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Conserved domains on  [gi|1907171988|ref|XP_036021899|]
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leucine-rich repeat and transmembrane domain-containing protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
92-152 2.65e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 2.65e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907171988  92 SNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSIRTLDRDLLQHSPLLRHLDLSINGL 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 38-67 8.15e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 8.15e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907171988  38 ACPFSCTCdsRSLEVDCSGLGLTTVPPDVP 67
Cdd:pfam01462   1 ACPVPCHC--SATVVNCSDRGLTAVPRDLP 28
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
198-247 5.83e-05

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 5.83e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907171988  198 NPWECDCNLREFKHWLEWFSYRGGRLDqLACTLPKELRGKdMRAVPMEMF 247
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP-LLELLHSEF 48
PHA03264 super family cl42984
envelope glycoprotein D; Provisional
 261-335 2.34e-03

envelope glycoprotein D; Provisional


The actual alignment was detected with superfamily member PHA03264:

Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907171988 261 GLDAPGPPCTKASPEPPK--PKPGAEPEPEPSTACPQKQRYRPVSVrraiGTVIIAGVvcgivcIMMVVAAAYGCIY 335
Cdd:PHA03264  319 GEPKPGPPRPAPDADRPEgwPSLEAITFPPPTPATPAVPRARPVIV----GTGIAAAA------IACVAAAGAVAYF 385
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
92-152 2.65e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 2.65e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907171988  92 SNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSIRTLDRDLLQHSPLLRHLDLSINGL 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-198 2.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  87 AFANLSNLQRLDLSNNFLDQLPRSIfEDLVNLTELQLRNNSIRTLDRDlLQHSPLLRHLDLSINGLAQLPPGLFDgllal 166
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELGN----- 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907171988 167 rslslrSNRLQSLD----RLTFEP-----LASLQLLQVGDN 198
Cdd:COG4886   181 ------LTNLKELDlsnnQITDLPeplgnLTNLEELDLSGN 215
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 38-67 8.15e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 8.15e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907171988  38 ACPFSCTCdsRSLEVDCSGLGLTTVPPDVP 67
Cdd:pfam01462   1 ACPVPCHC--SATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
38-71 9.21e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 9.21e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907171988   38 ACPFSCTCdsRSLEVDCSGLGLTTVPPDVPAATQ 71
Cdd:smart00013   1 ACPAPCNC--SGTAVDCSGRGLTEVPLDLPPDTT 32
LRRCT smart00082
Leucine rich repeat C-terminal domain;
198-247 5.83e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 5.83e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907171988  198 NPWECDCNLREFKHWLEWFSYRGGRLDqLACTLPKELRGKdMRAVPMEMF 247
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP-LLELLHSEF 48
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-198 8.11e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  93 NLQRLDLSNNFLDQLPRsiFEDLVNLTELQLRNNSIRTLDRdlLQHSPLLRHLDLS------INGLA------------- 153
Cdd:cd21340    25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGgnrisvVEGLEnltnleelhienq 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907171988 154 QLPPG---LFDgllaLRSLSLRSNRLQSLD----RLT----FEPLASLQLLQVGDN 198
Cdd:cd21340   101 RLPPGeklTFD----PRSLAALSNSLRVLNisgnNIDslepLAPLRNLEQLDASNN 152
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-261 1.40e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.30  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  174 NRLQSLDRLTFEPLASLQLLQVGDNPWECDCNLREFKHWLEWFSYRGGRLDQLACTLPKELRGKDMRAVPMEM----FNY 249
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDsgcdEEY 84

