second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 253 RVGFGELPFDSTDNfSSCPDVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqTQPTIPVVTLHNISEDIFIRV 332
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1985392714 333 LYYIYSDDTELSPENAYDVLCVADMYLLPGLKRLCGRTLAQILD 376
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

Ankyrin repeat [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714   6 LFTSCKKGDVSRVRYLLEqRDVEINVRDKWDSTPLYYACLCGHEELVSYLLASGAKCEANTFDGERCLYGALSDAIRRVL 85
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                          90
                  ....*....|....*..
gi 1985392714  86 KEYKQITAKCMKRDYYD 102
Cdd:COG0666   236 KLLLEAGADLNAKDKDG 252

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 253 RVGFGELPFDSTDNfSSCPDVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqTQPTIPVVTLHNISEDIFIRV 332
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1985392714 333 LYYIYSDDTELSPENAYDVLCVADMYLLPGLKRLCGRTLAQILD 376
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 105 LQRLLEQGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRL--DIDV 182
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLisEENV 80

                          90       100
                  ....*....|....*....|....*...
gi 1985392714 183 EYVndckrLAKQCRLQdlIEDLEIKCKK 210
Cdd:pfam00651  81 DDL-----LAAADKLQ--IPSLVDKCEE 101

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714  116 DIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRLDIDVEYVNDCKRLAKQC 195
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*
gi 1985392714  196 RLQDLIEDLEIKCKK 210
Cdd:smart00225  81 QIPGLVELCEEFLLK 95

Ankyrin repeat [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714   6 LFTSCKKGDVSRVRYLLEqRDVEINVRDKWDSTPLYYACLCGHEELVSYLLASGAKCEANTFDGERCLYGALSDAIRRVL 85
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                          90
                  ....*....|....*..
gi 1985392714  86 KEYKQITAKCMKRDYYD 102
Cdd:COG0666   236 KLLLEAGADLNAKDKDG 252

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714   6 LFTSCKKGDVSRVRYLLEQRDVEINVRDKwdsTPLYYACLCGHEELVSYLLASGAKCEAN 65
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVNLKDNGR---TALHYAARSGHLEIVKLLLEKGADINVK 90

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 117 IVFIVHGKSFCAHRCILSARSVYFAEMFETKWKgKNMIALKHpliNPAAFGSLLQYLYTGRLDIDVEYVNDCKRLAKQCR 196
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFK-ENEINLNI---DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLI 89

                  ....*
gi 1985392714 197 LQDLI 201
Cdd:PHA03098   90 IDFLI 94

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 253 RVGFGELPFDSTDNfSSCPDVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqTQPTIPVVTLHNISEDIFIRV 332
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1985392714 333 LYYIYSDDTELSPENAYDVLCVADMYLLPGLKRLCGRTLAQILD 376
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 115 SDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRLDIDVEYVNDCKRLAKQ 194
Cdd:cd18186     2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                  .
gi 1985392714 195 C 195
Cdd:cd18186    82 L 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqtqptiPVVTLHNISEDIFIRVLYYIYSDDTELSPENAYDV 351
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSS-------SEIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                  ....*..
gi 1985392714 352 LCVADMY 358
Cdd:cd18186    76 LAAADKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 105 LQRLLEQGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRL--DIDV 182
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLisEENV 80

                          90       100
                  ....*....|....*....|....*...
gi 1985392714 183 EYVndckrLAKQCRLQdlIEDLEIKCKK 210
Cdd:pfam00651  81 DDL-----LAAADKLQ--IPSLVDKCEE 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFL--CHKAFFCGRSDYFKALLEDHFSESEelqtqPTIPVVtLHNISEDIFIRVLYYIYSDDTELSPENAY 349
Cdd:cd18294    16 DVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKES-----TQSPLV-LSDIEPEVFRAVLEFIYTNCVTLSNHTVI 89

                          90       100
                  ....*....|....*....|
gi 1985392714 350 DVLCVADMYLLPGLKRLCGR 369
Cdd:cd18294    90 EVLAAAVEYGLDELRKLCER 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqtqptiPVVTLHNISEDIFIRVLYYIYS---DDTELSPENA 348
Cdd:cd18297    14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-------PVIEIPDIRYDIFQLMMQYLYTggvESLDVAQDDA 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1985392714 349 YDVLCVADMYLLPGLKRLCGRTLAQILDEDN 379
Cdd:cd18297    87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEelqtqptIPVVTLHNISEDIFIRVLYYIYSDDTeLSPENAYDV 351
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESS-------VSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|....
gi 1985392714 352 LCVADMYLLPGLKRLCGRTLAQIL 375
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 107 RLLEQGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMF-----ETKwkgKNMIALKHplINPAAFGSLLQYLYTGRL--- 178
Cdd:cd18287    15 ALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmrESQ---QSEIELKD--TNAEAFKALLKYIYTGRLtlt 89

                          90       100
                  ....*....|....*....|..
gi 1985392714 179 DIDVEYVNDCKRLAKQCRLQDL 200
Cdd:cd18287    90 DLKEDVLLDVLGLAHQYGFEEL 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 116 DIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRLDIDVEYVNDCKRLAKQC 195
Cdd:cd18306    20 DVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKL 99

