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Conserved domains on  [gi|1958759757|ref|XP_038960159|]
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adenylate kinase isoenzyme 1 isoform X1 [Rattus norvegicus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 22-209 8.23e-129

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 360.29  E-value: 8.23e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD 101
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 102 SSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 181
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1958759757 182 KRGIVRKVNAEGSVDTVFSQVCTYLDSL 209
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 22-209 8.23e-129

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 360.29  E-value: 8.23e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD 101
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 102 SSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 181
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1958759757 182 KRGIVRKVNAEGSVDTVFSQVCTYLDSL 209
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 26-198 1.58e-75

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 225.58  E-value: 1.58e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSNG 105
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 106 FLIDGYPREVKQGEEFERKI---AQPTLLLYVDAGPETMTQRLLKRGET-------------------SGRVDDNEETIK 163
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958759757 164 KRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTV 198
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
29-183 1.49e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 215.25  E-value: 1.49e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  29 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAKVDSSNGFLI 108
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 109 DGYPREVKQGEEFERK---IAQPTLLLYVDAGPETMTQRLLKRGET---------------------------SGRVDDN 158
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 1958759757 159 EETIKKRLETYYKATEPVISFYDKR 183
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 25-206 1.22e-64

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 198.81  E-value: 1.22e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 104
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIAQP----TLLLYVDAGPETMTQRLLKR---------------------------GETSG 153
Cdd:COG0563    80 GFILDGFPRTVAQAEALDELLAELgiklDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958759757 154 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYL 206
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 25-209 1.71e-64

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 198.45  E-value: 1.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 104
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIAQPTL----LLYVDAGPETMTQRLLKR---------------------------GETSG 153
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759757 154 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDSL 209
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 22-209 8.23e-129

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 360.29  E-value: 8.23e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD 101
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 102 SSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 181
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1958759757 182 KRGIVRKVNAEGSVDTVFSQVCTYLDSL 209
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 26-198 1.58e-75

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 225.58  E-value: 1.58e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSNG 105
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 106 FLIDGYPREVKQGEEFERKI---AQPTLLLYVDAGPETMTQRLLKRGET-------------------SGRVDDNEETIK 163
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958759757 164 KRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTV 198
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
29-183 1.49e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 215.25  E-value: 1.49e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  29 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAKVDSSNGFLI 108
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 109 DGYPREVKQGEEFERK---IAQPTLLLYVDAGPETMTQRLLKRGET---------------------------SGRVDDN 158
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 1958759757 159 EETIKKRLETYYKATEPVISFYDKR 183
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 26-202 2.17e-70

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 212.23  E-value: 2.17e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVS-SGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKvDSSN 104
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQED-GSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKI---AQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 181
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMdnkVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 1958759757 182 KRGIVRKVNAEGSVDTVFSQV 202
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 25-206 1.22e-64

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 198.81  E-value: 1.22e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 104
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIAQP----TLLLYVDAGPETMTQRLLKR---------------------------GETSG 153
Cdd:COG0563    80 GFILDGFPRTVAQAEALDELLAELgiklDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958759757 154 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYL 206
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 25-209 1.71e-64

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 198.45  E-value: 1.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 104
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIAQPTL----LLYVDAGPETMTQRLLKR---------------------------GETSG 153
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759757 154 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDSL 209
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 25-207 9.44e-56

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 175.89  E-value: 9.44e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDSSN 104
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIA-QPTLLLYVDAGPETMTQRLLKRG--ETSGRV-------------------------D 156
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEePIDAVIELDVPDEELVERLSGRRicPSCGRVyhlkfnppkvpgcddctgellvqreD 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958759757 157 DNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLD 207
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PLN02200 PLN02200
adenylate kinase family protein
 5-202 2.90e-54

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 173.15  E-value: 2.90e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757   5 LSSDPQEEGDRKTGDKLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVP 84
Cdd:PLN02200   24 FSTEIITLEERGSSSKEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  85 LETVLDMLRDAMlaKVDSSNGFLIDGYPREVKQGEEFERKI-AQPTLLLYVDAGPETMTQRLLKRGEtsGRVDDNEETIK 163
Cdd:PLN02200  104 SEVTVKLIQKEM--ESSDNNKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIK 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958759757 164 KRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQV 202
Cdd:PLN02200  180 KRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 23-207 3.25e-48

