|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin-like super family |
cl49609 |
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ... |
1390-1512 |
8.73e-75 |
|
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.
The actual alignment was detected with superfamily member cd23465:
Pssm-ID: 483949 Cd Length: 136 Bit Score: 244.39 E-value: 8.73e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1390 QRRVYFRLWNAALRGFLAVPDHVEDMKAGRVVVSEPQAGGSCIWYYEDGLLKN--------QVIGPPSPGSKAVLWAESR 1461
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNqmaptmslQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1952703796 1462 LPRQTWSISESGHICSQMFEGRILDVKGGRGYDRDHVVLWEPTKDRASQLW 1512
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIW 131
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1033-1119 |
3.63e-35 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
:
Pssm-ID: 459639 Cd Length: 82 Bit Score: 128.77 E-value: 3.63e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1033 KVVVYEATGFQGQSWEVSRDIYNLQEpedsqSPHLASVGSLRVLGGCWVGYQKAGFRGHQYLLEEGEYADWSHWGGYDEA 1112
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75
|
....*..
gi 1952703796 1113 LTSLRVI 1119
Cdd:pfam00030 76 IGSLRPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1128-1208 |
3.03e-27 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
:
Pssm-ID: 459639 Cd Length: 82 Bit Score: 106.42 E-value: 3.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1128 LVLFEATDFEGHAAEVREALPDVELARHGPHTQAIHVLSGVWVAYQKVGFSGEQYVLEKGVYRTCDDWGAGNSALASLQP 1207
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 1952703796 1208 V 1208
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1308-1388 |
2.90e-24 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
:
Pssm-ID: 459639 Cd Length: 82 Bit Score: 97.95 E-value: 2.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1308 SIFLYGLECFEGKEIELDREVRSLQAEGFNNHVLSLRIKGGVWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1386
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 1952703796 1387 PI 1388
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
939-1019 |
1.73e-21 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
:
Pssm-ID: 459639 Cd Length: 82 Bit Score: 89.86 E-value: 1.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 939 IIVYSEKGLKGEQVELTDALEDTQGLEKPLQAASATVSAGLWLLYPKPSFEDSPCILEPGEYPTLEAWGTSDLRVGSLKP 1018
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 1952703796 1019 M 1019
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1221-1300 |
3.88e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
:
Pssm-ID: 459639 Cd Length: 82 Bit Score: 83.31 E-value: 3.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1221 KIQLFSGPDFLGDHISFEDDQTSLPVSF---QPQSCRVHGGSWILFGEKNFEGDQYILSEGEFPTLTAMGCLSSTVlGSL 1297
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGfnsRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 1952703796 1298 QKV 1300
Cdd:pfam00030 80 RPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
851-930 |
6.13e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
:
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.54 E-value: 6.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 851 KMILFSEPGCQGSSREVWEDTADTSSW---PRVASVRVVRGCWVLYEEPEFRGRKLVVPEGDV----DLGAPGPAwstqg 923
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERgfnSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYpdwsDWGAPNDR----- 75
|
....*..
gi 1952703796 924 IGSVRRV 930
Cdd:pfam00030 76 IGSLRPI 82
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
111-450 |
7.66e-10 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.19 E-value: 7.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 111 RRKEAVDQGDSSPQEPRTEQANPEALARTELLVPLPGPREPSPHPgVSLSSGSPRSLEERRVTRTVQTTVVVgghverRV 190
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP-HALVSATPLPPGPAAARQASPALPAA------PA 2740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 191 NSSVTVGPGPWGEAQPRGRNVVRAVRAVVVSPQAE-GSPTRSQARELLSSLVP-TERSPAASRLPRPTAVVPRNPGLGGP 268
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaAGPPRRLTRPAVASLSEsRESLPSPWDPADPPAAVLAPAAALPP 2820
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 269 GGAASGQLPEPGMAEPKDRS-ALGPAGSSE--DGHPPPNQDVPAAHPEQDQSRAPEVLTRKGASGPTQPSPQISRSHVSL 345
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPpPPGPPPPSLplGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 346 PS-SLGRQTPTPSLDPEHPPEQPAVPTYPRTQLTLKPRV-PQALPSIKREGLTDPSVVTSPPMAKSEVlvtgPGQSLAPs 423
Cdd:PHA03247 2901 PPdQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPWLGALV----PGRVAVP- 2975
|
330 340
....*....|....*....|....*..
gi 1952703796 424 stRRKAVPSSGALSAPSSPGNKLVRDS 450
Cdd:PHA03247 2976 --RFRVPQPAPSREAPASSTPPLTGHS 3000
|
|
| DUF5585 super family |
cl39316 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
324-619 |
1.08e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
The actual alignment was detected with superfamily member pfam17823:
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 324 TRKG-ASGPTQPSPQISRShvSLPSSLGRQTPTPSLDPehPPEQPAVPT--YPRTQLTLKPRVPQALPSIKREGLTDPSV 400
Cdd:pfam17823 102 TREGaADGAASRALAAAAS--SSPSSAAQSLPAAIAAL--PSEAFSAPRaaACRANASAAPRAAIAAASAPHAASPAPRT 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 401 VTSPPMAKSEVLVTGPGQSLAPSSTRRKAVPSSGALSAPSSPGNklvrdsehvPVFSLTQAEVVAGPAAPAASSPKPSKV 480
Cdd:pfam17823 178 AASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGH---------PAAGTALAAVGNSSPAAGTVTAAVGTV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 481 VQAPAGSPSTPKEAVHVTKGdlascpsqdeavegltTFTIPSPQeeeiveGSKVSPIASPTQKELVQDPGAPAAPfSTQT 560
Cdd:pfam17823 249 TPAALATLAAAAGTVASAAG----------------TINMGDPH------ARRLSPAKHMPSDTMARNPAAPMGA-QAQG 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952703796 561 VIAQDTAVPPAPSSEGKVSPSPGGPPASVLIRAEASLESQLVPNSTEGEM---------LPETSREEE 619
Cdd:pfam17823 306 PIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAkepsaspvpVLHTSMIPE 373
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
521-835 |
4.86e-04 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 4.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 521 PSPQEEEIVEGSKVSPIAS-PTQKELVQDPGAPAAPFSTQTVIAQ--DTAVPPAPSSEGKVSPSPGGPPASVliRAEASL 597
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSePAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 598 ESQLVPNSTEGEMLPETSREEEEVALAADMEMFLDTLRSMEPPEILRTHRLPraPRSSYLAMYATLPAIE---EDQPGPW 674
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADPPPPPptpEPAPHAL 2715
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 675 VLGPSPQEVPTLEGKEEEEEEEEEPENPylsddeklqrrqEKAGP-SPSWDSRPARPPQVSCSPlemmkkhvADAKGPHP 753
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPA------------VPAGPaTPGGPARPARPPTTAGPP--------APAPPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 754 ELGPEWQASSRPTSRLGGSLlfSGLVSATQEAPISEPLGTKLSALPPHVTPGTRKVPGQLPLLCSERPPPEKPACAQPLA 833
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESR--ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
|
..
