Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) ...
145-443
1.64e-168
Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2
The actual alignment was detected with superfamily member TIGR02410:
Pssm-ID: 444731 [Multi-domain] Cd Length: 362 Bit Score: 477.73 E-value: 1.64e-168
trimethyllysine dioxygenase; Members of this family with known function act as trimethyllysine ...
145-443
1.64e-168
trimethyllysine dioxygenase; Members of this family with known function act as trimethyllysine dioxygenase, an enzyme in the pathway for carnitine biosynthesis from lysine. This enzyme is homologous to gamma-butyrobetaine,2-oxoglutarate dioxygenase, which catalyzes the last step in carnitine biosynthesis. Members of this family appear to be eukaryotic only.
Pssm-ID: 274119 [Multi-domain] Cd Length: 362 Bit Score: 477.73 E-value: 1.64e-168
Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) ...
166-432
6.30e-95
Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2
Pssm-ID: 238154 Cd Length: 262 Bit Score: 286.60 E-value: 6.30e-95
Taurine catabolism dioxygenase TauD, TfdA family; This family consists of taurine catabolism ...
211-418
7.74e-35
Taurine catabolism dioxygenase TauD, TfdA family; This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli is a alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyzes the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase. TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.
Pssm-ID: 367137 [Multi-domain] Cd Length: 264 Bit Score: 130.26 E-value: 7.74e-35
trimethyllysine dioxygenase; Members of this family with known function act as trimethyllysine ...
145-443
1.64e-168
trimethyllysine dioxygenase; Members of this family with known function act as trimethyllysine dioxygenase, an enzyme in the pathway for carnitine biosynthesis from lysine. This enzyme is homologous to gamma-butyrobetaine,2-oxoglutarate dioxygenase, which catalyzes the last step in carnitine biosynthesis. Members of this family appear to be eukaryotic only.
Pssm-ID: 274119 [Multi-domain] Cd Length: 362 Bit Score: 477.73 E-value: 1.64e-168
Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) ...
166-432
6.30e-95
Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2
Pssm-ID: 238154 Cd Length: 262 Bit Score: 286.60 E-value: 6.30e-95
gamma-butyrobetaine hydroxylase; Members of this protein family are gamma-butyrobetaine ...
145-441
6.57e-64
gamma-butyrobetaine hydroxylase; Members of this protein family are gamma-butyrobetaine hydroxylase, both bacterial and eukarytotic. This enzyme catalyzes the last step in the conversion of lysine to carnitine. Carnitine can serve as a compatible solvent in bacteria and also participates in fatty acid metabolism.
Pssm-ID: 274118 [Multi-domain] Cd Length: 366 Bit Score: 210.40 E-value: 6.57e-64
Taurine catabolism dioxygenase TauD, TfdA family; This family consists of taurine catabolism ...
211-418
7.74e-35
Taurine catabolism dioxygenase TauD, TfdA family; This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli is a alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyzes the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase. TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.
Pssm-ID: 367137 [Multi-domain] Cd Length: 264 Bit Score: 130.26 E-value: 7.74e-35
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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