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Conserved domains on  [gi|1951390848|ref|XP_038549567|]
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ankyrin repeat and SOCS box protein 7 isoform X2 [Micropterus salmoides]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-256 1.13e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.13e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  22 LQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRAR 101
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 102 IARLMLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN 181
Cdd:COG0666   102 IVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390848 182 IDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTP 256
Cdd:COG0666   179 VNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 279-323 7.27e-24

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239696  Cd Length: 45  Bit Score: 91.83  E-value: 7.27e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1951390848 279 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHKFDN 323
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-256 1.13e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.13e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  22 LQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRAR 101
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 102 IARLMLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN 181
Cdd:COG0666   102 IVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390848 182 IDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTP 256
Cdd:COG0666   179 VNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 279-323 7.27e-24

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 91.83  E-value: 7.27e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1951390848 279 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHKFDN 323
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 27-247 1.05e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 94.67  E-value: 1.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  27 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKdFIGGFTALHYAAMHGRARIARLM 106
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVK-YPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 107 LES-EFRSDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 185
Cdd:PHA02875   88 LDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1951390848 186 NGF---LLRYAVIKGNHSYCRMFLQRGADTN-LGRleDGQTPLHLSALRDDVL-CAQMLYMYGADTN 247
Cdd:PHA02875  165 DCCgctPLIIAMAKGDIAICKMLLDSGANIDyFGK--NGCVAALCYAIENNKIdIVRLFIKRGADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
91-186 9.02e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 9.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  91 LHYAAMHGRARIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFrAEVDpLSDKGTTPLQLAIIRERSS 170
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1951390848 171 CVRILLDHSANIDIQN 186
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 280-318 1.50e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.55  E-value: 1.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951390848 280 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLK 318
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 282-320 4.03e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 4.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1951390848  282 RTLQDLCRIKIRHCIGlqslkFLEELPIAKVMKDYLKHK 320
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 55-228 1.96e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  55 TLLHFSAAKGKERCVRVFLE-HGADPTVKDFIGGfTALHYAAMHGRARIARLMLEsEFRSDIINAKSND---GWTPLHVA 130
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGE-TALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 131 AHYGRDSFVRLLLEFRAEV--------------DPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYA 193
Cdd:cd22192    97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHIL 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1951390848 194 VIKGNHSY-CRMF---LQRGADTNLGRLE-----DGQTPLHLSA 228
Cdd:cd22192   177 VLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpnnQGLTPFKLAA 220
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 122-150 3.21e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.21e-04
                           10        20
                   ....*....|....*....|....*....
gi 1951390848  122 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 150
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 19-113 3.06e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  19 HEELQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLH-------FSAAKGKERC-----VRVFLEHGADPTVKDFI- 85
Cdd:TIGR00870 174 HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmeneFKAEYEELSCqmynfALSLLDKLRDSKELEVIl 253

                          90       100       110
                  ....*....|....*....|....*....|
gi 1951390848  86 --GGFTALHYAAMHGRARIARLMLESEFRS 113
Cdd:TIGR00870 254 nhQGLTPLKLAAKEGRIVLFRLKLAIKYKQ 283
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-256 1.13e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.13e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  22 LQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRAR 101
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 102 IARLMLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN 181
Cdd:COG0666   102 IVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390848 182 IDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTP 256
Cdd:COG0666   179 VNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
26-186 5.87e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.44  E-value: 5.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  26 AAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARL 105
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 106 MLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 185
Cdd:COG0666   205 LLE---AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                  .
gi 1951390848 186 N 186
Cdd:COG0666   282 L 282
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 279-323 7.27e-24