gi 1952703796 834 GW 835
Cdd:PHA03247 2854 GS 2855
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin_CRYBG2 |
cd23465 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1390-1512 |
8.73e-75 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467343 Cd Length: 136 Bit Score: 244.39 E-value: 8.73e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1390 QRRVYFRLWNAALRGFLAVPDHVEDMKAGRVVVSEPQAGGSCIWYYEDGLLKN--------QVIGPPSPGSKAVLWAESR 1461
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNqmaptmslQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1952703796 1462 LPRQTWSISESGHICSQMFEGRILDVKGGRGYDRDHVVLWEPTKDRASQLW 1512
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIW 131
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1033-1119 |
3.63e-35 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 128.77 E-value: 3.63e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1033 KVVVYEATGFQGQSWEVSRDIYNLQEpedsqSPHLASVGSLRVLGGCWVGYQKAGFRGHQYLLEEGEYADWSHWGGYDEA 1112
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75
|
....*..
gi 1952703796 1113 LTSLRVI 1119
Cdd:pfam00030 76 IGSLRPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1128-1208 |
3.03e-27 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 106.42 E-value: 3.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1128 LVLFEATDFEGHAAEVREALPDVELARHGPHTQAIHVLSGVWVAYQKVGFSGEQYVLEKGVYRTCDDWGAGNSALASLQP 1207
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 1952703796 1208 V 1208
Cdd:pfam00030 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1033-1119 |
3.82e-27 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 106.05 E-value: 3.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1033 KVVVYEATGFQGQSWEVSRDIYNLQEpedsqSPHLASVGSLRVLGGCWVGYQKAGFRGHQYLLEEGEYADWSHWGGYDEA 1112
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQD-----YGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75
|
....*..
gi 1952703796 1113 LTSLRVI 1119
Cdd:smart00247 76 ISSIRRI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1308-1388 |
2.90e-24 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 97.95 E-value: 2.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1308 SIFLYGLECFEGKEIELDREVRSLQAEGFNNHVLSLRIKGGVWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1386
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 1952703796 1387 PI 1388
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
939-1019 |
1.73e-21 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 89.86 E-value: 1.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 939 IIVYSEKGLKGEQVELTDALEDTQGLEKPLQAASATVSAGLWLLYPKPSFEDSPCILEPGEYPTLEAWGTSDLRVGSLKP 1018
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 1952703796 1019 M 1019
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1221-1300 |
3.88e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 83.31 E-value: 3.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1221 KIQLFSGPDFLGDHISFEDDQTSLPVSF---QPQSCRVHGGSWILFGEKNFEGDQYILSEGEFPTLTAMGCLSSTVlGSL 1297
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGfnsRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 1952703796 1298 QKV 1300
Cdd:pfam00030 80 RPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
851-930 |
6.13e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.54 E-value: 6.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 851 KMILFSEPGCQGSSREVWEDTADTSSW---PRVASVRVVRGCWVLYEEPEFRGRKLVVPEGDV----DLGAPGPAwstqg 923
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERgfnSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYpdwsDWGAPNDR----- 75
|
....*..
gi 1952703796 924 IGSVRRV 930
Cdd:pfam00030 76 IGSLRPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1309-1388 |
2.22e-16 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 75.24 E-value: 2.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1309 IFLYGLECFEGKEIELDREVRSLQAEGFNNHVLSLRIKGGVWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1387
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81
|
.
gi 1952703796 1388 I 1388
Cdd:smart00247 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1128-1208 |
3.30e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 72.16 E-value: 3.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1128 LVLFEATDFEGHAAEVREALPDVELARHGPHTQAIHVLSGVWVAYQKVGFSGEQYVLEKGVYRTCDDWGAGNSALASLQP 1207
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 1952703796 1208 V 1208
Cdd:smart00247 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
851-930 |
6.53e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.39 E-value: 6.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 851 KMILFSEPGCQGSSREVWEDTA---DTSSWPRVASVRVVRGCWVLYEEPEFRGRKLVVPEGDV----DLGAPGPAwstqg 923
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPslqDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYpdyqEWGGFNDQ----- 75
|
....*..
gi 1952703796 924 IGSVRRV 930
Cdd:smart00247 76 ISSIRRI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1221-1297 |
3.43e-14 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 69.07 E-value: 3.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1221 KIQLFSGPDFLGDHISFEDDQTSLPVSF---QPQSCRVHGGSWILFGEKNFEGDQYILSEGEFPTLTAMGCLSSTVlGSL 1297
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQDYGsrdNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
111-450 |
7.66e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.19 E-value: 7.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 111 RRKEAVDQGDSSPQEPRTEQANPEALARTELLVPLPGPREPSPHPgVSLSSGSPRSLEERRVTRTVQTTVVVgghverRV 190
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP-HALVSATPLPPGPAAARQASPALPAA------PA 2740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 191 NSSVTVGPGPWGEAQPRGRNVVRAVRAVVVSPQAE-GSPTRSQARELLSSLVP-TERSPAASRLPRPTAVVPRNPGLGGP 268
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaAGPPRRLTRPAVASLSEsRESLPSPWDPADPPAAVLAPAAALPP 2820
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 269 GGAASGQLPEPGMAEPKDRS-ALGPAGSSE--DGHPPPNQDVPAAHPEQDQSRAPEVLTRKGASGPTQPSPQISRSHVSL 345
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPpPPGPPPPSLplGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 346 PS-SLGRQTPTPSLDPEHPPEQPAVPTYPRTQLTLKPRV-PQALPSIKREGLTDPSVVTSPPMAKSEVlvtgPGQSLAPs 423
Cdd:PHA03247 2901 PPdQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPWLGALV----PGRVAVP- 2975
|
330 340
....*....|....*....|....*..
gi 1952703796 424 stRRKAVPSSGALSAPSSPGNKLVRDS 450
Cdd:PHA03247 2976 --RFRVPQPAPSREAPASSTPPLTGHS 3000
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
939-1019 |
1.84e-09 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 55.59 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 939 IIVYSEKGLKGEQVELTDALEDTQGLEKPLQAASATVSAGLWLLYPKPSFEDSPCILEPGEYPTLEAWGTSDLRVGSLKP 1018
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 1952703796 1019 M 1019
Cdd:smart00247 82 I 82
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
238-584 |
5.99e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 54.54 E-value: 5.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 238 SSLVPTERSPAASRLPRPTAVVPRNPGLGGPGGAASGQLPEPGM----AEPKDRSALGPAGSSEDGHPPPNQDVPAAHPE 313
Cdd:pfam05109 451 STHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngTESKAPDMTSPTSAVTTPTPNATSPTPAVTTP 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 314 QDQSRAPEVLTRKGASGPTQPSPQISRSHVSLPSSLGRQTpTPSLDPEHPPEQPAVPTYPRTQLTLKPRVPQALPSIKRE 393
Cdd:pfam05109 531 TPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNAT-IPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTL 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 394 GLTDPS-VVTSPPMAKSEVLVTGPGQSLAPSSTRRKAVPSSGALS-APSSPGNKlvrdSEHVPVfsLTQAEVVAGpaapa 471
Cdd:pfam05109 610 GGTSSTpVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETlSPSTSDNS----TSHMPL--LTSAHPTGG----- 678
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 472 asspkpSKVVQAPAGSPSTPkeavHVTKGDLASCPSQDEAVEGL-TTFTIPSPQEEEIVEGSKVSPIASPTqkelvqdpg 550
Cdd:pfam05109 679 ------ENITQVTPASTSTH----HVSTSSPAPRPGTTSQASGPgNSSTSTKPGEVNVTKGTPPKNATSPQ--------- 739
|
330 340 350
....*....|....*....|....*....|....
