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Conserved domains on  [gi|1949432165|ref|XP_038162771|]
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ankyrin repeat and SOCS box protein 7 isoform X2 [Cyprinodon tularosa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-263 5.74e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.01  E-value: 5.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  21 GNPDLHEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHY 100
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 101 AAMHGRARIARLMLEseyRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVR 180
Cdd:COG0666    94 AARNGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 181 ILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTRN 257
Cdd:COG0666   171 LLLEAGADVNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                  ....*.
gi 1949432165 258 YEGQTP 263
Cdd:COG0666   250 KDGLTA 255
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 286-329 4.50e-23

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239696  Cd Length: 45  Bit Score: 89.91  E-value: 4.50e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHKFD 329
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFD 44
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-263 5.74e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.01  E-value: 5.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  21 GNPDLHEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHY 100
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 101 AAMHGRARIARLMLEseyRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVR 180
Cdd:COG0666    94 AARNGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 181 ILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTRN 257
Cdd:COG0666   171 LLLEAGADVNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                  ....*.
gi 1949432165 258 YEGQTP 263
Cdd:COG0666   250 KDGLTA 255
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 286-329 4.50e-23

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 89.91  E-value: 4.50e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHKFD 329
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFD 44
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-220 3.09e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 93.52  E-value: 3.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  34 AVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKdFIGGFTALHYAAMHGRARIARLM 113
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVK-YPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 114 LES-EYRGDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:PHA02875   88 LDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1949432165 193 NGF---LLRYAVIKGNHSYCRMFLQRGADTN 220
Cdd:PHA02875  165 DCCgctPLIIAMAKGDIAICKMLLDSGANID 195
Ank_2 pfam12796
Ankyrin repeats (3 copies);
98-193 8.90e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 8.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  98 LHYAAMHGRARIARLMLESEYRgdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFrAEVDpLSDKGTTPLQLAIIRERSS 177
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1949432165 178 CVRILLDHSANIDIQN 193
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 287-325 3.75e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.40  E-value: 3.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLK 325
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 289-327 4.00e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 4.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1949432165  289 RSLQDLCRIKIRHCIGlqslkFLEDLPIAKVMKDYLKHK 327
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 62-255 6.80e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.78  E-value: 6.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  62 TLLHFSAAKGKERCVRVFLE-HGADPTVKDFIGGfTALHYAAMHGRARIARLMLEsEYRGDIINAKSND---GWTPLHVA 137
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGE-TALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 138 AHYGRDSFVRLLLEFRAEV--------------DPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYA 200
Cdd:cd22192    97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHIL 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949432165 201 VIKGNHSY-CRMF---LQRGADTNLGRLE-----DGQTPLHLSALRDDVLCAQ--------MLYTYGANTNT 255
Cdd:cd22192   177 VLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpnnQGLTPFKLAAKEGNIVMFQhlvqkrrhIQWTYGPLTST 248
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 129-157 4.86e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.86e-04
                           10        20
                   ....*....|....*....|....*....
gi 1949432165  129 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 157
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 26-119 2.84e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  26 HEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLH-------FSAAKGKERC-----VRVFLEHGADPTVKDFI- 92
Cdd:TIGR00870 174 HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmeneFKAEYEELSCqmynfALSLLDKLRDSKELEVIl 253

                          90       100
                  ....*....|....*....|....*....
gi 1949432165  93 --GGFTALHYAAMHGRARIARLMLESEYR 119
Cdd:TIGR00870 254 nhQGLTPLKLAAKEGRIVLFRLKLAIKYK 282
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-263 5.74e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.01  E-value: 5.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  21 GNPDLHEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFiGGFTALHY 100
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 101 AAMHGRARIARLMLEseyRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVR 180
Cdd:COG0666    94 AARNGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 181 ILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTRN 257
Cdd:COG0666   171 LLLEAGADVNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                  ....*.
gi 1949432165 258 YEGQTP 263
Cdd:COG0666   250 KDGLTA 255
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-193 3.95e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 3.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  33 AAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARL 112
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 113 MLEseyRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:COG0666   205 LLE---AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                  .
gi 1949432165 193 N 193
Cdd:COG0666   282 L 282
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 286-329 4.50e-23

