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Conserved domains on  [gi|1985396033|ref|XP_039338717|]
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rho GTPase-activating protein 19 isoform X1 [Mauremys reevesii]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138218)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP; similar to mammalian rho GTPase-activating protein 19 (ARHGAP19), which participates in various cytoskeletal-related events, including epithelial morphogenesis

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-331 4.73e-119

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239857  Cd Length: 208  Bit Score: 348.30  E-value: 4.73e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLTEEGIAQVSQLIEYLHKHLRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLL 203
Cdd:cd04392     1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 204 THKHFQAHLKIAGLMQFDDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFA 283
Cdd:cd04392    81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1985396033 284 PHILWPRNVTANDLQENITKLNDGVAFMIKHSQKLFKAPAYIRECARL 331
Cdd:cd04392   161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-331 4.73e-119

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 348.30  E-value: 4.73e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLTEEGIAQVSQLIEYLHKHLRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLL 203
Cdd:cd04392     1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 204 THKHFQAHLKIAGLMQFDDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFA 283
Cdd:cd04392    81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1985396033 284 PHILWPRNVTANDLQENITKLNDGVAFMIKHSQKLFKAPAYIRECARL 331
Cdd:cd04392   161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 136-315 2.40e-37

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 135.47  E-value: 2.40e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033  136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKI 214
Cdd:smart00324   7 VEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFIEA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033  215 AglmqfddkgnktSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTA 294
Cdd:smart00324  87 A------------KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV 154

                          170       180
                   ....*....|....*....|.
gi 1985396033  295 NDLQEnITKLNDGVAFMIKHS 315
Cdd:smart00324 155 ASLKD-IRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 136-291 3.84e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 131.13  E-value: 3.84e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKI 214
Cdd:pfam00620   4 VRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1985396033 215 AglmqfddkgnktSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRN 291
Cdd:pfam00620  84 A------------KLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-331 4.73e-119

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 348.30  E-value: 4.73e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLTEEGIAQVSQLIEYLHKHLRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLL 203
Cdd:cd04392     1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 204 THKHFQAHLKIAGLMQFDDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFA 283
Cdd:cd04392    81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1985396033 284 PHILWPRNVTANDLQENITKLNDGVAFMIKHSQKLFKAPAYIRECARL 331
Cdd:cd04392   161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 136-315 2.40e-37

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 135.47  E-value: 2.40e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033  136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKI 214
Cdd:smart00324   7 VEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFIEA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033  215 AglmqfddkgnktSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTA 294
Cdd:smart00324  87 A------------KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV 154

                          170       180
                   ....*....|....*....|.
gi 1985396033  295 NDLQEnITKLNDGVAFMIKHS 315
Cdd:smart00324 155 ASLKD-IRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 136-314 1.26e-36

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 133.20  E-value: 1.26e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESgEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKI 214
Cdd:cd00159     4 IEKCIEYLEKNgLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFELYDEFIEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 215 AGLMqfddkgnktstpDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTA 294
Cdd:cd00159    83 AKIE------------DEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDD 150

                         170       180
                  ....*....|....*....|
gi 1985396033 295 NDLqENITKLNDGVAFMIKH 314
Cdd:cd00159   151 ELL-EDIKKLNEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 136-291 3.84e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 131.13  E-value: 3.84e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKI 214
Cdd:pfam00620   4 VRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1985396033 215 AglmqfddkgnktSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRN 291
Cdd:pfam00620  84 A------------KLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 111-325 5.64e-27

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 108.20  E-value: 5.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 111 SLMSLKRKDKGVVFGS--PLteegIAQvsQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNS---GADIDLESgeFHS 184
Cdd:cd04391     5 PLSTLLERDQKKVPGSkvPL----IFQ--KLINKLEERgLETEGILRIPGSAQRVKFLCQELEAkfyEGTFLWDQ--VKQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 185 NDVASLLKMFLGELPEPLLTHKHFQAHLKIAGLmqfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQT 264
Cdd:cd04391    77 HDAASLLKLFIRELPQPLLTVEYLPAFYSVQGL------------PSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKV 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1985396033 265 AKKQDKNKMSAHNLALMFAPHILWPRNVTANDLQENITKLNDGVA------FMIKHSQKLFKAPAYI 325
Cdd:cd04391   145 VDHEEKNKMNLWNVAMIMAPNLFPPRGKHSKDNESLQEEVNMAAGcanimrLLIRYQDLLWTVPSFL 211
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-319 2.17e-23