gi 1952703796 551 APAapfstqtviAQDTAVPPAPSSEGKVSPSPGG 584
Cdd:pfam05109 740 APS---------GQKTAVPTVTSTGGKANSTTGG 764
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
324-619 |
1.08e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 324 TRKG-ASGPTQPSPQISRShvSLPSSLGRQTPTPSLDPehPPEQPAVPT--YPRTQLTLKPRVPQALPSIKREGLTDPSV 400
Cdd:pfam17823 102 TREGaADGAASRALAAAAS--SSPSSAAQSLPAAIAAL--PSEAFSAPRaaACRANASAAPRAAIAAASAPHAASPAPRT 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 401 VTSPPMAKSEVLVTGPGQSLAPSSTRRKAVPSSGALSAPSSPGNklvrdsehvPVFSLTQAEVVAGPAAPAASSPKPSKV 480
Cdd:pfam17823 178 AASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGH---------PAAGTALAAVGNSSPAAGTVTAAVGTV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 481 VQAPAGSPSTPKEAVHVTKGdlascpsqdeavegltTFTIPSPQeeeiveGSKVSPIASPTQKELVQDPGAPAAPfSTQT 560
Cdd:pfam17823 249 TPAALATLAAAAGTVASAAG----------------TINMGDPH------ARRLSPAKHMPSDTMARNPAAPMGA-QAQG 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952703796 561 VIAQDTAVPPAPSSEGKVSPSPGGPPASVLIRAEASLESQLVPNSTEGEM---------LPETSREEE 619
Cdd:pfam17823 306 PIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAkepsaspvpVLHTSMIPE 373
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
277-730 |
3.69e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 45.45 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 277 PEPGMAEPKdrsalGPA-GSSEDGHPPPNQ--DVPAAHPEQDQSRAPEVLTRKGASGPTQPS--PQISRShvslpsslgr 351
Cdd:PTZ00449 514 PEASGLPPK-----APGdKEGEEGEHEDSKesDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiPTLSKK---------- 578
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 352 qtPTPSLDPEHP--PEQPAVPTYPRTqltlkPRVPQALPSIKREGLTDpsVVTSPPMAKSEVLVTGPGQSLAPSSTRRKA 429
Cdd:PTZ00449 579 --PEFPKDPKHPkdPEEPKKPKRPRS-----AQRPTRPKSPKLPELLD--IPKSPKRPESPKSPKRPPPPQRPSSPERPE 649
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 430 VPSSgaLSAPSSPgnklvrDSEHVPVFSLTQAEVVAGPAAPAASSPKPSKVVQAPAGSPSTPKEAVHVTKGDLASCPSqd 509
Cdd:PTZ00449 650 GPKI--IKSPKPP------KSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPR-- 719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 510 eaveglttftiPSPQEEEIVEGSKVSPIASPTQkELVQDPGAPAAPFSTQTVIAQDTAVPPAPSSEGKVSPSPG-----G 584
Cdd:PTZ00449 720 -----------PLPPKLPRDEEFPFEPIGDPDA-EQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDihaetG 787
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 585 PPASVLIRAEASLESQLVPNSTEGEMlPETSREEEEVALAA-DMEMfldtlrsmEPPEILR--THRLPRAPRSSYLAMYA 661
Cdd:PTZ00449 788 EPDEAMKRPDSPSEHEDKPPGDHPSL-PKKRHRLDGLALSTtDLES--------DAGRIAKdaSGKIVKLKRSKSFDDLT 858
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952703796 662 TLPAIEEDQPgpwvlgPSPQEVPTLEGKEEEEEEEEEPENPYLSddEKLQRRQEKAGPSPSWDSRPARP 730
Cdd:PTZ00449 859 TVEEAEEMGA------EARKIVVDDDGTEADDEDTHPPEEKHKS--EVRRRRPPKKPSKPKKPSKPKKP 919
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
521-835 |
4.86e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 4.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 521 PSPQEEEIVEGSKVSPIAS-PTQKELVQDPGAPAAPFSTQTVIAQ--DTAVPPAPSSEGKVSPSPGGPPASVliRAEASL 597
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSePAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 598 ESQLVPNSTEGEMLPETSREEEEVALAADMEMFLDTLRSMEPPEILRTHRLPraPRSSYLAMYATLPAIE---EDQPGPW 674
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADPPPPPptpEPAPHAL 2715
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 675 VLGPSPQEVPTLEGKEEEEEEEEEPENPylsddeklqrrqEKAGP-SPSWDSRPARPPQVSCSPlemmkkhvADAKGPHP 753
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPA------------VPAGPaTPGGPARPARPPTTAGPP--------APAPPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 754 ELGPEWQASSRPTSRLGGSLlfSGLVSATQEAPISEPLGTKLSALPPHVTPGTRKVPGQLPLLCSERPPPEKPACAQPLA 833
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESR--ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
|
..
gi 1952703796 834 GW 835
Cdd:PHA03247 2854 GS 2855
|
|
| Ricin_B_lectin |
pfam00652 |
Ricin-type beta-trefoil lectin domain; |
1433-1512 |
8.85e-04 |
|
Ricin-type beta-trefoil lectin domain;
Pssm-ID: 395527 [Multi-domain] Cd Length: 126 Bit Score: 40.98 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1433 W-YYEDGLLKNQV------IGPPSPGSKAVLWA-ESRLPRQTWSISESGHICSQMFEGRILDVKGGrGYDRDHVVLWEPT 1504
Cdd:pfam00652 40 WtLTGDGTIRSVAsdlcldVGSTADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWTCD 118
|
....*...
gi 1952703796 1505 KDRASQLW 1512
Cdd:pfam00652 119 SGNPNQQW 126
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin_CRYBG2 |
cd23465 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1390-1512 |
8.73e-75 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467343 Cd Length: 136 Bit Score: 244.39 E-value: 8.73e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1390 QRRVYFRLWNAALRGFLAVPDHVEDMKAGRVVVSEPQAGGSCIWYYEDGLLKN--------QVIGPPSPGSKAVLWAESR 1461
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNqmaptmslQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1952703796 1462 LPRQTWSISESGHICSQMFEGRILDVKGGRGYDRDHVVLWEPTKDRASQLW 1512
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIW 131
|
|
| beta-trefoil_Ricin_CRYBG |
cd23430 |
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin ... |
1393-1512 |
4.69e-60 |
|
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin domain-containing protein (CRYBG) family; The CRYBG family includes three members: CRYBG1, CRYBG2, and CRYBG3/vlAKAP. CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG2 is also called absent in melanoma 1-like protein (AIM1L). CRYBG3/vlAKAP, also called very large A-kinase anchor protein, is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). CRYBG proteins belong to the beta/gamma-crystallin family. They all contain a ricin B-type lectin domain with a beta-trefoil fold at the C-terminus. The beta-trefoil fold is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467308 [Multi-domain] Cd Length: 133 Bit Score: 202.05 E-value: 4.69e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1393 VYFRLWNAALRGFLAVPDHVEDMKAGRVVVSEPQAGGSCIWYYEDGLLKNQ--------VIGPPS-PGSKAVLWAESRLP 1463
Cdd:cd23430 1 VYFRLRNKATGLFLSVNGNLEDLKLLRVQVMPDVGADDQIWYYQEGLIKCRiaedccltVIGSLVtPGSKVGLWLEQNAD 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1952703796 1464 RQTWSISESGHICSQMFEGRILDVKGGRGYDRDHVVLWEPTKDRASQLW 1512
Cdd:cd23430 81 RQFWSLKSDGRIYSKLKPNLVLDVKGGTQYDQNHVILNTPSEEKFTQVW 129
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1033-1119 |
3.63e-35 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 128.77 E-value: 3.63e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1033 KVVVYEATGFQGQSWEVSRDIYNLQEpedsqSPHLASVGSLRVLGGCWVGYQKAGFRGHQYLLEEGEYADWSHWGGYDEA 1112
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75
|
....*..