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 89.91  E-value: 4.50e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHKFD 329
Cdd:cd03726     1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFD 44
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-220 3.09e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 93.52  E-value: 3.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  34 AVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKdFIGGFTALHYAAMHGRARIARLM 113
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVK-YPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 114 LES-EYRGDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:PHA02875   88 LDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1949432165 193 NGF---LLRYAVIKGNHSYCRMFLQRGADTN 220
Cdd:PHA02875  165 DCCgctPLIIAMAKGDIAICKMLLDSGANID 195
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-263 5.07e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.17  E-value: 5.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  89 KDFIGGFTALHYAAMHGRARIARLMLESEYRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQ 168
Cdd:COG0666    13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 169 LAIIRERSSCVRILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQM 245
Cdd:COG0666    93 AAARNGDLEIVKLLLEAGADVNARDKDgetPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIVKL 171

                         170
                  ....*....|....*...
gi 1949432165 246 LYTYGANTNTRNYEGQTP 263
Cdd:COG0666   172 LLEAGADVNARDNDGETP 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
98-193 8.90e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 8.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  98 LHYAAMHGRARIARLMLESEYRgdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFrAEVDpLSDKGTTPLQLAIIRERSS 177
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1949432165 178 CVRILLDHSANIDIQN 193
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 76-268 2.08e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 88.40  E-value: 2.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  76 VRVFLEHGADPTVKDFIGGFTALHYAAMHGRARIARLMLESEYRGDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFRAE 155
Cdd:PHA02878  150 TKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNN---SPLHHAVKHYNKPIVHILLENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 156 VDPLSDKGTTPLQLAIirersscvrilldhsanidiqnGFLLRYAVIKgnhsycrMFLQRGADTNLGRLEDGQTPLHLSA 235
Cdd:PHA02878  227 TDARDKCGNTPLHISV----------------------GYCKDYDILK-------LLLEHGVDVNAKSYILGLTALHSSI 277

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1949432165 236 LRDDVLcaQMLYTYGANTNTRNYEGQTPVAVSV 268
Cdd:PHA02878  278 KSERKL--KLLLEYGADINSLNSYKLTPLSSAV 308
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 42-201 3.48e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 84.63  E-value: 3.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  42 TVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLEseyRGD 121
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKHNFFDIIKLLLE---KGA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 122 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGFL-LRYA 200
Cdd:PHA02874  182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDIDGSTpLHHA 261


                  .
gi 1949432165 201 V 201
Cdd:PHA02874  262 I 262
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-157 1.77e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  64 LHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESEyrgdIINAKsNDGWTPLHVAAHYGRD 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLEHA----DVNLK-DNGRTALHYAARSGHL 74

                          90
                  ....*....|....
gi 1949432165 144 SFVRLLLEFRAEVD 157
Cdd:pfam12796  75 EIVKLLLEKGADIN 88
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-190 3.73e-17

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 3.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  39 DICTVRRMLEQGYSPKIRDANGWTLLHFSA--AKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARiARLMLES 116
Cdd:PHA03095  166 NVELLRLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATD-MLGNTPLHSMATGSSCK-RSLVLPL 243

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1949432165 117 EYRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANID 190
Cdd:PHA03095  244 LIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAE 317
Ank_2 pfam12796
Ankyrin repeats (3 copies);
34-124 1.74e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  34 AVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGAdptVKDFIGGFTALHYAAMHGRARIARLM 113
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 1949432165 114 LESEYRGDIIN 124
Cdd:pfam12796  81 LEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-221 4.67e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 4.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 134 LHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDH-SANIDIQNGFLLRYAVIKGNHSYCRMF 212
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVNLKDNGRTALHYAARSGHLEIVKLL 80


