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Conserved domains on  [gi|1951390844|ref|XP_038549565|]
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ankyrin repeat and SOCS box protein 7 isoform X1 [Micropterus salmoides]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-263 1.60e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  29 LQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRAR 108
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 109 IARLMLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN 188
Cdd:COG0666   102 IVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390844 189 IDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTP 263
Cdd:COG0666   179 VNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 286-330 1.54e-23

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239696  Cd Length: 45  Bit Score: 91.06  E-value: 1.54e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1951390844 286 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHKFDN 330
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-263 1.60e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  29 LQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRAR 108
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 109 IARLMLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN 188
Cdd:COG0666   102 IVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390844 189 IDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTP 263
Cdd:COG0666   179 VNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 286-330 1.54e-23

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 91.06  E-value: 1.54e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1951390844 286 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHKFDN 330
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-254 1.19e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 94.67  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  34 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKdFIGGFTALHYAAMHGRARIARLM 113
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVK-YPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 114 LES-EFRSDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:PHA02875   88 LDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1951390844 193 NGF---LLRYAVIKGNHSYCRMFLQRGADTN-LGRleDGQTPLHLSALRDDVL-CAQMLYMYGADTN 254
Cdd:PHA02875  165 DCCgctPLIIAMAKGDIAICKMLLDSGANIDyFGK--NGCVAALCYAIENNKIdIVRLFIKRGADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
98-193 1.79e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  98 LHYAAMHGRARIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFrAEVDpLSDKGTTPLQLAIIRERSS 177
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1951390844 178 CVRILLDHSANIDIQN 193
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 287-325 2.22e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.17  E-value: 2.22e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951390844 287 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLK 325
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 289-327 5.70e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1951390844  289 RTLQDLCRIKIRHCIGlqslkFLEELPIAKVMKDYLKHK 327
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 62-235 2.21e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  62 TLLHFSAAKGKERCVRVFLE-HGADPTVKDFIGGfTALHYAAMHGRARIARLMLEsEFRSDIINAKSND---GWTPLHVA 137
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGE-TALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 138 AHYGRDSFVRLLLEFRAEV--------------DPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYA 200
Cdd:cd22192    97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHIL 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1951390844 201 VIKGNHSY-CRMF---LQRGADTNLGRLE-----DGQTPLHLSA 235
Cdd:cd22192   177 VLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpnnQGLTPFKLAA 220
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 129-157 4.58e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 4.58e-04
                           10        20
                   ....*....|....*....|....*....
gi 1951390844  129 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 157
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 26-120 3.29e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  26 HEELQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLH-------FSAAKGKERC-----VRVFLEHGADPTVKDFI- 92
Cdd:TIGR00870 174 HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmeneFKAEYEELSCqmynfALSLLDKLRDSKELEVIl 253

                          90       100       110
                  ....*....|....*....|....*....|
gi 1951390844  93 --GGFTALHYAAMHGRARIARLMLESEFRS 120
Cdd:TIGR00870 254 nhQGLTPLKLAAKEGRIVLFRLKLAIKYKQ 283
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-263 1.60e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  29 LQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRAR 108
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 109 IARLMLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN 188
Cdd:COG0666   102 IVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390844 189 IDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTP 263
Cdd:COG0666   179 VNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-193 7.95e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.05  E-value: 7.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  33 AAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARL 112
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 113 MLEsefRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:COG0666   205 LLE---AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                  .
gi 1951390844 193 N 193
Cdd:COG0666   282 L 282
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 286-330 1.54e-23

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 91.06  E-value: 1.54e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1951390844 286 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHKFDN 330
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-254 1.19e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 94.67  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  34 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKdFIGGFTALHYAAMHGRARIARLM 113
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVK-YPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 114 LES-EFRSDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:PHA02875   88 LDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1951390844 193 NGF---LLRYAVIKGNHSYCRMFLQRGADTN-LGRleDGQTPLHLSALRDDVL-CAQMLYMYGADTN 254
Cdd:PHA02875  165 DCCgctPLIIAMAKGDIAICKMLLDSGANIDyFGK--NGCVAALCYAIENNKIdIVRLFIKRGADCN 229
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-263 3.69e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.55  E-value: 3.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  89 KDFIGGFTALHYAAMHGRARIARLMLESEFRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQ 168
Cdd:COG0666    13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 169 LAIIRERSSCVRILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQM 245
Cdd:COG0666    93 AAARNGDLEIVKLLLEAGADVNARDKDgetPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIVKL 171