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 97.41  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLT--------EEGIAQ-VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESgefhSNDV---ASL 190
Cdd:cd04404     6 FGVSLQflkeknpeQEPIPPvVRETVEYLQAHaLTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQ----YEDVhlpAVI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 191 LKMFLGELPEPLLThkhFQAHLKIAGLmqfddkgnktSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDK 270
Cdd:cd04404    82 LKTFLRELPEPLLT---FDLYDDIVGF----------LNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1985396033 271 NKMSAHNLALMFAPHILWPRNVTANdlQENITKLNDGVAFMIKHSQKLF 319
Cdd:cd04404   149 NKMTNSNLAVVFGPNLLWAKDASMS--LSAINPINTFTKFLLDHQDEIF 195
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-287 1.89e-22

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 95.23  E-value: 1.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPL--------TEEG-IAQ-VSQLIEYLHKHLRMEGLFRVPGNSLRQQILKDALNSGADIDlesGEFHSNDVASLLK 192
Cdd:cd04394     1 VFGVPLhslphstvPEYGnVPKfLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL---SSALPCDVAGLLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 193 MFLGELPEPLLTHKHFQAHLKIAGLmqfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNK 272
Cdd:cd04394    78 QFFRELPEPLLPYDLHEALLKAQEL------------PTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENK 145

                         170
                  ....*....|....*
gi 1985396033 273 MSAHNLALMFAPHIL 287
Cdd:cd04394   146 MDSSNLAVIFAPNLF 160
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 135-325 2.32e-22

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 94.81  E-value: 2.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 135 QVSQLIE----YLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESgEFHSNDVASLLKMFLGELPEPLLTHKHFQ 209
Cdd:cd04376     8 QVPRLVEsccqHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDE-NHSVHDVAALLKEFFRDMPDPLLPRELYT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 210 AHLKIAGLmqfddkgnktstpDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDK-----------NKMSAHNL 278
Cdd:cd04376    87 AFIGTALL-------------EPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNL 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1985396033 279 ALMFAPHIL-------WPRNVTANDLQENITKLNDgVAFMIKHSQKLFKAPAYI 325
Cdd:cd04376   154 ATIFGPNLLhkqksgeREFVQASLRIEESTAIINV-VQTMIDNYEELFMVSPEL 206
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-319 8.61e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 93.29  E-value: 8.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPL------TEEGIAQVSQL-IEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSG---ADIDLESGEFHSndVASLL 191
Cdd:cd04386     4 VFGTPLeehlkrTGREIALPIEAcVMCLLETgMNEEGLFRVGGGASKLKRLKAALDAGtfsLPLDEFYSDPHA--VASAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLTHKHFQAHLKIAGLmqfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04386    82 KSYLRELPDPLLTYNLYEDWVQAANK------------PDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDEN 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1985396033 272 KMSAHNLALMFAPHILWPRNVTANDLQE--NITKLNDGVAFMIKHSQKLF 319
Cdd:cd04386   150 KMSPSNIAIVLAPNLLWAKNEGSLAEMAagTSVHVVAIVELIISHADWFF 199
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 121-313 4.59e-21

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 90.58  E-value: 4.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 121 GVVFGSPLTEEgiAQVSQLIEYLHKHLRM-----EGLFRVPGNSLRQQILKDALNSGAD-IDLESGEFHSndVASLLKMF 194
Cdd:cd04377     2 GVSLSSLTSED--RSVPLVLEKLLEHIEMhglytEGIYRKSGSANKIKELRQGLDTDPDsVNLEDYPIHV--ITSVLKQW 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 195 LGELPEPLLTHKHFQAHLKIAGLmqfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMS 274
Cdd:cd04377    78 LRELPEPLMTFELYENFLRAMEL------------EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMS 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1985396033 275 AHNLALMFAPHIL-WPRNVTANDLQENITKLNDGVAFMIK 313
Cdd:cd04377   146 ANALAIVFAPCILrCPDTADPLQSLQDVSKTTTCVETLIK 185
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 146-319 3.41e-20

