|
Name |
Accession |
Description |
Interval |
E-value |
| MACS_euk |
cd05928 |
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ... |
40-574 |
0e+00 |
|
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.
Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 940.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 40 IPAKFNFANDVVDHWANMEKAGKRPPRPALWWMNGSGEELKWNFRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEW 119
Cdd:cd05928 1 VPEYFNFASDVLDQWADKEKAGKRPPNPALWWVNGKGDEVKWSFRELGSLSRKAANVLSGACGLQRGDRVAVILPRVPEW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 120 WLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLLK 199
Cdd:cd05928 81 WLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCIVTSDELAPEVDSVASECPSLKTKLLVSEKSRDGWLNFKELLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 200 DVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWT 279
Cdd:cd05928 161 EASTEHHCVETGSQEPMAIYFTSGTTGSPKMAEHSHSSLGLGLKVNGRYWLDLTASDIMWNTSDTGWIKSAWSSLFEPWI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 280 LGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIR 359
Cdd:cd05928 241 QGACVFVHHLPRFDPLVILKTLSSYPITTFCGAPTVYRMLVQQDLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGLDIY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPFRPIGIFSGYVDNPKKTEANIR 439
Cdd:cd05928 321 EGYGQTETGLICANFKGMKIKPGSMGKASPPYDVQIIDDNGNVLPPGTEGDIGIRVKPIRPFGLFSGYVDNPEKTAATIR 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 GDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAP 519
Cdd:cd05928 401 GDFYLTGDRGIMDEDGYFWFMGRADDVINSSG-----YRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVLAP 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 520 EFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEW 574
Cdd:cd05928 476 QFLSHDPEQLTKELQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDKEW 530
|
|
| MACS_like |
cd05972 |
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ... |
81-571 |
0e+00 |
|
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.
Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 619.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 81 WNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAG 160
Cdd:cd05972 1 WSFRELKRESAKAANVLAK-LGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEvaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshEPAAIYFTSGTSGLPKMAEHSHSsLGL 240
Cdd:cd05972 80 AE---------------------------------------------------DPALIYFTSGTTGLPKGVLHTHS-YPL 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 241 KAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLL 320
Cdd:cd05972 108 GHIPTAAYWLGLRPDDIHWNIADPGWAKGAWSSFFGPWLLGATVFVYEGPRFDAERILELLERYGVTSFCGPPTAYRMLI 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 321 QQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQG 400
Cdd:cd05972 188 KQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLPIRDGYGQTETGLTVGNFPDMPVKPGSMGRPTPGYDVAIIDDDG 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 401 NVLPPGKEGDIAIRVKpfrPIGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIG 480
Cdd:cd05972 268 RELPPGEEGDIAIKLP---PPGLFLGYVGDPEKTEASIRGDYYLTGDRAYRDEDGYFWFVGRADDIIKSSG-----YRIG 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 481 PSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLshDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTI 560
Cdd:cd05972 340 PFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSGYE--PSEELAEELQGHVKKVLAPYKYPREIEFVEELPKTI 417
|
490
....*....|.
gi 2025697431 561 TGKIERAKLRA 571
Cdd:cd05972 418 SGKIRRVELRD 428
|
|
| Acs |
COG0365 |
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]; |
40-574 |
5.47e-177 |
|
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 511.96 E-value: 5.47e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 40 IPAKFNFANDVVDHWANmekagKRPPRPALWWMNGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEW 119
Cdd:COG0365 4 VGGRLNIAYNCLDRHAE-----GRGDKVALIWEGEDGEERTLTYAELRREVNRFANALRA-LGVKKGDRVAIYLPNIPEA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 120 WLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVA---------QEVDAVAPDCSFLKIKLLV----SDN 186
Cdd:COG0365 78 VIAMLACARIGAVHSPVFPGFGAEALADRIEDAEAKVLITADGGLrggkvidlkEKVDEALEELPSLEHVIVVgrtgADV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 187 RREGWLNFKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISDTGW 266
Cdd:COG0365 158 PMEGDLDWDELLAAASAEFEPEPTDADDPLFILYTSGTTGKPKGVVHTHGGYLVHAATTAKYVLDLKPGDVFWCTADIGW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 267 IV---NILTSflePWTLGACVFVY-LLPKF-DPQTVLKVLSSYPINSLVGAPLIYRMLLQQD---LSRYKFPHLHSCYTG 338
Cdd:COG0365 238 ATghsYIVYG---PLLNGATVVLYeGRPDFpDPGRLWELIEKYGVTVFFTAPTAIRALMKAGdepLKKYDLSSLRLLGSA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 339 GESLLPETLENWKAKTGLYIREFYGQTETG---LTCRisRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRv 415
Cdd:COG0365 315 GEPLNPEVWEWWYEAVGVPIVDGWGQTETGgifISNL--PGLPVKPGSMGKPVPGYDVAVVDEDGNPVPPGEEGELVIK- 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 416 KPFrPiGIFSGYVDNPKKTEANIRGDF---WLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHP 492
Cdd:COG0365 392 GPW-P-GMFRGYWNDPERYRETYFGRFpgwYRTGDGARRDEDGYFWILGRSDDVINVSG-----HRIGTAEIESALVSHP 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 493 AVAETVVISSPDPTRGEVVKAFVVLAPEFlsHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:COG0365 465 AVAEAAVVGVPDEIRGQVVKAFVVLKPGV--EPSDELAKELQAHVREELGPYAYPREIEFVDELPKTRSGKIMRRLLRKI 542
|
..
gi 2025697431 573 EW 574
Cdd:COG0365 543 AE 544
|
|
| MACS_AAE_MA_like |
cd05970 |
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ... |
40-573 |
4.94e-168 |
|
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.
Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 488.16 E-value: 4.94e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 40 IPAKFNFANDVVDHWANMEkagkrPPRPALWWMNGSGEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEW 119
Cdd:cd05970 12 VPENFNFAYDVVDAMAKEY-----PDKLALVWCDDAGEERIFTFAELADYSDKTANFFKAM-GIGKGDTVMLTLKRRYEF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 120 WLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVA--GDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTL 197
Cdd:cd05970 86 WYSLLALHKLGAIAIPATHQLTAKDIVYRIESADIKMIVAiaEDNIPEEIEKAAPECPSKPKLVWVGDPVPEGWIDFRKL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 198 LKDVSNT----HHCVETGSHEPAAIYFTSGTSGLPKMAEHSHS-SLG--LKAKMdadsWTGLNVSDTVWTISDTGWIVNI 270
Cdd:cd05970 166 IKNASPDferpTANSYPCGEDILLVYFSSGTTGMPKMVEHDFTyPLGhiVTAKY----WQNVREGGLHLTVADTGWGKAV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 271 LTSFLEPWTLGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENW 350
Cdd:cd05970 242 WGKIYGQWIAGAAVFVYDYDKFDPKALLEKLSKYGVTTFCAPPTIYRFLIREDLSRYDLSSLRYCTTAGEALNPEVFNTF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 351 KAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPFRPIGIFSGYVDN 430
Cdd:cd05970 322 KEKTGIKLMEGFGQTETTLTIATFPWMEPKPGSMGKPAPGYEIDLIDREGRSCEAGEEGEIVIRTSKGKPVGLFGGYYKD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 431 PKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:cd05970 402 AEKTAEVWHDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSG-----YRIGPFEVESALIQHPAVLECAVTGVPDPIRGQV 476
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 511 VKAFVVLAPEFlsHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:cd05970 477 VKATIVLAKGY--EPSEELKKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVEIRERD 537
|
|
| MenE/FadK |
COG0318 |
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ... |
49-579 |
6.25e-121 |
|
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 364.52 E-value: 6.25e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 49 DVVDHWANmekagKRPPRPALWWMNGSgeelkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIR 128
Cdd:COG0318 3 DLLRRAAA-----RHPDRPALVFGGRR-----LTYAELDARARRLAAALRA-LGVGPGDRVALLLPNSPEFVVAFLAALR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 129 TGLVFMPGTIQMKSTDILYRLQSSKARAIVAgdevaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcv 208
Cdd:COG0318 72 AGAVVVPLNPRLTAEELAYILEDSGARALVT------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 209 etgshepAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVWTIS----DTGWIVNILTsflePWTLGACV 284
Cdd:COG0318 103 -------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAAL-GLTPGDVVLVALplfhVFGLTVGLLA----PLLAGATL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 285 fvYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYG 363
Cdd:COG0318 171 --VLLPRFDPERVLELIERERVTVLFGVPTMLARLLRHpEFARYDLSSLRLVVSGGAPLPPELLERFEERFGVRIVEGYG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 364 QTETGL--TCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGD 441
Cdd:COG0318 249 LTETSPvvTVNPEDPGERRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVR-----GPNVMKGYWNDPEATAEAFRDG 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 442 FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEF 521
Cdd:COG0318 324 WLRTGDLGRLDEDGYLYIVGRKKDMIISGG-----ENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVLRPGA 398
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 522 lSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSGQ 579
Cdd:COG0318 399 -ELDAEELRAFLRERL----ARYKVPRRVEFVDELPRTASGKIDRRALRERYAAGALE 451
|
|
| MACS_like_3 |
cd05971 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
80-571 |
9.29e-115 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 348.27 E-value: 9.29e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVa 159
Cdd:cd05971 6 KVTFKELKTASNRFANVLKE-IGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALV- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 160 gdevaqevdavapdcsflkikllvSDnrregwlnfktllkdvsnthhcvetGSHEPAAIYFTSGTSGLPKMAEHSHSSL- 238
Cdd:cd05971 84 ------------------------TD-------------------------GSDDPALIIYTSGTTGPPKGALHAHRVLl 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 239 ----GLKAKMDADSWTGlnvsDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPL 314
Cdd:cd05971 115 ghlpGVQFPFNLFPRDG----DLYWTPADWAWIGGLLDVLLPSLYFGVPVLAHRMTKFDPKAALDLMSRYGVTTAFLPPT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 315 IYRMLLQQDLSRYKFP-HLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGL-TCRISRTMTVKPGSLGTAVPHYD 392
Cdd:cd05971 191 ALKMMRQQGEQLKHAQvKLRAIATGGESLGEELLGWAREQFGVEVNEFYGQTECNLvIGNCSALFPIKPGSMGKPIPGHR 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 393 VQVIDEQGNVLPPGKEGDIAIRvkpfRPIGI-FSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSG 471
Cdd:cd05971 271 VAIVDDNGTPLPPGEVGEIAVE----LPDPVaFLGYWNNPSATEKKMAGDWLLTGDLGRKDSDGYFWYVGRDDDVITSSG 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 472 tsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLshDPDQLTKLLQQHVKSVTAPYKYPRKVE 551
Cdd:cd05971 347 -----YRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPGET--PSDALAREIQELVKTRLAAHEYPREIE 419
|
490 500
....*....|....*....|
gi 2025697431 552 FVLDLPKTITGKIERAKLRA 571
Cdd:cd05971 420 FVNELPRTATGKIRRRELRA 439
|
|
| MACS_like_1 |
cd05974 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
83-573 |
3.10e-106 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 326.45 E-value: 3.10e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKArAIVAGDE 162
Cdd:cd05974 3 FAEMSARSSRVANFLRS-IGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLRDRVDRGGA-VYAAVDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 VaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcveTGSHEPAAIYFTSGTSGLPKMAEHSHSS--LGL 240
Cdd:cd05974 81 N----------------------------------------------THADDPMLLYFTSGTTSKPKLVEHTHRSypVGH 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 241 KAKMdadSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLL 320
Cdd:cd05974 115 LSTM---YWIGLKPGDVHWNISSPGWAKHAWSCFFAPWNAGATVFLFNYARFDAKRVLAALVRYGVTTLCAPPTVWRMLI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 321 QQDLSRYKFPhLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETglTCRISRT--MTVKPGSLGTAVPHYDVQVIDE 398
Cdd:cd05974 192 QQDLASFDVK-LREVVGAGEPLNPEVIEQVRRAWGLTIRDGYGQTET--TALVGNSpgQPVKAGSMGRPLPGYRVALLDP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 399 QGNvlpPGKEGDIAIRVKPFRPIGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYR 478
Cdd:cd05974 269 DGA---PATEGEVALDLGDTRPVGLMKGYAGDPDKTAHAMRGGYYRTGDIAMRDEDGYLTYVGRADDVFKSSD-----YR 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 479 IGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEflSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVlDLPK 558
Cdd:cd05974 341 ISPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVLRAG--YEPSPETALEIFRFSRERLAPYKRIRRLEFA-ELPK 417
|
490
....*....|....*
gi 2025697431 559 TITGKIERAKLRAKE 573
Cdd:cd05974 418 TISGKIRRVELRRRE 432
|
|
| FC-FACS_FadD_like |
cd05936 |
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ... |
58-570 |
4.98e-104 |
|
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 321.82 E-value: 4.98e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWMngsgeELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:cd05936 7 EAARRFPDKTALIFM-----GRKLTYRELDALAEAFAAGLQN-LGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDEvaqevdavapdcsflkikllvsdnrregwlnFKTLLKDVSNTHHCVETGSHEPAA 217
Cdd:cd05936 81 PLYTPRELEHILNDSGAKALIVAVS-------------------------------FTDLLAAGAPLGERVALTPEDVAV 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPKMAEHSHSSLGLKAKMdADSWTG--LNVSDTVWTI----SDTGWIVNILTSFLepwtLGACvfVYLLPK 291
Cdd:cd05936 130 LQYTSGTTGVPKGAMLTHRNLVANALQ-IKAWLEdlLEGDDVVLAAlplfHVFGLTVALLLPLA----LGAT--IVLIPR 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETG-L 369
Cdd:cd05936 203 FRPIGVLKEIRKHRVTIFPGVPTMYIALLNApEFKKRDFSSLRLCISGGAPLPVEVAERFEELTGVPIVEGYGLTETSpV 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 370 TCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPKKTEANIRgDFWLL-G 446
Cdd:cd05936 283 VAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVR-------GpqVMKGYWNRPEETAEAFV-DGWLRtG 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDP 526
Cdd:cd05936 355 DIGYMDEDGYFFIVDRKKDMIIVGG-----FNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVVLKEG-ASLTE 428
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2025697431 527 DQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05936 429 EEIIAFCREQL----AGYKVPRQVEFRDELPKSAVGKILRRELR 468
|
|
| PRK04319 |
PRK04319 |
acetyl-CoA synthetase; Provisional |
43-573 |
9.50e-103 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 321.84 E-value: 9.50e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 43 KFNFANDVVDHWANMEKAGKrpprPALWWMNGSGEElKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLV 122
Cdd:PRK04319 41 KVNIAYEAIDRHADGGRKDK----VALRYLDASRKE-KYTYKELKELSNKFANVLKE-LGVEKGDRVFIFMPRIPELYFA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 123 TLGCIRTGLV-------FMPGTIQMkstdilyRLQSSKARAIVAGDEVAQEVdaVAPDCSFLKIKLLVSDNRR--EGWLN 193
Cdd:PRK04319 115 LLGALKNGAIvgplfeaFMEEAVRD-------RLEDSEAKVLITTPALLERK--PADDLPSLKHVLLVGEDVEegPGTLD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 194 FKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSlglkakMDADSWTG-----LNVSDTVWTISDTGWIV 268
Cdd:PRK04319 186 FNALMEQASDEFDIEWTDREDGAILHYTSGSTGKPKGVLHVHNA------MLQHYQTGkyvldLHEDDVYWCTADPGWVT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 269 NilTSF--LEPWTLGACVFVYLlPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQD---LSRYKFPHLHSCYTGGESLL 343
Cdd:PRK04319 260 G--TSYgiFAPWLNGATNVIDG-GRFSPERWYRILEDYKVTVWYTAPTAIRMLMGAGddlVKKYDLSSLRHILSVGEPLN 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 344 PETLEnWKAKT-GLYIREFYGQTETG--LTCRIsRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIrvKPFRP 420
Cdd:PRK04319 337 PEVVR-WGMKVfGLPIHDNWWMTETGgiMIANY-PAMDIKPGSMGKPLPGIEAAIVDDQGNELPPNRMGNLAI--KKGWP 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 421 iGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVI 500
Cdd:PRK04319 413 -SMMRGIWNNPEKYESYFAGDWYVSGDSAYMDEDGYFWFQGRVDDVIKTSG-----ERVGPFEVESKLMEHPAVAEAGVI 486
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 501 SSPDPTRGEVVKAFVVLAPeflSHDP-DQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK04319 487 GKPDPVRGEIIKAFVALRP---GYEPsEELKEEIRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRRVLKAWE 557
|
|
| MACS_like_4 |
cd05969 |
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ... |
81-573 |
5.17e-96 |
|
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.
Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 300.19 E-value: 5.17e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 81 WNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAG 160
Cdd:cd05969 1 YTFAQLKVLSARFANVLKS-LGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLITT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEVAQevdavapdcsflkikllvsdnrregwlnfKTLLKDvsnthhcvetgshePAAIYFTSGTSGLPKMAEHSHSSlgl 240
Cdd:cd05969 80 EELYE-----------------------------RTDPED--------------PTLLHYTSGTTGTPKGVLHVHDA--- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 241 kakMDADSWTG-----LNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLlPKFDPQTVLKVLSSYPINSLVGAPLI 315
Cdd:cd05969 114 ---MIFYYFTGkyvldLHPDDIYWCTADPGWVTGTVYGIWAPWLNGVTNVVYE-GRFDAESWYGIIERVKVTVWYTAPTA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 316 YRMLLQQD---LSRYKFPHLHSCYTGGESLLPETLEnWKAKT-GLYIREFYGQTETGlTCRISR--TMTVKPGSLGTAVP 389
Cdd:cd05969 190 IRMLMKEGdelARKYDLSSLRFIHSVGEPLNPEAIR-WGMEVfGVPIHDTWWQTETG-SIMIANypCMPIKPGSMGKPLP 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 390 HYDVQVIDEQGNVLPPGKEGDIAIrvKPFRPiGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINS 469
Cdd:cd05969 268 GVKAAVVDENGNELPPGTKGILAL--KPGWP-SMFRGIWNDEERYKNSFIDGWYLTGDLAYRDEDGYFWFVGRADDIIKT 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 470 SGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlshDP-DQLTKLLQQHVKSVTAPYKYPR 548
Cdd:cd05969 345 SG-----HRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISLKEGF---EPsDELKEEIINFVRQKLGAHVAPR 416
|
490 500
....*....|....*....|....*
gi 2025697431 549 KVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:cd05969 417 EIEFVDNLPKTRSGKIMRRVLKAKE 441
|
|
| AFD_class_I |
cd04433 |
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ... |
214-564 |
1.78e-94 |
|
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 292.65 E-value: 1.78e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLgLKAKMDADSWTGLNVSDTVWTISDTGWIvNILTSFLEPWTLGACVfvYLLPKFD 293
Cdd:cd04433 1 DPALILYTSGTTGKPKGVVLSHRNL-LAAAAALAASGGLTEGDVFLSTLPLFHI-GGLFGLLGALLAGGTV--VLLPKFD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 294 PQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSR-YKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCR 372
Cdd:cd04433 77 PEAALELIEREKVTILLGVPTLLARLLKAPESAgYDLSSLRALVSGGAPLPPELLERFEEAPGIKLVNGYGLTETGGTVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 373 ISR--TMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGDFWLLGDRGT 450
Cdd:cd04433 157 TGPpdDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVR-----GPSVMKGYWNNPEATAAVDEDGWYRTGDLGR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 451 KDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlSHDPDQlt 530
Cdd:cd04433 232 LDEDGYLYIVGRLKDMIKSGG-----ENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGA-DLDAEE-- 303
|
330 340 350
....*....|....*....|....*....|....
gi 2025697431 531 klLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKI 564
Cdd:cd04433 304 --LRAHVRERLAPYKVPRRVVFVDALPRTASGKI 335
|
|
| MACS_like_2 |
cd05973 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
83-570 |
4.03e-90 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 284.80 E-value: 4.03e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVagde 162
Cdd:cd05973 3 FGELRALSARFANALQE-LGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARLVV---- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 vaqeVDAvapdcsflkikllvsDNRregwlnfktllkdvsnthHCVETGshePAAIYFTSGTSGLPKMAEHSHSSL-GLK 241
Cdd:cd05973 78 ----TDA---------------ANR------------------HKLDSD---PFVMMFTSGTTGLPKGVPVPLRALaAFG 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 242 AKM-DAdswTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLLPkFDPQTVLKVLSSYPINSLVGAPLIYRMLL 320
Cdd:cd05973 118 AYLrDA---VDLRPEDSFWNAADPGWAYGLYYAITGPLALGHPTILLEGG-FSVESTWRVIERLGVTNLAGSPTAYRLLM 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 321 QQDLSRYKFP--HLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMT--VKPGSLGTAVPHYDVQVI 396
Cdd:cd05973 194 AAGAEVPARPkgRLRRVSSAGEPLTPEVIRWFDAALGVPIHDHYGQTELGMVLANHHALEhpVHAGSAGRAMPGWRVAVL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 397 DEQGNVLPPGKEGDIAIRVKPfRPIGIFSGYVDNPKKTeanIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcr 476
Cdd:cd05973 274 DDDGDELGPGEPGRLAIDIAN-SPLMWFRGYQLPDTPA---IDGGYYLTGDTVEFDPDGSFSFIGRADDVITMSG----- 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 477 YRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPeflSHDP-DQLTKLLQQHVKSVTAPYKYPRKVEFVLD 555
Cdd:cd05973 345 YRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVLRG---GHEGtPALADELQLHVKKRLSAHAYPRTIHFVDE 421
|
490
....*....|....*
gi 2025697431 556 LPKTITGKIERAKLR 570
Cdd:cd05973 422 LPKTPSGKIQRFLLR 436
|
|
| BCL_4HBCL |
cd05959 |
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ... |
42-570 |
2.74e-88 |
|
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.
Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 282.34 E-value: 2.74e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 42 AKFNFANDVVDHwanmeKAGKRPPRPALWWMNGSgeelkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWL 121
Cdd:cd05959 1 EKYNAATLVDLN-----LNEGRGDKTAFIDDAGS-----LTYAELEAEARRVAGALRA-LGVKREERVLLIMLDTVDFPT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 122 VTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRRE--GWLNFKTLLK 199
Cdd:cd05959 70 AFLGAIRAGIVPVPVNTLLTPDDYAYYLEDSRARVVVVSGELAPVLAAALTKSEHTLVVLIVSGGAGPeaGALLLAELVA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 200 DVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWT 279
Cdd:cd05959 150 AEAEQLKPAATHADDPAFWLYSSGSTGRPKGVVHLHADIYWTAELYARNVLGIREDDVCFSAAKLFFAYGLGNSLTFPLS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 280 LGACVFvyLLPKF-DPQTVLKVLSSYPINSLVGAPLIYR-MLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLY 357
Cdd:cd05959 230 VGATTV--LMPERpTPAAVFKRIRRYRPTVFFGVPTLYAaMLAAPNLPSRDLSSLRLCVSAGEALPAEVGERWKARFGLD 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 358 IREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPFRPigifsGYVDNPKKTEAN 437
Cdd:cd05959 308 ILDGIGSTEMLHIFLSNRPGRVRYGTTGKPVPGYEVELRDEDGGDVADGEPGELYVRGPSSAT-----MYWNNRDKTRDT 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVL 517
Cdd:cd05959 383 FQGEWTRTGDKYVRDDDGFYTYAGRADDMLKVSGI-----WVSPFEVESALVQHPAVLEAAVVGVEDEDGLTKPKAFVVL 457
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 518 APEFlsHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05959 458 RPGY--EDSEALEEELKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
|
|
| PRK06187 |
PRK06187 |
long-chain-fatty-acid--CoA ligase; Validated |
60-575 |
6.22e-87 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 278.99 E-value: 6.22e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK06187 16 ARKHPDKEAVYF-----DGRRTTYAELDERVNRLANALRA-LGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVLHPINIR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREG----WLNFKTLLKDVSNTHHCVETGSHEP 215
Cdd:PRK06187 90 LKPEEIAYILNDAEDRVVLVDSEFVPLLAAILPQLPTVRTVIVEGDGPAAPlapeVGEYEELLAAASDTFDFPDIDENDA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLGLKAkMDADSWTGlnvsdtvWTISDTGWI------VNILTSFLEPWTLGAcvfVYLL 289
Cdd:PRK06187 170 AAMLYTSGTTGHPKGVVLSHRNLFLHS-LAVCAWLK-------LSRDDVYLVivpmfhVHAWGLPYLALMAGA---KQVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PK-FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSR-YKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTET 367
Cdd:PRK06187 239 PRrFDPENLLDLIETERVTFFFAVPTIWQMLLKAPRAYfVDFSSLRLVIYGGAALPPALLREFKEKFGIDLVQGYGMTET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 G--LTC-RISRTMT---VKPGSLGTAVPHYDVQVIDEQGNVLPP-GKE-GDIAIRvkpfrpiG--IFSGYVDNPKKTEAN 437
Cdd:PRK06187 319 SpvVSVlPPEDQLPgqwTKRRSAGRPLPGVEARIVDDDGDELPPdGGEvGEIIVR-------GpwLMQGYWNRPEATAET 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDfWLL-GDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVV 516
Cdd:PRK06187 392 IDGG-WLHtGDVGYIDEDGYLYITDRIKDVIISGGEN-----IYPRELEDALYGHPAVAEVAVIGVPDEKWGERPVAVVV 465
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 517 LAPEFlSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWK 575
Cdd:PRK06187 466 LKPGA-TLDAKELRAFLRGRL----AKFKLPKRIAFVDELPRTSVGKILKRVLREQYAE 519
|
|
| PRK07656 |
PRK07656 |
long-chain-fatty-acid--CoA ligase; Validated |
57-572 |
1.82e-80 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 261.76 E-value: 1.82e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 57 MEKAGKRPPRPALWWMngsgeELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPG 136
Cdd:PRK07656 12 ARAARRFGDKEAYVFG-----DQRLTYAELNARVRRAAAALAA-LGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVVPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTDILYRLQSSKARAIVAGDEVaQEVDAVAPDcSFLKIKLLV------SDNRREGWLNFKTLLKDVSNTHHCVET 210
Cdd:PRK07656 86 NTRYTADEAAYILARGDAKALFVLGLF-LGVDYSATT-RLPALEHVViceteeDDPHTEKMKTFTDFLAAGDPAERAPEV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 211 GSHEPAAIYFTSGTSGLPKMAEHSHSSLgLKAkmdADSW---TGLNVSDTVWTISDT----GWIVNILTSFLEpwtlGAC 283
Cdd:PRK07656 164 DPDDVADILFTSGTTGRPKGAMLTHRQL-LSN---AADWaeyLGLTEGDRYLAANPFfhvfGYKAGVNAPLMR----GAT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 284 VFVylLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLY-IREF 361
Cdd:PRK07656 236 ILP--LPVFDPDEVFRLIETERITVLPGPPTMYNSLLQHpDRSAEDLSSLRLAVTGAASMPVALLERFESELGVDiVLTG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTE-TGLT--CRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPKKTEA 436
Cdd:PRK07656 314 YGLSEaSGVTtfNRLDDDRKTVAGTIGTAIAGVENKIVNELGEEVPVGEVGELLVR-------GpnVMKGYYDDPEATAA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 437 NIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFV 515
Cdd:PRK07656 387 AIDADGWLhTGDLGRLDEEGYLYIVDRKKDMFIVGG-----FNVYPAEVEEVLYEHPAVAEAAVIGVPDERLGEVGKAYV 461
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 516 VLAPEflshdpDQLT-KLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PRK07656 462 VLKPG------AELTeEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALREK 513
|
|
| ABCL |
cd05958 |
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ... |
78-570 |
3.37e-79 |
|
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.
Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 256.25 E-value: 3.37e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWNFRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSK-ARA 156
Cdd:cd05958 8 EREWTYRDLLALANRIANVLVGELGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYILDKARiTVA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 157 IVAGDEVAQEvdavapdcsflkikllvsdnrregwlnfktllkDVsnthhcvetgshepAAIYFTSGTSGLPKMAEHSHS 236
Cdd:cd05958 88 LCAHALTASD---------------------------------DI--------------CILAFTSGTTGAPKATMHFHR 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 237 SLGLKAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFvyLLPKFDPQTVLKVLSSYPINSLVGAPLIY 316
Cdd:cd05958 121 DPLASADRYAVNVLRLREDDRFVGSPPLAFTFGLGGVLLFPFGVGASGV--LLEEATPDLLLSAIARYKPTVLFTAPTAY 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 317 RMLL------QQDLSrykfpHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETgLTCRIS-RTMTVKPGSLGTAVP 389
Cdd:cd05958 199 RAMLahpdaaGPDLS-----SLRKCVSAGEALPAALHRAWKEATGIPIIDGIGSTEM-FHIFISaRPGDARPGATGKPVP 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 390 HYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpigifSGYVDNPKKTEANIRGDFWLL-GDRGTKDPEGYFHFIGRTDDIIN 468
Cdd:cd05958 273 GYEAKVVDDEGNPVPDGTIGRLAVRGP--------TGCRYLADKRQRTYVQGGWNItGDTYSRDPDGYFRHQGRSDDMIV 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 469 SSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEflsHDPD-QLTKLLQQHVKSVTAPYKYP 547
Cdd:cd05958 345 SGG-----YNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRPG---VIPGpVLARELQDHAKAHIAPYKYP 416
|
490 500
....*....|....*....|...
gi 2025697431 548 RKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05958 417 RAIEFVTELPRTATGKLQRFALR 439
|
|
| FACL_FadD13-like |
cd17631 |
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ... |
60-564 |
4.80e-77 |
|
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.
Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 250.61 E-value: 4.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWMNGSgeelkWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:cd17631 5 ARRHPDRTALVFGGRS-----LTYAELDERVNRLAHALRAL-GVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVagdevaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcvetgsHEPAAIY 219
Cdd:cd17631 79 LTPPEVAYILADSGAKVLF------------------------------------------------------DDLALLM 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 220 FTSGTSGLPKMAEHSHSSL---GLKAKMDADSWTGlNVSDTVWTISDTGWIvNILTSFlepwTLGACVFVYLLPKFDPQT 296
Cdd:cd17631 105 YTSGTTGRPKGAMLTHRNLlwnAVNALAALDLGPD-DVLLVVAPLFHIGGL-GVFTLP----TLLRGGTVVILRKFDPET 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 297 VLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKtGLYIREFYGQTETG-LTCRIS 374
Cdd:cd17631 179 VLDLIERHRVTSFFLVPTMIQALLQHpRFATTDLSSLRAVIYGGAPMPERLLRALQAR-GVKFVQGYGMTETSpGVTFLS 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 375 RTMTV-KPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDfWLL-GDRGTKD 452
Cdd:cd17631 258 PEDHRrKLGSAGRPVFFVEVRIVDPDGREVPPGEVGEIVVR-GP----HVMAGYWNRPEATAAAFRDG-WFHtGDLGRLD 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 453 PEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQLTKl 532
Cdd:cd17631 332 EDGYLYIVDRKKDMIISGGEN-----VYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVVPRPG-AELDEDELIA- 404
|
490 500 510
....*....|....*....|....*....|..
gi 2025697431 533 lqqHVKSVTAPYKYPRKVEFVLDLPKTITGKI 564
Cdd:cd17631 405 ---HCRERLARYKIPKSVEFVDALPRNATGKI 433
|
|
| BCL_like |
cd05919 |
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ... |
83-570 |
4.08e-75 |
|
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.
Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 245.45 E-value: 4.08e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDe 162
Cdd:cd05919 13 YGQLHDGANRLGSALRN-LGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDCEARLVVTSA- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 vaqevDAVApdcsflkikllvsdnrreGWLnfktllkdvsnthhcvetgshepaaiyFTSGTSGLPKMAEHSHSSLGLKA 242
Cdd:cd05919 91 -----DDIA------------------YLL---------------------------YSSGTTGPPKGVMHAHRDPLLFA 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 243 KMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLLPKfDPQTVLKVLSSYPINSLVGAPLIY-RMLLQ 321
Cdd:cd05919 121 DAMAREALGLTPGDRVFSSAKMFFGYGLGNSLWFPLAVGASAVLNPGWP-TAERVLATLARFRPTVLYGVPTFYaNLLDS 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 322 QDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGN 401
Cdd:cd05919 200 CAGSPDALRSLRLCVSAGEALPRGLGERWMEHFGGPILDGIGATEVGHIFLSNRPGAWRLGSTGRPVPGYEIRLVDEEGH 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 402 VLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcRYrIGP 481
Cdd:cd05919 280 TIPPGEEGDLLVRGP-----SAAVGYWNNPEKSRATFNGGWYRTGDKFCRDADGWYTHAGRADDMLKVGG----QW-VSP 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 482 SEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlshDPDQ-LTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTI 560
Cdd:cd05919 350 VEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPA---APQEsLARDIHRHLLERLSAHKVPRRIAFVDELPRTA 426
|
490
....*....|
gi 2025697431 561 TGKIERAKLR 570
Cdd:cd05919 427 TGKLQRFKLR 436
|
|
| AMP-binding |
pfam00501 |
AMP-binding enzyme; |
58-470 |
1.45e-70 |
|
AMP-binding enzyme;
Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 232.97 E-value: 1.45e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALwwmnGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:pfam00501 3 RQAARTPDKTAL----EVGEGRRLTYRELDERANRLAAGLRA-LGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDE-VAQEVDAVAPDCSFLKIKLLVS-DNRREGWLNFKTLLKDVSNTHHCVETGSHEP 215
Cdd:pfam00501 78 PRLPAEELAYILEDSGAKVLITDDAlKLEELLEALGKLEVVKLVLVLDrDPVLKEEPLPEEAKPADVPPPPPPPPDPDDL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSL---GLKAKMDADSWTGLNVSDTVWTIS----DTGWIVNILTSFLepwtLGACVfvYL 288
Cdd:pfam00501 158 AYIIYTSGTTGKPKGVMLTHRNLvanVLSIKRVRPRGFGLGPDDRVLSTLplfhDFGLSLGLLGPLL----AGATV--VL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 289 LPKF---DPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQ 364
Cdd:pfam00501 232 PPGFpalDPAALLELIERYKVTVLYGVPTLLNMLLEAgAPKRALLSSLRLVLSGGAPLPPELARRFRELFGGALVNGYGL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 365 TETGLTCRISRTM---TVKPGSLGTAVPHYDVQVIDEQ-GNVLPPGKEGDIAIRvkpfRPiGIFSGYVDNPKKTEANIRG 440
Cdd:pfam00501 312 TETTGVVTTPLPLdedLRSLGSVGRPLPGTEVKIVDDEtGEPVPPGEPGELCVR----GP-GVMKGYLNDPELTAEAFDE 386
|
410 420 430
....*....|....*....|....*....|.
gi 2025697431 441 DFWLL-GDRGTKDPEGYFHFIGRTDDIINSS 470
Cdd:pfam00501 387 DGWYRtGDLGRRDEDGYLEIVGRKKDQIKLG 417
|
|
| PRK08316 |
PRK08316 |
acyl-CoA synthetase; Validated |
60-570 |
4.22e-70 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 234.83 E-value: 4.22e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK08316 21 ARRYPDKTALVF-----GDRSWTYAELDAAVNRVAAALLD-LGLKKGDRVAALGHNSDAYALLWLACARAGAVHVPVNFM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRRE---GWLNFKTLLKDVSNTHHCVETGSHEPA 216
Cdd:PRK08316 95 LTGEELAYILDHSGARAFLVDPALAPTAEAALALLPVDTLILSLVLGGREapgGWLDFADWAEAGSVAEPDVELADDDLA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 217 AIYFTSGTSGLPKMAEHSHSSLglkakmdadswtglnVSDTVWTISDTGW-----IVNILT--------SFLEPWT-LGA 282
Cdd:PRK08316 175 QILYTSGTESLPKGAMLTHRAL---------------IAEYVSCIVAGDMsaddiPLHALPlyhcaqldVFLGPYLyVGA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVFvyLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGeSLLP-ETLENWKAK-TGLYIR 359
Cdd:PRK08316 240 TNV--ILDAPDPELILRTIEAERITSFFAPPTVWISLLRHpDFDTRDLSSLRKGYYGA-SIMPvEVLKELRERlPGLRFY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTEtgltcrISRTMTV--------KPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAirvkpFRPIGIFSGYVDNP 431
Cdd:PRK08316 317 NCYGQTE------IAPLATVlgpeehlrRPGSAGRPVLNVETRVVDDDGNDVAPGEVGEIV-----HRSPQLMLGYWDDP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 432 KKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVV 511
Cdd:PRK08316 386 EKTAEAFRGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGEN-----VASREVEEALYTHPAVAEVAVIGLPDPKWIEAV 460
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 512 KAFVVLAPEfLSHDPDQLTKllqqHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK08316 461 TAVVVPKAG-ATVTEDELIA----HCRARLAGFKVPKRVIFVDELPRNPSGKILKRELR 514
|
|
| FACL_DitJ_like |
cd05934 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
78-570 |
1.31e-68 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.
Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 227.94 E-value: 1.31e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiqmksTDILYRlqsskarai 157
Cdd:cd05934 1 GRRWTYAELLRESARIAAALAA-LGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVP-------INTALR--------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 vaGDEVAQEVDAVAPdcsflkiKLLVSDnrregwlnfktllkdvsnthhcvetgshePAAIYFTSGTSGLPKMAEHSHSS 237
Cdd:cd05934 64 --GDELAYIIDHSGA-------QLVVVD-----------------------------PASILYTSGTTGPPKGVVITHAN 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 238 LGLKAKMDADsWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGA-CVfvyLLPKFDPQTVLKVLSSY--PINSLVGAPL 314
Cdd:cd05934 106 LTFAGYYSAR-RFGLGEDDVYLTVLPLFHINAQAVSVLAALSVGAtLV---LLPRFSASRFWSDVRRYgaTVTNYLGAML 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 315 iyRMLLQQDLSRYKFPH-LHSCYTGGesLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDV 393
Cdd:cd05934 182 --SYLLAQPPSPDDRAHrLRAAYGAP--NPPELHEEFEERFGVRLLEGYGMTETIVGVIGPRDEPRRPGSIGRPAPGYEV 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 394 QVIDEQGNVLPPGKEGDIAIRvkPFRPIGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTS 473
Cdd:cd05934 258 RIVDDDGQELPAGEPGELVIR--GLRGWGFFKGYYNMPEATAEAMRNGWFHTGDLGYRDADGFFYFVDRKKDMIRRRGEN 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 474 fcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVL-APEFLshDPDQLTKLLQQHVksvtAPYKYPRKVEF 552
Cdd:cd05934 336 -----ISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLrPGETL--DPEELFAFCEGQL----AYFKVPRYIRF 404
|
490
....*....|....*...
gi 2025697431 553 VLDLPKTITGKIERAKLR 570
Cdd:cd05934 405 VDDLPKTPTEKVAKAQLR 422
|
|
| ACS-like |
cd17634 |
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ... |
42-564 |
9.40e-68 |
|
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 230.16 E-value: 9.40e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 42 AKFNFANDVVD-HWANmekagkRPPRPALWWMNGSGEELK-WNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEW 119
Cdd:cd17634 50 ATLNLAANALDrHLRE------NGDRTAIIYEGDDTSQSRtISYRELHREVCRFAGTLLD-LGVKKGDRVAIYMPMIPEA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 120 WLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDE----------VAQEVDAVAPDCSFLKIKLLVsdnRRE 189
Cdd:cd17634 123 AVAMLACARIGAVHSVIFGGFAPEAVAGRIIDSSSRLLITADGgvragrsvplKKNVDDALNPNVTSVEHVIVL---KRT 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 190 G---------WLNFKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVWT 260
Cdd:cd17634 200 GsdidwqegrDLWWRDLIAKASPEHQPEAMNAEDPLFILYTSGTTGKPKGVLHTTGGYLVYAATTMKYVFDYGPGDIYWC 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 261 ISDTGWIVNILTSFLEPWTLGACVFVYL-LPKF-DPQTVLKVLSSYPINSLVGAPLIYRMLLQQD---LSRYKFPHLHSC 335
Cdd:cd17634 280 TADVGWVTGHSYLLYGPLACGATTLLYEgVPNWpTPARMWQVVDKHGVNILYTAPTAIRALMAAGddaIEGTDRSSLRIL 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 336 YTGGESLLPETLE-NWK--AKTGLYIREFYGQTETGLTCRISR--TMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGD 410
Cdd:cd17634 360 GSVGEPINPEAYEwYWKkiGKEKCPVVDTWWQTETGGFMITPLpgAIELKAGSATRPVFGVQPAVVDNEGHPQPGGTEGN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 411 IAIRVkPFrPIGIFSGYVDNPKKTEANIR--GDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENAL 488
Cdd:cd17634 440 LVITD-PW-PGQTRTLFGDHERFEQTYFStfKGMYFSGDGARRDEDGYYWITGRSDDVINVAG-----HRLGTAEIESVL 512
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 489 MEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLshDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKI 564
Cdd:cd17634 513 VAHPKVAEAAVVGIPHAIKGQAPYAYVVLNHGVE--PSPELYAELRNWVRKEIGPLATPDVVHWVDSLPKTRSGKI 586
|
|
| PrpE |
cd05967 |
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ... |
63-571 |
1.02e-67 |
|
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 230.67 E-value: 1.02e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 63 RPPRPALWWMNGS-GEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTG----LVFmpGT 137
Cdd:cd05967 64 RGDQIALIYDSPVtGTERTYTYAELLDEVSRLAGVLRK-LGVVKGDRVIIYMPMIPEAAIAMLACARIGaihsVVF--GG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 iqMKSTDILYRLQSSKARAIVAGD---------------EVAQEVDAVAPDCSFLKIKLLVSD--NRREGWLNFKTLLKD 200
Cdd:cd05967 141 --FAAKELASRIDDAKPKLIVTAScgiepgkvvpykpllDKALELSGHKPHHVLVLNRPQVPAdlTKPGRDLDWSELLAK 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 201 VSnTHHCVETGSHEPAAIYFTSGTSGLPK--MAEHSHSSLGLKAKMDadSWTGLNVSDTVWTISDTGWIVNILTSFLEPW 278
Cdd:cd05967 219 AE-PVDCVPVAATDPLYILYTSGTTGKPKgvVRDNGGHAVALNWSMR--NIYGIKPGDVWWAASDVGWVVGHSYIVYGPL 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 279 TLGACVFVY-----LLPkfDPQTVLKVLSSYPINSLVGAPLIYRMLLQQD-----LSRYKFPHLHSCYTGGESLLPETLE 348
Cdd:cd05967 296 LHGATTVLYegkpvGTP--DPGAFWRVIEKYQVNALFTAPTAIRAIRKEDpdgkyIKKYDLSSLRTLFLAGERLDPPTLE 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 349 NWKAKTGLYIREFYGQTETG----LTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVkPFRPiGIF 424
Cdd:cd05967 374 WAENTLGVPVIDHWWQTETGwpitANPVGLEPLPIKAGSPGKPVPGYQVQVLDEDGEPVGPNELGNIVIKL-PLPP-GCL 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 425 SGYVDNPKKTEANIRGDF---WLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVIS 501
Cdd:cd05967 452 LTLWKNDERFKKLYLSKFpgyYDTGDAGYKDEDGYLFIMGRTDDVINVAG-----HRLSTGEMEESVLSHPAVAECAVVG 526
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 502 SPDPTRGEVVKAFVVLAPEfLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05967 527 VRDELKGQVPLGLVVLKEG-VKITAEELEKELVALVREQIGPVAAFRLVIFVKRLPKTRSGKILRRTLRK 595
|
|
| benz_CoA_lig |
TIGR02262 |
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ... |
43-570 |
1.62e-67 |
|
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.