gi 1952703796 1113 LTSLRVI 1119
Cdd:pfam00030 76 IGSLRPI 82
|
|
| beta-trefoil_Ricin_vlAKAP |
cd23463 |
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein ... |
1390-1512 |
1.67e-28 |
|
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein (vlAKAP) and similar proteins; vlAKAP, also called beta/gamma crystallin domain-containing protein 3 (CRYBG3), is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). vlAKAP belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467341 Cd Length: 136 Bit Score: 112.15 E-value: 1.67e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1390 QRRVYFRLWNAALRGFLAVPDHVEDMKAGRVVVSepQAGGSC--IWYYEDGLLKNQ-------VIG-PPSPGSKAVLWAE 1459
Cdd:cd23463 1 QPRVYLRIKNRAQGLYLTTEGNLADPRATSVCVS--QYNGKDtqIWYYCRGLLKSKandacldVIGgKDNPGSKVALWTE 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1952703796 1460 SRLPRQTWSISESGHICSQMFEGRILDVKGGRGYDRDHVVLWEPTKDRASQLW 1512
Cdd:cd23463 79 HGKTHQKWRINEDGTISSHLSDDLVLDLKGGNYYDKDHLIVNNPEEDQQTQKW 131
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1128-1208 |
3.03e-27 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 106.42 E-value: 3.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1128 LVLFEATDFEGHAAEVREALPDVELARHGPHTQAIHVLSGVWVAYQKVGFSGEQYVLEKGVYRTCDDWGAGNSALASLQP 1207
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 1952703796 1208 V 1208
Cdd:pfam00030 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1033-1119 |
3.82e-27 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 106.05 E-value: 3.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1033 KVVVYEATGFQGQSWEVSRDIYNLQEpedsqSPHLASVGSLRVLGGCWVGYQKAGFRGHQYLLEEGEYADWSHWGGYDEA 1112
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQD-----YGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75
|
....*..
gi 1952703796 1113 LTSLRVI 1119
Cdd:smart00247 76 ISSIRRI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1308-1388 |
2.90e-24 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 97.95 E-value: 2.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1308 SIFLYGLECFEGKEIELDREVRSLQAEGFNNHVLSLRIKGGVWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1386
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 1952703796 1387 PI 1388
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
939-1019 |
1.73e-21 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 89.86 E-value: 1.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 939 IIVYSEKGLKGEQVELTDALEDTQGLEKPLQAASATVSAGLWLLYPKPSFEDSPCILEPGEYPTLEAWGTSDLRVGSLKP 1018
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 1952703796 1019 M 1019
Cdd:pfam00030 82 I 82
|
|
| beta-trefoil_Ricin_CRYBG1 |
cd23464 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1390-1512 |
4.39e-21 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467342 Cd Length: 137 Bit Score: 90.63 E-value: 4.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1390 QRRVYFRLWNAALRGFLAVPDHVEDMKAGRVVVSEPQAGGSCIWYYEDGLLKNQVI---------GPPSPGSKAVLWAES 1460
Cdd:cd23464 1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAedccletvgNLVTAGSKLGLSLEQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1952703796 1461 RLPRQTWSISESGHICSQMFEGRILDVKGGRGYDRDHVVLWEPTKDRASQLW 1512
Cdd:cd23464 81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRW 132
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1221-1300 |
3.88e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 83.31 E-value: 3.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1221 KIQLFSGPDFLGDHISFEDDQTSLPVSF---QPQSCRVHGGSWILFGEKNFEGDQYILSEGEFPTLTAMGCLSSTVlGSL 1297
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGfnsRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 1952703796 1298 QKV 1300
Cdd:pfam00030 80 RPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
851-930 |
6.13e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.54 E-value: 6.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 851 KMILFSEPGCQGSSREVWEDTADTSSW---PRVASVRVVRGCWVLYEEPEFRGRKLVVPEGDV----DLGAPGPAwstqg 923
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERgfnSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYpdwsDWGAPNDR----- 75
|
....*..
gi 1952703796 924 IGSVRRV 930
Cdd:pfam00030 76 IGSLRPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1309-1388 |
2.22e-16 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 75.24 E-value: 2.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1309 IFLYGLECFEGKEIELDREVRSLQAEGFNNHVLSLRIKGGVWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1387
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81
|
.
gi 1952703796 1388 I 1388
Cdd:smart00247 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1128-1208 |
3.30e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 72.16 E-value: 3.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1128 LVLFEATDFEGHAAEVREALPDVELARHGPHTQAIHVLSGVWVAYQKVGFSGEQYVLEKGVYRTCDDWGAGNSALASLQP 1207
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 1952703796 1208 V 1208
Cdd:smart00247 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
851-930 |
6.53e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.39 E-value: 6.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 851 KMILFSEPGCQGSSREVWEDTA---DTSSWPRVASVRVVRGCWVLYEEPEFRGRKLVVPEGDV----DLGAPGPAwstqg 923
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPslqDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYpdyqEWGGFNDQ----- 75
|
....*..
gi 1952703796 924 IGSVRRV 930
Cdd:smart00247 76 ISSIRRI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1221-1297 |
3.43e-14 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 69.07 E-value: 3.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1221 KIQLFSGPDFLGDHISFEDDQTSLPVSF---QPQSCRVHGGSWILFGEKNFEGDQYILSEGEFPTLTAMGCLSSTVlGSL 1297
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQDYGsrdNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
111-450 |
7.66e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.19 E-value: 7.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 111 RRKEAVDQGDSSPQEPRTEQANPEALARTELLVPLPGPREPSPHPgVSLSSGSPRSLEERRVTRTVQTTVVVgghverRV 190
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP-HALVSATPLPPGPAAARQASPALPAA------PA 2740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 191 NSSVTVGPGPWGEAQPRGRNVVRAVRAVVVSPQAE-GSPTRSQARELLSSLVP-TERSPAASRLPRPTAVVPRNPGLGGP 268
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaAGPPRRLTRPAVASLSEsRESLPSPWDPADPPAAVLAPAAALPP 2820
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 269 GGAASGQLPEPGMAEPKDRS-ALGPAGSSE--DGHPPPNQDVPAAHPEQDQSRAPEVLTRKGASGPTQPSPQISRSHVSL 345
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPpPPGPPPPSLplGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 346 PS-SLGRQTPTPSLDPEHPPEQPAVPTYPRTQLTLKPRV-PQALPSIKREGLTDPSVVTSPPMAKSEVlvtgPGQSLAPs 423
Cdd:PHA03247 2901 PPdQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPWLGALV----PGRVAVP- 2975
|
330 340
....*....|....*....|....*..
