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Conserved domains on  [gi|1958794332|ref|XP_038936628|]
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hsp90 co-chaperone Cdc37 isoform X1 [Rattus norvegicus]

Protein Classification

CDC37_N and CDC37_M domain-containing protein( domain architecture ID 10660770)

protein containing domains CDC37_N, CDC37_M, and CDC37_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 183-325 1.13e-61

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


:

Pssm-ID: 215010  Cd Length: 155  Bit Score: 196.83  E-value: 1.13e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  183 PEKAEEDSEEAREQKHKTFVEKYEKQIKHFGML--HRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVA 260
Cdd:smart01070   7 KNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIpaGDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALMEQVA 86

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794332  261 HQTMVMQFILELAKSLKVDPRACFRQFFTKIKT----ADQQYMEGFKYELEAFKERVRGRAKLRIEKAM 325
Cdd:smart01070  87 HQAILMQYILELAKSLKVDPRNCVRLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAEEAM 155
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 1-127 1.44e-45

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


:

Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 154.88  E-value: 1.44e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332    1 MVDYSVWDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQ-------------KEKEELDRGCREC----- 57
Cdd:smart01071   1 PIDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIKnlkyelimndhlnKRIDKLLKGLREEelspe 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794332   58 ----KRKVAECQRKL-KELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTlsKDGFSK 127
Cdd:smart01071  81 tptyNEMLAELQDQLkKELEEANGDSEGLLEELKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDK 153
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 337-427 1.39e-23

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


:

Pssm-ID: 215009  Cd Length: 93  Bit Score: 94.01  E-value: 1.39e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  337 LGPGGL--DPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLL 414
Cdd:smart01069   1 NLPGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWGVPNAIEDETEFKELQEQYEVE 80

                           90
                   ....*....|...
gi 1958794332  415 EAVPKAGNEKDIS 427
Cdd:smart01069  81 EEAEKEDEEEEDD 93
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 183-325 1.13e-61

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 196.83  E-value: 1.13e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  183 PEKAEEDSEEAREQKHKTFVEKYEKQIKHFGML--HRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVA 260
Cdd:smart01070   7 KNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIpaGDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALMEQVA 86

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794332  261 HQTMVMQFILELAKSLKVDPRACFRQFFTKIKT----ADQQYMEGFKYELEAFKERVRGRAKLRIEKAM 325
Cdd:smart01070  87 HQAILMQYILELAKSLKVDPRNCVRLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAEEAM 155
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 1-127 1.44e-45

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 154.88  E-value: 1.44e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332    1 MVDYSVWDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQ-------------KEKEELDRGCREC----- 57
Cdd:smart01071   1 PIDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIKnlkyelimndhlnKRIDKLLKGLREEelspe 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794332   58 ----KRKVAECQRKL-KELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTlsKDGFSK 127
Cdd:smart01071  81 tptyNEMLAELQDQLkKELEEANGDSEGLLEELKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDK 153
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 337-427 1.39e-23

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 94.01  E-value: 1.39e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  337 LGPGGL--DPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLL 414
Cdd:smart01069   1 NLPGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWGVPNAIEDETEFKELQEQYEVE 80

                           90
                   ....*....|...
gi 1958794332  415 EAVPKAGNEKDIS 427
Cdd:smart01069  81 EEAEKEDEEEEDD 93
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 212-325 3.00e-22

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 91.10  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332 212 FGMLHR--WDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAkslkvDPRACFRQFFT 289
Cdd:pfam08565   2 FAKIPSgdYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLD-----GRINGVKLFFK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958794332 290 KIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAM 325
Cdd:pfam08565  77 RITTKDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQA 112
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 340-392 1.95e-14

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 68.51  E-value: 1.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958794332 340 GGLDP-----VEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW 392
Cdd:pfam08564   6 GSEDPeeqkaVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGIL 63
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-68 3.18e-11