                  ....*....
gi 1949432165 213 LQRGADTNL 221
Cdd:pfam12796  81 LEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 7-255 1.24e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165   7 SLQLVKRMLNHHCRGNP-DLHEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHF-SAAKGKERCVR----VFL 80
Cdd:PHA03100   14 KVKNIKYIIMEDDLNDYsYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlSNIKYNLTDVKeivkLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  81 EHGADPTVKDfIGGFTALHYAAMH--GRARIARLMLEseyRGDIINAKSNDGWTPLHVAAHYGRDSF--VRLLLEFRAEV 156
Cdd:PHA03100   94 EYGANVNAPD-NNGITPLLYAISKksNSYSIVEYLLD---NGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 157 DplsdkgttplqlAIIRersscVRILLDHSANIDIQN--GFL-LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHL 233
Cdd:PHA03100  170 N------------AKNR-----VNYLLSYGVPINIKDvyGFTpLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHI 231

                         250       260
                  ....*....|....*....|..
gi 1949432165 234 SALRDDVLCAQMLYTYGANTNT 255
Cdd:PHA03100  232 AILNNNKEIFKLLLNNGPSIKT 253
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 62-328 1.47e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  62 TLLHFSAAKGKER-CVRVFLEHGADPTVKDFIGgFTALHYAAM------HGRaRIARLMLEseyRGDIINAKSNDGWTPL 134
Cdd:PHA03100   36 VLPLYLAKEARNIdVVKILLDNGADINSSTKNN-STPLHYLSNikynltDVK-EIVKLLLE---YGANVNAPDNNGITPL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 135 HVAAHYGRDSF--VRLLLEFRAEVDPLSDKGTTPLQLAI--IRERSSCVRILLDHSANIDIQNgfllryaVIKgnhsycr 210
Cdd:PHA03100  111 LYAISKKSNSYsiVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKN-------RVN------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 211 MFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTRNYEGQTPVAVSVsmsgisRPC-LDFLQEVTRQPR 289
Cdd:PHA03100  177 YLLSYGVPINI-KDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI------LNNnKEIFKLLLNNGP 249

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1949432165 290 SLQDLCRikirhCIGLQSLKFLEDLPIAKVMKDYLKHKF 328
Cdd:PHA03100  250 SIKTIIE-----TLLYFKDKDLNTITKIKMLKKSIMYMF 283
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 42-197 2.55e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.16  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  42 TVRRMLEQGYSPKIRDANGWTLLHFSAAKGKE--RCVRVFLEHGADPTVKDFIGgFTALHYAAMHGRA--RIARLMLESE 117
Cdd:PHA03100   88 IVKLLLEYGANVNAPDNNGITPLLYAISKKSNsySIVEYLLDNGANVNIKNSDG-ENLLHLYLESNKIdlKILKLLIDKG 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 118 YRGDI-------------INAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLD 184
Cdd:PHA03100  167 VDINAknrvnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246

                         170
                  ....*....|...
gi 1949432165 185 HSANIDIQNGFLL 197
Cdd:PHA03100  247 NGPSIKTIIETLL 259
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-292 3.94e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 73.17  E-value: 3.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  28 ELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHF-SAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHG- 105
Cdd:PHA02876  241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHaSQAPSLSRLVPKLLERGADVNAKN-IKGETPLYLMAKNGy 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 106 -RARIARLMLeseyRGDIINAKSNDGWTPLHVAAHYGRDS-FVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILL 183
Cdd:PHA02876  320 dTENIRTLIM----LGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 184 DHSANIDIQN---GFLLRYAVIKGN-HSYCRMFLQRGADTNlGRLEDGQTPLHLSALRD---DVLcaQMLYTYGANTNTR 256
Cdd:PHA02876  396 DYGADIEALSqkiGTALHFALCGTNpYMSVKTLIDRGANVN-SKNKDLSTPLHYACKKNcklDVI--EMLLDNGADVNAI 472

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1949432165 257 NYEGQTPVAVSVSMSGISRPCLDFLQEVtRQPRSLQ 292
Cdd:PHA02876  473 NIQNQYPLLIALEYHGIVNILLHYGAEL-RDSRVLH 507
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-193 4.07e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  34 AVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLM 113
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACIKLL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 114 LESeyrGDIINAKSNDGWTPLHVAAHYGRdSFVRLLLEfRAEVDPLSDKGTTPLQLAIireRSSC----VRILLDHSANI 189
Cdd:PHA02874  210 IDH---GNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLHHAI---NPPCdidiIDILLYHKADI 281