gi 1952703796 424 stRRKAVPSSGALSAPSSPGNKLVRDS 450
Cdd:PHA03247 2976 --RFRVPQPAPSREAPASSTPPLTGHS 3000
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
939-1019 |
1.84e-09 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 55.59 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 939 IIVYSEKGLKGEQVELTDALEDTQGLEKPLQAASATVSAGLWLLYPKPSFEDSPCILEPGEYPTLEAWGTSDLRVGSLKP 1018
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 1952703796 1019 M 1019
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
277-831 |
3.52e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.80 E-value: 3.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 277 PEPGMAEPKDrsalgPAGSSEDGHPPPN--QDVPAAHPEQDQS----RAPEVLTRKGASGPTQPSPQISRshvslPSSLG 350
Cdd:PHA03247 2496 PDPGGGGPPD-----PDAPPAPSRLAPAilPDEPVGEPVHPRMltwiRGLEELASDDAGDPPPPLPPAAP-----PAAPD 2565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 351 RQTPTPSLDPEhpPEQPAVPTYPRtqltlKPRVP--QALPSIKReGLTDPSVVTSPPmaksevlvtgpgqSLAPSSTRRK 428
Cdd:PHA03247 2566 RSVPPPRPAPR--PSEPAVTSRAR-----RPDAPpqSARPRAPV-DDRGDPRGPAPP-------------SPLPPDTHAP 2624
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 429 AVPSSGALSAPSSPGnklvrdsehvpvfsltqaevvaGPAAPAASSPKPSKVVQAPaGSPSTPKEAVHVTKGDLASCPSQ 508
Cdd:PHA03247 2625 DPPPPSPSPAANEPD----------------------PHPPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQ 2681
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 509 D-------EAVEGLTTFTIPSPQEEE-------IVEGSKVSPIASPTQKELVQDPGAPAAPFSTQTVI--AQDTAVPPAP 572
Cdd:PHA03247 2682 RprrraarPTVGSLTSLADPPPPPPTpepaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpGGPARPARPP 2761
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 573 SSEGKVSPSP-----GGPPASVLIRAEASLesqlvpnSTEGEMLPETSREEEEVALAADMEMFLDTLRSMEPPEILRTHR 647
Cdd:PHA03247 2762 TTAGPPAPAPpaapaAGPPRRLTRPAVASL-------SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 648 LPRAPRSSYLAMYATLPAIEEDQPGPWVLGPSPQEVPTLEGKEEEEEEEEEPENPYLSddeklqrRQEKAGPSPSWDSRP 727
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVS-------RSTESFALPPDQPER 2907
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 728 ARPPQVSCSPLEMMKKHVADAKGPHPELGPEWQASSRPTsrlggsllfsglvsaTQEAPISEPLGTKLSALPPHVTPGTR 807
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT---------------TDPAGAGEPSGAVPQPWLGALVPGRV 2972
|
570 580
....*....|....*....|....
gi 1952703796 808 KVPGQlpLLCSERPPPEKPACAQP 831
Cdd:PHA03247 2973 AVPRF--RVPQPAPSREAPASSTP 2994
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
117-612 |
3.92e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.41 E-value: 3.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 117 DQGDSSPQEPrteQANPEALARTELLVPLPGPREPSP-------HPGVSLSSGSPRSleerrvtrtvqttvvvggHVERR 189
Cdd:PHA03247 2547 DAGDPPPPLP---PAAPPAAPDRSVPPPRPAPRPSEPavtsrarRPDAPPQSARPRA------------------PVDDR 2605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 190 VNSSVTVGPGPWGEAQPRGRnvvravravvvSPQAEGSPTRSQARELLSSLVPTERSPaaSRLPRPTAVVPRNPGLGGPG 269
Cdd:PHA03247 2606 GDPRGPAPPSPLPPDTHAPD-----------PPPPSPSPAANEPDPHPPPTVPPPERP--RDDPAPGRVSRPRRARRLGR 2672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 270 GAASGQLPEpGMAEPKDRSALGPAGSSEDGHPPPNQDVPAAHPEQDQSRAPEVLTRKGASGPTQPSPQISRSHVSLPSSL 349
Cdd:PHA03247 2673 AAQASSPPQ-RPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 350 GRQTPTPSldpehpPEQPAVPTYPRTqltlkPRVPQALPSikrEGLTDPSVVTSPPMAKSEVLVTGPGQSLAPSSTRRKA 429
Cdd:PHA03247 2752 GGPARPAR------PPTTAGPPAPAP-----PAAPAAGPP---RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 430 VPSSGALSAPSSPgnklvrdsehvpvfsltqaevvagpaapaasspkPSKVVQAPAGSPSTPKEAVHVTKGDLAscPSQD 509
Cdd:PHA03247 2818 LPPAASPAGPLPP----------------------------------PTSAQPTAPPPPPGPPPPSLPLGGSVA--PGGD 2861
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 510 EAVEGLTTFTIPSPQEEEIVEGSKVS-PIASPTQKELVQDPGAPAAP----FSTQTVIAQDTAVPPAPSSEGKVSPSPGG 584
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPpqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQP 2941
|
490 500
....*....|....*....|....*...
gi 1952703796 585 PPASVLIRAEASLESQLVPNSTEGEMLP 612
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVP 2969
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
103-582 |
6.02e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 6.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 103 PKEKRPVGRRKEAVDQGDSSPQEPRTEQANPEALARTELLVPLPgPREPSPHPgvSLSSGSPRSLEERRVTRTVQTTVVV 182
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP-PDTHAPDP--PPPSPSPAANEPDPHPPPTVPPPER 2651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 183 GGHverrvnssvtvGPGPwGEAQPRGRNVVRAVRAVVVSPQAegSPTRSQARELLSSLVPTERSPAASRLP--RPTAVVP 260
Cdd:PHA03247 2652 PRD-----------DPAP-GRVSRPRRARRLGRAAQASSPPQ--RPRRRAARPTVGSLTSLADPPPPPPTPepAPHALVS 2717
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 261 RNPGLGGPGGAASGQLPEPG--MAEPKDRSALGPAGSSEDGHPPPNQDVPAAHPEQDQSRAPEvltrkgasgPTQPSPQI 338
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAapAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP---------RRLTRPAV 2788
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 339 SRSHVSLPSSLGRQTPTPSLDPEHPPeQPAVPTYPRTQLTLKPrVPQALPSikregltdPSVVTSPPMAKSEvlvtGPGQ 418
Cdd:PHA03247 2789 ASLSESRESLPSPWDPADPPAAVLAP-AAALPPAASPAGPLPP-PTSAQPT--------APPPPPGPPPPSL----PLGG 2854
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 419 SLAPSSTRRKAVPSSGALSAPSSPgnklvrdsEHVPVFSLTQAEVvagpaapaasSPKPSKVVQAPAGSPSTPKEavhvt 498
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAP--------ARPPVRRLARPAV----------SRSTESFALPPDQPERPPQP----- 2911
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 499 kgdlascPSQDEAVEGLTTFTIPSPQEEEIVEGSKVSPIASPTQKELVQDPGAPAAPFSTQTVIAQDTAVP------PAP 572
Cdd:PHA03247 2912 -------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqPAP 2984
|
490
....*....|
gi 1952703796 573 SSEGKVSPSP 582
Cdd:PHA03247 2985 SREAPASSTP 2994
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
238-584 |
5.99e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 54.54 E-value: 5.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 238 SSLVPTERSPAASRLPRPTAVVPRNPGLGGPGGAASGQLPEPGM----AEPKDRSALGPAGSSEDGHPPPNQDVPAAHPE 313
Cdd:pfam05109 451 STHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngTESKAPDMTSPTSAVTTPTPNATSPTPAVTTP 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 314 QDQSRAPEVLTRKGASGPTQPSPQISRSHVSLPSSLGRQTpTPSLDPEHPPEQPAVPTYPRTQLTLKPRVPQALPSIKRE 393
Cdd:pfam05109 531 TPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNAT-IPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTL 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 394 GLTDPS-VVTSPPMAKSEVLVTGPGQSLAPSSTRRKAVPSSGALS-APSSPGNKlvrdSEHVPVfsLTQAEVVAGpaapa 471
Cdd:pfam05109 610 GGTSSTpVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETlSPSTSDNS----TSHMPL--LTSAHPTGG----- 678
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 472 asspkpSKVVQAPAGSPSTPkeavHVTKGDLASCPSQDEAVEGL-TTFTIPSPQEEEIVEGSKVSPIASPTqkelvqdpg 550
Cdd:pfam05109 679 ------ENITQVTPASTSTH----HVSTSSPAPRPGTTSQASGPgNSSTSTKPGEVNVTKGTPPKNATSPQ--------- 739
|
330 340 350
....*....|....*....|....*....|....
