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Conserved domains on  [gi|1958759824|ref|XP_038960186|]
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G-protein-signaling modulator 1 isoform X6 [Rattus norvegicus]

Protein Classification

TPR and TPR_12 domain-containing protein( domain architecture ID 11421204)

protein containing domains TPR, TPR_12, and GoLoco

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-305 1.53e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.06  E-value: 1.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLrdqaveA 165
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEEALADYEQALELDPDD------A 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 166 QACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrngel 245
Cdd:COG0457    77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERALELDPDDAD----- 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 246 tARMNIAHLQLALGRLtsPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDREQN 305
Cdd:COG0457   146 -ALYNLGIALEKLGRY--EEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202
GoLoco pfam02188
GoLoco motif;
373-394 3.37e-07

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 46.26  E-value: 3.37e-07
                          10        20
                  ....*....|....*....|..
gi 1958759824 373 ECFFDLLSKFQSSRMDDQRCPL 394
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
426-446 2.22e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.22e-05
                          10        20
                  ....*....|....*....|.
gi 1958759824 426 EEFFDLIASSQSRRLDDQRAS 446
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
508-529 2.26e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|..
gi 1958759824 508 EDFFSLIQRVQAKRMDEQRVDL 529
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
474-494 2.42e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.42e-05
                          10        20
                  ....*....|....*....|.
gi 1958759824 474 DEFFNMLIKYQSSRIDDQRCP 494
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-305 1.53e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.06  E-value: 1.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLrdqaveA 165
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEEALADYEQALELDPDD------A 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 166 QACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrngel 245
Cdd:COG0457    77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERALELDPDDAD----- 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 246 tARMNIAHLQLALGRLtsPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDREQN 305
Cdd:COG0457   146 -ALYNLGIALEKLGRY--EEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202
TPR_12 pfam13424
Tetratricopeptide repeat;
86-157 1.62e-10

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 57.40  E-value: 1.62e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF--GDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 157
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
GoLoco pfam02188
GoLoco motif;
373-394 3.37e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 46.26  E-value: 3.37e-07
                          10        20
                  ....*....|....*....|..
gi 1958759824 373 ECFFDLLSKFQSSRMDDQRCPL 394
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
426-446 2.22e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.22e-05
                          10        20
                  ....*....|....*....|.
gi 1958759824 426 EEFFDLIASSQSRRLDDQRAS 446
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
508-529 2.26e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|..
gi 1958759824 508 EDFFSLIQRVQAKRMDEQRVDL 529
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
474-494 2.42e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.42e-05
                          10        20
                  ....*....|....*....|.
gi 1958759824 474 DEFFNMLIKYQSSRIDDQRCP 494
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 372-394 2.67e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|...
gi 1958759824  372 EECFFDLLSKFQSSRMDDQRCPL 394
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 473-495 2.78e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 2.78e-05
                           10        20
                   ....*....|....*....|...
gi 1958759824  473 GDEFFNMLIKYQSSRIDDQRCPP 495
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 425-447 5.30e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.18  E-value: 5.30e-05
                           10        20
                   ....*....|....*....|...
gi 1958759824  425 TEEFFDLIASSQSRRLDDQRASV 447
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 507-529 1.65e-04

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 38.64  E-value: 1.65e-04
                           10        20
                   ....*....|....*....|...
gi 1958759824  507 DEDFFSLIQRVQAKRMDEQRVDL 529
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 165-197 2.52e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.52e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958759824  165 AQACYSLGNTYTLLQDYERAAEYHLRHLVIAQE 197
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 86-310 2.56e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG--DKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLR---D 160
Cdd:NF040586  521 RAANNLAVSLRLLGDYREALELDREVLRRRRRVLgpDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVLggpD 600

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 161 QAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEG----RAC-WSLGNAYVSMGSPAQALTFAKKHLQIS 235
Cdd:NF040586  601 HPDTLRAAKSLAVALRRAGRLEEALELAED---TYERYRRRFGPDhpdtLAAaLSLANDLRALGDADEARELAREVLDRY 677

