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Conserved domains on  [gi|1953413376|ref|XP_038532214|]
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ankyrin repeat and SOCS box protein 16 [Canis lupus familiaris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-327 1.43e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.98  E-value: 1.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 108 KTKQTAPLTIAAARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVP 186
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 187 ESLQCAKLLLEAGATVNvaAQDSE-VTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAgaegpgggRQHQA 265
Cdd:COG0666   131 GNLEIVKLLLEAGADVN--AQDNDgNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE--------NGHLE 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953413376 266 AARRLLEAGADARAAGRKRHTPLHNACANGCGALAELLLRHGACAGVPNAAGHTPMDCALQA 327
Cdd:COG0666   201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 406-447 2.37e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


:

Pssm-ID: 239686  Cd Length: 42  Bit Score: 60.97  E-value: 2.37e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953413376 406 NQPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-327 1.43e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.98  E-value: 1.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 108 KTKQTAPLTIAAARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVP 186
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 187 ESLQCAKLLLEAGATVNvaAQDSE-VTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAgaegpgggRQHQA 265
Cdd:COG0666   131 GNLEIVKLLLEAGADVN--AQDNDgNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE--------NGHLE 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953413376 266 AARRLLEAGADARAAGRKRHTPLHNACANGCGALAELLLRHGACAGVPNAAGHTPMDCALQA 327
Cdd:COG0666   201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
Ank_2 pfam12796
Ankyrin repeats (3 copies);
147-239 1.44e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 147 LHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEagaTVNVAAQDSEVTPLHVAAARGLDEHV 226
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 1953413376 227 ALYLERGADVHLR 239
Cdd:pfam12796  78 KLLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 108-250 1.85e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.14  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 108 KTKQTAPLTIAAARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVP 186
Cdd:PHA02878  165 RHKGNTALHYATENKDQRLTELLLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGY 244

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953413376 187 -ESLQCAKLLLEAGATVNVAAQDSEVTPLHVAAArglDEHVA-LYLERGADVHLRTSQGETALNAA 250
Cdd:PHA02878  245 cKDYDILKLLLEHGVDVNAKSYILGLTALHSSIK---SERKLkLLLEYGADINSLNSYKLTPLSSA 307
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 406-447 2.37e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 60.97  E-value: 2.37e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953413376 406 NQPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 407-445 7.21e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.09  E-value: 7.21e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1953413376 407 QPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLL 445
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 143-250 3.44e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.78  E-value: 3.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 143 GRAALHEA---CARAQSDCVRLLLT--------FGAKANVLSEE--GTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDS 209
Cdd:TIGR00870  82 GDTLLHAIsleYVDAVEAILLHLLAafrksgplELANDQYTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPARACGD 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1953413376 210 EVT-------------PLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAA 250
Cdd:TIGR00870 162 FFVksqgvdsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLL 215
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 122-249 2.40e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 49.88  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 122 GYTDCARHLIRQGAELDARVGgRAALHEAC---ARAQSDCVRLLLTFGAKANVLSE-----------EGTTPLHLCTVPE 187
Cdd:cd21882     6 GLLECLRWYLTDSAYQRGATG-KTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENR 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953413376 188 SLQCAKLLLEAGATVNVAA-----QDSEVT-------PLHVAAARGLDEHVALYLERGAD---VHLRTSQGETALNA 249
Cdd:cd21882    85 NLNLVRLLVENGADVSARAtgrffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLHA 161
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 409-447 3.55e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.55  E-value: 3.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1953413376  409 RRLQHLARLAVRAQLGshcrqATARLPLPPVLRDYLLLR 447
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-327 1.43e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.98  E-value: 1.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 108 KTKQTAPLTIAAARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVP 186
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 187 ESLQCAKLLLEAGATVNvaAQDSE-VTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAgaegpgggRQHQA 265
Cdd:COG0666   131 GNLEIVKLLLEAGADVN--AQDNDgNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE--------NGHLE 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953413376 266 AARRLLEAGADARAAGRKRHTPLHNACANGCGALAELLLRHGACAGVPNAAGHTPMDCALQA 327
Cdd:COG0666   201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
112-326 2.22e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 2.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 112 TAPLTIAAARGYTDCARHLIRQGAELDARVGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQC 191
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 192 AKLLLEAGATVNVAAQDSEvTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAgaegpgggRQHQAAARRLL 271
Cdd:COG0666   103 VKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA--------NGNLEIVKLLL 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1953413376 272 EAGADARAAGRKRHTPLHNACANGCGALAELLLRHGACAGVPNAAGHTPMDCALQ 326
Cdd:COG0666   174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
58-252 4.94e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.57  E-value: 4.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376  58 DPAVHNALFSGDLQQVQALfqdedaanmivetvsnqlawsAEQGFWVLTPKTKQTAPLTIAAARGYTDCARHLIRQGAEL 137
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLL---------------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 138 DAR-VGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNvAAQDSEVTPLHV 216
Cdd:COG0666   147 NAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-AKDNDGKTALDL 225

