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Conserved domains on  [gi|2052103032|ref|XP_041909896|]
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GTP:AMP phosphotransferase AK3, mitochondrial isoform X4 [Corvus kubaryi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK super family cl37624
Adenylate kinase;
12-167 1.06e-67

Adenylate kinase;


The actual alignment was detected with superfamily member pfam00406:

Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 205.24  E-value: 1.06e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLDGFPRTVAQAEALDK----ECHIDTVIDLDVPFETIKCRL 86
Cdd:pfam00406  40 ELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCkNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:pfam00406 120 TGRRIHPNSGRSYHLEFNPPKVP----------------GKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKK 183


                  .
gi 2052103032 167 K 167
Cdd:pfam00406 184 K 184
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
12-167 1.06e-67

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 205.24  E-value: 1.06e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLDGFPRTVAQAEALDK----ECHIDTVIDLDVPFETIKCRL 86
Cdd:pfam00406  40 ELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCkNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:pfam00406 120 TGRRIHPNSGRSYHLEFNPPKVP----------------GKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKK 183


                  .
gi 2052103032 167 K 167
Cdd:pfam00406 184 K 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 12-176 6.22e-66

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 201.89  E-value: 6.22e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCR 85
Cdd:COG0563    44 ELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDcANGFILDGFPRTVAQAEALDEllaelGIKLDAVIELDVDDEELVER 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  86 LTARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYR 165
Cdd:COG0563   124 LSGRRVCPNCGATYHVKFNPPKVE----------------GVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYYR 187

                         170
                  ....*....|.
gi 2052103032 166 KKGLLKSFSGT 176
Cdd:COG0563   188 KKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 12-190 8.00e-65

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 199.22  E-value: 8.00e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALDKECH-----IDTVIDLDVPFETIKCR 85
Cdd:PRK00279   44 ELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDcKNGFLLDGFPRTIPQAEALDEMLKelgikLDAVIEIDVPDEELVER 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  86 LTARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYR 165
Cdd:PRK00279  124 LSGRRICPACGRTYHVKFNPPKVE----------------GKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYK 187

                         170       180
                  ....*....|....*....|....*.
gi 2052103032 166 KKGLLKSFSGTET-NKIWPHIYAFLQ 190
Cdd:PRK00279  188 KKGKLKKIDGTGSiDEVFADILKALG 213
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 3-190 3.92e-62

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 192.06  E-value: 3.92e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032   3 REVITQRIlEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN--WLLDGFPRTVAQAEALDK--ECHIDTVIDLDVP 78
Cdd:TIGR01351  35 RAEIKAGT-PLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEngFILDGFPRTLSQAEALDAllEEPIDAVIELDVP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  79 FETIKCRLTARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTK 158
Cdd:TIGR01351 114 DEELVERLSGRRICPSCGRVYHLKFNPPKVP----------------GCDDCTGELLVQREDDTEEVVKKRLEVYKEQTE 177

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2052103032 159 PVLEYYRKKGLLKSFSGT-ETNKIWPHIYAFLQ 190
Cdd:TIGR01351 178 PLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 12-178 2.50e-55

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 174.35  E-value: 2.50e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-WLLDGFPRTVAQAEALDKECH----IDTVIDLDVPFETIKCRL 86
Cdd:cd01428    43 ELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKgFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIHPASGRVYNLefsppkvqtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:cd01428   123 LGRRICPVSGRVYHL------------------------GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYYKK 178

                         170
                  ....*....|..
gi 2052103032 167 KGLLKSFSGTET 178
Cdd:cd01428   179 KGKLVEIDGSGD 190
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
12-167 1.06e-67

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 205.24  E-value: 1.06e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLDGFPRTVAQAEALDK----ECHIDTVIDLDVPFETIKCRL 86
Cdd:pfam00406  40 ELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCkNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:pfam00406 120 TGRRIHPNSGRSYHLEFNPPKVP----------------GKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKK 183


                  .
gi 2052103032 167 K 167
Cdd:pfam00406 184 K 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 12-176 6.22e-66