gi 1952703796 551 APAapfstqtviAQDTAVPPAPSSEGKVSPSPGG 584
Cdd:pfam05109 740 APS---------GQKTAVPTVTSTGGKANSTTGG 764
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
202-607 |
3.04e-06 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 51.88 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 202 GEAQPRGRNVVRAVRAVVVSPQAEGSPTRSQ---ARELLSSLVPTERSPAASRLPRPTAvvprnpGLGGPGGAASGQLPE 278
Cdd:pfam17823 44 GDAVPRADNKSSEQ*NFCAATAAPAPVTLTKgtsAAHLNSTEVTAEHTPHGTDLSEPAT------REGAADGAASRALAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 279 PGMAEPKDRSALGPAGSS---EDGHPPPNQDVPAAhPEQDQSRAPEVLTRKGASGPTQPSPQISRSHVSLPSSLGRQTPT 355
Cdd:pfam17823 118 AASSSPSSAAQSLPAAIAalpSEAFSAPRAAACRA-NASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 356 PSLDPEHPPEQPAVPTYPRTQLTLKPRVPQALPSIkregltdPSVVTSPPMAKSEVLVTGPGqSLAPSSTRRKAVPSSGA 435
Cdd:pfam17823 197 TAASSAPATLTPARGISTAATATGHPAAGTALAAV-------GNSSPAAGTVTAAVGTVTPA-ALATLAAAAGTVASAAG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 436 LSAPSSPGNKLVRDSEHVPvfSLTQAEVVAGPAAPAASSPKPSKVVQAP----AGSPSTPKEAVHVTKGDLASCPSQDEA 511
Cdd:pfam17823 269 TINMGDPHARRLSPAKHMP--SDTMARNPAAPMGAQAQGPIIQVSTDQPvhntAGEPTPSPSNTTLEPNTPKSVASTNLA 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 512 VEGLTTF--------TIPSPQEEEIVEGSKVSPIASPTQKELVQDPGAPAAPFSTQTVIAQDTavpPAPSSEGKVSPSPG 583
Cdd:pfam17823 347 VVTTTKAqakepsasPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVATEAT---AGTASAGPTPRSSG 423
|
410 420
....*....|....*....|....
gi 1952703796 584 GPPASVLIRAEASLESQLVPNSTE 607
Cdd:pfam17823 424 DPKTLAMASCQLSTQGQYLVVTTD 447
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
324-619 |
1.08e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 324 TRKG-ASGPTQPSPQISRShvSLPSSLGRQTPTPSLDPehPPEQPAVPT--YPRTQLTLKPRVPQALPSIKREGLTDPSV 400
Cdd:pfam17823 102 TREGaADGAASRALAAAAS--SSPSSAAQSLPAAIAAL--PSEAFSAPRaaACRANASAAPRAAIAAASAPHAASPAPRT 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 401 VTSPPMAKSEVLVTGPGQSLAPSSTRRKAVPSSGALSAPSSPGNklvrdsehvPVFSLTQAEVVAGPAAPAASSPKPSKV 480
Cdd:pfam17823 178 AASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGH---------PAAGTALAAVGNSSPAAGTVTAAVGTV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 481 VQAPAGSPSTPKEAVHVTKGdlascpsqdeavegltTFTIPSPQeeeiveGSKVSPIASPTQKELVQDPGAPAAPfSTQT 560
Cdd:pfam17823 249 TPAALATLAAAAGTVASAAG----------------TINMGDPH------ARRLSPAKHMPSDTMARNPAAPMGA-QAQG 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952703796 561 VIAQDTAVPPAPSSEGKVSPSPGGPPASVLIRAEASLESQLVPNSTEGEM---------LPETSREEE 619
Cdd:pfam17823 306 PIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAkepsaspvpVLHTSMIPE 373
|
|
| beta-trefoil_Ricin_SCDase |
cd23456 |
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide ... |
1394-1512 |
2.47e-05 |
|
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467334 [Multi-domain] Cd Length: 122 Bit Score: 45.04 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1394 YFRLWNAALRGFLAVPDHVedMKAGRVVVSEPQAGGSCIWYYE-DGLLKNQVI--------GPPSPGSKAVLWAESRLPR 1464
Cdd:cd23456 2 YFQLKSQASGLCLDVSGGA--TNGANVVVYDCNNSNSQKWYYDaTGRLHSKANpgkcldagGENSNGANVVLWACNDSAN 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1952703796 1465 QTWSIsESGHICSQMFEGRILDVKGGRGydrDHVVLWEPTKDrASQLW 1512
Cdd:cd23456 80 QRWDF-DGNFIRSRNNTNLALDAYGSQG---SNVGLWQFHGG-ANQQW 122
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
221-637 |
3.29e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.83 E-value: 3.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 221 SPQAEGSPTRSQARELLSSLVPTERSPAASRLPRPTAVvprnpglggpggaasgqlPEPGMAEPKDRSAlGPAGSSEDGH 300
Cdd:PRK07764 368 SDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAA------------------PAAAPAPAAAAPA-AAAAPAPAAA 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 301 PPPNQDVPAAHPEQDQSRAPEVL----TRKGASGPTQPSPQISRSHVSLPSSLGRQTPTPSldPEHPPEQPAVPTYPRTQ 376
Cdd:PRK07764 429 PQPAPAPAPAPAPPSPAGNAPAGgapsPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPA--PAAAPAAPAAPAAPAGA 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 377 LTLK------PRVPQALPSIKR------------EGLTDPSVV---TSPPMAK-------SEVLVT-------------- 414
Cdd:PRK07764 507 DDAAtlrerwPEILAAVPKRSRktwaillpeatvLGVRGDTLVlgfSTGGLARrfaspgnAEVLVTalaeelggdwqvea 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 415 ---GPGQSLAPSSTRRKAVPSSG-ALSAPSSPGNKLVRDSEHVPVFSLTQAEVVAGPAAPAASSPKPSKVVQAPAGSPST 490
Cdd:PRK07764 587 vvgPAPGAAGGEGPPAPASSGPPeEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 491 PKEAVHVTKGDLASCPSQDEAVEGLTTFTIPSPQEeeiVEGSKVSPIASPTQKELVQDPGAPAAPFSTQTVIAQDTAVPP 570
Cdd:PRK07764 667 DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQP---APAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP 743
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952703796 571 APSSEGKVSPSPGGPPA--SVLIRAEASLESQLVPNSTEGEMLPETSREEEEVALAADMEMFLDTLRSM 637
Cdd:PRK07764 744 EPDDPPDPAGAPAQPPPppAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEE 812
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
281-588 |
1.31e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.70 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 281 MAEPKDRSALGPAGSseDGHPPPNQDVPAAHPEQDQSRAPEVLTRKGASGPTQPSPQISRSHVSLPSSlgrqtPTPSLDP 360
Cdd:PHA03307 60 AACDRFEPPTGPPPG--PGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS-----PPPSPAP 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 361 EHPPEQPAVPTYPRTQLTL-------KPRVPQALPSIKREGL---TDPSVVTSPPMAKSEVLVTGPGQSLAPSSTRRKAV 430
Cdd:PHA03307 133 DLSEMLRPVGSPGPPPAASppaagasPAAVASDAASSRQAALplsSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 431 PSSGALSAPSSPGNKLVRDSEHVPVFSLTQAEVVAGPAAPAASSPKPSKVVQAP----AGSPSTPKEAVHVTK----GDL 502
Cdd:PHA03307 213 ISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtriwEASGWNGPSSRPGPAssssSPR 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 503 ASCPSQDEAVEGLTTFTIPSPQEEEIVEGSKVSPIASPTQKELVQDPGAPAAPFSTQTVIAQDTAVPPAPSSEGKVSPSP 582
Cdd:PHA03307 293 ERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372
|
....*.