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 91.83  E-value: 7.27e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1951390848 279 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHKFDN 323
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 27-247 1.05e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 94.67  E-value: 1.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  27 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKdFIGGFTALHYAAMHGRARIARLM 106
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVK-YPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 107 LES-EFRSDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 185
Cdd:PHA02875   88 LDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1951390848 186 NGF---LLRYAVIKGNHSYCRMFLQRGADTN-LGRleDGQTPLHLSALRDDVL-CAQMLYMYGADTN 247
Cdd:PHA02875  165 DCCgctPLIIAMAKGDIAICKMLLDSGANIDyFGK--NGCVAALCYAIENNKIdIVRLFIKRGADCN 229
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
82-256 2.82e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 2.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  82 KDFIGGFTALHYAAMHGRARIARLMLESEFRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQ 161
Cdd:COG0666    13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 162 LAIIRERSSCVRILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQM 238
Cdd:COG0666    93 AAARNGDLEIVKLLLEAGADVNARDKDgetPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIVKL 171

                         170
                  ....*....|....*...
gi 1951390848 239 LYMYGADTNTRNYEGQTP 256
Cdd:COG0666   172 LLEAGADVNARDNDGETP 189
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 69-261 1.72e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 91.48  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  69 VRVFLEHGADPTVKDFIGGFTALHYAAMHGRARIARLMLESEFRSDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFRAE 148
Cdd:PHA02878  150 TKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNN---SPLHHAVKHYNKPIVHILLENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 149 VDPLSDKGTTPLQLAIirersscvrilldhsanidiqnGFLLRYAVIKgnhsycrMFLQRGADTNLGRLEDGQTPLHLSA 228
Cdd:PHA02878  227 TDARDKCGNTPLHISV----------------------GYCKDYDILK-------LLLEHGVDVNAKSYILGLTALHSSI 277

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1951390848 229 LRDDVLcaQMLYMYGADTNTRNYEGQTPVAVSV 261
Cdd:PHA02878  278 KSERKL--KLLLEYGADINSLNSYKLTPLSSAV 308
Ank_2 pfam12796
Ankyrin repeats (3 copies);
91-186 9.02e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 9.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  91 LHYAAMHGRARIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFrAEVDpLSDKGTTPLQLAIIRERSS 170
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1951390848 171 CVRILLDHSANIDIQN 186
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-150 7.96e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 7.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  57 LHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLEsEFRSDIInaksNDGWTPLHVAAHYGRD 136
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE-HADVNLK----DNGRTALHYAARSGHL 74

                          90
                  ....*....|....
gi 1951390848 137 SFVRLLLEFRAEVD 150
Cdd:pfam12796  75 EIVKLLLEKGADIN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-194 2.59e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.93  E-value: 2.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  35 TVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLEsefRSD 114
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKHNFFDIIKLLLE---KGA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 115 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGFL-LRYA 193
Cdd:PHA02874  182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDIDGSTpLHHA 261


                  .
gi 1951390848 194 V 194
Cdd:PHA02874  262 I 262
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-117 1.32e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  27 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGAdptVKDFIGGFTALHYAAMHGRARIARLM 106
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 1951390848 107 LESEFRSDIIN 117
Cdd:pfam12796  81 LEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-183 1.65e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.68  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  32 DVCTVRRMLEQGYSPKIRDANGWTLLHFSA--AKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARiarlmles 109
Cdd:PHA03095  166 NVELLRLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATD-MLGNTPLHSMATGSSCK-------- 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 110 efRSDI---------INAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSA 180
Cdd:PHA03095  237 --RSLVlplliagisINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNP 314


                  ...
gi 1951390848 181 NID 183
Cdd:PHA03095  315 SAE 317
Ank_2 pfam12796
Ankyrin repeats (3 copies);
127-214 2.82e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 2.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 127 LHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDH-SANIDIQNGFLLRYAVIKGNHSYCRMF 205
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVNLKDNGRTALHYAARSGHLEIVKLL 80