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1953413376 217 AAARGLDEHVALYLERGADVHLRTSQGETALNAACA 252
Cdd:COG0666   226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
130-350 3.93e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 3.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 130 LIRQGAELDARVGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDS 209
Cdd:COG0666     7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 210 EVTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAgaegpgggRQHQAAARRLLEAGADARAAGRKRHTPLH 289
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY--------NGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953413376 290 NACANGCGALAELLLRHGACAGVPNAAGHTPMDCALQavqdapNWEPEVLfAALLDYGAQP 350
Cdd:COG0666   159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE------NGHLEIV-KLLLEAGADV 212
Ank_2 pfam12796
Ankyrin repeats (3 copies);
147-239 1.44e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 147 LHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEagaTVNVAAQDSEVTPLHVAAARGLDEHV 226
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 1953413376 227 ALYLERGADVHLR 239
Cdd:pfam12796  78 KLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
115-204 6.85e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 6.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 115 LTIAAARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQSDCVRLLLTFGAKANVlsEEGTTPLHLCTVPESLQCAK 193
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 1953413376 194 LLLEAGATVNV 204
Cdd:pfam12796  79 LLLEKGADINV 89
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 108-250 1.85e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.14  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 108 KTKQTAPLTIAAARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVP 186
Cdd:PHA02878  165 RHKGNTALHYATENKDQRLTELLLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGY 244

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953413376 187 -ESLQCAKLLLEAGATVNVAAQDSEVTPLHVAAArglDEHVA-LYLERGADVHLRTSQGETALNAA 250
Cdd:PHA02878  245 cKDYDILKLLLEHGVDVNAKSYILGLTALHSSIK---SERKLkLLLEYGADINSLNSYKLTPLSSA 307
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 406-447 2.37e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 60.97  E-value: 2.37e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953413376 406 NQPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 407-447 2.99e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 60.95  E-value: 2.99e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1953413376 407 QPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 147-332 3.68e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.68  E-value: 3.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 147 LHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDSEvTPLHVAAARGLDEHV 226
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 227 ALYLERGADVHLRTSQGETALNAACAgaegpgggrqHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGA-LAELLLR 305
Cdd:PHA02874  207 KLLIDHGNHIMNKCKNGFTPLHNAII----------HNRSAIELLINNASINDQDIDGSTPLHHAINPPCDIdIIDILLY 276

                         170       180
                  ....*....|....*....|....*..
gi 1953413376 306 HGACAGVPNAAGHTPMDCALQAVQDAP 332
Cdd:PHA02874  277 HKADISIKDNKGENPIDTAFKYINKDP 303
Ank_2 pfam12796
Ankyrin repeats (3 copies);
214-308 3.97e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 3.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 214 LHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAgaegpgggRQHQAAARRLLEagADARAAGRKRHTPLHNACA 293
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAK--------NGHLEIVKLLLE--HADVNLKDNGRTALHYAAR 70