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 236 QEigdRNGE-----LTARMNIAHLQLALGRltsPAAAEkpdlagyeaqgarpkrtqRLSAETWDLLrlpldREQNGETHH 310
Cdd:NF040586  678 RR---VLGEdhpftLACRNNLAVLLRALGD---PEEAR------------------ELAEAALEGL-----RERLGPDHP 728
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-305 1.53e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.06  E-value: 1.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLrdqaveA 165
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEEALADYEQALELDPDD------A 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 166 QACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrngel 245
Cdd:COG0457    77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERALELDPDDAD----- 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 246 tARMNIAHLQLALGRLtsPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDREQN 305
Cdd:COG0457   146 -ALYNLGIALEKLGRY--EEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-303 2.27e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 78.90  E-value: 2.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLrdqaveA 165
Cdd:COG0457    43 EALYNLGLAYLRLGRYEEALADYEQALELDPDDAE------ALNNLGLALQALGRYEEALEDYDKALELDPDD------A 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 166 QACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQisQEIGDRNGEL 245
Cdd:COG0457   111 EALYNLGLALLELGRYDEAIEAYERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEA--AALAALLAAA 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759824 246 TARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDRE 303
Cdd:COG0457   183 LGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
TPR_12 pfam13424
Tetratricopeptide repeat;
86-157 1.62e-10

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 57.40  E-value: 1.62e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF--GDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 157
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 82-237 1.09e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.74  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  82 AAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdq 161
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPE------AFALLGEILLQLGDLDEAIVLLHEALELDPD---- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759824 162 avEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQE 237
Cdd:COG4783    71 --EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRPDEAIAALEKALELDPD 138
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 77-335 2.31e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.01  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  77 ELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSR 156
Cdd:COG3914    70 AAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAE------ALFNLGNLLLALGRLEEALAALRRALALNP 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 157 QLrdqaveAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQ 236
Cdd:COG3914   144 DF------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAE------ALNNLGNALQDLGRLEEAIAAYRRALELDP 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 237 EigdrngELTARMNIAHLQLALGrltspaaaEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDREQNGETHHT-GDWR 315
Cdd:COG3914   212 D------NADAHSNLLFALRQAC--------DWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAELLALARAwAQLV 277

                         250       260
                  ....*....|....*....|
gi 1958759824 316 GPSRDSLPLPMRSRKYQEGP 335
Cdd:COG3914   278 AAAAAPELPPPPNPRDPDRK 297
COG3899 COG3899
Predicted ATPase [General function prediction only];
77-303 3.58e-08

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 56.41  E-value: 3.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824   77 ELGDRAAQGRAYGNLGntHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSR 156
Cdd:COG3899    784 RHGNPPASARAYANLG--LLLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGL 861

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  157 QLRDQAVEAQACYSLGNTyTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQ 236
Cdd:COG3899    862 ETGDAALALLALAAAAAA-AAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAA 940

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759824  237 EIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDRE 303
Cdd:COG3899    941 AAAALAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAA 1007
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 73-290 7.36e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 7.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  73 SLVKELGDRAaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEfgdkaaERRAYSNLGNAHIFLGRFDVAAEHYKKTL 152
Cdd:COG2956    67 KLLERDPDRA---EALLELAQDYLKAGLLDRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 153 QLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELAdrvgegRACWSLGNAYVSMGSPAQALTFAKKHL 232
Cdd:COG2956   138 KLGPE------NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA------RALLLLAELYLEQGDYEEAIAALERAL 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759824 233 QISQEigdrngELTARMNIAHLQLALGRLTS------PAAAEKPDLAGYEAQGARPKRTQRLSA 290
Cdd:COG2956   206 EQDPD------YLPALPRLAELYEKLGDPEEalellrKALELDPSDDLLLALADLLERKEGLEA 263
TPR_12 pfam13424
Tetratricopeptide repeat;
126-197 3.04e-07

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 48.15  E-value: 3.04e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759824 126 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLR--DQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQE 197
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
GoLoco pfam02188
GoLoco motif;
373-394 3.37e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 46.26  E-value: 3.37e-07
                          10        20
                  ....*....|....*....|..
gi 1958759824 373 ECFFDLLSKFQSSRMDDQRCPL 394
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
COG3899 COG3899
Predicted ATPase [General function prediction only];
69-354 4.65e-07

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 52.94  E-value: 4.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824   69 ERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAI-------AKEFGDKAAERRAYSNLGnaHIFLGRF 141
Cdd:COG3899    729 ERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAAralaalaALRHGNPPASARAYANLG--LLLLGDY 806

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  142 DVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSP 221
Cdd:COG3899    807 EEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAAL 886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  222 AQALTFAKKHLQISQEIGDRNGELTARmniAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLD 301
Cdd:COG3899    887 AAAAAAAARLLAAAAAALAAAAAAAAL---AAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAA 963