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 201.89  E-value: 6.22e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCR 85
Cdd:COG0563    44 ELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDcANGFILDGFPRTVAQAEALDEllaelGIKLDAVIELDVDDEELVER 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  86 LTARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYR 165
Cdd:COG0563   124 LSGRRVCPNCGATYHVKFNPPKVE----------------GVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYYR 187

                         170
                  ....*....|.
gi 2052103032 166 KKGLLKSFSGT 176
Cdd:COG0563   188 KKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 12-190 8.00e-65

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 199.22  E-value: 8.00e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALDKECH-----IDTVIDLDVPFETIKCR 85
Cdd:PRK00279   44 ELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDcKNGFLLDGFPRTIPQAEALDEMLKelgikLDAVIEIDVPDEELVER 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  86 LTARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYR 165
Cdd:PRK00279  124 LSGRRICPACGRTYHVKFNPPKVE----------------GKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYK 187

                         170       180
                  ....*....|....*....|....*.
gi 2052103032 166 KKGLLKSFSGTET-NKIWPHIYAFLQ 190
Cdd:PRK00279  188 KKGKLKKIDGTGSiDEVFADILKALG 213
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 3-190 3.92e-62

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 192.06  E-value: 3.92e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032   3 REVITQRIlEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN--WLLDGFPRTVAQAEALDK--ECHIDTVIDLDVP 78
Cdd:TIGR01351  35 RAEIKAGT-PLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEngFILDGFPRTLSQAEALDAllEEPIDAVIELDVP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  79 FETIKCRLTARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTK 158
Cdd:TIGR01351 114 DEELVERLSGRRICPSCGRVYHLKFNPPKVP----------------GCDDCTGELLVQREDDTEEVVKKRLEVYKEQTE 177

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2052103032 159 PVLEYYRKKGLLKSFSGT-ETNKIWPHIYAFLQ 190
Cdd:TIGR01351 178 PLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 12-178 2.50e-55

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 174.35  E-value: 2.50e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-WLLDGFPRTVAQAEALDKECH----IDTVIDLDVPFETIKCRL 86
Cdd:cd01428    43 ELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKgFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIHPASGRVYNLefsppkvqtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:cd01428   123 LGRRICPVSGRVYHL------------------------GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYYKK 178

                         170
                  ....*....|..
gi 2052103032 167 KGLLKSFSGTET 178
Cdd:cd01428   179 KGKLVEIDGSGD 190
PLN02674 PLN02674
adenylate kinase
 13-170 3.63e-41

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 139.64  E-value: 3.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  13 VGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALD-----KECHIDTVIDLDVPFETIKCRL 86
Cdd:PLN02674   76 LGIKAKEAMDKGELVSDDLVVGIIDEAMKKPScQKGFILDGFPRTVVQAQKLDemlakQGAKIDKVLNFAIDDAILEERI 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIHPASGRVYNLEFSPPKVQtvlpesqeltfkirtqGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:PLN02674  156 TGRWIHPSSGRTYHTKFAPPKVP----------------GVDDVTGEPLIQRKDDTAAVLKSRLEAFHKQTEPVIDYYAK 219


                  ....
gi 2052103032 167 KGLL 170
Cdd:PLN02674  220 KGVV 223
PRK14530 PRK14530
adenylate kinase; Provisional
 18-193 1.25e-30

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 111.80  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  18 KSYIDQGKLIPDDIMTQLMLNELKGLDRYnwLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPASGR 97
Cdd:PRK14530   57 GEYMDAGELVPDAVVNEIVEEALSDADGF--VLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  98 VYNLEFSPPKvqtvlpesqeltfkirTQGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTE 177
Cdd:PRK14530  135 NYHVEFNQPE----------------EEGVCDECGGELIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQ 198

                         170
                  ....*....|....*..
gi 2052103032 178 T-NKIWPHIYAFLQTRL 193
Cdd:PRK14530  199 TpDEVWADIQDAIDDAT 215
adk PRK02496
adenylate kinase; Provisional
 3-178 3.19e-23