Pssm-ID: 274059 [Multi-domain] Cd Length: 505 Bit Score: 227.41 E-value: 1.62e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 43 KFNFANDVVDHwaNMEkagkRPPRPALWWMNGSGeelKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLV 122
Cdd:TIGR02262 2 KYNAAEDLLDR--NVV----EGRGGKTAFIDDIS---SLSYGELEAQVRRLAAALRR-LGVKREERVLLLMLDGVDFPIA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 123 TLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKiKLLVSDNRREGWLNFKTLLKDVS 202
Cdd:TIGR02262 72 FLGAIRAGIVPVALNTLLTADDYAYMLEDSRARVVFVSGALLPVIKAALGKSPHLE-HRVVVGRPEAGEVQLAELLATES 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 203 NTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGA 282
Cdd:TIGR02262 151 EQFKPAATQADDPAFWLYSSGSTGMPKGVVHTHSNPYWTAELYARNTLGIREDDVCFSAAKLFFAYGLGNALTFPMSVGA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVFVYLlPKFDPQTVLKVLSSYPINSLVGAPLIYR-MLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREF 361
Cdd:TIGR02262 231 TTVLMG-ERPTPDAVFDRLRRHQPTIFYGVPTLYAaMLADPNLPSEDQVRLRLCTSAGEALPAEVGQRWQARFGVDIVDG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiGIFS--GYVDNPKKTEANIR 439
Cdd:TIGR02262 310 IGSTEMLHIFLSNLPGDVRYGTSGKPVPGYRLRLVGDGGQDVADGEPGELLIS-------GPSSatMYWNNRAKSRDTFQ 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 GDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAP 519
Cdd:TIGR02262 383 GEWTRSGDKYVRNDDGSYTYAGRTDDMLKVSGI-----YVSPFEIESALIQHPAVLEAAVVGVADEDGLIKPKAFVVLRP 457
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 520 EFlshdpDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:TIGR02262 458 GQ-----TALETELKEHVKDRLAPYKYPRWIVFVDDLPKTATGKIQRFKLR 503
|
|
| MCS |
cd05941 |
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ... |
83-571 |
2.69e-67 |
|
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 225.25 E-value: 2.69e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVagde 162
Cdd:cd05941 14 YADLVARAARLANRLLALGKDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVITDSEPSLVL---- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 vaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshEPAAIYFTSGTSGLPKMAEHSHSSLGLKA 242
Cdd:cd05941 90 ---------------------------------------------------DPALILYTSGTTGRPKGVVLTHANLAANV 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 243 KMDADSWTglnvsdtvWTISD----------TGWIVNILTSFLepWTLGACVFvylLPKFDPQTVLKVLSSYPINSLVGA 312
Cdd:cd05941 119 RALVDAWR--------WTEDDvllhvlplhhVHGLVNALLCPL--FAGASVEF---LPKFDPKEVAISRLMPSITVFMGV 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 313 PLIYRMLLQ---------QDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETG--LTCRI--SRtmtv 379
Cdd:cd05941 186 PTIYTRLLQyyeahftdpQFARAAAAERLRLMVSGSAALPVPTLEEWEAITGHTLLERYGMTEIGmaLSNPLdgER---- 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 380 KPGSLGTAVPHYDVQVIDEQGN-VLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYF 457
Cdd:cd05941 262 RPGTVGMPLPGVQARIVDEETGePLPRGEVGEIQVR-GP----SVFKEYWNKPEATKEEFTDDGWFkTGDLGVVDEDGYY 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 458 HFIGRT-DDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDPDQLTKLLQQH 536
Cdd:cd05941 337 WILGRSsVDIIKSGG-----YKVSALEIERVLLAHPGVSECAVIGVPDPDWGERVVAVVVLRAGAAALSLEELKEWAKQR 411
|
490 500 510
....*....|....*....|....*....|....*
gi 2025697431 537 VksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05941 412 L----APYKRPRRLILVDELPRNAMGKVNKKELRK 442
|
|
| Firefly_Luc_like |
cd05911 |
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ... |
80-564 |
2.10e-66 |
|
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 224.01 E-value: 2.10e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAI-V 158
Cdd:cd05911 10 ELTYAQLRTLSRRLAAGLRK-LGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPKVIfT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 159 AGDEVAQEVDAVApdCSFLKIKLLVSDNRREGWLNFKTLLKDVSNTHH-----CVETGSHEPAAIYFTSGTSGLPKMAEH 233
Cdd:cd05911 89 DPDGLEKVKEAAK--ELGPKDKIIVLDDKPDGVLSIEDLLSPTLGEEDedlppPLKDGKDDTAAILYSSGTTGLPKGVCL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 234 SHSSLGLKAKMDADSWTGLNVSDTVW-TISDTGWIVNILTSFLEPWtLGACVfvYLLPKFDPQTVLKVLSSYPINSLVGA 312
Cdd:cd05911 167 SHRNLIANLSQVQTFLYGNDGSNDVIlGFLPLYHIYGLFTTLASLL-NGATV--IIMPKFDSELFLDLIEKYKITFLYLV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 313 PLIYRMLLQQ-DLSRYKFPHLHSCYTGG-------ESLLPETLENWKAKTGlyirefYGQTETGLTCRISRTMTVKPGSL 384
Cdd:cd05911 244 PPIAAALAKSpLLDKYDLSSLRVILSGGaplskelQELLAKRFPNATIKQG------YGMTETGGILTVNPDGDDKPGSV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 385 GTAVPHYDVQVIDEQGN-VLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGR 462
Cdd:cd05911 318 GRLLPNVEAKIVDDDGKdSLGPNEPGEICVR-----GPQVMKGYYNNPEATKETFDEDGWLhTGDIGYFDEDGYLYIVDR 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 463 TDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLShDPDQLTKLLQQHVksvtA 542
Cdd:cd05911 393 KKELIKYKG-----FQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPGEKL-TEKEVKDYVAKKV----A 462
|
490 500
....*....|....*....|...
gi 2025697431 543 PYKYPRK-VEFVLDLPKTITGKI 564
Cdd:cd05911 463 SYKQLRGgVVFVDEIPKSASGKI 485
|
|
| PRK08314 |
PRK08314 |
long-chain-fatty-acid--CoA ligase; Validated |
54-574 |
1.11e-64 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 220.99 E-value: 1.11e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 54 WANMEKAGKR-PPRPALWWMngsGEELKwnFRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLV 132
Cdd:PRK08314 13 FHNLEVSARRyPDKTAIVFY---GRAIS--YRELLEEAERLAGYLQQECGVRKGDRVLLYMQNSPQFVIAYYAILRANAV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 133 FMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEV------------------DAVAPDC-----SFLKIKLLVSDNRRE 189
Cdd:PRK08314 88 VVPVNPMNREEELAHYVTDSGARVAIVGSELAPKVapavgnlrlrhvivaqysDYLPAEPeiavpAWLRAEPPLQALAPG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 190 GWlnfkTLLKDVSNTHHC---VETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADsWTGLNVSDTVWTISDTGW 266
Cdd:PRK08314 168 GV----VAWKEALAAGLApppHTAGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVL-WSNSTPESVVLAVLPLFH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 267 IVNILTSFLEPWTLGACVfvYLLPKFDPQTVLKVLSSYPINSLVGAP-LIYRMLLQQDLSRYKFPHLhSCYTGGESLLPE 345
Cdd:PRK08314 243 VTGMVHSMNAPIYAGATV--VLMPRWDREAAARLIERYRVTHWTNIPtMVVDFLASPGLAERDLSSL-RYIGGGGAAMPE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 346 TL-ENWKAKTGLYIREFYGQTETgltcrISRTMT-----VKPGSLGtaVPHYDV--QVID-EQGNVLPPGKEGDIAIRvk 416
Cdd:PRK08314 320 AVaERLKELTGLDYVEGYGLTET-----MAQTHSnppdrPKLQCLG--IPTFGVdaRVIDpETLEELPPGEVGEIVVH-- 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 417 pfrpiG--IFSGYVDNPKKTEA---NIRGD-FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALME 490
Cdd:PRK08314 391 -----GpqVFKGYWNRPEATAEafiEIDGKrFFRTGDLGRMDEEGYFFITDRLKRMINASG-----FKVWPAEVENLLYK 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 491 HPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSH-DPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK08314 461 HPAIQEACVIATPDPRRGETVKAVVVLRPEARGKtTEEEIIAWAREHM----AAYKYPRIVEFVDSLPKSGSGKILWRQL 536
|
....*
gi 2025697431 570 RAKEW 574
Cdd:PRK08314 537 QEQEK 541
|
|
| PRK06178 |
PRK06178 |
acyl-CoA synthetase; Validated |
34-571 |
5.35e-64 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 219.53 E-value: 5.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 34 QWGHQEIPAkfnfaNDVVDHWANmekagKRPPRPALWWMngsGEELkwNFRELSEISQRAANVLSGPcGLQRGDRVAVVL 113
Cdd:PRK06178 27 EYPHGERPL-----TEYLRAWAR-----ERPQRPAIIFY---GHVI--TYAELDELSDRFAALLRQR-GVGAGDRVAVFL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 114 SQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSF----------------- 176
Cdd:PRK06178 91 PNCPQFHIVFFGILKLGAVHVPVSPLFREHELSYELNDAGAEVLLALDQLAPVVEQVRAETSLrhvivtsladvlpaept 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 177 LKIKLLVSDNRR--EGWLNFKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSH--------SSLGLKAKMDA 246
Cdd:PRK06178 171 LPLPDSLRAPRLaaAGAIDLLPALRACTAPVPLPPPALDALAALNYTGGTTGMPKGCEHTQrdmvytaaAAYAVAVVGGE 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 247 DSWTgLNVSDTVWtIS--DTGWIVniltsflePWTLGACVFvyLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-D 323
Cdd:PRK06178 251 DSVF-LSFLPEFW-IAgeNFGLLF--------PLFSGATLV--LLARWDAVAFMAAVERYRVTRTVMLVDNAVELMDHpR 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 324 LSRYKFPHLHScyTGGES----LLPETLENWKAKTGLYIREF-YGQTETGlTCRisrTMTV-----------KPGSLGTA 387
Cdd:PRK06178 319 FAEYDLSSLRQ--VRVVSfvkkLNPDYRQRWRALTGSVLAEAaWGMTETH-TCD---TFTAgfqdddfdllsQPVFVGLP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 388 VPHYDVQVID-EQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRgDFWL-LGDRGTKDPEGYFHFIGRTDD 465
Cdd:PRK06178 393 VPGTEFKICDfETGELLPLGAEGEIVVR-TP----SLLKGYWNKPEATAEALR-DGWLhTGDIGKIDEQGFLHYLGRRKE 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 466 IINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEflsHDPDQLTklLQQHVKSVTAPYK 545
Cdd:PRK06178 467 MLKVNGMS-----VFPSEVEALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQLKPG---ADLTAAA--LQAWCRENMAVYK 536
|
570 580
....*....|....*....|....*.
gi 2025697431 546 YPrKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK06178 537 VP-EIRIVDALPMTATGKVRKQDLQA 561
|
|
| FACL_fum10p_like |
cd05926 |
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ... |
81-570 |
2.35e-63 |
|
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.
Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 216.02 E-value: 2.35e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 81 WNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAG 160
Cdd:cd05926 15 LTYADLAELVDDLARQLAAL-GIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEFYLADLGSKLVLTP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEVAQEVD--AVAPDCSFLKIKLLVSDNRREG---WLNFKTLLKDVSNThhcvETGSHEP--AAIYFTSGTSGLPKMAEH 233
Cdd:cd05926 94 KGELGPASraASKLGLAILELALDVGVLIRAPsaeSLSNLLADKKNAKS----EGVPLPDdlALILHTSGTTGRPKGVPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 234 SHSSLGLKAKMDADSWTgLNVSDTVWTISD----TGWIVNILTsflepwTLGACVFVYLLPKFDPQTVLKVLSSYPINSL 309
Cdd:cd05926 170 THRNLAASATNITNTYK-LTPDDRTLVVMPlfhvHGLVASLLS------TLAAGGSVVLPPRFSASTFWPDVRDYNATWY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 310 VGAPLIYRMLLQQDLSRY--KFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETG--LTCRISRTMTVKPGSLG 385
Cdd:cd05926 243 TAVPTIHQILLNRPEPNPesPPPKLRFIRSCSASLPPAVLEALEATFGAPVLEAYGMTEAAhqMTSNPLPPGPRKPGSVG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 386 TAVpHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWLL-GDRGTKDPEGYFHFIGRTD 464
Cdd:cd05926 323 KPV-GVEVRILDEDGEILPPGVVGEICLRGP-----NVTRGYLNNPEANAEAAFKDGWFRtGDLGYLDADGYLFLTGRIK 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 465 DIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLApEFLSHDPDQLTKLLQQHVksvtAPY 544
Cdd:cd05926 397 ELINRGGE-----KISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAAAVVLR-EGASVTEEELRAFCRKHL----AAF 466
|
490 500
....*....|....*....|....*.
gi 2025697431 545 KYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05926 467 KVPKKVYFVDELPKTATGKIQRRKVA 492
|
|
| LC_FACS_like |
cd05935 |
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ... |
82-569 |
3.23e-63 |
|
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.
Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 213.88 E-value: 3.23e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 82 NFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGD 161
Cdd:cd05935 3 TYLELLEVVKKLASFLSN-KGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 162 EvaqevdavapdcsflkikllvsdnrregwlnfktlLKDVsnthhcvetgshepAAIYFTSGTSGLPKMAEHSHSSLGLK 241
Cdd:cd05935 82 E-----------------------------------LDDL--------------ALIPYTSGTTGLPKGCMHTHFSAAAN 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 242 AKMDAdSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFvyLLPKFDPQTVLKVLSSYPINSLVGAP-LIYRMLL 320
Cdd:cd05935 113 ALQSA-VWTGLTPSDVILACLPLFHVTGFVGSLNTAVYVGGTYV--LMARWDRETALELIEKYKVTFWTNIPtMLVDLLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 321 QQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETgltcrISRTMTVKPGS-----LGTAVPHYDVQV 395
Cdd:cd05935 190 TPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGLRFVEGYGLTET-----MSQTHTNPPLRpklqcLGIP*FGVDARV 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 396 ID-EQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEA---NIRG-DFWLLGDRGTKDPEGYFHFIGRTDDIINSS 470
Cdd:cd05935 265 IDiETGRELPPNEVGEIVVR-GP----QIFKGYWNRPEETEEsfiEIKGrRFFRTGDLGYMDEEGYFFFVDRVKRMINVS 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 471 GtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSH-DPDQLTKLLQQHVksvtAPYKYPRK 549
Cdd:cd05935 340 G-----FKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLRPEYRGKvTEEDIIEWAREQM----AAYKYPRE 410
|
490 500
....*....|....*....|
gi 2025697431 550 VEFVLDLPKTITGKIERAKL 569
Cdd:cd05935 411 VEFVDELPRSASGKILWRLL 430
|
|
| AACS_like |
cd05968 |
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ... |
23-571 |
2.66e-62 |
|
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 216.20 E-value: 2.66e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 23 FHINIKKLLSIQW-----------GHQEIPAKF-----NFANDVVDHWAnmekaGKRPPRPALWWMNGSGEELKWNFREL 86
Cdd:cd05968 23 FWGEFVKDVGIEWyeppyqtldlsGGKPWAAWFvggrmNIVEQLLDKWL-----ADTRTRPALRWEGEDGTSRTLTYGEL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 87 SEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGD----- 161
Cdd:cd05968 98 LYEVKRLANGLRA-LGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIVVPIFSGFGKEAAATRLQDAEAKALITADgftrr 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 162 ----EVAQEVDAVAPDCSFLKiKLLVSdnRREGWLNFKTLLKDVSNTH-------HCVETGSHEPAAIYFTSGTSGLPKM 230
Cdd:cd05968 177 grevNLKEEADKACAQCPTVE-KVVVV--RHLGNDFTPAKGRDLSYDEeketagdGAERTESEDPLMIIYTSGTTGKPKG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 231 AEHSHSSLGLKAKMDADSWTGLNVSDTVWTISDTGWIVNiltsflePW------TLGACVFVYL-LPKFD-PQTVLKVLS 302
Cdd:cd05968 254 TVHVHAGFPLKAAQDMYFQFDLKPGDLLTWFTDLGWMMG-------PWlifgglILGATMVLYDgAPDHPkADRLWRMVE 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 303 SYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWK------AKTGLYIREFYGQTETG---LTCRI 373
Cdd:cd05968 327 DHEITHLGLSPTLIRALKPRGDAPVNAHDLSSLRVLGSTGEPWNPEPWNwlfetvGKGRNPIINYSGGTEISggiLGNVL 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 374 SRTmtVKPGSLGTAVPHYDVQVIDEQGNVLPPgKEGDIAIRvKPFrpIGIFSGYVDNPKK---TEANIRGDFWLLGDRGT 450
Cdd:cd05968 407 IKP--IKPSSFNGPVPGMKADVLDESGKPARP-EVGELVLL-APW--PGMTRGFWRDEDRyleTYWSRFDNVWVHGDFAY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 451 KDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlSHDPDQLT 530
Cdd:cd05968 481 YDEEGYFYILGRSDDTINVAGK-----RVGPAEIESVLNAHPAVLESAAIGVPHPVKGEAIVCFVVLKPGV-TPTEALAE 554
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 2025697431 531 KLLQQHVKSVTAPYKyPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05968 555 ELMERVADELGKPLS-PERILFVKDLPKTRNAKVMRRVIRA 594
|
|
| PRK07514 |
PRK07514 |
malonyl-CoA synthase; Validated |
57-570 |
2.74e-62 |
|
malonyl-CoA synthase; Validated
Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 213.58 E-value: 2.74e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 57 MEKAGKRPPRPALWWMNGsgeeLKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPG 136
Cdd:PRK07514 9 LRAAFADRDAPFIETPDG----LRYTYGDLDAASARLANLLVA-LGVKPGDRVAVQVEKSPEALALYLATLRAGAVFLPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLvsDNRREGwlnfkTLL---KDVSNTHHCVETGSH 213
Cdd:PRK07514 84 NTAYTLAELDYFIGDAEPALVVCDPANFAWLSKIAAAAGAPHVETL--DADGTG-----SLLeaaAAAPDDFETVPRGAD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTglnvsdtvWTISDT-----------GWIVNILTSFLEpwtlGA 282
Cdd:PRK07514 157 DLAAILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWR--------FTPDDVlihalpifhthGLFVATNVALLA----GA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVFvyLLPKFDPQTVLKVLSSypINSLVGAPLIY-RMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREF 361
Cdd:PRK07514 225 SMI--FLPKFDPDAVLALMPR--ATVMMGVPTFYtRLLQEPRLTREAAAHMRLFISGSAPLLAETHREFQERTGHAILER 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETG-LTC------RIsrtmtvkPGSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNP 431
Cdd:PRK07514 301 YGMTETNmNTSnpydgeRR-------AGTVGFPLPGVSLRVTDpETGAELPPGEIGMIEVK-------GpnVFKGYWRMP 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 432 KKTEANIRGD-FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:PRK07514 367 EKTAEEFRADgFFITGDLGKIDERGYVHIVGRGKDLIISGG-----YNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEG 441
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 511 VKAFVVLAPEFlSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK07514 442 VTAVVVPKPGA-ALDEAAILAALKGRL----ARFKQPKRVFFVDELPRNTMGKVQKNLLR 496
|
|
| PRK06188 |
PRK06188 |
acyl-CoA synthetase; Validated |
62-578 |
5.20e-57 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 199.83 E-value: 5.20e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 62 KRPPRPALWWMNGSgeelkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLV-----TLGCIRTGLVFMpG 136
Cdd:PRK06188 24 RYPDRPALVLGDTR-----LTYGQLADRISRYIQAFEA-LGLGTGDAVALLSLNRPEVLMAigaaqLAGLRRTALHPL-G 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQmkstDILYRLQSSKARAIVAGD----EVAQEVDAVAPdcsflKIKLLVSDNRREGWLNFKTLLKDVSNTHHCVETGS 212
Cdd:PRK06188 97 SLD----DHAYVLEDAGISTLIVDPapfvERALALLARVP-----SLKHVLTLGPVPDGVDLLAAAAKFGPAPLVAAALP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYFTSGTSGLPKMAEHSHSSLglkakmdadswtglnVSDTVWTISDTGWIVNIltSFLEPWTL----GACV---- 284
Cdd:PRK06188 168 PDIAGLAYTGGTTGKPKGVMGTHRSI---------------ATMAQIQLAEWEWPADP--RFLMCTPLshagGAFFlptl 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 285 ----FVYLLPKFDPQTVLKVLSSYPINSLVGAP-LIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIR 359
Cdd:PRK06188 231 lrggTVIVLAKFDPAEVLRAIEEQRITATFLVPtMIYALLDHPDLRTRDLSSLETVYYGASPMSPVRLAEAIERFGPIFA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTETGLTCRISRT---MTVKP---GSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKK 433
Cdd:PRK06188 311 QYYGQTEAPMVITYLRKrdhDPDDPkrlTSCGRPTPGLRVALLDEDGREVAQGEVGEICVR-GP----LVMDGYWNRPEE 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 434 TEANIRGDfWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVK 512
Cdd:PRK06188 386 TAEAFRDG-WLhTGDVAREDEDGFYYIVDRKKDMIVTGG-----FNVFPREVEDVLAEHPAVAQVAVIGVPDEKWGEAVT 459
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 513 AFVVLAPEfLSHDPDQltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG 578
Cdd:PRK06188 460 AVVVLRPG-AAVDAAE----LQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALRARYWEGRG 520
|
|
| PRK07786 |
PRK07786 |
long-chain-fatty-acid--CoA ligase; Validated |
53-572 |
2.70e-54 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 193.07 E-value: 2.70e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 53 HWANM--EKAGKRPPRPALWWMngsGEELKWnfRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTG 130
Cdd:PRK07786 18 NWVNQlaRHALMQPDAPALRFL---GNTTTW--RELDDRVAALAGALSRR-GVGFGDRVLILMLNRTEFVESVLAANMLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 131 LVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLLKDVSNTHHCVET 210
Cdd:PRK07786 92 AIAVPVNFRLTPPEIAFLVSDCGAHVVVTEAALAPVATAVRDIVPLLSTVVVAGGSSDDSVLGYEDLLAEAGPAHAPVDI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 211 GSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLLP 290
Cdd:PRK07786 172 PNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTCLRTN-GADINSDVGFVGVPLFHIAGIGSMLPGLLLGAPTVIYPLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHsCYTGGESLLPETLENWKAKT--GLYIREFYGQTE-T 367
Cdd:PRK07786 251 AFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLALR-VLSWGAAPASDTLLRQMAATfpEAQILAAFGQTEmS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GLTCRISRTMTV-KPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAirvkpFRPIGIFSGYVDNPKKTEANIRGDFWLLG 446
Cdd:PRK07786 330 PVTCMLLGEDAIrKLGSVGKVIPTVAARVVDENMNDVPVGEVGEIV-----YRAPTLMSGYWNNPEATAEAFAGGWFHSG 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DRGTKDPEGYFHFIGRTDDIINSSGTS-FCryrigpSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHD 525
Cdd:PRK07786 405 DLVRQDEEGYVWVVDRKKDMIISGGENiYC------AEVENVLASHPDIVEVAVIGRADEKWGEVPVAVAAVRNDDAALT 478
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 2025697431 526 PDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PRK07786 479 LEDLAEFLTDRL----ARYKHPKALEIVDALPRNPAGKVLKTELRER 521
|
|
| caiC |
PRK08008 |
putative crotonobetaine/carnitine-CoA ligase; Validated |
58-570 |
3.39e-53 |
|
putative crotonobetaine/carnitine-CoA ligase; Validated
Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 189.51 E-value: 3.39e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWMNGSGEELKWNFRELSEISQRAANV-LSgpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPG 136
Cdd:PRK08008 15 DLADVYGHKTALIFESSGGVVRRYSYLELNEEINRTANLfYS--LGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSD---NRREGWLNFKTLLKDVSNT-HHCVETGS 212
Cdd:PRK08008 93 NARLLREESAWILQNSQASLLVTSAQFYPMYRQIQQEDATPLRHICLTRvalPADDGVSSFTQLKAQQPATlCYAPPLST 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDAdsW-TGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACvFVyLLPK 291
Cdd:PRK08008 173 DDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSA--WqCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGAT-FV-LLEK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLS--------RYKFPHLHscytggesLLPETLENWKAKTGLYIREFYG 363
Cdd:PRK08008 249 YSARAFWGQVCKYRATITECIPMMIRTLMVQPPSandrqhclREVMFYLN--------LSDQEKDAFEERFGVRLLTSYG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 364 QTETgltcrISRTMTVKPG------SLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPFRPIgiFSGYVDNPKKTEAN 437
Cdd:PRK08008 321 MTET-----IVGIIGDRPGdkrrwpSIGRPGFCYEAEIRDDHNRPLPAGEIGEICIKGVPGKTI--FKEYYLDPKATAKV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVV 516
Cdd:PRK08008 394 LEADGWLhTGDTGYVDEEGFFYFVDRRCNMIKRGGEN-----VSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVV 468
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 517 LAP-EFLShdPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK08008 469 LNEgETLS--EEEFFAFCEQNM----AKFKVPSYLEIRKDLPRNCSGKIIKKNLK 517
|
|
| ACS |
cd05966 |
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ... |
42-571 |
4.91e-53 |
|
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 190.85 E-value: 4.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 42 AKFNFANDVVDHWAnmekaGKRPPRPALWWM-NGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWW 120
Cdd:cd05966 50 GKLNISYNCLDRHL-----KERGDKVAIIWEgDEPDQSRTITYRELLREVCRFANVLKS-LGVKKGDRVAIYMPMIPELV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 121 LVTLGCIRTG----LVFmpGTIQMKStdILYRLQSSKARAIVAGDEV---------AQEVDAVAPDCSFLKIKLLVSDNR 187
Cdd:cd05966 124 IAMLACARIGavhsVVF--AGFSAES--LADRINDAQCKLVITADGGyrggkviplKEIVDEALEKCPSVEKVLVVKRTG 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 188 REGWLN------FKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMdadswTGLNV-----SD 256
Cdd:cd05966 200 GEVPMTegrdlwWHDLMAKQSPECEPEWMDSEDPLFILYTSGSTGKPKGVVHTTGGYLLYAAT-----TFKYVfdyhpDD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 257 TVWTISDTGWIvnilT--SFL--EPWTLGACVFVYL-LPKF-DPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-------- 322
Cdd:cd05966 275 IYWCTADIGWI----TghSYIvyGPLANGATTVMFEgTPTYpDPGRYWDIVEKHKVTIFYTAPTAIRALMKFgdewvkkh 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 323 DLSRYKfpHLHSCytgGESLLPETlenWKaktglYIREFYG-----------QTETG---LTCRISRTMTvKPGSLGTAV 388
Cdd:cd05966 351 DLSSLR--VLGSV---GEPINPEA---WM-----WYYEVIGkercpivdtwwQTETGgimITPLPGATPL-KPGSATRPF 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 389 PHYDVQVIDEQGNVLPPGKEGDIAIRvKPFrPiGIFSGYVDNPKKTEANIRGDFW---LLGDRGTKDPEGYFHFIGRTDD 465
Cdd:cd05966 417 FGIEPAILDEEGNEVEGEVEGYLVIK-RPW-P-GMARTIYGDHERYEDTYFSKFPgyyFTGDGARRDEDGYYWITGRVDD 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 466 IINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlsHDPDQLTKLLQQHVKSVTAPYK 545
Cdd:cd05966 494 VINVSG-----HRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAFVTLKDGE--EPSDELRKELRKHVRKEIGPIA 566
|
570 580
....*....|....*....|....*.
gi 2025697431 546 YPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05966 567 TPDKIQFVPGLPKTRSGKIMRRILRK 592
|
|
| PRK07529 |
PRK07529 |
AMP-binding domain protein; Validated |
60-573 |
8.92e-53 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 190.55 E-value: 8.92e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWMNGSG---EELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFmPG 136
Cdd:PRK07529 35 AARHPDAPALSFLLDADpldRPETWTYAELLADVTRTANLLHS-LGVGPGDVVAFLLPNLPETHFALWGGEAAGIAN-PI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTDILYRLQSSKARAIVA-----GDEVAQEVDAVAPDCSFLKIKLLVSDNRR-----------------EGWLNF 194
Cdd:PRK07529 113 NPLLEPEQIAELLRAAGAKVLVTlgpfpGTDIWQKVAEVLAALPELRTVVEVDLARYlpgpkrlavplirrkahARILDF 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 195 KTLLKDVSNTHHCVET--GSHEPAAIYFTSGTSGLPKMAEHSHSSlglkakMDADSWT-----GLNVSDTVwtISDT--- 264
Cdd:PRK07529 193 DAELARQPGDRLFSGRpiGPDDVAAYFHTGGTTGMPKLAQHTHGN------EVANAWLgalllGLGPGDTV--FCGLplf 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 265 ---GWIVNILTsflePWTLGACVfVYLLPK--FDPQTV---LKVLSSYPINSLVGAPLIYRMLLQQ-----DLS--RYKF 329
Cdd:PRK07529 265 hvnALLVTGLA----PLARGAHV-VLATPQgyRGPGVIanfWKIVERYRINFLSGVPTVYAALLQVpvdghDISslRYAL 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 330 phlhscyTGGESLLPETLENWKAKTGLYIREFYGQTETglTCRIS---RTMTVKPGSLGTAVPHYDVQVI--DEQGNVL- 403
Cdd:PRK07529 340 -------CGAAPLPVEVFRRFEAATGVRIVEGYGLTEA--TCVSSvnpPDGERRIGSVGLRLPYQRVRVVilDDAGRYLr 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 404 --PPGKEGDIAIRvKPfrpiGIFSGYVdNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIG 480
Cdd:PRK07529 411 dcAVDEVGVLCIA-GP----NVFSGYL-EAAHNKGLWLEDGWLnTGDLGRIDADGYFWLTGRAKDLIIRGG-----HNID 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 481 PSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQLTKLLQQHVKSVTApykYPRKVEFVLDLPKTI 560
Cdd:PRK07529 480 PAAIEEALLRHPAVALAAAVGRPDAHAGELPVAYVQLKPG-ASATEAELLAFARDHIAERAA---VPKHVRILDALPKTA 555
|
570
....*....|...
gi 2025697431 561 TGKIERAKLRAKE 573
Cdd:PRK07529 556 VGKIFKPALRRDA 568
|
|
| PRK06087 |
PRK06087 |
medium-chain fatty-acid--CoA ligase; |
81-575 |
9.18e-52 |
|
medium-chain fatty-acid--CoA ligase;
Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 186.11 E-value: 9.18e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 81 WNFRELSEISQRAANVLSGpCGLQRGDRVAVvlsQVPEW---WLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAI 157
Cdd:PRK06087 50 YTYSALDHAASRLANWLLA-KGIEPGDRVAF---QLPGWcefTIIYLACLKVGAVSVPLLPSWREAELVWVLNKCQAKMF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 VAGDEVAQ-----EVDAVAPDCSFLKIKLLVSDNRRE-GWLNFKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMA 231
Cdd:PRK06087 126 FAPTLFKQtrpvdLILPLQNQLPQLQQIVGVDKLAPAtSSLSLSQIIADYEPLTTAITTHGDELAAVLFTSGTEGLPKGV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 232 EHSHSSLgLKAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFvyLLPKFDPQTVLKVLSSYPINSLVG 311
Cdd:PRK06087 206 MLTHNNI-LASERAYCARLNLTWQDVFMMPAPLGHATGFLHGVTAPFLIGARSV--LLDIFTPDACLALLEQQRCTCMLG 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 312 A-PLIYRMLLQQDLSRYKFPHLHSCYTGGeSLLPETLENWKAKTGLYIREFYGQTETG------LTCRISRTMtvkpGSL 384
Cdd:PRK06087 283 AtPFIYDLLNLLEKQPADLSALRFFLCGG-TTIPKKVARECQQRGIKLLSVYGSTESSphavvnLDDPLSRFM----HTD 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 385 GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDFWLL-GDRGTKDPEGYFHFIGRT 463
Cdd:PRK06087 358 GYAAAGVEIKVVDEARKTLPPGCEGEEASR-GP----NVFMGYLDEPELTARALDEEGWYYsGDLCRMDEAGYIKITGRK 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 464 DDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDPDQLTKLL-QQHVksvtA 542
Cdd:PRK06087 433 KDIIVRGGEN-----ISSREVEDILLQHPKIHDACVVAMPDERLGERSCAYVVLKAPHHSLTLEEVVAFFsRKRV----A 503
|
490 500 510
....*....|....*....|....*....|...
gi 2025697431 543 PYKYPRKVEFVLDLPKTITGKIERAKLRaKEWK 575
Cdd:PRK06087 504 KYKYPEHIVVIDKLPRTASGKIQKFLLR-KDIM 535
|
|
| PRK08276 |
PRK08276 |
long-chain-fatty-acid--CoA ligase; Validated |
72-579 |
3.33e-51 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 183.57 E-value: 3.33e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 72 MNGSGEElkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQS 151
Cdd:PRK08276 5 MAPSGEV--VTYGELEARSNRLAHGLRA-LGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 152 SKARAIV---AGDEVAQEVDAVAP-DCSFLkiklLVSDNRREGWLNFKTLLKDVSNThhcveTGSHEPA--AIYFTSGTS 225
Cdd:PRK08276 82 SGAKVLIvsaALADTAAELAAELPaGVPLL----LVVAGPVPGFRSYEEALAAQPDT-----PIADETAgaDMLYSSGTT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 226 GLPK----MAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISD-------TGWIVNILTsflepwtLGACVFVylLPKFDP 294
Cdd:PRK08276 153 GRPKgikrPLPGLDPDEAPGMMLALLGFGMYGGPDSVYLSPAplyhtapLRFGMSALA-------LGGTVVV--MEKFDA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 295 QTVLKVLSSYPINSLVGAPLIY-RML-LQQDL-SRYKFPHLHSCYTGGESLLPET----LENWkaktGLYIREFYGQTET 367
Cdd:PRK08276 224 EEALALIERYRVTHSQLVPTMFvRMLkLPEEVrARYDVSSLRVAIHAAAPCPVEVkramIDWW----GPIIHEYYASSEG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GLTCRI-SRTMTVKPGSLGTAVpHYDVQVIDEQGNVLPPGKEGDIAIRvkpfRPIGIFSgYVDNPKKTEANIRGDFWL-L 445
Cdd:PRK08276 300 GGVTVItSEDWLAHPGSVGKAV-LGEVRILDEDGNELPPGEIGTVYFE----MDGYPFE-YHNDPEKTAAARNPHGWVtV 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 446 GDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPeflSHD 525
Cdd:PRK08276 374 GDVGYLDEDGYLYLTDRKSDMIISGGVN-----IYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVQPAD---GAD 445
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 526 P-DQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSGQ 579
Cdd:PRK08276 446 AgDALAAELIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRDRYWEGRQR 500
|
|
| PRK12583 |
PRK12583 |
acyl-CoA synthetase; Provisional |
60-570 |
3.59e-51 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 184.59 E-value: 3.59e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWmngSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK12583 28 VARFPDREALVV---RHQALRYTWRQLADAVDRLARGLLA-LGVQPGDRVGIWAPNCAEWLLTQFATARIGAILVNINPA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKAR------------------AIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLLKD- 200
Cdd:PRK12583 104 YRASELEYALGQSGVRwvicadafktsdyhamlqELLPGLAEGQPGALACERLPELRGVVSLAPAPPPGFLAWHELQARg 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 201 --VSNTHHCVETGS---HEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSwTGLNVSDTVWTISDTGWIVNILTSFL 275
Cdd:PRK12583 184 etVSREALAERQASldrDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAES-LGLTEHDRLCVPVPLYHCFGMVLANL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 276 EPWTLGACVfVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLEnwKAKT 354
Cdd:PRK12583 263 GCMTVGACL-VYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHpQRGNFDLSSLRTGIMAGAPCPIEVMR--RVMD 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 355 GLYIREF---YGQTETG----LTCRiSRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAirvkpFRPIGIFSGY 427
Cdd:PRK12583 340 EMHMAEVqiaYGMTETSpvslQTTA-ADDLERRVETVGRTQPHLEVKVVDPDGATVPRGEIGELC-----TRGYSVMKGY 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 428 VDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSFCryrigPSEVENALMEHPAVAETVVISSPDPT 506
Cdd:PRK12583 414 WNNPEATAESIDEDGWMhTGDLATMDEQGYVRIVGRSKDMIIRGGENIY-----PREIEEFLFTHPAVADVQVFGVPDEK 488
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 507 RGEVVKAFVVLAP-EFLSHDPdqltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK12583 489 YGEEIVAWVRLHPgHAASEEE------LREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMR 547
|
|
| PRK06839 |
PRK06839 |
o-succinylbenzoate--CoA ligase; |
59-569 |
6.60e-51 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 182.75 E-value: 6.60e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 59 KAGKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTI 138
Cdd:PRK06839 11 RAYLHPDRIAI-----ITEEEEMTYKQLHEYVSKVAAYLIYELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 139 QMKSTDILYRLQSSKARAIVAGDEVA------QEVDAVAPDCSFLKIKLLvSDNRREGWlnfktllkdvsnthhcVETGS 212
Cdd:PRK06839 86 RLTENELIFQLKDSGTTVLFVEKTFQnmalsmQKVSYVQRVISITSLKEI-EDRKIDNF----------------VEKNE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYFTSGTSGLPKMAEHSHSSLGLKA--KMDADSWTGLNVSDTVWTISDTGWIvNILTsfLEPWTLGACVFVylLP 290
Cdd:PRK06839 149 SASFIICYTSGTTGKPKGAVLTQENMFWNAlnNTFAIDLTMHDRSIVLLPLFHIGGI-GLFA--FPTLFAGGVIIV--PR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLlPETLENWKAKTGLYIREFYGQTETGL 369
Cdd:PRK06839 224 KFEPTKALSMIEKHKVTVVMGVPTIHQALINCsKFETTNLQSVRWFYNGGAPC-PEELMREFIDRGFLFGQGFGMTETSP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 370 TCRI--SRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDFWLLGD 447
Cdd:PRK06839 303 TVFMlsEEDARRKVGSIGKPVLFCDYELIDENKNKVEVGEVGELLIR-GP----NVMKEYWNRPDATEETIQDGWLCTGD 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 448 RGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDPD 527
Cdd:PRK06839 378 LARVDEDGFVYIVGRKKEMIISGGEN-----IYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVKKSSSVLIEKD 452
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2025697431 528 qltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK06839 453 -----VIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQL 489
|
|
| FACL_like_6 |
cd05922 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
102-570 |
8.00e-51 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 181.48 E-value: 8.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 102 GLQRGDRVAVVLSQVPEW-WL---VTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSfl 177
Cdd:cd05922 14 GGVRGERVVLILPNRFTYiELsfaVAYAGGRLGLVFVPLNPTLKESVLRYLVADAGGRIVLADAGAADRLRDALPASP-- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 178 kIKLLVSDNrrEGWLNFKTLLKDVSNTHHcvetgshEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDAdSWTGLNVSDT 257
Cdd:cd05922 92 -DPGTVLDA--DGIRAARASAPAHEVSHE-------DLALLLYTSGSTGSPKLVRLSHQNLLANARSIA-EYLGITADDR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 258 VWTISDTGWI--VNILTSFLepwTLGACVFVYLLPKFDpQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSC 335
Cdd:cd05922 161 ALTVLPLSYDygLSVLNTHL---LRGATLVLTNDGVLD-DAFWEDLREHGATGLAGVPSTYAMLTRLGFDPAKLPSLRYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 336 YTGGESLLPETLENWKAK---TGLYIreFYGQTETgltcriSRTMTV--------KPGSLGTAVPHYDVQVIDEQGNVLP 404
Cdd:cd05922 237 TQAGGRLPQETIARLRELlpgAQVYV--MYGQTEA------TRRMTYlpperileKPGSIGLAIPGGEFEILDDDGTPTP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 405 PGKEGDIAIRvkpfRPIGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEV 484
Cdd:cd05922 309 PGEPGEIVHR----GPNVMKGYWNDPPYRRKEGRGGGVLHTGDLARRDEDGFLFIVGRRDRMIKLFG-----NRISPTEI 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 485 ENALMEHPAVAETVVISSPDPTrGEVVKAFVVLAPEFlshDPDQLTKllqqHVKSVTAPYKYPRKVEFVLDLPKTITGKI 564
Cdd:cd05922 380 EAAARSIGLIIEAAAVGLPDPL-GEKLALFVTAPDKI---DPKDVLR----SLAERLPPYKVPATVRVVDELPLTASGKV 451
|
....*.
gi 2025697431 565 ERAKLR 570
Cdd:cd05922 452 DYAALR 457
|
|
| CHC_CoA_lg |
cd05903 |
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ... |
83-571 |
1.40e-50 |
|
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.
Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 180.27 E-value: 1.40e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVvlsQVPEWW---LVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVA 159
Cdd:cd05903 4 YSELDTRADRLAAGLAA-LGVGPGDVVAF---QLPNWWefaVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 160 GDEVAQEVDAVAPDcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshEPAAIYFTSGTSGLPKMAEHSHSSLG 239
Cdd:cd05903 80 PERFRQFDPAAMPD----------------------------------------AVALLLFTSGTTGEPKGVMHSHNTLS 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 240 LKAKMDADSWtGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVfvYLLPKFDPQTVLKVLSSYPINSLVGA-PLIYRM 318
Cdd:cd05903 120 ASIRQYAERL-GLGPGDVFLVASPMAHQTGFVYGFTLPLLLGAPV--VLQDIWDPDKALALMREHGVTFMMGAtPFLTDL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 319 LLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTET-GLTCRISRTMTVKP-GSLGTAVPHYDVQVI 396
Cdd:cd05903 197 LNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAKVCSAYGSTECpGAVTSITPAPEDRRlYTDGRPLPGVEIKVV 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 397 DEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcr 476
Cdd:cd05903 277 DDTGATLAPGVEGELLSRGP-----SVFLGYLDRPDLTADAAPEGWFRTGDLARLDEDGYLRITGRSKDIIIRGGEN--- 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 477 yrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQLTKLLQQHvksVTAPYKYPRKVEFVLDL 556
Cdd:cd05903 349 --IPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSG-ALLTFDELVAYLDRQ---GVAKQYWPERLVHVDDL 422
|
490
....*....|....*
gi 2025697431 557 PKTITGKIERAKLRA 571
Cdd:cd05903 423 PRTPSGKVQKFRLRE 437
|
|
| PRK06155 |
PRK06155 |
crotonobetaine/carnitine-CoA ligase; Provisional |
78-571 |
8.04e-50 |
|
crotonobetaine/carnitine-CoA ligase; Provisional
Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 180.72 E-value: 8.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAI 157
Cdd:PRK06155 44 GTRWTYAEAARAAAAAAHALAA-AGVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAVPINTALRGPQLEHILRNSGARLL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 VAGDEVAQEVDAV-APDCSFLKIKLLVSDNRREGWLNFKTL-LKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSH 235
Cdd:PRK06155 123 VVEAALLAALEAAdPGDLPLPAVWLLDAPASVSVPAGWSTApLPPLDAPAPAAAVQPGDTAAILYTSGTTGPSKGVCCPH 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 236 SSLGLKAKMDADSwTGLNVSDTVWTISDTgWIVNILTSFLEPWTLGACVFVylLPKFDPQTVLKVLSSY--PINSLVGAp 313
Cdd:PRK06155 203 AQFYWWGRNSAED-LEIGADDVLYTTLPL-FHTNALNAFFQALLAGATYVL--EPRFSASGFWPAVRRHgaTVTYLLGA- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 314 lIYRMLLQQDLSRYKFPH-LHSCYTGGESllPETLENWKAKTGLYIREFYGQTETGLTCRISRTmTVKPGSLGTAVPHYD 392
Cdd:PRK06155 278 -MVSILLSQPARESDRAHrVRVALGPGVP--AALHAAFRERFGVDLLDGYGSTETNFVIAVTHG-SQRPGSMGRLAPGFE 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 393 VQVIDEQGNVLPPGKEGDIAIRVKPfrPIGIFSGYVDNPKKTEANIRgDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSG 471
Cdd:PRK06155 354 ARVVDEHDQELPDGEPGELLLRADE--PFAFATGYFGMPEKTVEAWR-NLWFhTGDRVVRDADGWFRFVDRIKDAIRRRG 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 472 TSFCRYrigpsEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQLTKllqqHVKSVTAPYKYPRKVE 551
Cdd:PRK06155 431 ENISSF-----EVEQVLLSHPAVAAAAVFPVPSELGEDEVMAAVVLRDG-TALEPVALVR----HCEPRLAYFAVPRYVE 500
|
490 500
....*....|....*....|
gi 2025697431 552 FVLDLPKTITGKIERAKLRA 571
Cdd:PRK06155 501 FVAALPKTENGKVQKFVLRE 520
|
|
| ttLC_FACS_AlkK_like |
cd12119 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
73-570 |
1.35e-49 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.
Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 179.36 E-value: 1.35e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 73 NGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLsqvpewW-----LVT-LGCIRTGLVFMPGTIQMKSTDIL 146
Cdd:cd12119 18 THEGEVHRYTYAEVAERARRLANALRR-LGVKPGDRVATLA------WnthrhLELyYAVPGMGAVLHTINPRLFPEQIA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 147 YRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRR------EGWLNFKTLLKDVSNTHHCVETGSHEPAAIYF 220
Cdd:cd12119 91 YIINHAEDRVVFVDRDFLPLLEAIAPRLPTVEHVVVMTDDAAmpepagVGVLAYEELLAAESPEYDWPDFDENTAAAICY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 221 TSGTSGLPKMAEHSHSSLGLKA--KMDADSwTGLNVSDTVWTISD----TGWIVniltSFLEPWTlGACvFVYLLPKFDP 294
Cdd:cd12119 171 TSGTTGNPKGVVYSHRSLVLHAmaALLTDG-LGLSESDVVLPVVPmfhvNAWGL----PYAAAMV-GAK-LVLPGPYLDP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 295 QTVLKVLSSYPINSLVGAPLIYRMLLQ-QDLSRYKFPHLHSCYTGGeSLLPETLENWKAKTGLYIREFYGQTETGLTCRI 373
Cdd:cd12119 244 ASLAELIEREGVTFAAGVPTVWQGLLDhLEANGRDLSSLRRVVIGG-SAVPRSLIEAFEERGVRVIHAWGMTETSPLGTV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 374 SRTMTVKPG-----------SLGTAVPHYDVQVIDEQGNVLP-PGKE-GDIAIRvKPFrpigIFSGYVDNPKKTEANIRG 440
Cdd:cd12119 323 ARPPSEHSNlsedeqlalraKQGRPVPGVELRIVDDDGRELPwDGKAvGELQVR-GPW----VTKSYYKNDEESEALTED 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 441 DFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPE 520
Cdd:cd12119 398 GWLRTGDVATIDEDGYLTITDRSKDVIKSGGE-----WISSVELENAIMAHPAVAEAAVIGVPHPKWGERPLAVVVLKEG 472
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 2025697431 521 flsHDPDQltKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd12119 473 ---ATVTA--EELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALR 517
|
|
| PRK06710 |
PRK06710 |
long-chain-fatty-acid--CoA ligase; Validated |
38-575 |
3.84e-49 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 179.07 E-value: 3.84e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 38 QEIPAKFNFANDVVDHWANmEKAGKRPPRPALWWMngsGEELkwNFRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVP 117
Cdd:PRK06710 13 EEIPSTISYDIQPLHKYVE-QMASRYPEKKALHFL---GKDI--TFSVFHDKVKRFANYLQ-KLGVEKGDRVAIMLPNCP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 118 EWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVApdcSFLKIKLLVSdNRREGWLNF--- 194
Cdd:PRK06710 86 QAVIGYYGTLLAGGIVVQTNPLYTERELEYQLHDSGAKVILCLDLVFPRVTNVQ---SATKIEHVIV-TRIADFLPFpkn 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 195 ----------KTLLKDVSNTHHC---------VETGSHEP-------AAIYFTSGTSGLPKMAEHSHSSLglkakmdads 248
Cdd:PRK06710 162 llypfvqkkqSNLVVKVSESETIhlwnsvekeVNTGVEVPcdpendlALLQYTGGTTGFPKGVMLTHKNL---------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 249 wtglnVSDTVWTISdtgWIVNILTSflEPWTLGACVFVY-------------------LLPKFDPQTVLKVLSSYPINSL 309
Cdd:PRK06710 232 -----VSNTLMGVQ---WLYNCKEG--EEVVLGVLPFFHvygmtavmnlsimqgykmvLIPKFDMKMVFEAIKKHKVTLF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 310 VGAPLIYRMLLQQDLSR-YKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTVK-PGSLGTA 387
Cdd:PRK06710 302 PGAPTIYIALLNSPLLKeYDISSIRACISGSAPLPVEVQEKFETVTGGKLVEGYGLTESSPVTHSNFLWEKRvPGSIGVP 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 388 VPHYDVQVID-EQGNVLPPGKEGDIAIRVKPfrpigIFSGYVDNPKKTEANIRgDFWL-LGDRGTKDPEGYFHFIGRTDD 465
Cdd:PRK06710 382 WPDTEAMIMSlETGEALPPGEIGEIVVKGPQ-----IMKGYWNKPEETAAVLQ-DGWLhTGDVGYMDEDGFFYVKDRKKD 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 466 IINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDPDqltklLQQHVKSVTAPYK 545
Cdd:PRK06710 456 MIVASG-----FNVYPREVEEVLYEHEKVQEVVTIGVPDPYRGETVKAFVVLKEGTECSEEE-----LNQFARKYLAAYK 525
|
570 580 590
....*....|....*....|....*....|
gi 2025697431 546 YPRKVEFVLDLPKTITGKIERAKLRAKEWK 575
Cdd:PRK06710 526 VPKVYEFRDELPKTTVGKILRRVLIEEEKR 555
|
|
| ttLC_FACS_AEE21_like |
cd12118 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ... |
78-571 |
1.16e-48 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.
Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 176.34 E-value: 1.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAI 157
Cdd:cd12118 27 DRRYTWRQTYDRCRRLASALAA-LGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLDAEEIAFILRHSEAKVL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 VAgdevaqevdavapDCSFLKIKLLVSDNRREGWLnfktllkdvsnthhcVETGSHEPAAIYFTSGTSGLPKMAEHSHSS 237
Cdd:cd12118 106 FV-------------DREFEYEDLLAEGDPDFEWI---------------PPADEWDPIALNYTSGTTGRPKGVVYHHRG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 238 LGLKAKMDADSWtGLNvSDTV--WTISD---TGWivniltSFlePWTLGA-CVFVYLLPKFDPQTVLKVLSSYPINSLVG 311
Cdd:cd12118 158 AYLNALANILEW-EMK-QHPVylWTLPMfhcNGW------CF--PWTVAAvGGTNVCLRKVDAKAIYDLIEKHKVTHFCG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 312 APLIYRMLLQ-QDLSRYKFPHLHSCYTGGESLLPETLENWKAKtGLYIREFYGQTET---GLTCRISRTMTVKPGSL--- 384
Cdd:cd12118 228 APTVLNMLANaPPSDARPLPHRVHVMTAGAPPPAAVLAKMEEL-GFDVTHVYGLTETygpATVCAWKPEWDELPTEErar 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 385 -----GTAVPHYD-VQVIDEQGNVLPP--GKE-GDIAirvkpFRPIGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEG 455
Cdd:cd12118 307 lkarqGVRYVGLEeVDVLDPETMKPVPrdGKTiGEIV-----FRGNIVMKGYLKNPEATAEAFRGGWFHSGDLAVIHPDG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 456 YFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlSHDPDQLTKLLQQ 535
Cdd:cd12118 382 YIEIKDRSKDIIISGGEN-----ISSVEVEGVLYKHPAVLEAAVVARPDEKWGEVPCAFVELKEGA-KVTEEEIIAFCRE 455
|
490 500 510
....*....|....*....|....*....|....*.
gi 2025697431 536 HVksvtAPYKYPRKVEFVlDLPKTITGKIERAKLRA 571
Cdd:cd12118 456 HL----AGFMVPKTVVFG-ELPKTSTGKIQKFVLRD 486
|
|
| A_NRPS |
cd05930 |
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ... |
64-569 |
2.04e-48 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 174.64 E-value: 2.04e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWwLVT-LGCIRTGLVFMPgtiqmks 142
Cdd:cd05930 1 PDAVAVVD-----GDQSLTYAELDARANRLARYLRE-RGVGPGDLVAVLLERSLEM-VVAiLAVLKAGAAYVP------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 143 tdilyrlqsskaraivagdevaqeVDAVAPDcsflkikllvsdNRREgwlnfkTLLKDvSNTHHCVETGSHePAAIYFTS 222
Cdd:cd05930 67 ------------------------LDPSYPA------------ERLA------YILED-SGAKLVLTDPDD-LAYVIYTS 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 223 GTSGLPKMAEHSHSSLG--LKAKMDAdswTGLNVSDTVWTISDTGWIVnILTSFLEPWTLGACVfvYLLPK---FDPQTV 297
Cdd:cd05930 103 GSTGKPKGVMVEHRGLVnlLLWMQEA---YPLTPGDRVLQFTSFSFDV-SVWEIFGALLAGATL--VVLPEevrKDPEAL 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 298 LKVLSSYPINSLVGAPLIYRMLLQqDLSRYKFPHLHSCYTGGESLLPETLENW-KAKTGLYIREFYGQTETG---LTCRI 373
Cdd:cd05930 177 ADLLAEEGITVLHLTPSLLRLLLQ-ELELAALPSLRLVLVGGEALPPDLVRRWrELLPGARLVNLYGPTEATvdaTYYRV 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 374 SR-TMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGDFWLL------- 445
Cdd:cd05930 256 PPdDEEDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIG-----GAGLARGYLNRPELTAERFVPNPFGPgermyrt 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 446 GDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPeflshD 525
Cdd:cd05930 331 GDLVRWLPDGNLEFLGRIDDQVKIRG-----YRIELGEIEAALLAHPGVREAAVVAREDGDGEKRLVAYVVPDE-----G 400
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2025697431 526 PDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd05930 401 GELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
|
|
| ACLS-CaiC |
cd17637 |
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ... |
214-566 |
2.40e-48 |
|
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 171.30 E-value: 2.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLgLKAKMDADSWTGLNVSDTVWTI----SDTGwiVNILTSFLEpwtLGACVFVylL 289
Cdd:cd17637 1 DPFVIIHTAAVAGRPRGAVLSHGNL-IAANLQLIHAMGLTEADVYLNMlplfHIAG--LNLALATFH---AGGANVV--M 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKFDPQTVLKVLSSYPInSLVG--APLIYRMLLQQDLSRYKFPHLHSCyTGGESllPETLENWKAKTGLYIREFYGQTET 367
Cdd:cd17637 73 EKFDPAEALELIEEEKV-TLMGsfPPILSNLLDAAEKSGVDLSSLRHV-LGLDA--PETIQRFEETTGATFWSLYGQTET 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 -GLTCrISRTmTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDFWLLG 446
Cdd:cd17637 149 sGLVT-LSPY-RERPGSAGRPGPLVRVRIVDDNDRPVPAGETGEIVVR-GP----LVFQGYWNLPELTAYTFRNGWHHTG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DRGTKDPEGYFHFIGRT--DDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlSH 524
Cdd:cd17637 222 DLGRFDEDGYLWYAGRKpeKELIKPGGEN-----VYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKAVCVLKPGA-TL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2025697431 525 DPDQLTKllqqHVKSVTAPYKYPRKVEFVLDLPKTITGKIER 566
Cdd:cd17637 296 TADELIE----FVGSRIARYKKPRYVVFVEALPKTADGSIDR 333
|
|
| Firefly_Luc |
cd17642 |
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ... |
78-570 |
3.51e-47 |
|
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 173.10 E-value: 3.51e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAI 157
Cdd:cd17642 42 GVNYSYAEYLEMSVRLAEALKK-YGLKQNDRIAVCSENSLQFFLPVIAGLFIGVGVAPTNDIYNERELDHSLNISKPTIV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 VAGDEVAQEVDAVAPDCSFLK-IKLLVSDNRREGWLNFKTLLKdvSNTHHCVETGSHEP---------AAIYFTSGTSGL 227
Cdd:cd17642 121 FCSKKGLQKVLNVQKKLKIIKtIIILDSKEDYKGYQCLYTFIT--QNLPPGFNEYDFKPpsfdrdeqvALIMNSSGSTGL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 228 PKMAEHSHSSLGLKAKMDADSWTGLNVSDTVwtisdtgwivNILTSFlePW--------TLG--ACVF-VYLLPKFDPQT 296
Cdd:cd17642 199 PKGVQLTHKNIVARFSHARDPIFGNQIIPDT----------AILTVI--PFhhgfgmftTLGylICGFrVVLMYKFEEEL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 297 VLKVLSSYPINSLVGAPLIYRMLLQQDL-SRYKFPHLHSCYTGGESLLPETLENWKAKTGL-YIREFYGQTETGLTCRIS 374
Cdd:cd17642 267 FLRSLQDYKVQSALLVPTLFAFFAKSTLvDKYDLSNLHEIASGGAPLSKEVGEAVAKRFKLpGIRQGYGLTETTSAILIT 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 375 RTMTVKPGSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAirvkpFRPIGIFSGYVDNPKKTEANIRGDFWL-LGDRGTKD 452
Cdd:cd17642 347 PEGDDKPGAVGKVVPFFYAKVVDlDTGKTLGPNERGELC-----VKGPMIMKGYVNNPEATKALIDKDGWLhSGDIAYYD 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 453 PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLapeflsHDPDQLT-K 531
Cdd:cd17642 422 EDGHFFIVDRLKSLIKYKG-----YQVPPAELESILLQHPKIFDAGVAGIPDEDAGELPAAVVVL------EAGKTMTeK 490
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 2025697431 532 LLQQHVKSVTAPYKYPR-KVEFVLDLPKTITGKIERAKLR 570
Cdd:cd17642 491 EVMDYVASQVSTAKRLRgGVKFVDEVPKGLTGKIDRRKIR 530
|
|
| prpE |
PRK10524 |
propionyl-CoA synthetase; Provisional |
45-571 |
3.78e-47 |
|
propionyl-CoA synthetase; Provisional
Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 174.75 E-value: 3.78e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 45 NFANDVVDHWAnmekaGKRPPRPALWWMNG-SGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVT 123
Cdd:PRK10524 53 NLCHNAVDRHL-----AKRPEQLALIAVSTeTDEERTYTFRQLHDEVNRMAAMLRS-LGVQRGDRVLIYMPMIAEAAFAM 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 124 LGCIRTG----LVFmpGTiqMKSTDILYRLQSSKARAIVAGDEVAQE---------VDAVAPDCSFLKIKLLVSD----- 185
Cdd:PRK10524 127 LACARIGaihsVVF--GG--FASHSLAARIDDAKPVLIVSADAGSRGgkvvpykplLDEAIALAQHKPRHVLLVDrglap 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 186 -NRREGW-LNFKTLLKDVSNTHHCVE-TGSHEPAAIYFTSGTSGLPKMAEHSHS--SLGLKAKMDadSWTGLNVSDTVWT 260
Cdd:PRK10524 203 mARVAGRdVDYATLRAQHLGARVPVEwLESNEPSYILYTSGTTGKPKGVQRDTGgyAVALATSMD--TIFGGKAGETFFC 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 261 ISDTGWIVNILTSFLEPWTLGACVFVY----LLPkfDPQTVLKVLSSYPINSLVGAPLIYRMLLQQD---LSRYKFPHLH 333
Cdd:PRK10524 281 ASDIGWVVGHSYIVYAPLLAGMATIMYeglpTRP--DAGIWWRIVEKYKVNRMFSAPTAIRVLKKQDpalLRKHDLSSLR 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 334 SCYTGGESLlPETLENWKAKT-GLYIREFYGQTETG---LT-CRISRTMTVKPGSLGTAVPHYDVQVIDEQ-GNVLPPGK 407
Cdd:PRK10524 359 ALFLAGEPL-DEPTASWISEAlGVPVIDNYWQTETGwpiLAiARGVEDRPTRLGSPGVPMYGYNVKLLNEVtGEPCGPNE 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 408 EGDIAIRvkPFRPIGIFSgyvdnpkkteaNIRGD-------FWLLGDR--------GTKDPEGYFHFIGRTDDIINSSGt 472
Cdd:PRK10524 438 KGVLVIE--GPLPPGCMQ-----------TVWGDddrfvktYWSLFGRqvystfdwGIRDADGYYFILGRTDDVINVAG- 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 473 sfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDPDQLTKL---LQQHVKSVTAPYKYPRK 549
Cdd:PRK10524 504 ----HRLGTREIEESISSHPAVAEVAVVGVKDALKGQVAVAFVVPKDSDSLADREARLALekeIMALVDSQLGAVARPAR 579
|
570 580
....*....|....*....|..
gi 2025697431 550 VEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK10524 580 VWFVSALPKTRSGKLLRRAIQA 601
|
|
| PRK13390 |
PRK13390 |
acyl-CoA synthetase; Provisional |
64-570 |
1.07e-46 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 171.34 E-value: 1.07e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALWwMNGSGEELkwNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKST 143
Cdd:PRK13390 11 PDRPAVI-VAETGEQV--SYRQLDDDSAALARVLYD-AGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 144 DILYRLQSSKARAIVAG---DEVAQEVDAVAPdcsfLKIKLlvsDNRREGWLNFKTLLKDVSnthhcvETGSHEP--AAI 218
Cdd:PRK13390 87 EADYIVGDSGARVLVASaalDGLAAKVGADLP----LRLSF---GGEIDGFGSFEAALAGAG------PRLTEQPcgAVM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 219 YFTSGTSGLPK-----MAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISDtgwivnILTSFLEPW-----TLGACVFvyL 288
Cdd:PRK13390 154 LYSSGTTGFPKgiqpdLPGRDVDAPGDPIVAIARAFYDISESDIYYSSAP------IYHAAPLRWcsmvhALGGTVV--L 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 289 LPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQD---LSRYKFPHLHSCYTGGESL---LPETLENWkakTGLYIREFY 362
Cdd:PRK13390 226 AKRFDAQATLGHVERYRITVTQMVPTMFVRLLKLDadvRTRYDVSSLRAVIHAAAPCpvdVKHAMIDW---LGPIVYEYY 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTET-GLTCRISRTMTVKPGSLGTAVPHyDVQVIDEQGNVLPPGKEGDIAIRVK--PFRpigifsgYVDNPKKTEA--N 437
Cdd:PRK13390 303 SSTEAhGMTFIDSPDWLAHPGSVGRSVLG-DLHICDDDGNELPAGRIGTVYFERDrlPFR-------YLNDPEKTAAaqH 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVV 516
Cdd:PRK13390 375 PAHPFWTtVGDLGSVDEDGYLYLADRKSFMIISGGVN-----IYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIQ 449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 517 LAPEFlshDP-DQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK13390 450 LVEGI---RGsDELARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
|
|
| FACL_like_2 |
cd05917 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
213-570 |
2.23e-46 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 166.30 E-value: 2.23e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYFTSGTSGLPKMAEHSHSSLglkakmdadswtgLNVSDTV-----WTISDT-----------GWIVNILTSFle 276
Cdd:cd05917 2 DDVINIQFTSGTTGSPKGATLTHHNI-------------VNNGYFIgerlgLTEQDRlcipvplfhcfGSVLGVLACL-- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 277 pwTLGACVfVYLLPKFDPQTVLKVLSSYPINSLVGAPLIY-RMLLQQDLSRYKFPHLHSCYTGGESLLPETLEnwKAKTG 355
Cdd:cd05917 67 --THGATM-VFPSPSFDPLAVLEAIEKEKCTALHGVPTMFiAELEHPDFDKFDLSSLRTGIMAGAPCPPELMK--RVIEV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 356 LYIREF---YGQTETGLTCRISRT---MTVKPGSLGTAVPHYDVQVIDEQGNVLPP-GKEGDIAIRvkpfrPIGIFSGYV 428
Cdd:cd05917 142 MNMKDVtiaYGMTETSPVSTQTRTddsIEKRVNTVGRIMPHTEAKIVDPEGGIVPPvGVPGELCIR-----GYSVMKGYW 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 429 DNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTR 507
Cdd:cd05917 217 NDPEKTAEAIDGDGWLhTGDLAVMDEDGYCRIVGRIKDMIIRGGEN-----IYPREIEEFLHTHPKVSDVQVVGVPDERY 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 508 GEVVKAFVVLAPEFLSHDPDqltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05917 292 GEEVCAWIRLKEGAELTEED-----IKAYCKGKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
|
|
| PRK05605 |
PRK05605 |
long-chain-fatty-acid--CoA ligase; Validated |
64-571 |
2.03e-45 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 169.03 E-value: 2.03e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALWWMngsGEELKWnfRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKST 143
Cdd:PRK05605 46 GDRPALDFF---GATTTY--AELGKQVRRAAAGLRA-LGVRPGDRVAIVLPNCPQHIVAFYAVLRLGAVVVEHNPLYTAH 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 144 DILYRLQSSKARAIVAGDEVAQEVDAVAPDCSF-----------------LKIKLLVSDNRR---------EGWLNFKTL 197
Cdd:PRK05605 120 ELEHPFEDHGARVAIVWDKVAPTVERLRRTTPLetivsvnmiaampllqrLALRLPIPALRKaraaltgpaPGTVPWETL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 198 LKD----VSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMdADSWT-GLNVSDTVwtisdtgwIVNILT 272
Cdd:PRK05605 200 VDAaiggDGSDVSHPRPTPDDVALILYTSGTTGKPKGAQLTHRNLFANAAQ-GKAWVpGLGDGPER--------VLAALP 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 273 SF----LepwTLGACVFVY------LLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ------DLS--RYKFphlhs 334
Cdd:PRK05605 271 MFhaygL---TLCLTLAVSiggelvLLPAPDIDLILDAMKKHPPTWLPGVPPLYEKIAEAaeergvDLSgvRNAF----- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 335 cyTGGESLLPETLENWKAKTGLYIREFYGQTETG-LTCRISRTMTVKPGSLGTAVPHYDVQVIDEQ--GNVLPPGKEGDI 411
Cdd:PRK05605 343 --SGAMALPVSTVELWEKLTGGLLVEGYGLTETSpIIVGNPMSDDRRPGYVGVPFPDTEVRIVDPEdpDETMPDGEEGEL 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 412 AIRvkpfrpiG--IFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALM 489
Cdd:PRK05605 421 LVR-------GpqVFKGYWNRPEETAKSFLDGWFRTGDVVVMEEDGFIRIVDRIKELIITGG-----FNVYPAEVEEVLR 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 490 EHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK05605 489 EHPGVEDAAVVGLPREDGSEEVVAAVVLEPG-AALDPEG----LRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRRREV 563
|
..
gi 2025697431 570 RA 571
Cdd:PRK05605 564 RE 565
|
|
| 4CL |
cd05904 |
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ... |
58-569 |
2.70e-45 |
|
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.
Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 167.41 E-value: 2.70e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALwwMNGS-GEELkwNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPG 136
Cdd:cd05904 13 LFASAHPSRPAL--IDAAtGRAL--TYAELERRVRRLAAGLAK-RGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTDILYRLQSSKARAIVAgdeVAQEVDAVAPdcsfLKIKLLVSDNRREGWLNFKTLLKDVSNTHHC-VETGSHEP 215
Cdd:cd05904 88 NPLSTPAEIAKQVKDSGAKLAFT---TAELAEKLAS----LALPVVLLDSAEFDSLSFSDLLFEADEAEPPvVVIKQDDV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTV-------WTISDTGWIVNILTSflepwtLGACVFVyl 288
Cdd:cd05904 161 AALLYSSGTTGRSKGVMLTHRNLIAMVAQFVAGEGSNSDSEDVflcvlpmFHIYGLSSFALGLLR------LGATVVV-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 289 LPKFDPQTVLKVLSSYPINSL-VGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAK-TGLYIREFYGQTE 366
Cdd:cd05904 233 MPRFDLEELLAAIERYKVTHLpVVPPIVLALVKSPIVDKYDLSSLRQIMSGAAPLGKELIEAFRAKfPNVDLGQGYGMTE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 367 TglTCRISRT-----MTVKPGSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRG 440
Cdd:cd05904 313 S--TGVVAMCfapekDRAKYGSVGRLVPNVEAKIVDpETGESLPPNQTGELWIR-GP----SIMKGYLNNPEATAATIDK 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 441 DFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAP 519
Cdd:cd05904 386 EGWLhTGDLCYIDEDGYLFIVDRLKELIKYKG-----FQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMAFVVRKP 460
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 520 E-FLShdPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd05904 461 GsSLT--EDEIMDFVAKQV----APYKKVRKVAFVDAIPKSPSGKILRKEL 505
|
|
| DltA |
cd05945 |
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ... |
60-569 |
3.72e-45 |
|
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 165.88 E-value: 3.72e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiq 139
Cdd:cd05945 1 AAANPDRPAVVE-----GGRTLTYRELKERADALAAALAS-LGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVP---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 mkstdilyrlqsskARAIVAGDEVAQEVDAVAPDcsflkikLLVSDNrregwlnfktllkdvsnthhcvetgsHEPAAIY 219
Cdd:cd05945 71 --------------LDASSPAERIREILDAAKPA-------LLIADG--------------------------DDNAYII 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 220 FTSGTSGLPKMAEHSHSSLglkakmdadswtglnVSDTVWTISDTG------WIVNILTSF------LEP-WTLGACVFV 286
Cdd:cd05945 104 FTSGSTGRPKGVQISHDNL---------------VSFTNWMLSDFPlgpgdvFLNQAPFSFdlsvmdLYPaLASGATLVP 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 ylLPK---FDPQTVLKVLSSYPINSLVGAPLIYRMLLQ-QDLSRYKFPHLHSCYTGGESLLPETLENWKAKT-GLYIREF 361
Cdd:cd05945 169 --VPRdatADPKQLFRFLAEHGITVWVSTPSFAAMCLLsPTFTPESLPSLRHFLFCGEVLPHKTARALQQRFpDARIYNT 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETGLTC---RISRTMTVKPGSL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPKKT 434
Cdd:cd05945 247 YGPTEATVAVtyiEVTPEVLDGYDRLpiGYAKPGAKLVILDEDGRPVPPGEKGELVIS-------GpsVSKGYLNNPEKT 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 -EANIRGDFWLL---GDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:cd05945 320 aAAFFPDEGQRAyrtGDLVRLEADGLLFYRGRLDFQVKLNG-----YRIELEEIEAALRQVPGVKEAVVVPKYKGEKVTE 394
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 511 VKAFVVLAPeflsHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd05945 395 LIAFVVPKP----GAEAGLTKAIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
|
|
| PRK07470 |
PRK07470 |
acyl-CoA synthetase; Validated |
57-572 |
3.78e-44 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 164.44 E-value: 3.78e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 57 MEKAGKR-PPRPALWWmngsGEElKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMP 135
Cdd:PRK07470 13 LRQAARRfPDRIALVW----GDR-SWTWREIDARVDALAAALAAR-GVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 136 GTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREgwLNFKTLLKDVSNTHHCVETGSHE- 214
Cdd:PRK07470 87 TNFRQTPDEVAYLAEASGARAMICHADFPEHAAAVRAASPDLTHVVAIGGARAG--LDYEALVARHLGARVANAAVDHDd 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHSSLG-LKAKMDADSWTGLNVSDtvwtisdtgwiVNILTSflePWTLGACVF-------- 285
Cdd:PRK07470 165 PCWFFFTSGTTGRPKAAVLTHGQMAfVITNHLADLMPGTTEQD-----------ASLVVA---PLSHGAGIHqlcqvarg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 286 --VYLLP--KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHL-HSCYTGGesllPETLENWK---AKTGL 356
Cdd:PRK07470 231 aaTVLLPseRFDPAEVWALVERHRVTNLFTVPTILKMLVEHpAVDRYDHSSLrYVIYAGA----PMYRADQKralAKLGK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 357 YIREFYGQTE-TGltcrisrTMTVKP--------------GSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPfrpi 421
Cdd:PRK07470 307 VLVQYFGLGEvTG-------NITVLPpalhdaedgpdariGTCGFERTGMEVQIQDDEGRELPPGETGEICVIGPA---- 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 422 gIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVIS 501
Cdd:PRK07470 376 -VFAGYYNNPEANAKAFRDGWFRTGDLGHLDARGFLYITGRASDMYISGGSN-----VYPREIEEKLLTHPAVSEVAVLG 449
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 502 SPDPTRGEVVKAfVVLAPEFLSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PRK07470 450 VPDPVWGEVGVA-VCVARDGAPVDEAELLAWLDGKV----ARYKLPKRFFFWDALPKSGYGKITKKMVREE 515
|
|
| PRK13391 |
PRK13391 |
acyl-CoA synthetase; Provisional |
60-575 |
9.82e-44 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 162.94 E-value: 9.82e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWwMNGSGEELkwNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK13391 7 AQTTPDKPAVI-MASTGEVV--TYRELDERSNRLAHLFRS-LGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLV-SDNRREGWLNFKTLLKDVSNTHHCVETgshEPAAI 218
Cdd:PRK13391 83 LTPAEAAYIVDDSGARALITSAAKLDVARALLKQCPGVRHRLVLdGDGELEGFVGYAEAVAGLPATPIADES---LGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 219 YFTSGTSGLPKmaehshsslGLKAKM-DADSWTGLNVSD---TVWTISDTgwivnilTSFLEP----------WT----- 279
Cdd:PRK13391 160 LYSSGTTGRPK---------GIKRPLpEQPPDTPLPLTAflqRLWGFRSD-------MVYLSPaplyhsapqrAVmlvir 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 280 LGACVFVylLPKFDPQTVLKVLSSYPINSLVGAPLIY-RML-LQQDL-SRYKFPHLHSCYTGGESLLPETLENWKAKTGL 356
Cdd:PRK13391 224 LGGTVIV--MEHFDAEQYLALIEEYGVTHTQLVPTMFsRMLkLPEEVrDKYDLSSLEVAIHAAAPCPPQVKEQMIDWWGP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 357 YIREFYGQTETGLTCRI-SRTMTVKPGSLGTAVPHyDVQVIDEQGNVLPPGKEGDIAIRV-KPFRpigifsgYVDNPKKT 434
Cdd:PRK13391 302 IIHEYYAATEGLGFTACdSEEWLAHPGTVGRAMFG-DLHILDDDGAELPPGEPGTIWFEGgRPFE-------YLNDPAKT 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 EA--NIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVK 512
Cdd:PRK13391 374 AEarHPDGTWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVN-----IYPQEAENLLITHPKVADAAVFGVPNEDLGEEVK 448
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 513 AFVVLAPeflSHDPD-----QLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWK 575
Cdd:PRK13391 449 AVVQPVD---GVDPGpalaaELIAFCRQRL----SRQKCPRSIDFEDELPRLPTGKLYKRLLRDRYWG 509
|
|
| PRK03640 |
PRK03640 |
o-succinylbenzoate--CoA ligase; |
57-573 |
1.02e-43 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 162.44 E-value: 1.02e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 57 MEKAGKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTG--LVFM 134
Cdd:PRK03640 9 KQRAFLTPDRTAI-----EFEEKKVTFMELHEAVVSVAGKLAA-LGVKKGDRVALLMKNGMEMILVIHALQQLGavAVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 135 PGTIQMKstDILYRLQSSKARAIVAGDEVAQEVdavapdcsFLKIKLLVSDnRREGWLNFKTLLKDVSNThhcvetgshE 214
Cdd:PRK03640 83 NTRLSRE--ELLWQLDDAEVKCLITDDDFEAKL--------IPGISVKFAE-LMNGPKEEAEIQEEFDLD---------E 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPK-----MAEHSHSS------LGLKAKmdaDSW---------TGLNVsdtvwtisdtgwivnILTSF 274
Cdd:PRK03640 143 VATIMYTSGTTGKPKgviqtYGNHWWSAvgsalnLGLTED---DCWlaavpifhiSGLSI---------------LMRSV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 275 LEPWTlgacvfVYLLPKFDPQTVLKVLSSYPIN--SLVGApliyrmLLQQDLSRYKFPHLHSCYT-----GGESLLPeTL 347
Cdd:PRK03640 205 IYGMR------VVLVEKFDAEKINKLLQTGGVTiiSVVST------MLQRLLERLGEGTYPSSFRcmllgGGPAPKP-LL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 348 ENWKAKtGLYIREFYGQTETGltcriSRTMTVKP-------GSLGTavPHYDVQV-IDEQGNVLPPGKEGDIAIRvKPfr 419
Cdd:PRK03640 272 EQCKEK-GIPVYQSYGMTETA-----SQIVTLSPedaltklGSAGK--PLFPCELkIEKDGVVVPPFEEGEIVVK-GP-- 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 420 piGIFSGYVDNPKKTEANIRgDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETV 498
Cdd:PRK03640 341 --NVTKGYLNREDATRETFQ-DGWFkTGDIGYLDEEGFLYVLDRRSDLIISGGEN-----IYPAEIEEVLLSHPGVAEAG 412
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 499 VISSPDPTRGEVVKAFVVLAPEFlshDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK03640 413 VVGVPDDKWGQVPVAFVVKSGEV---TEEELRHFCEEKL----AKYKVPKRFYFVEELPRNASGKLLRHELKQLV 480
|
|
| PRK09088 |
PRK09088 |
acyl-CoA synthetase; Validated |
79-570 |
1.14e-43 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 162.67 E-value: 1.14e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 79 LKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVL-SQVpewWLVTL--GCIRTGLVFMPGTIQMKSTDILYRLQSSKAR 155
Cdd:PRK09088 21 RRWTYAELDALVGRLAAVLRRR-GCVDGERLAVLArNSV---WLVALhfACARVGAIYVPLNWRLSASELDALLQDAEPR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 156 AIVAGDEVAQ-EVDAVAPDCSFLKIKLLVSDNRREgwlnfktllkdvsnthhcveTGSHEPAAIYFTSGTSGLPKMA--- 231
Cdd:PRK09088 97 LLLGDDAVAAgRTDVEDLAAFIASADALEPADTPS--------------------IPPERVSLILFTSGTSGQPKGVmls 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 232 ----EHSHSSLGLKAKMDADSwtglnvsdtVWTISDTGW-IVNILTSFLEPWTLGACVFVYllPKFDPQTVLKVLS--SY 304
Cdd:PRK09088 157 ernlQQTAHNFGVLGRVDAHS---------SFLCDAPMFhIIGLITSVRPVLAVGGSILVS--NGFEPKRTLGRLGdpAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 305 PINSLVGAPLIYRMLLQQ---DLSRYKfpHLHSCYTGGESLLPETLENWKAKtGLYIREFYGQTETGLTCRISRTMTV-- 379
Cdd:PRK09088 226 GITHYFCVPQMAQAFRAQpgfDAAALR--HLTALFTGGAPHAAEDILGWLDD-GIPMVDGFGMSEAGTVFGMSVDCDVir 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 380 -KPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYF 457
Cdd:PRK09088 303 aKAGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGP-----NLSPGYWRRPQATARAFTGDGWFrTGDIARRDADGFF 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 458 HFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEflshDPDQLTKLLqQHV 537
Cdd:PRK09088 378 WVVDRKKDMFISGGEN-----VYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAIVPADG----APLDLERIR-SHL 447
|
490 500 510
....*....|....*....|....*....|...
gi 2025697431 538 KSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK09088 448 STRLAKYKVPKHLRLVDALPRTASGKLQKARLR 480
|
|
| VL_LC_FACS_like |
cd05907 |
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ... |
76-569 |
4.29e-43 |
|
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 160.07 E-value: 4.29e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 76 GEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiqMKSTD----ILYRLQS 151
Cdd:cd05907 1 GVWQPITWAEFAEEVRALAKGLIA-LGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVP----IYPTSsaeqIAYILND 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 152 SKARAIVAGDevaqevdavaPDcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshEPAAIYFTSGTSGLPKMA 231
Cdd:cd05907 76 SEAKALFVED----------PD----------------------------------------DLATIIYTSGTTGRPKGV 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 232 EHSHSSLglkakmdadSWTGLNVSDTvWTISDTGWIVNIL---------TSFLEPWTLGACVfvYLLPkfDPQTVLKVLS 302
Cdd:cd05907 106 MLSHRNI---------LSNALALAER-LPATEGDRHLSFLplahvferrAGLYVPLLAGARI--YFAS--SAETLLDDLS 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 303 SYPINSLVGAPLIYRML----LQQDLSRYK--------FPHLHSCYTGGESLLPETLEnWKAKTGLYIREFYGQTETGLT 370
Cdd:cd05907 172 EVRPTVFLAVPRVWEKVyaaiKVKAVPGLKrklfdlavGGRLRFAASGGAPLPAELLH-FFRALGIPVYEGYGLTETSAV 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 371 CRISRTMTVKPGSLGTAVPHYDVQvIDEQGNVLppgkegdiairvkpFRPIGIFSGYVDNPKKTEANIRGDFWL-LGDRG 449
Cdd:cd05907 251 VTLNPPGDNRIGTVGKPLPGVEVR-IADDGEIL--------------VRGPNVMLGYYKNPEATAEALDADGWLhTGDLG 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 450 TKDPEGYFHFIGRTDDIINssgTSFCRYrIGPSEVENALMEHPAVAETVVISSPDPtrgeVVKAFVVLAPEFLSH----- 524
Cdd:cd05907 316 EIDEDGFLHITGRKKDLII---TSGGKN-ISPEPIENALKASPLISQAVVIGDGRP----FLVALIVPDPEALEAwaeeh 387
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2025697431 525 ------------DPDQLtKLLQQHVKSVTA---PYKYPRKVeFVLDLPKTI-------TGKIERAKL 569
Cdd:cd05907 388 giaytdvaelaaNPAVR-AEIEAAVEAANArlsRYEQIKKF-LLLPEPFTIengeltpTLKLKRPVI 452
|
|
| AA-adenyl-dom |
TIGR01733 |
amino acid adenylation domain; This model represents a domain responsible for the specific ... |
84-499 |
7.62e-43 |
|
amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.
Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 158.20 E-value: 7.62e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 84 RELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiqmksTDILY---RLQS----SKARA 156
Cdd:TIGR01733 3 RELDERANRLARHLRAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVP-------LDPAYpaeRLAFiledAGARL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 157 IVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRRegwlnfktllkdVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHS 236
Cdd:TIGR01733 76 LLTDSALASRLAGLVLPVILLDPLELAALDDA------------PAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 237 SL--------GLKAKMDADSWtgLNVSDTVWTISdtgwivniLTSFLEPWTLGACVFVYL--LPKFDPQTVLKVLSSYPI 306
Cdd:TIGR01733 144 SLvnllawlaRRYGLDPDDRV--LQFASLSFDAS--------VEEIFGALLAGATLVVPPedEERDDAALLAALIAEHPV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 307 NSLVGAPLIYRMLLQQDLSRykFPHLHSCYTGGESLLPETLENWKAKTG-LYIREFYGQTETGLTC---RISRTMTVKPG 382
Cdd:TIGR01733 214 TVLNLTPSLLALLAAALPPA--LASLRLVILGGEALTPALVDRWRARGPgARLINLYGPTETTVWStatLVDPDDAPRES 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 383 SL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIrvkpfRPIGIFSGYVDNPKKT-EANIRGDFWLL--------GDRGTK 451
Cdd:TIGR01733 292 PVpiGRPLANTRLYVLDDDLRPVPVGVVGELYI-----GGPGVARGYLNRPELTaERFVPDPFAGGdgarlyrtGDLVRY 366
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2025697431 452 DPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVV 499
Cdd:TIGR01733 367 LPDGNLEFLGRIDDQVKIRG-----YRIELGEIEAALLRHPGVREAVV 409
|
|
| PRK07059 |
PRK07059 |
Long-chain-fatty-acid--CoA ligase; Validated |
83-570 |
1.07e-42 |
|
Long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 160.96 E-value: 1.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMpgtiqmkSTDILY-------RLQSSKAR 155
Cdd:PRK07059 51 YGELDELSRALAAWLQSR-GLAKGARVAIMMPNVLQYPVAIAAVLRAGYVVV-------NVNPLYtprelehQLKDSGAE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 156 AIVAGDEVAQEVDAVAPDCS---------------------FL--KIKLLVSDNRREGWLNFKTLLKDVSN-THHCVETG 211
Cdd:PRK07059 123 AIVVLENFATTVQQVLAKTAvkhvvvasmgdllgfkghivnFVvrRVKKMVPAWSLPGHVRFNDALAEGARqTFKPVKLG 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 212 SHEPAAIYFTSGTSGLPKMAEHSHSSLgLKAKMDADSWtgLNVSDTVWTISDTGWIVNIL---------TSFLEPWTLGA 282
Cdd:PRK07059 203 PDDVAFLQYTGGTTGVSKGATLLHRNI-VANVLQMEAW--LQPAFEKKPRPDQLNFVCALplyhifaltVCGLLGMRTGG 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVFVYLLPKfDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREF 361
Cdd:PRK07059 280 RNILIPNPR-DIPGFIKELKKYQVHIFPAVNTLYNALLNNpDFDKLDFSKLIVANGGGMAVQRPVAERWLEMTGCPITEG 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETG--LTCRiSRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPKKTEAN 437
Cdd:PRK07059 359 YGLSETSpvATCN-PVDATEFSGTIGLPLPSTEVSIRDDDGNDLPLGEPGEICIR-------GpqVMAGYWNRPDETAKV 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGD-FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsFCRYrigPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVV 516
Cdd:PRK07059 431 MTADgFFRTGDVGVMDERGYTKIVDRKKDMILVSG--FNVY---PNEIEEVVASHPGVLEVAAVGVPDEHSGEAVKLFVV 505
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 517 lapeflSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK07059 506 ------KKDPALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRRELR 553
|
|
| PRK08974 |
PRK08974 |
long-chain-fatty-acid--CoA ligase FadD; |
39-573 |
1.39e-42 |
|
long-chain-fatty-acid--CoA ligase FadD;
Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 160.60 E-value: 1.39e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 39 EIPAKFNfandvVDHWANM----EKAGKR-PPRPALWWMngsGEELkwNFRELSEISQRAANVLSGPCGLQRGDRVAVVL 113
Cdd:PRK08974 12 DVPAEIN-----PDRYQSLvdmfEQAVARyADQPAFINM---GEVM--TFRKLEERSRAFAAYLQNGLGLKKGDRVALMM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 114 SQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDC--------------SFLK- 178
Cdd:PRK08974 82 PNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTpvkhviltrmgdqlSTAKg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 179 ---------IKLLVSDNRREGWLNFKTLLK----------DVSNThhcvetgshEPAAIYFTSGTSGLPKMAEHSHSSLg 239
Cdd:PRK08974 162 tlvnfvvkyIKRLVPKYHLPDAISFRSALHkgrrmqyvkpELVPE---------DLAFLQYTGGTTGVAKGAMLTHRNM- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 240 LKAKMDADSWTG--LNVSDTVWTISDTGWIVNILTS----FLEpwtLGACVFVYLLPKFDPQTVlKVLSSYPINSLVGAP 313
Cdd:PRK08974 232 LANLEQAKAAYGplLHPGKELVVTALPLYHIFALTVncllFIE---LGGQNLLITNPRDIPGFV-KELKKYPFTAITGVN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 314 LIYRMLLQ-QDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTEtgltCriSRTMTVKP-------GSLG 385
Cdd:PRK08974 308 TLFNALLNnEEFQELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTE----C--SPLVSVNPydldyysGSIG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 386 TAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPKKTeANIRGDFWL-LGDRGTKDPEGYFHFIGR 462
Cdd:PRK08974 382 LPVPSTEIKLVDDDGNEVPPGEPGELWVK-------GpqVMLGYWQRPEAT-DEVIKDGWLaTGDIAVMDEEGFLRIVDR 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 463 TDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDPdqltklLQQHVKSVTA 542
Cdd:PRK08974 454 KKDMILVSG-----FNVYPNEIEDVVMLHPKVLEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEE------LITHCRRHLT 522
|
570 580 590
....*....|....*....|....*....|.
gi 2025697431 543 PYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK08974 523 GYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
|
|
| OSB_CoA_lg |
cd05912 |
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ... |
80-571 |
1.51e-42 |
|
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.
Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 157.51 E-value: 1.51e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLsGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKaraiVA 159
Cdd:cd05912 1 SYTFAELFEEVSRLAEHL-AALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSD----VK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 160 GDEVAqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshepaAIYFTSGTSGLPKMAE-----HS 234
Cdd:cd05912 76 LDDIA----------------------------------------------------TIMYTSGTTGKPKGVQqtfgnHW 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 235 HSSLGLKAKM---DADSW---------TGLNVsdtvwtisdtgwivnILTSFLEPWTlgacvfVYLLPKFDPQTVLKVLS 302
Cdd:cd05912 104 WSAIGSALNLgltEDDNWlcalplfhiSGLSI---------------LMRSVIYGMT------VYLVDKFDAEQVLHLIN 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 303 SYPIN--SLVgaPLIYRMLLQQDLSRYKfPHLHSCYTGGESLLPETLENWKAKtGLYIREFYGQTETgltCRISRTMT-- 378
Cdd:cd05912 163 SGKVTiiSVV--PTMLQRLLEILGEGYP-NNLRCILLGGGPAPKPLLEQCKEK-GIPVYQSYGMTET---CSQIVTLSpe 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 379 ---VKPGSLGTAVPHYDVQVIDEQGnvlPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEG 455
Cdd:cd05912 236 dalNKIGSAGKPLFPVELKIEDDGQ---PPYEVGEILLK-GP----NVTKGYLNRPDATEESFENGWFKTGDIGYLDEEG 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 456 YFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlshDPDQLTKLLQQ 535
Cdd:cd05912 308 FLYVLDRRSDLIISGGEN-----IYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSERPI---SEEELIAYCSE 379
|
490 500 510
....*....|....*....|....*....|....*.
gi 2025697431 536 HVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05912 380 KL----AKYKVPKKIYFVDELPRTASGKLLRHELKQ 411
|
|
| PRK05677 |
PRK05677 |
long-chain-fatty-acid--CoA ligase; Validated |
83-579 |
1.72e-42 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 160.70 E-value: 1.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDE 162
Cdd:PRK05677 52 YGELYKLSGAFAAWLQQHTDLKPGDRIAVQLPNVLQYPVAVFGAMRAGLIVVNTNPLYTAREMEHQFNDSGAKALVCLAN 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 VAQEVDAVAPDC--------------SFLK----------IKLLVSDNRREGWLNFKTLL-KDVSNTHHCVETGSHEPAA 217
Cdd:PRK05677 132 MAHLAEKVLPKTgvkhvivtevadmlPPLKrllinavvkhVKKMVPAYHLPQAVKFNDALaKGAGQPVTEANPQADDVAV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPKMAEHSHSSL-----GLKAKMdadswtGLNVSDTVWTIsdtgwIVNILTSFLEPWTLGaCVFVYLL--- 289
Cdd:PRK05677 212 LQYTGGTTGVAKGAMLTHRNLvanmlQCRALM------GSNLNEGCEIL-----IAPLPLYHIYAFTFH-CMAMMLIgnh 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 ------PKfDPQTVLKVLSSYPINSLVGAPLIYRMLLQ-QDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFY 362
Cdd:PRK05677 280 nilisnPR-DLPAMVKELGKWKFSGFVGLNTLFVALCNnEAFRKLDFSALKLTLSGGMALQLATAERWKEVTGCAICEGY 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDF 442
Cdd:PRK05677 359 GMTETSPVVSVNPSQAIQVGTIGIPVPSTLCKVIDDDGNELPLGEVGELCVK-GP----QVMKGYWQRPEATDEILDSDG 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 443 WL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEf 521
Cdd:PRK05677 434 WLkTGDIALIQEDGYMRIVDRKKDMILVSG-----FNVYPNELEDVLAALPGVLQCAAIGVPDEKSGEAIKVFVVVKPG- 507
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 522 lshdpDQLTK-LLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSGQ 579
Cdd:PRK05677 508 -----ETLTKeQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRRELRDEELKKAGL 561
|
|
| PRK08751 |
PRK08751 |
long-chain fatty acid--CoA ligase; |
83-570 |
1.92e-42 |
|
long-chain fatty acid--CoA ligase;
Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 160.43 E-value: 1.92e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDE 162
Cdd:PRK08751 53 YREADQLVEQFAAYLLGELQLKKGDRVALMMPNCLQYPIATFGVLRAGLTVVNVNPLYTPRELKHQLIDSGASVLVVIDN 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 VAQEVDAVAPDC--------------SFLK----------IKLLVSDNRREGWLNFKTLLKdvSNTHHCVETGSHEPAAI 218
Cdd:PRK08751 133 FGTTVQQVIADTpvkqvittglgdmlGFPKaalvnfvvkyVKKLVPEYRINGAIRFREALA--LGRKHSMPTLQIEPDDI 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 219 YF---TSGTSGLPKMAEHSHSSlgLKAKM-DADSWTGLNVS-----DTVWTISDTGWIVNILTSFLEPWTLGACVFVYLL 289
Cdd:PRK08751 211 AFlqyTGGTTGVAKGAMLTHRN--LVANMqQAHQWLAGTGKleegcEVVITALPLYHIFALTANGLVFMKIGGCNHLISN 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKfDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETG 368
Cdd:PRK08751 289 PR-DMPGFVKELKKTRFTAFTGVNTLFNGLLNTpGFDQIDFSSLKMTLGGGMAVQRSVAERWKQVTGLTLVEAYGLTETS 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 369 -LTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPfrpigIFSGYVDNPKKTEANIRGDFWL-LG 446
Cdd:PRK08751 368 pAACINPLTLKEYNGSIGLPIPSTDACIKDDAGTVLAIGEIGELCIKGPQ-----VMKGYWKRPEETAKVMDADGWLhTG 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVlapeflSHDP 526
Cdd:PRK08751 443 DIARMDEQGFVYIVDRKKDMILVSG-----FNVYPNEIEDVIAMMPGVLEVAAVGVPDEKSGEIVKVVIV------KKDP 511
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2025697431 527 DQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK08751 512 ALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELR 555
|
|
| PRK13295 |
PRK13295 |
cyclohexanecarboxylate-CoA ligase; Reviewed |
60-570 |
7.42e-42 |
|
cyclohexanecarboxylate-CoA ligase; Reviewed
Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 158.68 E-value: 7.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWMN-GSGEELKWNFRELSEISQRAANVLSgPCGLQRGDrvaVVLSQVPEWWLVT---LGCIRTGLVFMP 135
Cdd:PRK13295 34 VASCPDKTAVTAVRlGTGAPRRFTYRELAALVDRVAVGLA-RLGVGRGD---VVSCQLPNWWEFTvlyLACSRIGAVLNP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 136 GTIQMKSTDILYRLQSSKARAIVA-----GDEVAQEVDAVAPDCSFLKiKLLVSDNrrEGWLNFKTLL--------KDVS 202
Cdd:PRK13295 110 LMPIFRERELSFMLKHAESKVLVVpktfrGFDHAAMARRLRPELPALR-HVVVVGG--DGADSFEALLitpaweqePDAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 203 NTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSL-----GLKAKMdadswtGLNVSDTVWTISDTGWIVNILTSFLEP 277
Cdd:PRK13295 187 AILARLRPGPDDVTQLIYTSGTTGEPKGVMHTANTLmanivPYAERL------GLGADDVILMASPMAHQTGFMYGLMMP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 278 WTLGACVFvyLLPKFDPQTVLKVLSSYPIN-SLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGL 356
Cdd:PRK13295 261 VMLGATAV--LQDIWDPARAAELIRTEGVTfTMASTPFLTDLTRAVKESGRPVSSLRTFLCAGAPIPGALVERARAALGA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 357 YIREFYGQTETGL--TCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKT 434
Cdd:PRK13295 339 KIVSAWGMTENGAvtLTKLDDPDERASTTDGCPLPGVEVRVVDADGAPLPAGQIGRLQVR-----GCSNFGGYLKRPQLN 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 EANIRGdfWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKA 513
Cdd:PRK13295 414 GTDADG--WFdTGDLARIDADGYIRISGRSKDVIIRGGEN-----IPVVEIEALLYRHPAIAQVAIVAYPDERLGERACA 486
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 2025697431 514 FVVLAPEfLSHDPDQLTKLLQQHvkSVTAPYkYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK13295 487 FVVPRPG-QSLDFEEMVEFLKAQ--KVAKQY-IPERLVVRDALPRTPSGKIQKFRLR 539
|
|
| PRK07788 |
PRK07788 |
acyl-CoA synthetase; Validated |
83-573 |
8.46e-41 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 155.47 E-value: 8.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPcGLQRGDRVAVvLSQVPEWWLVTL-GCIRTGL-VFMPGT----IQMKstDILYRLqssKARA 156
Cdd:PRK07788 77 YAELDEQSNALARGLLAL-GVRAGDGVAV-LARNHRGFVLALyAAGKVGArIILLNTgfsgPQLA--EVAARE---GVKA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 157 IVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLlKDVsnthhcVETGSHEPAA--------IYFTSGTSGLP 228
Cdd:PRK07788 150 LVYDDEFTDLLSALPPDLGRLRAWGGNPDDDEPSGSTDETL-DDL------IAGSSTAPLPkppkpggiVILTSGTTGTP 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 229 KMAEHSH-SSLGLKAKM-DADSW-TGLNVSDTVWTISDTGWIVNILTsflepWTLGACVFvyLLPKFDPQTVLKVLSSYP 305
Cdd:PRK07788 223 KGAPRPEpSPLAPLAGLlSRVPFrAGETTLLPAPMFHATGWAHLTLA-----MALGSTVV--LRRRFDPEATLEDIAKHK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 306 INSLVGAP-LIYRML--LQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLtCRISR--TMTVK 380
Cdd:PRK07788 296 ATALVVVPvMLSRILdlGPEVLAKYDTSSLKIIFVSGSALSPELATRALEAFGPVLYNLYGSTEVAF-ATIATpeDLAEA 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 381 PGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVkpfrpiGI-FSGYVDNPKKTEanIRGdfwLL--GDRGTKDPEGYF 457
Cdd:PRK07788 375 PGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGN------GFpFEGYTDGRDKQI--IDG---LLssGDVGYFDEDGLL 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 458 HFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQltklLQQHV 537
Cdd:PRK07788 444 FVDGRDDDMIVSGGEN-----VFPAEVEDLLAGHPDVVEAAVIGVDDEEFGQRLRAFVVKAPG-AALDEDA----IKDYV 513
|
490 500 510
....*....|....*....|....*....|....*.
gi 2025697431 538 KSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK07788 514 RDNLARYKVPRDVVFLDELPRNPTGKVLKRELREMD 549
|
|
| PRK06145 |
PRK06145 |
acyl-CoA synthetase; Validated |
60-572 |
1.60e-40 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 153.89 E-value: 1.60e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWmngSGEELkwNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK06145 12 ARRTPDRAALVY---RDQEI--SYAEFHQRILQAAGMLHAR-GIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPdcsflKIKL---LVSDNRREGwlnfktllkdvSNTHHCVETGSHEPA 216
Cdd:PRK06145 86 LAADEVAYILGDAGAKLLLVDEEFDAIVALETP-----KIVIdaaAQADSRRLA-----------QGGLEIPPQAAVAPT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 217 AIY---FTSGTSGLPKMAEHSHSSLGLKAkMDADSWTGLNVSDTVWTIsdtGWIVNI----LTSFLEPWTLGacvFVYLL 289
Cdd:PRK06145 150 DLVrlmYTSGTTDRPKGVMHSYGNLHWKS-IDHVIALGLTASERLLVV---GPLYHVgafdLPGIAVLWVGG---TLRIH 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKFDPQTVLKVLSSYPINSLVGAP-LIYRMLLQQDLSRYKFPHLHSCYTGGESLlPEtlenwkaktgLYIREF------- 361
Cdd:PRK06145 223 REFDPEAVLAAIERHRLTCAWMAPvMLSRVLTVPDRDRFDLDSLAWCIGGGEKT-PE----------SRIRDFtrvftra 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 -----YGQTET--GLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKT 434
Cdd:PRK06145 292 ryidaYGLTETcsGDTLMEAGREIEKIGSTGRALAHVEIRIADGAGRWLPPNMKGEICMR-GP----KVTKGYWKDPEKT 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 EANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAF 514
Cdd:PRK06145 367 AEAFYGDWFRSGDVGYLDEEGFLYLTDRKKDMIISGGEN-----IASSEVERVIYELPEVAEAAVIGVHDDRWGERITAV 441
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 515 VVLAP-EFLSHDPdqltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PRK06145 442 VVLNPgATLTLEA------LDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDE 494
|
|
| PRK08315 |
PRK08315 |
AMP-binding domain protein; Validated |
79-570 |
2.79e-40 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 154.20 E-value: 2.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 79 LKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMpgTIQ--MKSTDILYRLQSSKARA 156
Cdd:PRK08315 42 LRWTYREFNEEVDALAKGLLA-LGIEKGDRVGIWAPNVPEWVLTQFATAKIGAILV--TINpaYRLSELEYALNQSGCKA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 157 IVAGDEV-----AQEVDAVAPDCS-------------FLKIKLLVSDNRREGWLNFKTLLKDVSNTH-----------HC 207
Cdd:PRK08315 119 LIAADGFkdsdyVAMLYELAPELAtcepgqlqsarlpELRRVIFLGDEKHPGMLNFDELLALGRAVDdaelaarqatlDP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 208 vetgsHEPAAIYFTSGTSGLPKMAEHSHSSLGLkakmdadswTGLNVSDTV-WTISDT-----------GWIVNILTSFl 275
Cdd:PRK08315 199 -----DDPINIQYTSGTTGFPKGATLTHRNILN---------NGYFIGEAMkLTEEDRlcipvplyhcfGMVLGNLACV- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 276 epwTLGACVfVYLLPKFDPQTVLKVLSSYPINSLVGAPLIY-RMLLQQDLSRYKFPHLHscyTG---GeSLLP-ETLEnw 350
Cdd:PRK08315 264 ---THGATM-VYPGEGFDPLATLAAVEEERCTALYGVPTMFiAELDHPDFARFDLSSLR---TGimaG-SPCPiEVMK-- 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 351 KAKTGLYIREF---YGQTETG---LTCRIS-----RTMTVkpgslGTAVPHYDVQVID-EQGNVLPPGKEGDIAIRvkpf 418
Cdd:PRK08315 334 RVIDKMHMSEVtiaYGMTETSpvsTQTRTDdplekRVTTV-----GRALPHLEVKIVDpETGETVPRGEQGELCTR---- 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 419 rpiG--IFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVA 495
Cdd:PRK08315 405 ---GysVMKGYWNDPEKTAEAIDADGWMhTGDLAVMDEEGYVNIVGRIKDMIIRGGEN-----IYPREIEEFLYTHPKIQ 476
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 496 ETVVISSPDPTRGEVVKAFVVLapeflsHDPDQLTKL-LQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK08315 477 DVQVVGVPDEKYGEEVCAWIIL------RPGATLTEEdVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMR 546
|
|
| 23DHB-AMP_lg |
cd05920 |
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ... |
58-569 |
5.04e-40 |
|
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.
Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 152.10 E-value: 5.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLV---FM 134
Cdd:cd05920 23 RSAARHPDRIAV-----VDGDRRLTYRELDRRADRLAAGLRG-LGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVpvlAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 135 PGtiqMKSTDILYRLQSSKARAIVAGDEvAQEVDAVApdcsflkikllvsdnrregwlNFKTLLKDVSnthhcvetgshE 214
Cdd:cd05920 97 PS---HRRSELSAFCAHAEAVAYIVPDR-HAGFDHRA---------------------LARELAESIP-----------E 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADsWTGLNvSDTVW----------TISDTGwivnILTSFLepwtLGACV 284
Cdd:cd05920 141 VALFLLSGGTTGTPKLIPRTHNDYAYNVRASAE-VCGLD-QDTVYlavlpaahnfPLACPG----VLGTLL----AGGRV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 285 FvyLLPKFDPQTVLKVLSSYPIN--SLVgAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFY 362
Cdd:cd05920 211 V--LAPDPSPDAAFPLIEREGVTvtALV-PALVSLWLDAAASRRADLSSLRLLQVGGARLSPALARRVPPVLGCTLQQVF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTEtGLTC--RISRTMTVKPGSLGTAV-PHYDVQVIDEQGNVLPPGKEGDIAIRvKPFrpigIFSGYVDNPkktEANIR 439
Cdd:cd05920 288 GMAE-GLLNytRLDDPDEVIIHTQGRPMsPDDEIRVVDEEGNPVPPGEEGELLTR-GPY----TIRGYYRAP---EHNAR 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 G----DFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFV 515
Cdd:cd05920 359 AftpdGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGE-----KIAAEEVENLLLRHPAVHDAAVVAMPDELLGERSCAFV 433
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 516 VLAPEFLShdpdqlTKLLQQHVKSV-TAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd05920 434 VLRDPPPS------AAQLRRFLRERgLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482
|
|
| PRK00174 |
PRK00174 |
acetyl-CoA synthetase; Provisional |
83-571 |
6.23e-40 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 154.14 E-value: 6.23e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLV-------FMPGTIQMkstdilyRLQSSKAR 155
Cdd:PRK00174 101 YRELHREVCRFANALKS-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVhsvvfggFSAEALAD-------RIIDAGAK 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 156 AIVAGDE-------VA--QEVDAVAPDCSFLKiKLLVSdnRREG-----------WLNfkTLLKDVSNTHHCVETGSHEP 215
Cdd:PRK00174 173 LVITADEgvrggkpIPlkANVDEALANCPSVE-KVIVV--RRTGgdvdwvegrdlWWH--ELVAGASDECEPEPMDAEDP 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHS------HSSLGLKAKMDadswtgLNVSDTVWTISDTGWIvnilT--SFL--EPWTLGACVF 285
Cdd:PRK00174 248 LFILYTSGSTGKPKGVLHTtggylvYAAMTMKYVFD------YKDGDVYWCTADVGWV----TghSYIvyGPLANGATTL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 286 VYL-LPKF-DPQTVLKVLSSYPINSLVGAPLIYRMLLQQ--------DLSRYKFphLHSCytgGESLLPETLEnWkaktg 355
Cdd:PRK00174 318 MFEgVPNYpDPGRFWEVIDKHKVTIFYTAPTAIRALMKEgdehpkkyDLSSLRL--LGSV---GEPINPEAWE-W----- 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 356 lYIREFYG----------QTETG--LTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPF----R 419
Cdd:PRK00174 387 -YYKVVGGercpivdtwwQTETGgiMITPLPGATPLKPGSATRPLPGIQPAVVDEEGNPLEGGEGGNLVIK-DPWpgmmR 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 420 piGIFsG----YVDNPKKTEANIrgdfWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVA 495
Cdd:PRK00174 465 --TIY-GdherFVKTYFSTFKGM----YFTGDGARRDEDGYYWITGRVDDVLNVSG-----HRLGTAEIESALVAHPKVA 532
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 496 ETVVISSPDPTRGEVVKAFVVL----APEflshdpDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK00174 533 EAAVVGRPDDIKGQGIYAFVTLkggeEPS------DELRKELRNWVRKEIGPIAKPDVIQFAPGLPKTRSGKIMRRILRK 606
|
|
| FadD3 |
cd17638 |
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ... |
216-566 |
1.62e-39 |
|
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.
Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 147.26 E-value: 1.62e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPK--MAEHSHSSLGLKAKMDADSWTglnvSDTVWTISD---------TGWIVNILTsflepwtlGACV 284
Cdd:cd17638 3 SDIMFTSGTTGRSKgvMCAHRQTLRAAAAWADCADLT----EDDRYLIINpffhtfgykAGIVACLLT--------GATV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 285 fvylLPK--FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGL-YIRE 360
Cdd:cd17638 71 ----VPVavFDVDAILEAIERERITVLPGPPTLFQSLLDHpGRKKFDLSSLRAAVTGAATVPVELVRRMRSELGFeTVLT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 361 FYGQTETGLT--CRISRTMTVKPGSLGTAVPHYDVQVIDeQGNVLppgkegdiairvkpFRPIGIFSGYVDNPKKTEANI 438
Cdd:cd17638 147 AYGLTEAGVAtmCRPGDDAETVATTCGRACPGFEVRIAD-DGEVL--------------VRGYNVMQGYLDDPEATAEAI 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 439 RGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVL 517
Cdd:cd17638 212 DADGWLhTGDVGELDERGYLRITDRLKDMYIVGG-----FNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVA 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2025697431 518 APEfLSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIER 566
Cdd:cd17638 287 RPG-VTLTEEDVIAWCRERL----ANYKVPRFVRFLDELPRNASGKVMK 330
|
|
| FAA1 |
COG1022 |
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; |
60-572 |
1.67e-39 |
|
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 152.56 E-value: 1.67e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWMNGsGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtIQ 139
Cdd:COG1022 21 AARFPDRVALREKED-GIWQSLTWAEFAERVRALAAGLLA-LGVKPGDRVAILSDNRPEWVIADLAILAAGAVTVP--IY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKST--DILYRLQSSKARAIVAGD-EVAQEVDAVAPDCSFLKiKLLVSDNR----REGWLNFKTLLKDVSNTHH------ 206
Cdd:COG1022 97 PTSSaeEVAYILNDSGAKVLFVEDqEQLDKLLEVRDELPSLR-HIVVLDPRglrdDPRLLSLDELLALGREVADpaelea 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 207 -CVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLglkakmdadSWTGLNVsDTVWTISDTGWIVniltSFLePW------T 279
Cdd:COG1022 176 rRAAVKPDDLATIIYTSGTTGRPKGVMLTHRNL---------LSNARAL-LERLPLGPGDRTL----SFL-PLahvferT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 280 LGACVF-----VYLLPkfDPQTVLKVLSSYPINSLVGAPLIY------------------RMLLQQ--DLSR-------- 326
Cdd:COG1022 241 VSYYALaagatVAFAE--SPDTLAEDLREVKPTFMLAVPRVWekvyagiqakaeeagglkRKLFRWalAVGRryararla 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 327 -------YKFPH------------------LHSCYTGGESLLPETLENWKAkTGLYIREFYGQTETGLTCRISRTMTVKP 381
Cdd:COG1022 319 gkspsllLRLKHaladklvfsklrealggrLRFAVSGGAALGPELARFFRA-LGIPVLEGYGLTETSPVITVNRPGDNRI 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 382 GSLGTAVPhyDVQV-IDEQGNVLppgkegdiairVK-PfrpiGIFSGYVDNPKKTEANIRGDFWLL-GDRGTKDPEGYFH 458
Cdd:COG1022 398 GTVGPPLP--GVEVkIAEDGEIL-----------VRgP----NVMKGYYKNPEATAEAFDADGWLHtGDIGELDEDGFLR 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 459 FIGRTDDII-NSSGTsfcryRIGPSEVENALMEHPAVAETVVIsspdptrGE---VVKAFVVLAPEFLSH---------- 524
Cdd:COG1022 461 ITGRKKDLIvTSGGK-----NVAPQPIENALKASPLIEQAVVV-------GDgrpFLAALIVPDFEALGEwaeenglpyt 528
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2025697431 525 DPDQLTK------LLQQHVKSVTApyKYPRkVE----FVLdLPK---------TITGKIERAKLRAK 572
Cdd:COG1022 529 SYAELAQdpevraLIQEEVDRANA--GLSR-AEqikrFRL-LPKeftiengelTPTLKLKRKVILEK 591
|
|
| PRK12406 |
PRK12406 |
long-chain-fatty-acid--CoA ligase; Provisional |
84-578 |
3.59e-39 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 150.23 E-value: 3.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 84 RELSEISQRAANVLSG--PCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVA-G 160
Cdd:PRK12406 12 RSFDELAQRAARAAGGlaALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLIAhA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEVAQEVDAVAPDCSFLKI----KLL----VSDNRR---------EGWLNfktllkdvsnTHHCVETGSHE-PAAIYFTS 222
Cdd:PRK12406 92 DLLHGLASALPAGVTVLSVptppEIAaayrISPALLtppagaidwEGWLA----------QQEPYDGPPVPqPQSMIYTS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 223 GTSGLPKMAEHSHSSLGLKAKmdadswTGLNVSdTVWTISDTgwIVNILT---------SF-LEPWTLGACVFvyLLPKF 292
Cdd:PRK12406 162 GTTGHPKGVRRAAPTPEQAAA------AEQMRA-LIYGLKPG--IRALLTgplyhsapnAYgLRAGRLGGVLV--LQPRF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 293 DPQTVLKVLSSYPINSLVGAPLIYRMLLQ--------QDLSRYKFphlhscYTGGESLLP-----ETLENWkaktGLYIR 359
Cdd:PRK12406 231 DPEELLQLIERHRITHMHMVPTMFIRLLKlpeevrakYDVSSLRH------VIHAAAPCPadvkrAMIEWW----GPVIY 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTETGL-TCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVkpfRPIGIFSgYVDNPKKTEANI 438
Cdd:PRK12406 301 EYYGSTESGAvTFATSEDALSHPGTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRI---AGNPDFT-YHNKPEKRAEID 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 439 RGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLA 518
Cdd:PRK12406 377 RGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVN-----IYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEALMAVVEPQ 451
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 519 PEFlshDPDQLTklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG 578
Cdd:PRK12406 452 PGA---TLDEAD--IRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDPYWANAG 506
|
|
| PRK12492 |
PRK12492 |
long-chain-fatty-acid--CoA ligase; Provisional |
83-570 |
1.07e-38 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 149.59 E-value: 1.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDE 162
Cdd:PRK12492 52 YAELERHSAAFAAYLQQHTDLVPGDRIAVQMPNVLQYPIAVFGALRAGLIVVNTNPLYTAREMRHQFKDSGARALVYLNM 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 VAQEVDAVAPDCS--FL----------------------KIKLLVSDNRREGWLNFKTLLKD-VSNTHHCVETGSHEPAA 217
Cdd:PRK12492 132 FGKLVQEVLPDTGieYLieakmgdllpaakgwlvntvvdKVKKMVPAYHLPQAVPFKQALRQgRGLSLKPVPVGLDDIAV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPKMAEHSHSSL-----GLKAKMDADSWTGLnvsdTVWTISDTGWIVNILTSFLEPWTLGA-CVFV----- 286
Cdd:PRK12492 212 LQYTGGTTGLAKGAMLTHGNLvanmlQVRACLSQLGPDGQ----PLMKEGQEVMIAPLPLYHIYAFTANCmCMMVsgnhn 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 YLL--PKfDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYG 363
Cdd:PRK12492 288 VLItnPR-DIPGFIKELGKWRFSALLGLNTLFVALMDHpGFKDLDFSALKLTNSGGTALVKATAERWEQLTGCTIVEGYG 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 364 QTETG-LTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIRGDF 442
Cdd:PRK12492 367 LTETSpVASTNPYGELARLGTVGIPVPGTALKVIDDDGNELPLGERGELCIK-GP----QVMKGYWQQPEATAEALDAEG 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 443 WL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVlapef 521
Cdd:PRK12492 442 WFkTGDIAVIDPDGFVRIVDRKKDLIIVSG-----FNVYPNEIEDVVMAHPKVANCAAIGVPDERSGEAVKLFVV----- 511
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 2025697431 522 lSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK12492 512 -ARDPGLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELR 559
|
|
| PRK07798 |
PRK07798 |
acyl-CoA synthetase; Validated |
44-563 |
2.41e-38 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 148.11 E-value: 2.41e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 44 FNFAnDVVDHWANmekagKRPPRPALWWmngsGEElKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVT 123
Cdd:PRK07798 3 WNIA-DLFEAVAD-----AVPDRVALVC----GDR-RLTYAELEERANRLAHYLIAQ-GLGPGDHVGIYARNRIEYVEAM 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 124 LGCIRTGLVfmPGTIQMKSTD--ILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLLKDV 201
Cdd:PRK07798 71 LGAFKARAV--PVNVNYRYVEdeLRYLLDDSDAVALVYEREFAPRVAEVLPRLPKLRTLVVVEDGSGNDLLPGAVDYEDA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 202 snthhcVETGSHEPAA-------IYF--TSGTSGLPK--MAEHS---HSSLGlkakmDADSWTGlNVSDTVWTISDTG-- 265
Cdd:PRK07798 149 ------LAAGSPERDFgerspddLYLlyTGGTTGMPKgvMWRQEdifRVLLG-----GRDFATG-EPIEDEEELAKRAaa 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 266 -----WIV-----------NILTSFLEpwtlGACVFVYLLPKFDPQTVLKVLSSYPINSL--VG----APLI--YRMLLQ 321
Cdd:PRK07798 217 gpgmrRFPapplmhgagqwAAFAALFS----GQTVVLLPDVRFDADEVWRTIEREKVNVItiVGdamaRPLLdaLEARGP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 322 QDLSRykfphLHSCYTGGESLLPETLENW-KAKTGLYIREFYGQTETGLTcrisRTMTVKPGSLGTAVPHY----DVQVI 396
Cdd:PRK07798 293 YDLSS-----LFAIASGGALFSPSVKEALlELLPNVVLTDSIGSSETGFG----GSGTVAKGAVHTGGPRFtigpRTVVL 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 397 DEQGNVLPPG--KEGDIAIRvkPFRPIGifsgYVDNPKKTEAN---IRGDFW-LLGDRGTKDPEGYFHFIGRTDDIINSS 470
Cdd:PRK07798 364 DEDGNPVEPGsgEIGWIARR--GHIPLG----YYKDPEKTAETfptIDGVRYaIPGDRARVEADGTITLLGRGSVCINTG 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 471 GTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSHDPDQltklLQQHVKSVTAPYKYPRKV 550
Cdd:PRK07798 438 GE-----KVFPEEVEEALKAHPDVADALVVGVPDERWGQEVVAVVQLREG-ARPDLAE----LRAHCRSSLAGYKVPRAI 507
|
570
....*....|...
gi 2025697431 551 EFVLDLPKTITGK 563
Cdd:PRK07798 508 WFVDEVQRSPAGK 520
|
|
| EntE |
COG1021 |
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ... |
60-571 |
3.58e-38 |
|
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 147.60 E-value: 3.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGL--VF-MPG 136
Cdd:COG1021 35 AERHPDRIAV-----VDGERRLSYAELDRRADRLAAGLLA-LGLRPGDRVVVQLPNVAEFVIVFFALFRAGAipVFaLPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 tiqMKSTDILYRLQSSKARAIVAGDEVA-----QEVDAVAPDCSFLKIKLLVSDNrrEGWLNFKTLLKDvSNTHHCVETG 211
Cdd:COG1021 109 ---HRRAEISHFAEQSEAVAYIIPDRHRgfdyrALARELQAEVPSLRHVLVVGDA--GEFTSLDALLAA-PADLSEPRPD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 212 SHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNvSDTVW----------TISDTGwivniltsFLEPWTLG 281
Cdd:COG1021 183 PDDVAFFQLSGGTTGLPKLIPRTHDDYLYSVRASAEIC-GLD-ADTVYlaalpaahnfPLSSPG--------VLGVLYAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 282 ACVfVyLLPKFDPQTVLKVLSSYPIN--SLVgAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIR 359
Cdd:COG1021 253 GTV-V-LAPDPSPDTAFPLIERERVTvtALV-PPLALLWLDAAERSRYDLSSLRVLQVGGAKLSPELARRVRPALGCTLQ 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTEtGLTC--RI--SRTMTVkpGSLGTAVPHYD-VQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPk 432
Cdd:COG1021 330 QVFGMAE-GLVNytRLddPEEVIL--TTQGRPISPDDeVRIVDEDGNPVPPGEVGELLTR-------GpyTIRGYYRAP- 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 433 ktEANIR-----GdFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTR 507
Cdd:COG1021 399 --EHNARaftpdG-FYRTGDLVRRTPDGYLVVEGRAKDQINRGGE-----KIAAEEVENLLLAHPAVHDAAVVAMPDEYL 470
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 508 GEVVKAFVVLAPEFLShdPDQLTKLLQ-QHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:COG1021 471 GERSCAFVVPRGEPLT--LAELRRFLReRGL----AAFKLPDRLEFVDALPLTAVGKIDKKALRA 529
|
|
| A_NRPS_VisG_like |
cd17651 |
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ... |
58-570 |
4.99e-38 |
|
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 146.72 E-value: 4.99e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:cd17651 3 RQAARTPDAPALVA-----EGRRLTYAELDRRANRLAHRLRAR-GVGPGDLVALCARRSAELVVALLAILKAGAAYVPLD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDEVA--QEVDAVAPDCsflkikllvsdnrregWLNFKTLLKDVSNthHCVETGSHEP 215
Cdd:cd17651 77 PAYPAERLAFMLADAGPVLVLTHPALAgeLAVELVAVTL----------------LDQPGAAAGADAE--PDPALDADDL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLG-----LKAKMDADSwtglnvSDTVWTISDTGWIVniltSFLEPW-TL--GACVfvY 287
Cdd:cd17651 139 AYVIYTSGSTGRPKGVVMPHRSLAnlvawQARASSLGP------GARTLQFAGLGFDV----SVQEIFsTLcaGATL--V 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 288 LLP---KFDPQTVLKVLSSYPIN-SLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESL-LPETLENWKAK-TGLYIREF 361
Cdd:cd17651 207 LPPeevRTDPPALAAWLDEQRISrVFLPTVALRALAEHGRPLGVRLAALRYLLTGGEQLvLTEDLREFCAGlPGLRLHNH 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETGL-TCRISRTMTVKPG---SLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKT-EA 436
Cdd:cd17651 287 YGPTETHVvTALSLPGDPAAWPappPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGA-----GLARGYLNRPELTaER 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 437 NIRGDF------WLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:cd17651 362 FVPDPFvpgarmYRTGDLARWLPDGELEFLGRADDQVKIRG-----FRIELGEIEAALARHPGVREAVVLAREDRPGEKR 436
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 511 VKAFVVLAPEflsHDPDqlTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd17651 437 LVAYVVGDPE---APVD--AAELRAALATHLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491
|
|
| BACL_like |
cd05929 |
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ... |
286-571 |
1.08e-37 |
|
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.
Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 145.21 E-value: 1.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 286 VYLLPKFDPQTVLKVLSSYPINSLVGAPLIY-RMLLQQDLSRYKFpHLHS----CYTGGeSLLPETLENWKAKTGLYIRE 360
Cdd:cd05929 197 LVLMEKFDPEEFLRLIERYRVTFAQFVPTMFvRLLKLPEAVRNAY-DLSSlkrvIHAAA-PCPPWVKEQWIDWGGPIIWE 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 361 FYGQTE-TGLTCRISRTMTVKPGSLGTAVPHyDVQVIDEQGNVLPPGKEGDIAirvkpFRPIGIFSgYVDNPKKTEANIR 439
Cdd:cd05929 275 YYGGTEgQGLTIINGEEWLTHPGSVGRAVLG-KVHILDEDGNEVPPGEIGEVY-----FANGPGFE-YTNDPEKTAAARN 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 GDFW-LLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAfvVLA 518
Cdd:cd05929 348 EGGWsTLGDVGYLDEDGYLYLTDRRSDMIISGGVN-----IYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHA--VVQ 420
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 519 PEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05929 421 PAPGADAGTALAEELIAFLRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLLRD 473
|
|
| PRK07787 |
PRK07787 |
acyl-CoA synthetase; Validated |
215-571 |
1.43e-37 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 145.13 E-value: 1.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHSSLGlkAKMD--ADSWTglnvsdtvWTISDTgwIVNILTSF---------LEPWTLGAc 283
Cdd:PRK07787 130 PALIVYTSGTTGPPKGVVLSRRAIA--ADLDalAEAWQ--------WTADDV--LVHGLPLFhvhglvlgvLGPLRIGN- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 284 VFVYLLpKFDPQTVLKVLSSyPINSLVGAPLIY-RMLLQQDLSRYKFPH--LHScytgGESLLPET-LENWKAKTGLYIR 359
Cdd:PRK07787 197 RFVHTG-RPTPEAYAQALSE-GGTLYFGVPTVWsRIAADPEAARALRGArlLVS----GSAALPVPvFDRLAALTGHRPV 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKE--GDIAIRvKPfrpiGIFSGYVDNPKKTEAN 437
Cdd:PRK07787 271 ERYGMTETLITLSTRADGERRPGWVGLPLAGVETRLVDEDGGPVPHDGEtvGELQVR-GP----TLFDGYLNRPDATAAA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWL-LGDRGTKDPEGYFHFIGR-TDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFV 515
Cdd:PRK07787 346 FTADGWFrTGDVAVVDPDGMHRIVGReSTDLIKSGG-----YRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIVAYV 420
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 516 VlapeflSHDPDQLTKLLqQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK07787 421 V------GADDVAADELI-DFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLLS 469
|
|
| FACL_like_4 |
cd05944 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
216-571 |
1.71e-37 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 142.23 E-value: 1.71e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSlglkakMDADSWTGLNVSDtvWTISDTgwivniLTSFLEPWTLGACVFVYLLPKFDPQ 295
Cdd:cd05944 5 AAYFHTGGTTGTPKLAQHTHSN------EVYNAWMLALNSL--FDPDDV------LLCGLPLFHVNGSVVTLLTPLASGA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 296 TVL-----------------KVLSSYPINSLVGAPLIYRMLLQ----QDLSRYKFPhlhscyTGGESLLPETLEN-WKAK 353
Cdd:cd05944 71 HVVlagpagyrnpglfdnfwKLVERYRITSLSTVPTVYAALLQvpvnADISSLRFA------MSGAAPLPVELRArFEDA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 354 TGLYIREFYGQTETglTCRISRTM---TVKPGSLGTAVPHYDVQ--VIDEQGNVL---PPGKEGDIAIRVKpfrpiGIFS 425
Cdd:cd05944 145 TGLPVVEGYGLTEA--TCLVAVNPpdgPKRPGSVGLRLPYARVRikVLDGVGRLLrdcAPDEVGEICVAGP-----GVFG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 426 GYVDNPKKTEANIrGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPD 504
Cdd:cd05944 218 GYLYTEGNKNAFV-ADGWLnTGDLGRLDADGYLFITGRAKDLIIRGG-----HNIDPALIEEALLRHPAVAFAGAVGQPD 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2025697431 505 PTRGEVVKAFVVLAPEfLSHDPDQLTKLLQQHVKSVTApykYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05944 292 AHAGELPVAYVQLKPG-AVVEEEELLAWARDHVPERAA---VPKHIEVLEELPVTAVGKVFKPALRA 354
|
|
| PRK13382 |
PRK13382 |
bile acid CoA ligase; |
218-572 |
2.72e-37 |
|
bile acid CoA ligase;
Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 145.29 E-value: 2.72e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPKMAEHSHS--SLGLKAKMDADSWTGLNVsdtvwtisdtgwiVNILTSFLEPWTLGACVFVYLLP----- 290
Cdd:PRK13382 201 ILLTSGTTGTPKGARRSGPggIGTLKAILDRTPWRAEEP-------------TVIVAPMFHAWGFSQLVLAASLActivt 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 --KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQ---QDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQT 365
Cdd:PRK13382 268 rrRFDPEATLDLIDRHRATGLAVVPVMFDRIMDlpaEVRNRYSGRSLRFAAASGSRMRPDVVIAFMDQFGDVIYNNYNAT 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 366 ETGL-TCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPfrpigIFSGYVdnPKKTEANIRGdFWL 444
Cdd:PRK13382 348 EAGMiATATPADLRAAPDTAGRPAEGTEIRILDQDFREVPTGEVGTIFVRNDT-----QFDGYT--SGSTKDFHDG-FMA 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 445 LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLSH 524
Cdd:PRK13382 420 SGDVGYLDENGRLFVVGRDDEMIVSGGEN-----VYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFVVLKPG-ASA 493
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2025697431 525 DPDQltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PRK13382 494 TPET----LKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQAR 537
|
|
| PLN02246 |
PLN02246 |
4-coumarate--CoA ligase |
58-572 |
6.08e-37 |
|
4-coumarate--CoA ligase
Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 144.35 E-value: 6.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALwwMNGS-GEELkwNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPG 136
Cdd:PLN02246 31 ERLSEFSDRPCL--IDGAtGRVY--TYADVELLSRRVAAGLHK-LGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTDILYRLQSSKARAIVAgdeVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLLKDVSNTHHCVETGSHEPA 216
Cdd:PLN02246 106 NPFYTPAEIAKQAKASGAKLIIT---QSCYVDKLKGLAEDDGVTVVTIDDPPEGCLHFSELTQADENELPEVEISPDDVV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 217 AIYFTSGTSGLPKMAEHSHSSL--GLKAKMDADSWT-GLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVylLPKFD 293
Cdd:PLN02246 183 ALPYSSGTTGLPKGVMLTHKGLvtSVAQQVDGENPNlYFHSDDVILCVLPMFHIYSLNSVLLCGLRVGAAILI--MPKFE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 294 PQTVLKVLSSYPINSlvgAPLIYRMLL---------QQDLSRYKFphlhsCYTGGESLLPETLENWKAK-TGLYIREFYG 363
Cdd:PLN02246 261 IGALLELIQRHKVTI---APFVPPIVLaiakspvveKYDLSSIRM-----VLSGAAPLGKELEDAFRAKlPNAVLGQGYG 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 364 QTETGLTCRIS-----RTMTVKPGSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAIRVKPfrpigIFSGYVDNPKKTEAN 437
Cdd:PLN02246 333 MTEAGPVLAMClafakEPFPVKSGSCGTVVRNAELKIVDpETGASLPRNQPGEICIRGPQ-----IMKGYLNDPEATANT 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVV 516
Cdd:PLN02246 408 IDKDGWLhTGDIGYIDDDDELFIVDRLKELIKYKG-----FQVAPAELEALLISHPSIADAAVVPMKDEVAGEVPVAFVV 482
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 2025697431 517 LAPEF-LSHDPdqltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PLN02246 483 RSNGSeITEDE------IKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDLRAK 533
|
|
| PLN02330 |
PLN02330 |
4-coumarate--CoA ligase-like 1 |
81-572 |
6.16e-37 |
|
4-coumarate--CoA ligase-like 1
Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 144.35 E-value: 6.16e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 81 WNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAG 160
Cdd:PLN02330 56 VTYGEVVRDTRRFAKALRS-LGLRKGQVVVVVLPNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAKLIVTN 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEVAQEVDAvapdcsfLKIKLLV-SDNRREGWLNFKTLLKDVSNthhCVETGSHEP------AAIYFTSGTSGLPKMAEH 233
Cdd:PLN02330 135 DTNYGKVKG-------LGLPVIVlGEEKIEGAVNWKELLEAADR---AGDTSDNEEilqtdlCALPFSSGTTGISKGVML 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 234 SHSSLGLkakmdadswtglNVSDTVWTISD--TGWIVNI-LTSFLEPWTL-GACVF-------VYLLPKFDPQTVLKVLS 302
Cdd:PLN02330 205 THRNLVA------------NLCSSLFSVGPemIGQVVTLgLIPFFHIYGItGICCAtlrnkgkVVVMSRFELRTFLNALI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 303 SYPINSLVGAPLIYRMLLQQ------DLSRYKfphLHSCYTGGESLLPETLENWKAK-TGLYIREFYGQTETglTCrISR 375
Cdd:PLN02330 273 TQEVSFAPIVPPIILNLVKNpiveefDLSKLK---LQAIMTAAAPLAPELLTAFEAKfPGVQVQEAYGLTEH--SC-ITL 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 376 TM--------TVKPGSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWL-L 445
Cdd:PLN02330 347 THgdpekghgIAKKNSVGFILPNLEVKFIDpDTGRSLPKNTPGELCVRSQ-----CVMQGYYNNKEETDRTIDEDGWLhT 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 446 GDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHD 525
Cdd:PLN02330 422 GDIGYIDDDGDIFIVDRIKELIKYKG-----FQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPAACVVINPKAKESE 496
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 2025697431 526 PDQLtkllqQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PLN02330 497 EDIL-----NFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRLLKEK 538
|
|
| CBAL |
cd05923 |
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ... |
85-569 |
2.81e-35 |
|
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.
Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 138.80 E-value: 2.81e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 85 ELSEISQRAANVLSGpcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDeVA 164
Cdd:cd05923 34 LRARIEAVAARLHAR--GLRPGQRVAVVLPNSVEAVIALLALHRLGAVPALINPRLKAAELAELIERGEMTAAVIAV-DA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 165 QEVDAVAPdcSFLKIkLLVSDNRREGWL-NFKTLLKDVSnthhcveTGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAK 243
Cdd:cd05923 111 QVMDAIFQ--SGVRV-LALSDLVGLGEPeSAGPLIEDPP-------REPEQPAFVFYTSGTTGLPKGAVIPQRAAESRVL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 244 MDAdSWTGL-----NVSDTVWTISDTgwiVNILTSFLEPWTLGAcvFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRM 318
Cdd:cd05923 181 FMS-TQAGLrhgrhNVVLGLMPLYHV---IGFFAVLVAALALDG--TYVVVEEFDPADALKLIEQERVTSLFATPTHLDA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 319 LLQQDL-SRYKFPHLHSCYTGGESL---LPETLENwkAKTGLYIrEFYGQTETgLTCRISRTmtVKPGSLGTAVPHYDVQ 394
Cdd:cd05923 255 LAAAAEfAGLKLSSLRHVTFAGATMpdaVLERVNQ--HLPGEKV-NIYGTTEA-MNSLYMRD--ARTGTEMRPGFFSEVR 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 395 VIDEQGNV---LPPGKEGDIAIRVKPfrpIGIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSG 471
Cdd:cd05923 329 IVRIGGSPdeaLANGEEGELIVAAAA---DAAFTGYLNQPEATAKKLQDGWYRTGDVGYVDPSGDVRILGRVDDMIISGG 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 472 TSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFLSHDpdqltKLLQQHVKSVTAPYKYPRKVE 551
Cdd:cd05923 406 EN-----IHPSEIERVLSRHPGVTEVVVIGVADERWGQSVTACVVPREGTLSAD-----ELDQFCRASELADFKRPRRYF 475
|
490
....*....|....*...
gi 2025697431 552 FVLDLPKTITGKIERAKL 569
Cdd:cd05923 476 FLDELPKNAMNKVLRRQL 493
|
|
| PRK08162 |
PRK08162 |
acyl-CoA synthetase; Validated |
77-572 |
7.48e-34 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 135.46 E-value: 7.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 77 EELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARA 156
Cdd:PRK08162 40 GDRRRTWAETYARCRRLASALAR-RGIGRGDTVAVLLPNIPAMVEAHFGVPMAGAVLNTLNTRLDAASIAFMLRHGEAKV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 157 IVAGDEVAQEVDAVAPDCSFLKIkLLV-------SDNRREGWLNFKTLLkdvsnthhcvETGSHE-----PA------AI 218
Cdd:PRK08162 119 LIVDTEFAEVAREALALLPGPKP-LVIdvddpeyPGGRFIGALDYEAFL----------ASGDPDfawtlPAdewdaiAL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 219 YFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVWTISD---TGWivniltSFlePWTLGACVFVYL-LPKFDP 294
Cdd:PRK08162 188 NYTSGTTGNPKGVVYHHRGAYLNALSNILAWGMPKHPVYLWTLPMfhcNGW------CF--PWTVAARAGTNVcLRKVDP 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 295 QTVLKVLSSYPINSLVGAPLIYRMLLQ-QDLSRYKFPHLHSCYTGGESLLPETLENWKAkTGLYIREFYGQTET-Gltcr 372
Cdd:PRK08162 260 KLIFDLIREHGVTHYCGAPIVLSALINaPAEWRAGIDHPVHAMVAGAAPPAAVIAKMEE-IGFDLTHVYGLTETyG---- 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 373 isrtmtvkPGSLGTAVPHYDVQVIDE-------QG---------NVLPP---------GKE-GDIAirvkpFRPIGIFSG 426
Cdd:PRK08162 335 --------PATVCAWQPEWDALPLDEraqlkarQGvryplqegvTVLDPdtmqpvpadGETiGEIM-----FRGNIVMKG 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 427 YVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPT 506
Cdd:PRK08162 402 YLKNPKATEEAFAGGWFHTGDLAVLHPDGYIKIKDRSKDIIISGGEN-----ISSIEVEDVLYRHPAVLVAAVVAKPDPK 476
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 507 RGEVVKAFVVLAPEfLSHDPDQLTkllqQHVKSVTAPYKYPRKVEFVlDLPKTITGKIERAKLRAK 572
Cdd:PRK08162 477 WGEVPCAFVELKDG-ASATEEEII----AHCREHLAGFKVPKAVVFG-ELPKTSTGKIQKFVLREQ 536
|
|
| PRK05852 |
PRK05852 |
fatty acid--CoA ligase family protein; |
49-566 |
2.07e-33 |
|
fatty acid--CoA ligase family protein;
Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 134.24 E-value: 2.07e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 49 DVVDHwanmeKAGKRPPRPALWWmngSGEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIR 128
Cdd:PRK05852 20 DLVEV-----AATRLPEAPALVV---TADRIAISYRDLARLVDDLAGQLTRS-GLLPGDRVALRMGSNAEFVVALLAASR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 129 TGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKtlLKDVSNTHHCV 208
Cdd:PRK05852 91 ADLVVVPLDPALPIAEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVH--LDAATEPTPAT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 209 ETGS---HEPAAIYFTSGTSGLPKMAehshsslglkakmdadSWTGLNVSDTVWTI--------SDTGWIV-------NI 270
Cdd:PRK05852 169 STPEglrPDDAMIMFTGGTTGLPKMV----------------PWTHANIASSVRAIitgyrlspRDATVAVmplyhghGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 271 LTSFLEPWTLGACVfvyLLP---KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ---DLSRYKFPHLHSCYTGGESLLP 344
Cdd:PRK05852 233 IAALLATLASGGAV---LLPargRFSAHTFWDDIKAVGATWYTAVPTIHQILLERaatEPSGRKPAALRFIRSCSAPLTA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 345 ETLENWKAKTGLYIREFYGQTET----------GLTCRISRTMTVKPGSLGTAVphyDVQVIDEQGNVLPPGKEGDIAIR 414
Cdd:PRK05852 310 ETAQALQTEFAAPVVCAFGMTEAthqvtttqieGIGQTENPVVSTGLVGRSTGA---QIRIVGSDGLPLPAGAVGEVWLR 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 415 VKPfrpigIFSGYVDNPKKTEANIRgDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPA 493
Cdd:PRK05852 387 GTT-----VVRGYLGDPTITAANFT-DGWLrTGDLGSLSAAGDLSIRGRIKELINRGGE-----KISPERVEGVLASHPN 455
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 494 VAETVVISSPDPTRGEVVKAfVVLAPEFLSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIER 566
Cdd:PRK05852 456 VMEAAVFGVPDQLYGEAVAA-VIVPRESAPPTAEELVQFCRERL----AAFEIPASFQEASGLPHTAKGSLDR 523
|
|
| PtmA |
cd17636 |
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ... |
214-562 |
3.93e-33 |
|
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 129.34 E-value: 3.93e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSwTGLNvSDTVWTISdtGWIVNILTSFlepWTL------GACVFVy 287
Cdd:cd17636 1 DPVLAIYTAAFSGRPNGALLSHQALLAQALVLAVL-QAID-EGTVFLNS--GPLFHIGTLM---FTLatfhagGTNVFV- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 288 llPKFDPQTVLKVLSSYPINS-LVGAPLIYRMLLQQDLSRYKFPHLHSCYT--GGESLLPETLENWKAKTGLYirefyGQ 364
Cdd:cd17636 73 --RRVDAEEVLELIEAERCTHaFLLPPTIDQIVELNADGLYDLSSLRSSPAapEWNDMATVDTSPWGRKPGGY-----GQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 365 TE-TGLTCRISRTMTVKpGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrpiG--IFSGYVDNPKKTEANIRGD 441
Cdd:cd17636 146 TEvMGLATFAALGGGAI-GGAGRPSPLVQVRILDEDGREVPDGEVGEIVAR-------GptVMAGYWNRPEVNARRTRGG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 442 FWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEf 521
Cdd:cd17636 218 WHHTNDLGRREPDGSLSFVGPKTRMIKSGAEN-----IYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKAIVVLKPG- 291
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2025697431 522 LSHDPDQLTkllqQHVKSVTAPYKYPRKVEFVLDLPKTITG 562
Cdd:cd17636 292 ASVTEAELI----EHCRARIASYKKPKSVEFADALPRTAGG 328
|
|
| AFD_YhfT-like |
cd17633 |
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ... |
215-566 |
6.01e-33 |
|
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain
Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 128.68 E-value: 6.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHsslglkakmdaDSWTG---LNVSDTVWTISDTGWIVNILTSFLepwTLGACVF------ 285
Cdd:cd17633 2 PFYIGFTSGTTGLPKAYYRSE-----------RSWIEsfvCNEDLFNISGEDAILAPGPLSHSL---FLYGAISalylgg 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 286 -VYLLPKFDPQTVLKVLSSYPINSLVGAPliyrMLLQQdLSRYKFPHLH--SCYTGGESLLPETLENWKA---KTGLYir 359
Cdd:cd17633 68 tFIGQRKFNPKSWIRKINQYNATVIYLVP----TMLQA-LARTLEPESKikSIFSSGQKLFESTKKKLKNifpKANLI-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGnvlppGKEGDIAIRVKPFrpigiFSGYVDnpkktEANIR 439
Cdd:cd17633 141 EFYGTSELSFITYNFNQESRPPNSVGRPFPNVEIEIRNADG-----GEIGKIFVKSEMV-----FSGYVR-----GGFSN 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 GDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLa 518
Cdd:cd17633 206 PDGWMsVGDIGYVDEEGYLYLVGRESDMIIIGG-----INIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIAVALYSG- 279
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2025697431 519 peflshdpDQLT-KLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIER 566
Cdd:cd17633 280 --------DKLTyKQLKRFLKQKLSRYEIPKKIIFVDSLPYTSSGKIAR 320
|
|
| PRK07867 |
PRK07867 |
acyl-CoA synthetase; Validated |
66-578 |
8.88e-33 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 132.11 E-value: 8.88e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 66 RPALWWmngsgEELKWNFRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVfMPGTIQMKSTDI 145
Cdd:PRK07867 19 DRGLYF-----EDSFTSWREHIRGSAARAAALRARLDPTRPPHVGVLLDNTPEFSLLLGAAALSGIV-PVGLNPTRRGAA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 146 LYR-LQSSKARAIVAGDEVAQEVDAVAPDCSFLkikllvsDNRREGWlnfktllKDVSNTHHCVETGSHEPAA-----IY 219
Cdd:PRK07867 93 LARdIAHADCQLVLTESAHAELLDGLDPGVRVI-------NVDSPAW-------ADELAAHRDAEPPFRVADPddlfmLI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 220 FTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTV-----WTISDT---GWIVniltsflepwTLGACVFVYLLPK 291
Cdd:PRK07867 159 FTSGTSGDPKAVRCTHRKVASAGVMLAQRF-GLGPDDVCyvsmpLFHSNAvmaGWAV----------ALAAGASIALRRK 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 FDPQTVLKVLSSYPINSL--VGAPLIYRMLLQQDLSRYKFPhLHSCYtGGESLlPETLENWKAKTGLYIREFYGQTETGL 369
Cdd:PRK07867 228 FSASGFLPDVRRYGATYAnyVGKPLSYVLATPERPDDADNP-LRIVY-GNEGA-PGDIARFARRFGCVVVDGFGSTEGGV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 370 TcrISRTMTVKPGSLGTAVPhyDVQVID-EQGNVLPPGkEGDIAIRVKPFRPIG---------IFSGYVDNPKKTEANIR 439
Cdd:PRK07867 305 A--ITRTPDTPPGALGPLPP--GVAIVDpDTGTECPPA-EDADGRLLNADEAIGelvntagpgGFEGYYNDPEADAERMR 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 GDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAP 519
Cdd:PRK07867 380 GGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGEN-----LGTAPIERILLRYPDATEVAVYAVPDPVVGDQVMAALVLAP 454
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 520 --EFlshDPDQLTKLLqqHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG 578
Cdd:PRK07867 455 gaKF---DPDAFAEFL--AAQPDLGPKQWPSYVRVCAELPRTATFKVLKRQLSAEGVDCAD 510
|
|
| A_NRPS_Srf_like |
cd12117 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ... |
58-569 |
1.92e-32 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.
Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 130.40 E-value: 1.92e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:cd12117 5 EQAARTPDAVAVVY-----GDRSLTYAELNERANRLARRLRAA-GVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAPDcsflkikLLVSDNRREGwlnfktllkDVSNTHHCVETGShePAA 217
Cdd:cd12117 79 PELPAERLAFMLADAGAKVLLTDRSLAGRAGGLEVA-------VVIDEALDAG---------PAGNPAVPVSPDD--LAY 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPK--MAEHsHSSLGLKAKmdaDSWTGLNVSDTVWTISDTGWIVniltSFLEPW-TL--GACVfvYLLPK- 291
Cdd:cd12117 141 VMYTSGSTGRPKgvAVTH-RGVVRLVKN---TNYVTLGPDDRVLQTSPLAFDA----STFEIWgALlnGARL--VLAPKg 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 --FDPQTVLKVLSSYPINSL-VGAPLiYRMLLQQDLSRykFPHLHSCYTGGESLLPETLENWKAKT-GLYIREFYGQTET 367
Cdd:cd12117 211 tlLDPDALGALIAEEGVTVLwLTAAL-FNQLADEDPEC--FAGLRELLTGGEVVSPPHVRRVLAACpGLRLVNGYGPTEN 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 ---GLTCRISRTMTVkPGSL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTE----ANI 438
Cdd:cd12117 288 ttfTTSHVVTELDEV-AGSIpiGRPIANTRVYVLDEDGRPVPPGVPGELYVG-----GDGLALGYLNRPALTAerfvADP 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 439 RGD---FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPD-PTRGEVVkAF 514
Cdd:cd12117 362 FGPgerLYRTGDLARWLPDGRLEFLGRIDDQVKIRG-----FRIELGEIEAALRAHPGVREAVVVVREDaGGDKRLV-AY 435
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 515 VVLAPEFlshDPDQltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd12117 436 VVAEGAL---DAAE----LRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
|
|
| FADD10 |
cd17635 |
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ... |
214-566 |
8.59e-32 |
|
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.
Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 125.84 E-value: 8.59e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLglKAKMDADSWTGLNvsdtvWTISDTGWIVNILTSFLEPWTLGACVF-----VYL 288
Cdd:cd17635 2 DPLAVIFTSGTTGEPKAVLLANKTF--FAVPDILQKEGLN-----WVVGDVTYLPLPATHIGGLWWILTCLIhgglcVTG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 289 LPKFDPQTVLKVLSSYPINSLVGAP--LIYRMLLQQDLSRYKfPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTE 366
Cdd:cd17635 75 GENTTYKSLFKILTTNAVTTTCLVPtlLSKLVSELKSANATV-PSLRLIGYGGSRAIAADVRFIEATGLTNTAQVYGLSE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 367 TGLTCRISRTMTVKP-GSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPFrpigiFSGYVDNPKKTEANIRGDFWLL 445
Cdd:cd17635 154 TGTALCLPTDDDSIEiNAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPAN-----MLGYWNNPERTAEVLIDGWVNT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 446 GDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEflshD 525
Cdd:cd17635 229 GDLGERREDGFLFITGRSSESINCGGV-----KIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAVVASAE----L 299
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2025697431 526 PDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIER 566
Cdd:cd17635 300 DENAIRALKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
|
|
| A_NRPS_PvdJ-like |
cd17649 |
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ... |
64-570 |
1.93e-31 |
|
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 127.10 E-value: 1.93e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiqmkst 143
Cdd:cd17649 1 PDAVALVF-----GDQSLSYAELDARANRLAHRLRA-LGVGPEVRVGIALERSLEMVVALLAILKAGGAYVP-------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 144 dilyrlqsskaraivagdevaqevdaVAPDCSFLKIKLLVSDNRregwlnFKTLLkdvsnTHHcvetgSHEPAAIYFTSG 223
Cdd:cd17649 67 --------------------------LDPEYPAERLRYMLEDSG------AGLLL-----THH-----PRQLAYVIYTSG 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 224 TSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTV---WTISDTGWIvnilTSFLEPWTLGACVFVYLLPKF-DPQTVLK 299
Cdd:cd17649 105 STGTPKGVAVSHGPLAAHCQATAERY-GLTPGDRElqfASFNFDGAH----EQLLPPLICGACVVLRPDELWaSADELAE 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 300 VLSSYPINSLVGAPLIYRMLLQQ--DLSRYKFPHLHSCYTGGESLLPETLENWkAKTGLYIREFYGQTETGLT---CRIS 374
Cdd:cd17649 180 MVRELGVTVLDLPPAYLQQLAEEadRTGDGRPPSLRLYIFGGEALSPELLRRW-LKAPVRLFNAYGPTEATVTplvWKCE 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 375 RTMTVKPGSL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKT-EANIRGDFWLLGDR--G 449
Cdd:cd17649 259 AGAARAGASMpiGRPLGGRSAYILDADLNPVPVGVTGELYIGGE-----GLARGYLGRPELTaERFVPDPFGAPGSRlyR 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 450 TKD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVkAFVVL-APEFLS 523
Cdd:cd17649 334 TGDlarwrDDGVIEYLGRVDHQVKIRG-----FRIELGEIEAALLEHPGVREAAVVALDGAGGKQLV-AYVVLrAAAAQP 407
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 2025697431 524 HDPDQltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd17649 408 ELRAQ----LRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
|
|
| PRK06164 |
PRK06164 |
acyl-CoA synthetase; Validated |
37-574 |
3.53e-31 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 127.55 E-value: 3.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 37 HQEIPAKFNFANDVVDHwanmekAGKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLsGPCGLQRGDRVAVVLSQV 116
Cdd:PRK06164 3 HDAAPRADTLASLLDAH------ARARPDAVAL-----IDEDRPLSRAELRALVDRLAAWL-AAQGVRRGDRVAVWLPNC 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 117 PEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAG------------DEVAQEVDAVAPdcsflKIKLLVS 184
Cdd:PRK06164 71 IEWVVLFLACARLGATVIAVNTRYRSHEVAHILGRGRARWLVVWpgfkgidfaailAAVPPDALPPLR-----AIAVVDD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 185 DNR------REGWLNFKTLLKDVSNTHHCVETGSHEPAAIYFT-SGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDT 257
Cdd:PRK06164 146 AADatpapaPGARVQLFALPDPAPPAAAGERAADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAY-GYDPGAV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 258 VWTISDTGWIVNiLTSFLEpwTLGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCyt 337
Cdd:PRK06164 225 LLAALPFCGVFG-FSTLLG--ALAGGAPLVCEPVFDAARTARALRRHRVTHTFGNDEMLRRILDTAGERADFPSARLF-- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 338 GGESLLP--ETLENWKAKTGLYIREFYGQTET-GLTCRISRTMTVKPGSLGTAVPHY---DVQVIDEQ-GNVLPPGKEGD 410
Cdd:PRK06164 300 GFASFAPalGELAALARARGVPLTGLYGSSEVqALVALQPATDPVSVRIEGGGRPASpeaRVRARDPQdGALLPDGESGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 411 IAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALM 489
Cdd:PRK06164 380 IEIRAP-----SLMRGYLDNPDATARALTDDGYFrTGDLGYTRGDGQFVYQTRMGDSLRLGG-----FLVNPAEIEHALE 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 490 EHPAVAETVVISSPDPTRGEVVkAFVVLAPeflSHDPDQltKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITG---KIER 566
Cdd:PRK06164 450 ALPGVAAAQVVGATRDGKTVPV-AFVIPTD---GASPDE--AGLMAACREALAGFKVPARVQVVEAFPVTESAngaKIQK 523
|
570
....*....|
gi 2025697431 567 AKLR--AKEW 574
Cdd:PRK06164 524 HRLRemAQAR 533
|
|
| A_NRPS_AB3403-like |
cd17646 |
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ... |
58-569 |
1.01e-30 |
|
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 125.47 E-value: 1.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngSGEELkwNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:cd17646 6 EQAARTPDAPAVVD---EGRTL--TYRELDERANRLAHLLRAR-GVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARaIVAGDEVAQEVDAVAPDcsflkIKLLVSdnrregwlnfkTLLKDVSNTHHCVETGSHEPAA 217
Cdd:cd17646 80 PGYPADRLAYMLADAGPA-VVLTTADLAARLPAGGD-----VALLGD-----------EALAAPPATPPLVPPRPDNLAY 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPKMAEHSHSS-----LGLKAKMdadswtGLNVSDTVWTISDTGWIVNILTSFlepWTL--GACVfVYLLP 290
Cdd:cd17646 143 VIYTSGSTGRPKGVMVTHAGivnrlLWMQDEY------PLGPGDRVLQKTPLSFDVSVWELF---WPLvaGARL-VVARP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 --KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYkfPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTET 367
Cdd:cd17646 213 ggHRDPAYLAALIREHGVTTCHFVPSMLRVFLAEpAAGSC--ASLRRVFCSGEALPPELAARFLALPGAELHNLYGPTEA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GLT---CRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGD--- 441
Cdd:cd17646 291 AIDvthWPVRGPAETPSVPIGRPVPNTRLYVLDDALRPVPVGVPGELYLG-----GVQLARGYLGRPALTAERFVPDpfg 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 442 ----FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVL 517
Cdd:cd17646 366 pgsrMYRTGDLARWRPDGALEFLGRSDDQVKIRG-----FRVEPGEIEAALAAHPAVTHAVVVARAAPAGAARLVGYVVP 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 518 APEFLSHDPDQltklLQQHVKSVTAPYKYPrKVEFVLD-LPKTITGKIERAKL 569
Cdd:cd17646 441 AAGAAGPDTAA----LRAHLAERLPEYMVP-AAFVVLDaLPLTANGKLDRAAL 488
|
|
| A_NRPS_Ta1_like |
cd12116 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ... |
64-569 |
1.77e-30 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.
Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 124.71 E-value: 1.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALwwmngSGEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKST 143
Cdd:cd12116 1 PDATAV-----RDDDRSLSYAELDERANRLAARLRAR-GVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPAD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 144 DILYRLQSSKARAIVAGDEVAQevdavAPDCSFLKIKLLvsdnrregwlnfktlLKDVSNTHHCVETG--SHEPAAIYFT 221
Cdd:cd12116 75 RLRYILEDAEPALVLTDDALPD-----RLPAGLPVLLLA---------------LAAAAAAPAAPRTPvsPDDLAYVIYT 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 222 SGTSGLPKMAEHSHSSL-GLKAKMDADswTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVfvyLLPK---FDPQTV 297
Cdd:cd12116 135 SGSTGRPKGVVVSHRNLvNFLHSMRER--LGLGPGDRLLAVTTYAFDISLLELLLPLLAGARVV---IAPRetqRDPEAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 298 LKVLSSYPINSLVGAPLIYRMLLQQDLSryKFPHLHS-CytGGESLLPETLENWKAKTG-LYirEFYGQTETGLTCRISR 375
Cdd:cd12116 210 ARLIEAHSITVMQATPATWRMLLDAGWQ--GRAGLTAlC--GGEALPPDLAARLLSRVGsLW--NLYGPTETTIWSTAAR 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 376 -TMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGD--------FWLLG 446
Cdd:cd12116 284 vTAAAGPIPIGRPLANTQVYVLDAALRPVPPGVPGELYIG-----GDGVAQGYLGRPALTAERFVPDpfagpgsrLYRTG 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVkAFVVLApEFLSHDP 526
Cdd:cd12116 359 DLVRRRADGRLEYLGRADGQVKIRG-----HRIELGEIEAALAAHPGVAQAAVVVREDGGDRRLV-AYVVLK-AGAAPDA 431
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2025697431 527 DQLTKLLQQHVKSVTAPYKYprkveFVLD-LPKTITGKIERAKL 569
Cdd:cd12116 432 AALRAHLRATLPAYMVPSAF-----VRLDaLPLTANGKLDRKAL 470
|
|
| A_NRPS_Bac |
cd17655 |
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ... |
58-569 |
2.90e-30 |
|
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 124.36 E-value: 2.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:cd17655 5 EQAEKTPDHTAVVF-----EDQTLTYRELNERANQLARTLREK-GVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPID 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDEVAQEVDavapdcsflKIKLLVSDNRREGWLNFKTLLKDVSNTHHCvetgshepAA 217
Cdd:cd17655 79 PDYPEERIQYILEDSGADILLTQSHLQPPIA---------FIGLIDLLDEDTIYHEESENLEPVSKSDDL--------AY 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPK--MAEH---SHSSLGLKAKMDADswTGLNVSdTVWTISDTGWIVNILTSFLepwtLGACVFVYllPK- 291
Cdd:cd17655 142 VIYTSGSTGKPKgvMIEHrgvVNLVEWANKVIYQG--EHLRVA-LFASISFDASVTEIFASLL----SGNTLYIV--RKe 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 --FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSryKFPHLHSCYTGGESLLPETLENWKAKTGLYIREF--YGQTET 367
Cdd:cd17655 213 tvLDGQALTQYIRQNRITIIDLTPAHLKLLDAADDS--EGLSLKHLIVGGEALSTELAKKIIELFGTNPTITnaYGPTET 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GLTCRI-----SRTMTVKPgSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDF 442
Cdd:cd17655 291 TVDASIyqyepETDQQVSV-PIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGE-----GVARGYLNRPELTAEKFVDDP 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 443 WLLGDR--GTKD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFV 515
Cdd:cd17655 365 FVPGERmyRTGDlarwlPDGNIEFLGRIDHQVKIRG-----YRIELGEIEARLLQHPDIKEAVVIARKDEQGQNYLCAYI 439
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 516 VLAPEFlshDPDQLTKLLQQHVKSVTAPyKYPRKVEfvlDLPKTITGKIERAKL 569
Cdd:cd17655 440 VSEKEL---PVAQLREFLARELPDYMIP-SYFIKLD---EIPLTPNGKVDRKAL 486
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
58-569 |
5.18e-30 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 126.61 E-value: 5.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLsgpcgLQRG----DRVAVVLSQVPEWWLVTLGCIRTGLVF 133
Cdd:PRK12316 4559 ERARMTPDAVAVVF-----DEEKLTYAELNRRANRLAHAL-----IARGvgpeVLVGIAMERSAEMMVGLLAVLKAGGAY 4628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 134 MPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVAP-DCSFLkikllvsdNRREGWLNFktllkdvSNTHHCVETGS 212
Cdd:PRK12316 4629 VPLDPEYPRERLAYMMEDSGAALLLTQSHLLQRLPIPDGlASLAL--------DRDEDWEGF-------PAHDPAVRLHP 4693
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYFTSGTSGLPKMAEHSHSSLglkakMDADSWTG----LNVSDTVWTISDTGWIVNILtSFLEPWTLGACVFVYL 288
Cdd:PRK12316 4694 DNLAYVIYTSGSTGRPKGVAVSHGSL-----VNHLHATGeryeLTPDDRVLQFMSFSFDGSHE-GLYHPLINGASVVIRD 4767
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 289 LPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETL-ENWKAKTGLYIREFYGQTET 367
Cdd:PRK12316 4768 DSLWDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAERDGEPPSLRVYCFGGEAVAQASYdLAWRALKPVYLFNGYGPTET 4847
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GLT--CRISRTMTVkPGS----LGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGD 441
Cdd:PRK12316 4848 TVTvlLWKARDGDA-CGAaympIGTPLGNRSGYVLDGQLNPLPVGVAGELYLGGE-----GVARGYLERPALTAERFVPD 4921
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 442 --------FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKA 513
Cdd:PRK12316 4922 pfgapggrLYRTGDLARYRADGVIDYLGRVDHQVKIRG-----FRIELGEIEARLREHPAVREAVVIAQEGAVGKQLVGY 4996
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 514 FVVLAPEFLSHDPDQ--LTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK12316 4997 VVPQDPALADADEAQaeLRDELKAALRERLPEYMVPAHLVFLARMPLTPNGKLDRKAL 5054
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
58-571 |
1.04e-29 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 124.97 E-value: 1.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgt 137
Cdd:COG1020 484 AQAARTPDAVAVVF-----GDQSLTYAELNARANRLAHHLRA-LGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVP-- 555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IqmkstD-------ILYRLQSSKARAIVAGDEVAQEVDAVApdcsflkIKLLVSDnrregwlnfKTLLKDVSNTHHCVET 210
Cdd:COG1020 556 L-----DpaypaerLAYMLEDAGARLVLTQSALAARLPELG-------VPVLALD---------ALALAAEPATNPPVPV 614
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 211 GSHEPAAIYFTSGTSGLPKMAEHSHSSLG--LKAKMDadsWTGLNVSDTV---WTIS-DTgwivniltSFLE---PWTLG 281
Cdd:COG1020 615 TPDDLAYVIYTSGSTGRPKGVMVEHRALVnlLAWMQR---RYGLGPGDRVlqfASLSfDA--------SVWEifgALLSG 683
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 282 ACVfvYLLPK---FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRykFPHLHSCYTGGESLLPETLENWKAKT-GLY 357
Cdd:COG1020 684 ATL--VLAPPearRDPAALAELLARHRVTVLNLTPSLLRALLDAAPEA--LPSLRLVLVGGEALPPELVRRWRARLpGAR 759
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 358 IREFYGQTETGLTCRISRTMTVKPGS----LGTAVPHYDVQVIDEQGNVLPPGKEGDIAI------RvkpfrpigifsGY 427
Cdd:COG1020 760 LVNLYGPTETTVDSTYYEVTPPDADGgsvpIGRPIANTRVYVLDAHLQPVPVGVPGELYIggaglaR-----------GY 828
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 428 VDNPKKT-EANIRGDFWLL-------GDRGTKDPEGYFHFIGRTDD---IinssgtsfcR-YRIGPSEVENALMEHPAVA 495
Cdd:COG1020 829 LNRPELTaERFVADPFGFPgarlyrtGDLARWLPDGNLEFLGRADDqvkI---------RgFRIELGEIEAALLQHPGVR 899
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 496 ETVVISSPDPTRGEVVKAFVVLAPEflshdPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:COG1020 900 EAVVVAREDAPGDKRLVAYVVPEAG-----AAAAAALLRLALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPA 970
|
|
| OSB_MenE-like |
cd17630 |
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ... |
214-572 |
1.26e-29 |
|
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.
Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 119.36 E-value: 1.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLgLKAKMDADSWTGLNVSDtvwtisdtGWIVN-----------ILTSFLEPWTLga 282
Cdd:cd17630 1 RLATVILTSGSTGTPKAVVHTAANL-LASAAGLHSRLGFGGGD--------SWLLSlplyhvgglaiLVRSLLAGAEL-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 cvfvYLLPKFDPqtVLKVLSSYPIN--SLVGAPLiyRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKtGLYIRE 360
Cdd:cd17630 70 ----VLLERNQA--LAEDLAPPGVThvSLVPTQL--QRLLDSGQGPAALKSLRAVLLGGAPIPPELLERAADR-GIPLYT 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 361 FYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQvIDEQGNVLPPGKegdiairvkpfrpiGIFSGYVDNPKKTEANIRG 440
Cdd:cd17630 141 TYGMTETASQVATKRPDGFGRGGVGVLLPGRELR-IVEDGEIWVGGA--------------SLAMGYLRGQLVPEFNEDG 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 441 dfWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAP 519
Cdd:cd17630 206 --WFtTKDLGELHADGRLTVLGRADNMIISGG-----ENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRG 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 520 EflsHDPDQltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:cd17630 279 P---ADPAE----LRAWLKDKLARFKLPKRIYPVPELPRTGGGKVDRRALRAW 324
|
|
| PRK07638 |
PRK07638 |
acyl-CoA synthetase; Validated |
83-570 |
1.60e-29 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 122.20 E-value: 1.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRgdRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDe 162
Cdd:PRK07638 29 YKDWFESVCKVANWLNEKESKNK--TIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDELKERLAISNADMIVTER- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 vaqevdavapdcsFLKIKLLVSDNRREGWLNFKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSlglka 242
Cdd:PRK07638 106 -------------YKLNDLPDEEGRVIEIDEWKRMIEKYLPTYAPIENVQNAPFYMGFTSGSTGKPKAFLRAQQS----- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 243 kmdadsWT-GLNVSDTVWTISDTgwivnilTSFLEPWTLGACVF-------------VYLLPKFDPQTVLKVLSSYPINS 308
Cdd:PRK07638 168 ------WLhSFDCNVHDFHMKRE-------DSVLIAGTLVHSLFlygaistlyvgqtVHLMRKFIPNQVLDKLETENISV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 309 LVGAPLIYRMLLQQDlsryKFP-HLHSCYTGGESLLPETLEnwKAKT-----GLYirEFYGQTETG-LTCRISRTMTVKP 381
Cdd:PRK07638 235 MYTVPTMLESLYKEN----RVIeNKMKIISSGAKWEAEAKE--KIKNifpyaKLY--EFYGASELSfVTALVDEESERRP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 382 GSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPFRpigiFSGYV-DNPKKTEANIRGdfWL-LGDRGTKDPEGYFHF 459
Cdd:PRK07638 307 NSVGRPFHNVQVRICNEAGEEVQKGEIGTVYVK-SPQF----FMGYIiGGVLARELNADG--WMtVRDVGYEDEEGFIYI 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 460 IGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVvlapeflshDPDQLTKLLQQHVKS 539
Cdd:PRK07638 380 VGREKNMILFGGIN-----IFPEEIESVLHEHPAVDEIVVIGVPDSYWGEKPVAII---------KGSATKQQLKSFCLQ 445
|
490 500 510
....*....|....*....|....*....|.
gi 2025697431 540 VTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK07638 446 RLSSFKIPKEWHFVDEIPYTNSGKIARMEAK 476
|
|
| A_NRPS_GliP_like |
cd17653 |
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ... |
78-570 |
1.02e-28 |
|
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 118.95 E-value: 1.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWN---FRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKA 154
Cdd:cd17653 17 ESLGGsltYGELDAASNALANRLL-QLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAKLPSARIQAILRTSGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 155 RaivagdevaqevdavapdcsflkikLLVSDNRregwlnfktllkdvsnthhcvetgSHEPAAIYFTSGTSGLPKMAEHS 234
Cdd:cd17653 96 T-------------------------LLLTTDS------------------------PDDLAYIIFTSGSTGIPKGVMVP 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 235 HSSLglkakMDADSWTGLN----VSDTVWTISDTGWIVNILTSFLepwTLGACVFVYLLPKFDP-QTVLKVLSSYPINsl 309
Cdd:cd17653 127 HRGV-----LNYVSQPPARldvgPGSRVAQVLSIAFDACIGEIFS---TLCNGGTLVLADPSDPfAHVARTVDALMST-- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 310 vgaPLIYRMLLQQDlsrykFPHLHSCYTGGESLLPETLENWKAKTGLYirEFYGQTETGLTCRISRTMTVKPGSLGTAVP 389
Cdd:cd17653 197 ---PSILSTLSPQD-----FPNLKTIFLGGEAVPPSLLDRWSPGRRLY--NAYGPTECTISSTMTELLPGQPVTIGKPIP 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 390 HYDVQVIDEQGNVLPPGKEGDIAIrvkpfRPIGIFSGYVDNPKKT-EANIRGDFW------LLGDRGTKDPEGYFHFIGR 462
Cdd:cd17653 267 NSTCYILDADLQPVPEGVVGEICI-----SGVQVARGYLGNPALTaSKFVPDPFWpgsrmyRTGDYGRWTEDGGLEFLGR 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 463 TDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISspdpTRGEVVKAFVvlAPEflSHDPDQLTKLLQQHVKSvta 542
Cdd:cd17653 342 EDNQVKVRG-----FRINLEEIEEVVLQSQPEVTQAAAI----VVNGRLVAFV--TPE--TVDVDGLRSELAKHLPS--- 405
|
490 500
....*....|....*....|....*...
gi 2025697431 543 pYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd17653 406 -YAVPDRIIALDSFPLTANGKVDRKALR 432
|
|
| PLN02479 |
PLN02479 |
acetate-CoA ligase |
79-572 |
1.16e-28 |
|
acetate-CoA ligase
Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 120.33 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 79 LKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIV 158
Cdd:PLN02479 44 VRYTWAQTYQRCRRLASALAKR-SIGPGSTVAVIAPNIPAMYEAHFGVPMAGAVVNCVNIRLNAPTIAFLLEHSKSEVVM 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 159 agdeVAQEVDAVAPDCsfLKIkllVSDNRREgwlNFKTLLKDVSNTHHC-------------------VETGSHE----- 214
Cdd:PLN02479 123 ----VDQEFFTLAEEA--LKI---LAEKKKS---SFKPPLLIVIGDPTCdpkslqyalgkgaieyekfLETGDPEfawkp 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PA------AIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDT-VWTISD---TGWIVniltsflePWTLGA-C 283
Cdd:PLN02479 191 PAdewqsiALGYTSGTTASPKGVVLHHRGAYLMALSNALIW-GMNEGAVyLWTLPMfhcNGWCF--------TWTLAAlC 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 284 VFVYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSR--YKFPHLHSCYTGGESLLPETLENWKAKtGLYIREF 361
Cdd:PLN02479 262 GTNICLRQVTAKAIYSAIANYGVTHFCAAPVVLNTIVNAPKSEtiLPLPRVVHVMTAGAAPPPSVLFAMSEK-GFRVTHT 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETgltcrisrtmtVKPGSLGTAVPHYDVQVIDEQGN------VLPPGKEGDIAIRVKPFRPI-------------- 421
Cdd:PLN02479 341 YGLSET-----------YGPSTVCAWKPEWDSLPPEEQARlnarqgVRYIGLEGLDVVDTKTMKPVpadgktmgeivmrg 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 422 -GIFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVI 500
Cdd:PLN02479 410 nMVMKGYLKNPKANEEAFANGWFHSGDLGVKHPDGYIEIKDRSKDIIISGGEN-----ISSLEVENVVYTHPAVLEASVV 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2025697431 501 SSPDPTRGEVVKAFVVLAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVlDLPKTITGKIERAKLRAK 572
Cdd:PLN02479 485 ARPDERWGESPCAFVTLKPGVDKSDEAALAEDIMKFCRERLPAYWVPKSVVFG-PLPKTATGKIQKHVLRAK 555
|
|
| PRK08308 |
PRK08308 |
acyl-CoA synthetase; Validated |
212-573 |
7.04e-28 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 115.90 E-value: 7.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 212 SHEPAAIYFTSGTSGLPKMAEHSHSSL---------GLKAKMDADSWTGLNVSDTVWTISDT------GWIVNILTSfle 276
Cdd:PRK08308 100 AEEPSLLQYSSGTTGEPKLIRRSWTEIdreieayneALNCEQDETPIVACPVTHSYGLICGVlaaltrGSKPVIITN--- 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 277 pwtlgacvfvyLLPKFdpqtVLKVLSSYPINSLVGAPLIYRMLLQqdLSRYKFpHLHSCYTGGeSLLPET-LENWKAKTg 355
Cdd:PRK08308 177 -----------KNPKF----ALNILRNTPQHILYAVPLMLHILGR--LLPGTF-QFHAVMTSG-TPLPEAwFYKLRERT- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 356 LYIREFYGQTETGltCrISRTMTVK-PGSLGTAVPHYDVQVIDEQGNvlpPGkegDIAIRVKPFRpigIFSGyvdnpkkt 434
Cdd:PRK08308 237 TYMMQQYGCSEAG--C-VSICPDMKsHLDLGNPLPHVSVSAGSDENA---PE---EIVVKMGDKE---IFTK-------- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 eanirgdfwllgDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAF 514
Cdd:PRK08308 297 ------------DLGYKSERGTLHFMGRMDDVINVSGL-----NVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKAK 359
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 515 VVLAPEFlshDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK08308 360 VISHEEI---DPVQLREWCIQHL----APYQVPHEIESVTEIPKNANGKVSRKLLELGE 411
|
|
| PLN02654 |
PLN02654 |
acetate-CoA ligase |
69-570 |
2.13e-27 |
|
acetate-CoA ligase
Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 116.92 E-value: 2.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 69 LWWMNGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYR 148
Cdd:PLN02654 109 YWEGNEPGFDASLTYSELLDRVCQLANYLKD-VGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQR 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 149 LQSSKARAIVAGDEVAQE---------VDAVAPDCSFLKIKL---LVSDN----RREG--WLNFKTLL-KDVSNTH--HC 207
Cdd:PLN02654 188 IVDCKPKVVITCNAVKRGpktinlkdiVDAALDESAKNGVSVgicLTYENqlamKREDtkWQEGRDVWwQDVVPNYptKC 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 208 -VE-TGSHEPAAIYFTSGTSGLPKMAEHS------HSSLGLKAKMDADSwtglnvSDTVWTISDTGWIVNILTSFLEPWT 279
Cdd:PLN02654 268 eVEwVDAEDPLFLLYTSGSTGKPKGVLHTtggymvYTATTFKYAFDYKP------TDVYWCTADCGWITGHSYVTYGPML 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 280 LGACVFVYL-LPKF-DPQTVLKVLSSYPINSLVGAPLIYRMLLQQD---LSRYKFPHLHSCYTGGESLLPETLE---NWK 351
Cdd:PLN02654 342 NGATVLVFEgAPNYpDSGRCWDIVDKYKVTIFYTAPTLVRSLMRDGdeyVTRHSRKSLRVLGSVGEPINPSAWRwffNVV 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 352 AKTGLYIREFYGQTETG--LTCRISRTMTVKPGSlgTAVPHYDVQ--VIDEQGNVLppgkEGDIA--IRVKPFRPiGIFS 425
Cdd:PLN02654 422 GDSRCPISDTWWQTETGgfMITPLPGAWPQKPGS--ATFPFFGVQpvIVDEKGKEI----EGECSgyLCVKKSWP-GAFR 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 426 GYVDNPKKTEANIRGDF---WLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISS 502
Cdd:PLN02654 495 TLYGDHERYETTYFKPFagyYFSGDGCSRDKDGYYWLTGRVDDVINVSG-----HRIGTAEVESALVSHPQCAEAAVVGI 569
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 503 PDPTRGEVVKAFVVLApEFLSHDpDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PLN02654 570 EHEVKGQGIYAFVTLV-EGVPYS-EELRKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILR 635
|
|
| LC_FACS_bac1 |
cd17641 |
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ... |
102-572 |
3.54e-27 |
|
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 115.98 E-value: 3.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 102 GLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEvaQEVDAV---APDCSFLK 178
Cdd:cd17641 32 GVGRGDVVAILGDNRPEWVWAELAAQAIGALSLGIYQDSMAEEVAYLLNYTGARVVIAEDE--EQVDKLleiADRIPSVR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 179 iKLLVSDNR-----REGWLNFKTLLKDVSNTHHCVETGSHEP----------AAIYFTSGTSGLPKMAEHSHSSLgLKAK 243
Cdd:cd17641 110 -YVIYCDPRgmrkyDDPRLISFEDVVALGRALDRRDPGLYERevaagkgedvAVLCTTSGTTGKPKLAMLSHGNF-LGHC 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 244 MDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACV-------------------FVYLLPK----FDPQTVLKV 300
Cdd:cd17641 188 AAYLAADPLGPGDEYVSVLPLPWIGEQMYSVGQALVCGFIVnfpeepetmmedlreigptFVLLPPRvwegIAADVRARM 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 301 LSSYPIN-------------------------------SLVGAPLIYRMLLqqdlSRYKFPHLHSCYTGGESLLPETLEN 349
Cdd:cd17641 268 MDATPFKrfmfelgmklglraldrgkrgrpvslwlrlaSWLADALLFRPLR----DRLGFSRLRSAATGGAALGPDTFRF 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 350 WKAkTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQvIDEQGNVLppgkegdiairvkpFRPIGIFSGYVD 429
Cdd:cd17641 344 FHA-IGVPLKQLYGQTELAGAYTVHRDGDVDPDTVGVPFPGTEVR-IDEVGEIL--------------VRSPGVFVGYYK 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 430 NPKKTEANIRGDFWLL-GDRGTKDPEGYFHFIGRTDDIINSS-GTSFcryriGPSEVENALMEHPAVAETVVISSPDPtr 507
Cdd:cd17641 408 NPEATAEDFDEDGWLHtGDAGYFKENGHLVVIDRAKDVGTTSdGTRF-----SPQFIENKLKFSPYIAEAVVLGAGRP-- 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 508 geVVKAFVVLAPEF-----------------LSHDPdQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPK---------TIT 561
Cdd:cd17641 481 --YLTAFICIDYAIvgkwaeqrgiafttytdLASRP-EVYELIRKEVEKVNASLPEAQRIRRFLLLYKeldaddgelTRT 557
|
570
....*....|.
gi 2025697431 562 GKIERAKLRAK 572
Cdd:cd17641 558 RKVRRGVIAEK 568
|
|
| PRK04813 |
PRK04813 |
D-alanine--poly(phosphoribitol) ligase subunit DltA; |
51-573 |
6.92e-27 |
|
D-alanine--poly(phosphoribitol) ligase subunit DltA;
Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 114.22 E-value: 6.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 51 VDHWANmekagKRPPRPALWWMngsGEELkwNFRELSEISQRAANVLSGpcgLQRGDRVAVVL--SQVPEWwLVT-LGCI 127
Cdd:PRK04813 8 IEEFAQ-----TQPDFPAYDYL---GEKL--TYGQLKEDSDALAAFIDS---LKLPDKSPIIVfgHMSPEM-LATfLGAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 128 RTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDavapdcsflKIKLLVSDNRREGWLNFKTLLKDvsnthHC 207
Cdd:PRK04813 74 KAGHAYIPVDVSSPAERIEMIIEVAKPSLIIATEELPLEIL---------GIPVITLDELKDIFATGNPYDFD-----HA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 208 VEtgSHEPAAIYFTSGTSGLPKMAEHSHSSLglkakmdadswtglnVSDTVWTISDTG------WIVNILTSF------L 275
Cdd:PRK04813 140 VK--GDDNYYIIFTSGTTGKPKGVQISHDNL---------------VSFTNWMLEDFAlpegpqFLNQAPYSFdlsvmdL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 276 EP-WTLGACVFVylLPK---FDPQTVLKVLSSYPINSLVGAPLIYRM-LLQQDLSRYKFPHLHSCYTGGESLLPETLENW 350
Cdd:PRK04813 203 YPtLASGGTLVA--LPKdmtANFKQLFETLPQLPINVWVSTPSFADMcLLDPSFNEEHLPNLTHFLFCGEELPHKTAKKL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 351 KAK-TGLYIREFYGQTET--GLT-CRISRTMTVKPGSL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIrvkpfrpIG-- 422
Cdd:PRK04813 281 LERfPSATIYNTYGPTEAtvAVTsIEITDEMLDQYKRLpiGYAKPDSPLLIIDEEGTKLPDGEQGEIVI-------SGps 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 423 IFSGYVDNPKKTEANirgdFWLL--------GDRGTKDpEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAV 494
Cdd:PRK04813 354 VSKGYLNNPEKTAEA----FFTFdgqpayhtGDAGYLE-DGLLFYQGRIDFQIKLNG-----YRIELEEIEQNLRQSSYV 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 495 AETVVIssPDPTRGEVVK--AFVVLAPEflSHDPD-QLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLrA 571
Cdd:PRK04813 424 ESAVVV--PYNKDHKVQYliAYVVPKEE--DFEREfELTKAIKKELKERLMEYMIPRKFIYRDSLPLTPNGKIDRKAL-I 498
|
..
gi 2025697431 572 KE 573
Cdd:PRK04813 499 EE 500
|
|
| PLN02574 |
PLN02574 |
4-coumarate--CoA ligase-like |
211-570 |
8.10e-27 |
|
4-coumarate--CoA ligase-like
Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 114.55 E-value: 8.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 211 GSHEPAAIYFTSGTSGLPKMAEHSH----SSLGLKAKMDADSWTGlNVSDTVWTISDTGWIVNILTSFLEPW-TLGACVF 285
Cdd:PLN02574 196 KQDDVAAIMYSSGTTGASKGVVLTHrnliAMVELFVRFEASQYEY-PGSDNVYLAALPMFHIYGLSLFVVGLlSLGSTIV 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 286 VylLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQ--QDLSRYKFPHLHSCYTGGESLLPETLENW-KAKTGLYIREFY 362
Cdd:PLN02574 275 V--MRRFDASDMVKVIDRFKVTHFPVVPPILMALTKkaKGVCGEVLKSLKQVSCGAAPLSGKFIQDFvQTLPHVDFIQGY 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTE-TGLTCRISRTMTVKP-GSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANIR 439
Cdd:PLN02574 353 GMTEsTAVGTRGFNTEKLSKySSVGLLAPNMQAKVVDwSTGCLLPPGNCGELWIQ-GP----GVMKGYLNNPKATQSTID 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 440 GDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLA 518
Cdd:PLN02574 428 KDGWLrTGDIAYFDEDGYLYIVDRLKEIIKYKG-----FQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRR 502
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 519 PEflshdpdqlTKLLQQ----HVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PLN02574 503 QG---------STLSQEavinYVAKQVAPYKKVRKVVFVQSIPKSPAGKILRRELK 549
|
|
| PRK06060 |
PRK06060 |
p-hydroxybenzoic acid--AMP ligase FadD22; |
102-572 |
1.15e-26 |
|
p-hydroxybenzoic acid--AMP ligase FadD22;
Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 114.74 E-value: 1.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 102 GLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVAqevDAVAPDcSFLKIKL 181
Cdd:PRK06060 51 GLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDALR---DRFQPS-RVAEAAE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 182 LVSDNRREGWLNFKTLLKDVSnthhcvetgshepAAIYFTSGTSGLPKMAEHSH-------------------SSLGL-K 241
Cdd:PRK06060 127 LMSEAARVAPGGYEPMGGDAL-------------AYATYTSGTTGPPKAAIHRHadpltfvdamcrkalrltpEDTGLcS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 242 AKMdadsWTGLNVSDTVWTISDTGWivnilTSFLEPWTLGACVFVYLLPKFDPQTVLKVLSSYPinSLVGApliyrmllq 321
Cdd:PRK06060 194 ARM----YFAYGLGNSVWFPLATGG-----SAVINSAPVTPEAAAILSARFGPSVLYGVPNFFA--RVIDS--------- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 322 qdLSRYKFPHLHSCYTGGESLLPETLENW-KAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQG 400
Cdd:PRK06060 254 --CSPDSFRSLRCVVSAGEALELGLAERLmEFFGGIPILDGIGSTEVGQTFVSNRVDEWRLGTLGRVLPPYEIRVVAPDG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 401 NVLPPGKEGDIAIRvKPfrpiGIFSGYVDNPKKTEANirGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIG 480
Cdd:PRK06060 332 TTAGPGVEGDLWVR-GP----AIAKGYWNRPDSPVAN--EGWLDTRDRVCIDSDGWVTYRCRADDTEVIGGVN-----VD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 481 PSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLA-PEFLshDPDQLTKLLQQHVKSVTApYKYPRKVEFVLDLPKT 559
Cdd:PRK06060 400 PREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATsGATI--DGSVMRDLHRGLLNRLSA-FKVPHRFAVVDRLPRT 476
|
490
....*....|...
gi 2025697431 560 ITGKIERAKLRAK 572
Cdd:PRK06060 477 PNGKLVRGALRKQ 489
|
|
| AAS_C |
cd05909 |
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ... |
207-571 |
1.28e-26 |
|
C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.
Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 113.58 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 207 CVETGSHEPAAIYFTSGTSGLPKMAEHSHSSL-----GLKAKMDADswtglnvsdtvwtisdTGWIV-NILTSF------ 274
Cdd:cd05909 141 VAPVQPDDPAVILFTSGSEGLPKGVVLSHKNLlanveQITAIFDPN----------------PEDVVfGALPFFhsfglt 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 275 ---LEPWTLGACVFVYLLPkFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQdLSRYKFPHLHSCYTGGESLLPETLENWK 351
Cdd:cd05909 205 gclWLPLLSGIKVVFHPNP-LDYKKIPELIYDKKATILLGTPTFLRGYARA-AHPEDFSSLRLVVAGAEKLKDTLRQEFQ 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 352 AKTGLYIREFYGQTETGLTCRISR-TMTVKPGSLGTAVPHYDVQVIDEQGNV-LPPGKEGDIAIRvkpfrpiG--IFSGY 427
Cdd:cd05909 283 EKFGIRILEGYGTTECSPVISVNTpQSPNKEGTVGRPLPGMEVKIVSVETHEeVPIGEGGLLLVR-------GpnVMLGY 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 428 VDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRtddiinssgtsFCRY-RIGP-----SEVENALMEH-PAVAETVVI 500
Cdd:cd05909 356 LNEPELTSFAFGDGWYDTGDIGKIDGEGFLTITGR-----------LSRFaKIAGemvslEAIEDILSEIlPEDNEVAVV 424
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2025697431 501 SSPDPTRGEVVKAFVVLapeflsHDPDQLTklLQQHVKSVTAPYKY-PRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:cd05909 425 SVPDGRKGEKIVLLTTT------TDTDPSS--LNDILKNAGISNLAkPSYIHQVEEIPLLGTGKPDYVTLKA 488
|
|
| LC_FACS_bac |
cd05932 |
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ... |
73-542 |
2.23e-26 |
|
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 112.95 E-value: 2.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 73 NGSGEELKWNfrELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSS 152
Cdd:cd05932 1 GGQVVEFTWG--EVADKARRLAAALRA-LGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 153 KARAIVAG--DEVAQEVDAVAPDCSFLKIKLLVSDNRREGWlnfKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKM 230
Cdd:cd05932 78 ESKALFVGklDDWKAMAPGVPEGLISISLPPPSAANCQYQW---DDLIAQHPPLEERPTRFPEQLATLIYTSGTTGQPKG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 231 AEHSHSSLGLKAKMDADSwTGLNVSD-----------TVWTISDTGWI--------VNILTSFLEPWTLGACVFVYLLP- 290
Cdd:cd05932 155 VMLTFGSFAWAAQAGIEH-IGTEENDrmlsylplahvTERVFVEGGSLyggvlvafAESLDTFVEDVQRARPTLFFSVPr 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 ---KFD-------PQTVLKVLSSYP-INSLVGAPLIYRMLLQQdlSRYKfphlhscyTGGESLLPETLENWKAKTGLYIR 359
Cdd:cd05932 234 lwtKFQqgvqdkiPQQKLNLLLKIPvVNSLVKRKVLKGLGLDQ--CRLA--------GCGSAPVPPALLEWYRSLGLNIL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 EFYGQTETGLTCRISRTMTVKPGSLGTAVPhyDVQV-IDEQGNVLppgkegdiairvkpFRPIGIFSGYVDNPKKTEANI 438
Cdd:cd05932 304 EAYGMTENFAYSHLNYPGRDKIGTVGNAGP--GVEVrISEDGEIL--------------VRSPALMMGYYKDPEATAEAF 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 439 RGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSFcryrIGPSEVENALMEHPAVAETVVISS--PDPTRGEVVKAFV 515
Cdd:cd05932 368 TADGFLrTGDKGELDADGNLTITGRVKDIFKTSKGKY----VAPAPIENKLAEHDRVEMVCVIGSglPAPLALVVLSEEA 443
|
490 500
....*....|....*....|....*..
gi 2025697431 516 VlaPEFLSHDPDQLTKLLQQHVKSVTA 542
Cdd:cd05932 444 R--LRADAFARAELEASLRAHLARVNS 468
|
|
| FACL_like_5 |
cd05924 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
218-563 |
6.61e-26 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 109.39 E-value: 6.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPK--MAEH--SHSSLGLKAKMDA-----DSWTGL---NVSDTVW-----TISDTGWivniLTSFLEPWTL 280
Cdd:cd05924 8 ILYTGGTTGMPKgvMWRQedIFRMLMGGADFGTgeftpSEDAHKaaaAAAGTVMfpappLMHGTGS----WTAFGGLLGG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 281 GACVFVYllPKFDPQTVLKVLSSYPINSL--VG----APLIYRMllqQDLSRYKFPHLHSCYTGGESLLPETLENW-KAK 353
Cdd:cd05924 84 QTVVLPD--DRFDPEEVWRTIEKHKVTSMtiVGdamaRPLIDAL---RDAGPYDLSSLFAISSGGALLSPEVKQGLlELV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 354 TGLYIREFYGQTETGLTcrisRTMTVKPGSLGTAV---PHYDVQVIDEQGNVLPPGKE--GDIAIRvkpfrpiG-IFSGY 427
Cdd:cd05924 159 PNITLVDAFGSSETGFT----GSGHSAGSGPETGPftrANPDTVVLDDDGRVVPPGSGgvGWIARR-------GhIPLGY 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 428 VDNPKKTEANIR---GDFW-LLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSP 503
Cdd:cd05924 228 YGDEAKTAETFPevdGVRYaVPGDRATVEADGTVTLLGRGSVCINTGGE-----KVFPEEVEEALKSHPAVYDVLVVGRP 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 504 DPTRGEVVKAFVVLAPeflSHDPDQltKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGK 563
Cdd:cd05924 303 DERWGQEVVAVVQLRE---GAGVDL--EELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
|
|
| PLN02860 |
PLN02860 |
o-succinylbenzoate-CoA ligase |
216-571 |
1.01e-25 |
|
o-succinylbenzoate-CoA ligase
Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 111.43 E-value: 1.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLGLK--AKMDAdswTGLNvSDTVWTisDTGWIVNI--LTSFLEPWTLGAC-VFvylLP 290
Cdd:PLN02860 175 VLICFTSGTTGRPKGVTISHSALIVQslAKIAI---VGYG-EDDVYL--HTAPLCHIggLSSALAMLMVGAChVL---LP 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 KFDPQTVLKVLSSYPINSLVGAPLIYRMLL---QQDLSRYKFPHLHSCYTGGESLLPETLENWK-----AKtglyIREFY 362
Cdd:PLN02860 246 KFDAKAALQAIKQHNVTSMITVPAMMADLIsltRKSMTWKVFPSVRKILNGGGSLSSRLLPDAKklfpnAK----LFSAY 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTETgltCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPP-----GKEG-DIAIRVKPFRPI---GIFS-------G 426
Cdd:PLN02860 322 GMTEA---CSSLTFMTLHDPTLESPKQTLQTVNQTKSSSVHQPqgvcvGKPApHVELKIGLDESSrvgRILTrgphvmlG 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 427 YVDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDP 505
Cdd:PLN02860 399 YWGQNSETASVLSNDGWLdTGDIGWIDKAGNLWLIGRSNDRIKTGGEN-----VYPEEVEAVLSQHPGVASVVVVGVPDS 473
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 506 TRGEVVKAFVVLAPEFL-SHDPDQLTK--------LLQQHV--KSVTApYKYPRKveFVL---DLPKTITGKIERAKLRA 571
Cdd:PLN02860 474 RLTEMVVACVRLRDGWIwSDNEKENAKknltlsseTLRHHCreKNLSR-FKIPKL--FVQwrkPFPLTTTGKIRRDEVRR 550
|
|
| PLN03102 |
PLN03102 |
acyl-activating enzyme; Provisional |
93-570 |
2.03e-25 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 110.49 E-value: 2.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 93 AANVLSgpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDE---VAQEVDA 169
Cdd:PLN03102 53 AASLIS--LNITKNDVVSVLAPNTPAMYEMHFAVPMAGAVLNPINTRLDATSIAAILRHAKPKILFVDRSfepLAREVLH 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 170 VAP-DCSFLKIKLLV------SDNRREGWLNFKTLLK------DVSNTHHCVETgSHEPAAIYFTSGTSGLPKMAEHSHS 236
Cdd:PLN03102 131 LLSsEDSNLNLPVIFiheidfPKRPSSEELDYECLIQrgeptpSLVARMFRIQD-EHDPISLNYTSGTTADPKGVVISHR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 237 SLGLKAKMDADSWTGLNVSDTVWTISD---TGWIVniltsflePWTLGA------CVFVYLLPKfdpqtVLKVLSSYPIN 307
Cdd:PLN03102 210 GAYLSTLSAIIGWEMGTCPVYLWTLPMfhcNGWTF--------TWGTAArggtsvCMRHVTAPE-----IYKNIEMHNVT 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 308 SLVGAPLIYRMLLQ---QDLSrYKFPHLHsCYTGGESLlPETLENWKAKTGLYIREFYGQTE-TG--LTCRI-------- 373
Cdd:PLN03102 277 HMCCVPTVFNILLKgnsLDLS-PRSGPVH-VLTGGSPP-PAALVKKVQRLGFQVMHAYGLTEaTGpvLFCEWqdewnrlp 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 374 -SRTMTVKP--GSLGTAVPHYDVQVIDEQGNVLPPGKE-GDIAIRVKpfrpiGIFSGYVDNPKKT-EANIRGdfWL-LGD 447
Cdd:PLN03102 354 eNQQMELKArqGVSILGLADVDVKNKETQESVPRDGKTmGEIVIKGS-----SIMKGYLKNPKATsEAFKHG--WLnTGD 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 448 RGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVL--APEFLSHD 525
Cdd:PLN03102 427 VGVIHPDGHVEIKDRSKDIIISGGEN-----ISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLekGETTKEDR 501
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 2025697431 526 PDQLT---KLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PLN03102 502 VDKLVtreRDLIEYCRENLPHFMCPRKVVFLQELPKNGNGKILKPKLR 549
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
60-569 |
2.77e-25 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 111.79 E-value: 2.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALwwmnGSGEElKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK12467 522 ARQHPERPAL----VFGEQ-VLSYAELNRQANRLAHVLIAA-GVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPE 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVAGDEVAQEVDaVAPDCSFLKIKLLVSdnrregwlnfktLLKDVSNTHHCVETGSHEPAAIY 219
Cdd:PRK12467 596 YPQDRLAYMLDDSGVRLLLTQSHLLAQLP-VPAGLRSLCLDEPAD------------LLCGYSGHNPEVALDPDNLAYVI 662
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 220 FTSGTSGLPKMAEHSHSSLGLKAKMDAdSWTGLNVSDTVWTISDTGWIVNILTSFlepWTLGACVFVYLLPK---FDPQT 296
Cdd:PRK12467 663 YTSGSTGQPKGVAISHGALANYVCVIA-ERLQLAADDSMLMVSTFAFDLGVTELF---GALASGATLHLLPPdcaRDAEA 738
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 297 VLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPhLHSCYTGGESLLPETLENWKAKT-GLYIREFYGQTETG---LTCR 372
Cdd:PRK12467 739 FAALMADQGVTVLKIVPSHLQALLQASRVALPRP-QRALVCGGEALQVDLLARVRALGpGARLINHYGPTETTvgvSTYE 817
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 373 ISRTMTVKPGS-LGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGD--------FW 443
Cdd:PRK12467 818 LSDEERDFGNVpIGQPLANLGLYILDHYLNPVPVGVVGELYIGGA-----GLARGYHRRPALTAERFVPDpfgadggrLY 892
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 444 LLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVkAFVVLAPEFLS 523
Cdd:PRK12467 893 RTGDLARYRADGVIEYLGRMDHQVKIRG-----FRIELGEIEARLLAQPGVREAVVLAQPGDAGLQLV-AYLVPAAVADG 966
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 2025697431 524 HDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK12467 967 AEHQATRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKAL 1012
|
|
| AMP-binding_C |
pfam13193 |
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ... |
483-563 |
4.53e-25 |
|
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.
Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 98.77 E-value: 4.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 483 EVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPeflshDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITG 562
Cdd:pfam13193 1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVLKP-----GVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSG 75
|
.
gi 2025697431 563 K 563
Cdd:pfam13193 76 K 76
|
|
| LC_FACL_like |
cd05914 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ... |
76-566 |
6.62e-25 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 107.91 E-value: 6.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 76 GEELKWNFRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKAR 155
Cdd:cd05914 3 YGGEPLTYKDLADNIAKFALLLK-INGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 156 AIVAGDEvaqevdavapdcsflkikllvsdnrregwlnfktllKDVsnthhcvetgshepAAIYFTSGTSGLPKMAEHSH 235
Cdd:cd05914 82 AIFVSDE------------------------------------DDV--------------ALINYTSGTTGNSKGVMLTY 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 236 SSLglKAKMDADSWTG-LNVSDTVWTISDTGWIVNILTSFLEPWTLGAcvFVYLLPKFdPQTVLKVLSSYPINSLVGAPL 314
Cdd:cd05914 112 RNI--VSNVDGVKEVVlLGKGDKILSILPLHHIYPLTFTLLLPLLNGA--HVVFLDKI-PSAKIIALAFAQVTPTLGVPV 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 315 IYRM--------LLQQDLSRYKFP------------------------HLHSCYTGGESLLPETLENWKaKTGLYIREFY 362
Cdd:cd05914 187 PLVIekifkmdiIPKLTLKKFKFKlakkinnrkirklafkkvheafggNIKEFVIGGAKINPDVEEFLR-TIGFPYTIGY 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQgnvlPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDF 442
Cdd:cd05914 266 GMTETAPIISYSPPNRIRLGSAGKVIDGVEVRIDSPD----PATGEGEIIVRGP-----NVMKGYYKNPEATAEAFDKDG 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 443 WL-LGDRGTKDPEGYFHFIGRTDD-IINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPtrgevVKAFVVLAPE 520
Cdd:cd05914 337 WFhTGDLGKIDAEGYLYIRGRKKEmIVLSSGKN-----IYPEEIEAKINNMPFVLESLVVVQEKK-----LVALAYIDPD 406
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 521 FLS----HDPDQLTKLLQQHVKSV---TAPYKYPRKVEFVL-DLPKTITGKIER 566
Cdd:cd05914 407 FLDvkalKQRNIIDAIKWEVRDKVnqkVPNYKKISKVKIVKeEFEKTPKGKIKR 460
|
|
| A_NRPS_Cytc1-like |
cd17643 |
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ... |
64-569 |
1.42e-24 |
|
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 106.62 E-value: 1.42e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALWWmngSGEELkwNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiqmkst 143
Cdd:cd17643 1 PEAVAVVD---EDRRL--TYGELDARANRLARTLRAE-GVGPGDRVALALPRSAELIVALLAILKAGGAYVP-------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 144 dilyrlqsskaraivagdevaqeVDAVAPDCsflKIKLLVSDNRregwlnFKTLLKDVSNthhcvetgshePAAIYFTSG 223
Cdd:cd17643 67 -----------------------IDPAYPVE---RIAFILADSG------PSLLLTDPDD-----------LAYVIYTSG 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 224 TSGLPK--MAEHSHSSLGLKAkmdADSWTGLNVSDtVWTIsdtgwivniLTSF------LEPW----TLGACVFVYLLPK 291
Cdd:cd17643 104 STGRPKgvVVSHANVLALFAA---TQRWFGFNEDD-VWTL---------FHSYafdfsvWEIWgallHGGRLVVVPYEVA 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 FDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPH-LHSCYTGGESLLPETLENWKAKTGLYIREF---YGQTET 367
Cdd:cd17643 171 RSPEDFARLLRDEGVTVLNQTPSAFYQLVEAADRDGRDPLaLRYVIFGGEALEAAMLRPWAGRFGLDRPQLvnmYGITET 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GL--TCRISRTMTVKPG---SLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfRPiGIFSGYVDNPKKT-EANIRGD 441
Cdd:cd17643 251 TVhvTFRPLDAADLPAAaasPIGRPLPGLRVYVLDADGRPVPPGVVGELYVS----GA-GVARGYLGRPELTaERFVANP 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 442 FWLLGDRG--TKD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAF 514
Cdd:cd17643 326 FGGPGSRMyrTGDlarrlPDGELEYLGRADEQVKIRG-----FRIELGEIEAALATHPSVRDAAVIVREDEPGDTRLVAY 400
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 515 VVLAPEflshdPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17643 401 VVADDG-----AAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450
|
|
| ttLC_FACS_like |
cd05915 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
78-570 |
4.33e-24 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 105.98 E-value: 4.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 78 ELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAI 157
Cdd:cd05915 22 VHRTTYAEVYQRARRLMGGLRA-LGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 VagdeVAQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLL-------KDVSNTHHCvetgshEPAAIYFTSGTSGLPKM 230
Cdd:cd05915 101 L----FDPNLLPLVEAIRGELKTVQHFVVMDEKAPEGYLAYeealgeeADPVRVPER------AACGMAYTTGTTGLPKG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 231 AEHSHSSLGLKAkmdadswTGLNVSDTVWTISDTGWIVNI----LTSFLEPWTLGAC--VFVYLLPKFDPQTVLKVLSSY 304
Cdd:cd05915 171 VVYSHRALVLHS-------LAASLVDGTALSEKDVVLPVVpmfhVNAWCLPYAATLVgaKQVLPGPRLDPASLVELFDGE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 305 PINSLVGAPLIYRMLLQ-QDLSRYKFPHLHSCYTGGESLlPETLENWKAKTGLYIREFYGQTET---GLTCRISRTMTVK 380
Cdd:cd05915 244 GVTFTAGVPTVWLALADyLESTGHRLKTLRRLVVGGSAA-PRSLIARFERMGVEVRQGYGLTETspvVVQNFVKSHLESL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 381 PGSLGTAVPHYD--------VQVIDEQGNVLP-PGKegdiAIRVKPFRPIGIFSGYVDNPKKTEAN-IRGDFWLLGDRGT 450
Cdd:cd05915 323 SEEEKLTLKAKTglpiplvrLRVADEEGRPVPkDGK----ALGEVQLKGPWITGGYYGNEEATRSAlTPDGFFRTGDIAV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 451 KDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLA-PEFLSHDPDQL 529
Cdd:cd05915 399 WDEEGYVEIKDRLKDLIKSGGEW-----ISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVPRgEKPTPEELNEH 473
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 2025697431 530 TKLLQQHVKSVtapykyPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05915 474 LLKAGFAKWQL------PDAYVFAEEIPRTSAGKFLKRALR 508
|
|
| A_NRPS_CmdD_like |
cd17652 |
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ... |
83-569 |
4.66e-24 |
|
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).
Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 105.03 E-value: 4.66e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPgtiqmkstdilyrlqsskaraivagde 162
Cdd:cd17652 15 YAELNARANRLARLLAA-RGVGPERLVALALPRSAELVVAILAVLKAGAAYLP--------------------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 163 vaqeVDavaPDCSFLKIKLLVSDNRRegwlnfktllkdvsnthHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLglkA 242
Cdd:cd17652 67 ----LD---PAYPAERIAYMLADARP-----------------ALLLTTPDNLAYVIYTSGSTGRPKGVVVTHRGL---A 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 243 KMDADSWTGLNVS--DTVWTISDTGWIVniltSFLEPW-TLGACVFVYLLPKFD---PQTVLKVLSSYPINSLVGAPLIY 316
Cdd:cd17652 120 NLAAAQIAAFDVGpgSRVLQFASPSFDA----SVWELLmALLAGATLVLAPAEEllpGEPLADLLREHRITHVTLPPAAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 317 RMLLQQDLsrykfPHLHSCYTGGESLLPETLENWkAKTglyiREF---YGQTETGLTCRISR---TMTVKPgsLGTAVPH 390
Cdd:cd17652 196 AALPPDDL-----PDLRTLVVAGEACPAELVDRW-APG----RRMinaYGPTETTVCATMAGplpGGGVPP--IGRPVPG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 391 YDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTE----ANIRGD----FWLLGDRGTKDPEGYFHFIGR 462
Cdd:cd17652 264 TRVYVLDARLRPVPPGVPGELYIA-----GAGLARGYLNRPGLTAerfvADPFGApgsrMYRTGDLARWRADGQLEFLGR 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 463 TDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPeflshDPDQLTKLLQQHVKSVTA 542
Cdd:cd17652 339 ADDQVKIRG-----FRIELGEVEAALTEHPGVAEAVVVVRDDRPGDKRLVAYVVPAP-----GAAPTAAELRAHLAERLP 408
|
490 500
....*....|....*....|....*...
gi 2025697431 543 PYKYPRKVeFVLD-LPKTITGKIERAKL 569
Cdd:cd17652 409 GYMVPAAF-VVLDaLPLTPNGKLDRRAL 435
|
|
| A_NRPS_TlmIV_like |
cd12114 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ... |
64-569 |
6.30e-23 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.
Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 101.96 E-value: 6.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 64 PPRPALwwMNGSGEelkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKST 143
Cdd:cd12114 1 PDATAV--ICGDGT---LTYGELAERARRVAGALKA-AGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 144 DILYRLQSSKARAIVAGDEVAQEVDAVAPDcsflkikLLVSDNRREGWLNFKTllkdvsnthhcVETGSHEPAAIYFTSG 223
Cdd:cd12114 75 RREAILADAGARLVLTDGPDAQLDVAVFDV-------LILDLDALAAPAPPPP-----------VDVAPDDLAYVIFTSG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 224 TSGLPKMAEHSHSSLglkakmdadswtgLNvsdtvwTISDTG--WIV----NILT----SF-LEPWTL-------GACVF 285
Cdd:cd12114 137 STGTPKGVMISHRAA-------------LN------TILDINrrFAVgpddRVLAlsslSFdLSVYDIfgalsagATLVL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 286 VYLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPH-----LHScytgGESL---LPETLenWKAKTGLY 357
Cdd:cd12114 198 PDEARRRDPAHWAELIERHGVTLWNSVPALLEMLLDVLEAAQALLPslrlvLLS----GDWIpldLPARL--RALAPDAR 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 358 IREFYGQTETGL---TCRISRTMT-VKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKK 433
Cdd:cd12114 272 LISLGGATEASIwsiYHPIDEVPPdWRSIPYGRPLANQRYRVLDPRGRDCPDWVPGELWIG-----GRGVALGYLGDPEL 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 434 TEA-----NIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTrG 508
Cdd:cd12114 347 TAArfvthPDGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVRG-----YRIELGEIEAALQAHPGVARAVVVVLGDPG-G 420
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 509 EVVKAFVVLAPEFLSHDPDQLTKLLQQHVKSvtapYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd12114 421 KRLAAFVVPDNDGTPIAPDALRAFLAQTLPA----YMIPSRVIALEALPLTANGKVDRAAL 477
|
|
| PRK13383 |
PRK13383 |
acyl-CoA synthetase; Provisional |
60-569 |
1.11e-22 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 101.61 E-value: 1.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWMNGSgeelkWNFRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQ 139
Cdd:PRK13383 45 AARWPGRTAIIDDDGA-----LSYRELQRATESLARRLT-RDGVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 140 MKSTDILYRLQSSKARAIVAGDEVAQEVdAVAPDcsflkiKLLVSDnrregwlnfktllkdvSNTHHCVETGSHEPAA-- 217
Cdd:PRK13383 119 FRSDALAAALRAHHISTVVADNEFAERI-AGADD------AVAVID----------------PATAGAEESGGRPAVAap 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 ---IYFTSGTSGLPKmaehshsslGLKAKMDADSWTGLNVSDTVWTISDTGWIVNILTSFLEPWTLGACVFVYLL----- 289
Cdd:PRK13383 176 griVLLTSGTTGKPK---------GVPRAPQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGMLMLTIALggtvl 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 --PKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQ---QDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQ 364
Cdd:PRK13383 247 thRHFDAEAALAQASLHRADAFTAVPVVLARILElppRVRARNPLPQLRVVMSSGDRLDPTLGQRFMDTYGDILYNGYGS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 365 TETGLTCRISRT-MTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPFRpigifSGYVDNPKKteANIRGdFW 443
Cdd:PRK13383 327 TEVGIGALATPAdLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAG-----TRYTDGGGK--AVVDG-MT 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 444 LLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEfLS 523
Cdd:PRK13383 399 STGDMGYLDNAGRLFIVGREDDMIISGGEN-----VYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPG-SG 472
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 2025697431 524 HDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK13383 473 VDAAQLRDYLKDRV----SRFEQPRDINIVSSIPRNPTGKVLRKEL 514
|
|
| A_NRPS_Sfm_like |
cd12115 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ... |
208-569 |
1.31e-22 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.
Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 100.85 E-value: 1.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 208 VETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGlkAKMDadsWTGLNVSDTVWT----ISDTGWIVNILTSFLePWTLGAC 283
Cdd:cd12115 100 VLTDPDDLAYVIYTSGSTGRPKGVAIEHRNAA--AFLQ---WAAAAFSAEELAgvlaSTSICFDLSVFELFG-PLATGGK 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 284 VFVyllpkfdPQTVLkVLSSYP-------INSLvgaPLIYRMLLQQDlsryKFPHLHSCYT-GGESLLPETLENWKAKTG 355
Cdd:cd12115 174 VVL-------ADNVL-ALPDLPaaaevtlINTV---PSAAAELLRHD----ALPASVRVVNlAGEPLPRDLVQRLYARLQ 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 356 LY-IREFYGQTE--TGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPK 432
Cdd:cd12115 239 VErVVNLYGPSEdtTYSTVAPVPPGASGEVSIGRPLANTQAYVLDRALQPVPLGVPGELYIG-----GAGVARGYLGRPG 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 433 KTEANIRGD-------FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDP 505
Cdd:cd12115 314 LTAERFLPDpfgpgarLYRTGDLVRWRPDGLLEFLGRADNQVKVRG-----FRIELGEIEAALRSIPGVREAVVVAIGDA 388
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 506 TRGEVVKAFVVLAPEFLShdpdqLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd12115 389 AGERRLVAYIVAEPGAAG-----LVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
|
|
| A_NRPS_SidN3_like |
cd05918 |
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ... |
53-571 |
1.77e-22 |
|
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 100.69 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 53 HWANMEKAGKRPPRPALW-WmNGSgeelkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPeWWLVT-LGCIRTG 130
Cdd:cd05918 2 HDLIEERARSQPDAPAVCaW-DGS-----LTYAELDRLSSRLAHHLRS-LGVGPGVFVPLCFEKSK-WAVVAmLAVLKAG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 131 LVFMPgtiqmksTDILY---RLQsskaraivagdEVAQEVDAvapdcsflkiKLLVSDNrregwlnfktllkdvsnthhc 207
Cdd:cd05918 74 GAFVP-------LDPSHplqRLQ-----------EILQDTGA----------KVVLTSS--------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 208 vetgSHEPAAIYFTSGTSGLPK--MAEHSHSSLGLKAKMDAdswTGLNVSDTV-------WTISdtgwIVNILTsflePW 278
Cdd:cd05918 105 ----PSDAAYVIFTSGSTGKPKgvVIEHRALSTSALAHGRA---LGLTSESRVlqfasytFDVS----ILEIFT----TL 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 279 TLGACVFVylLPKFD-PQTVLKVLSSYPINSLVGAPLIYRMLLQQDlsrykFPHLHSCYTGGESLLPETLENWKAKTGLY 357
Cdd:cd05918 170 AAGGCLCI--PSEEDrLNDLAGFINRLRVTWAFLTPSVARLLDPED-----VPSLRTLVLGGEALTQSDVDTWADRVRLI 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 358 IreFYGQTETGLTCRISR-TMTVKPGSLGTAVP---HydvqVIDEQGN--VLPPGKEGDIAIrvkpFRPIgIFSGYVDNP 431
Cdd:cd05918 243 N--AYGPAECTIAATVSPvVPSTDPRNIGRPLGatcW----VVDPDNHdrLVPIGAVGELLI----EGPI-LARGYLNDP 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 432 KKTEAN-IRGDFWLLGDRGTK-------------DPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAET 497
Cdd:cd05918 312 EKTAAAfIEDPAWLKQEGSGRgrrlyrtgdlvryNPDGSLEYVGRKDTQVKIRGQ-----RVELGEIEHHLRQSLPGAKE 386
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 498 VVISSPDPTRGEVVK---AFVVLAPEFLSHDPDQ------------LTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITG 562
Cdd:cd05918 387 VVVEVVKPKDGSSSPqlvAFVVLDGSSSGSGDGDslflepsdefraLVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASG 466
|
....*....
gi 2025697431 563 KIERAKLRA 571
Cdd:cd05918 467 KIDRRALRE 475
|
|
| PRK07008 |
PRK07008 |
long-chain-fatty-acid--CoA ligase; Validated |
220-570 |
2.67e-22 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 100.55 E-value: 2.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 220 FTSGTSGLPKMAEHSHSSLGLKAKMDA--DSwTGLNVSDTV-----------WTISDTGwivniltsflepwTLGACVFV 286
Cdd:PRK07008 183 YTSGTTGNPKGALYSHRSTVLHAYGAAlpDA-MGLSARDAVlpvvpmfhvnaWGLPYSA-------------PLTGAKLV 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 YLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQT 365
Cdd:PRK07008 249 LPGPDLDGKSLYELIEAERVTFSAGVPTVWLGLLNHmREAGLRFSTLRRTVIGGSACPPAMIRTFEDEYGVEVIHAWGMT 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 366 ET---GLTCRISRTMTVKPGSL--------GTAVPHYDVQVIDEQGNVLP-PGKE-GDIAIRvKPFrpigIFSGYVdnpk 432
Cdd:PRK07008 329 EMsplGTLCKLKWKHSQLPLDEqrkllekqGRVIYGVDMKIVGDDGRELPwDGKAfGDLQVR-GPW----VIDRYF---- 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 433 KTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVV 511
Cdd:PRK07008 400 RGDASPLVDGWFpTGDVATIDADGFMQITDRSKDVIKSGGE-----WISSIDIENVAVAHPAVAEAACIACAHPKWDERP 474
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 512 KAFVVLAPEFlshdpdQLTK-LLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK07008 475 LLVVVKRPGA------EVTReELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLR 528
|
|
| PRK05620 |
PRK05620 |
long-chain fatty-acid--CoA ligase; |
87-571 |
5.80e-22 |
|
long-chain fatty-acid--CoA ligase;
Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 99.86 E-value: 5.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 87 SEISQRAA---NVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEV 163
Cdd:PRK05620 42 AAIGARAAalaHALHDELGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEVIVADPRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 164 AQEVDAVAPDCSFLKIKLLVSDN--------RREGW--LNFKTLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEH 233
Cdd:PRK05620 122 AEQLGEILKECPCVRAVVFIGPSdadsaaahMPEGIkvYSYEALLDGRSTVYDWPELDETTAAAICYSTGTTGAPKGVVY 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 234 SHSSLGLKAkmdadswTGLNVSDTVWTISDTGW-----IVNILtSFLEP---WTLGACVfVYLLPKFDPQTVLKVLSSYP 305
Cdd:PRK05620 202 SHRSLYLQS-------LSLRTTDSLAVTHGESFlccvpIYHVL-SWGVPlaaFMSGTPL-VFPGPDLSAPTLAKIIATAM 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 306 INSLVGAPLIYRMLLQQDLSRY-KFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTvkpGSL 384
Cdd:PRK05620 273 PRVAHGVPTLWIQLMVHYLKNPpERMSLQEIYVGGSAVPPILIKAWEERYGVDVVHVWGMTETSPVGTVARPPS---GVS 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 385 GTAVPHYDV-----------QVIDEqGNVLPPG--KEGDIAIRvkpfrpiG--IFSGYVDNPKKTE----ANIRG----- 440
Cdd:PRK05620 350 GEARWAYRVsqgrfpasleyRIVND-GQVMESTdrNEGEIQVR-------GnwVTASYYHSPTEEGggaaSTFRGedved 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 441 -------DFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVK 512
Cdd:PRK05620 422 andrftaDGWLrTGDVGSVTRDGFLTIHDRARDVIRSGGE-----WIYSAQLENYIMAAPEVVECAVIGYPDDKWGERPL 496
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 513 AFVVLAP--EFLSHDPDQLTKLLQQHVKSVTAPYKYprkvEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK05620 497 AVTVLAPgiEPTRETAERLRDQLRDRLPNWMLPEYW----TFVDEIDKTSVGKFDKKDLRQ 553
|
|
| LC_FACS_like |
cd17640 |
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ... |
80-538 |
5.81e-22 |
|
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 98.97 E-value: 5.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVa 159
Cdd:cd17640 5 RITYKDLYQEILDFAAGLRS-LGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVALV- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 160 gdevaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcVETGSHEPAAIYFTSGTSGLPKMAEHSHSSLg 239
Cdd:cd17640 83 ------------------------------------------------VENDSDDLATIIYTSGTTGNPKGVMLTHANL- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 240 lkakmdadswtglnvsdtVWTISDTGWIV-----NILTSFLEPW-----------TLGACVFVYLLPKFDPQTVLKVLSS 303
Cdd:cd17640 114 ------------------LHQIRSLSDIVppqpgDRFLSILPIWhsyersaeyfiFACGCSQAYTSIRTLKDDLKRVKPH 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 304 YpinsLVGAPLIY------------------RMLLQQDLS--RYKFPhlhscYTGGESLLPETLENWKAkTGLYIREFYG 363
Cdd:cd17640 176 Y----IVSVPRLWeslysgiqkqvsksspikQFLFLFFLSggIFKFG-----ISGGGALPPHVDTFFEA-IGIEVLNGYG 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 364 QTETG--LTCRISRTMTVkpGSLGTAVPHYDVQVIDEQGN-VLPPGKEGDIAIRVKPfrpigIFSGYVDNPKKTEANIRG 440
Cdd:cd17640 246 LTETSpvVSARRLKCNVR--GSVGRPLPGTEIKIVDPEGNvVLPPGEKGIVWVRGPQ-----VMKGYYKNPEATSKVLDS 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 441 DFWL-LGDRGTKDPEGYFHFIGRTDD-IINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRG-------EVV 511
Cdd:cd17640 319 DGWFnTGDLGWLTCGGELVLTGRAKDtIVLSNGEN-----VEPQPIEEALMRSPFIEQIMVVGQDQKRLGalivpnfEEL 393
|
490 500 510
....*....|....*....|....*....|...
gi 2025697431 512 KAFVVLAPEFLSHDPDQL------TKLLQQHVK 538
Cdd:cd17640 394 EKWAKESGVKLANDRSQLlaskkvLKLYKNEIK 426
|
|
| PRK13388 |
PRK13388 |
acyl-CoA synthetase; Provisional |
77-576 |
7.25e-22 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 99.33 E-value: 7.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 77 EELKWNFRE-LSEISQRAANVLSgpcgLQRGDR---VAVVLSQVPEWWLVTLGCIRTGLVFmpgtIQMKST--------D 144
Cdd:PRK13388 23 GDRTWTWREvLAEAAARAAALIA----LADPDRplhVGVLLGNTPEMLFWLAAAALGGYVL----VGLNTTrrgaalaaD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 145 ILYrlqsSKARAIVAGDEVAQEVDAVA-PDCSFLkiklLVSDNRregwlnFKTLLKDVSNTHHCVETGSHEPAAIYFTSG 223
Cdd:PRK13388 95 IRR----ADCQLLVTDAEHRPLLDGLDlPGVRVL----DVDTPA------YAELVAAAGALTPHREVDAMDPFMLIFTSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 224 TSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVWTISD--------TGWIVnILTSflepwtlGACVfvYLLPKFDPQ 295
Cdd:PRK13388 161 TTGAPKAVRCSHGRLAFAGRALTERF-GLTRDDVCYVSMPlfhsnavmAGWAP-AVAS-------GAAV--ALPAKFSAS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 296 TVLKVLSSYPINSL--VGAPLIYRMLL------QQDLSRYKFphlhscytGGESLlPETLENWKAKTGLYIREFYGQTET 367
Cdd:PRK13388 230 GFLDDVRRYGATYFnyVGKPLAYILATperpddADNPLRVAF--------GNEAS-PRDIAEFSRRFGCQVEDGYGSSEG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 GltCRISRTMTVKPGSLGTAVPH---YD--------VQVIDEQGNVLPPGKE-GDIAIRVKPfrpiGIFSGYVDNPKKTE 435
Cdd:PRK13388 301 A--VIVVREPGTPPGSIGRGAPGvaiYNpetltecaVARFDAHGALLNADEAiGELVNTAGA----GFFEGYYNNPEATA 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 436 ANIR-GDFWLlGDRGTKDPEGYFHFIGRTDDIINSSGTSFcryriGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAF 514
Cdd:PRK13388 375 ERMRhGMYWS-GDLAYRDADGWIYFAGRTADWMRVDGENL-----SAAPIERILLRHPAINRVAVYAVPDERVGDQVMAA 448
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2025697431 515 VVLAPEfLSHDPDQLTKLLqqHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKT 576
Cdd:PRK13388 449 LVLRDG-ATFDPDAFAAFL--AAQPDLGTKAWPRYVRIAADLPSTATNKVLKRELIAQGWAT 507
|
|
| A_NRPS_TubE_like |
cd05906 |
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ... |
75-571 |
1.36e-21 |
|
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 98.51 E-value: 1.36e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 75 SGEELKWNFRELSEISQRAANVLsGPCGLQRGDRVAVVLSQ----VPEWWlvtlGCIRTGLVFMPGTIQMKstdilYRLQ 150
Cdd:cd05906 34 DGSEEFQSYQDLLEDARRLAAGL-RQLGLRPGDSVILQFDDnedfIPAFW----ACVLAGFVPAPLTVPPT-----YDEP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 151 SSKAR------------AIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNrregwlnfktlLKDVSNTHHCVETGSHEPAAI 218
Cdd:cd05906 104 NARLRklrhiwqllgspVVLTDAELVAEFAGLETLSGLPGIRVLSIEE-----------LLDTAADHDLPQSRPDDLALL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 219 YFTSGTSGLPKMAEHSHSSLglKAKMDADSWTGLNVSDTV---WTISDTgwIVNILTSFLEPWTLGA----CVFVYLLPk 291
Cdd:cd05906 173 MLTSGSTGFPKAVPLTHRNI--LARSAGKIQHNGLTPQDVflnWVPLDH--VGGLVELHLRAVYLGCqqvhVPTEEILA- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 fDPQTVLKVLSSYPInSLVGAP-LIYRMLLQQ---------DLSRYKFphlhsCYTGGESLLPETLENWK---AKTGL-- 356
Cdd:cd05906 248 -DPLRWLDLIDRYRV-TITWAPnFAFALLNDLleeiedgtwDLSSLRY-----LVNAGEAVVAKTIRRLLrllEPYGLpp 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 357 -YIREFYGQTET--GLT-CRISRTMTVKPG----SLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKPfrpigIFSGYV 428
Cdd:cd05906 321 dAIRPAFGMTETcsGVIySRSFPTYDHSQAlefvSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPV-----VTKGYY 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 429 DNPKKTEANIRGDFWL-LGDRGTKDpEGYFHFIGRTDDIINSSGTSFcryriGPSEVENALMEHPAVAE--TVVISSPDP 505
Cdd:cd05906 396 NNPEANAEAFTEDGWFrTGDLGFLD-NGNLTITGRTKDTIIVNGVNY-----YSHEIEAAVEEVPGVEPsfTAAFAVRDP 469
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 506 TRGEVVKAfVVLAPEF-LSHDPDQLTKLLQQHVK---SVTAPYKYPRKVEfvlDLPKTITGKIERAKLRA 571
Cdd:cd05906 470 GAETEELA-IFFVPEYdLQDALSETLRAIRSVVSrevGVSPAYLIPLPKE---EIPKTSLGKIQRSKLKA 535
|
|
| A_NRPS_ProA |
cd17656 |
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ... |
77-569 |
2.67e-21 |
|
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 97.16 E-value: 2.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 77 EELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARA 156
Cdd:cd17656 10 ENQKLTYRELNERSNQLARFLREK-GVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIMLDSGVRV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 157 IVAGDEVAQEVdavapdcSFLKIKLLVSDNrregwlnfktLLKDVSNTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHS 236
Cdd:cd17656 89 VLTQRHLKSKL-------SFNKSTILLEDP----------SISQEDTSNIDYINNSDDLLYIIYTSGTTGKPKGVQLEHK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 237 SLGLKAKMDADsWTGLNVSDTVWTISDTGWIV---NILTSFLEPWTLgacvfvYLLP---KFDPQTVLKVLSSYPINSLV 310
Cdd:cd17656 152 NMVNLLHFERE-KTNINFSDKVLQFATCSFDVcyqEIFSTLLSGGTL------YIIReetKRDVEQLFDLVKRHNIEVVF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 311 GAPLIYRMLLQQDLSRYKFPH-LHSCYTGGESL-LPETLENWKAKTGLYIREFYGQTETGLTCrisrTMTVKPGS----- 383
Cdd:cd17656 225 LPVAFLKFIFSEREFINRFPTcVKHIITAGEQLvITNEFKEMLHEHNVHLHNHYGPSETHVVT----TYTINPEAeipel 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 384 --LGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKT---------EANIRgdFWLLGDRGTKD 452
Cdd:cd17656 301 ppIGKPISNTWIYILDQEQQLQPQGIVGELYIS-----GASVARGYLNRQELTaekffpdpfDPNER--MYRTGDLARYL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 453 PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlshDPDQLTKL 532
Cdd:cd17656 374 PDGNIEFLGRADHQVKIRG-----YRIELGEIEAQLLNHPGVSEAVVLDKADDKGEKYLCAYFVMEQEL---NISQLREY 445
|
490 500 510
....*....|....*....|....*....|....*..