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958759824  302 REQNGETHHTGDWRGPSRDSLPLPMRSRKYQEGPDAIERRPREGSHSPLDSAD 354
Cdd:COG3899    964 AAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALA 1016
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 78-195 1.30e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.42  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  78 LGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 157
Cdd:COG5010    47 RDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE------LYYNLALLYSRSGDKDEAKEYYEKALALSPD 120

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958759824 158 lrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIA 195
Cdd:COG5010   121 ------NPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 122-261 1.71e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 122 AAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYhlrhlvIAQELADR 201
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPD------NPEAFALLGEILLQLGDLDEAIVL------LHEALELD 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 202 VGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrngeltARMNIAHLQLALGRL 261
Cdd:COG4783    69 PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRP 122
COG3899 COG3899
Predicted ATPase [General function prediction only];
99-297 2.74e-06

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 50.63  E-value: 2.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824   99 GNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQL-------SRQLRDQAVEAQACYSL 171
Cdd:COG3899    719 GAYAEALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAAralaalaALRHGNPPASARAYANL 798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  172 GntYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDRNGELTARMNI 251
Cdd:COG3899    799 G--LLLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAA 876

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958759824  252 AHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLR 297
Cdd:COG3899    877 AAAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLA 922
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 74-233 2.97e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.96  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  74 LVKELGDRAaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFgdkaaeRRAYSNLGNAHIFLGRFDVAAEHYKKTLQ 153
Cdd:COG2956   136 LLKLGPENA---HAYCELAELYLEQGDYDEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 154 LSRQLrdqaveAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVgegracwSLGNAYVSMGSPAQALTFAKKHLQ 233
Cdd:COG2956   207 QDPDY------LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQLR 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
164-261 5.47e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 5.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 164 EAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrng 243
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAE--- 77

                          90
                  ....*....|....*...
gi 1958759824 244 eltARMNIAHLQLALGRL 261
Cdd:COG0457    78 ---ALNNLGLALQALGRY 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 127-269 1.51e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 127 AYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ----------------LRDQAVEA------------QACYSLGNTYTLL 178
Cdd:COG2956    44 AHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeallelaqdylkagLLDRAEELleklleldpddaEALRLLAEIYEQE 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 179 QDYERAAEYHLRHLVIAQELADRVGEgracwsLGNAYVSMGSPAQALTFAKKHLQISQEigdrngELTARMNIAHLQLAL 258
Cdd:COG2956   124 GDWEKAIEVLERLLKLGPENAHAYCE------LAELYLEQGDYDEAIEALEKALKLDPD------CARALLLLAELYLEQ 191

                         170
                  ....*....|.
gi 1958759824 259 GRltsPAAAEK 269
Cdd:COG2956   192 GD---YEEAIA 199
GoLoco pfam02188
GoLoco motif;
426-446 2.22e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.22e-05
                          10        20
                  ....*....|....*....|.
gi 1958759824 426 EEFFDLIASSQSRRLDDQRAS 446
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
508-529 2.26e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|..
gi 1958759824 508 EDFFSLIQRVQAKRMDEQRVDL 529
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
474-494 2.42e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.25  E-value: 2.42e-05
                          10        20
                  ....*....|....*....|.
gi 1958759824 474 DEFFNMLIKYQSSRIDDQRCP 494
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 372-394 2.67e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|...
gi 1958759824  372 EECFFDLLSKFQSSRMDDQRCPL 394
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 473-495 2.78e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 2.78e-05
                           10        20
                   ....*....|....*....|...
gi 1958759824  473 GDEFFNMLIKYQSSRIDDQRCPP 495
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR_12 pfam13424
Tetratricopeptide repeat;
169-237 3.31e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.31e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958759824 169 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 237
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
86-207 3.50e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEAttfhkerlaiAKEFgDKAAERR-----AYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRD 160
Cdd:COG4785   108 EAYNNRGLAYLLLGDYDAA----------LEDF-DRALELDpdyayAYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958759824 161 QAVEAQACYslgntytLLQDYERAAEYHLRHLVIAQELADRVGEGRA 207
Cdd:COG4785   177 RALWLYLAE-------RKLDPEKALALLLEDWATAYLLQGDTEEARE 216
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 425-447 5.30e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.18  E-value: 5.30e-05
                           10        20
                   ....*....|....*....|...
gi 1958759824  425 TEEFFDLIASSQSRRLDDQRASV 447
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
134-237 6.51e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.08  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 134 AHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHlRHLVIAQELADrvgegrACWSLGN 213
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPD------NADALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAE------ALLNLAE 67

