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Conserved domains on  [gi|1907156589|ref|XP_036020128|]
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enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X2 [Mus musculus]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-161 2.34e-66

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PRK07657:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 260  Bit Score: 202.66  E-value: 2.34e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK07657  104 INGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKEIGLVEFVV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK07657  184 PAHL----LEEKAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIEKQAYEGTIPTKDRLEGLQAFKEKRKPMYKG 259


                  .
gi 1907156589 161 K 161
Cdd:PRK07657  260 E 260
 
Name Accession Description Interval E-value
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 1-161 2.34e-66

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 202.66  E-value: 2.34e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK07657  104 INGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKEIGLVEFVV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK07657  184 PAHL----LEEKAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIEKQAYEGTIPTKDRLEGLQAFKEKRKPMYKG 259


                  .
gi 1907156589 161 K 161
Cdd:PRK07657  260 E 260
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-155 2.28e-50

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 161.49  E-value: 2.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:COG1024    99 VNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRRIDAEEALELGLVNRVV 178

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRA 155
Cdd:COG1024   179 PDDE----LLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFLEKRK 249
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-161 1.07e-35

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 124.01  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:pfam00378  95 VNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQEALKWGLVDKVV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:pfam00378 175 PEDQ----LLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIEGLQAFLEKRKPPWED 250


                  .
gi 1907156589 161 K 161
Cdd:pfam00378 251 Q 251
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-100 6.80e-33

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 115.35  E-value: 6.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:cd06558   100 VNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRRISAEEALELGLVDEVV 179

                          90       100
                  ....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEI 100
Cdd:cd06558   180 PDEE----LLAAALELARRL 195
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 3-117 7.50e-20

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 85.27  E-value: 7.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAA--SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:TIGR02441 117 GSCLGGGLELALACHYRIATkdRKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIRADRAKKMGIVDQLV 196

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907156589  81 AQNEEG-NAAYHRALALAQEILPQAPIAVRLGKVAIDR 117
Cdd:TIGR02441 197 DPLGPGlKPAEENTIEYLEEVAVKFAQGLANGKLSINR 234
 
Name Accession Description Interval E-value
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 1-161 2.34e-66

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 202.66  E-value: 2.34e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK07657  104 INGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKEIGLVEFVV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK07657  184 PAHL----LEEKAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIEKQAYEGTIPTKDRLEGLQAFKEKRKPMYKG 259


                  .
gi 1907156589 161 K 161
Cdd:PRK07657  260 E 260
PLN02600 PLN02600
enoyl-CoA hydratase
 1-161 2.83e-66

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 202.34  E-value: 2.83e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PLN02600   95 VEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREAASMGLVNYCV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PLN02600  175 PAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGLAAFAEKRKPVYTG 250


                  .
gi 1907156589 161 K 161
Cdd:PLN02600  251 K 251
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
1-161 2.18e-50

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 162.22  E-value: 2.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK05809  104 INGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPGFGGTQRLARIVGPGKAKELIYTGDMINAEEALRIGLVNKVV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEGNAAYhralALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK05809  184 EPEKLMEEAK----ALANKIAANAPIAVKLCKDAINRGMQVDIDTAVAIEAEDFGECFSTEDQTEGMTAFVEKREKNFKN 259


                  .
gi 1907156589 161 K 161
Cdd:PRK05809  260 K 260
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-155 2.28e-50

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 161.49  E-value: 2.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:COG1024    99 VNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRRIDAEEALELGLVNRVV 178

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRA 155
Cdd:COG1024   179 PDDE----LLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFLEKRK 249
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 2-161 3.37e-41

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 138.36  E-value: 3.37e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHaVA 81
Cdd:PRK09674  100 NGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPGAGGTQRLIRSVGKSLASQMVLTGESITAQQAQQAGLVSE-VF 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QNEegnAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK09674  179 PPE---LTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFTLLAATEDRHEGISAFLEKRTPDFKGR 255
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 2-161 8.91e-40

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 134.78  E-value: 8.91e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK06494  102 NGVAMGGGFELALACDLIVAAENATFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMILTGRRVTAREGLELGFVNEVVP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QnEEGNAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAiEQMCY---AQNIPTQDRLEGMAAFREKRAPKF 158
Cdd:PRK06494  182 A-GELLAA---AERWADDILACSPLSIRASKQAVYRGLEVSLEEAIT-AQRDYpavEARRASQDYIEGPKAFAEKRPPRW 256


