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Conserved domains on  [gi|1953404259|ref|XP_038528349|]
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aquaporin-4 isoform X2 [Canis lupus familiaris]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 2.38e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 250.31  E-value: 2.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259   9 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  88 ISIAKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSV 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259 168 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 2.38e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 250.31  E-value: 2.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259   9 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  88 ISIAKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSV 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259 168 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 14-229 1.57e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 220.20  E-value: 1.57e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTINWGGTEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 93
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  94 VFYVAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLTAGHGLLVELIITFQLVFTIFASCD-SKRTDV 163
Cdd:cd00333    80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953404259 164 TGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:cd00333   160 GGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 18-226 4.25e-67

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 208.69  E-value: 4.25e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  18 AEFLAMLIFVLLSLGSTI---NWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 94
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  95 FYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSVALAIG 172
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953404259 173 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 12-230 4.26e-60

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 191.11  E-value: 4.26e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  12 FWKAVTAEFLAMLIFVLLSLGSTINWGGTekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 91
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  92 KSVFYVAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 163
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953404259 164 TGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-230 1.11e-43

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 149.70  E-value: 1.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTINWGG--TEKPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 90
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  91 AKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVA-L 169
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953404259 170 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 2.38e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 250.31  E-value: 2.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259   9 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  88 ISIAKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSV 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259 168 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 14-229 1.57e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 220.20  E-value: 1.57e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTINWGGTEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 93
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  94 VFYVAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLTAGHGLLVELIITFQLVFTIFASCD-SKRTDV 163
Cdd:cd00333    80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953404259 164 TGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:cd00333   160 GGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 18-226 4.25e-67

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 208.69  E-value: 4.25e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  18 AEFLAMLIFVLLSLGSTI---NWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 94
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  95 FYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSVALAIG 172
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953404259 173 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 12-230 4.26e-60

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 191.11  E-value: 4.26e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  12 FWKAVTAEFLAMLIFVLLSLGSTINWGGTekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 91
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  92 KSVFYVAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 163
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953404259 164 TGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-230 1.11e-43

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 149.70  E-value: 1.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTINWGG--TEKPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 90
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  91 AKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVA-L 169
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953404259 170 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 14-230 8.28e-43

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 147.24  E-value: 8.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTINW-----GGTEKPLPVDMVLISLCFGLSIATMVQCfgHISGGHINPAVTVAMVCTRKI 88
Cdd:PLN00027   21 KAALAEFISTLIFVFAGEGSGMAFnkltdNGSTTPAGLVAAALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  89 SIAKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLTAGHGLLVELIITFQLVFTIFASC-DSKRTDVTGSV 167
Cdd:PLN00027   99 TLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSS---GVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGIIA 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953404259 168 ALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00027  176 PIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 14-230 2.62e-37

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 132.40  E-value: 2.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTINWGGTeKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 93
Cdd:PRK05420    3 KKLAAEFFGTFWLVFGGCGSAVLAAAF-PELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  94 VFYVAAQCLGAIIGAGILYLVTPP----SVVGGLGVTTVHGNLTAGH-----GLLVELIITFQLVFTIFASCDsKRTDVt 164
Cdd:PRK05420   82 VPYIIAQVVGGIAAAAVLYLIASGkagfDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATD-KRAPA- 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953404259 165 GSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNW--ENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PRK05420  160 GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 4-232 9.47e-36

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 129.25  E-value: 9.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259   4 FRGVWTQAFWKAVTAEFLAMLIFVLLSLGSTInwgGTEKPLPVD------MVLISLCFGLSIATMVQCFGHISGGHINPA 77
Cdd:PLN00167   13 FQQSVTRNALRSYLAEFISTFFFVFAAVGSAM---SSRKLMPDAasdpssLLIVAIANAFALSSAVYIAANISGGHVNPA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  78 VTVAMVCTRKISIAKSVFYVAAQCLGAIIGAGILYLVTppsVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCD 157
Cdd:PLN00167   90 VTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGD 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1953404259 158 SKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 232
Cdd:PLN00167  167 PRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00026 PLN00026
aquaporin NIP; Provisional
 14-235 1.10e-31