                          90       100
                  ....*....|....*....|....
gi 1958759824 214 AYVSMGSPAQALTFAKKHLQISQE 237
Cdd:COG3063    68 LLLELGDYDEALAYLERALELDPS 91
TPR_7 pfam13176
Tetratricopeptide repeat;
167-201 7.05e-05

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 40.22  E-value: 7.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958759824 167 ACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADR 201
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALALAKDPYDR 35
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 126-235 1.05e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 126 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQEladrvgEG 205
Cdd:COG4235    18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPD------NADALLDLAEALLAAGDTEEAEELLERALALDPD------NP 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958759824 206 RACWSLGNAYVSMGSPAQALTFAKKHLQIS 235
Cdd:COG4235    86 EALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
95-187 1.11e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  95 HYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDvAAEHYKKTLQLSRQlrdqavEAQACYSLGNT 174
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNAD------ALNNLGLLLLEQGRYD-EAIALEKALKLDPN------NAEALLNLAEL 68

                          90
                  ....*....|...
gi 1958759824 175 YTLLQDYERAAEY 187
Cdd:COG3063    69 LLELGDYDEALAY 81
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 131-260 1.12e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 131 LGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELAdrvgegRACWS 210
Cdd:COG2956    14 KGLNYLLNGQPDKAIDLLEEALELDPE------TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRA------EALLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958759824 211 LGNAYVSMGSPAQALTFAKKHLQISQEigdrngELTARMNIAHLQLALGR 260
Cdd:COG2956    82 LAQDYLKAGLLDRAEELLEKLLELDPD------DAEALRLLAEIYEQEGD 125
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
85-160 1.19e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 1.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759824  85 GRAYGNLGNTHYLLGNFTEATTFHKerlAIAKEFGDKaaerRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRD 160
Cdd:COG3063    26 ADALNNLGLLLLEQGRYDEAIALEK---ALKLDPNNA----EALLNLAELLLELGDYDEALAYLERALELDPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 74-187 1.43e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  74 LVKELGDRAAQ----GRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYK 149
Cdd:COG4235     2 AIARLRQALAAnpndAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNAD------ALLDLAEALLAAGDTEEAEELLE 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958759824 150 KTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEY 187
Cdd:COG4235    76 RALALDPD------NPEALYLLGLAAFQQGDYAEAIAA 107
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 507-529 1.65e-04

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 38.64  E-value: 1.65e-04
                           10        20
                   ....*....|....*....|...
gi 1958759824  507 DEDFFSLIQRVQAKRMDEQRVDL 529
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
COG3899 COG3899
Predicted ATPase [General function prediction only];
119-316 2.29e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 44.08  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  119 GDKAAERRAYsnlgnahiflgrfDVAAEHYKKTLQLSRQLRDQAVE-------AQACYSLGNTYTLLQDYERAAEYHLRH 191
Cdd:COG3899    712 ARRALARGAY-------------AEALRYLERALELLPPDPEEEYRlalllelAEALYLAGRFEEAEALLERALAARALA 778

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  192 LVIAQELADRVGEGRACWSLGNAYvsMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPD 271
Cdd:COG3899    779 ALAALRHGNPPASARAYANLGLLL--LGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREA 856

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1958759824  272 LAGYEAQGARPKRTQRLSAETWDLLRLPLDREQNGETHHTGDWRG 316
Cdd:COG3899    857 LEAGLETGDAALALLALAAAAAAAAAAAALAAAAAAAARLLAAAA 901
TPR_1 pfam00515
Tetratricopeptide repeat;
126-154 2.94e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*....
gi 1958759824 126 RAYSNLGNAHIFLGRFDVAAEHYKKTLQL 154
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALEL 30
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 134-230 3.01e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.36  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 134 AHIFLGRFDVAAEHYKktlQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEGRACWSLGN 213
Cdd:COG1729     2 ALLKAGDYDEAIAAFK---AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEK---LLKRYPDSPKAPDALLKLGL 75