                  ....*....
gi 1951390848 206 LQRGADTNL 214
Cdd:pfam12796  81 LEKGADINV 89
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 279-320 1.97e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 66.37  E-value: 1.97e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1951390848 279 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-257 2.26e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 2.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  32 DVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERC---VRVFLEHGADPTVKDfIGGFTALHYAAMHG-RARIARLML 107
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPE-RCGFTPLHLYLYNAtTLDVIKLLI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 108 ESEFRsdiINAKSNDGWTPLHV-----AAHYGrdsFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSS--CVRILLDHSA 180
Cdd:PHA03095  105 KAGAD---VNAKDKVGRTPLHVylsgfNINPK---VIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRLLIDAGA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 181 NI----DIQNGFLLRYAV-IKGNHSYCRMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCAQM--LYMYGADTNTRNYEG 253
Cdd:PHA03095  179 DVyavdDRFRSLLHHHLQsFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYG 257


                  ....
gi 1951390848 254 QTPV 257
Cdd:PHA03095  258 QTPL 261
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 280-320 7.57e-14

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.80  E-value: 7.57e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951390848 280 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 35-190 8.04e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.62  E-value: 8.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  35 TVRRMLEQGYSPKIRDANGWTLLHFSAAKGKE--RCVRVFLEHGADPTVKDFIGgFTALHYAAMHGRA--RIARLMLESe 110
Cdd:PHA03100   88 IVKLLLEYGANVNAPDNNGITPLLYAISKKSNsySIVEYLLDNGANVNIKNSDG-ENLLHLYLESNKIdlKILKLLIDK- 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 111 fRSDI---------------INAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRIL 175
Cdd:PHA03100  166 -GVDInaknrvnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244

                         170
                  ....*....|....*
gi 1951390848 176 LDHSANIDIQNGFLL 190
Cdd:PHA03100  245 LNNGPSIKTIIETLL 259
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 36-248 9.76e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.23  E-value: 9.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  36 VRRMLEQGYSPKIRDANGWTLLHF-SAAKGKERCVR----VFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESE 110
Cdd:PHA03100   51 VKILLDNGADINSSTKNNSTPLHYlSNIKYNLTDVKeivkLLLEYGANVNAPD-NNGITPLLYAISKKSNSYSIVEYLLD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 111 FRSDiINAKSNDGWTPLHVAAHYGRDSF--VRLLLEFRAEVDplsdkgttplqlAIIRersscVRILLDHSANIDIQN-- 186
Cdd:PHA03100  130 NGAN-VNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDIN------------AKNR-----VNYLLSYGVPINIKDvy 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1951390848 187 GFL-LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNT 248
Cdd:PHA03100  192 GFTpLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 11-186 1.34e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.15  E-value: 1.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  11 VKRRNPELHEELQIqaAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTA 90
Cdd:PHA02874  117 VNIKDAELKTFLHY--AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SP 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  91 LHYAAMHGRARIARLMLESefrSDIINAKSNDGWTPLHVAAHYGRdSFVRLLLEfRAEVDPLSDKGTTPLQLAIireRSS 170
Cdd:PHA02874  194 LHNAAEYGDYACIKLLIDH---GNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLHHAI---NPP 265

                         170       180
                  ....*....|....*....|
gi 1951390848 171 C----VRILLDHSANIDIQN 186
Cdd:PHA02874  266 CdidiIDILLYHKADISIKD 285
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-277 1.64e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.25  E-value: 1.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  21 ELQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHF-SAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHG- 98
Cdd:PHA02876  241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHaSQAPSLSRLVPKLLERGADVNAKN-IKGETPLYLMAKNGy 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  99 -RARIARLMLesefRSDIINAKSNDGWTPLHVAAHYGRDS-FVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILL 176
Cdd:PHA02876  320 dTENIRTLIM----LGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 177 DHSANIDIQN---GFLLRYAVIKGN-HSYCRMFLQRGADTNlGRLEDGQTPLHLSALRD---DVLcaQMLYMYGADTNTR 249
Cdd:PHA02876  396 DYGADIEALSqkiGTALHFALCGTNpYMSVKTLIDRGANVN-SKNKDLSTPLHYACKKNcklDVI--EMLLDNGADVNAI 472