                         170
                  ....*....|....*...
gi 1951390844 246 LYMYGADTNTRNYEGQTP 263
Cdd:COG0666   172 LLEAGADVNARDNDGETP 189
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 76-268 2.87e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 91.09  E-value: 2.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  76 VRVFLEHGADPTVKDFIGGFTALHYAAMHGRARIARLMLESEFRSDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFRAE 155
Cdd:PHA02878  150 TKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNN---SPLHHAVKHYNKPIVHILLENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 156 VDPLSDKGTTPLQLAIirersscvrilldhsanidiqnGFLLRYAVIKgnhsycrMFLQRGADTNLGRLEDGQTPLHLSA 235
Cdd:PHA02878  227 TDARDKCGNTPLHISV----------------------GYCKDYDILK-------LLLEHGVDVNAKSYILGLTALHSSI 277

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1951390844 236 LRDDVLcaQMLYMYGADTNTRNYEGQTPVAVSV 268
Cdd:PHA02878  278 KSERKL--KLLLEYGADINSLNSYKLTPLSSAV 308
Ank_2 pfam12796
Ankyrin repeats (3 copies);
98-193 1.79e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  98 LHYAAMHGRARIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFrAEVDpLSDKGTTPLQLAIIRERSS 177
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1951390844 178 CVRILLDHSANIDIQN 193
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-157 1.60e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  64 LHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLEsEFRSDIInaksNDGWTPLHVAAHYGRD 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE-HADVNLK----DNGRTALHYAARSGHL 74

                          90
                  ....*....|....
gi 1951390844 144 SFVRLLLEFRAEVD 157
Cdd:pfam12796  75 EIVKLLLEKGADIN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 42-201 2.86e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.93  E-value: 2.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  42 TVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLEsefRSD 121
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKHNFFDIIKLLLE---KGA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 122 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGFL-LRYA 200
Cdd:PHA02874  182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDIDGSTpLHHA 261


                  .
gi 1951390844 201 V 201
Cdd:PHA02874  262 I 262
Ank_2 pfam12796
Ankyrin repeats (3 copies);
34-124 2.35e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 2.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  34 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGAdptVKDFIGGFTALHYAAMHGRARIARLM 113
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 1951390844 114 LESEFRSDIIN 124
Cdd:pfam12796  81 LEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-190 2.60e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 2.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  39 DVCTVRRMLEQGYSPKIRDANGWTLLHFSA--AKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARiarlmles 116
Cdd:PHA03095  166 NVELLRLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATD-MLGNTPLHSMATGSSCK-------- 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 117 efRSDI---------INAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSA 187
Cdd:PHA03095  237 --RSLVlplliagisINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNP 314


                  ...
gi 1951390844 188 NID 190
Cdd:PHA03095  315 SAE 317
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-221 4.62e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 4.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 134 LHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDH-SANIDIQNGFLLRYAVIKGNHSYCRMF 212
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVNLKDNGRTALHYAARSGHLEIVKLL 80


                  ....*....
gi 1951390844 213 LQRGADTNL 221
Cdd:pfam12796  81 LEKGADINV 89
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 286-327 3.17e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.98  E-value: 3.17e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1951390844 286 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-264 3.71e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.75  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  39 DVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERC---VRVFLEHGADPTVKDfIGGFTALHYAAMHG-RARIARLML 114
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPE-RCGFTPLHLYLYNAtTLDVIKLLI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 115 ESEFRsdiINAKSNDGWTPLHV-----AAHYGrdsFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSS--CVRILLDHSA 187
Cdd:PHA03095  105 KAGAD---VNAKDKVGRTPLHVylsgfNINPK---VIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRLLIDAGA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 188 NI----DIQNGFLLRYAV-IKGNHSYCRMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCAQM--LYMYGADTNTRNYEG 260
Cdd:PHA03095  179 DVyavdDRFRSLLHHHLQsFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYG 257


