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Conserved domains on  [gi|2052103030|ref|XP_041909895|]
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GTP:AMP phosphotransferase AK3, mitochondrial isoform X3 [Corvus kubaryi]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11995178)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
11-189 2.07e-97

Adenylate kinase;


:

Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 281.50  E-value: 2.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLD 89
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCkNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  90 GFPRTVAQAEALDK----ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDDDKP 165
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 2052103030 166 ETVSKRLQAYDAQTKPVLEYYRKK 189
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
11-189 2.07e-97

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 281.50  E-value: 2.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLD 89
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCkNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  90 GFPRTVAQAEALDK----ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDDDKP 165
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 2052103030 166 ETVSKRLQAYDAQTKPVLEYYRKK 189
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 8-198 1.52e-96

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 280.48  E-value: 1.52e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNW 86
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDcANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRD 161
Cdd:COG0563    82 ILDGFPRTVAQAEALDEllaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2052103030 162 DDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGT 198
Cdd:COG0563   162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 7-212 9.92e-95

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 275.88  E-value: 9.92e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   7 LRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYN 85
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDcKNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  86 WLLDGFPRTVAQAEALDKECH-----IDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQR 160
Cdd:PRK00279   81 FLLDGFPRTIPQAEALDEMLKelgikLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2052103030 161 DDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET-NKIWPHIYAFLQ 212
Cdd:PRK00279  161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSiDEVFADILKALG 213
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 8-212 8.17e-93

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 270.64  E-value: 8.17e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-- 85
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  86 WLLDGFPRTVAQAEALDK--ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDDD 163
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDAllEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2052103030 164 KPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGT-ETNKIWPHIYAFLQ 212
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 8-200 7.60e-87

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 255.24  E-value: 7.60e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-W 86
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKgF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDKECH----IDTVIDLDVPFETIKCRLTARWIHPASGRVYNLefsppkvqGIDDITGEPLVQRDD 162
Cdd:cd01428    81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSD 152

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2052103030 163 DKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 200
Cdd:cd01428   153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
11-189 2.07e-97

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 281.50  E-value: 2.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLLD 89
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCkNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  90 GFPRTVAQAEALDK----ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDDDKP 165
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 2052103030 166 ETVSKRLQAYDAQTKPVLEYYRKK 189
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 8-198 1.52e-96

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 280.48  E-value: 1.52e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNW 86
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDcANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRD 161
Cdd:COG0563    82 ILDGFPRTVAQAEALDEllaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2052103030 162 DDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGT 198
Cdd:COG0563   162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 7-212 9.92e-95

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 275.88  E-value: 9.92e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   7 LRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYN 85
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDcKNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  86 WLLDGFPRTVAQAEALDKECH-----IDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQR 160
Cdd:PRK00279   81 FLLDGFPRTIPQAEALDEMLKelgikLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2052103030 161 DDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET-NKIWPHIYAFLQ 212
Cdd:PRK00279  161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSiDEVFADILKALG 213
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 8-212 8.17e-93

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 270.64  E-value: 8.17e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-- 85
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  86 WLLDGFPRTVAQAEALDK--ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDDD 163
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDAllEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2052103030 164 KPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGT-ETNKIWPHIYAFLQ 212
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 8-200 7.60e-87

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 255.24  E-value: 7.60e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-W 86
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKgF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDKECH----IDTVIDLDVPFETIKCRLTARWIHPASGRVYNLefsppkvqGIDDITGEPLVQRDD 162
Cdd:cd01428    81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSD 152

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2052103030 163 DKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 200
Cdd:cd01428   153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
PLN02674 PLN02674
adenylate kinase
 5-192 2.69e-61

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 192.02  E-value: 2.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   5 PLLRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-R 83
Cdd:PLN02674   30 PDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPScQ 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  84 YNWLLDGFPRTVAQAEALD-----KECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLV 158
Cdd:PLN02674  110 KGFILDGFPRTVVQAQKLDemlakQGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLI 189