gi 1952703796 583 GGPPAS 588
Cdd:PHA03307 373 RAPSSP 378
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
277-730 |
3.69e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 45.45 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 277 PEPGMAEPKdrsalGPA-GSSEDGHPPPNQ--DVPAAHPEQDQSRAPEVLTRKGASGPTQPS--PQISRShvslpsslgr 351
Cdd:PTZ00449 514 PEASGLPPK-----APGdKEGEEGEHEDSKesDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiPTLSKK---------- 578
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 352 qtPTPSLDPEHP--PEQPAVPTYPRTqltlkPRVPQALPSIKREGLTDpsVVTSPPMAKSEVLVTGPGQSLAPSSTRRKA 429
Cdd:PTZ00449 579 --PEFPKDPKHPkdPEEPKKPKRPRS-----AQRPTRPKSPKLPELLD--IPKSPKRPESPKSPKRPPPPQRPSSPERPE 649
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 430 VPSSgaLSAPSSPgnklvrDSEHVPVFSLTQAEVVAGPAAPAASSPKPSKVVQAPAGSPSTPKEAVHVTKGDLASCPSqd 509
Cdd:PTZ00449 650 GPKI--IKSPKPP------KSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPR-- 719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 510 eaveglttftiPSPQEEEIVEGSKVSPIASPTQkELVQDPGAPAAPFSTQTVIAQDTAVPPAPSSEGKVSPSPG-----G 584
Cdd:PTZ00449 720 -----------PLPPKLPRDEEFPFEPIGDPDA-EQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDihaetG 787
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 585 PPASVLIRAEASLESQLVPNSTEGEMlPETSREEEEVALAA-DMEMfldtlrsmEPPEILR--THRLPRAPRSSYLAMYA 661
Cdd:PTZ00449 788 EPDEAMKRPDSPSEHEDKPPGDHPSL-PKKRHRLDGLALSTtDLES--------DAGRIAKdaSGKIVKLKRSKSFDDLT 858
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952703796 662 TLPAIEEDQPgpwvlgPSPQEVPTLEGKEEEEEEEEEPENPYLSddEKLQRRQEKAGPSPSWDSRPARP 730
Cdd:PTZ00449 859 TVEEAEEMGA------EARKIVVDDDGTEADDEDTHPPEEKHKS--EVRRRRPPKKPSKPKKPSKPKKP 919
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
521-835 |
4.86e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 4.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 521 PSPQEEEIVEGSKVSPIAS-PTQKELVQDPGAPAAPFSTQTVIAQ--DTAVPPAPSSEGKVSPSPGGPPASVliRAEASL 597
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSePAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 598 ESQLVPNSTEGEMLPETSREEEEVALAADMEMFLDTLRSMEPPEILRTHRLPraPRSSYLAMYATLPAIE---EDQPGPW 674
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADPPPPPptpEPAPHAL 2715
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 675 VLGPSPQEVPTLEGKEEEEEEEEEPENPylsddeklqrrqEKAGP-SPSWDSRPARPPQVSCSPlemmkkhvADAKGPHP 753
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPA------------VPAGPaTPGGPARPARPPTTAGPP--------APAPPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 754 ELGPEWQASSRPTSRLGGSLlfSGLVSATQEAPISEPLGTKLSALPPHVTPGTRKVPGQLPLLCSERPPPEKPACAQPLA 833
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESR--ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
|
..
gi 1952703796 834 GW 835
Cdd:PHA03247 2854 GS 2855
|
|
| beta-trefoil_Ricin-like |
cd00161 |
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ... |
1394-1512 |
6.07e-04 |
|
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.
Pssm-ID: 467293 [Multi-domain] Cd Length: 134 Bit Score: 41.59 E-value: 6.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1394 YFRLWNAALRGFLAVPDHveDMKAGRVVVSEPQAGGSC-IWYYED-----GLLKNQVIG--------PPSPGSKAVLWAE 1459
Cdd:cd00161 2 TYRIVNAASGKCLDVAGG--STANGAPVQQWTCNGGANqQWTLTPvgdgyYTIRNVASGkcldvaggSTANGANVQQWTC 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1952703796 1460 SRLPRQTWSISESG----HICSQMfEGRILDVKGGRGYDRDHVVLWEPTkDRASQLW 1512
Cdd:cd00161 80 NGGDNQQWRLEPVGdgyyRIVNKH-SGKCLDVSGGSTANGANVQQWTCN-GGANQQW 134
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
187-442 |
6.64e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.39 E-value: 6.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 187 ERRVNSSVTVGPGPWGEAQPRGRNVVRAVRAVVVSPQAEGSPTRSQArellsslvPTERSPAASRLPRPTAVVPRNPGLG 266
Cdd:PHA03307 81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPP--------PSPAPDLSEMLRPVGSPGPPPAASP 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 267 GPGGAASGQLPEPGMAEPKDRSALGPAGSSEDGHPPPNQDVPAAHPEQDQSRAPEVLTRKGASGPTQPSPQISRS-HVSL 345
Cdd:PHA03307 153 PAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSaADDA 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 346 PSSLGRQTPTPSLD---------PEHPPEQPAVPTYPRTQLTLKPRVPQALPSIKREGLTDPSVVTSPPMAKSEVLVTGP 416
Cdd:PHA03307 233 GASSSDSSSSESSGcgwgpenecPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSP 312
|
250 260
....*....|....*....|....*.
gi 1952703796 417 GQSLAPSSTRRKAVPSSGALSAPSSP 442
Cdd:PHA03307 313 RASSSSSSSRESSSSSTSSSSESSRG 338
|
|
| Ricin_B_lectin |
pfam00652 |
Ricin-type beta-trefoil lectin domain; |
1433-1512 |
8.85e-04 |
|
Ricin-type beta-trefoil lectin domain;
Pssm-ID: 395527 [Multi-domain] Cd Length: 126 Bit Score: 40.98 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1433 W-YYEDGLLKNQV------IGPPSPGSKAVLWA-ESRLPRQTWSISESGHICSQMFEGRILDVKGGrGYDRDHVVLWEPT 1504
Cdd:pfam00652 40 WtLTGDGTIRSVAsdlcldVGSTADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWTCD 118
|
....*...