                          90
                  ....*....|....*
gi 1953413376 294 NGCGALAELLLRHGA 308
Cdd:pfam12796  71 SGHLEIVKLLLEKGA 85
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 406-452 5.35e-10

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 54.75  E-value: 5.35e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1953413376 406 NQPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLRVEGRI 452
Cdd:cd03723     1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVL 47
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 407-445 7.21e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.09  E-value: 7.21e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1953413376 407 QPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLL 445
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 99-349 8.07e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.85  E-value: 8.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376  99 EQGFWVLTPKTKQTAPLTIAA-ARGYTDCARHLIRQGAELDAR-VGGRAALHEACARA-QSDCVRLLLTFGAKANVLSEE 175
Cdd:PHA02876  261 DAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKnIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRL 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 176 GTTPLH-LCTVPESLQCAKLLLEAGATVNvaAQD-SEVTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAG 253
Cdd:PHA02876  341 YITPLHqASTLDRNKDIVITLLELGANVN--ARDyCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCG 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 254 AegpgggrQHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGA-LAELLLRHGACAGVPNAAGHTPMDCALqavqdap 332
Cdd:PHA02876  419 T-------NPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLdVIEMLLDNGADVNAINIQNQYPLLIAL------- 484

                         250
                  ....*....|....*..
gi 1953413376 333 nwEPEVLFAALLDYGAQ 349
Cdd:PHA02876  485 --EYHGIVNILLHYGAE 499
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 127-349 9.62e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 9.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 127 ARHLIRQGAELDAR-VGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHlCTVP------------------- 186
Cdd:PHA02876  161 AEMLLEGGADVNAKdIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLE-CAVDsknidtikaiidnrsnink 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 187 -----------ESLQCAKLLLEAGATVNvAAQDSEVTPLHVAA-ARGLDEHVALYLERGADVHLRTSQGETALNAACAGA 254
Cdd:PHA02876  240 ndlsllkairnEDLETSLLLYDAGFSVN-SIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 255 egpgggrQHQAAARRLLEAGADARAAGRKRHTPLHNACA-NGCGALAELLLRHGACAGVPNAAGHTPMDCAlqAVQDAPn 333
Cdd:PHA02876  319 -------YDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYA--AVRNNV- 388

                         250
                  ....*....|....*.
gi 1953413376 334 wepeVLFAALLDYGAQ 349
Cdd:PHA02876  389 ----VIINTLLDYGAD 400
Ank_2 pfam12796
Ankyrin repeats (3 copies);
114-171 6.40e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 6.40e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1953413376 114 PLTIAAARGYTDCARHLIRQgAELDARVGGRAALHEACARAQSDCVRLLLTFGAKANV 171
Cdd:pfam12796  33 ALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 124-291 1.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 124 TDCARHLIRQGAELDA--RVGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGAT 201
Cdd:PHA02878  147 AEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 202 VNvAAQDSEVTPLHVAAARGLD-EHVALYLERGADVHLRTS-QGETALNAACagaegpgggrQHQAAARRLLEAGADARA 279
Cdd:PHA02878  227 TD-ARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAKSYiLGLTALHSSI----------KSERKLKLLLEYGADINS 295

                         170
                  ....*....|..
gi 1953413376 280 AGRKRHTPLHNA 291
Cdd:PHA02878  296 LNSYKLTPLSSA 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 149-325 1.20e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 149 EACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLC---TVPESLQCAKLLLEAGATVNvAAQDSEVTPLHVAAARGLDEH 225
Cdd:PHA03095   20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYlhySSEKVKDIVRLLLEAGADVN-APERCGFTPLHLYLYNATTLD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 226 V-ALYLERGADVHLRTSQGETALnaacagaegpgggrqhqaaarrlleagadaraagrkrHTPLHNACANGCgaLAELLL 304
Cdd:PHA03095   99 ViKLLIKAGADVNAKDKVGRTPL-------------------------------------HVYLSGFNINPK--VIRLLL 139