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2052103030 159 QRDDDKPETVSKRLQAYDAQTKPVLEYYRKKGLL 192
Cdd:PLN02674  190 QRKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVV 223
PRK14530 PRK14530
adenylate kinase; Provisional
 8-215 1.90e-51

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 165.73  E-value: 1.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKK-----TEVGIlAKSYIDQGKLIPDDIMTQLMLNELKGLD 82
Cdd:PRK14530    5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMDisdmdTEYDT-PGEYMDAGELVPDAVVNEIVEEALSDAD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  83 RYnwLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDD 162
Cdd:PRK14530   84 GF--VLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGELIQRDD 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2052103030 163 DKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET-NKIWPHIYAFLQTRL 215
Cdd:PRK14530  162 DTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVWADIQDAIDDAT 215
adk PRK02496
adenylate kinase; Provisional
 8-200 5.05e-44

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 146.05  E-value: 5.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-W 86
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANgW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDK---ECH--IDTVIDLDVPFETIKCRLTARwihpasgrvynlefsppkvqgidditgeplvQRD 161
Cdd:PRK02496   83 ILDGFPRKVTQAAFLDEllqEIGqsGERVVNLDVPDDVVVERLLAR-------------------------------GRK 131

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2052103030 162 DDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 200
Cdd:PRK02496  132 DDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQS 170
PRK14526 PRK14526
adenylate kinase; Provisional
 7-200 5.18e-41

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 139.22  E-value: 5.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   7 LRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYN 85
Cdd:PRK14526    1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKnNDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  86 WLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDDDKP 165
Cdd:PRK14526   81 FILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKE 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2052103030 166 ETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 200
Cdd:PRK14526  161 ESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKD 195
PRK14527 PRK14527
adenylate kinase; Provisional
 8-200 8.08e-40

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 135.30  E-value: 8.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVI-MGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNW 86
Cdd:PRK14527    7 KVVIfLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCRLTARwihpasGRvynlefsppkvqgidditgepLVQRD 161
Cdd:PRK14527   87 IFDGFPRTLAQAEALDRlleelGARLLAVVLLEVPDEELIRRIVER------AR---------------------QEGRS 139

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2052103030 162 DDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 200
Cdd:PRK14527  140 DDNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGT 178
PRK14531 PRK14531
adenylate kinase; Provisional
 8-194 2.78e-39

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 133.78  E-value: 2.78e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNWL 87
Cdd:PRK14531    4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSGGWL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  88 LDGFPRTVAQAEALDKechidTVIDLDVPFETikcrltarwihpasgrVYNLEFSppkvqgiDDITGEPLVQ--RDDDKP 165
Cdd:PRK14531   84 LDGFPRTVAQAEALEP-----LLEELKQPIEA----------------VVLLELD-------DAVLIERLLArgRADDNE 135

                         170       180
                  ....*....|....*....|....*....
gi 2052103030 166 ETVSKRLQAYDAQTKPVLEYYRKKGLLKS 194
Cdd:PRK14531  136 AVIRNRLEVYREKTAPLIDHYRQRGLLQS 164
PLN02842 PLN02842
nucleotide kinase
 10-186 5.58e-38

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 137.68  E-value: 5.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLD--RYNWL 87
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDakEKGWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  88 LDGFPRTVAQAEALDK-ECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLEFSPPKvqgiDDITGEPLVQRDDDKPE 166
Cdd:PLN02842   81 LDGYPRSFAQAQSLEKlKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----SEEIKARLITRPDDTEE 156

                         170       180
                  ....*....|....*....|
gi 2052103030 167 TVSKRLQAYDAQTKPVLEYY 186
Cdd:PLN02842  157 KVKARLQIYKKNAEAILSTY 176
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 11-198 1.15e-37