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 156.12  E-value: 3.25e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  23 KAKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlaKVDS 102
Cdd:PRK14531    2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 103 SNGFLIDGYPREVKQGEEFE---RKIAQP---TLLLYVDagPETMTQRLLKRgetsGRVDDNEETIKKRLETYYKATEPV 176
Cdd:PRK14531   79 SGGWLLDGFPRTVAQAEALEpllEELKQPieaVVLLELD--DAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPL 152

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958759757 177 ISFYDKRGIVRKVNAEGSVDTVFSQVCTYLD 207
Cdd:PRK14531  153 IDHYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 23-202 2.28e-46

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 151.48  E-value: 2.28e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  23 KAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDS 102
Cdd:PRK14527    5 KNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 103 SNgFLIDGYPREVKQGEEFERKIAQP----TLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIS 178
Cdd:PRK14527   84 VR-VIFDGFPRTLAQAEALDRLLEELgarlLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVD 162

                         170       180
                  ....*....|....*....|....
gi 1958759757 179 FYDKRGIVRKVNAEGSVDTVFSQV 202
Cdd:PRK14527  163 YYEARGHLKRVDGLGTPDEVYARI 186
PRK14532 PRK14532
adenylate kinase; Provisional
 26-198 5.21e-44

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 145.35  E-value: 5.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  26 IIFvvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSSNG 105
Cdd:PRK14532    4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEE-RLPEAEAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 106 FLIDGYPREVKQGEEFERKIA----QPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 181
Cdd:PRK14532   81 AIFDGFPRTVAQAEALDKMLAsrgqKIDVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPYYA 160

                         170
                  ....*....|....*..
gi 1958759757 182 KRGIVRKVNAEGSVDTV 198
Cdd:PRK14532  161 GQGKLTEVDGMGSIEAV 177
AAA_17 pfam13207
AAA domain;
30-163 3.11e-43

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 141.61  E-value: 3.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  30 VGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSsrGKMLSSIMEKGELVPLETVLDMLRDAMlAKVDSSNGFLID 109
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 110 GYPREVKQGEEFER------KIAQPTLLLYVDAGPETMTQRLLKRgETSGRVDDNEETIK 163
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14528 PRK14528
adenylate kinase; Provisional
 25-202 6.94e-42

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 139.76  E-value: 6.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSSN 104
Cdd:PRK14528    3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKD-RIREADCKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIAQPTL----LLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFY 180
Cdd:PRK14528   81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                         170       180
                  ....*....|....*....|..
gi 1958759757 181 DKRGIVRKVNAEGSVDTVFSQV 202
Cdd:PRK14528  161 AAQKKLSQVNGVGSLEEVTSLI 182
adk PRK02496
adenylate kinase; Provisional
 24-198 1.81e-41

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 138.73  E-value: 1.81e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  24 AKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSS 103
Cdd:PRK02496    2 TRLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQE-RLQQPDAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 104 NGFLIDGYPREVKQG---EEFERKIAQP-TLLLYVDAGPETMTQRLLKRgetsGRVDDNEETIKKRLETYYKATEPVISF 179
Cdd:PRK02496   80 NGWILDGFPRKVTQAaflDELLQEIGQSgERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                         170
                  ....*....|....*....
gi 1958759757 180 YDKRGIVRKVNAEGSVDTV 198
Cdd:PRK02496  156 YRDRQKLLTIDGNQSVEAV 174
PRK14530 PRK14530
adenylate kinase; Provisional
 27-208 2.43e-36

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 126.44  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRA---------EVSSGSSRgkmlsSIMEKGELVPLETVLDMLRDAMl 97
Cdd:PRK14530    6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVPDAVVNEIVEEAL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  98 akvDSSNGFLIDGYPREVKQGEEFErKIAQPTLLLYVDAGPETMTQRLLKR---------------------------GE 150
Cdd:PRK14530   80 ---SDADGFVLDGYPRNLEQAEYLE-SITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdecgGE 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759757 151 TSGRVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDS 208
Cdd:PRK14530  156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PLN02842 PLN02842
nucleotide kinase
 29-207 2.49e-35