                  ....
gi 1949432165 190 DIQN 193
Cdd:PHA02874  282 SIKD 285
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-264 4.80e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.36  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  39 DICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERC---VRVFLEHGADPTVKDfIGGFTALHYAAMHG-RARIARLML 114
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPE-RCGFTPLHLYLYNAtTLDVIKLLI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 115 EseyRGDIINAKSNDGWTPLHV-----AAHYGrdsFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSS--CVRILLDHSA 187
Cdd:PHA03095  105 K---AGADVNAKDKVGRTPLHVylsgfNINPK---VIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRLLIDAGA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 188 NI----DIQNGFLLRYAV-IKGNHSYCRMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCAQM--LYTYGANTNTRNYEG 260
Cdd:PHA03095  179 DVyavdDRFRSLLHHHLQsFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYG 257


                  ....
gi 1949432165 261 QTPV 264
Cdd:PHA03095  258 QTPL 261
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 286-327 4.88e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.21  E-value: 4.88e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 287-327 1.11e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.41  E-value: 1.11e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA03095 PHA03095
ankyrin-like protein; Provisional
 29-240 2.32e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.44  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  29 LQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLH-FSAAKGKE-RCVRVFLEHGADPTVKDFIgGFTALHYAAMHGR 106
Cdd:PHA03095  121 LHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvLLKSRNANvELLRLLIDAGADVYAVDDR-FRSLLHHHLQSFK 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 107 ARiARLMLESEYRGDIINAKSNDGWTPLHVAAHYG--RDSFVRLLLEFRAEVDPLSDKGTTPLQlaiirersscvrilld 184
Cdd:PHA03095  200 PR-ARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLH---------------- 262

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1949432165 185 hsanidiqngfllrYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDV 240
Cdd:PHA03095  263 --------------YAAVFNNPRACRRLIALGADINA-VSSDGNTPLSLMVRNNNG 303
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 43-193 1.53e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.98  E-value: 1.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  43 VRRMLEQGYSPKIRDAN-GWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESeyrGD 121
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLEN---GA 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1949432165 122 IINAKSNDGWTPLHVAAHYGRD-SFVRLLLEFRAEVDPLSD-KGTTPLQLAIIRERSscVRILLDHSANIDIQN 193
Cdd:PHA02878  226 STDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LKLLLEYGADINSLN 297
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-193 3.42e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.20  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165   2 TKRSPSLQLVKRMLNHHCR---------------GNPDLHEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHF 66
Cdd:PLN03192  485 TRQEDNVVILKNFLQHHKElhdlnvgdllgdnggEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHI 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  67 SAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESEYRGDiinakSNDGWTPLHVAAHYGRDSFV 146
Cdd:PLN03192  565 AASKGYEDCVLVLLKHACNVHIRD-ANGNTALWNAISAKHHKIFRILYHFASISD-----PHAAGDLLCTAAKRNDLTAM 638

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1949432165 147 RLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQN 193
Cdd:PLN03192  639 KELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 97-274 2.22e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.08  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  97 ALHYAAMHGRARIARLMLESEYRGdiiNAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERS 176
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINP---NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 177 SCVRILLDHSANID---IQNGFL-LRYAVIKGNHSYCRMFLQRGADTNLGRlEDGQTPLHLSALRDDVLCAQMLYTYGAN 252
Cdd:PHA02875   82 KAVEELLDLGKFADdvfYKDGMTpLHLATILKKLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKAC 160

                         170       180
                  ....*....|....*....|..
gi 1949432165 253 TNTRNYEGQTPVAVSVSMSGIS 274
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGDIA 182
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 85-186 2.38e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 2.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  85 DPTVKDFIGgfTALHYAAMHGRARIARLMLESeyrGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGT 164
Cdd:PTZ00322   75 DPVVAHMLT--VELCQLAASGDAVGARILLTG---GADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK 149