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 91.35  E-value: 3.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032   3 REVITQRIlEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-WLLDGFPRTVAQAEALDK---ECH--IDTVIDLD 76
Cdd:PRK02496   37 RQAIKEQT-PLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANgWILDGFPRKVTQAAFLDEllqEIGqsGERVVNLD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  77 VPFETIKCRLTARwihpasgrvynlefsppkvqtvlpesqeltfkirtqgidditgeplvQRDDDKPETVSKRLQAYDAQ 156
Cdd:PRK02496  116 VPDDVVVERLLAR-----------------------------------------------GRKDDTEEVIRRRLEVYREQ 148

                         170       180
                  ....*....|....*....|..
gi 2052103032 157 TKPVLEYYRKKGLLKSFSGTET 178
Cdd:PRK02496  149 TAPLIDYYRDRQKLLTIDGNQS 170
PLN02842 PLN02842
nucleotide kinase
 12-164 1.11e-22

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 94.54  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD--RYNWLLDGFPRTVAQAEALDK-ECHIDTVIDLDVPFETIKCRLTA 88
Cdd:PLN02842   41 DIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDakEKGWLLDGYPRSFAQAQSLEKlKIRPDIFILLDVPDEILIDRCVG 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052103032  89 RWIHPASGRVYNLEFSPpkvqtvlPESQELtfKIRtqgidditgepLVQRDDDKPETVSKRLQAYDAQTKPVLEYY 164
Cdd:PLN02842  121 RRLDPVTGKIYHIKNFP-------PESEEI--KAR-----------LITRPDDTEEKVKARLQIYKKNAEAILSTY 176
PLN02459 PLN02459
probable adenylate kinase
 18-173 1.17e-20

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 86.44  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  18 KSYIDQGKLIPDDIMTQLMLNELK-GLDR--YNWLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPA 94
Cdd:PLN02459   79 KEIVNQGKLVPDEIIFSLLSKRLEaGEEEgeSGFILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSE 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  95 SGRVYNL--------EFSPPKVQTVLPESQELTFKirtqgidditgepLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:PLN02459  159 CGKNFNVadidlkgeDGRPGIVMPPLLPPPECASK-------------LITRADDTEEVVKARLRVYKEESQPVEDFYRK 225


                  ....*..
gi 2052103032 167 KGLLKSF 173
Cdd:PLN02459  226 RGKLLEF 232
PRK14526 PRK14526
adenylate kinase; Provisional
 18-178 1.27e-20

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 85.29  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  18 KSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPASG 96
Cdd:PRK14526   50 KQIVENGQLVPDSITIKIVEDKINTIKnNDNFILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  97 RVYNLefsppkvqtvlpesqeLTFKIRTQGIDDITGEPLVQRDDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGT 176
Cdd:PRK14526  130 NIFNI----------------YTLPTKEKGICDVCKGDLYQRKDDKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDAS 193


                  ..
gi 2052103032 177 ET 178
Cdd:PRK14526  194 KD 195
PRK14532 PRK14532
adenylate kinase; Provisional
 12-175 6.97e-20

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 82.95  E-value: 6.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLM---LNELKGLDryNWLLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIK 83
Cdd:PRK14532   44 ELGQRVKGIMDRGELVSDEIVIALIeerLPEAEAAG--GAIFDGFPRTVAQAEALDKmlasrGQKIDVVIRLKVDDEALI 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  84 CRLTARWihpasgrvynlefsppkvqtvlpesqeltfkiRTQGidditgeplvqRDDDKPETVSKRLQAYDAQTKPVLEY 163
Cdd:PRK14532  122 ERIVKRF--------------------------------EEQG-----------RPDDNPEVFVTRLDAYNAQTAPLLPY 158

                         170
                  ....*....|..
gi 2052103032 164 YRKKGLLKSFSG 175
Cdd:PRK14532  159 YAGQGKLTEVDG 170
PRK14527 PRK14527
adenylate kinase; Provisional
 12-178 7.21e-20