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 60.32  E-value: 3.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958794332   7 WDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQKEKEEldrgcRECKRKVAECQRKL 68
Cdd:pfam03234   2 WDALELSDDSDiEVHPNVDKRSFIRWKqrdiHEKREQRKAEIKTLKYE-----RIMNDGLLKRIDKL 63
PTZ00121 PTZ00121
MAEBL; Provisional
 37-123 1.72e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332   37 VERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAE------AQQLRKEERSWEQKLEDMRKKE 110
Cdd:PTZ00121  1646 KKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaeeakkAEELKKKEAEEKKKAEELKKAE 1725

                           90
                   ....*....|...
gi 1958794332  111 KNMPWNVDTLSKD 123
Cdd:PTZ00121  1726 EENKIKAEEAKKE 1738
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 34-136 2.17e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  34 QARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAegggQVELERLRAEAQQ----LRKEERSWEQKLEDMRKK 109
Cdd:COG4942   146 PARREQAEELRADLAELAALRAELEAERAELEALLAELEEE----RAALEALKAERQKllarLEKELAELAAELAELQQE 221

                          90       100
                  ....*....|....*....|....*..
gi 1958794332 110 EKNMPWNVDTLSKDGFSKARGHASATL 136
Cdd:COG4942   222 AEELEALIARLEAEAAAAAERTPAAGF 248
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 41-109 7.63e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 38.46  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  41 EQFQKEKEELDRGCRECKRKVAECQRKLK------------------ELEVAEGGGQV---ELERLRAEAQQLRKEERSW 99
Cdd:NF033838  128 EQFKKDTLEPGKKVAEATKKVEEAEKKAKdqkeedrrnyptntyktlELEIAESDVEVkkaELELVKEEAKEPRDEEKIK 207

                          90
                  ....*....|
gi 1958794332 100 EQKLEDMRKK 109
Cdd:NF033838  208 QAKAKVESKK 217
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 183-325 1.13e-61

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 196.83  E-value: 1.13e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  183 PEKAEEDSEEAREQKHKTFVEKYEKQIKHFGML--HRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVA 260
Cdd:smart01070   7 KNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIpaGDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALMEQVA 86

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794332  261 HQTMVMQFILELAKSLKVDPRACFRQFFTKIKT----ADQQYMEGFKYELEAFKERVRGRAKLRIEKAM 325
Cdd:smart01070  87 HQAILMQYILELAKSLKVDPRNCVRLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAEEAM 155
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 1-127 1.44e-45

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 154.88  E-value: 1.44e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332    1 MVDYSVWDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQ-------------KEKEELDRGCREC----- 57
Cdd:smart01071   1 PIDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIKnlkyelimndhlnKRIDKLLKGLREEelspe 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794332   58 ----KRKVAECQRKL-KELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTlsKDGFSK 127
Cdd:smart01071  81 tptyNEMLAELQDQLkKELEEANGDSEGLLEELKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDK 153
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 337-427 1.39e-23

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 94.01  E-value: 1.39e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  337 LGPGGL--DPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLL 414
Cdd:smart01069   1 NLPGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWGVPNAIEDETEFKELQEQYEVE 80

                           90
                   ....*....|...
gi 1958794332  415 EAVPKAGNEKDIS 427
Cdd:smart01069  81 EEAEKEDEEEEDD 93
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 212-325 3.00e-22

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 91.10  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332 212 FGMLHR--WDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAkslkvDPRACFRQFFT 289
Cdd:pfam08565   2 FAKIPSgdYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLD-----GRINGVKLFFK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958794332 290 KIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAM 325
Cdd:pfam08565  77 RITTKDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQA 112
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 340-392 1.95e-14

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 68.51  E-value: 1.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958794332 340 GGLDP-----VEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW 392
Cdd:pfam08564   6 GSEDPeeqkaVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGIL 63
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-68 3.18e-11