                  ...
gi 1907156589 159 VGK 161
Cdd:PRK06494  257 KGR 259
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 3-156 6.44e-39

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 132.35  E-value: 6.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK09076  104 GYAMGGGLECALACDIRIAEEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMILCGERVDAATALRIGLVEEVVEK 183

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAP 156
Cdd:PRK09076  184 GE----AREAALALAQKVANQSPSAVAACKTLIQAARNGPRAAALALERELFVDLFDTEDQREGVNAFLEKRAP 253
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 3-161 5.75e-38

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 130.14  E-value: 5.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK07658  103 GAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPITGAEALKWGLVNGVFPE 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK07658  183 ET----LLDDAKKLAKKIAGKSPATTRAVLELLQTTKSSSYYEGVKREAKIFGEVFTSEDAKEGVQAFLEKRKPSFSGK 257
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 3-158 9.88e-36

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 124.38  E-value: 9.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK05862  103 GYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMMDAAEAERAGLVSRVVPA 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKF 158
Cdd:PRK05862  183 DK----LLDEALAAATTIASFSLPAVMMAKEAVNRAYETTLAEGLLFERRLFHSLFATEDQKEGMAAFVEKRKPVF 254
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-161 1.07e-35

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 124.01  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:pfam00378  95 VNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQEALKWGLVDKVV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:pfam00378 175 PEDQ----LLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIEGLQAFLEKRKPPWED 250


                  .
gi 1907156589 161 K 161
Cdd:pfam00378 251 Q 251
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 2-161 2.44e-34

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 120.74  E-value: 2.44e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK06688  104 NGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALLPRLIGRARAAEMLLLGEPLSAEEALRIGLVNRVVP 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 qNEEGNAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK06688  184 -AAELDAE---ADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPDFREGATAFIEKRKPDFTGF 259
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 3-161 9.77e-34

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 119.39  E-value: 9.77e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK08138  107 GYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPGAGGTQRLVRAVGKFKAMRMALTGCMVPAPEALAIGLVSEVVED 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK08138  187 EQ----TLPRALELAREIARMPPLALAQIKEVVLAGADAPLDAALALERKAFQLLFDSEDQKEGMDAFLEKRKPAYKGK 261
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-100 6.80e-33

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 115.35  E-value: 6.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:cd06558   100 VNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRRISAEEALELGLVDEVV 179

                          90       100
                  ....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEI 100
Cdd:cd06558   180 PDEE----LLAAALELARRL 195
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
2-161 3.72e-31

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 112.39  E-value: 3.72e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVa 81
Cdd:PRK08252   99 EGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMELALTGDMLTAERAHELGLVNRLT- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 qneEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDiASGMAIEQMCYAQNIPT-QDRLEGMAAFREKRAPKFVG 160
Cdd:PRK08252  178 ---EPGQALDAALELAERIAANGPLAVAASKRIVVESGDWS-EDEMFARQRELIAPVFTsADAKEGATAFAEKRAPVWTG 253


                  .
gi 1907156589 161 K 161
Cdd:PRK08252  254 K 254
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 1-161 6.52e-29

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 107.10  E-value: 6.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK06127  113 IRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGLGYGYDGVKNLVDLVGPSAAKDLFYTARRFDAAEALRIGLVHRVT 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEGNAAYHRALALAQeilpQAPIAVRLGKVAIDR----GMEVDIASGMAIEQMCYAqnipTQDRLEGMAAFREKRAP 156
Cdd:PRK06127  193 AADDLETALADYAATIAG----NAPLTLRAAKRAIAEllkdEPERDMAACQALVAACFD----SEDYREGRAAFMEKRKP 264


                  ....*
gi 1907156589 157 KFVGK 161
Cdd:PRK06127  265 VFKGR 269
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
2-161 3.55e-27

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 102.08  E-value: 3.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK03580  102 NGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMDAEEALRWGIVNRVVP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIP----TQDRLEGMAAFREKRAPK 157
Cdd:PRK03580  182 QAE----LMDRARELAQQLVNSAPLAIAALKEIYRETSEMPVEEAYRYIRSGVLKHYPsvlhSEDALEGPRAFAEKRDPV 257


                  ....
gi 1907156589 158 FVGK 161
Cdd:PRK03580  258 WKGR 261
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
3-161 1.34e-26