                  ....
gi 1951390844 261 QTPV 264
Cdd:PHA03095  258 QTPL 261
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-197 8.16e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.62  E-value: 8.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  10 LVKRMLNHHCRRNPE-------LHEELQIQAaVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKE--RCVRVFL 80
Cdd:PHA03100   50 VVKILLDNGADINSStknnstpLHYLSNIKY-NLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNsySIVEYLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  81 EHGADPTVKDFIGgFTALHYAAMHGRA--RIARLMLESefRSDI---------------INAKSNDGWTPLHVAAHYGRD 143
Cdd:PHA03100  129 DNGANVNIKNSDG-ENLLHLYLESNKIdlKILKLLIDK--GVDInaknrvnyllsygvpINIKDVYGFTPLHYAVYNNNP 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390844 144 SFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGFLL 197
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLL 259
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 287-327 1.14e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.41  E-value: 1.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951390844 287 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 5-284 1.60e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.25  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844   5 SSSLQLVKRMLNHHCRRNpelHEELQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHF-SAAKGKERCVRVFLEHG 83
Cdd:PHA02876  221 SKNIDTIKAIIDNRSNIN---KNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHaSQAPSLSRLVPKLLERG 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  84 ADPTVKDfIGGFTALHYAAMHG--RARIARLMLesefRSDIINAKSNDGWTPLHVAAHYGRDS-FVRLLLEFRAEVDPLS 160
Cdd:PHA02876  298 ADVNAKN-IKGETPLYLMAKNGydTENIRTLIM----LGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARD 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 161 DKGTTPLQLAIIRERSSCVRILLDHSANIDIQN---GFLLRYAVIKGN-HSYCRMFLQRGADTNlGRLEDGQTPLHLSAL 236
Cdd:PHA02876  373 YCDKTPIHYAAVRNNVVIINTLLDYGADIEALSqkiGTALHFALCGTNpYMSVKTLIDRGANVN-SKNKDLSTPLHYACK 451

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1951390844 237 RD---DVLcaQMLYMYGADTNTRNYEGQTPVAVSVSMSGISRPCLDFLQEV 284
Cdd:PHA02876  452 KNcklDVI--EMLLDNGADVNAINIQNQYPLLIALEYHGIVNILLHYGAEL 500
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-193 1.66e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  34 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLM 113
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACIKLL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 114 LESefrSDIINAKSNDGWTPLHVAAHYGRdSFVRLLLEfRAEVDPLSDKGTTPLQLAIireRSSC----VRILLDHSANI 189
Cdd:PHA02874  210 IDH---GNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLHHAI---NPPCdidiIDILLYHKADI 281


                  ....
gi 1951390844 190 DIQN 193
Cdd:PHA02874  282 SIKD 285
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-240 1.95e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.82  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  19 CRRNPelheeLQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLH-FSAAKGKE-RCVRVFLEHGADPTVKDFIgGFT 96
Cdd:PHA03095  116 VGRTP-----LHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvLLKSRNANvELLRLLIDAGADVYAVDDR-FRS 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  97 ALHYAAMHGRARiARLMLESEFRSDIINAKSNDGWTPLHVAAHYG--RDSFVRLLLEFRAEVDPLSDKGTTPLQlaiire 174
Cdd:PHA03095  190 LLHHHLQSFKPR-ARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLH------ 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1951390844 175 rsscvrilldhsanidiqngfllrYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDV 240
Cdd:PHA03095  263 ------------------------YAAVFNNPRACRRLIALGADINA-VSSDGNTPLSLMVRNNNG 303
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-193 3.51e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 70.28  E-value: 3.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844   2 TKRSSSLQLVKRMLNHHCR-----------RNPELHEELQIQA----AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHF 66
Cdd:PLN03192  485 TRQEDNVVILKNFLQHHKElhdlnvgdllgDNGGEHDDPNMASnlltVASTGNAALLEELLKAKLDPDIGDSKGRTPLHI 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  67 SAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESEFRSDiinakSNDGWTPLHVAAHYGRDSFV 146
Cdd:PLN03192  565 AASKGYEDCVLVLLKHACNVHIRD-ANGNTALWNAISAKHHKIFRILYHFASISD-----PHAAGDLLCTAAKRNDLTAM 638

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1951390844 147 RLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQN 193
Cdd:PLN03192  639 KELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 62-328 8.26e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 8.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  62 TLLHFSAAKGKER-CVRVFLEHGADPTVKDFIGgFTALHYAAM------HGRaRIARLMLESEFRsdiINAKSNDGWTPL 134
Cdd:PHA03100   36 VLPLYLAKEARNIdVVKILLDNGADINSSTKNN-STPLHYLSNikynltDVK-EIVKLLLEYGAN---VNAPDNNGITPL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 135 HVAAHYGRDSF--VRLLLEFRAEVDPLSDKGTTPLQLAI--IRERSSCVRILLDHSANIDIQNgfllryaVIKgnhsycr 210
Cdd:PHA03100  111 LYAISKKSNSYsiVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKN-------RVN------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 211 MFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSVsmsgisRPC-LDFLQEVTKQPR 289
Cdd:PHA03100  177 YLLSYGVPINI-KDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI------LNNnKEIFKLLLNNGP 249