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 129.80  E-value: 1.15e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKK-TEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDR-YNWLL 88
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSsKKFLI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  89 DGFPRTVAQAEA----LDKECHIDTVIDLDVPFETIKCRLTARwiHPASGRVynlefsppkvqgidditgeplvqrdDDK 164
Cdd:TIGR01359  84 DGFPRNEENLEAweklMDNKVNFKFVLFFDCPEETMIKRLLKR--GQTSGRV-------------------------DDN 136

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2052103030 165 PETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGT 198
Cdd:TIGR01359 137 IETLKKRFRTYNEETLPIIEHFENKGKVKEINAE 170
PRK14532 PRK14532
adenylate kinase; Provisional
 10-197 4.74e-37

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 128.02  E-value: 4.74e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLM---LNELKGLDryNW 86
Cdd:PRK14532    4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIeerLPEAEAAG--GA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDK-----ECHIDTVIDLDVPFETIKCRLTARWihpasgrvynlefsppKVQGidditgeplvqRD 161
Cdd:PRK14532   82 IFDGFPRTVAQAEALDKmlasrGQKIDVVIRLKVDDEALIERIVKRF----------------EEQG-----------RP 134

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2052103030 162 DDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSG 197
Cdd:PRK14532  135 DDNPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDG 170
PLN02459 PLN02459
probable adenylate kinase
 10-195 6.85e-37

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 129.97  E-value: 6.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELK-GLDR--YNW 86
Cdd:PLN02459   33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEaGEEEgeSGF 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNLE----FSPPKVQGIDDITGEP------ 156
Cdd:PLN02459  113 ILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVAdidlKGEDGRPGIVMPPLLPppecas 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2052103030 157 -LVQRDDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSF 195
Cdd:PLN02459  193 kLITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
PRK14528 PRK14528
adenylate kinase; Provisional
 8-200 4.39e-36

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 125.51  E-value: 4.39e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   8 RAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN-W 86
Cdd:PRK14528    3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNgF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  87 LLDGFPRTVAQAEALD---KECH--IDTVIDLDVPFETIKCRLTARWIhpasgrvynlefsppkVQGidditgeplvqRD 161
Cdd:PRK14528   83 LLDGFPRTVEQADALDallKNEGksIDKAINLEVPDGELLKRLLGRAE----------------IEG-----------RA 135

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2052103030 162 DDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET 200
Cdd:PRK14528  136 DDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGS 174
PRK13808 PRK13808
adenylate kinase; Provisional
 7-197 1.44e-34

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 125.77  E-value: 1.44e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   7 LRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYN- 85
Cdd:PRK13808    1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  86 WLLDGFPRTVAQAEALD-----KECHIDTVIDLDVPFETIKCRLTARwihPASGRVynlefsppkvqgiddiTGEPLvqR 160
Cdd:PRK13808   81 FILDGFPRTVPQAEALDallkdKQLKLDAVVELRVNEGALLARVETR---VAEMRA----------------RGEEV--R 139

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2052103030 161 DDDKPETVSKRLQAYDAQTKPVLEYYRKKGLLKSFSG 197
Cdd:PRK13808  140 ADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVDG 176
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 7-215 7.65e-32

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 116.05  E-value: 7.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   7 LRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNEL-KGLDRY- 84
Cdd:PTZ00088    7 LKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIaKVTDDCf 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  85 -NWLLDGFPRTVAQAEALDKECHIDTVIDLDVPFETIKCRLTARWIHPASGRVYNL------EFSPPKV---QGIDDITG 154
Cdd:PTZ00088   87 kGFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIahirsdPYDMPPIlppADCEGCKG 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2052103030 155 EP-LVQRDDDKPETVSKRLQAYDAQTKPVLEYYRKKGL-LKSFSGTETNKIWPHIYAFLQTRL 215
Cdd:PTZ00088  167 NPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENCnLVDFEITRGLRDFDDFYRIVLQRL 229
PRK14529 PRK14529
adenylate kinase; Provisional
 10-175 2.21e-31