gi 1952703796 1505 KDRASQLW 1512
Cdd:pfam00652 119 SGNPNQQW 126
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
123-405 |
9.36e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 9.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 123 PQEPRTEQANPEALARTELLVPLPgprePSPHPgvsLSSGsPRSLEERRVTRTVQTTVVVGghverrvNSSVTVGPGPWG 202
Cdd:pfam03154 253 TQPPPPSQVSPQPLPQPSLHGQMP----PMPHS---LQTG-PSHMQHPVPPQPFPLTPQSS-------QSQVPPGPSPAA 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 203 EAQPRGRNVVRAVRAVVVSPQaegsPTRSQARELLSSLVPTERSPAA---SRLPRPTAVVPRNPGLGGPGGAASGQLPEP 279
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQ----PPREQPLPPAPLSMPHIKPPPTtpiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPP 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 280 GMAEPkdRSALgPAGSSEDGHPPPNQDVPAAHPEQDQSRAPEVLTRK------GASGPTQ----------PSPQISRSHV 343
Cdd:pfam03154 394 PALKP--LSSL-STHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSqslpppAASHPPTsglhqvpsqsPFPQHPFVPG 470
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1952703796 344 SLPSSLGRQTPTPSLDPEHPPEQPAVPTYPRTQLTLKPRVPQALPS--IKREGLTDPSVVTSPP 405
Cdd:pfam03154 471 GPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPvqIKEEALDEAEEPESPP 534
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
103-441 |
1.01e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.16 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 103 PKEKRPVGRRKEAVDQGDSSPQEPRTEQANPEALARTELLVPLPGPREPSPHPGVSLSSGSPRSLEERRVTRTVQTTVVV 182
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 183 GGHVERRVNSSVTVgPGPWGEAQPRGRNVVRAVRAVVVSPQAEgsPTRSQARellsslvptERSPAASRLPRPTAVVPrn 262
Cdd:PHA03247 2859 GGDVRRRPPSRSPA-AKPAAPARPPVRRLARPAVSRSTESFAL--PPDQPER---------PPQPQAPPPPQPQPQPP-- 2924
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 263 pglggPGGAASGQLPEPGMAEPKDRSALGPAGSSEDGHPPPNQDVPAAHPeqdqSRAPEVLTRKGASGPTQPSPQISRSH 342
Cdd:PHA03247 2925 -----PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP----GRVAVPRFRVPQPAPSREAPASSTPP 2995
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 343 VSLPSSLGRQTPTPSL----DPEHPPEQPAVPTYPrtqltlkprvpqalPSIKREGLTDPSVVTSPPMAKSEVLVTGPGQ 418
Cdd:PHA03247 2996 LTGHSLSRVSSWASSLalheETDPPPVSLKQTLWP--------------PDDTEDSDADSLFDSDSERSDLEALDPLPPE 3061
|
330 340
....*....|....*....|....
gi 1952703796 419 SLAPSSTR-RKAVPSSGALSAPSS 441
Cdd:PHA03247 3062 PHDPFAHEpDPATPEAGARESPSS 3085
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|
| beta-trefoil_Ricin_XLN-like |
cd23418 |
ricin B-type lectin domain, beta-trefoil fold, found in Streptomyces olivaceoviridis endo-1, ... |
1446-1542 |
1.59e-03 |
|
ricin B-type lectin domain, beta-trefoil fold, found in Streptomyces olivaceoviridis endo-1,4-beta-xylanase and similar proteins; The family includes Streptomyces olivaceoviridis endo-1,4-beta-xylanase (XLN, EC 3.2.1.8), Streptomyces avermitilis beta-L-arabinopyranosidase (EC 3.2.1.185), and Streptomyces coelicolor extracellular exo-alpha-L-arabinofuranosidase (ABF, EC 3.2.1.55). XLN, also called xylanase, or 1,4-beta-D-xylan xylanohydrolase, belongs to the glycosyl hydrolase 10 (cellulase F) family. It contributes to hydrolyze hemicellulose, the major component of plant cell walls. XLN contains a (beta/alpha)8-barrel as a catalytic domain, a family 13 carbohydrate binding module (CBM13) as a xylan binding domain (XBD) and a Gly/Pro-rich linker between them. Beta-L-arabinopyranosidase belongs to the glycosyl hydrolase 27 (GH27) family. It has a GH27 catalytic domain, an antiparallel beta-domain containing Greek key motifs, another antiparallel beta-domain forming a jellyroll structure, and a CBM13 module. ScAraf62A, also called ABF, or arabinosidase, or arabinoxylan arabinofuranohydrolase, belongs to the glycosyl hydrolase 62 (GH62) family. It is involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. It acts synergistically with xylanases and binds specifically to xylan. ScAraf62A comprises a CBM13 module at its N-terminus and a catalytic domain at its C-terminus. This model corresponds to the CBM13 module, which is a ricin B-type lectin domain with a beta-trefoil fold, characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may contain a potential sugar-binding pocket.
Pssm-ID: 467297 [Multi-domain] Cd Length: 130 Bit Score: 40.41 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1446 GPPSPGSKAVLWAESRLPRQTWSISESGHIcsQMFEGRILDVKGGRGYDRDHVVLWEPTKDrASQLWFWGSD---VRPPS 1522
Cdd:cd23418 22 GSTTNGTRLILWDCHGGANQQFTFTSAGEL--RVGGDKCLDAAGGGTTNGTPVVIWPCNGG-ANQKWRFNSDgtiRNVNS 98
|
90 100
....*....|....*....|....*
gi 1952703796 1523 -----ATRGGPGPRLRVSMFSqcCH 1542
Cdd:cd23418 99 glcldVAGGGTANGTRLILWS--CN 121
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|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
276-449 |
2.34e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 42.74 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 276 LPEPGMAEPKDRSALGPAGSSEDGHPPPNQDVpAAHPEQDQSRAPEVLTRKGASGPTQPSPqiSRSHVSLPSSLGRQTPT 355
Cdd:PHA03379 420 VEKPRPEVPQSLETATSHGSAQVPEPPPVHDL-EPGPLHDQHSMAPCPVAQLPPGPLQDLE--PGDQLPGVVQDGRPACA 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 356 PSLDPEHP---PEQPAVPTYPRTqlTLKPRVPQALPSikrEGLTDPSVVTSPPM--AKSEVLVTGPGQSLAPSSTRRKAV 430
Cdd:PHA03379 497 PVPAPAGPivrPWEASLSQVPGV--AFAPVMPQPMPV---EPVPVPTVALERPVcpAPPLIAMQGPGETSGIVRVRERWR 571
|
170
....*....|....*....
gi 1952703796 431 PSSGALSAPSSPGNKLVRD 449
Cdd:PHA03379 572 PAPWTPNPPRSPSQMSVRD 590
|
|
| beta-trefoil_Ricin_GllA-1 |
cd23454 |
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ... |
1430-1513 |
4.52e-03 |
|
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.
Pssm-ID: 467332 [Multi-domain] Cd Length: 136 Bit Score: 39.22 E-value: 4.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952703796 1430 SCIWYYEDGLLKN----QVI----GPPSPGSKAVLWAESRLPR---QTWSISESGHICSQMFEGRILDVKGGRGYDRDHV 1498
Cdd:cd23454 39 SQLWRYDDGYLVNkasgLVLdiqgGVVKSGTRLVQSPKKPSKDannQRWGLTADGYIYLLSNPSLVLGIKGNETREGARV 118
|
90
....*....|....*..
gi 1952703796 1499 VLWE--PTKDRASQLWF 1513
Cdd:cd23454 119 ILQErkLQKDALNQRWT 135
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