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1951390844 290 TLQDLCRikirhCIGLQSLKFLEELPIAKVMKDYLKHKF 328
Cdd:PHA03100  250 SIKTIIE-----TLLYFKDKDLNTITKIKMLKKSIMYMF 283
PHA03095 PHA03095
ankyrin-like protein; Provisional
 43-268 1.55e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.13  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  43 VRRMLEQGYSPKIRDANGWTLLHFSA-AKGKERCVRVFLEHGADPTVKDFIgGFTALH-YAA-MHGRARIARLMLesEFR 119
Cdd:PHA03095   66 VRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIKAGADVNAKDKV-GRTPLHvYLSgFNINPKVIRLLL--RKG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 120 SDiINAKSNDGWTPLHVAAHYGR--DSFVRLLLEFRAEVDPLSDKGTTPLQ--LAIIRERSSCVRILLDHSANIDIQNGF 195
Cdd:PHA03095  143 AD-VNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIRAGCDPAATDML 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1951390844 196 LLRYAVIKGNHSYCRM-----FLQRGADTNLgRLEDGQTPLHLSA-LRDDVLCAQMLYMyGADTNTRNYEGQTPVAVSV 268
Cdd:PHA03095  222 GNTPLHSMATGSSCKRslvlpLLIAGISINA-RNRYGQTPLHYAAvFNNPRACRRLIAL-GADINAVSSDGNTPLSLMV 298
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 287-325 2.22e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.17  E-value: 2.22e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951390844 287 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLK 325
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
60-114 2.75e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 2.75e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1951390844  60 GWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLML 114
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 68-169 5.05e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.60  E-value: 5.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  68 AAKGKERCVRVFLEHGADPTVKDFiGGFTALHYAAMHGRARIARLMLesEFRSDiINAKSNDGWTPLHVAAHYGRDSFVR 147
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLL--EFGAD-PTLLDKDGKTPLELAEENGFREVVQ 165

                          90       100
                  ....*....|....*....|....*....
gi 1951390844 148 LLL-------EFRAEVDPLSDKGTTPLQL 169
Cdd:PTZ00322  166 LLSrhsqchfELGANAKPDSFTGKPPSLE 194
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 36-114 5.19e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 5.19e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1951390844  36 AAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLML 114
Cdd:PTZ00322   91 ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK-TPLELAEENGFREVVQLLS 168
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 108-264 8.98e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.61  E-value: 8.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 108 RIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSA 187
Cdd:PHA02876  159 LIAEMLLEGGAD---VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 188 NI--------------DIQNGFLLRYAVIKGNH----------------SYCRM---FLQRGADTNLGRLEdGQTPLHLS 234
Cdd:PHA02876  236 NInkndlsllkairneDLETSLLLYDAGFSVNSiddckntplhhasqapSLSRLvpkLLERGADVNAKNIK-GETPLYLM 314

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1951390844 235 ALRD-DVLCAQMLYMYGADTNTRNYEGQTPV 264
Cdd:PHA02876  315 AKNGyDTENIRTLIMLGADVNAADRLYITPL 345
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 97-274 9.67e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 9.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  97 ALHYAAMHGRARIARLMLESEFRSdiiNAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERS 176
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINP---NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 177 SCVRILLDHSANID---IQNGFL-LRYAVIKGNHSYCRMFLQRGADTNLGRlEDGQTPLHLSALRDDVLCAQMLYMYGAD 252
Cdd:PHA02875   82 KAVEELLDLGKFADdvfYKDGMTpLHLATILKKLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKAC 160