                          90       100
                  ....*....|....*....|..
gi 1949432165 165 TPLQLAIIRERSSCVRILLDHS 186
Cdd:PTZ00322  150 TPLELAEENGFREVVQLLSRHS 171
Ank_4 pfam13637
Ankyrin repeats (many copies);
60-114 2.73e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 2.73e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1949432165  60 GWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLML 114
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 287-325 3.75e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.40  E-value: 3.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLK 325
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 108-264 5.74e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 5.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 108 RIARLMLEseyRGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSA 187
Cdd:PHA02876  159 LIAEMLLE---GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 188 NIDiQNGFLLRYAVIKGNHSYCRMFLQRGADTNlgRLEDGQ-TPLHLSALRDDV--LCAQMLyTYGANTNTRNYEGQTPV 264
Cdd:PHA02876  236 NIN-KNDLSLLKAIRNEDLETSLLLYDAGFSVN--SIDDCKnTPLHHASQAPSLsrLVPKLL-ERGADVNAKNIKGETPL 311
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 36-114 6.60e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 6.60e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1949432165  36 AAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARLML 114
Cdd:PTZ00322   91 ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK-TPLELAEENGFREVVQLLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-183 4.87e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 4.87e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1949432165 130 GWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILL 183
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 99-271 9.26e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 9.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  99 HYAAMHGrARIARLMLESEYRGDIINAKSNdgwtpLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSC 178
Cdd:PLN03192  500 HHKELHD-LNVGDLLGDNGGEHDDPNMASN-----LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDC 573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 179 VRILLDHSANI---DIQNGFLLRYAVIKGNHSYCRMFLQrgadtnLGRLEDGQTP---LHLSALRDDVLCAQMLYTYGAN 252
Cdd:PLN03192  574 VLVLLKHACNVhirDANGNTALWNAISAKHHKIFRILYH------FASISDPHAAgdlLCTAAKRNDLTAMKELLKQGLN 647

                         170
                  ....*....|....*....
gi 1949432165 253 TNTRNYEGQTpvAVSVSMS 271
Cdd:PLN03192  648 VDSEDHQGAT--ALQVAMA 664
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 17-252 1.51e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.76  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  17 HHCRGNPDLHEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFT 96
Cdd:PHA02876  135 HYDKINESIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIA-LDDLS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  97 ALHYAA-----------MHGRARIAR------------------LMLESEYRGDIINAKSNdgwTPLHVAAHygRDSFVR 147
Cdd:PHA02876  214 VLECAVdsknidtikaiIDNRSNINKndlsllkairnedletslLLYDAGFSVNSIDDCKN---TPLHHASQ--APSLSR 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 148 L---LLEFRAEVDPLSDKGTTPLQL-AIIRERSSCVRILLDHSANID----IQNGFLLRYAVIKGNHSYCRMFLQRGADT 219
Cdd:PHA02876  289 LvpkLLERGADVNAKNIKGETPLYLmAKNGYDTENIRTLIMLGADVNaadrLYITPLHQASTLDRNKDIVITLLELGANV 368

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1949432165 220 NLGRLEDgQTPLHLSALRDDVLCAQMLYTYGAN 252
Cdd:PHA02876  369 NARDYCD-KTPIHYAAVRNNVVIINTLLDYGAD 400
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 197-327 1.95e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 51.91  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 197 LRYAVIKGNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTRNYEGQTPVAVSvsmsgiSRP 276
Cdd:PHA02884   74 LIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA------LMI 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1949432165 277 CLDFLQEVTRQpRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:PHA02884  148 CNNFLAFMICD-NEISNFYKHPKKILINFDILKILVSHFILQASNDRLNEK 197
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-268 2.63e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 119 RGDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAN---------- 188
Cdd:PHA02874   24 KGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipcie 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 189 -------------IDIQNGFL---LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYTYGAN 252
Cdd:PHA02874  104 kdmiktildcgidVNIKDAELktfLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         170
                  ....*....|....*.
gi 1949432165 253 TNTRNYEGQTPVAVSV 268
Cdd:PHA02874  183 ANVKDNNGESPLHNAA 198
Ank_4 pfam13637
Ankyrin repeats (many copies);
96-150 3.06e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 3.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1949432165  96 TALHYAAMHGRARIARLMLESeyrGDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 150
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK---GADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 289-327 4.00e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 4.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1949432165  289 RSLQDLCRIKIRHCIGlqslkFLEDLPIAKVMKDYLKHK 327
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 62-255 6.80e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.78  E-value: 6.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  62 TLLHFSAAKGKERCVRVFLE-HGADPTVKDFIGGfTALHYAAMHGRARIARLMLEsEYRGDIINAKSND---GWTPLHVA 137
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGE-TALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 138 AHYGRDSFVRLLLEFRAEV--------------DPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYA 200
Cdd:cd22192    97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHIL 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949432165 201 VIKGNHSY-CRMF---LQRGADTNLGRLE-----DGQTPLHLSALRDDVLCAQ--------MLYTYGANTNT 255
Cdd:cd22192   177 VLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpnnQGLTPFKLAAKEGNIVMFQhlvqkrrhIQWTYGPLTST 248
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 287-325 1.09e-06