                         250       260
                  ....*....|....*....|....*...
gi 1951390848 250 NYEGQTPVAVSVSMSGISRPCLDFLQEV 277
Cdd:PHA02876  473 NIQNQYPLLIALEYHGIVNILLHYGAEL 500
PHA03095 PHA03095
ankyrin-like protein; Provisional
 13-233 5.02e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.28  E-value: 5.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  13 RRNPelheeLQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLH-FSAAKGKE-RCVRVFLEHGADPTVKDFIgGFTA 90
Cdd:PHA03095  117 GRTP-----LHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvLLKSRNANvELLRLLIDAGADVYAVDDR-FRSL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  91 LHYAAMHGRARiARLMLESEFRSDIINAKSNDGWTPLHVAAHYG--RDSFVRLLLEFRAEVDPLSDKGTTPLQlaiirer 168
Cdd:PHA03095  191 LHHHLQSFKPR-ARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLH------- 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1951390848 169 sscvrilldhsanidiqngfllrYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDV 233
Cdd:PHA03095  263 -----------------------YAAVFNNPRACRRLIALGADINA-VSSDGNTPLSLMVRNNNG 303
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 55-321 7.67e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 7.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  55 TLLHFSAAKGKER-CVRVFLEHGADPTVKDFIGgFTALHYAAM------HGRaRIARLMLESEFRsdiINAKSNDGWTPL 127
Cdd:PHA03100   36 VLPLYLAKEARNIdVVKILLDNGADINSSTKNN-STPLHYLSNikynltDVK-EIVKLLLEYGAN---VNAPDNNGITPL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 128 HVAAHYGRDSF--VRLLLEFRAEVDPLSDKGTTPLQLAI--IRERSSCVRILLDHSANIDIQNgfllryaVIKgnhsycr 203
Cdd:PHA03100  111 LYAISKKSNSYsiVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKN-------RVN------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 204 MFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSVsmsgisRPC-LDFLQEVTKQPR 282
Cdd:PHA03100  177 YLLSYGVPINI-KDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI------LNNnKEIFKLLLNNGP 249

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1951390848 283 TLQDLCRikirhCIGLQSLKFLEELPIAKVMKDYLKHKF 321
Cdd:PHA03100  250 SIKTIIE-----TLLYFKDKDLNTITKIKMLKKSIMYMF 283
PHA03095 PHA03095
ankyrin-like protein; Provisional
 36-261 9.78e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 9.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  36 VRRMLEQGYSPKIRDANGWTLLHFSA-AKGKERCVRVFLEHGADPTVKDFIgGFTALH-YAA-MHGRARIARLMLesEFR 112
Cdd:PHA03095   66 VRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIKAGADVNAKDKV-GRTPLHvYLSgFNINPKVIRLLL--RKG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 113 SDiINAKSNDGWTPLHVAAHYGR--DSFVRLLLEFRAEVDPLSDKGTTPLQ--LAIIRERSSCVRILLDHSANIDIQNGF 188
Cdd:PHA03095  143 AD-VNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIRAGCDPAATDML 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1951390848 189 LLRYAVIKGNHSYCRM-----FLQRGADTNLgRLEDGQTPLHLSA-LRDDVLCAQMLYMyGADTNTRNYEGQTPVAVSV 261
Cdd:PHA03095  222 GNTPLHSMATGSSCKRslvlpLLIAGISINA-RNRYGQTPLHYAAvFNNPRACRRLIAL-GADINAVSSDGNTPLSLMV 298
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 26-186 2.88e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.59  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  26 AAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARL 105
Cdd:PLN03192  531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRD-ANGNTALWNAISAKHHKIFRI 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 106 MLESEFRSDiinakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 185
Cdd:PLN03192  610 LYHFASISD-----PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKA 684


                  .
gi 1951390848 186 N 186
Cdd:PLN03192  685 N 685
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 280-318 1.50e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.55  E-value: 1.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951390848 280 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLK 318
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
53-107 1.68e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 1.68e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1951390848  53 GWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLML 107
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 61-162 4.30e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.60  E-value: 4.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  61 AAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRARIARLMLesEFRSDiINAKSNDGWTPLHVAAHYGRDSFVR 140
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLL--EFGAD-PTLLDKDGKTPLELAEENGFREVVQ 165