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 82.92  E-value: 7.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNWLLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCRL 86
Cdd:PRK14527   50 ELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRVIFDGFPRTLAQAEALDRlleelGARLLAVVLLEVPDEELIRRI 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARwihpasgrvynlefsppkvqtvlpESQEltfkirtqgidditgeplvQRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:PRK14527  130 VER------------------------ARQE-------------------GRSDDNEETVRRRQQVYREQTQPLVDYYEA 166

                         170
                  ....*....|..
gi 2052103032 167 KGLLKSFSGTET 178
Cdd:PRK14527  167 RGHLKRVDGLGT 178
PRK14528 PRK14528
adenylate kinase; Provisional
 13-178 1.80e-19

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 81.98  E-value: 1.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  13 VGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-WLLDGFPRTVAQAEALD---KECH--IDTVIDLDVPFETIKCRL 86
Cdd:PRK14528   46 MGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNgFLLDGFPRTVEQADALDallKNEGksIDKAINLEVPDGELLKRL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARWIhpasgrvynlefsppkvqtvlpesqeltfkirtqgiddITGeplvqRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:PRK14528  126 LGRAE--------------------------------------IEG-----RADDNEATIKNRLDNYNKKTLPLLDFYAA 162

                         170
                  ....*....|..
gi 2052103032 167 KGLLKSFSGTET 178
Cdd:PRK14528  163 QKKLSQVNGVGS 174
PRK13808 PRK13808
adenylate kinase; Provisional
 13-175 1.75e-18

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 81.86  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  13 VGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-WLLDGFPRTVAQAEALD-----KECHIDTVIDLDVPfetiKCRL 86
Cdd:PRK13808   45 VGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANgFILDGFPRTVPQAEALDallkdKQLKLDAVVELRVN----EGAL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  87 TARwihpasgrvynlefsppkVQTVLPESQEltfkirtqgiddiTGEPLvqRDDDKPETVSKRLQAYDAQTKPVLEYYRK 166
Cdd:PRK13808  121 LAR------------------VETRVAEMRA-------------RGEEV--RADDTPEVLAKRLASYRAQTEPLVHYYSE 167


                  ....*....
gi 2052103032 167 KGLLKSFSG 175
Cdd:PRK13808  168 KRKLLTVDG 176
PRK14529 PRK14529
adenylate kinase; Provisional
 12-89 9.14e-18

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 78.22  E-value: 9.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNWLLDGFPRTVAQAEALDKECH-----IDTVIDLDVPFETIKCRL 86
Cdd:PRK14529   44 ELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLDGFPRNKVQAEKLWEALQkegmkLDYVIEILLPREVAKNRI 123


                  ...
gi 2052103032  87 TAR 89
Cdd:PRK14529  124 MGR 126
PRK14531 PRK14531
adenylate kinase; Provisional
 12-172 1.41e-17

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 76.77  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNWLLDGFPRTVAQAEALDKechidTVIDLDVPFETIkcrltarwi 91
Cdd:PRK14531   46 ALGQEAEAVMNRGELVSDALVLAIVESQLKALNSGGWLLDGFPRTVAQAEALEP-----LLEELKQPIEAV--------- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  92 hpasgrvynlefsppkvqtVLPESQeltfkirtqgiDDITGEPLVQ--RDDDKPETVSKRLQAYDAQTKPVLEYYRKKGL 169
Cdd:PRK14531  112 -------------------VLLELD-----------DAVLIERLLArgRADDNEAVIRNRLEVYREKTAPLIDHYRQRGL 161


                  ...
gi 2052103032 170 LKS 172
Cdd:PRK14531  162 LQS 164
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 3-176 1.58e-15

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 71.25  E-value: 1.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032   3 REVITQRILEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLDGFPRTVAQAEA----LDKECHIDTVIDLDV 77
Cdd:TIGR01359  35 RAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSsKKFLIDGFPRNEENLEAweklMDNKVNFKFVLFFDC 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  78 PFETIKCRLTARwiHPASGRVynlefsppkvqtvlpesqeltfkirtqgidditgeplvqrdDDKPETVSKRLQAYDAQT 157
Cdd:TIGR01359 115 PEETMIKRLLKR--GQTSGRV-----------------------------------------DDNIETLKKRFRTYNEET 151