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 129.98  E-value: 2.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  29 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDSSNGFLI 108
Cdd:PLN02842    2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 109 DGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKR-------------------GETSGRV----DDNEETIKKR 165
Cdd:PLN02842   82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppesEEIKARLitrpDDTEEKVKAR 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958759757 166 LETYYKATEPVISFYDKrgIVRKVNAEGSVDTVFSQVCTYLD 207
Cdd:PLN02842  162 LQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLLS 201
PRK13808 PRK13808
adenylate kinase; Provisional
 27-183 9.54e-32

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 117.68  E-value: 9.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSSNGF 106
Cdd:PRK13808    3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 107 LIDGYPREVKQGEEFERKIAQPTLL------LYVDAGP-----ETMTQRLLKRGETSgRVDDNEETIKKRLETYYKATEP 175
Cdd:PRK13808   82 ILDGFPRTVPQAEALDALLKDKQLKldavveLRVNEGAllarvETRVAEMRARGEEV-RADDTPEVLAKRLASYRAQTEP 160


                  ....*....
gi 1958759757 176 VISFY-DKR 183
Cdd:PRK13808  161 LVHYYsEKR 169
PLN02674 PLN02674
adenylate kinase
 22-202 1.67e-29

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 109.59  E-value: 1.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAKVD 101
Cdd:PLN02674   29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 102 SSNGFLIDGYPREVKQGEEFERKIAQ------PTLLLYVDAG--PETMTQRLLKrgETSGRV------------------ 155
Cdd:PLN02674  108 CQKGFILDGFPRTVVQAQKLDEMLAKqgakidKVLNFAIDDAilEERITGRWIH--PSSGRTyhtkfappkvpgvddvtg 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958759757 156 -------DDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQV 202
Cdd:PLN02674  186 epliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEV 239
PLN02459 PLN02459
probable adenylate kinase
 31-184 1.06e-26

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 102.62  E-value: 1.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  31 GGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDS-SNGFLID 109
Cdd:PLN02459   36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgESGFILD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 110 GYPREVKQGEEFERkIAQPTLLLYVDAGPETMTQRLLKR---GETSG--------------------------------- 153
Cdd:PLN02459  116 GFPRTVRQAEILEG-VTDIDLVVNLKLREEVLVEKCLGRricSECGKnfnvadidlkgedgrpgivmppllpppecaskl 194

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958759757 154 --RVDDNEETIKKRLETYYKATEPVISFYDKRG 184
Cdd:PLN02459  195 itRADDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PRK14526 PRK14526
adenylate kinase; Provisional
 25-198 8.20e-25

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 96.46  E-value: 8.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAkVDSSN 104
Cdd:PRK14526    2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINT-IKNND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 105 GFLIDGYPREVKQGEEFERKIAQPTLLLYVdAGPETMTQRLLKR---------------------------GETSGRVDD 157
Cdd:PRK14526   80 NFILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958759757 158 NEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTV 198
Cdd:PRK14526  159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 20-185 5.72e-23

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 92.17  E-value: 5.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  20 KLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAK 99
Cdd:PTZ00088    2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI-AK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 100 V--DSSNGFLIDGYPREVKQGEEFErKIAQPTLLLYVDAGPETMTQRLLKR----------------------------G 149
Cdd:PTZ00088   81 VtdDCFKGFILDGFPRNLKQCKELG-KITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958759757 150 ETSG---------RVDDNEETIKKRLETYYKATEPVISFYDKRGI 185
Cdd:PTZ00088  160 DCEGckgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 27-198 4.52e-17