                           90
                   ....*....|..
gi 1907171988  250 CSQLEDenNSAG 261
Cdd:TIGR00864   85 VACLKD--NSSG 94
LRR smart00370
Leucine-rich repeats, outliers;
91-114 3.95e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.33  E-value: 3.95e-04
                           10        20
                   ....*....|....*....|....
gi 1907171988   91 LSNLQRLDLSNNFLDQLPRSIFED 114
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-202 1.78e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.45  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  57 LGLTTVPPDVPAATQSLLLLNNKLSALPSwafaNL-SNLQRLDLSNNFLDQLPRSIfEDLVNLTELQlRNNSIrtldrDL 135
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPE----NLqGNIKTLYANSNQLTSIPATL-PDTIQEMELS-INRIT-----EL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988 136 LQHSP-LLRHLDLSINGLAQLPPGLFDGllaLRSLSLRSNRLQSL---------------DRLTFEPLA---SLQLLQVG 196
Cdd:PRK15370  257 PERLPsALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLpahlpsgithlnvqsNSLTALPETlppGLKTLEAG 333


                  ....*.
gi 1907171988 197 DNPWEC 202
Cdd:PRK15370  334 ENALTS 339
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 261-335 2.34e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907171988 261 GLDAPGPPCTKASPEPPK--PKPGAEPEPEPSTACPQKQRYRPVSVrraiGTVIIAGVvcgivcIMMVVAAAYGCIY 335
Cdd:PHA03264  319 GEPKPGPPRPAPDADRPEgwPSLEAITFPPPTPATPAVPRARPVIV----GTGIAAAA------IACVAAAGAVAYF 385
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
92-152 2.65e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 2.65e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907171988  92 SNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSIRTLDRDLLQHSPLLRHLDLSINGL 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-198 2.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  87 AFANLSNLQRLDLSNNFLDQLPRSIfEDLVNLTELQLRNNSIRTLDRDlLQHSPLLRHLDLSINGLAQLPPGLFDgllal 166
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELGN----- 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907171988 167 rslslrSNRLQSLD----RLTFEP-----LASLQLLQVGDN 198
Cdd:COG4886   181 ------LTNLKELDlsnnQITDLPeplgnLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-198 2.46e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 2.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  87 AFANLSNLQRLDLSNNFLDQLPRSIfEDLVNLTELQLRNNSIRTLDRDlLQHSPLLRHLDLSINGLAQLPPGLfdgllal 166
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPL------- 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1907171988 167 rslsLRSNRLQSLD----RLT----FEPLASLQLLQVGDN 198
Cdd:COG4886   225 ----ANLTNLETLDlsnnQLTdlpeLGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-192 1.07e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  87 AFANLSNLQRLDLSNNFLDQLPRSIfEDLVNLTELQLRNNSIRTLDRdlLQHSPLLRHLDLSINGLAQLPPGLfdgllal 166
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA------- 269

                          90       100
                  ....*....|....*....|....*.
gi 1907171988 167 rslslRSNRLQSLDrLTFEPLASLQL 192
Cdd:COG4886   270 -----NLTNLKTLD-LSNNQLTDLKL 289
LRR_8 pfam13855
Leucine rich repeat;
87-128 2.63e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 2.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907171988  87 AFANLSNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSI 128
Cdd:pfam13855  20 AFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
117-199 5.36e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988 117 NLTELQLRNNSIRTLDRDLLQHSPLLRHLDLsinglaqlppglfdgllalrslslRSNRLQSLDRLTFEPLASLQLLQVG 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL------------------------SNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ...
gi 1907171988 197 DNP 199
Cdd:pfam13855  58 GNR 60
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 38-67 8.15e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 8.15e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907171988  38 ACPFSCTCdsRSLEVDCSGLGLTTVPPDVP 67
Cdd:pfam01462   1 ACPVPCHC--SATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
38-71 9.21e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 9.21e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907171988   38 ACPFSCTCdsRSLEVDCSGLGLTTVPPDVPAATQ 71
Cdd:smart00013   1 ACPAPCNC--SGTAVDCSGRGLTEVPLDLPPDTT 32
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 93-132 4.42e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 4.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907171988  93 NLQRLDLSNNFLDQLPrsIFEDLVNLTELQL-RNNSIRTLD 132
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITDLS 40
LRRCT smart00082
Leucine rich repeat C-terminal domain;
198-247 5.83e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 5.83e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907171988  198 NPWECDCNLREFKHWLEWFSYRGGRLDqLACTLPKELRGKdMRAVPMEMF 247
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP-LLELLHSEF 48
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-198 8.11e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  93 NLQRLDLSNNFLDQLPRsiFEDLVNLTELQLRNNSIRTLDRdlLQHSPLLRHLDLS------INGLA------------- 153
Cdd:cd21340    25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGgnrisvVEGLEnltnleelhienq 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907171988 154 QLPPG---LFDgllaLRSLSLRSNRLQSLD----RLT----FEPLASLQLLQVGDN 198
Cdd:cd21340   101 RLPPGeklTFD----PRSLAALSNSLRVLNisgnNIDslepLAPLRNLEQLDASNN 152
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-261 1.40e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.30  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  174 NRLQSLDRLTFEPLASLQLLQVGDNPWECDCNLREFKHWLEWFSYRGGRLDQLACTLPKELRGKDMRAVPMEM----FNY 249
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDsgcdEEY 84