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 100.82  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK09245  112 GPAIGAGCDLACMCDIRIASETARFAESFVKLGLIPGDGGAWLLPRIIGMARAAEMAFTGDAIDAATALEWGLVSRVVPA 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK09245  192 DQ----LLPAARALAERIAANPPHALRLTKRLLREGQHASLDTLLELSAAYQALAHHTADHREAVDAFLEKRPPVFTGR 266
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
2-158 1.97e-25

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 97.52  E-value: 1.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK05980  108 NGLAFGGGCEITEAVHLAIASERALFAKPEIRLGMPPTFGGTQRLPRLAGRKRALELLLTGDAFSAERALEIGLVNAVVP 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907156589  82 QNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKF 158
Cdd:PRK05980  188 HEELLPA----ARALARRIIRHSPVAVAAILTAVTRGLNLSIAEGLLIESEQFARMAGSADLREGLAAWIERRRPAY 260
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
3-159 2.01e-25

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 97.64  E-value: 2.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK07509  111 GVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRKDVARELTYTARVFSAEEALELGLVTHVSDD 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907156589  83 NEEgnaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFV 159
Cdd:PRK07509  191 PLA------AALALAREIAQRSPDAIAAAKRLINRSWTASVRALLARESVEQIRLLLGKNQKIAVKAQMKKRAPKFL 261
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
3-82 4.82e-25

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 99.97  E-value: 4.82e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSA--VMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK11154  110 GACLGGGLELALACHYRVCTDDPktVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALDMILTGKQLRAKQALKLGLVDDVV 189


                  ..
gi 1907156589  81 AQ 82
Cdd:PRK11154  190 PH 191
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
3-160 6.73e-25

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 96.58  E-value: 6.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK06142  118 GWCIGGGVDLISACDMRYASADAKFSVREVDLGMVADVGSLQRLPRIIGDGHLRELALTGRDIDAAEAEKIGLVNRVYDD 197

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907156589  83 NEEGNAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK06142  198 ADALLAA---AHATAREIAAKSPLAVRGTKEVLDYMRDHRVADGLRYVATWNAAMLPSKDLTEAIAAHMEKRPPEFTG 272
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
2-161 1.42e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 95.55  E-value: 1.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK07799  108 EGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDLLLTGRHITAAEAKEIGLIGHVVP 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK07799  188 DGQ----ALDKALELAELINANGPLAVQAILRTIRETEGMHENEAFKIDTKIGIPVFLSEDAKEGPRAFAEKRAPNFQGR 263
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 3-152 6.02e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 93.50  E-value: 6.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK06190  103 GAAVTGGLELALACDILIASERARFADTHARVGILPGWGLSVRLPQKVGIGRARRMSLTGDFLDAADALRAGLVTEVVPH 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQmCYAQNIPTQDRLEGMAAFRE 152
Cdd:PRK06190  183 DE----LLPRARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALEA-EAARAHNRSVSPDGIAARRE 247
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 2-160 8.70e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 93.14  E-value: 8.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVa 81
Cdd:PRK07511  106 EGAAAGAGFSLALACDLLVAARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEGKPISAERLHALGVVNRLA- 184

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589  82 qneEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK07511  185 ---EPGQALAEALALADQLAAGSPNALARIKSLIADAPEATLAAQLEAERDHFVASLHHADALEGIAAFLEKRAPDYKR 260
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
3-161 8.10e-23

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 90.79  E-value: 8.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK06563  101 GYCLTLGIELMLAADIVVAADNTRFAQLEVQRGILPFGGATLRFPQAAGWGNAMRYLLTGDEFDAQEALRLGLVQEVVPP 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEEgnaaYHRALALAQEILPQAPIAVRL----GKVAIDRGMEVDIASGMAIEQMCYAqnipTQDRLEGMAAFREKRAPKF 158
Cdd:PRK06563  181 GEQ----LERAIELAERIARAAPLGVQAtlasARAAVREGEAAAAAQLPPELRPLFT----SEDAKEGVQAFLERRPARF 252


                  ...
gi 1907156589 159 VGK 161
Cdd:PRK06563  253 KGR 255
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
3-127 2.25e-22

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 92.23  E-value: 2.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK11730  111 GYALGGGCECVLATDYRVASPDARIGLPETKLGIMPGFGGTVRLPRLIGADNALEWIAAGKDVRAEDALKVGAVDAVVAP 190