                          90       100
                  ....*....|....*....|....*....
gi 1951390848 141 LLL-------EFRAEVDPLSDKGTTPLQL 162
Cdd:PTZ00322  166 LLSrhsqchfELGANAKPDSFTGKPPSLE 194
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 29-107 4.62e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.60  E-value: 4.62e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1951390848  29 AAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLML 107
Cdd:PTZ00322   91 ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK-TPLELAEENGFREVVQLLS 168
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 101-257 7.79e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.61  E-value: 7.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 101 RIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSA 180
Cdd:PHA02876  159 LIAEMLLEGGAD---VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 181 NI--------------DIQNGFLLRYAVIKGNH----------------SYCRM---FLQRGADTNLGRLEdGQTPLHLS 227
Cdd:PHA02876  236 NInkndlsllkairneDLETSLLLYDAGFSVNSiddckntplhhasqapSLSRLvpkLLERGADVNAKNIK-GETPLYLM 314

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1951390848 228 ALRD-DVLCAQMLYMYGADTNTRNYEGQTPV 257
Cdd:PHA02876  315 AKNGyDTENIRTLIMLGADVNAADRLYITPL 345
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 90-267 9.15e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 9.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  90 ALHYAAMHGRARIARLMLESEFRSdiiNAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERS 169
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINP---NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 170 SCVRILLDHSANID---IQNGFL-LRYAVIKGNHSYCRMFLQRGADTNLGRlEDGQTPLHLSALRDDVLCAQMLYMYGAD 245
Cdd:PHA02875   82 KAVEELLDLGKFADdvfYKDGMTpLHLATILKKLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKAC 160

                         170       180
                  ....*....|....*....|..
gi 1951390848 246 TNTRNYEGQTPVAVSVSMSGIS 267
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGDIA 182
Ank_4 pfam13637
Ankyrin repeats (many copies);
123-176 3.20e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 3.20e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390848 123 GWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILL 176
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 190-320 4.19e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 53.83  E-value: 4.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 190 LRYAVIKGNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSvsmsgiSRP 269
Cdd:PHA02884   74 LIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA------LMI 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1951390848 270 CLDFLQEVTKQpRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:PHA02884  148 CNNFLAFMICD-NEISNFYKHPKKILINFDILKILVSHFILQASNDRLNEK 197
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 92-264 1.09e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.33  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  92 HYAAMHGrARIARLMLESEFRSDIINAKSNdgwtpLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSC 171
Cdd:PLN03192  500 HHKELHD-LNVGDLLGDNGGEHDDPNMASN-----LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDC 573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 172 VRILLDHSANI---DIQNGFLLRYAVIKGNHSYCRMFLQrgadtnLGRLEDGQTP---LHLSALRDDVLCAQMLYMYGAD 245
Cdd:PLN03192  574 VLVLLKHACNVhirDANGNTALWNAISAKHHKIFRILYH------FASISDPHAAgdlLCTAAKRNDLTAMKELLKQGLN 647

                         170
                  ....*....|....*....
gi 1951390848 246 TNTRNYEGQTpvAVSVSMS 264
Cdd:PLN03192  648 VDSEDHQGAT--ALQVAMA 664
Ank_4 pfam13637
Ankyrin repeats (many copies);
89-143 1.74e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 1.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1951390848  89 TALHYAAMHGRARIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLL 143
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 282-320 4.03e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 4.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1951390848  282 RTLQDLCRIKIRHCIGlqslkFLEELPIAKVMKDYLKHK 320
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
26-123 9.07e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 9.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  26 AAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARL 105
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL-TALLLAAAAGAALIVKL 270