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 44.51  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSlkfLEDLPIAKVMKDYLK 325
Cdd:cd03717     2 SVRSLQHLCRFVIRQCTRRDL---IDQLPLPRRLKDYLK 37
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-130 1.56e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.80  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  33 AAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYAAMHGRARIARL 112
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL-TALLLAAAAGAALIVKL 270

                          90
                  ....*....|....*...
gi 1949432165 113 MLESEYRGDIINAKSNDG 130
Cdd:COG0666   271 LLLALLLLAAALLDLLTL 288
Ank_5 pfam13857
Ankyrin repeats (many copies);
123-170 2.01e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 2.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1949432165 123 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLA 170
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 286-327 2.29e-06

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 43.82  E-value: 2.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1949432165  286 RQPRSLQDLCRIKIRHCIGLQSLKfleDLPIAKVMKDYLKHK 327
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIK---TLPLPPKLKDYLSYY 43
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 288-327 6.27e-06

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 42.91  E-value: 6.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1949432165 288 PRSLQDLCRIKIRHCIGLQSLK---FLEDLPIAKVMKDYLKHK 327
Cdd:cd03730     3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 163-279 6.85e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 6.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 163 GTTPLQLAIIRERSSCVRILLDHSANIDIQNGFL---LRYAVIKGNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDD 239
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIeseLHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKK 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1949432165 240 VLCAQMLYTYGANTNTRNYEGQTPVAVSVSMSGIS--------RPCLD 279
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKgiellidhKACLD 162
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 113-264 8.22e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 8.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 113 MLESEYRGDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSAnidiq 192
Cdd:PHA02874  110 ILDCGIDVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA----- 181

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949432165 193 ngfllrYAVIKGNHsycrmflqrgadtnlgrledGQTPLHLSALRDDVLCAQMLYTYGANTNTRNYEGQTPV 264
Cdd:PHA02874  182 ------YANVKDNN--------------------GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
PHA02946 PHA02946
ankyin-like protein; Provisional
 43-134 1.67e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 46.20  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  43 VRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDfIGGFTALHYAAMHGRARIARLMLESEYRGDI 122
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACD-KQHKTPLYYLSGTDDEVIERINLLVQYGAKI 133

                          90
                  ....*....|..
gi 1949432165 123 INAKSNDGWTPL 134
Cdd:PHA02946  134 NNSVDEEGCGPL 145
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 287-324 1.90e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 41.13  E-value: 1.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYL 324
Cdd:cd03718     2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYL 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
80-137 2.14e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 2.14e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1949432165  80 LEHGADPTVKDFIGGFTALHYAAMHGRARIARLMLesEYRGDiINAKSNDGWTPLHVA 137
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVD-LNLKDEEGLTALDLA 56
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 288-327 3.45e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 40.62  E-value: 3.45e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1949432165 288 PRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 287-327 4.63e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 40.32  E-value: 4.63e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03743     2 EPLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 288-327 7.51e-05