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907156589  83 NEEGNAAYHRA-LALAQEILPQAPIAVRLGKV---AIDRGMEVDIASGM 127
Cdd:PRK11730  191 EKLQEAALALLkQAIAGKLDWKARRQPKLEPLklsKIEAMMSFTTAKGM 239
PLN02888 PLN02888
enoyl-CoA hydratase
 3-157 2.86e-22

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 89.43  E-value: 2.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PLN02888  108 GFAITAGFEIALACDILVASRGAKFIDTHAKFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTAETAERWGLVNHVVEE 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQ---MCYAQNIpTQDRLEGMAAFREKRAPK 157
Cdd:PLN02888  188 SE----LLKKAREVAEAIIKNNQGMVLRYKSVINDGLKLDLGHALQLEKeraHDYYNGM-TKEQFQKMQEFIAGRSSK 260
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 1-161 1.59e-21

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 87.36  E-value: 1.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGL-IETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHA 79
Cdd:PRK06144  109 IAGACVGGGAAIAAACDLRIATPSARFGFpIARTLGNCLSMSNLARLVALLGAARVKDMLFTARLLEAEEALAAGLVNEV 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  80 VAQNEEGNaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAqnipTQDRLEGMAAFREKRAPKFV 159
Cdd:PRK06144  189 VEDAALDA----RADALAELLAAHAPLTLRATKEALRRLRREGLPDGDDLIRMCYM----SEDFREGVEAFLEKRPPKWK 260


                  ..
gi 1907156589 160 GK 161
Cdd:PRK06144  261 GR 262
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 1-161 9.76e-21

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 85.53  E-value: 9.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK06210  115 INGACAGIGLTHALMCDVRFAADGAKFTTAFARRGLIAEHGISWILPRLVGHANALDLLLSARTFYAEEALRLGLVNRVV 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEGNAAYHRALALAQEILPqAPIAVRLGKVAIDRGMEVDIASGMAIEQMcyAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK06210  195 PPDELMERTLAYAEDLARNVSP-ASMAVIKRQLYEDAFQTLAEATARANREM--HESLQRPDFIEGVASFLEKRPPRFPG 271


                  .
gi 1907156589 161 K 161
Cdd:PRK06210  272 L 272
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
2-161 1.24e-20

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 85.13  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLlpgAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK06495  105 NGPALGAGLGLVASCDIIVASENAVFGLPEIDVGL---AGGGKHAMRLFGHSLTRRMMLTGYRVPAAELYRRGVIEACLP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK06495  182 PEE----LMPEAMEIAREIASKSPLATRLAKDALNTIENMSLRDGYRYEQDITAKLAKTEDAKEAQRAFLEKRPPVFKGR 257
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 3-117 7.50e-20

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 85.27  E-value: 7.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAA--SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:TIGR02441 117 GSCLGGGLELALACHYRIATkdRKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIRADRAKKMGIVDQLV 196

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907156589  81 AQNEEG-NAAYHRALALAQEILPQAPIAVRLGKVAIDR 117
Cdd:TIGR02441 197 DPLGPGlKPAEENTIEYLEEVAVKFAQGLANGKLSINR 234
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 3-161 1.77e-19

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 82.00  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHaVAQ 82
Cdd:PRK11423  105 GSVWGGAFELIMSCDLIIAASTSTFAMTPANLGVPYNLSGILNFTNDAGFHIVKEMFFTASPITAQRALAVGILNH-VVE 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEEGNAAyhrALALAQEILPQAPIAVRLGKvaidrgMEVDI---ASGMAIEQMCYAQNI-----PTQDRLEGMAAFREKR 154
Cdd:PRK11423  184 VEELEDF---TLQMAHHISEKAPLAIAVIK------EQLRVlgeAHPMNPDEFERIQGLrravyDSEDYQEGMNAFLEKR 254


                  ....*..
gi 1907156589 155 APKFVGK 161
Cdd:PRK11423  255 KPVFVGH 261
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 3-158 6.80e-19

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 80.72  E-value: 6.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PLN02664  120 GACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIVGYGNAMELALTGRRFSGSEAKELGLVSRVFGS 199