                         170       180
                  ....*....|....*....|.
gi 1953413376 305 RHGACAGVPNAAGHTPMDCAL 325
Cdd:PHA03095  140 RKGADVNALDLYGMTPLAVLL 160
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 155-326 2.35e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 155 QSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVaAQDSEVTPLHVAAARGLDEHVALYLERGA 234
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 235 DVHLRTSQGETAL-NAACAGaegpgggrqHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGALAelLLRHGACAGVP 313
Cdd:PHA02874  182 YANVKDNNGESPLhNAAEYG---------DYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASINDQ 250

                         170
                  ....*....|...
gi 1953413376 314 NAAGHTPMDCALQ 326
Cdd:PHA02874  251 DIDGSTPLHHAIN 263
PHA03095 PHA03095
ankyrin-like protein; Provisional
 130-305 2.75e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 2.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 130 LIRQGAELDARVG-GRAALHeACARAQS---DCVRLLLTFGAKANVLSEEGTTPLHLCTV-----PESLqcaKLLLEAGA 200
Cdd:PHA03095  103 LIKAGADVNAKDKvGRTPLH-VYLSGFNinpKVIRLLLRKGADVNALDLYGMTPLAVLLKsrnanVELL---RLLIDAGA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 201 TV----------------------------------NVAAQDSEVTPLHVAAARGL--DEHVALYLERGADVHLRTSQGE 244
Cdd:PHA03095  179 DVyavddrfrsllhhhlqsfkprarivreliragcdPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNRYGQ 258

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953413376 245 TALN-AACAGaegpgggrqHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGALAELLLR 305
Cdd:PHA03095  259 TPLHyAAVFN---------NPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 144-350 3.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.30  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 144 RAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDSEvTPLHVAAARGLD 223
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE-SELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 224 EHVALYLERGA---DVHLRtsQGETALNAACAgaegpgggRQHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGALA 300
Cdd:PHA02875   82 KAVEELLDLGKfadDVFYK--DGMTPLHLATI--------LKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1953413376 301 ELLLRHGACAGVPNAAGHTPMDCALQAVQDApnwepevLFAALLDYGAQP 350
Cdd:PHA02875  152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIA-------ICKMLLDSGANI 194
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 143-250 3.44e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.78  E-value: 3.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 143 GRAALHEA---CARAQSDCVRLLLT--------FGAKANVLSEE--GTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDS 209
Cdd:TIGR00870  82 GDTLLHAIsleYVDAVEAILLHLLAafrksgplELANDQYTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPARACGD 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1953413376 210 EVT-------------PLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAA 250
Cdd:TIGR00870 162 FFVksqgvdsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLL 215
PHA03095 PHA03095
ankyrin-like protein; Provisional
 128-249 5.07e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 5.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 128 RHLIRQGAELDARVG-GRAALHEACARAQSDC---VRLLLTFGAKANVLSEEGTTPLHLC-TVPESLQCAKLLLEAGATV 202
Cdd:PHA03095   31 RRLLAAGADVNFRGEyGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADV 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1953413376 203 NVAaqdSEV--TPLHVaAARGLDEH---VALYLERGADVHLRTSQGETALNA 249
Cdd:PHA03095  111 NAK---DKVgrTPLHV-YLSGFNINpkvIRLLLRKGADVNALDLYGMTPLAV 158
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 61-251 1.78e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376  61 VHNALFSGDLQQVQALFQDEDAANMIVetvsnqlawsaeqgfwvltpKTKQTAPLTIAAARGYTDCARHLIRQGAELDAR 140
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVF--------------------YKDGMTPLHLATILKKLDIMKLLIARGADPDIP 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 141 VGGR-AALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDSEVTPLHVAAA 219
Cdd:PHA02875  132 NTDKfSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIE 211