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 76.30  E-value: 4.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlaKVDSSNGF 106
Cdd:PRK14529    3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 107 LIDGYPREVKQGEEFERKIAQPTLLL-YV--------DAGPETMTQRLLKR------------------------GETSG 153
Cdd:PRK14529   81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillpreVAKNRIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958759757 154 RVDD-NEETIKKRLETYYKATEPVIS---FY---DKRGIVR--KVNAEGSVDTV 198
Cdd:PRK14529  161 RADDqDEEAINKRHDIYYDTETGTLAaayFFkdlAAKGSTKyiELDGEGSIDEI 214
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 25-208 1.16e-08

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 53.04  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVVGGPGSGKGTQCEKIVQ---KYGYTHLSTGDLlraevsSGSSRGKMLSSIMEKGELVPLETVLDML-----RDAM 96
Cdd:cd01672     1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLlfaadRAQH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  97 LAKV-----------------DSS---NGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVD 156
Cdd:cd01672    75 VEEVikpalargkivlsdrfvDSSlayQGAGRGLGEALIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958759757 157 DNEETIKKRLETYYKatepVISFYDKRGIVrkVNAEGSVDTVFSQVCTYLDS 208
Cdd:cd01672   155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAILE 200
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 27-169 1.68e-07

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 48.85  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLssiMEKGELVPlETVLDMLRDAMLAKVDssngF 106
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYY---TDATDRTY-ERLHELARIALRAGRP----V 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759757 107 LIDG---YPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSG-RVDDNEETIKKRLETY 169
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARF 140
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
26-169 2.41e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 48.76  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTgDLLRAEVssgssRGKMLSSIMEKGELVPL--ETVLDMLRDAMLAKVDSs 103
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEATARtyARLLALARELLAAGRSV- 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958759757 104 ngfLID-GYPREvKQGEEFeRKIAQ----PTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETY 169
Cdd:COG0645    74 ---ILDaTFLRR-AQREAF-RALAEeagaPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE 139
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
25-165 7.36e-06

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 44.55  E-value: 7.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  25 KIIFVVGGPGSGKGtQCEKIVQKYGYTHLSTGDLLRAEVSSG------SSRGKMLSSIMEKgelvpletvLDMLRDAMLA 98
Cdd:PRK01184    2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEVKKRgleptdENIGKVAIDLRKE---------LGMDAVAKRT 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958759757  99 ----KVDSSNGFLIDGYpREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRgetsGRVDDNE--ETIKKR 165
Cdd:PRK01184   72 vpkiREKGDEVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDDPKswEELEER 139
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 26-69 1.12e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 43.63  E-value: 1.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958759757  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSR 69
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASE 44
PRK04182 PRK04182
cytidylate kinase; Provisional
 26-206 2.74e-04

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 40.17  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR--AEvssgsSRGkMlsSIMEKGELVPLETVLDMLRDAMLAKVDSS 103
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRelAK-----ERG-M--SLEEFNKYAEEDPEIDKEIDRRQLEIAEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757 104 NGFLIdgyprevkqgeeFERKIA------QPTLLLYVDAGPETMTQRLLKRGETSgrVDDN-EETI------KKRLETYY 170
Cdd:PRK04182   74 EDNVV------------LEGRLAgwmakdYADLKIWLKAPLEVRAERIAEREGIS--VEEAlEETIereeseAKRYKEYY 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1958759757 171 KatepvI-----SFYDkrgIV---RKVNAEGSVDTVFSQVCTYL 206
Cdd:PRK04182  140 G-----IdiddlSIYD---LVintSRWDPEGVFDIILTAIDKLL 175
AAA_18 pfam13238
AAA domain;
27-160 3.31e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 36.25  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759757  27 IFVVGGPGSGKGTQCEKIVQKYGY----THLSTGDLLRAEVSSGSSRGKmlssIMEKGELVPLETVLDMLRDAMLAKVDS 102
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFgdnvRDLALENGLVLGDDPETRESK----RLDEDKLDRLLDLLEENAALEEGGNLI 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759757 103 SNGFLIDGYPREVKQGEEFerkiaqptlllYVDAGPETMTQRLLKRGETSGRVDDNEE 160
Cdd:pfam13238  77 IDGHLAELEPERAKDLVGI-----------VLRASPEELLERLEKRGYEEAKIKENEE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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