                         170
                  ....*....|....*....
gi 2052103032 158 KPVLEYYRKKGLLKSFSGT 176
Cdd:TIGR01359 152 LPIIEHFENKGKVKEINAE 170
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 13-193 2.11e-15

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 71.75  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  13 VGILAKSYIDQGKLIPDDIMTQLMLNEL-KGLDRY--NWLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTAR 89
Cdd:PTZ00088   51 IGKEIQKVVTSGNLVPDNLVIAIVKDEIaKVTDDCfkGFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGR 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  90 WIHPASGRVYN---LEFSPPKVQTVLPEsqeltfkirtQGIDDITGEP-LVQRDDDKPETVSKRLQAYDAQTKPVLEYYR 165
Cdd:PTZ00088  131 RICNTCNRNFNiahIRSDPYDMPPILPP----------ADCEGCKGNPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFK 200

                         170       180
                  ....*....|....*....|....*....
gi 2052103032 166 KKGL-LKSFSGTETNKIWPHIYAFLQTRL 193
Cdd:PTZ00088  201 NENCnLVDFEITRGLRDFDDFYRIVLQRL 229
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 89-140 2.77e-13

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 61.32  E-value: 2.77e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2052103032  89 RWIHPASGRVYNLEFSPPKVqtvlpesqeltfkirtQGIDDITGEPLVQRDD 140
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKV----------------EGVCDVCGGELVQRDD 36
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 12-170 8.56e-10

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 55.98  E-value: 8.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  12 EVGILAKSYIDQGKLIPDDIMTQlMLNE--LKGLDRYN-WLLDGFPRTVAQAEALDKEC-HIDTVIDLDVPFETIKCRLT 87
Cdd:TIGR01360  47 ERGKQLQAIMESGDLVPLDTVLD-LLKDamVAALGTSKgFLIDGYPREVKQGEEFERRIgPPTLVLYFDCSEDTMVKRLL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  88 ARwiHPASGRVynlefsppkvqtvlpesqeltfkirtqgidditgeplvqrdDDKPETVSKRLQAYDAQTKPVLEYYRKK 167
Cdd:TIGR01360 126 KR--AETSGRV-----------------------------------------DDNEKTIKKRLETYYKATEPVIAYYETK 162


                  ...
gi 2052103032 168 GLL 170
Cdd:TIGR01360 163 GKL 165
PLN02200 PLN02200
adenylate kinase family protein
 21-185 1.32e-07

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 50.28  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  21 IDQGKLIPDDIMTQLMLNELKGLDRYNWLLDGFPRTVAQAEALDK--ECHIDTVIDLDVPFETIKCRLTARwihpASGRV 98
Cdd:PLN02200   96 IKEGKIVPSEVTVKLIQKEMESSDNNKFLIDGFPRTEENRIAFERiiGAEPNVVLFFDCPEEEMVKRVLNR----NQGRV 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032  99 ynlefsppkvqtvlpesqeltfkirtqgidditgeplvqrdDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 178
Cdd:PLN02200  172 -----------------------------------------DDNIDTIKKRLKVFNALNLPVIDYYSKKGKLYTINAVGT 210


                  ....*...
gi 2052103032 179 -NKIWPHI 185
Cdd:PLN02200  211 vDEIFEQV 218
AAA_17 pfam13207
AAA domain;
3-102 1.12e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 46.08  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103032   3 REVITQRILevgILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDGFPRTVAQAEALD-------KECHIDTVID 74
Cdd:pfam13207  31 REEAKERGL---VEDRDEMRKLPLEPQKELQKLAAERIAEEAgEGGVIVDGHPRIKTPAGYLPglpvevlRELKPDAIIL 107

                          90       100
                  ....*....|....*....|....*....
gi 2052103032  75 LDVPFETIKCRLTARwihPASGRVY-NLE 102
Cdd:pfam13207 108 LEADPEEILERRLKD---RTRGRDDdSEE 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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