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 114.43  E-value: 2.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNWLLD 89
Cdd:PRK14529    4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  90 GFPRTVAQAEALD-----KECHIDTVIDLDVPFETIKCRLTARWI------HPAsgrvyNLEFSPPKVQG-IDDITGEPL 157
Cdd:PRK14529   84 GFPRNKVQAEKLWealqkEGMKLDYVIEILLPREVAKNRIMGRRLckndnnHPN-----NIFIDAIKPDGdVCRVCGGEL 158

                         170
                  ....*....|....*....
gi 2052103030 158 VQRDDDKPET-VSKRLQAY 175
Cdd:PRK14529  159 STRADDQDEEaINKRHDIY 177
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 11-192 3.76e-30

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 110.29  E-value: 3.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQlMLNE--LKGLDRYN-WL 87
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLD-LLKDamVAALGTSKgFL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  88 LDGFPRTVAQAEALDKEC-HIDTVIDLDVPFETIKCRLTARwiHPASGRVynlefsppkvqgidditgeplvqrdDDKPE 166
Cdd:TIGR01360  87 IDGYPREVKQGEEFERRIgPPTLVLYFDCSEDTMVKRLLKR--AETSGRV-------------------------DDNEK 139

                         170       180
                  ....*....|....*....|....*.
gi 2052103030 167 TVSKRLQAYDAQTKPVLEYYRKKGLL 192
Cdd:TIGR01360 140 TIKKRLETYYKATEPVIAYYETKGKL 165
PLN02200 PLN02200
adenylate kinase family protein
 11-207 6.50e-27

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 103.05  E-value: 6.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTEVGILAKSYIDQGKLIPDDIMTQLMLNELKGLDRYNWLLDG 90
Cdd:PLN02200   48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNKFLIDG 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  91 FPRTVAQAEALDK--ECHIDTVIDLDVPFETIKCRLTARwihpASGRVynlefsppkvqgidditgeplvqrdDDKPETV 168
Cdd:PLN02200  128 FPRTEENRIAFERiiGAEPNVVLFFDCPEEEMVKRVLNR----NQGRV-------------------------DDNIDTI 178

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2052103030 169 SKRLQAYDAQTKPVLEYYRKKGLLKSFSGTET-NKIWPHI 207
Cdd:PLN02200  179 KKRLKVFNALNLPVIDYYSKKGKLYTINAVGTvDEIFEQV 218
AAA_17 pfam13207
AAA domain;
12-140 1.55e-24

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 94.23  E-value: 1.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  12 MGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKKTevGILAKSYIDQGKLIPDDIMTQLMLNELKGLD-RYNWLLDG 90
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAgEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2052103030  91 FPRTVAQAEALD-------KECHIDTVIDLDVPFETIKCRLTARwihPASGRVY-NLE 140
Cdd:pfam13207  79 HPRIKTPAGYLPglpvevlRELKPDAIILLEADPEEILERRLKD---RTRGRDDdSEE 133
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 127-162 5.43e-17

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 71.72  E-value: 5.43e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2052103030 127 RWIHPASGRVYNLEFSPPKVQGIDDITGEPLVQRDD 162
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 10-48 2.11e-07

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 49.34  E-value: 2.11e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRDNMQKK 48
Cdd:TIGR02173   4 TISGPPGSGKTTVAKILAEKLSLKLISAGDIFRELAAKM 42
PRK04182 PRK04182
cytidylate kinase; Provisional
 7-43 4.78e-07

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 48.26  E-value: 4.78e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2052103030   7 LRAVIMGPPGSGKGTVSARIIKHFGMKHLSSGDLLRD 43
Cdd:PRK04182    1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 11-40 6.58e-07

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 47.48  E-value: 6.58e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDL 40
Cdd:cd02020     4 IDGPAGSGKSTVAKLLAKKLGLPYLDTGGI 33
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 10-130 2.07e-05