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 119.58  E-value: 1.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  14 KAVTAEFLAMLIFVLLSLGSTI---NWGGTEKPLPvdmvlISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 90
Cdd:PLN00026   72 RKLGAEFVGTFILIFAATAGPIvnqKYDGAETLIG-----NAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  91 AKSVFYVAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVhgnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSVA-L 169
Cdd:PLN00026  147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSV----STGQAFALEFIITFNLLFVVTAVATDTRA--VGELAgI 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953404259 170 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 235
Cdd:PLN00026  221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 51-254 8.00e-30

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 114.24  E-value: 8.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  51 ISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYVAAQCLGAIIGAGILYL---VTPPSVVGglgvTT 127
Cdd:PLN00182   78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLmfnVTPEAFFG----TT 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259 128 VHGnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSVA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE 206
Cdd:PLN00182  154 PTD--SSGQALVAEIIISFLLMFVISGVATDSRA--VGELAgIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK 229

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1953404259 207 NHWIYWVGPIIGAVLAGGLYEYVFCPDVELKRRLKEA-FSKATQQTKRS 254
Cdd:PLN00182  230 GIWVYIVGPFVGIIAGGFVYNLIRFTDKPLRELTKSAsFLRSVSQKHNA 278
PLN00184 PLN00184
aquaporin NIP1; Provisional
 12-241 1.56e-27

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 108.57  E-value: 1.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  12 FWKAVTAEFLAMLIFVLLSLGSTINwgGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 91
Cdd:PLN00184   53 FLQKLIAEVLGTYFLVFTGCASVVV--NMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  92 KSVFYVAAQCLGAIIGAGILYLV--TPPSVVGG-----LGVTTVHGNLTAghgLLVELIITFQLVFTIFASCDSKRTdvT 164
Cdd:PLN00184  131 QVPAYVISQVIGSTLAAATLRLLfgLDHDVCSGkhdvfIGSSPVGSDLQA---FVMEFIVTFYLMFIISGVATDNRA--I 205

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953404259 165 GSVA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVELKRRLK 241
Cdd:PLN00184  206 GELAgLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDKPLREITK 283
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 56-226 3.40e-21

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 90.69  E-value: 3.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  56 GLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYVAAQCLGAIIG---AGILYLVTPPsvvgglgVTTVHGNL 132
Cdd:PLN00183   86 GLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITAQTVGSVLAtyvGVSVYGVKAD-------LMTTKPAQ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259 133 TAGHGLLVELIITFQLVFtIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYW 212
Cdd:PLN00183  159 GCSSAFWVEFIATFIVMF-LAASLTSQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYI 237

                         170
                  ....*....|....
gi 1953404259 213 VGPIIGAVLAGGLY 226
Cdd:PLN00183  238 TAPTIGAVAGALMF 251
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 13-235 4.39e-21

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 90.96  E-value: 4.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  13 WKAVTAEFLAMliFVLLSLGSTINwgGTEKPLPVDMVLISLCFGLSIATMVQCF--GHISGGHINPAVTVAMVCTRKISI 90
Cdd:PTZ00016   50 VREYVAEFLGT--FVLLFFGEGVV--ATTHTVGNNGDYLAITIGWGLGVTFGLLvsAGISGGHLNPAVTLGNAVFGKFPW 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259  91 AKSVFYVAAQCLGAIIGAGILYLV----------------TPPSVVGGLGVTTVHGNLTagHGLLVELIITFQLVFTIFA 154
Cdd:PTZ00016  126 KKLPGYFVAQLLGAFVGAACVYGLyygffkdhgipelpweTMANGFAGVFATYPREGNF--YAIFSELILTAILLLVILA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953404259 155 SCDSKRTDVTGSVALAIGFSV-AIGHLFAINyTGASMNPARSFGP----AVIMGN----WENH--WIYWVGPIIGAVLAG 223
Cdd:PTZ00016  204 ITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevftKDNYyfWVPLVAPFVGAVLGM 282

                         250
                  ....*....|..
gi 1953404259 224 GLYEYVFCPDVE 235
Cdd:PTZ00016  283 FLYDKFIPPLIE 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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