                           90
                   ....*....|..
gi 1907171988  250 CSQLEDenNSAG 261
Cdd:TIGR00864   85 VACLKD--NSSG 94
LRR smart00370
Leucine-rich repeats, outliers;
91-114 3.95e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.33  E-value: 3.95e-04
                           10        20
                   ....*....|....*....|....
gi 1907171988   91 LSNLQRLDLSNNFLDQLPRSIFED 114
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
91-114 3.95e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 37.33  E-value: 3.95e-04
                           10        20
                   ....*....|....*....|....
gi 1907171988   91 LSNLQRLDLSNNFLDQLPRSIFED 114
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-152 1.22e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907171988  87 AFANLSNLQRLDLSNNFLDQLPRSIFEDL---VNLTELQLRNNSI-----RTLDRDLLQHSPLLRHLDLSINGL 152
Cdd:cd00116    76 GLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRL 149
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-128 1.40e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  40 PFSCTCDSRSLEV-DCSGLGLTTVPPdvpaatqsllllnnklsalpswaFANLSNLQRLDLSNNFLDQLPR--SIFEDLV 116
Cdd:cd21340   112 PRSLAALSNSLRVlNISGNNIDSLEP-----------------------LAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                          90
                  ....*....|..
gi 1907171988 117 NLTELQLRNNSI 128
Cdd:cd21340   169 SLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-202 1.78e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.45  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988  57 LGLTTVPPDVPAATQSLLLLNNKLSALPSwafaNL-SNLQRLDLSNNFLDQLPRSIfEDLVNLTELQlRNNSIrtldrDL 135
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPE----NLqGNIKTLYANSNQLTSIPATL-PDTIQEMELS-INRIT-----EL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171988 136 LQHSP-LLRHLDLSINGLAQLPPGLFDGllaLRSLSLRSNRLQSL---------------DRLTFEPLA---SLQLLQVG 196
Cdd:PRK15370  257 PERLPsALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLpahlpsgithlnvqsNSLTALPETlppGLKTLEAG 333


                  ....*.
gi 1907171988 197 DNPWEC 202
Cdd:PRK15370  334 ENALTS 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 117-150 1.93e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907171988 117 NLTELQLRNNSIRTLdrDLLQHSPLLRHLDLSIN 150
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 261-335 2.34e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907171988 261 GLDAPGPPCTKASPEPPK--PKPGAEPEPEPSTACPQKQRYRPVSVrraiGTVIIAGVvcgivcIMMVVAAAYGCIY 335
Cdd:PHA03264  319 GEPKPGPPRPAPDADRPEgwPSLEAITFPPPTPATPAVPRARPVIV----GTGIAAAA------IACVAAAGAVAYF 385
LRR smart00370
Leucine-rich repeats, outliers;
142-162 8.76e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 8.76e-03
                           10        20
                   ....*....|....*....|.
gi 1907171988  142 LRHLDLSINGLAQLPPGLFDG 162
Cdd:smart00370   4 LRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
142-162 8.76e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 8.76e-03
                           10        20
                   ....*....|....*....|.
gi 1907171988  142 LRHLDLSINGLAQLPPGLFDG 162
Cdd:smart00369   4 LRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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