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 60.32  E-value: 3.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958794332   7 WDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQKEKEEldrgcRECKRKVAECQRKL 68
Cdd:pfam03234   2 WDALELSDDSDiEVHPNVDKRSFIRWKqrdiHEKREQRKAEIKTLKYE-----RIMNDGLLKRIDKL 63
PTZ00121 PTZ00121
MAEBL; Provisional
 37-123 1.72e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332   37 VERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAE------AQQLRKEERSWEQKLEDMRKKE 110
Cdd:PTZ00121  1646 KKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaeeakkAEELKKKEAEEKKKAEELKKAE 1725

                           90
                   ....*....|...
gi 1958794332  111 KNMPWNVDTLSKD 123
Cdd:PTZ00121  1726 EENKIKAEEAKKE 1738
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 34-136 2.17e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  34 QARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAegggQVELERLRAEAQQ----LRKEERSWEQKLEDMRKK 109
Cdd:COG4942   146 PARREQAEELRADLAELAALRAELEAERAELEALLAELEEE----RAALEALKAERQKllarLEKELAELAAELAELQQE 221

                          90       100
                  ....*....|....*....|....*..
gi 1958794332 110 EKNMPWNVDTLSKDGFSKARGHASATL 136
Cdd:COG4942   222 AEELEALIARLEAEAAAAAERTPAAGF 248
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
38-105 2.53e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 2.53e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958794332   38 ERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLED 105
Cdd:COG4913    338 DRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEE 405
PTZ00121 PTZ00121
MAEBL; Provisional
 30-126 6.17e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 6.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332   30 RWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQvELERLRAEAQQLRKEERSWEQKL--EDMR 107
Cdd:PTZ00121  1708 KKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKK-KIAHLKKEEEKKAEEIRKEKEAVieEELD 1786

                           90
                   ....*....|....*....
gi 1958794332  108 KKEKNMPWNVDTLSKDGFS 126
Cdd:PTZ00121  1787 EEDEKRRMEVDKKIKDIFD 1805
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
34-112 6.58e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.98  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  34 QARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAEAQ---------QLRKEERSWEQKLE 104
Cdd:COG4717    84 EEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAElaelperleELEERLEELRELEE 163


                  ....*...
gi 1958794332 105 DMRKKEKN 112
Cdd:COG4717   164 ELEELEAE 171
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 41-109 7.63e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 38.46  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  41 EQFQKEKEELDRGCRECKRKVAECQRKLK------------------ELEVAEGGGQV---ELERLRAEAQQLRKEERSW 99
Cdd:NF033838  128 EQFKKDTLEPGKKVAEATKKVEEAEKKAKdqkeedrrnyptntyktlELEIAESDVEVkkaELELVKEEAKEPRDEEKIK 207

                          90
                  ....*....|
gi 1958794332 100 EQKLEDMRKK 109
Cdd:NF033838  208 QAKAKVESKK 217
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 23-112 9.75e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 38.14  E-value: 9.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  23 IDTASlfrwrhqARVeRMEQFQKEkEELDrgcreckrkvaECQRKLKELEVaegggqvELERLRAE--------AQQLRK 94
Cdd:COG0542   395 IDEAA-------ARV-RMEIDSKP-EELD-----------ELERRLEQLEI-------EKEALKKEqdeasferLAELRD 447

                          90
                  ....*....|....*...
gi 1958794332  95 EERSWEQKLEDMRKKEKN 112
Cdd:COG0542   448 ELAELEEELEALKARWEA 465
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 38-124 9.80e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 37.95  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794332  38 ERMEQfQKEKEELDRGcRECKR-KVAECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEdmrkKEKNMPWN 116
Cdd:pfam07888 337 ERMER-EKLEVELGRE-KDCNRvQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLE----TVADAKWS 410


                  ....*...
gi 1958794332 117 VDTLSKDG 124
Cdd:pfam07888 411 EAALTSTE 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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