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 88.51  E-value: 3.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 146 HLRM-----EGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSndVASLLKMFLGELPEPLLTHKHFQAHLKIAglmqf 220
Cdd:cd04402    25 LLYQkgpstEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLL--LASVLKDFLRNIPGSLLSSDLYEEWMSAL----- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 221 ddkgnktSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTA--NDLQ 298
Cdd:cd04402    98 -------DQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPPASSElqNEDL 170

                         170       180
                  ....*....|....*....|.
gi 1985396033 299 ENITKLndgVAFMIKHSQKLF 319
Cdd:cd04402   171 KKVTSL---VQFLIENCQEIF 188
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-324 1.63e-18

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 84.39  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPL------TEEGIAQ-VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEfHSNDVASLLKMF 194
Cdd:cd04375     4 VFGVPLlvnlqrTGQPLPRsIQQAMRWLRNNaLDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQ-QAYDVADMLKQY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 195 LGELPEPLLTHKHFQAHLKIaglMQFddkgnktsTPDKERqIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMS 274
Cdd:cd04375    83 FRDLPEPLLTNKLSETFIAI---FQY--------VPKEQR-LEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMT 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 275 AHNLALMFAP---HILWPRNVTAN-----------------DLQENITKlNDGVAFMIKHSQKLFKAPAY 324
Cdd:cd04375   151 ATNLAVCLAPslfHLNTSRRENSSparrmqrkkslgkpdqkELSENKAA-HQCLAYMIEECNTLFMVPKE 219
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 140-294 2.36e-18

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 83.24  E-value: 2.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 140 IEylHKHLRMEGLFRVPGNSLRQQILKDALNSGADIdLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKIAGLMQ 219
Cdd:cd04378    27 IE--NRALGVQGIYRVSGSKARVEKLCQAFENGKDL-VELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALAKEIQ 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1985396033 220 FDDKGNK--TSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTA 294
Cdd:cd04378   104 RDTEEDKapNTPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLIRPRPGDA 180
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-286 3.75e-18

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 82.51  E-value: 3.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPL--------TEEGI-AQVSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDL-ESGEFHSndVASLL 191
Cdd:cd04393     2 VFGVPLqelqqagqPENGVpAVVRHIVEYLEQHgLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLsKEADVCS--AASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLThkhfqAHLKIAgLMQFDDKGNKtstpdKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04393    80 RLFLQELPEGLIP-----ASLQIR-LMQLYQDYNG-----EDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHEN 148

                         170
                  ....*....|....*
gi 1985396033 272 KMSAHNLALMFAPHI 286
Cdd:cd04393   149 RMTAENLAAVFGPDV 163
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 142-318 1.00e-17

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 82.07  E-value: 1.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 142 YLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADI--DLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKI---- 214
Cdd:cd04396    42 YLKENaTEVEGIFRVAGSSKRIRELQLIFSTPPDYgkSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPlrkr 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 215 -AGLMQFDDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILW-PRnv 292
Cdd:cd04396   122 pRILQYMKGRINEPLNTDIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILShPD-- 199

                         170       180
                  ....*....|....*....|....*..
gi 1985396033 293 taNDLQENITKLNDGVA-FMIKHSQKL 318
Cdd:cd04396   200 --HEMDPKEYKLSRLVVeFLIEHQDKF 224
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 136-295 2.28e-17

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 80.13  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHSNDVAS-LLKMFLGELPEPLLTHKHFQahlk 213
Cdd:cd04403    20 VRLCIEAVEKRgLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKWEDIHVITgALKLFFRELPEPLFPYSLFN---- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 214 iaglmqfdDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVT 293
Cdd:cd04403    96 --------DFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLLRPEQET 167