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1953413376 220 RGLDEHVALYLERGADVHLRTS-QGE--TALNAAC 251
Cdd:PHA02875  212 NNKIDIVRLFIKRGADCNIMFMiEGEecTILDMIC 246
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 122-249 2.40e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 49.88  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 122 GYTDCARHLIRQGAELDARVGgRAALHEAC---ARAQSDCVRLLLTFGAKANVLSE-----------EGTTPLHLCTVPE 187
Cdd:cd21882     6 GLLECLRWYLTDSAYQRGATG-KTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENR 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953413376 188 SLQCAKLLLEAGATVNVAA-----QDSEVT-------PLHVAAARGLDEHVALYLERGAD---VHLRTSQGETALNA 249
Cdd:cd21882    85 NLNLVRLLVENGADVSARAtgrffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLHA 161
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 109-236 3.28e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 109 TKQTAPLTIAAARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQSDCVRLLLTFGAkanvLSEEGTTPLHLCTVPE 187
Cdd:PLN03192  556 SKGRTPLHIAASKGYEDCVLVLLKHACNVHIRdANGNTALWNAISAKHHKIFRILYHFAS----ISDPHAAGDLLCTAAK 631

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1953413376 188 --SLQCAKLLLEAGatVNVAAQDSE-VTPLHVAAARGLDEHVALYLERGADV 236
Cdd:PLN03192  632 rnDLTAMKELLKQG--LNVDSEDHQgATALQVAMAEDHVDMVRLLIMNGADV 681
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 119-196 3.38e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 3.38e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953413376 119 AARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLL 196
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRdYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 409-447 3.55e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.55  E-value: 3.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1953413376  409 RRLQHLARLAVRAQLGshcrqATARLPLPPVLRDYLLLR 447
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 406-445 9.92e-06

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 42.20  E-value: 9.92e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953413376 406 NQPRRLQHLARLAVRAQLGshcRQATARLPLPPVLRDYLL 445
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTR---RDLIDQLPLPRRLKDYLK 37
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 149-230 1.04e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 149 EACARAQS-DCV--RLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDSEvTPLHVAAARGLDEH 225
Cdd:PTZ00322   85 ELCQLAASgDAVgaRILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK-TPLELAEENGFREV 163


                  ....*
gi 1953413376 226 VALYL 230
Cdd:PTZ00322  164 VQLLS 168
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 159-236 1.39e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 1.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953413376 159 VRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNVaAQDSEVTPLHVAAARGLDEHVALYLERGADV 236
Cdd:PHA03100  175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 155-255 4.54e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 45.94  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 155 QSDCVRLLLTFGAKANVLSE-----------EGTTPLHLCTVPESLQCAKLLLEAGATVNVAAQDSEV------------ 211
Cdd:cd22193    44 TNDTIRILLDIAEKTDNLKRfinaeytdeyyEGQTALHIAIERRQGDIVALLVENGADVHAHAKGRFFqpkyqgegfyfg 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1953413376 212 -TPLHVAAARGLDEHVALYLE---RGADVHLRTSQGETALNAACAGAE 255
Cdd:cd22193   124 eLPLSLAACTNQPDIVQYLLEnehQPADIEAQDSRGNTVLHALVTVAD 171
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 114-247 5.38e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 114 PLTIAAARGYTDCARHLIRQ-GAELDAR-VGGRAALHEA-------CARAQSDCVRLLLtfgaKANVLSE--EGTTPLHL 182
Cdd:cd22192    20 PLLLAAKENDVQAIKKLLKCpSCDLFQRgALGETALHVAalydnleAAVVLMEAAPELV----NEPMTSDlyQGETALHI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 183 CTVPESLQCAKLLLEAGATVNVAaqdsEVT-----------------PLHVAAARGLDEHVALYLERGADVHLRTSQGET 245
Cdd:cd22192    96 AVVNQNLNLVRELIARGADVVSP----RATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNT 171