                          90
                  ....*....|....*...
gi 1951390848 106 MLESEFRSDIINAKSNDG 123
Cdd:COG0666   271 LLLALLLLAAALLDLLTL 288
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 89-261 9.24e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 9.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  89 TALHYAAMHGRARIARLMLESEFRSDIINAKSNDgwtPLHVAAHYGRDSFVRLLLefraevdplsDKGTTPLQLAIIRER 168
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPH---PLLTAIKIGAHDIIKLLI----------DNGVDTSILPIPCIE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 169 SSCVRILLDHSANIDIQNGFL---LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGAD 245
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELktfLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         170
                  ....*....|....*.
gi 1951390848 246 TNTRNYEGQTPVAVSV 261
Cdd:PHA02874  183 ANVKDNNGESPLHNAA 198
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 279-318 1.02e-06

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 44.51  E-value: 1.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951390848 279 KQPRTLQDLCRIKIRHCIGLQSlkfLEELPIAKVMKDYLK 318
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRRDL---IDQLPLPRRLKDYLK 37
Ank_5 pfam13857
Ankyrin repeats (many copies);
110-163 1.14e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390848 110 EFRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLA 163
Cdd:pfam13857   3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 156-272 1.66e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 156 GTTPLQLAIIRERSSCVRILLDHSANIDIQNGFL---LRYAVIKGNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDD 232
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIeseLHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKK 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1951390848 233 VLCAQMLYMYGADTNTRNYEGQTPVAVSVSMSGIS--------RPCLD 272
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKgiellidhKACLD 162
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 55-228 1.96e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  55 TLLHFSAAKGKERCVRVFLE-HGADPTVKDFIGGfTALHYAAMHGRARIARLMLEsEFRSDIINAKSND---GWTPLHVA 130
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGE-TALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 131 AHYGRDSFVRLLLEFRAEV--------------DPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYA 193
Cdd:cd22192    97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHIL 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1951390848 194 VIKGNHSY-CRMF---LQRGADTNLGRLE-----DGQTPLHLSA 228
Cdd:cd22192   177 VLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpnnQGLTPFKLAA 220
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 112-261 6.82e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 112 RSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIqngfllr 191
Cdd:PHA02874   24 KGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI------- 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 192 YAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSV 261
Cdd:PHA02874   97 LPIPCIEKDMIKTILDCGIDVNI-KDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 281-320 9.35e-06

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 42.53  E-value: 9.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1951390848 281 PRTLQDLCRIKIRHCIGLQSLK---FLEELPIAKVMKDYLKHK 320
Cdd:cd03730     3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 280-317 1.26e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 41.52  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1951390848 280 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYL 317
Cdd:cd03718     2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYL 39
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 281-320 2.06e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.39  E-value: 2.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951390848 281 PRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 203-261 2.20e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 2.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1951390848 203 RMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSV 261
Cdd:PTZ00322   99 RILLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAE 156
Ank_5 pfam13857
Ankyrin repeats (many copies);
73-130 2.48e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 2.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390848  73 LEHGADPTVKDFIGGFTALHYAAMHGRARIARLMLesEFRSDiINAKSNDGWTPLHVA 130
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVD-LNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 36-127 3.34e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.43  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  36 VRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESEFRSDI 115
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACD-KQHKTPLYYLSGTDDEVIERINLLVQYGAKI 133

                          90
                  ....*....|..
gi 1951390848 116 INAKSNDGWTPL 127
Cdd:PHA02946  134 NNSVDEEGCGPL 145
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 279-320 3.61e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.36  E-value: 3.61e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1951390848  279 KQPRTLQDLCRIKIRHCIGLQSLKfleELPIAKVMKDYLKHK 320
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIK---TLPLPPKLKDYLSYY 43
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 280-320 3.65e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 40.32  E-value: 3.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951390848 280 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:cd03743     2 EPLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 122-150 5.00e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 5.00e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1951390848 122 DGWTPLHVAA-HYGRDSFVRLLLEFRAEVD 150
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
24-73 6.84e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 6.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1951390848  24 IQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFL 73
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 27-133 7.71e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.21  E-value: 7.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  27 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGFTALHYAAMHGRARIARLM 106
Cdd:PHA02875  142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLF 221