                  ..
gi 1985396033 294 AN 295
Cdd:cd04403   168 GN 169
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 136-319 3.96e-17

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 79.79  E-value: 3.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGadidlESGEFHSND----VASLLKMFLGELPEPLLTHKHFQA 210
Cdd:cd04390    26 VEQCVDFIREHgLKEEGLFRLPGQANLVKQLQDAFDAG-----ERPSFDSDTdvhtVASLLKLYLRELPEPVIPWAQYED 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 211 HLKIAGLMqfddkgnktsTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPR 290
Cdd:cd04390   101 FLSCAQLL----------SKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPK 170

                         170       180
                  ....*....|....*....|....*....
gi 1985396033 291 NVTANDLQENITKLNDGVAFMIKHSQKLF 319
Cdd:cd04390   171 VEDPATIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 121-287 5.67e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 78.88  E-value: 5.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 121 GVVFGSPLTEEgiAQVSQLIEYLHKHLRM-----EGLFRVPGNSLRQQILKDALNSG-ADIDLESGEFHSndVASLLKMF 194
Cdd:cd04407     2 GVRVGSLTSNK--TSVPIVLEKLLEHVEMhglytEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHA--ITGLLKQW 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 195 LGELPEPLLTHKHFQAHLKIAGLmqfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMS 274
Cdd:cd04407    78 LRELPEPLMTFAQYNDFLRAVEL------------PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMS 145

                         170
                  ....*....|...
gi 1985396033 275 AHNLALMFAPHIL 287
Cdd:cd04407   146 PNALAIVFAPCLL 158
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 136-284 6.84e-17

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 78.50  E-value: 6.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLR-QQIL----KDALNsgadIDLESGEFHSNDVASLLKMFLGELPEPLLThKHFQ 209
Cdd:cd04385    19 VDKCIDFITQHgLMSEGIYRKNGKNSSvKKLLeafrKDARS----VQLREGEYTVHDVADVLKRFLRDLPDPLLT-SELH 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1985396033 210 AHLKIAglmqfddkgnkTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAP 284
Cdd:cd04385    94 AEWIEA-----------AELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGP 157
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 147-294 1.11e-16

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 78.70  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 147 LRMEGLFRVPGNSLRQQILKDALNSGADIdLESGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLKIAGLMQFDDKGNK 226
Cdd:cd04409    32 LCLKGIYRVNGAKSRVEKLCQAFENGKDL-VELSELSPHDISNVLKLYLRQLPEPLILFRLYNEFIGLAKESQHVNETQE 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1985396033 227 T-STPDKERQ---IEALQLLFLI------LPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTA 294
Cdd:cd04409   111 AkKNSDKKWPnmcTELNRILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNLGIIFGPTLIRPRPTDA 188
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-291 4.51e-16

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 76.67  E-value: 4.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPLTEEGIAQVSQLIEYL---------HKHLRMEGLFRVPGNSLRQQILKDALNSGA-DIDLESGEFHS-NDVASLL 191
Cdd:cd04395     1 TFGVPLDDCPPSSENPYVPLIvevccniveARGLETVGIYRVPGNNAAISALQEELNRGGfDIDLQDPRWRDvNVVSSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLTHKHFQAHLKiaglmqfddkGNKTSTPdKERQIEaLQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04395    81 KSFFRKLPEPLFTNELYPDFIE----------ANRIEDP-VERLKE-LRRLIHSLPDHHYETLKHLIRHLKTVADNSEVN 148

                         170       180
                  ....*....|....*....|
gi 1985396033 272 KMSAHNLALMFAPHILWPRN 291
Cdd:cd04395   149 KMEPRNLAIVFGPTLVRTSD 168
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-287 8.25e-16