gi 2025697431 533 LQQHVKSvtapYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17656 446 LAKQLPE----YMIPSFFVPLDQLPLTPNGKVDRKAL 478
|
|
| PTZ00237 |
PTZ00237 |
acetyl-CoA synthetase; Provisional |
212-566 |
5.20e-21 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 97.12 E-value: 5.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 212 SHEPAAIYFTSGTSGLPKMAEHSHSS--LGLKAkmdadSWTGLNVSD---TVWTISDTGWIVniLTSFLEPWTLGACVFV 286
Cdd:PTZ00237 253 SSHPLYILYTSGTTGNSKAVVRSNGPhlVGLKY-----YWRSIIEKDiptVVFSHSSIGWVS--FHGFLYGSLSLGNTFV 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 -----YLLPKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQD------LSRYKFPHLHSCYTGGESL---LPETLENwka 352
Cdd:PTZ00237 326 mfeggIIKNKHIEDDLWNTIEKHKVTHTLTLPKTIRYLIKTDpeatiiRSKYDLSNLKEIWCGGEVIeesIPEYIEN--- 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 353 KTGLYIREFYGQTETGLTCRISRTMTVKP-GSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVkPFRPiGIFSGYVDNP 431
Cdd:PTZ00237 403 KLKIKSSRGYGQTEIGITYLYCYGHINIPyNATGVPSIFIKPSILSEDGKELNVNEIGEVAFKL-PMPP-SFATTFYKND 480
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 432 ---KKTEANIRGdFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRG 508
Cdd:PTZ00237 481 ekfKQLFSKFPG-YYNSGDLGFKDENGYYTIVSRSDDQIKISGNK-----VQLNTIETSILKHPLVLECCSIGIYDPDCY 554
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 509 EVVKAFVVLAPEFLSH--DPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIER 566
Cdd:PTZ00237 555 NVPIGLLVLKQDQSNQsiDLNKLKNEINNIITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
|
|
| PRK05857 |
PRK05857 |
fatty acid--CoA ligase; |
57-571 |
1.37e-20 |
|
fatty acid--CoA ligase;
Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 95.46 E-value: 1.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 57 MEKAGKRPPRPALWWMNGSGEelkWNFREL-SEISQRAANVLSGpcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMP 135
Cdd:PRK05857 21 FEQARQQPEAIALRRCDGTSA---LRYRELvAEVGGLAADLRAQ--SVSRGSRVLVISDNGPETYLSVLACAKLGAIAVM 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 136 GTIQMKSTDILYRLQSSKARAIVAGDEvaQEVDAVAPDCSFLKIKLLVSDNRREGWLNFKTLLKDVSNTHhcVETGSHEP 215
Cdd:PRK05857 96 ADGNLPIAAIERFCQITDPAAALVAPG--SKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGN--ADQGSEDP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPK---MAEHSHSSLGLKAKMDADSWTGLNVSDTVWT------ISDTGWIVNILTSFlepwtlGACVfv 286
Cdd:PRK05857 172 LAMIFTSGTTGEPKavlLANRTFFAVPDILQKEGLNWVTWVVGETTYSplpathIGGLWWILTCLMHG------GLCV-- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 ylLPKFDPQTVLKVLSSYPINSLVGAP-LIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAkTGLYIREFYGQT 365
Cdd:PRK05857 244 --TGGENTTSLLEILTTNAVATTCLVPtLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEA-TGVRTAQVYGLS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 366 ETGLTC--------RISRtmtVKPGSLGTAVPHYDVQVIDEQG------NVLPPGKEGDIAIRvkpfRPIGIFsGYVDNP 431
Cdd:PRK05857 321 ETGCTAlclptddgSIVK---IEAGAVGRPYPGVDVYLAATDGigptapGAGPSASFGTLWIK----SPANML-GYWNNP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 432 KKTEaNIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:PRK05857 393 ERTA-EVLIDGWVnTGDLLERREDGFFYIKGRSSEMIICGGVN-----IAPDEVDRIAEGVSGVREAACYEIPDEEFGAL 466
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 511 VKAFVVLAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK05857 467 VGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAA 527
|
|
| entE |
PRK10946 |
(2,3-dihydroxybenzoyl)adenylate synthase; |
392-571 |
3.09e-20 |
|
(2,3-dihydroxybenzoyl)adenylate synthase;
Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 94.29 E-value: 3.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 392 DVQVIDEQGNVLPPGKEGDIAIRvKPFrpigIFSGYVDNPkktEANIRG----DFWLLGDRGTKDPEGYFHFIGRTDDII 467
Cdd:PRK10946 364 EVWVADADGNPLPQGEVGRLMTR-GPY----TFRGYYKSP---QHNASAfdanGFYCSGDLVSIDPDGYITVVGREKDQI 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 468 NSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlshDPDQLTK-LLQQHVksvtAPYKY 546
Cdd:PRK10946 436 NRGGE-----KIAAEEIENLLLRHPAVIHAALVSMEDELMGEKSCAFLVVKEPL---KAVQLRRfLREQGI----AEFKL 503
|
170 180
....*....|....*....|....*
gi 2025697431 547 PRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK10946 504 PDRVECVDSLPLTAVGKVDKKQLRQ 528
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
216-569 |
3.66e-20 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 95.41 E-value: 3.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVWTISDTGWIVNILTSFLePWTLGACVFVYLLPKF-DP 294
Cdd:PRK12316 3199 AYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAY-GLGVGDRVLQFTTFSFDVFVEELFW-PLMSGARVVLAGPEDWrDP 3276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 295 QTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRyKFPHLHSCYTGGESLLPETLENWKAKTGLYirEFYGQTETGLTCRIS 374
Cdd:PRK12316 3277 ALLVELINSEGVDVLHAYPSMLQAFLEEEDAH-RCTSLKRIVCGGEALPADLQQQVFAGLPLY--NLYGPTEATITVTHW 3353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 375 RTMTVKPGSL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANIRGDFWLLGDR--GT 450
Cdd:PRK12316 3354 QCVEEGKDAVpiGRPIANRACYILDGSLEPVPVGALGELYLG-----GEGLARGYHNRPGLTAERFVPDPFVPGERlyRT 3428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 451 KD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISspdpTRGEVVKAFVVlapefLSHD 525
Cdd:PRK12316 3429 GDlaryrADGVIEYIGRVDHQVKIRG-----FRIELGEIEARLLEHPWVREAVVLA----VDGRQLVAYVV-----PEDE 3494
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2025697431 526 PDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK12316 3495 AGDLREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKAL 3538
|
|
| A_NRPS_LgrA-like |
cd17645 |
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ... |
58-569 |
3.66e-20 |
|
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.
Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 93.39 E-value: 3.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsgEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:cd17645 6 EQVERTPDHVAVVD-----RGQSLTYKQLNEKANQLARHLRG-KGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPID 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKAraivagdevaqevdavapdcsflkikllvsdnrregwlnfKTLLKDVSNThhcvetgshepAA 217
Cdd:cd17645 80 PDYPGERIAYMLADSSA----------------------------------------KILLTNPDDL-----------AY 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPK--MAEHS---------HSSLGLKAKMDADSWTGLNVSDTVWTISDTgwivniltsflepWTLGACVFV 286
Cdd:cd17645 109 VIYTSGSTGLPKgvMIEHHnlvnlcewhRPYFGVTPADKSLVYASFSFDASAWEIFPH-------------LTAGAALHV 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 ylLP---KFDPQTVLKVLSSYPIN-SLVGAPLIYRMLLQQDLSrykfphLHSCYTGGESLlpetleNWKAKTGLYIREFY 362
Cdd:cd17645 176 --VPserRLDLDALNDYFNQEGITiSFLPTGAAEQFMQLDNQS------LRVLLTGGDKL------KKIERKGYKLVNNY 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTEtgltCRISRTM-TVKPG----SLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEAN 437
Cdd:cd17645 242 GPTE----NTVVATSfEIDKPyaniPIGKPIDNTRVYILDEALQLQPIGVAGELCIAGE-----GLARGYLNRPELTAEK 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGD-------FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:cd17645 313 FIVHpfvpgerMYRTGDLAKFLPDGNIEFLGRLDQQVKIRG-----YRIEPGEIEPFLMNHPLIELAAVLAKEDADGRKY 387
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 511 VKAFVVlAPEFLSHDPdqltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17645 388 LVAYVT-APEEIPHEE------LREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
58-573 |
4.12e-20 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 95.23 E-value: 4.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngSGEELkwNFRELSEISQRAANVLsgpcgLQRG----DRVAVVLSQVPEWWLVTLGCIRTGLVF 133
Cdd:PRK12467 1582 DQAAATPEAVALVF---GEQEL--TYGELNRRANRLAHRL-----IALGvgpeVLVGIAVERSLEMVVGLLAILKAGGAY 1651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 134 MPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVApdcsflKIKLLVSDNRREgWLNFKtllkdvSNTHHCVETGSH 213
Cdd:PRK12467 1652 VPLDPEYPRERLAYMIEDSGIELLLTQSHLQARLPLPD------GLRSLVLDQEDD-WLEGY------SDSNPAVNLAPQ 1718
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLglKAKMDA-DSWTGLNVSDTVWTISDTGWIVNILTSFlepWTL---GACVFVYLL 289
Cdd:PRK12467 1719 NLAYVIYTSGSTGRPKGAGNRHGAL--VNRLCAtQEAYQLSAADVVLQFTSFAFDVSVWELF---WPLingARLVIAPPG 1793
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAK---TGLYirEFYGQTE 366
Cdd:PRK12467 1794 AHRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQVEHPLSLRRVVCGGEALEVEALRPWLERlpdTGLF--NLYGPTE 1871
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 367 TGL-----TCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTE------ 435
Cdd:PRK12467 1872 TAVdvthwTCRRKDLEGRDSVPIGQPIANLSTYILDASLNPVPIGVAGELYLG-----GVGLARGYLNRPALTAerfvad 1946
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 436 --ANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKA 513
Cdd:PRK12467 1947 pfGTVGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRG-----FRIELGEIEARLREQGGVREAVVIAQDGANGKQLVAY 2021
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2025697431 514 FVVLAPEFLSHDPDQLT--KLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK12467 2022 VVPTDPGLVDDDEAQVAlrAILKNHLKASLPEYMVPAHLVFLARMPLTPNGKLDRKALPAPD 2083
|
|
| PRK06018 |
PRK06018 |
putative acyl-CoA synthetase; Provisional |
216-570 |
5.01e-20 |
|
putative acyl-CoA synthetase; Provisional
Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 93.66 E-value: 5.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLGLKAKM--DADSwTGLNVSDTVWTI----SDTGWIVniltSFLEPwTLGACVfVYLL 289
Cdd:PRK06018 180 AGMCYTSGTTGDPKGVLYSHRSNVLHALManNGDA-LGTSAADTMLPVvplfHANSWGI----AFSAP-SMGTKL-VMPG 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQ-DLSRYKFPHLHSCYTGGeSLLPETLENWKAKTGLYIREFYGQTET- 367
Cdd:PRK06018 253 AKLDGASVYELLDTEKVTFTAGVPTVWLMLLQYmEKEGLKLPHLKMVVCGG-SAMPRSMIKAFEDMGVEVRHAWGMTEMs 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 --GLTCRISRTMTVKPGS------LGTAVPHYDVQ--VIDEQGNVLPpgKEGDIAIRVKPFRPIgIFSGYVdnpkKTEAN 437
Cdd:PRK06018 332 plGTLAALKPPFSKLPGDarldvlQKQGYPPFGVEmkITDDAGKELP--WDGKTFGRLKVRGPA-VAAAYY----RVDGE 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGD--FWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFV 515
Cdd:PRK06018 405 ILDDdgFFDTGDVATIDAYGYMRITDRSKDVIKSGGE-----WISSIDLENLAVGHPKVAEAAVIGVYHPKWDERPLLIV 479
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2025697431 516 VLAPEfLSHDPDQLTKLLQQHVksvtAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK06018 480 QLKPG-ETATREEILKYMDGKI----AKWWMPDDVAFVDAIPHTATGKILKTALR 529
|
|
| A_NRPS_ApnA-like |
cd17644 |
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ... |
210-569 |
2.86e-19 |
|
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 90.96 E-value: 2.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 210 TGSHEPAAIYFTSGTSGLPK--MAEHS---HSSLGLKAKMDADS--WTGLNVSdtvwtISDTGWIVNILTSFLEPWTLga 282
Cdd:cd17644 103 TQPENLAYVIYTSGSTGKPKgvMIEHQslvNLSHGLIKEYGITSsdRVLQFAS-----IAFDVAAEEIYVTLLSGATL-- 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 cvfvYLLPK---FDPQTVLKVLSSYPINSLvGAPLIYRMLLQQDLSRYKFP---HLHSCYTGGESLLPETLENWKAKTGL 356
Cdd:cd17644 176 ----VLRPEemrSSLEDFVQYIQQWQLTVL-SLPPAYWHLLVLELLLSTIDlpsSLRLVIVGGEAVQPELVRQWQKNVGN 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 357 YIR--EFYGQTETGLT---CRISRTMTVKPGS--LGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVD 429
Cdd:cd17644 251 FIQliNVYGPTEATIAatvCRLTQLTERNITSvpIGRPIANTQVYILDENLQPVPVGVPGELHIG-----GVGLARGYLN 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 430 NPKKT-EANIRGDF--------WLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVI 500
Cdd:cd17644 326 RPELTaEKFISHPFnsseserlYKTGDLARYLPDGNIEYLGRIDNQVKIRG-----FRIELGEIEAVLSQHNDVKTAVVI 400
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 501 SSPDPTRGEVVKAFVVlaPEFlshDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17644 401 VREDQPGNKRLVAYIV--PHY---EESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKIDRRAL 464
|
|
| PRK08279 |
PRK08279 |
long-chain-acyl-CoA synthetase; Validated |
49-553 |
5.80e-19 |
|
long-chain-acyl-CoA synthetase; Validated
Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 90.70 E-value: 5.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 49 DVVDHWANmekagKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIR 128
Cdd:PRK08279 41 DVFEEAAA-----RHPDRPAL-----LFEDQSISYAELNARANRYAHWAAAR-GVGKGDVVALLMENRPEYLAAWLGLAK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 129 TGLVF-MPGTIQMKstDIL-YRLQSSKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSDNR---REGWLNFKTLLKDVSn 203
Cdd:PRK08279 110 LGAVVaLLNTQQRG--AVLaHSLNLVDAKHLIVGEELVEAFEEARADLARPPRLWVAGGDTlddPEGYEDLAAAAAGAP- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 204 THHCVETGS---HEPAAIYFTSGTSGLPKMAEHSH-------SSLGLKAKMDADSW----------TGLNVsdtVW--TI 261
Cdd:PRK08279 187 TTNPASRSGvtaKDTAFYIYTSGTTGLPKAAVMSHmrwlkamGGFGGLLRLTPDDVlycclplyhnTGGTV---AWssVL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 262 SDTGWIVnI-----LTSFlepW----TLGACVFVYllpkfdpqtvlkvlssypinslVGAplIYRMLLQQDLSRYKFPHL 332
Cdd:PRK08279 264 AAGATLA-LrrkfsASRF---WddvrRYRATAFQY----------------------IGE--LCRYLLNQPPKPTDRDHR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 333 HSCYTG-GesLLPETLENWKAKTGL-YIREFYGQTE--TGL--------TCRISRTMTVKPGslgtAVPHYDVQ----VI 396
Cdd:PRK08279 316 LRLMIGnG--LRPDIWDEFQQRFGIpRILEFYAASEgnVGFinvfnfdgTVGRVPLWLAHPY----AIVKYDVDtgepVR 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 397 DEQGNVLP--PGKEGDIAIRVKPFRPigiFSGYVDnPKKTEANI------RGDFWL-LGDRGTKDPEGYFHFIGRTDDii 467
Cdd:PRK08279 390 DADGRCIKvkPGEVGLLIGRITDRGP---FDGYTD-PEASEKKIlrdvfkKGDAWFnTGDLMRDDGFGHAQFVDRLGD-- 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 468 nssgTsfcrYR-----IGPSEVENALMEHPAVAETVV--ISSPDpTRGEVVKAFVVLA--PEFlshDPDQLTKLLQQHVK 538
Cdd:PRK08279 464 ----T----FRwkgenVATTEVENALSGFPGVEEAVVygVEVPG-TDGRAGMAAIVLAdgAEF---DLAALAAHLYERLP 531
|
570 580
....*....|....*....|....*....
gi 2025697431 539 SVTAP--------------YKYpRKVEFV 553
Cdd:PRK08279 532 AYAVPlfvrlvpelettgtFKY-RKVDLR 559
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
53-569 |
8.72e-19 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 91.17 E-value: 8.72e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 53 HWANMEKAGKRPPRPALWWmngSGEELkwNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLV 132
Cdd:PRK12316 2006 HQRIAEQAARAPEAIAVVF---GDQHL--SYAELDSRANRLAHRLRA-RGVGPEVRVAIAAERSFELVVALLAVLKAGGA 2079
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 133 FMPGTIQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVApdcsflkiKLLVSDNRREGWLnfktllKDVSNTHHCVETGS 212
Cdd:PRK12316 2080 YVPLDPNYPAERLAYMLEDSGAALLLTQRHLLERLPLPA--------GVARLPLDRDAEW------ADYPDTAPAVQLAG 2145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVW---TISDTGWIVNILTsflePWTLGACVFVYLL 289
Cdd:PRK12316 2146 ENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERY-ELSPADCELqfmSFSFDGAHEQWFH----PLLNGARVLIRDD 2220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKT-GLYIREFYGQTETG 368
Cdd:PRK12316 2221 ELWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAERDGRPPAVRVYCFGGEAVPAASLRLAWEALrPVYLFNGYGPTEAV 2300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 369 LTCRISRTMTVKPGS-----LGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTE-------- 435
Cdd:PRK12316 2301 VTPLLWKCRPQDPCGaayvpIGRALGNRRAYILDADLNLLAPGMAGELYLGGE-----GLARGYLNRPGLTAerfvpdpf 2375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 436 ANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTrGEVVKAFV 515
Cdd:PRK12316 2376 SASGERLYRTGDLARYRADGVVEYLGRIDHQVKIRG-----FRIELGEIEARLQAHPAVREAVVVAQDGAS-GKQLVAYV 2449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 516 VlaPEFLSHDpdqLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK12316 2450 V--PDDAAED---LLAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRKAL 2498
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
58-573 |
9.51e-19 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 91.17 E-value: 9.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWmngsGEElKWNFRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:PRK12316 519 EQVERTPEAPALAF----GEE-TLDYAELNRRANRLAHALI-ERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLD 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVApdcsflKIKLLVSDnRREGWLNFKTllKDVSNTHHCVEtgshEPAA 217
Cdd:PRK12316 593 PEYPAERLAYMLEDSGVQLLLSQSHLGRKLPLAA------GVQVLDLD-RPAAWLEGYS--EENPGTELNPE----NLAY 659
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 218 IYFTSGTSGLPKMAEHSHSSLG--LKAKMDAdswTGLNVSDTVWTISDTGWIVNILTSFlepWTLGACVFVYLLPK---F 292
Cdd:PRK12316 660 VIYTSGSTGKPKGAGNRHRALSnrLCWMQQA---YGLGVGDTVLQKTPFSFDVSVWEFF---WPLMSGARLVVAAPgdhR 733
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 293 DPQTVLKVLSSYPINSLVGAPLIYRMLLQqdlsrykFPHLHSCYT------GGESL---LPETLENWKAKTGLYirEFYG 363
Cdd:PRK12316 734 DPAKLVELINREGVDTLHFVPSMLQAFLQ-------DEDVASCTSlrrivcSGEALpadAQEQVFAKLPQAGLY--NLYG 804
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 364 QTET--GLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTE----AN 437
Cdd:PRK12316 805 PTEAaiDVTHWTCVEEGGDSVPIGRPIANLACYILDANLEPVPVGVLGELYLAGR-----GLARGYHGRPGLTAerfvPS 879
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGD---FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISspdpTRGEVVKAF 514
Cdd:PRK12316 880 PFVAgerMYRTGDLARYRADGVIEYAGRIDHQVKLRG-----LRIELGEIEARLLEHPWVREAAVLA----VDGKQLVGY 950
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 2025697431 515 VVLAPEFLShdpdqLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK12316 951 VVLESEGGD-----WREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDRKALPAPE 1004
|
|
| PRK07445 |
PRK07445 |
O-succinylbenzoic acid--CoA ligase; Reviewed |
362-570 |
1.29e-18 |
|
O-succinylbenzoic acid--CoA ligase; Reviewed
Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 88.51 E-value: 1.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 362 YGQTETGltcriSRTMTVKPG-------SLGTAVPHYDVQvideqgnvLPPGKEGDIAIRVKpfrpiGIFSGYVdnPKKT 434
Cdd:PRK07445 261 YGMTETA-----SQIATLKPDdflagnnSSGQVLPHAQIT--------IPANQTGNITIQAQ-----SLALGYY--PQIL 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 EANIrgdFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAF 514
Cdd:PRK07445 321 DSQG---IFETDDLGYLDAQGYLHILGRNSQKIITGGE-----NVYPAEVEAAILATGLVQDVCVLGLPDPHWGEVVTAI 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 515 VVLAPEflshDPDQLTklLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK07445 393 YVPKDP----SISLEE--LKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQLQ 442
|
|
| A_NRPS_ACVS-like |
cd17648 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ... |
83-569 |
2.78e-18 |
|
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.
Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 87.84 E-value: 2.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRGDRVAVVLSQvPEWWLVT-LGCIRTGLVFMPgtiqmkstdilyrlqsskaraivagd 161
Cdd:cd17648 15 YRELNERANRLAHYLLSVAEIRPDDLVGLVLDK-SELMIIAiLAVWKAGAAYVP-------------------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 162 evaqeVDAVAPDcsfLKIKLLVSDNRREGwlnfktllkdvsnthhcVETGSHEPAAIYFTSGTSGLPK--MAEHsHSSLG 239
Cdd:cd17648 68 -----IDPSYPD---ERIQFILEDTGARV-----------------VITNSTDLAYAIYTSGTTGKPKgvLVEH-GSVVN 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 240 LKAKMDADSWTGLNVSDTVWTISDTgwivnILTSFLEPWT---LGACVFVYLLP--KFDPQTVLKVLSSYPINSLVGAPl 314
Cdd:cd17648 122 LRTSLSERYFGRDNGDEAVLFFSNY-----VFDFFVEQMTlalLNGQKLVVPPDemRFDPDRFYAYINREKVTYLSGTP- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 315 iyrMLLQQ-DLSRykFPHLHSCYTGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTVKP--GSLGTAVPHY 391
Cdd:cd17648 196 ---SVLQQyDLAR--LPHLKRVDAAGEEFTAPVFEKLRSRFAGLIINAYGPTETTVTNHKRFFPGDQRfdKSLGRPVRNT 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 392 DVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGY-----------VDNPKKTEANI-RGDFWLL---GDRGTKDPEGY 456
Cdd:cd17648 271 KCYVLNDAMKRVPVGAVGELYLG-----GDGVARGYlnrpeltaerfLPNPFQTEQERaRGRNARLyktGDLVRWLPSGE 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 457 FHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGE--VVKAFV---VLAPEFLShDPDqltk 531
Cdd:cd17648 346 LEYLGRNDFQVKIRG-----QRIEPGEVEAALASYPGVRECAVVAKEDASQAQsrIQKYLVgyyLPEPGHVP-ESD---- 415
|
490 500 510
....*....|....*....|....*....|....*...
gi 2025697431 532 lLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17648 416 -LLSFLRAKLPRYMVPARLVRLEGIPVTINGKLDVRAL 452
|
|
| FATP_chFAT1_like |
cd05937 |
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ... |
77-574 |
1.87e-17 |
|
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.
Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 85.18 E-value: 1.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 77 EELKWNFRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVfmPGTIQ--MKSTDILYRLQSSKA 154
Cdd:cd05937 2 EGKTWTYSETYDLVLRYAHWLHDDLGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAA--PAFINynLSGDPLIHCLKLSGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 155 RAIVAGDEVaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshePAAIYFTSGTSGLPKMAEHS 234
Cdd:cd05937 80 RFVIVDPDD---------------------------------------------------PAILIYTSGTTGLPKAAAIS 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 235 HSSLGLKAKMDAdSWTGLNVSDTVWT----ISDTGWIVNILTSFLEPWTLGacvfvyLLPKFDPQTVLK--VLSSYPINS 308
Cdd:cd05937 109 WRRTLVTSNLLS-HDLNLKNGDRTYTcmplYHGTAAFLGACNCLMSGGTLA------LSRKFSASQFWKdvRDSGATIIQ 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 309 LVGAPLiyRMLLQQDLSRYKFPHLHSCYTGgESLLPETLENWKAKTGL-YIREFYGQTETgltcrISRTMTVKPGSLGT- 386
Cdd:cd05937 182 YVGELC--RYLLSTPPSPYDRDHKVRVAWG-NGLRPDIWERFRERFNVpEIGEFYAATEG-----VFALTNHNVGDFGAg 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 387 AVPHYD-------------VQVIDEQGNVL-----------PPGKEGDIAIRVkPFRPIGIFSGYVDNPKKTEANI---- 438
Cdd:cd05937 254 AIGHHGlirrwkfenqvvlVKMDPETDDPIrdpktgfcvraPVGEPGEMLGRV-PFKNREAFQGYLHNEDATESKLvrdv 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 439 --RGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPTR-GEVVKAF 514
Cdd:cd05937 333 frKGDIYFrTGDLLRQDADGRWYFLDRLGDTFRWKSEN-----VSTTEVADVLGAHPDIAEANVYGVKVPGHdGRAGCAA 407
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 515 VVLAPEflSHDPDQLTK-LLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEW 574
Cdd:cd05937 408 ITLEES--SAVPTEFTKsLLASLARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLRDEGV 466
|
|
| hsFATP2a_ACSVL_like |
cd05938 |
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ... |
83-548 |
2.15e-17 |
|
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 85.42 E-value: 2.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLV--FMPGTIQMKStdILYRLQSSKARAIVAG 160
Cdd:cd05938 8 YRDVDRRSNQAARALLAHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPvaFLNTNIRSKS--LLHCFRCCGAKVLVVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEVAQEVDAVAPDCSFLKIKLLV--SDNRREGWLNFKTLLKDVSNT-----HHCVETGShEPAAIYFTSGTSGLPKMAEH 233
Cdd:cd05938 86 PELQEAVEEVLPALRADGVSVWYlsHTSNTEGVISLLDKVDAASDEpvpasLRAHVTIK-SPALYIYTSGTTGLPKAARI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 234 SHSSLGLKAKMdaDSWTGLNVSDTVWTI----SDTGWIVNILTSFlepwTLGA-CVfvyLLPKF-------DPQ----TV 297
Cdd:cd05938 165 SHLRVLQCSGF--LSLCGVTADDVIYITlplyHSSGFLLGIGGCI----ELGAtCV---LKPKFsasqfwdDCRkhnvTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 298 LKV---LSSYpinsLVGAPliyrmllQQDLSRYKFPHLhscyTGGESLLPETLENWKAKTG-LYIREFYGQTETGLTcri 373
Cdd:cd05938 236 IQYigeLLRY----LCNQP-------QSPNDRDHKVRL----AIGNGLRADVWREFLRRFGpIRIREFYGSTEGNIG--- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 374 srTM--TVKPGSLGTA-------VPH----YDVQ----VIDEQGNVLP--PGKEGDIAIRVKPFRPigiFSGYVDNPKKT 434
Cdd:cd05938 298 --FFnyTGKIGAVGRVsylykllFPFelikFDVEkeepVRDAQGFCIPvaKGEPGLLVAKITQQSP---FLGYAGDKEQT 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 435 EANI------RGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDPT- 506
Cdd:cd05938 373 EKKLlrdvfkKGDVYFnTGDLLVQDQQNFLYFHDRVGDTFRWKGEN-----VATTEVADVLGLLDFLQEVNVYGVTVPGh 447
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2025697431 507 RGEVVKAFVVLAPEflsHDPDQltKLLQQHVKSVTAPYKYPR 548
Cdd:cd05938 448 EGRIGMAAVKLKPG---HEFDG--KKLYQHVREYLPAYARPR 484
|
|
| hsFATP4_like |
cd05939 |
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ... |
80-570 |
3.13e-17 |
|
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 84.40 E-value: 3.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVa 159
Cdd:cd05939 3 HWTFRELNEYSNKVANFFQAQ-GYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKALI- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 160 gdevaqeVDAVAPDCSFLKIKLLVSDNRregwlNFKTLLkdvsnthhcvetgshepAAIYfTSGTSGLPKMAEHSHSSLg 239
Cdd:cd05939 81 -------FNLLDPLLTQSSTEPPSQDDV-----NFRDKL-----------------FYIY-TSGTTGLPKAAVIVHSRY- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 240 LKAKMDADSWTGLNVSDTVWT----ISDTGWIVNILTSFLEPWTlgacvfVYLLPKFDPQTVLKVLSSY--PINSLVGAp 313
Cdd:cd05939 130 YRIAAGAYYAFGMRPEDVVYDclplYHSAGGIMGVGQALLHGST------VVIRKKFSASNFWDDCVKYncTIVQYIGE- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 314 lIYRMLLQQDLSRYKFPH-LHSCYtgGESLLPETLENWKAKTGL-YIREFYGQTETglTCRISrTMTVKPGSLG--TAVP 389
Cdd:cd05939 203 -ICRYLLAQPPSEEEQKHnVRLAV--GNGLRPQIWEQFVRRFGIpQIGEFYGATEG--NSSLV-NIDNHVGACGfnSRIL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 390 H--YDVQVI-----------DEQGNVLP--PGKEGDIAIRVKPFRPIGIFSGYVD---NPKKTEANI--RGD-FWLLGDR 448
Cdd:cd05939 277 PsvYPIRLIkvdedtgelirDSDGLCIPcqPGEPGLLVGKIIQNDPLRRFDGYVNegaTNKKIARDVfkKGDsAFLSGDV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 449 GTKDPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDP-TRGEVVKAFVVlapeflshDPD 527
Cdd:cd05939 357 LVMDELGYLYFKDRTGDTFRWKGEN-----VSTTEVEGILSNVLGLEDVVVYGVEVPgVEGRAGMAAIV--------DPE 423
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 2025697431 528 QLTKL--LQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05939 424 RKVDLdrFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQ 468
|
|
| FAAL |
cd05931 |
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ... |
60-571 |
4.69e-17 |
|
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.
Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 84.21 E-value: 4.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPAL-WWMNGSGEELKWNFRELSEISQRAANVLSGpcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGL--VFMPG 136
Cdd:cd05931 3 AAARPDRPAYtFLDDEGGREETLTYAELDRRARAIAARLQA--VGKPGDRVLLLAPPGLDFVAAFLGCLYAGAiaVPLPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 137 TIQMKSTD-ILYRLQSSKARAIVAGDEVAQEVDA-VAPDCSFLKIKLLVSDnrregwlnfkTLLKDVSNTHHCVETGSHE 214
Cdd:cd05931 81 PTPGRHAErLAAILADAGPRVVLTTAAALAAVRAfAASRPAAGTPRLLVVD----------LLPDTSAADWPPPSPDPDD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHSSL------GLKAKMDADSWTGlnVSdtvW--TISDTGWIVNILTsflePWTLGACVfv 286
Cdd:cd05931 151 IAYLQYTSGSTGTPKGVVVTHRNLlanvrqIRRAYGLDPGDVV--VS---WlpLYHDMGLIGGLLT----PLYSGGPS-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 287 YLLPKFD----PQTVLKVLSSYPInSLVGAP-----LIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLY 357
Cdd:cd05931 220 VLMSPAAflrrPLRWLRLISRYRA-TISAAPnfaydLCVRRVRDEDLEGLDLSSWRVALNGAEPVRPATLRRFAEAFAPF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 358 ------IREFYGQTETGL--------TCRISRTMT----------VKPG--------SLGTAVPHYDVQVIDEQGN-VLP 404
Cdd:cd05931 299 gfrpeaFRPSYGLAEATLfvsggppgTGPVVLRVDrdalagravaVAADdpaarelvSCGRPLPDQEVRIVDPETGrELP 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 405 PGKEGDIAIRvkpfrpiG--IFSGYVDNPKKTE------ANIRGDFWL-LGDRGTKDpEGYFHFIGRTDDIINSSGtsfc 475
Cdd:cd05931 379 DGEVGEIWVR-------GpsVASGYWGRPEATAetfgalAATDEGGWLrTGDLGFLH-DGELYITGRLKDLIIVRG---- 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 476 RyRIGPSEVENALME-HPAVAET--VVISSPDPTRGEVVkafvVLAPEFLSHDPDQLTKLLQQHVKSVTAPYKY-PRKVE 551
Cdd:cd05931 447 R-NHYPQDIEATAEEaHPALRPGcvAAFSVPDDGEERLV----VVAEVERGADPADLAAIAAAIRAAVAREHGVaPADVV 521
|
570 580
....*....|....*....|..
gi 2025697431 552 FVL--DLPKTITGKIERAKLRA 571
Cdd:cd05931 522 LVRpgSIPRTSSGKIQRRACRA 543
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
216-578 |
5.05e-17 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 85.60 E-value: 5.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVWTISDTGWIVNILTSFlepWTL--GACVFVYLLPKFD 293
Cdd:PRK12467 3240 AYVIYTSGSTGKPKGVGVRHGALANHLCWIAEAY-ELDANDRVLLFMSFSFDGAQERFL---WTLicGGCLVVRDNDLWD 3315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 294 PQTVLKVLSSYPINSLVGAPlIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKTG-LYIREFYGQTETGLT-- 370
Cdd:PRK12467 3316 PEELWQAIHAHRISIACFPP-AYLQQFAEDAGGADCASLDIYVFGGEAVPPAAFEQVKRKLKpRGLTNGYGPTEAVVTvt 3394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 371 ---CRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKT-EANIRGDFWLLG 446
Cdd:PRK12467 3395 lwkCGGDAVCEAPYAPIGRPVAGRSIYVLDGQLNPVPVGVAGELYIGGV-----GLARGYHQRPSLTaERFVADPFSGSG 3469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DR--GTKD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSpDPTRGEVVKAFVVLap 519
Cdd:PRK12467 3470 GRlyRTGDlaryrADGVIEYLGRIDHQVKIRG-----FRIELGEIEARLLQHPSVREAVVLAR-DGAGGKQLVAYVVP-- 3541
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 520 eflsHDPDQ-LTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG 578
Cdd:PRK12467 3542 ----ADPQGdWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKALPDPDAKGSR 3597
|
|
| FATP_FACS |
cd05940 |
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ... |
80-570 |
1.62e-16 |
|
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 82.02 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVfmPGTI--QMKSTDILYRLQSSKARAI 157
Cdd:cd05940 3 ALTYAELDAMANRYARWLKS-LGLKPGDVVALFMENRPEYVLLWLGLVKIGAV--AALInyNLRGESLAHCLNVSSAKHL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 158 VAgdevaqevdavapdcsflkikllvsdnrregwlnfktllkdvsnthhcvetgshEPAAIYFTSGTSGLPKMAEHSHSS 237
Cdd:cd05940 80 VV------------------------------------------------------DAALYIYTSGTTGLPKAAIISHRR 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 238 LgLKAKMDADSWTGLNVSDTVWTI----SDTGWIVNILTSFLEpwtlGACVFvyLLPKFDPQTVLKVLSSYPINSLVGAP 313
Cdd:cd05940 106 A-WRGGAFFAGSGGALPSDVLYTClplyHSTALIVGWSACLAS----GATLV--IRKKFSASNFWDDIRKYQATIFQYIG 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 314 LIYRMLLQQDLSRYKFPHLHSCYTGgESLLPETLENWKAKTGL-YIREFYGQTE--TGLTCRISRTMTV------KPGSL 384
Cdd:cd05940 179 ELCRYLLNQPPKPTERKHKVRMIFG-NGLRPDIWEEFKERFGVpRIAEFYAATEgnSGFINFFGKPGAIgrnpslLRKVA 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 385 GTAVPHYDVQ----VIDEQGNV--LPPGKEGDIAIRVKPFRPigiFSGYVDnPKKTEANI------RGDFWLL-GDRGTK 451
Cdd:cd05940 258 PLALVKYDLEsgepIRDAEGRCikVPRGEPGLLISRINPLEP---FDGYTD-PAATEKKIlrdvfkKGDAWFNtGDLMRL 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 452 DPEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAVAETVVISSPDP-TRGEVVKAFVVLAPEflshDPDQLT 530
Cdd:cd05940 334 DGEGFWYFVDRLGDTFRWKGEN-----VSTTEVAAVLGAFPGVEEANVYGVQVPgTDGRAGMAAIVLQPN----EEFDLS 404
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 2025697431 531 KlLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:cd05940 405 A-LAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLR 443
|
|
| A_NRPS_PpsD_like |
cd17650 |
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ... |
82-569 |
4.44e-16 |
|
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 80.97 E-value: 4.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 82 NFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKAraivagd 161
Cdd:cd17650 14 TYRELNERANQLARTLRGL-GVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYMLEDSGA------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 162 evaqevdavapdcsflkiKLLVSDnrregwlnfktllkdvsnthhcvetgSHEPAAIYFTSGTSGLPK--MAEH---SHS 236
Cdd:cd17650 86 ------------------KLLLTQ--------------------------PEDLAYVIYTSGTTGKPKgvMVEHrnvAHA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 237 SLGLKAKMDADSWT--GLNVSDTVWTISDTGWIVNILTSflepwtlGACVFVYLLPKFDPQTVLKVLSSYPINSLVGAPL 314
Cdd:cd17650 122 AHAWRREYELDSFPvrLLQMASFSFDVFAGDFARSLLNG-------GTLVICPDEVKLDPAALYDLILKSRITLMESTPA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 315 IYRMLLQQ-DLSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYIR--EFYGQTETGL-TCRISRTMTVKPGS----LGT 386
Cdd:cd17650 195 LIRPVMAYvYRNGLDLSAMRLLIVGSDGCKAQDFKTLAARFGQGMRiiNSYGVTEATIdSTYYEEGRDPLGDSanvpIGR 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 387 AVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGD-------FWLLGDRGTKDPEGYFHF 459
Cdd:cd17650 275 PLPNTAMYVLDERLQPQPVGVAGELYIGGA-----GVARGYLNRPELTAERFVENpfapgerMYRTGDLARWRADGNVEL 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 460 IGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDpTRGEVVKAFVVLAPEFLshDPDQLTKLLQQHVKS 539
Cdd:cd17650 350 LGRVDHQVKIRG-----FRIELGEIESQLARHPAIDEAVVAVRED-KGGEARLCAYVVAAATL--NTAELRAFLAKELPS 421
|
490 500 510
....*....|....*....|....*....|.
gi 2025697431 540 VTAPYKYprkveFVLD-LPKTITGKIERAKL 569
Cdd:cd17650 422 YMIPSYY-----VQLDaLPLTPNGKVDRRAL 447
|
|
| ACSBG_like |
cd05933 |
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ... |
80-500 |
1.03e-15 |
|
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341256 [Multi-domain] Cd Length: 596 Bit Score: 80.09 E-value: 1.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 80 KWNFRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGlVFMPGTIQMKSTD-ILYRLQSSKARAIV 158
Cdd:cd05933 8 TLTYKEYYEACRQAAKAFL-KLGLERFHGVGILGFNSPEWFIAAVGAIFAG-GIAVGIYTTNSPEaCQYVAETSEANILV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 159 AGDEV-AQEVDAVAPDCSFLKIKLLVSDNRRE------GWLNFKTLLKDVSNT--HHCVETGS-HEPAAIYFTSGTSGLP 228
Cdd:cd05933 86 VENQKqLQKILQIQDKLPHLKAIIQYKEPLKEkepnlySWDEFMELGRSIPDEqlDAIISSQKpNQCCTLIYTSGTTGMP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 229 KMAEHSHSSLGLKAK-----MD------------------------ADSWTGLNVSDTVWTIS-DT--GWIVNIL----- 271
Cdd:cd05933 166 KGVMLSHDNITWTAKaasqhMDlrpatvgqesvvsylplshiaaqiLDIWLPIKVGGQVYFAQpDAlkGTLVKTLrevrp 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 272 TSFLE-PWtlgacvfVYllPKFDPQTVLKVLSSYPINSLV--------------------GAPLIYRMLLQQDLSRYK-- 328
Cdd:cd05933 246 TAFMGvPR-------VW--EKIQEKMKAVGAKSGTLKRKIaswakgvgletnlklmggesPSPLFYRLAKKLVFKKVRka 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 329 --FPHLHSCYTGGESLLPETLENWkakTGLYIR--EFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNvlp 404
Cdd:cd05933 317 lgLDRCQKFFTGAAPISRETLEFF---LSLNIPimELYGMSETSGPHTISNPQAYRLLSCGKALPGCKTKIHNPDAD--- 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 405 pgKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSfcryRIGPSE 483
Cdd:cd05933 391 --GIGEICFWGR-----HVFMGYLNMEDKTEEAIDEDGWLhSGDLGKLDEDGFLYITGRIKELIITAGGE----NVPPVP 459
|
490
....*....|....*...
gi 2025697431 484 VENAL-MEHPAVAETVVI 500
Cdd:cd05933 460 IEDAVkKELPIISNAMLI 477
|
|
| entF |
PRK10252 |
enterobactin non-ribosomal peptide synthetase EntF; |
58-569 |
1.15e-15 |
|
enterobactin non-ribosomal peptide synthetase EntF;
Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 80.86 E-value: 1.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALwwmngSGEELKWNFRELSEISQRAANVLSGPcGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:PRK10252 466 QQAAKTPDAPAL-----ADARYQFSYREMREQVVALANLLRER-GVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLD 539
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKARAIVAGDEVAQEVDAVaPDCSFLKIK--LLVSDNRREGwlnfktllkdVSNTHHcvetgsheP 215
Cdd:PRK10252 540 TGYPDDRLKMMLEDARPSLLITTADQLPRFADV-PDLTSLCYNapLAPQGAAPLQ----------LSQPHH--------T 600
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPK--MAEH-----------SHSSLGLKAKMDADSWTGLNVSdtVWtisdtgwivniltSFLEPWTLGA 282
Cdd:PRK10252 601 AYIIFTSGSTGRPKgvMVGQtaivnrllwmqNHYPLTADDVVLQKTPCSFDVS--VW-------------EFFWPFIAGA 665
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVfVYLLPKF--DPQTVLKVLSSYPINSLVGAPliyRML------LQQDLSRYKFPHLHSCYTGGESLLPETLENWKAKT 354
Cdd:PRK10252 666 KL-VMAEPEAhrDPLAMQQFFAEYGVTTTHFVP---SMLaafvasLTPEGARQSCASLRQVFCSGEALPADLCREWQQLT 741
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 355 GLYIREFYGQTET----------GLTCRISRTMTVkPgsLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIF 424
Cdd:PRK10252 742 GAPLHNLYGPTEAavdvswypafGEELAAVRGSSV-P--IGYPVWNTGLRILDARMRPVPPGVAGDLYLT-----GIQLA 813
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 425 SGYVDNPKKTEANIRGDFWLLGDR--GTKD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHP----A 493
Cdd:PRK10252 814 QGYLGRPDLTASRFIADPFAPGERmyRTGDvarwlDDGAVEYLGRSDDQLKIRG-----QRIELGEIDRAMQALPdveqA 888
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 494 VAETVVISSPDPTRGEVVK--AFVVlAPEFLSHDPDqltkLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:PRK10252 889 VTHACVINQAAATGGDARQlvGYLV-SQSGLPLDTS----ALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKAL 961
|
|
| AACS |
cd05943 |
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ... |
42-564 |
1.62e-15 |
|
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.
Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 79.62 E-value: 1.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 42 AKFNFANDVVDHwanmekagKRPPRPALWWMNGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWL 121
Cdd:cd05943 68 ARLNYAENLLRH--------ADADDPAAIYAAEDGERTEVTWAELRRRVARLAAALRA-LGVKPGDRVAGYLPNIPEAVV 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 122 VTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGDEVA------------QEVDAVAPDcsfLKIKLLVSDNRRE 189
Cdd:cd05943 139 AMLATASIGAIWSSCSPDFGVPGVLDRFGQIEPKVLFAVDAYTyngkrhdvrekvAELVKGLPS---LLAVVVVPYTVAA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 190 GWLNFK-----TLLKDVSNTHHCVETG------SHePAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTV 258
Cdd:cd05943 216 GQPDLSkiakaLTLEDFLATGAAGELEfeplpfDH-PLYILYSSGTTGLPKCIVHGAGGTLLQHLKEHILHCDLRPGDRL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 259 WTISDTGWIV-NILTSFLepwTLGACVFVY----LLPkfDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLS---RYKFP 330
Cdd:cd05943 295 FYYTTCGWMMwNWLVSGL---AVGATIVLYdgspFYP--DTNALWDLADEEGITVFGTSAKYLDALEKAGLKpaeTHDLS 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 331 HLHSCYTGGESLLPETLE--NWKAKTGLYIREFYGQTE-TGLTCRISRTMTVKPGSLGTAVPHYDVQVIDEQGNVLPpGK 407
Cdd:cd05943 370 SLRTILSTGSPLKPESFDyvYDHIKPDVLLASISGGTDiISCFVGGNPLLPVYRGEIQCRGLGMAVEAFDEEGKPVW-GE 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 408 EGDIAIrVKPF--RPIGiFSGYVDNPKKTEA--NIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSE 483
Cdd:cd05943 449 KGELVC-TKPFpsMPVG-FWNDPDGSRYRAAyfAKYPGVWAHGDWIEITPRGGVVILGRSDGTLNPGGV-----RIGTAE 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 484 VENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEFlshdpdQLTKLLQQHVKSVTA----PYKYPRKVEFVLDLPKT 559
Cdd:cd05943 522 IYRVVEKIPEVEDSLVVGQEWKDGDERVILFVKLREGV------ELDDELRKRIRSTIRsalsPRHVPAKIIAVPDIPRT 595
|
....*
gi 2025697431 560 ITGKI 564
Cdd:cd05943 596 LSGKK 600
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
58-576 |
1.58e-14 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 77.52 E-value: 1.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 58 EKAGKRPPRPALWWMNGSgeelkWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGT 137
Cdd:PRK05691 1139 EQARQTPERIALVWDGGS-----LDYAELHAQANRLAHYLRD-KGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLD 1212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 138 IQMKSTDILYRLQSSKA------RAIVAGDEVAQEVDAVAPDCSFLkikllvsdnrrEGWLNFKTLLkdvsNTHhcvetG 211
Cdd:PRK05691 1213 PDYPAERLAYMLADSGVellltqSHLLERLPQAEGVSAIALDSLHL-----------DSWPSQAPGL----HLH-----G 1272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 212 SHEPAAIYfTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDTVWTISDTGWIVNILTSFlepWTL-GACVFVYLLP 290
Cdd:PRK05691 1273 DNLAYVIY-TSGSTGQPKGVGNTHAALAERLQWMQATY-ALDDSDVLMQKAPISFDVSVWECF---WPLiTGCRLVLAGP 1347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 --KFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRyKFPHLHSCYTGGESLLPE----TLENWKAKTgLYIRefYGQ 364
Cdd:PRK05691 1348 geHRDPQRIAELVQQYGVTTLHFVPPLLQLFIDEPLAA-ACTSLRRLFSGGEALPAElrnrVLQRLPQVQ-LHNR--YGP 1423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 365 TETGLT-----CRISRTMTVKPGS-LGTAVphydVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKTEANI 438
Cdd:PRK05691 1424 TETAINvthwqCQAEDGERSPIGRpLGNVL----CRVLDAELNLLPPGVAGELCIG-----GAGLARGYLGRPALTAERF 1494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 439 RGD--------FWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEV 510
Cdd:PRK05691 1495 VPDplgedgarLYRTGDRARWNADGALEYLGRLDQQVKLRG-----FRVEPEEIQARLLAQPGVAQAAVLVREGAAGAQL 1569
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025697431 511 VKAFVVLApeflshDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKT 576
Cdd:PRK05691 1570 VGYYTGEA------GQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALPEPVWQQ 1629
|
|
| PRK03584 |
PRK03584 |
acetoacetate--CoA ligase; |
42-564 |
2.07e-14 |
|
acetoacetate--CoA ligase;
Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 76.37 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 42 AKFNFANDVVDHwanmekagKRPPRPALWWMNGSGEELKWNFRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWL 121
Cdd:PRK03584 84 ARLNYAENLLRH--------RRDDRPAIIFRGEDGPRRELSWAELRRQVAALAAALRA-LGVGPGDRVAAYLPNIPETVV 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 122 VTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAGD---------EVAQEVDAVAPDCSFLKiKLLVSDNrregwL 192
Cdd:PRK03584 155 AMLATASLGAIWSSCSPDFGVQGVLDRFGQIEPKVLIAVDgyryggkafDRRAKVAELRAALPSLE-HVVVVPY-----L 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 193 NFKTLLKDVSNTHHCVE-TGSHEPAAIYFT-------------SGTSGLPKMAEHSH--------SSLGLKAKMDADswt 250
Cdd:PRK03584 229 GPAAAAAALPGALLWEDfLAPAEAAELEFEpvpfdhplwilysSGTTGLPKCIVHGHggillehlKELGLHCDLGPG--- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 251 glnvsDTVWTISDTGWIV-NILTSFLepwTLGACVFVY----LLPkfDPQTVLKVLSSYPINSL-VGAPLIyRMLLQQDL 324
Cdd:PRK03584 306 -----DRFFWYTTCGWMMwNWLVSGL---LVGATLVLYdgspFYP--DPNVLWDLAAEEGVTVFgTSAKYL-DACEKAGL 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 325 S---RYKFPHLHSCYTGGESLLPETL----ENWKAktGLYIREFYGQTETgLTCRI--SRTMTVKPG-----SLGTAVph 390
Cdd:PRK03584 375 VpgeTHDLSALRTIGSTGSPLPPEGFdwvyEHVKA--DVWLASISGGTDI-CSCFVggNPLLPVYRGeiqcrGLGMAV-- 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 391 ydvQVIDEQGN-VLppGKEGDIAIRvKPF--RPIGiFSGYVDNPKKTEA------NIrgdfWLLGDRGTKDPEGYFHFIG 461
Cdd:PRK03584 450 ---EAWDEDGRpVV--GEVGELVCT-KPFpsMPLG-FWNDPDGSRYRDAyfdtfpGV----WRHGDWIEITEHGGVVIYG 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 462 RTDDIINSSGTsfcryRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEF-LShdpDQLTKLLQQHVKSV 540
Cdd:PRK03584 519 RSDATLNRGGV-----RIGTAEIYRQVEALPEVLDSLVIGQEWPDGDVRMPLFVVLAEGVtLD---DALRARIRTTIRTN 590
|
570 580
....*....|....*....|....
gi 2025697431 541 TAPYKYPRKVEFVLDLPKTITGKI 564
Cdd:PRK03584 591 LSPRHVPDKIIAVPDIPRTLSGKK 614
|
|
| PLN03052 |
PLN03052 |
acetate--CoA ligase; Provisional |
57-572 |
4.67e-14 |
|
acetate--CoA ligase; Provisional
Pssm-ID: 215553 [Multi-domain] Cd Length: 728 Bit Score: 75.12 E-value: 4.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 57 MEKAGKRPPRPALWWMNGSGEELKWNFRELSEI---SQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVF 133
Cdd:PLN03052 182 TPKPSKTDDSIAIIWRDEGSDDLPVNRMTLSELrsqVSRVANALDA-LGFEKGDAIAIDMPMNVHAVIIYLAIILAGCVV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 134 MPGTIQMKSTDILYRLQSSKARAIVAGDEV----------AQEVDAVAP-------DCSFLKIKLlvsdnrREG---WLN 193
Cdd:PLN03052 261 VSIADSFAPSEIATRLKISKAKAIFTQDVIvrggksiplySRVVEAKAPkaivlpaDGKSVRVKL------REGdmsWDD 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 194 FKTLLKDVS--NTHHCVETGSHEPAAIYFTSGTSGLPKMAEHSHSSlGLKAKmdADSWTGLNV--SDTVWTISDTGWIVN 269
Cdd:PLN03052 335 FLARANGLRrpDEYKAVEQPVEAFTNILFSSGTTGEPKAIPWTQLT-PLRAA--ADAWAHLDIrkGDIVCWPTNLGWMMG 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 270 ---ILTSFLEpwtlGACVFVY-------LLPKFDPQTVLKVLSSYPinSLVGAPLIYRMLLQQDLSRYKFphlhSCYTGG 339
Cdd:PLN03052 412 pwlVYASLLN----GATLALYngsplgrGFAKFVQDAKVTMLGTVP--SIVKTWKNTNCMAGLDWSSIRC----FGSTGE 481
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 340 ESLLPETLenWKAKTGLY--IREFYGQTETGlTCRISRTMtVKPGSLG---TAVPHYDVQVIDEQGNVLP---PGKeGDI 411
Cdd:PLN03052 482 ASSVDDYL--WLMSRAGYkpIIEYCGGTELG-GGFVTGSL-LQPQAFAafsTPAMGCKLFILDDSGNPYPddaPCT-GEL 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 412 AIRVKPFRPIGI----------FSGYvdnPKKTEANIRGDfwllGDRGTKDPEGYFHFIGRTDDIINSSGtsfcryrIGP 481
Cdd:PLN03052 557 ALFPLMFGASSTllnadhykvyFKGM---PVFNGKILRRH----GDIFERTSGGYYRAHGRADDTMNLGG-------IKV 622
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 482 SEVE-----NALmeHPAVAETVVISSPDPTRG--EVVKAFVVLAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVL 554
Cdd:PLN03052 623 SSVEiervcNAA--DESVLETAAIGVPPPGGGpeQLVIAAVLKDPPGSNPDLNELKKIFNSAIQKKLNPLFKVSAVVIVP 700
|
570
....*....|....*...
gi 2025697431 555 DLPKTITGKIERAKLRAK 572
Cdd:PLN03052 701 SFPRTASNKVMRRVLRQQ 718
|
|
| PRK07768 |
PRK07768 |
long-chain-fatty-acid--CoA ligase; Validated |
208-571 |
4.86e-14 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 75.03 E-value: 4.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 208 VETGSHEPAAIYFTSGTSGLPKMAEHSHSSL-----GLKAKMDADSWTGLNVSdtvW--TISDTGwIVNILTSflePWTL 280
Cdd:PRK07768 147 VETGEDDLALMQLTSGSTGSPKAVQITHGNLyanaeAMFVAAEFDVETDVMVS---WlpLFHDMG-MVGFLTV---PMYF 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 281 GACVfVYLLP-KF--DPQTVLKVLSSYPiNSLVGAP-----LIYRMLLQQ------DLSRYKFphlhsCYTGGESLLPET 346
Cdd:PRK07768 220 GAEL-VKVTPmDFlrDPLLWAELISKYR-GTMTAAPnfayaLLARRLRRQakpgafDLSSLRF-----ALNGAEPIDPAD 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 347 LENW---KAKTGLY---IREFYGQTETGLTCRISRT---MTV------------------KPG-----SLGTAVPHYDVQ 394
Cdd:PRK07768 293 VEDLldaGARFGLRpeaILPAYGMAEATLAVSFSPCgagLVVdevdadllaalrravpatKGNtrrlaTLGPPLPGLEVR 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 395 VIDEQGNVLPPGKEGDIAIRVKPFRPigifsGY--VDNPKKTEANirgDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSG 471
Cdd:PRK07768 373 VVDEDGQVLPPRGVGVIELRGESVTP-----GYltMDGFIPAQDA---DGWLdTGDLGYLTEEGEVVVCGRVKDVIIMAG 444
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 472 TSfcryrIGPSEVENALMEHPAV--AETVVISSPDPTRGEvvkAFVVLAPEFLSHDPDQLTKLLQQHVKSVTAPYKY-PR 548
Cdd:PRK07768 445 RN-----IYPTDIERAAARVEGVrpGNAVAVRLDAGHSRE---GFAVAVESNAFEDPAEVRRIRHQVAHEVVAEVGVrPR 516
|
410 420
....*....|....*....|....*.
gi 2025697431 549 KVeFVL---DLPKTITGKIERAKLRA 571
Cdd:PRK07768 517 NV-VVLgpgSIPKTPSGKLRRANAAE 541
|
|
| PRK09192 |
PRK09192 |
fatty acyl-AMP ligase; |
83-571 |
1.71e-13 |
|
fatty acyl-AMP ligase;
Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 73.12 E-value: 1.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFMPGTIQMK-------STDILYRLQSSKAR 155
Cdd:PRK09192 52 YQTLRARAEAGARRLLA-LGLKPGDRVALIAETDGDFVEAFFACQYAGLVPVPLPLPMGfggresyIAQLRGMLASAQPA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 156 AIVAGDEVAQEVDAVApdcsflkikllvsDNRREGWLNFKTLLKDVSNTHHCVETGS-HEPAAIYFTSGTSGLPKMAEHS 234
Cdd:PRK09192 131 AIITPDELLPWVNEAT-------------HGNPLLHVLSHAWFKALPEADVALPRPTpDDIAYLQYSSGSTRFPRGVIIT 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 235 HSSLglKAKMDADSWTGLNVSDTVWTIS------DTGWIvnilTSFLEPwtLGACVFVYLLPKFD----PQTVLKVLS-- 302
Cdd:PRK09192 198 HRAL--MANLRAISHDGLKVRPGDRCVSwlpfyhDMGLV----GFLLTP--VATQLSVDYLPTRDfarrPLQWLDLISrn 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 303 ----SYpiNSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAK---TGLYIREF---YGQTETGLTCR 372
Cdd:PRK09192 270 rgtiSY--SPPFGYELCARRVNSKDLAELDLSCWRVAGIGADMIRPDVLHQFAEAfapAGFDDKAFmpsYGLAEATLAVS 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 373 IS------RTMTVKPGSL----------------------GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvKPfrpiGIF 424
Cdd:PRK09192 348 FSplgsgiVVEEVDRDRLeyqgkavapgaetrrvrtfvncGKALPGHEIEIRNEAGMPLPERVVGHICVR-GP----SLM 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 425 SGYVDNPKKTEAnIRGDFWL-LGDRGTKDpEGYFHFIGRTDDIINSSGTSfcryrIGPSEVENALMEHPAV--AETVVIS 501
Cdd:PRK09192 423 SGYFRDEESQDV-LAADGWLdTGDLGYLL-DGYLYITGRAKDLIIINGRN-----IWPQDIEWIAEQEPELrsGDAAAFS 495
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2025697431 502 SPDPTRGEVVkafvVLAPEFLShDPDQLTKLLQQHVKSVTAPYKYPRKVEFV--LDLPKTITGKIERAKLRA 571
Cdd:PRK09192 496 IAQENGEKIV----LLVQCRIS-DEERRGQLIHALAALVRSEFGVEAAVELVppHSLPRTSSGKLSRAKAKK 562
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
214-573 |
3.32e-12 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 69.57 E-value: 3.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSwtgLNVSDtvwtiSDTgwIVNIL----------TSFLePWTLG-A 282
Cdd:PRK08633 783 DTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDV---FNLRN-----DDV--ILSSLpffhsfgltvTLWL-PLLEGiK 851
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVFVYllpkfDP---QTVLKVLSSYPINSLVGAPLIYRMLLQQD-LSRYKFPHLHSCYTGGESLLPETLENWKAKTGLYI 358
Cdd:PRK08633 852 VVYHP-----DPtdaLGIAKLVAKHRATILLGTPTFLRLYLRNKkLHPLMFASLRLVVAGAEKLKPEVADAFEEKFGIRI 926
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 359 REFYGQTETG--LTCRISRTMTV--------KPGSLGTAVPHYDVQVID-EQGNVLPPGKEGDIAIrvkpfRPIGIFSGY 427
Cdd:PRK08633 927 LEGYGATETSpvASVNLPDVLAAdfkrqtgsKEGSVGMPLPGVAVRIVDpETFEELPPGEDGLILI-----GGPQVMKGY 1001
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 428 VDNPKKTE---ANIRGDFWLL-GDRGTKDPEGYFHFIGRtddiinssgtsFCRY-RIG----P-SEVENALmeHPAVAET 497
Cdd:PRK08633 1002 LGDPEKTAeviKDIDGIGWYVtGDKGHLDEDGFLTITDR-----------YSRFaKIGgemvPlGAVEEEL--AKALGGE 1068
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 498 ----VVISSPDPTRGEVVkafVVLapefLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIE--RAKLRA 571
Cdd:PRK08633 1069 evvfAVTAVPDEKKGEKL---VVL----HTCGAEDVEELKRAIKESGLPNLWKPSRYFKVEALPLLGSGKLDlkGLKELA 1141
|
..
gi 2025697431 572 KE 573
Cdd:PRK08633 1142 LA 1143
|
|
| PRK09274 |
PRK09274 |
peptide synthase; Provisional |
60-516 |
7.64e-12 |
|
peptide synthase; Provisional
Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 68.00 E-value: 7.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 60 AGKRPPRPALWWMNGSGEELKWNFRELS--EISQRAANVLSG--PCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFM- 134
Cdd:PRK09274 16 AQERPDQLAVAVPGGRGADGKLAYDELSfaELDARSDAIAHGlnAAGIGRGMRAVLMVTPSLEFFALTFALFKAGAVPVl 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 135 --PGtiqMKSTDILYRLQSSKARAIVaGDEVAQEVDAVAPdCSFLKIKLLVSDNRREGWLNF--KTLLKDVSNT-HHCVE 209
Cdd:PRK09274 96 vdPG---MGIKNLKQCLAEAQPDAFI-GIPKAHLARRLFG-WGKPSVRRLVTVGGRLLWGGTtlATLLRDGAAApFPMAD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 210 TGSHEPAAIYFTSGTSGLPKMAEHSHSSLglKAKMDAdswtglnvSDTVWTISDTGwivnI-LTSF----LEPWTLGACV 284
Cdd:PRK09274 171 LAPDDMAAILFTSGSTGTPKGVVYTHGMF--EAQIEA--------LREDYGIEPGE----IdLPTFplfaLFGPALGMTS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 285 fvyLLPKFD--------PQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSR-YKFPHLHSCYTGGESLLPETLENwkaktg 355
Cdd:PRK09274 237 ---VIPDMDptrpatvdPAKLFAAIERYGVTNLFGSPALLERLGRYGEANgIKLPSLRRVISAGAPVPIAVIER------ 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 356 lyIREF----------YGQTETGLTCRIS--------RTMTVKPGS--LGTAVPHYDVQVID---------EQGNVLPPG 406
Cdd:PRK09274 308 --FRAMlppdaeiltpYGATEALPISSIEsreilfatRAATDNGAGicVGRPVDGVEVRIIAisdapipewDDALRLATG 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 407 KEGDIAIRvkpfrpiG--IFSGYVDNPKKTEAN----IRGDFW-LLGDRGTKDPEGYFHFIGR-TDDIINSSGTSFcryr 478
Cdd:PRK09274 386 EIGEIVVA-------GpmVTRSYYNRPEATRLAkipdGQGDVWhRMGDLGYLDAQGRLWFCGRkAHRVETAGGTLY---- 454
|
490 500 510
....*....|....*....|....*....|....*...
gi 2025697431 479 igPSEVENALMEHPAVAETVVISSPDPtrGEVVKAFVV 516
Cdd:PRK09274 455 --TIPCERIFNTHPGVKRSALVGVGVP--GAQRPVLCV 488
|
|
| PRK07824 |
PRK07824 |
o-succinylbenzoate--CoA ligase; |
447-571 |
1.67e-11 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 65.84 E-value: 1.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 447 DRGTKDpEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFVVLAPEflshdP 526
Cdd:PRK07824 240 DLGALD-DGVLTVLGRADDAISTGG-----LTVLPQVVEAALATHPAVADCAVFGLPDDRLGQRVVAAVVGDGG-----P 308
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2025697431 527 DQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK07824 309 APTLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRALVR 353
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
213-573 |
2.89e-11 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 66.73 E-value: 2.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 213 HEPAAIYfTSGTSGLPKMAEHSHSSLGLKAKMDADSWtGLNVSDT---VWTISDTGWIVNILTSFLEpwtlGACVFVYLL 289
Cdd:PRK05691 2334 HQAYLIY-TSGSTGKPKGVVVSHGEIAMHCQAVIERF-GMRADDCelhFYSINFDAASERLLVPLLC----GARVVLRAQ 2407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 290 PKFDPQTVLKVLSSYPINSLVGAPLIYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLENWKAK-TGLYIREFYGQTET- 367
Cdd:PRK05691 2408 GQWGAEEICQLIREQQVSILGFTPSYGSQLAQWLAGQGEQLPVRMCITGGEALTGEHLQRIRQAfAPQLFFNAYGPTETv 2487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 368 --GLTCRISRTMTVKPGSL--GTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTE-------- 435
Cdd:PRK05691 2488 vmPLACLAPEQLEEGAASVpiGRVVGARVAYILDADLALVPQGATGELYVGGA-----GLAQGYHDRPGLTAerfvadpf 2562
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 436 ANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTRGEVVKAFV 515
Cdd:PRK05691 2563 AADGGRLYRTGDLVRLRADGLVEYVGRIDHQVKIRG-----FRIELGEIESRLLEHPAVREAVVLALDTPSGKQLAGYLV 2637
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2025697431 516 VLAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK05691 2638 SAVAGQDDEAQAALREALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRALPAPD 2695
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
215-571 |
3.75e-11 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 66.14 E-value: 3.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHSSLgLKAKMDADSWTGLNVSDTVWtisdtgwivNILTSF----LepwTLGacvfvyllp 290
Cdd:PRK06814 795 PAVILFTSGSEGTPKGVVLSHRNL-LANRAQVAARIDFSPEDKVF---------NALPVFhsfgL---TGG--------- 852
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 291 kfdpqTVLKVLSSYPInSLVGAPLIYR------------MLLQQD--LS-------RYKFPHLHSCYTGGESLLPETLEN 349
Cdd:PRK06814 853 -----LVLPLLSGVKV-FLYPSPLHYRiipeliydtnatILFGTDtfLNgyaryahPYDFRSLRYVFAGAEKVKEETRQT 926
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 350 WKAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVP--HY---DVQVIDEQGNVLPPGKEgdiairvkpfrpigIF 424
Cdd:PRK06814 927 WMEKFGIRILEGYGVTETAPVIALNTPMHNKAGTVGRLLPgiEYrlePVPGIDEGGRLFVRGPN--------------VM 992
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 425 SGYV--DNPKKTEANIRGdfWL-LGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVIS 501
Cdd:PRK06814 993 LGYLraENPGVLEPPADG--WYdTGDIVTIDEEGFITIKGRAKRFAKIAG-----EMISLAAVEELAAELWPDALHAAVS 1065
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025697431 502 SPDPTRGEVvkafVVLapefLSHDPDQLTKLLQQHVKSVTAPYKY-PRKVEFVLDLPKTITGKIERAKLRA 571
Cdd:PRK06814 1066 IPDARKGER----IIL----LTTASDATRAAFLAHAKAAGASELMvPAEIITIDEIPLLGTGKIDYVAVTK 1128
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
214-570 |
1.30e-10 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 64.35 E-value: 1.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 214 EPAAIYFTSGTSGLPKMAEHSHSSLglkakmdadswtgLNVSDTVWTISDT----------------GWIVNILTsfleP 277
Cdd:PRK08043 366 DAALILFTSGSEGHPKGVVHSHKSL-------------LANVEQIKTIADFtpndrfmsalplfhsfGLTVGLFT----P 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 278 WTLGACVFVYLLP---KFDPQTVlkvlssYPINSLVgapLIYRMLLQQDLSR----YKFPHLHSCYTGGESLLPETLENW 350
Cdd:PRK08043 429 LLTGAEVFLYPSPlhyRIVPELV------YDRNCTV---LFGTSTFLGNYARfanpYDFARLRYVVAGAEKLQESTKQLW 499
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 351 KAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVID----EQGNVLppgkegdiairvkPFRPIGIFSG 426
Cdd:PRK08043 500 QDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSvpgiEQGGRL-------------QLKGPNIMNG 566
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 427 Y--VDNPKKTEA----NIRGDF---WL-LGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVEN-ALMEHPAVA 495
Cdd:PRK08043 567 YlrVEKPGVLEVptaeNARGEMergWYdTGDIVRFDEQGFVQIQGRAKRFAKIAGE-----MVSLEMVEQlALGVSPDKQ 641
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2025697431 496 ETVVISSpDPTRGEVVKAFVVLApeflshdpdQLTK-LLQQHVKSVTAP-YKYPRKVEFVLDLPKTITGKIERAKLR 570
Cdd:PRK08043 642 HATAIKS-DASKGEALVLFTTDS---------ELTReKLQQYAREHGVPeLAVPRDIRYLKQLPLLGSGKPDFVTLK 708
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
216-573 |
9.96e-10 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 61.72 E-value: 9.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPK--MAEHSHSslgLKAKMDADSWTGLNVSDTVWTISDTGWIVNILtSFLEPWTLGACVFVylLPK-- 291
Cdd:PRK05691 3872 AYVIYTSGSTGLPKgvMVEQRGM---LNNQLSKVPYLALSEADVIAQTASQSFDISVW-QFLAAPLFGARVEI--VPNai 3945
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 292 -FDPQTVLKVLSSYPINSLVGAP-LIYRMLLQQDLS----RYKFPhlhscytGGESLLPETLENWKAK---TGLYirEFY 362
Cdd:PRK05691 3946 aHDPQGLLAHVQAQGITVLESVPsLIQGMLAEDRQAldglRWMLP-------TGEAMPPELARQWLQRypqIGLV--NAY 4016
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 363 GQTETGLTCRISRT-MTVKPGS---LGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRvkpfrPIGIFSGYVDNPKKT-EAN 437
Cdd:PRK05691 4017 GPAECSDDVAFFRVdLASTRGSylpIGSPTDNNRLYLLDEALELVPLGAVGELCVA-----GTGVGRGYVGDPLRTaLAF 4091
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWLLGDR--GTKD-----PEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDPTrGEV 510
Cdd:PRK05691 4092 VPHPFGAPGERlyRTGDlarrrSDGVLEYVGRIDHQVKIRG-----YRIELGEIEARLHEQAEVREAAVAVQEGVN-GKH 4165
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 511 VKAFVVlaPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKE 573
Cdd:PRK05691 4166 LVGYLV--PHQTVLAQGALLERIKQRLRAELPDYMVPLHWLWLDRLPLNANGKLDRKALPALD 4226
|
|
| PLN03051 |
PLN03051 |
acyl-activating enzyme; Provisional |
215-572 |
3.95e-09 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215552 [Multi-domain] Cd Length: 499 Bit Score: 59.06 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 215 PAAIYFTSGTSGLPKMAEHSHSSlGLKAKMDADSWTGLNVSDTVWTISDTGWIVNiltsflePWTL------GACVFVY- 287
Cdd:PLN03051 121 VTNILFSSGTTGEPKAIPWTHLS-PLRCASDGWAHMDIQPGDVVCWPTNLGWMMG-------PWLLysaflnGATLALYg 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 288 ---LLP---KFDPQTVLKVLSSYPinSLVGApliYRMLLQQDLSRYKFPHLHSCYTGGESLLPETLEnWKAKTGLYIR-- 359
Cdd:PLN03051 193 gapLGRgfgKFVQDAGVTVLGLVP--SIVKA---WRHTGAFAMEGLDWSKLRVFASTGEASAVDDVL-WLSSVRGYYKpv 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 360 -EFYGQTETGLTCRISRTMTVK-PGSLGTAVPHYDVQVIDEQGNVLPPGKE--GDIAIRVkPFrpIGIFSGYV--DNPK- 432
Cdd:PLN03051 267 iEYCGGTELASGYISSTLLQPQaPGAFSTASLGTRFVLLNDNGVPYPDDQPcvGEVALAP-PM--LGASDRLLnaDHDKv 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 433 ---------KTEANIRGDfwllGDRGTKDPEGYFHFIGRTDDIINSSGTsfcryRIGPSEVENALME-HPAVAETVVISS 502
Cdd:PLN03051 344 yykgmpmygSKGMPLRRH----GDIMKRTPGGYFCVQGRADDTMNLGGI-----KTSSVEIERACDRaVAGIAETAAVGV 414
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 503 PDPTRGE----VVKAFVVLAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK 572
Cdd:PLN03051 415 APPDGGPellvIFLVLGEEKKGFDQARPEALQKKFQEAIQTNLNPLFKVSRVKIVPELPRNASNKLLRRVLRDQ 488
|
|
| FCS |
cd05921 |
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ... |
53-519 |
5.29e-09 |
|
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.
Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 58.98 E-value: 5.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 53 HWANmekagKRPPRPALWWMNGSGEELKWNFRELSEISQRAANVLSgPCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLV 132
Cdd:cd05921 3 HWAR-----QAPDRTWLAEREGNGGWRRVTYAEALRQVRAIAQGLL-DLGLSAERPLLILSGNSIEHALMALAAMYAGVP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 133 FMPGTIQ--MKSTDiLYRLQSS----KARAIVA--GDEVAQEVDAVAPDcsflKIKLLVSDNRREG--WLNFKTLLK--- 199
Cdd:cd05921 77 AAPVSPAysLMSQD-LAKLKHLfellKPGLVFAqdAAPFARALAAIFPL----GTPLVVSRNAVAGrgAISFAELAAtpp 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 200 --DVSNTHHcvETGSHEPAAIYFTSGTSGLPKMAEHSHSSLGLKAKMDADSWTGLNVSDTVwtisdtgwIVNILtsfleP 277
Cdd:cd05921 152 taAVDAAFA--AVGPDTVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTYPFFGEEPPV--------LVDWL-----P 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 278 W--TLGACVFVYLL-----------PKFDPQ---TVLKVLSSYPINSLVGAPLIYRML---LQQD--LSRYKFPHLHSCY 336
Cdd:cd05921 217 WnhTFGGNHNFNLVlynggtlyiddGKPMPGgfeETLRNLREISPTVYFNVPAGWEMLvaaLEKDeaLRRRFFKRLKLMF 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 337 TGGESLLPETlenWKAKTGLYIREF---------YGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVIdeqgnvlPPGk 407
Cdd:cd05921 297 YAGAGLSQDV---WDRLQALAVATVgeripmmagLGATETAPTATFTHWPTERSGLIGLPAPGTELKLV-------PSG- 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 408 eGDIAIRVK-PfrpiGIFSGYVDNPKKTEANIRGD-FWLLGDRG----TKDPEGYFHFIGR-TDDIINSSGTSFcryRIG 480
Cdd:cd05921 366 -GKYEVRVKgP----NVTPGYWRQPELTAQAFDEEgFYCLGDAAkladPDDPAKGLVFDGRvAEDFKLASGTWV---SVG 437
|
490 500 510
....*....|....*....|....*....|....*....
gi 2025697431 481 PSEVENALMEHPAVAEtVVISSPDptrGEVVKAFVVLAP 519
Cdd:cd05921 438 PLRARAVAACAPLVHD-AVVAGED---RAEVGALVFPDL 472
|
|
| A_NRPS_MycA_like |
cd05908 |
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ... |
383-570 |
1.53e-08 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 57.11 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 383 SLGTAVPHYDVQVIDEQGNVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWLL-GDRGTKDpEGYFHFIG 461
Cdd:cd05908 315 EVGKPIDETDIRICDEDNKILPDGYIGHIQIRGK-----NVTPGYYNNPEATAKVFTDDGWLKtGDLGFIR-NGRLVITG 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 462 RTDDIINSSGTSFcrYrigPSEVENALMEHPAV--AETVVISSPDP-TRGEVVKAFVVlapeflshdpdqltkllqqHVK 538
Cdd:cd05908 389 REKDIIFVNGQNV--Y---PHDIERIAEELEGVelGRVVACGVNNSnTRNEEIFCFIE-------------------HRK 444
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2025697431 539 SVTAPYKYPRKVEFVLD---------------LPKTITGKIERAKLR 570
Cdd:cd05908 445 SEDDFYPLGKKIKKHLNkrggwqinevlpirrIPKTTSGKVKRYELA 491
|
|
| A_NRPS_acs4 |
cd17654 |
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ... |
83-569 |
4.33e-08 |
|
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 55.56 E-value: 4.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISqraaNVLSGPCglQRGDRvAVVLSQVP--EWWLVTLGCIRTGLVFMPGTIQMKSTDILYRLQSSKARAIVAG 160
Cdd:cd17654 23 AEKISNLS----NFLRKKF--QTEER-AIGLRCDRgtESPVAILAILFLGAAYAPIDPASPEQRSLTVMKKCHVSYLLQN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 161 DEVAQEvdavapdcsflkiKLLVSDNRRegwlNFKTLLKdvsnthHCVetgshepAAIYFTSGTSGLPKMAEHSHSSL-- 238
Cdd:cd17654 96 KELDNA-------------PLSFTPEHR----HFNIRTD------ECL-------AYVIHTSGTTGTPKIVAVPHKCIlp 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 239 ---GLKAKMDADSwTGLNVSDTVWTISDTgwIVNILTSFLEpwtlGAC-VFVYLLPKFDPQTVLKVLSSYPINSLVGA-P 313
Cdd:cd17654 146 niqHFRSLFNITS-EDILFLTSPLTFDPS--VVEIFLSLSS----GATlLIVPTSVKVLPSKLADILFKRHRITVLQAtP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 314 LIYRMLLQQDLSRYKFPHLHSCYT---GGESLLPETLENWKAKTGLYIREF--YGQTET---GLTCRI-SRTMTVKPGS- 383
Cdd:cd17654 219 TLFRRFGSQSIKSTVLSATSSLRVlalGGEPFPSLVILSSWRGKGNRTRIFniYGITEVscwALAYKVpEEDSPVQLGSp 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 384 -LGTAVPHYDVQVIDEQGNVLPPGKegdiaIRVkpfrpiGIFSGYVDNPKkteanirGDFWLLGDRGTKDpEGYFHFIGR 462
Cdd:cd17654 299 lLGTVIEVRDQNGSEGTGQVFLGGL-----NRV------CILDDEVTVPK-------GTMRATGDFVTVK-DGELFFLGR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 463 TDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVISSPDptrgEVVKAFVVlapeflshDPDQLTKLLQQHVKSVTA 542
Cdd:cd17654 360 KDSQIKRRG-----KRINLDLIQQVIESCLGVESCAVTLSDQ----QRLIAFIV--------GESSSSRIHKELQLTLLS 422
|
490 500
....*....|....*....|....*..
gi 2025697431 543 PYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17654 423 SHAIPDTFVQIDKLPLTSHGKVDKSEL 449
|
|
| FACL_like_1 |
cd05910 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
83-500 |
5.33e-07 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 52.46 E-value: 5.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 83 FRELSEISQRAANVLSGpCGLQRGDRVAVVLSQVPEWWLVTLGCIRTGLVFM---PGtiqmkstdilyrlqsskaraiVA 159
Cdd:cd05910 5 FRELDERSDRIAQGLTA-YGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVlidPG---------------------MG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 160 GDEVAQEVDAVAPDcSFLKIKLlvsdnrregwlnfktllkdvsnthhcvetgSHEPAAIYFTSGTSGLPKMAEHSHSSLg 239
Cdd:cd05910 63 RKNLKQCLQEAEPD-AFIGIPK------------------------------ADEPAAILFTSGSTGTPKGVVYRHGTF- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 240 lKAKMDAdswtglnvsdtvwtISDTGWIVN---ILTSFLEPWTLGACVFVY-LLPKFD--------PQTVLKVLSSYPIN 307
Cdd:cd05910 111 -AAQIDA--------------LRQLYGIRPgevDLATFPLFALFGPALGLTsVIPDMDptrparadPQKLVGAIRQYGVS 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 308 SLVGAPLIYRML----LQQDLsryKFPHLHSCYTGGESLLPETLENWKA--KTGLYIREFYGQTETGLTCRI-------S 374
Cdd:cd05910 176 IVFGSPALLERVarycAQHGI---TLPSLRRVLSAGAPVPIALAARLRKmlSDEAEILTPYGATEALPVSSIgsrellaT 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 375 RTMTVKPGS---LGTAVPHYDVQVID---------EQGNVLPPGKEGDIAIRVKPFRPigifsGYVDNPKKTEA----NI 438
Cdd:cd05910 253 TTAATSGGAgtcVGRPIPGVRVRIIEiddepiaewDDTLELPRGEIGEITVTGPTVTP-----TYVNRPVATALakidDN 327
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025697431 439 RGDFW-LLGDRGTKDPEGYFHFIGRTDDIINSSGTSFcrYRIgpsEVENALMEHPAVAETVVI 500
Cdd:cd05910 328 SEGFWhRMGDLGYLDDEGRLWFCGRKAHRVITTGGTL--YTE---PVERVFNTHPGVRRSALV 385
|
|
| LC-FACS_euk |
cd05927 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ... |
216-499 |
1.00e-06 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 51.45 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 216 AAIYFTSGTSGLPKMAEHSHSSL-GLKAKMDaDSWTGLNVSDTVwtisdtgwivNILTSFL----------EPWTL--GA 282
Cdd:cd05927 117 ATICYTSGTTGNPKGVMLTHGNIvSNVAGVF-KILEILNKINPT----------DVYISYLplahifervvEALFLyhGA 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 283 CVFVY------LLPkfDPQTvLK--VLSSYP----------INSLVGAPLIYRMLLQQDLSrYKFPHL---HSCY----- 336
Cdd:cd05927 186 KIGFYsgdirlLLD--DIKA-LKptVFPGVPrvlnriydkiFNKVQAKGPLKRKLFNFALN-YKLAELrsgVVRAspfwd 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 337 -------------------TGGESLLPETLENWKAKTGLYIREFYGQTETGLTCRISRTMTVKPGSLGTAVPHYDVQVID 397
Cdd:cd05927 262 klvfnkikqalggnvrlmlTGSAPLSPEVLEFLRVALGCPVLEGYGQTECTAGATLTLPGDTSVGHVGGPLPCAEVKLVD 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 398 --EQG-NVLPPGKEGDIAIRVKpfrpiGIFSGYVDNPKKTEANIRGDFWLL-GDRGTKDPEGYFHFIGRTDDIINSSGTS 473
Cdd:cd05927 342 vpEMNyDAKDPNPRGEVCIRGP-----NVFSGYYKDPEKTAEALDEDGWLHtGDIGEWLPNGTLKIIDRKKNIFKLSQGE 416
|
330 340
....*....|....*....|....*.
gi 2025697431 474 FcryrIGPSEVENALMEHPAVAETVV 499
Cdd:cd05927 417 Y----VAPEKIENIYARSPFVAQIFV 438
|
|
| PRK09029 |
PRK09029 |
O-succinylbenzoic acid--CoA ligase; Provisional |
53-574 |
1.56e-06 |
|
O-succinylbenzoic acid--CoA ligase; Provisional
Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 50.64 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 53 HWANMekagkRPPRPALwwmNGSGEELKWnfRELSE-ISQRAANVLSGpcGLQRGDRVAVVLSQVPEWWLVTLGCIRTG- 130
Cdd:PRK09029 11 HWAQV-----RPQAIAL---RLNDEVLTW--QQLCArIDQLAAGFAQQ--GVVEGSGVALRGKNSPETLLAYLALLQCGa 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 131 --LVFMPGTIQMKSTDILYRLQsskaraivagdevaqeVDAVAPDCSFLKIKLLVSdnrregwlnfktLLKDVSNTHHCV 208
Cdd:PRK09029 79 rvLPLNPQLPQPLLEELLPSLT----------------LDFALVLEGENTFSALTS------------LHLQLVEGAHAV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 209 ETGSHEPAAIYFTSGTSGLPKMAEHSH-----SSLGLKAKMD---ADSW---------TGLNVsdtVWTisdtgWI---- 267
Cdd:PRK09029 131 AWQPQRLATMTLTSGSTGLPKAAVHTAqahlaSAEGVLSLMPftaQDSWllslplfhvSGQGI---VWR-----WLyaga 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 268 ---VNILTSFLEpwTLGACVFVYLLPkfdpqTVLKVLSSYPINSLVgaplIYRMLLqqdlsrykfphlhscytGGeSLLP 344
Cdd:PRK09029 203 tlvVRDKQPLEQ--ALAGCTHASLVP-----TQLWRLLDNRSEPLS----LKAVLL-----------------GG-AAIP 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 345 ETLENWKAKTGlyIREF--YGQTETGLT-C--RISRTMTVkpgslGTAVPHYDVQVIDeqgnvlppgkeGDIAIRVKpfr 419
Cdd:PRK09029 254 VELTEQAEQQG--IRCWcgYGLTEMASTvCakRADGLAGV-----GSPLPGREVKLVD-----------GEIWLRGA--- 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 420 piGIFSGYvdnpkkteanirgdfW-------LLGDRG---TKD----PEGYFHFIGRTDDIINSSGTSfcryrIGPSEVE 485
Cdd:PRK09029 313 --SLALGY---------------WrqgqlvpLVNDEGwfaTRDrgewQNGELTILGRLDNLFFSGGEG-----IQPEEIE 370
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 486 NALMEHPAVAETVVISSPDPTRGEVVKAFVvlapEFLShdpDQLTKLLQQHVKSVTAPYKYPrkVEFvLDLPKTI-TG-- 562
Cdd:PRK09029 371 RVINQHPLVQQVFVVPVADAEFGQRPVAVV----ESDS---EAAVVNLAEWLQDKLARFQQP--VAY-YLLPPELkNGgi 440
|
570
....*....|..
gi 2025697431 563 KIERAKLraKEW 574
Cdd:PRK09029 441 KISRQAL--KEW 450
|
|
| PLN02736 |
PLN02736 |
long-chain acyl-CoA synthetase |
337-513 |
2.01e-05 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 178337 [Multi-domain] Cd Length: 651 Bit Score: 47.40 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 337 TGGESLLPETLENWKAKTGLYIREFYGQTETglTCRISRTMT--VKPGSLGTAVPHYDVQVID----EQGNVLPPGKEGD 410
Cdd:PLN02736 383 SGASPLSPDVMEFLRICFGGRVLEGYGMTET--SCVISGMDEgdNLSGHVGSPNPACEVKLVDvpemNYTSEDQPYPRGE 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 411 IAIRvkpfRPIgIFSGYVDNPKKTEANIRGDFWL-LGDRGTKDPEGYFHFIGRTDDIINSSGTSFcryrIGPSEVENALM 489
Cdd:PLN02736 461 ICVR----GPI-IFKGYYKDEVQTREVIDEDGWLhTGDIGLWLPGGRLKIIDRKKNIFKLAQGEY----IAPEKIENVYA 531
|
170 180 190
....*....|....*....|....*....|....*
gi 2025697431 490 EHPAVAET-----------VVISSPDPtrgEVVKA 513
Cdd:PLN02736 532 KCKFVAQCfvygdslnsslVAVVVVDP---EVLKA 563
|
|
| PLN02430 |
PLN02430 |
long-chain-fatty-acid-CoA ligase |
337-574 |
3.24e-05 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 46.73 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 337 TGGESLLPETLENWKAKTGLYIREFYGQTET--GLTCRISRTMTVKpGSLGTAVPHYDVQV--IDEQG-NVLPPGKEGDI 411
Cdd:PLN02430 390 SGGAPLSTEIEEFLRVTSCAFVVQGYGLTETlgPTTLGFPDEMCML-GTVGAPAVYNELRLeeVPEMGyDPLGEPPRGEI 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 412 AIRVKPFrpigiFSGYVDNPKKTEANIRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGTSFcryrIGPSEVENALMEH 491
Cdd:PLN02430 469 CVRGKCL-----FSGYYKNPELTEEVMKDGWFHTGDIGEILPNGVLKIIDRKKNLIKLSQGEY----VALEYLENVYGQN 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 492 PAVAETVVISspDPTRGEVVkAFVVLAPEFLSHDPDqltklLQQHVKSVTAPYKYPRKVEFVLDLPKTITgkiERAKLRA 571
Cdd:PLN02430 540 PIVEDIWVYG--DSFKSMLV-AVVVPNEENTNKWAK-----DNGFTGSFEELCSLPELKEHILSELKSTA---EKNKLRG 608
|
...
gi 2025697431 572 KEW 574
Cdd:PLN02430 609 FEY 611
|
|
| A_NRPS_alphaAR |
cd17647 |
Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ... |
438-569 |
4.68e-03 |
|
Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as alpha-aminoadipate reductase (EC 1.2.1.95) or alpha-AR or L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), which catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.
Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 39.81 E-value: 4.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025697431 438 IRGDFWLLGDRGTKDPEGYFHFIGRTDDIINSSGtsfcrYRIGPSEVENALMEHPAVAETVVIS--------------SP 503
Cdd:cd17647 369 PRDRLYRTGDLGRYLPNGDCECCGRADDQVKIRG-----FRIELGEIDTHISQHPLVRENITLVrrdkdeeptlvsyiVP 443
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025697431 504 DPTRGEVVKAFVVLAPEFLSHDP--------DQLTKLLQQHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKL 569
Cdd:cd17647 444 RFDKPDDESFAQEDVPKEVSTDPivkgligyRKLIKDIREFLKKRLASYAIPSLIVVLDKLPLNPNGKVDKPKL 517
|
|
| |