                          90       100
                  ....*....|....*....|....*..
gi 1951390848 107 LESEFRSDIINAKSNDGWTPLHVAAHY 133
Cdd:PHA02875  222 IKRGADCNIMFMIEGEECTILDMICNM 248
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 106-257 8.44e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 8.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 106 MLESEFRSDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAnidiq 185
Cdd:PHA02874  110 ILDCGIDVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA----- 181

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1951390848 186 ngfllrYAVIKGNHsycrmflqrgadtnlgrledGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPV 257
Cdd:PHA02874  182 ------YANVKDNN--------------------GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 281-320 8.85e-05

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 39.82  E-value: 8.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1951390848 281 PRTLQDLCRIKIRHCIGLQSLK---FLEELPIAKVMKDYLKHK 320
Cdd:cd03731     3 PRPLKHLCRLKIRKLMGLQKLQqpsSMKKLPLPPALKRYILYK 45
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 122-150 1.10e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 1.10e-04
                          10        20
                  ....*....|....*....|....*....
gi 1951390848 122 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 150
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
156-206 1.88e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390848 156 GTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFL 206
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNgetALHFAASNGNVEVLKLLL 54
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 281-320 2.20e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 38.32  E-value: 2.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951390848 281 PRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 52-83 2.23e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 2.23e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1951390848  52 NGWTLLHFSAAK-GKERCVRVFLEHGADPTVKD 83
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
48-94 2.29e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 2.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1951390848  48 IRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYA 94
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL-TALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
190-274 2.72e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 190 LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYgADTNTRNYeGQTPVAVSVSMSgiSRP 269
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSG--HLE 75


                  ....*
gi 1951390848 270 CLDFL 274
Cdd:pfam12796  76 IVKLL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 116-289 3.04e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 116 INAKSNDGWTPLHVAAHYGRD---SFVRLLLEFRAEVDPLSDKGTTPLQLaiirersscvriLLDHSANIDIqngfllry 192
Cdd:PHA03095   40 VNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHL------------YLYNATTLDV-------- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 193 avikgnhsyCRMFLQRGADTNLgRLEDGQTPLH--LSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSVSMSGISRPC 270
Cdd:PHA03095  100 ---------IKLLIKAGADVNA-KDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVEL 169

                         170
                  ....*....|....*....
gi 1951390848 271 LDFLQEVTKQPRTLQDLCR 289
Cdd:PHA03095  170 LRLLIDAGADVYAVDDRFR 188
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 122-150 3.21e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.21e-04
                           10        20
                   ....*....|....*....|....*....
gi 1951390848  122 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 150
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 280-317 3.24e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 37.81  E-value: 3.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1951390848 280 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYL 317
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYL 39
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 155-186 8.15e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 8.15e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1951390848 155 KGTTPLQLAIIRERS-SCVRILLDHSANIDIQN 186
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARD 33
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 279-320 1.08e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 36.30  E-value: 1.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1951390848 279 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 320
Cdd:cd03729     1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
189-239 1.24e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1951390848 189 LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQML 239
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLL 53
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 125-185 1.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.97  E-value: 1.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1951390848 125 TPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGT-TPLQLAIIRERSSCVRILLDHSANIDIQ 185
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQ 133
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 172-262 1.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 172 VRILLDHSANIDIQN----GFLLRYAVIKGNHSYCRMFLQRGADTNLGRLEDgQTPLH--LSALRDDVLcaQMLYMYGAD 245
Cdd:PHA02878  150 TKLLLSYGADINMKDrhkgNTALHYATENKDQRLTELLLSYGANVNIPDKTN-NSPLHhaVKHYNKPIV--HILLENGAS 226