                  ..
gi 1953413376 246 AL 247
Cdd:cd22192   172 VL 173
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 195-253 5.69e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 5.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953413376 195 LLEAGATVNVAaqDSE-VTPLHVAAARGLDEHVALYLERGADVHLRTSQGETAL-NAACAG 253
Cdd:PLN03192  544 LLKAKLDPDIG--DSKgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwNAISAK 602
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 407-445 8.19e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 39.97  E-value: 8.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1953413376  407 QPRRLQHLARLAVRAQLGSHcrqATARLPLPPVLRDYLL 445
Cdd:smart00253   6 NVPSLQHLCRFTIRRCTRTD---QIKTLPLPPKLKDYLS 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 159-308 8.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 8.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 159 VRLLLTFGAKANVLSEEGTTPLHLC--TVPESLQCAKLLLEAGATVNVAAQDSEvTPLHVAAARGLDEH--VALYLERGA 234
Cdd:PHA03100   89 VKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGE-NLLHLYLESNKIDLkiLKLLIDKGV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 235 DVHLRTS----------------QGETALNAACAgaegpgggRQHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGA 298
Cdd:PHA03100  168 DINAKNRvnyllsygvpinikdvYGFTPLHYAVY--------NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                         170
                  ....*....|
gi 1953413376 299 LAELLLRHGA 308
Cdd:PHA03100  240 IFKLLLNNGP 249
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 99-217 9.99e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 9.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376  99 EQGFWVLTPKTKQTAPLTIAAARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGT 177
Cdd:PHA02874  112 DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEdDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1953413376 178 TPLHLCTVPESLQCAKLLLEAGATVNVAAQDSeVTPLHVA 217
Cdd:PHA02874  192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNG-FTPLHNA 230
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 407-447 1.47e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 39.23  E-value: 1.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1953413376 407 QPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03719     2 EPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
143-196 1.78e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.78e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1953413376 143 GRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLL 196
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 408-447 2.21e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 39.04  E-value: 2.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1953413376 408 PRRLQHLARLAVRAQLGSH--CRQATA-RLPLPPVLRDYLLLR 447
Cdd:cd03731     3 PRPLKHLCRLKIRKLMGLQklQQPSSMkKLPLPPALKRYILYK 45
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 187-250 2.59e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953413376 187 ESLQCAKLLLEAGATVNvAAQDSEVTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAA 250
Cdd:PHA02876  156 DELLIAEMLLEGGADVN-AKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
Ank_5 pfam13857
Ankyrin repeats (many copies);
195-247 3.50e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 3.50e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1953413376 195 LLEAGATVNVAAQDSEVTPLHVAAARGLDEHVALYLERGADVHLRTSQGETAL 247
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 130-204 6.36e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 6.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953413376 130 LIRQGAELDAR-VGGRAALHEACARAQSDCVRLLLTFGAKANVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNV 204
Cdd:PHA03100  178 LLSYGVPINIKdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 407-447 8.47e-04

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 37.13  E-value: 8.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953413376 407 QPRRLQHLARLAVRAQLG-SHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03727     2 APGTLKALARYAVRRSLGvQYLPEAVKQLPLPRSVKEYLLLL 43
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 408-447 1.52e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 36.75  E-value: 1.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1953413376 408 PRRLQHLARLAVRAQLGS---HCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03730     3 PRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 218-309 1.76e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 218 AARGLDEHVALYLERGADVHLRTSQGETALNAACAGAegpgggrqHQAAARRLLEAGADARAAGRKRHTPLHNACANGCG 297
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANG--------HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161