                         170       180
                  ....*....|....*....|..
gi 1951390844 253 TNTRNYEGQTPVAVSVSMSGIS 274
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGDIA 182
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 197-327 4.39e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 53.83  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 197 LRYAVIKGNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSvsmsgiSRP 276
Cdd:PHA02884   74 LIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA------LMI 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1951390844 277 CLDFLQEVTKQpRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:PHA02884  148 CNNFLAFMICD-NEISNFYKHPKKILINFDILKILVSHFILQASNDRLNEK 197
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-183 4.87e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 4.87e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390844 130 GWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILL 183
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 99-271 1.24e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.33  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  99 HYAAMHGrARIARLMLESEFRSDIINAKSNdgwtpLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSC 178
Cdd:PLN03192  500 HHKELHD-LNVGDLLGDNGGEHDDPNMASN-----LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDC 573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 179 VRILLDHSANI---DIQNGFLLRYAVIKGNHSYCRMFLQrgadtnLGRLEDGQTP---LHLSALRDDVLCAQMLYMYGAD 252
Cdd:PLN03192  574 VLVLLKHACNVhirDANGNTALWNAISAKHHKIFRILYH------FASISDPHAAgdlLCTAAKRNDLTAMKELLKQGLN 647

                         170
                  ....*....|....*....
gi 1951390844 253 TNTRNYEGQTpvAVSVSMS 271
Cdd:PLN03192  648 VDSEDHQGAT--ALQVAMA 664
Ank_4 pfam13637
Ankyrin repeats (many copies);
96-150 2.74e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 2.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1951390844  96 TALHYAAMHGRARIARLMLESEFRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLL 150
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 289-327 5.70e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1951390844  289 RTLQDLCRIKIRHCIGlqslkFLEELPIAKVMKDYLKHK 327
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 96-268 9.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 9.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  96 TALHYAAMHGRARIARLMLESEFRSDIINAKSNDgwtPLHVAAHYGRDSFVRLLLefraevdplsDKGTTPLQLAIIRER 175
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPH---PLLTAIKIGAHDIIKLLI----------DNGVDTSILPIPCIE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 176 SSCVRILLDHSANIDIQNGFL---LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGAD 252
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELktfLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         170
                  ....*....|....*.
gi 1951390844 253 TNTRNYEGQTPVAVSV 268
Cdd:PHA02874  183 ANVKDNNGESPLHNAA 198
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-130 9.89e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 9.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  33 AAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARL 112
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL-TALLLAAAAGAALIVKL 270

                          90
                  ....*....|....*...
gi 1951390844 113 MLESEFRSDIINAKSNDG 130
Cdd:COG0666   271 LLLALLLLAAALLDLLTL 288
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 286-325 1.22e-06

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 44.51  E-value: 1.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951390844 286 KQPRTLQDLCRIKIRHCIGLQSlkfLEELPIAKVMKDYLK 325
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRRDL---IDQLPLPRRLKDYLK 37
Ank_5 pfam13857
Ankyrin repeats (many copies);
117-170 1.64e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 1.64e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390844 117 EFRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLA 170
Cdd:pfam13857   3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 163-279 1.73e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 163 GTTPLQLAIIRERSSCVRILLDHSANIDIQNGFL---LRYAVIKGNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDD 239
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIeseLHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKK 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1951390844 240 VLCAQMLYMYGADTNTRNYEGQTPVAVSVSMSGIS--------RPCLD 279
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKgiellidhKACLD 162
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 62-235 2.21e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  62 TLLHFSAAKGKERCVRVFLE-HGADPTVKDFIGGfTALHYAAMHGRARIARLMLEsEFRSDIINAKSND---GWTPLHVA 137
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGE-TALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 138 AHYGRDSFVRLLLEFRAEV--------------DPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYA 200
Cdd:cd22192    97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHIL 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1951390844 201 VIKGNHSY-CRMF---LQRGADTNLGRLE-----DGQTPLHLSA 235
Cdd:cd22192   177 VLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpnnQGLTPFKLAA 220
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-268 7.13e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 7.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 119 RSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIqngfllr 198
Cdd:PHA02874   24 KGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI------- 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 199 YAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSV 268
Cdd:PHA02874   97 LPIPCIEKDMIKTILDCGIDVNI-KDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 288-327 1.35e-05