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 39.82  E-value: 7.51e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1949432165 288 PRSLQDLCRIKIRHCIGLQSLK---FLEDLPIAKVMKDYLKHK 327
Cdd:cd03731     3 PRPLKHLCRLKIRKLMGLQKLQqpsSMKKLPLPPALKRYILYK 45
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 129-157 8.11e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 8.11e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1949432165 129 DGWTPLHVAA-HYGRDSFVRLLLEFRAEVD 157
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 210-268 9.26e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 9.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1949432165 210 RMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTRNYEGQTPVAVSV 268
Cdd:PTZ00322   99 RILLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAE 156
Ank_4 pfam13637
Ankyrin repeats (many copies);
31-80 9.68e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 9.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1949432165  31 IQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFL 80
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 288-327 1.79e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 38.32  E-value: 1.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1949432165 288 PRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 129-157 1.86e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 1.86e-04
                          10        20
                  ....*....|....*....|....*....
gi 1949432165 129 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 157
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_2 pfam12796
Ankyrin repeats (3 copies);
197-281 2.14e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.71  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 197 LRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQMLYTYgANTNTRNYeGQTPVAVSVSMSgiSRP 276
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSG--HLE 75


                  ....*
gi 1949432165 277 CLDFL 281
Cdd:pfam12796  76 IVKLL 80
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-140 2.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  34 AVAAGDICTVRRMLEQGYSPKIRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGFTALHYAAMHGRARIARLM 113
Cdd:PHA02875  142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLF 221

                          90       100
                  ....*....|....*....|....*..
gi 1949432165 114 LESEYRGDIINAKSNDGWTPLHVAAHY 140
Cdd:PHA02875  222 IKRGADCNIMFMIEGEECTILDMICNM 248
Ank_4 pfam13637
Ankyrin repeats (many copies);
163-213 2.69e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 2.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1949432165 163 GTTPLQLAIIRERSSCVRILLDHSANIDIQNGF---LLRYAVIKGNHSYCRMFL 213
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNgetALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1-102 3.28e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165   1 MTKRSPSLQLVKRMLNHHCRGNPD-------LHE------------ELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGW 61
Cdd:PHA03100  114 ISKKSNSYSIVEYLLDNGANVNIKnsdgenlLHLylesnkidlkilKLLIDKGVDINAKNRVNYLLSYGVPINIKDVYGF 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1949432165  62 TLLHFSAAKGKERCVRVFLEHGADPTVKDFIgGFTALHYAA 102
Cdd:PHA03100  194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKY-GDTPLHIAI 233
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-101 3.54e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 3.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1949432165  55 IRDANGWTLLHFSAAKGKERCVRVFLEHGADPTVKDFIGGfTALHYA 101
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL-TALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 59-90 3.72e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 3.72e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1949432165  59 NGWTLLHFSAAK-GKERCVRVFLEHGADPTVKD 90
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 179-269 4.78e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 4.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 179 VRILLDHSANIDIQN----GFLLRYAVIKGNHSYCRMFLQRGADTNLGRLEDgQTPLH--LSALRDDVLcaQMLYTYGAN 252
Cdd:PHA02878  150 TKLLLSYGADINMKDrhkgNTALHYATENKDQRLTELLLSYGANVNIPDKTN-NSPLHhaVKHYNKPIV--HILLENGAS 226

                          90
                  ....*....|....*..
gi 1949432165 253 TNTRNYEGQTPVAVSVS 269
Cdd:PHA02878  227 TDARDKCGNTPLHISVG 243
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 129-157 4.86e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.86e-04
                           10        20
                   ....*....|....*....|....*....
gi 1949432165  129 DGWTPLHVAAHYGRDSFVRLLLEFRAEVD 157
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 287-324 7.43e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 37.03  E-value: 7.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYL 324
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYL 39
PHA03095 PHA03095
ankyrin-like protein; Provisional
 123-281 9.88e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 9.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 123 INAKSNDGWTPLHVAAHYGRD---SFVRLLLEFRAEVDPLSDKGTTPLQLaiirersscvriLLDHSANIDIqngfllry 199
Cdd:PHA03095   40 VNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHL------------YLYNATTLDV-------- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 200 avikgnhsyCRMFLQRGADTNLgRLEDGQTPLH--LSALRDDVLCAQMLYTYGANTNTRNYEGQTPVAVSVSMSGISRPC 277
Cdd:PHA03095  100 ---------IKLLIKAGADVNA-KDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVEL 169


