMMHPASAAGPPIVATppaystqyVAYSPQQFPNQPLVQHVPHYQSqhPHVYSPVIQGNARMMAPP 906
Cdd:PHA03247  2665 RRARRLGRAAQASSPPQRPRRRAARPTVGS--------LTSLADPPPPPPTPEPAPHALV--SATPLPPGPAAARQASPA 2734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  907 AHAQP-------GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFyfAISTGSLAQQYAHPNATLHPHTPHPQPSATP 979
Cdd:PHA03247  2735 LPAAPappavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR--RLTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  980 tGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAP----------TPPSMTPASNTQSPQNSFPtaqq 1049
Cdd:PHA03247  2813 -APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrppsRSPAAKPAAPARPPVRRLA---- 2887

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084 1050 tvftihpshvQPAYTNPPHMAHVPQAHVQSGMVPSHPTAhaPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHP 1129
Cdd:PHA03247  2888 ----------RPAVSRSTESFALPPDQPERPPQPQAPPP--PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955


                   .
gi 2131039084 1130 S 1130
Cdd:PHA03247  2956 S 2956
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 751-1041 3.43e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  751 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLypipmtPMPVNQAKTYRAGKVPNM 829
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPL------QQPVQPQQPYYAPAAEQP 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  830 PQQRQDQHHQSTmmhPASAAGPPIVATPPAYSTQYVAYspqqfPNQPLVQHVPHYQSQHPHVySPVIQgnarmmaPPAHA 909
Cdd:PRK10263   416 AQQPYYAPAPEQ---PAQQPYYAPAPEQPVAGNAWQAE-----EQQSTFAPQSTYQTEQTYQ-QPAAQ-------EPLYQ 479

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  910 QPGLVsssatqygahEQTHAMYACPKLPYNKETSPSFYFaisTGSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHG 988
Cdd:PRK10263   480 QPQPV----------EQQPVVEPEPVVEETKPARPPLYY---FEEVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKA 546

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039084  989 GSHPAPSPVQHHQHQAAQALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 1041
Cdd:PRK10263   547 PSVAAVPPVEAAAAVSPLASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PHA03378 PHA03378
EBNA-3B; Provisional
 736-1091 4.54e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 4.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  736 STLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVytQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPV 815
Cdd:PHA03378   583 SQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL--RPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  816 NQAKTYraGKVPNMPQQRQDQHHqSTMMHPASAagPPIVATPPAYSTQyvAYSPQQFPnqplvqhVPHYQSQHPHVYSPV 895
Cdd:PHA03378   661 PYKPTW--TQIGHIPYQPSPTGA-NTMLPIQWA--PGTMQPPPRAPTP--MRPPAAPP-------GRAQRPAAATGRARP 726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  896 IQGNARMMAPPAHAqPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQyaHPNATlhpHTPHPQP 975
Cdd:PHA03378   727 PAAAPGRARPPAAA-PGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQ--RPRGA---PTPQPPP 800

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  976 SATPTGQQQS--QHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYH---AGLAPTPPSMTPASNTQSPQnSFPTAQQt 1050
Cdd:PHA03378   801 QAGPTSMQLMprAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERqaaAGPTPSPGSGTSDKIVQAPV-FYPPVLQ- 878

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2131039084 1051 vftihPSHV--QPAYTNPPHMAHVPQAHVQ-----SGMVPSHPTAHAP 1091
Cdd:PHA03378   879 -----PIQVmrQLGSVRAAAASTVTQAPTEytgerRGVGPMHPTDIPP 921
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 968-1121 1.37e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  968 PHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNT 1037
Cdd:PRK07764   610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAA 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084 1038 QSPQNSFPTAQQTVFTIHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQS 1110
Cdd:PRK07764   690 PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAA 769

                          170
                   ....*....|.
gi 2131039084 1111 ALQPIPVSTTA 1121
Cdd:PRK07764   770 PAAAPPPSPPS 780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 748-1124 2.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  748 RSFSQPKPSTTPTS---PRPQAQPSPsmvGHQQPAPVYTQPVCFA--PNMMY---------------PVPVSP------- 800
Cdd:PHA03247  2487 RFPFAAGAAPDPGGggpPDPDAPPAP---SRLAPAILPDEPVGEPvhPRMLTwirgleelasddagdPPPPLPpaappaa 2563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  801 ---GVQPLYPIPMTPMPVNQAKTYR--------AGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSP 869
Cdd:PHA03247  2564 pdrSVPPPRPAPRPSEPAVTSRARRpdappqsaRPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  870 QQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAH----AQPGLVSSSATQYGAHEQthamyacPKLPYNKETSPS 945
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRprrrAARPTVGSLTSLADPPPP-------PPTPEPAPHALV 2716

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  946 FYFAISTGSLAQQYAHPNATLHPHTP----HPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYH 1021
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084 1022 AGLAPTPPSMTPASNTQSPQNSFPTAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPG 1101
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876

                          410       420
                   ....*....|....*....|...
gi 2131039084 1102 GPQAALAQSALQPIPVSTTAHFP 1124
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFA 2899
PHA03247 PHA03247
large tegument protein UL36; Provisional
 740-1116 4.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  740 PNAKEFNPRSFSQPKPS------TTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFA--PNMMYPVPVSPGVQPLYPIPMT 811
Cdd:PHA03247  2601 PVDDRGDPRGPAPPSPLppdthaPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPapGRVSRPRRARRLGRAAQASSPP 2680

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  812 PMPVNQAKTYRAGKVPNMpqqrQDQHHQSTMMHPASAAGPPIVATPPAystqyVAYSPQQFPNQPLVQHVPhyqsqhPHV 891
Cdd:PHA03247  2681 QRPRRRAARPTVGSLTSL----ADPPPPPPTPEPAPHALVSATPLPPG-----PAAARQASPALPAAPAPP------AVP 2745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  892 YSPVIQGN-ARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSfyfAISTGSLAQQYAHPNATLHPHT 970
Cdd:PHA03247  2746 AGPATPGGpARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS---PWDPADPPAAVLAPAAALPPAA 2822

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039084  971 PHPQPSATPTGQQQSqhgGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPTAQqt 1050
Cdd:PHA03247  2823 SPAGPLPPPTSAQPT---APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES-- 2897

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039084 1051 vFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIP 1116
Cdd:PHA03247  2898 -FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 734-749 5.34e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.34e-03
                           10
                   ....*....|....*.
gi 2131039084  734 RKSTLNPNAKEFNPRS 749
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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