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 42.14  E-value: 1.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1951390844 288 PRTLQDLCRIKIRHCIGLQSLK---FLEELPIAKVMKDYLKHK 327
Cdd:cd03730     3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 287-324 1.42e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 41.52  E-value: 1.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1951390844 287 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYL 324
Cdd:cd03718     2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYL 39
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 288-327 2.42e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.00  E-value: 2.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951390844 288 PRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 210-268 2.49e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 2.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1951390844 210 RMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSV 268
Cdd:PTZ00322   99 RILLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAE 156
Ank_5 pfam13857
Ankyrin repeats (many copies);
80-137 3.51e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 3.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1951390844  80 LEHGADPTVKDFIGGFTALHYAAMHGRARIARLMLesEFRSDiINAKSNDGWTPLHVA 137
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVD-LNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 43-134 3.61e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.04  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  43 VRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESEFRSDI 122
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACD-KQHKTPLYYLSGTDDEVIERINLLVQYGAKI 133

                          90
                  ....*....|..
gi 1951390844 123 INAKSNDGWTPL 134
Cdd:PHA02946  134 NNSVDEEGCGPL 145
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 287-327 4.19e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 40.32  E-value: 4.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951390844 287 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:cd03743     2 EPLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 286-327 4.36e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.36  E-value: 4.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1951390844  286 KQPRTLQDLCRIKIRHCIGLQSLKfleELPIAKVMKDYLKHK 327
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIK---TLPLPPKLKDYLSYY 43
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 129-157 7.00e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 7.00e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1951390844 129 DGWTPLHVAA-HYGRDSFVRLLLEFRAEVD 157
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-140 8.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.21  E-value: 8.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  34 AVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGFTALHYAAMHGRARIARLM 113
Cdd:PHA02875  142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLF 221

                          90       100
                  ....*....|....*....|....*..
gi 1951390844 114 LESEFRSDIINAKSNDGWTPLHVAAHY 140
Cdd:PHA02875  222 IKRGADCNIMFMIEGEECTILDMICNM 248
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 113-264 8.79e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 8.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 113 MLESEFRSDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAnidiq 192
Cdd:PHA02874  110 ILDCGIDVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA----- 181

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1951390844 193 ngfllrYAVIKGNHsycrmflqrgadtnlgrledGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPV 264
Cdd:PHA02874  182 ------YANVKDNN--------------------GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
Ank_4 pfam13637
Ankyrin repeats (many copies);
31-80 9.30e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 9.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1951390844  31 IQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFL 80
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 288-327 9.79e-05

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 39.82  E-value: 9.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1951390844 288 PRTLQDLCRIKIRHCIGLQSLK---FLEELPIAKVMKDYLKHK 327
Cdd:cd03731     3 PRPLKHLCRLKIRKLMGLQKLQqpsSMKKLPLPPALKRYILYK 45
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 129-157 1.62e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 1.62e-04
                          10        20
                  ....*....|....*....|....*....
gi 1951390844 129 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 157
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 288-327 2.60e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 37.93  E-value: 2.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951390844 288 PRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
163-213 2.69e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 2.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951390844 163 GTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFL 213
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNgetALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-101 3.14e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 3.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1951390844  55 IRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYA 101
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL-TALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 59-90 3.24e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 3.24e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1951390844  59 NGWTLLHFSAAK-GKERCVRVFLEHGADPTVKD 90
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_2 pfam12796
Ankyrin repeats (3 copies);
197-281 4.01e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.94  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 197 LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYMYgADTNTRNYeGQTPVAVSVSMSgiSRP 276
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSG--HLE 75


                  ....*
gi 1951390844 277 CLDFL 281
Cdd:pfam12796  76 IVKLL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 123-296 4.12e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 123 INAKSNDGWTPLHVAAHYGRD---SFVRLLLEFRAEVDPLSDKGTTPLQLaiirersscvriLLDHSANIDIqngfllry 199
Cdd:PHA03095   40 VNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHL------------YLYNATTLDV-------- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 200 avikgnhsyCRMFLQRGADTNLgRLEDGQTPLH--LSALRDDVLCAQMLYMYGADTNTRNYEGQTPVAVSVSMSGISRPC 277
Cdd:PHA03095  100 ---------IKLLIKAGADVNA-KDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVEL 169