                          90
                  ....*....|..
gi 1953413376 298 ALAELLLRHGAC 309
Cdd:PTZ00322  162 EVVQLLSRHSQC 173
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 407-447 1.81e-03

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 36.13  E-value: 1.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1953413376 407 QPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYLLLR 447
Cdd:cd03718     2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 145-250 2.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 145 AALHEACARAQSDCVRLLLTFGAKA----NVLSEEGTTP--LHLCTVpESLQCA--------KLLLEAGATVNVAAQDsE 210
Cdd:PTZ00322   38 AAIQEEIARIDTHLEALEATENKDAtpdhNLTTEEVIDPvvAHMLTV-ELCQLAasgdavgaRILLTGGADPNCRDYD-G 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1953413376 211 VTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAA 250
Cdd:PTZ00322  116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
Ank_2 pfam12796
Ankyrin repeats (3 copies);
263-326 2.64e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 2.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953413376 263 HQAA-------ARRLLEAGADARAAGRKRHTPLHNACANGCGALAELLLRHGACAGVPNaaGHTPMDCALQ 326
Cdd:pfam12796   2 HLAAkngnlelVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAAR 70
SOCS_SOCS1 cd03735
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the ...
 409-444 3.62e-03

SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. SOCS1 has a dual function as a direct potent JAK kinase inhibitor and as a component of an E3 ubiquitin-ligase complex recruiting substrates to the protein degradation machinery.


Pssm-ID: 239704  Cd Length: 43  Bit Score: 35.28  E-value: 3.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1953413376 409 RRLQHLARLAVRAQLGshcRQATARLPLPPVLRDYL 444
Cdd:cd03735     4 RPLQELCRKSIVATFG---RENLARIPLNPVLKDYL 36
Ank_4 pfam13637
Ankyrin repeats (many copies);
210-253 4.07e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 4.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1953413376 210 EVTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAG 253
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
PHA02798 PHA02798
ankyrin-like protein; Provisional
 157-247 4.53e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.43  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 157 DCVRLLLTFGAKANVLSEEGTTPlhLCTV-------PESLQCAKLLLEAGATVNVAAQDSEvTPLHVAAARGL---DEHV 226
Cdd:PHA02798   52 DIVKLFINLGANVNGLDNEYSTP--LCTIlsnikdyKHMLDIVKILIENGADINKKNSDGE-TPLYCLLSNGYinnLEIL 128

                          90       100
                  ....*....|....*....|.
gi 1953413376 227 ALYLERGADVHLRTSQGETAL 247
Cdd:PHA02798  129 LFMIENGADTTLLDKDGFTML 149
Ank_5 pfam13857
Ankyrin repeats (many copies);
283-324 5.58e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 5.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953413376 283 KRHTPLHNACANGCGALAELLLRHGACAGVPNAAGHTPMDCA 324
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 407-444 6.08e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 34.82  E-value: 6.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953413376 407 QPRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYL 444
Cdd:cd03726     2 QPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYL 39
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 408-444 6.70e-03

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 34.46  E-value: 6.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1953413376 408 PRRLQHLARLAVRAQLGSHCRQATARLPLPPVLRDYL 444
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 193-350 8.64e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.32  E-value: 8.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 193 KLLLEAGATVNVAAQDSEVTPLHVAAARGLDEHVALYLERGADVHLRTSQGETALNAACAGAEGPGggrqhqaaARRLLE 272
Cdd:PHA02878  151 KLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPI--------VHILLE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953413376 273 AGADARAAGRKRHTPLHNA---CANgcGALAELLLRHGACAGVPNAA-GHTPMDCALQavqdapnwEPEVLfAALLDYGA 348
Cdd:PHA02878  223 NGASTDARDKCGNTPLHISvgyCKD--YDILKLLLEHGVDVNAKSYIlGLTALHSSIK--------SERKL-KLLLEYGA 291


                  ..
gi 1953413376 349 QP 350
Cdd:PHA02878  292 DI 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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