                  ....*..
gi 1985392714 196 RLQDLIE 202
Cdd:cd18306   100 KMDRVKK 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 105 LQRLLEQGYQSDIVFIV--HGKSFCAHRCILSARSVYFAEMFETkwkGKNMIALKHPLI----NPAAFGSLLQYLYTGRL 178
Cdd:cd18294     5 MKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLT---GPQKESTQSPLVlsdiEPEVFRAVLEFIYTNCV 81

                  ....*..
gi 1985392714 179 DIDVEYV 185
Cdd:cd18294    82 TLSNHTV 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 105 LQRLLEQGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKG---KNMIALKHPLINPAAFGSLLQYLYTGRLDID 181
Cdd:cd18292     8 IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSeskQSEIELVEDPECAAVFEKFLRYLYTGQISVN 87

                          90       100
                  ....*....|....*....|.
gi 1985392714 182 VEYVNDCKRLAKQCRLQDLIE 202
Cdd:cd18292    88 LETALPLLMLADKYNVTDLKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqtqptiPVVTLHNISEDIFIRVLYYIYSDDTELSPENAYDV 351
Cdd:cd18256    22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK-------DVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQEL 94

                          90       100       110
                  ....*....|....*....|....*....|
gi 1985392714 352 LCVADMYLLPGLKRLCGRTLAQILDEDNVV 381
Cdd:cd18256    95 LVAADMLQLTEVVEICCEFLKGQLHPSNCI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 100 YYDVFLQRLLEQGYQ---SDIVFIVHGKSFCAHRCILSARSVYFAEMFETkwkgknmiALKHPL-----INPAAFGSLLQ 171
Cdd:cd18221     1 HYKVMLDRLNEQRELdqfTDITLIVDGHQFKAHKAVLAACSQFFYKFFQD--------FTQEPLveiegVSNMAFRHLIE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1985392714 172 YLYTGRLDI-DVEYVNDCKRLAKQCRLQDLIEDLEIKCKK 210
Cdd:cd18221    73 FTYTAKLMVqGEEEANDVWKAAEYLQMQEAIKALEFRNKE 112

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 115 SDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRLDIDVEYVNDCKRLAKQ 194
Cdd:cd18352    14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQ 93

                          90
                  ....*....|....*
gi 1985392714 195 CrlqdLIEDLEIKCK 209
Cdd:cd18352    94 Y----LLEGLKRLCE 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 256 FGELpFDSTDnFSscpDVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEELQtqptipvVTLHNISEDIFIRVLYY 335
Cdd:cd18287    13 IGAL-FLNEE-YS---DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSE-------IELKDTNAEAFKALLKY 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1985392714 336 IYS---DDTELSPENAYDVLCVADMYLLPGLK 364
Cdd:cd18287    81 IYTgrlTLTDLKEDVLLDVLGLAHQYGFEELE 112

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 282 FLCHKAFFCGRSDYFKALLEDHFSESEElQTQPTIPvvtlhnISEDIFIRVLYYIYSDDTELSPENA-----YDVLCVAD 356
Cdd:cd18302    18 FPCHKCVLVARLEYFHSMLSSSWIEASS-CSALTMP------IPSDILEIILDYLYTDEASAVKESQnveflCNVLVIAD 90

                          90
                  ....*....|....*....
gi 1985392714 357 MYLLPGLKRLCGRTLAQIL 375
Cdd:cd18302    91 QLLITRLKEICEVALVELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 234 CRLQEDLALLADCALpaelrvgfgelpfdstdnFSscpDVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEELQtq 313
Cdd:cd18279     3 CRLAEDLGNLWENSR------------------FT---DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR-- 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985392714 314 ptipvVTLHNISEDIFIRVLYYIYSDDTELSPENAYDVLCVADMYLLPGLKRLCGRTLAQILDEDN 379
Cdd:cd18279    60 -----VEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqtqptiPVVTLHNISEDIFIRVLYYIYSDDTELSPEN-AYD 350
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-------KEVELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                          90
                  ....*....|....*..
gi 1985392714 351 VLCVADMYLLPGLKRLC 367
Cdd:cd18300    84 LIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1985392714 106 QRLLeqGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMFEtkwkGKNMIALKHP-LINPAAFGSLLQYLYTGRL 178
Cdd:cd18289    23 QRLM--GLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS----GNSKSAFELPaTVPPACFQQILSFCYTGKL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985392714 108 LLEQGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWKGKNMIALKHPLINPAAFGSLLQYLYTGRLDIDVE 183
Cdd:cd18280     8 LLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPDDVE 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985392714 272 DVCFRVTDYNFLCHKAFFCGRSDYFKALLEDHFSESEElqtqptiPVVTLHNISEDIFIRVLYYIYSDDTELSPENAYDV 351
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDK-------NVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGL 86

                          90       100
                  ....*....|....*....|..
gi 1985392714 352 LCVADMYLLPGLKRLCGRTLAQ 373
Cdd:cd18298    87 LDLANSYCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1985392714 105 LQRLLEQGYQSDIVFIVHGKSFCAHRCILSARSVYFAEMFETKWK--GKNMIALKHplINPAAFGSLLQYLYTGR 177
Cdd:cd18279     9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEesKKNRVEIND--VDPEVFKEMMRFIYTGK 81