                  ....
gi 1949432165 278 LDFL 281
Cdd:PHA03095  170 LRLL 173
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 162-193 1.30e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1949432165 162 KGTTPLQLAIIRERS-SCVRILLDHSANIDIQN 193
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARD 33
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 132-192 1.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.97  E-value: 1.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949432165 132 TPLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGT-TPLQLAIIRERSSCVRILLDHSANIDIQ 192
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQ 133
Ank_4 pfam13637
Ankyrin repeats (many copies);
196-246 1.84e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1949432165 196 LLRYAVIKGNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCAQML 246
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLL 53
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 288-327 2.05e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 35.53  E-value: 2.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1949432165 288 PRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03729     3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 26-119 2.84e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165  26 HEELQIQAAVAAGDICTVRRMLEQGYSPKIRDANGWTLLH-------FSAAKGKERC-----VRVFLEHGADPTVKDFI- 92
Cdd:TIGR00870 174 HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmeneFKAEYEELSCqmynfALSLLDKLRDSKELEVIl 253

                          90       100
                  ....*....|....*....|....*....
gi 1949432165  93 --GGFTALHYAAMHGRARIARLMLESEYR 119
Cdd:TIGR00870 254 nhQGLTPLKLAAKEGRIVLFRLKLAIKYK 282
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 133-271 3.20e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.09  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 133 PLHVAAHYGRDSFVRLLLEFRAEVDPLSDKGTTPLQLA-----------IIRERSSC-----VRILLD--HSANIDIQNG 194
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIIckepnklgmkeMIRSINKCsvfytLVAIKDafNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949432165 195 FLLRYavIKGNHS------------------YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCAQMLYTYGANTNTR 256
Cdd:PHA02878  120 ILTNR--YKNIQTidlvyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIP 197

                         170
                  ....*....|....*
gi 1949432165 257 NYEGQTPVAVSVSMS 271
Cdd:PHA02878  198 DKTNNSPLHHAVKHY 212
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 286-326 3.85e-03

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 34.70  E-value: 3.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKH 326
Cdd:cd03720     1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
SOCS_SOCS1 cd03735
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the ...
 286-325 4.50e-03

SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. SOCS1 has a dual function as a direct potent JAK kinase inhibitor and as a component of an E3 ubiquitin-ligase complex recruiting substrates to the protein degradation machinery.


Pssm-ID: 239704  Cd Length: 43  Bit Score: 34.51  E-value: 4.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSlkfLEDLPIAKVMKDYLK 325
Cdd:cd03735     1 VRVRPLQELCRKSIVATFGREN---LARIPLNPVLKDYLK 37
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 226-257 4.71e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.19  E-value: 4.71e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1949432165 226 DGQTPLHLSALR-DDVLCAQMLYTYGANTNTRN 257
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 286-327 4.84e-03

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 34.32  E-value: 4.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1949432165 286 RQPRSLQDLCRIKIRHCIGLQSlkfLEDLPIAKVMKDYLKHK 327
Cdd:cd03733     1 RVVSSLQHLCRMALRRVMTTQQ---VLALPIPKKMKEFLTYR 39
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 59-88 5.56e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 5.56e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1949432165   59 NGWTLLHFSAAKGKERCVRVFLEHGADPTV 88
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 94-125 6.90e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 6.90e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1949432165   94 GFTALHYAAMHGRARIARLMLEseyRGDIINA 125
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLD---KGADINA 30
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 287-327 8.09e-03

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 33.84  E-value: 8.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1949432165 287 QPRSLQDLCRIKIRHCIGLQSLKFLEDLPIAKVMKDYLKHK 327
Cdd:cd03719     2 EPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 162-191 9.64e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 9.64e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1949432165  162 KGTTPLQLAIIRERSSCVRILLDHSANIDI 191
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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