                          90
                  ....*....|....*..
gi 1958759824 214 AYVSMGSPAQALTFAKK 230
Cdd:COG1729    76 SYLELGDYDKARATLEE 92
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 73-153 4.06e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  73 SLVKELGDRAAQGRAYGNLGNTHYLLGNFTEA-TTFhkerLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKT 151
Cdd:COG1729    18 AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAaEAF----EKLLKRYPDSPKAPDALLKLGLSYLELGDYDKARATLEEL 93


                  ..
gi 1958759824 152 LQ 153
Cdd:COG1729    94 IK 95
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 74-235 7.47e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  74 LVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQ 153
Cdd:COG5010     3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 154 LSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRhlviAQELADrvGEGRACWSLGNAYVSMGSPAQALTFAKKHLQ 233
Cdd:COG5010    83 LDPN------NPELYYNLALLYSRSGDKDEAKEYYEK----ALALSP--DNPNAYSNLAALLLSLGQDDEAKAALQRALG 150


                  ..
gi 1958759824 234 IS 235
Cdd:COG5010   151 TS 152
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 99-261 8.27e-04

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 41.91  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  99 GNFTEATTFHKERLAIAKEfgDKAAER-RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTl 177
Cdd:pfam17874  15 GDAERALELAEQALALLPE--DDLLARgLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWALLQQGEILR- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 178 LQDYERAAEYHLRHlviAQELADRVGE------GRACWSLGNAYVSMGSPAQALTFAKKHLQISQEiGDRNGELTARMNI 251
Cdd:pfam17874  92 AQGRLHQALETYQQ---ALQLARDHGLqhlplhGFLLVGLADLLYEWNDLEEAEQHAQQGIQLGRQ-WEPDAAVDAYVLL 167

                         170
                  ....*....|
gi 1958759824 252 AHLQLALGRL 261
Cdd:pfam17874 168 ARIALAQGEL 177
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 95-187 1.34e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.82  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  95 HYLLGNFTEA-TTFHKerlaIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSrqlRDQAVEAQACYSLGN 173
Cdd:COG1729     3 LLKAGDYDEAiAAFKA----FLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRY---PDSPKAPDALLKLGL 75

                          90
                  ....*....|....
gi 1958759824 174 TYTLLQDYERAAEY 187
Cdd:COG1729    76 SYLELGDYDKARAT 89
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 126-157 1.78e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.96  E-value: 1.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1958759824 126 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 157
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
TPR_12 pfam13424
Tetratricopeptide repeat;
66-117 2.25e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.98  E-value: 2.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958759824  66 SMSERNLSLVKEL--GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKE 117
Cdd:pfam13424  24 ELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 165-197 2.52e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.52e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958759824  165 AQACYSLGNTYTLLQDYERAAEYHLRHLVIAQE 197
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 86-310 2.56e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824  86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG--DKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLR---D 160
Cdd:NF040586  521 RAANNLAVSLRLLGDYREALELDREVLRRRRRVLgpDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVLggpD 600

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 161 QAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEG----RAC-WSLGNAYVSMGSPAQALTFAKKHLQIS 235
Cdd:NF040586  601 HPDTLRAAKSLAVALRRAGRLEEALELAED---TYERYRRRFGPDhpdtLAAaLSLANDLRALGDADEARELAREVLDRY 677

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 236 QEigdRNGE-----LTARMNIAHLQLALGRltsPAAAEkpdlagyeaqgarpkrtqRLSAETWDLLrlpldREQNGETHH 310
Cdd:NF040586  678 RR---VLGEdhpftLACRNNLAVLLRALGD---PEEAR------------------ELAEAALEGL-----RERLGPDHP 728
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
111-225 3.93e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759824 111 RLAIAKEFGDKAAERRA--YSNLGNAHIFLGRFDVAAEHYKKTLQLsrqlrdQAVEAQACYSLGNTYTLLQDYERAaeyh 188
Cdd:COG4785    57 ALAAERIDRALALPDLAqlYYERGVAYDSLGDYDLAIADFDQALEL------DPDLAEAYNNRGLAYLLLGDYDAA---- 126

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958759824 189 LRHLVIAQELADRvgEGRACWSLGNAYVSMGSPAQAL 225
Cdd:COG4785   127 LEDFDRALELDPD--YAYAYLNRGIALYYLGRYELAI 161
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 86-118 4.87e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.73  E-value: 4.87e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958759824   86 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF 118
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 126-157 7.81e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.34  E-value: 7.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958759824  126 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 157
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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