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 75.90  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLTE----EGI---AQVSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDAL-NSGADIDLESGEFHSND---VASLL 191
Cdd:cd04398     1 FGVPLEDlilrEGDnvpNIVYQCIQAIENFgLNLEGIYRLSGNVSRVNKLKELFdKDPLNVLLISPEDYESDihsVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLTHKHFQAhlkiaglmqFDDKGNKTstpDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04398    81 KLFFRELPEPLLTKALSRE---------FIEAAKIE---DESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVN 148

                         170
                  ....*....|....*.
gi 1985396033 272 KMSAHNLALMFAPHIL 287
Cdd:cd04398   149 RMSVNNLAIIWGPTLM 164
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 136-289 3.24e-15

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 74.19  E-value: 3.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGA-DIDLESGEFHSNDVASLLKMFLGELPEPLLTHKHFqahLK 213
Cdd:cd04387    20 VRQCVEEVERRgMEEVGIYRISGVATDIQALKAAFDTNNkDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY---PN 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985396033 214 IAGLMQFDDKGNKTStpdkerqieALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWP 289
Cdd:cd04387    97 FAEGIALSDPVAKES---------CMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRP 163
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 145-325 5.29e-15

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 73.94  E-value: 5.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 145 KHLRMEGLFRVPGNSLRQQILKDALNSGADidlESGEFHSNDV---ASLLKMFLGELPEPLLT---HKHFQAHLKIaglm 218
Cdd:cd04397    41 MDMSVEGVFRKNGNIRRLKELTEEIDKNPT---EVPDLSKENPvqlAALLKKFLRELPDPLLTfklYRLWISSQKI---- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 219 qfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAK-----KQDKNKMSAHNLALMFAPHILWPRNvT 293
Cdd:cd04397   114 -----------EDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSfshidEETGSKMDIHNLATVITPNILYSKT-D 181

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1985396033 294 ANDLQENITKLNDGVAFMIKHSQKLFKAPAYI 325
Cdd:cd04397   182 NPNTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 141-289 1.61e-14

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 72.16  E-value: 1.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 141 EYLHKHLRMEGLFRVPGNSLRQQILKDALNSGAD-IDLESGEFHsnDVASLLKMFLGELPEPLLTHKHFQAHLKIAGLMQ 219
Cdd:cd04408    26 EIENRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSGHSPH--DITSVLKHFLKELPEPVLPFQLYDDFIALAKELQ 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 220 FDDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWP 289
Cdd:cd04408   104 RDSEKAAESPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLRP 173
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 123-302 2.20e-14

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 71.62  E-value: 2.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPLtEEGIAQVSQ-------------LIEYLHKH--LRMEGLFRVPGNSLRQQILKDALNSGADIDL-ESGEFHS-N 185
Cdd:cd04400     1 IFGSPL-EEAVELSSHkyngrdlpsvvyrCIEYLDKNraIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfSSSLYPDvH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 186 DVASLLKMFLGELPEPLLT---HKHFQAHLKIaglmqfddkgnktsTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLY 262
Cdd:cd04400    80 TVAGLLKLYLRELPTLILGgelHNDFKRLVEE--------------NHDRSQRALELKDLVSQLPQANYDLLYVLFSFLR 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1985396033 263 QTAKKQDKNKMSAHNLALMFAPHIlwprNVTANDLQENIT 302
Cdd:cd04400   146 KIIEHSDVNKMNLRNVCIVFSPTL----NIPAGIFVLFLT 181
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-289 1.01e-13

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 69.41  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLTEEGIAQ------VSQLIEYLHKH-LRMEGLFRVPGN-----SLRQQILKDalnsgADIDLESGEFHSNDVASLL 191
Cdd:cd04373     1 FGVPLANVVTSEkpipifLEKCVEFIEATgLETEGIYRVSGNkthldSLQKQFDQD-----HNLDLVSKDFTVNAVAGAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLTHKHFQAHLKIAGLmqfddkgnktstPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04373    76 KSFFSELPDPLIPYSMHLELVEAAKI------------NDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVN 143

                         170
                  ....*....|....*...
gi 1985396033 272 KMSAHNLALMFAPHILWP 289
Cdd:cd04373   144 LMTSENLSICFWPTLMRP 161
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 124-284 1.41e-12