                         170
                  ....*....|....*....
gi 1951390844 278 LDFLQEVTKQPRTLQDLCR 296
Cdd:PHA03095  170 LRLLIDAGADVYAVDDRFR 188
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 287-324 4.54e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 37.42  E-value: 4.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1951390844 287 QPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYL 324
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYL 39
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 129-157 4.58e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 4.58e-04
                           10        20
                   ....*....|....*....|....*....
gi 1951390844  129 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 157
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 286-327 1.08e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 36.30  E-value: 1.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1951390844 286 KQPRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKHK 327
Cdd:cd03729     1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 162-193 1.13e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 1.13e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1951390844 162 KGTTPLQLAIIRERS-SCVRILLDHSANIDIQN 193
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARD 33
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 132-192 1.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.97  E-value: 1.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1951390844 132 TPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGT-TPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQ 133
Ank_4 pfam13637
Ankyrin repeats (many copies);
196-246 1.84e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1951390844 196 LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQML 246
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 179-269 1.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.86  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 179 VRILLDHSANIDIQN----GFLLRYAVIKGNHSYCRMFLQRGADTNLGRLEDgQTPLH--LSALRDDVLcaQMLYMYGAD 252
Cdd:PHA02878  150 TKLLLSYGADINMKDrhkgNTALHYATENKDQRLTELLLSYGANVNIPDKTN-NSPLHhaVKHYNKPIV--HILLENGAS 226

                          90
                  ....*....|....*..
gi 1951390844 253 TNTRNYEGQTPVAVSVS 269
Cdd:PHA02878  227 TDARDKCGNTPLHISVG 243
Ank_5 pfam13857
Ankyrin repeats (many copies);
215-264 2.10e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 2.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1951390844 215 RGADTNLGRLEdGQTPLHLSALRDDVLCAQMLYMYGADTNTRNYEGQTPV 264
Cdd:pfam13857   5 GPIDLNRLDGE-GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 64-141 2.23e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  64 LHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLM----LESEFRSDII---NAKSNDGWTPLHV 136
Cdd:cd22192   140 LSFAACVGNEEIVRLLIEHGADIRAQDSLGN-TVLHILVLQPNKTFACQMydliLSYDKEDDLQpldLVPNNQGLTPFKL 218


                  ....*
gi 1951390844 137 AAHYG 141
Cdd:cd22192   219 AAKEG 223
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 226-257 2.85e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.85e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1951390844 226 DGQTPLHLSALR-DDVLCAQMLYMYGADTNTRN 257
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 26-120 3.29e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844  26 HEELQIQAAVAAGDVCTVRRMLEQGYSPKIRDANGWTLLH-------FSAAKGKERC-----VRVFLEHGADPTVKDFI- 92
Cdd:TIGR00870 174 HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmeneFKAEYEELSCqmynfALSLLDKLRDSKELEVIl 253

                          90       100       110
                  ....*....|....*....|....*....|
gi 1951390844  93 --GGFTALHYAAMHGRARIARLMLESEFRS 120
Cdd:TIGR00870 254 nhQGLTPLKLAAKEGRIVLFRLKLAIKYKQ 283
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 288-326 4.78e-03

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 34.32  E-value: 4.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951390844 288 PRTLQDLCRIKIRHCIGLQSLKFLEELPIAKVMKDYLKH 326
Cdd:cd03720     3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
SOCS_SOCS1 cd03735
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the ...
 289-325 5.02e-03

SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. SOCS1 has a dual function as a direct potent JAK kinase inhibitor and as a component of an E3 ubiquitin-ligase complex recruiting substrates to the protein degradation machinery.


Pssm-ID: 239704  Cd Length: 43  Bit Score: 34.51  E-value: 5.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1951390844 289 RTLQDLCRIKIRHCIGLQSLkflEELPIAKVMKDYLK 325
Cdd:cd03735     4 RPLQELCRKSIVATFGRENL---ARIPLNPVLKDYLK 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 59-88 5.34e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1951390844   59 NGWTLLHFSAAKGKERCVRVFLEHGADPTV 88
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 94-116 7.04e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 7.04e-03
                           10        20
                   ....*....|....*....|...
gi 1951390844   94 GFTALHYAAMHGRARIARLMLES 116
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDK 24
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 133-271 7.26e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.94  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 133 PLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLA-----------IIRERSSC-----VRILLD--HSANIDIQNG 194
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIIckepnklgmkeMIRSINKCsvfytLVAIKDafNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951390844 195 FLLRYavIKGNHS------------------YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCAQMLYMYGADTNTR 256
Cdd:PHA02878  120 ILTNR--YKNIQTidlvyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIP 197

                         170
                  ....*....|....*
gi 1951390844 257 NYEGQTPVAVSVSMS 271
Cdd:PHA02878  198 DKTNNSPLHHAVKHY 212
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 162-191 9.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 9.45e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1951390844  162 KGTTPLQLAIIRERSSCVRILLDHSANIDI 191
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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