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 43.01  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLsSGDLLR--DNMQKKTevgilaksyidQGklIP-DDIMTQLMLNELKGlDRYNW 86
Cdd:cd02021     3 VVMGVSGSGKSTVGKALAERLGAPFI-DGDDLHppANIAKMA-----------AG--IPlNDEDRWPWLQALTD-ALLAK 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2052103030  87 LLDGFPRTVAQAEAL--------DKECHI--DTVIDLDVPFETIKCRLTARWIH 130
Cdd:cd02021    68 LASAGEGVVVACSALkriyrdilRGGAANprVRFVHLDGPREVLAERLAARKGH 121
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-127 2.68e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 42.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIIKHFGMKHLSSgDLLRdnmqkKTevgiLAKSYIDQGKLIPD------DIMTQLMLNELK-Gld 82
Cdd:COG0645     3 LVCGLPGSGKSTLARALAERLGAVRLRS-DVVR-----KR----LFGAGLAPLERSPEatartyARLLALARELLAaG-- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2052103030  83 rYNWLLD-GFPR--TVAQAEALDKECHID-TVIDLDVPFETIKCRLTAR 127
Cdd:COG0645    71 -RSVILDaTFLRraQREAFRALAEEAGAPfVLIWLDAPEEVLRERLEAR 118
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
11-42 7.53e-04

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 40.03  E-value: 7.53e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2052103030  11 IMGPPGSGKGTVSARIIKHFGMKHLSSGDLLR 42
Cdd:PRK11860  447 IDGPTASGKGTVAARVAEALGYHYLDSGALYR 478
AAA_18 pfam13238
AAA domain;
10-127 8.60e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 38.18  E-value: 8.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  10 VIMGPPGSGKGTVSARIikhfgMKHLSSGDLLRDNMQKKtEVGILAKSYIDQGKLIPDDIMTQLmLNELKGLDRY----N 85
Cdd:pfam13238   2 LITGTPGVGKTTLAKEL-----SKRLGFGDNVRDLALEN-GLVLGDDPETRESKRLDEDKLDRL-LDLLEENAALeeggN 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2052103030  86 WLLDGFPrtvAQAEA-LDKECHidtVIDLDVPFETIKCRLTAR 127
Cdd:pfam13238  75 LIIDGHL---AELEPeRAKDLV---GIVLRASPEELLERLEKR 111
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 1-153 1.84e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 37.78  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030   1 MVVPPLLraVIMGPPGSGKGTVSARIIKHFGMK-----HLSSgDLLRDNMQK------------KTEVGILAKSYIDQGK 63
Cdd:COG4088     1 MDSPMLL--ILTGPPGSGKTTFAKALAQRLYAEgiavaLLHS-DDFRRFLVNesfpketyeevvEDVRTTTADNALDNGY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052103030  64 -LIPDDIMTqlmlnelkgldrYNWLLDGFprtvAQAEALDKECHIdtvIDLDVPFETI--KCRLTARWIhPASG--RVYN 138
Cdd:COG4088    78 sVIVDGTFY------------YRSWQRDF----RNLAKHKAPIHI---IYLKAPLETAlrRNRERGEPI-PERViaRMYR 137

                         170
                  ....*....|....*
gi 2052103030 139 lEFSPPKVQGIDDIT 153
Cdd:COG4088   138 -KFDKPGTKDRPDLV 151
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
13-38 3.88e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 37.31  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 2052103030  13 GPPGSGKGTVSARIIKHFGMKHLSSG 38
Cdd:COG0283     7 GPAGSGKSTVAKALAKRLGYHYLDTG 32
DEXXQc_UPF1 cd18039
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ...
 11-30 9.54e-03

DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350797 [Multi-domain]  Cd Length: 234  Bit Score: 36.07  E-value: 9.54e-03
                          10        20
                  ....*....|....*....|
gi 2052103030  11 IMGPPGSGKGTVSARIIKHF 30
Cdd:cd18039    21 IQGPPGTGKTVTSATIVYHL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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