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 66.30  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 124 FGSPLTE--------EGI---AQVSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLEsgEFHSNDVASLL 191
Cdd:cd04381     1 FGASLSLaversrchDGIdlpLVFRECIDYVEKHgMKCEGIYKVSGIKSKVDELKAAYNRRESPNLE--EYEPPTVASLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLTHKHfqahlkiagLMQFDDKGNKTSTPDKERQieaLQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04381    79 KQYLRELPEPLLTKEL---------MPRFEEACGRPTEAEREQE---LQRLLKELPECNRLLLAWLIVHMDHVIAQELET 146

                         170
                  ....*....|...
gi 1985396033 272 KMSAHNLALMFAP 284
Cdd:cd04381   147 KMNIQNISIVLSP 159
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 114-293 6.11e-12

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 64.72  E-value: 6.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 114 SLKRKDKGVVFGSPLTEEGIAQVSQLIEYLH-KHLRMEGLFRVPGNSLRQQILkdaLNSG--------ADIDLESGEFHS 184
Cdd:cd04374    10 SPGRLQSEVEGEAQLDDIGFKFVRKCIEAVEtRGINEQGLYRVVGVNSKVQKL---LSLGldpktstpGDVDLDNSEWEI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 185 NDVASLLKMFLGELPEPLLThkhFQAHlkiaglmqfDDKGNKTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQT 264
Cdd:cd04374    87 KTITSALKTYLRNLPEPLMT---YELH---------NDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNV 154

                         170       180
                  ....*....|....*....|....*....
gi 1985396033 265 AKKQDKNKMSAHNLALMFAPHILWPRNVT 293
Cdd:cd04374   155 SDHSKKNLMTVSNLGVVFGPTLLRPQEET 183
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-290 3.72e-11

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 62.52  E-value: 3.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 123 VFGSPLTE------EGIAQVSQ-LIEYLHKHLRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEF----HSndVASLL 191
Cdd:cd04384     2 VFGCDLTEhllnsgQDVPQVLKsCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYiqdiHS--VSSLC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 192 KMFLGELPEPLLThkhFQAHLKIAGLMQFDdkgnktstPDKERqIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 271
Cdd:cd04384    80 KLYFRELPNPLLT---YQLYEKFSEAVSAA--------SDEER-LEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSIT 147

                         170
                  ....*....|....*....
gi 1985396033 272 KMSAHNLALMFAPHILWPR 290
Cdd:cd04384   148 NMHAKNLAIVWAPNLLRSK 166
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 147-319 6.97e-11

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 61.38  E-value: 6.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 147 LRMEGLFRVPGNSLRQQILKDALN-SGADIDLESGEFHS-NDVASLLKMFLGELPEPLLThkhFQAHLKIAGLMQfddkg 224
Cdd:cd04372    32 LQSEGLYRVSGFAEEIEDVKMAFDrDGEKADISATVYPDiNVITGALKLYFRDLPIPVIT---YDTYPKFIDAAK----- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 225 nktsTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTANDLQENITKL 304
Cdd:cd04372   104 ----ISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSALTTLNDMRYQ 179

                         170
                  ....*....|....*
gi 1985396033 305 NDGVAFMIKHSQKLF 319
Cdd:cd04372   180 ILIVQLLITNEDVLF 194
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 136-287 3.64e-09

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 56.16  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGAD-IDLESGEFHSndVASLLKMFLGELPEPLLTHKHFQAHLK 213
Cdd:cd04406    19 VEKLINYIEMHgLYTEGIYRKSGSTNKIKELRQGLDTDANsVNLDDYNIHV--IASVFKQWLRDLPNPLMTFELYEEFLR 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1985396033 214 IAGLMqfddkgnktstpDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHIL 287
Cdd:cd04406    97 AMGLQ------------ERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCIL 158
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 147-286 1.18e-08