                          90
                  ....*....|....*..
gi 1951390848 246 TNTRNYEGQTPVAVSVS 262
Cdd:PHA02878  227 TDARDKCGNTPLHISVG 243
Ank_5 pfam13857
Ankyrin repeats (many copies);
208-257 1.53e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1951390848 208 RGADTNLGRLEdGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPV 257
Cdd:pfam13857   5 GPIDLNRLDGE-GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 219-250 2.00e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 2.00e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1951390848 219 DGQTPLHLSALR-DDVLCAQMLYMYGADTNTRN 250
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 57-134 2.02e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  57 LHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLM----LESEFRSDII---NAKSNDGWTPLHV 129
Cdd:cd22192   140 LSFAACVGNEEIVRLLIEHGADIRAQDSLGN-TVLHILVLQPNKTFACQMydliLSYDKEDDLQpldLVPNNQGLTPFKL 218


                  ....*
gi 1951390848 130 AAHYG 134
Cdd:cd22192   219 AAKEG 223
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 19-113 3.06e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  19 HEELQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLH-------FSAAKGKERC-----VRVFLEHGADPTVKDFI- 85
Cdd:TIGR00870 174 HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmeneFKAEYEELSCqmynfALSLLDKLRDSKELEVIl 253

                          90       100       110
                  ....*....|....*....|....*....|
gi 1951390848  86 --GGFTALHYAAMHGRARIARLMLESEFRS 113
Cdd:TIGR00870 254 nhQGLTPLKLAAKEGRIVLFRLKLAIKYKQ 283
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 52-81 3.82e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.82e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1951390848   52 NGWTLLHFSAAKGKERCVRVFLEHGADPTV 81
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 281-319 4.03e-03

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 34.70  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951390848 281 PRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKH 319
Cdd:cd03720     3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
SOCS_SOCS1 cd03735
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the ...
 282-318 5.01e-03

SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. SOCS1 has a dual function as a direct potent JAK kinase inhibitor and as a component of an E3 ubiquitin-ligase complex recruiting substrates to the protein degradation machinery.


Pssm-ID: 239704  Cd Length: 43  Bit Score: 34.51  E-value: 5.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1951390848 282 RTLQDLCRIKIRHCIGLQSLkflEELPIAKVMKDYLK 318
Cdd:cd03735     4 RPLQELCRKSIVATFGRENL---ARIPLNPVLKDYLK 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 87-109 5.13e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 5.13e-03
                           10        20
                   ....*....|....*....|...
gi 1951390848   87 GFTALHYAAMHGRARIARLMLES 109
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDK 24
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 126-264 5.52e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.32  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 126 PLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLA-----------IIRERSSC-----VRILLD--HSANIDIQNG 187
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIIckepnklgmkeMIRSINKCsvfytLVAIKDafNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848 188 FLLRYavIKGNHS------------------YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTR 249
Cdd:PHA02878  120 ILTNR--YKNIQTidlvyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIP 197

                         170
                  ....*....|....*
gi 1951390848 250 NYEGQTPVAVSVSMS 264
Cdd:PHA02878  198 DKTNNSPLHHAVKHY 212
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 4-165 5.90e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848   4 RSSSLQLVKRRNPELHEEL--QIQAAVAAGDVCTVRRMLEqgyspkIRDANGWTLLHFSAAKGKercvRVFLEHGADPTV 81
Cdd:TIGR00870  53 RSALFVAAIENENLELTELllNLSCRGAVGDTLLHAISLE------YVDAVEAILLHLLAAFRK----SGPLELANDQYT 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390848  82 KDFIGGFTALHYAAMHGRARIARLMLESEFRsdiINAKSN--------------DGWTPLHVAAHYGRDSFVRLLLEFRA 147
Cdd:TIGR00870 123 SEFTPGITALHLAAHRQNYEIVKLLLERGAS---VPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPA 199

                         170
                  ....*....|....*...
gi 1951390848 148 EVDPLSDKGTTPLQLAII 165
Cdd:TIGR00870 200 DILTADSLGNTLLHLLVM 217
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 155-184 6.82e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 6.82e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1951390848  155 KGTTPLQLAIIRERSSCVRILLDHSANIDI 184
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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