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 54.99  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 147 LRMEGLFRVPGNSLRQQILKDALNSGADI-DLesGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLkiaglmqfddkgN 225
Cdd:cd04382    33 LTEEGLYRVSGSEREVKALKEKFLRGKTVpNL--SKVDIHVICGCLKDFLRSLKEPLITFALWKEFM------------E 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1985396033 226 KTSTPDKERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDkNKMSAHNLALMFAPHI 286
Cdd:cd04382    99 AAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGPTI 158
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 148-314 1.64e-08

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 54.32  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 148 RMEGLFRVPG-----NSLRQQIlkdalnSGADIDLeSGEFHSNDVASLLKMFLGELPEPLLTHKHFQAHLkiaglmqfdd 222
Cdd:cd04389    39 QTEGIFRVPGdidevNELKLRV------DQWDYPL-SGLEDPHVPASLLKLWLRELEEPLIPDALYQQCI---------- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 223 kgNKTSTPDKerQIEALQLLflilPPPNRNLLKLLLDLLYQTAKKQ--DKNKMSAHNLALMFAPHILWPRNVTANDLQEN 300
Cdd:cd04389   102 --SASEDPDK--AVEIVQKL----PIINRLVLCYLINFLQVFAQPEnvAHTKMDVSNLAMVFAPNILRCTSDDPRVIFEN 173

                         170
                  ....*....|....
gi 1985396033 301 ITKLNDGVAFMIKH 314
Cdd:cd04389   174 TRKEMSFLRTLIEH 187
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 136-287 4.80e-07

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 50.11  E-value: 4.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 136 VSQLIEYLHKH-LRMEGLFRVPGNSLRQQILKDALNSGADIDLESGEFHS-NDVASLLKMFLGELPEPLLTHKHFQahlk 213
Cdd:cd04383    22 VESCIRFINLYgLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNDHDiNSVAGVLKLYFRGLENPLFPKERFE---- 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1985396033 214 iaglmQFDDKGNKTSTPDKERQIealQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHIL 287
Cdd:cd04383    98 -----DLMSCVKLENPTERVHQI---REILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLM 163
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 147-290 6.10e-07

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 50.16  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 147 LRMEGLFRVPGNSLRQQILKDALNSG-ADIDLESGEF-HSNDVASLLKMFLGELPEPLLTHKHFQAHLKIAGLMQFDDKg 224
Cdd:cd04379    34 LDVIGLYRLCGSAAKKKELRDAFERNsAAVELSEELYpDINVITGVLKDYLRELPEPLITPQLYEMVLEALAVALPNDV- 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985396033 225 nKTSTPDKERQIEALQLLflilpppNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPR 290
Cdd:cd04379   113 -QTNTHLTLSIIDCLPLS-------AKATLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMFCS 170
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 196-326 5.22e-06

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 47.71  E-value: 5.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 196 GELPEPLLTHKHFQAHLKIAGLMQfddkGNKTstpdkERQIEALQLLFLILPPPNRNLLKLLLDLLYQTAK-------KQ 268
Cdd:cd04405   117 GQLKEPLLTFHLFDIFVGILELLG----NGKE-----EVALEALQLCLLLLPPASRRELRRLLRFMARAAKndmprlhKE 187

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1985396033 269 DKNKMsahNLALMFAPHILWPRNVTANdlqeNITKLndgVAFMIKHSQKLFKAPAYIR 326
Cdd:cd04405   188 IENRM---LVKQTFSRAILCSKDLDEG----LADLL---VLFLMDHHQDIFKVPGSLH 235
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 138-287 2.04e-05

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 45.79  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985396033 138 QLIEYLHKH-LRMEGLFRVPGN-----SLRQQILkDALNSGADiDLESGEFHSndVASLLKMFLGELPEPLLThKHFQAH 211
Cdd:cd04380    56 RLVDYLYTRgLAQEGLFEEPGLpsepgELLAEIR-DALDTGSP-FNSPGSAES--VAEALLLFLESLPDPIIP-YSLYER 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985396033 212 LKIAGLMQFDDKgnktstpdkerqieaLQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHIL 287
Cdd:cd04380   131 LLEAVANNEEDK---------------RQVIRISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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