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907156589  83 NEEGNAAYHralALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKF 158
Cdd:PLN02664  200 KEDLDEGVR---LIAEGIAAKSPLAVTGTKAVLLRSRELSVEQGLDYVATWNSAMLVSDDLNEAVSAQIQKRKPVF 272
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
1-157 8.15e-19

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 80.06  E-value: 8.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK08150   99 LHGAVVGGGLELASAAHIRVADESTYFALPEGQRGIFVGGGGSVRVPRLIGVARMTDMMLTGRVYDAQEGERLGLAQYLV 178

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPK 157
Cdd:PRK08150  179 PAGE----ALDKAMELARRIAQNAPLTNFAVLNALPRIADMSADDGLFVESLMAAVAQSAPEAKERLRAFLEKKAAK 251
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 1-158 1.51e-18

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 79.51  E-value: 1.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:TIGR01929 104 VNGYAIGGGHVLHMMCDLTIAAENARFGQTGPKVGSFDGGYGSSYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGmaieQMCYAQNIP-----TQDRLEGMAAFREKRA 155
Cdd:TIGR01929 184 PLADLEKE----TVRWCREILQKSPMAIRMLKAALN--ADCDGQAG----LQELAGNATmlfymTEEGQEGRNAFLEKRQ 253


                  ...
gi 1907156589 156 PKF 158
Cdd:TIGR01929 254 PDF 256
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 3-157 2.73e-18

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 78.90  E-value: 2.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV-- 80
Cdd:PRK09120  113 GWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALYYIMTGETFTGRKAAEMGLVNESVpl 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASG-----MAIEQMCYAQniPTQDRLEGMAAFREKRA 155
Cdd:PRK09120  193 AQLRA------RTRELAAKLLEKNPVVLRAAKDGFKRVRELTWDQAedylyAKLEQANSLD--PEGGREEGLKQFLDDKS 264


                  ..
gi 1907156589 156 PK 157
Cdd:PRK09120  265 YK 266
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
3-104 4.42e-18

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 78.01  E-value: 4.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMG---------LIEttrgllpgaGGTQRLPRCLGVALAKELIFTGRRLNGAQAREL 73
Cdd:PRK08259  102 GYAVAGGLELALWCDLRVAEEDAVFGvfcrrwgvpLID---------GGTVRLPRLIGHSRAMDLILTGRPVDADEALAI 172

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907156589  74 GLVNHAVAQNEegnaAYHRALALAQEI--LPQA 104
Cdd:PRK08259  173 GLANRVVPKGQ----ARAAAEELAAELaaFPQT 201
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 3-161 8.97e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 77.74  E-value: 8.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK08260  122 GPAVGVGATMTLAMDIRLASTAARFGFVFGRRGIVPEAASSWFLPRLVGLQTALEWVYSGRVFDAQEALDGGLVRSVHPP 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEEGNAAYhralALAQEILPQ-APIAVRLGKVAIDRGMEVDI-ASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK08260  202 DELLPAAR----ALAREIADNtSPVSVALTRQMMWRMAGADHpMEAHRVDSRAIYSRGRSGDGKEGVSSFLEKRPAVFPG 277


                  .
gi 1907156589 161 K 161
Cdd:PRK08260  278 K 278
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 3-161 2.67e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 76.11  E-value: 2.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVaq 82
Cdd:PRK08140  108 GVAAGAGANLALACDIVLAARSASFIQAFVKIGLVPDSGGTWFLPRLVGMARALGLALLGEKLSAEQAEQWGLIWRVV-- 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589  83 neEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 161
Cdd:PRK08140  186 --DDAALADEAQQLAAHLATQPTRGLALIKQAMNASATNTLDAQLDLERDLQREAGRSADYAEGVSAFLEKRAPRFTGR 262
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 3-116 9.69e-17

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 74.11  E-value: 9.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK05869  108 GYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGLIDEMVAP 187

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKVAID 116
Cdd:PRK05869  188 DD----VYDAAAAWARRFLDGPPHALAAAKAGIS 217
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 3-161 1.31e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 74.19  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgaggTQRLP---RCLGVALAKELIFTGRRLNGAQARELGLVNHA 79
Cdd:PRK05995  108 GDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIP----ATISPyviRAMGERAARRYFLTAERFDAAEALRLGLVHEV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  80 VAQnEEGNAAYHralALAQEILPQAPIAVRLGKVAIDrgmevDIAsGMAIEQMCYAQnipTQDRL----------EGMAA 149
Cdd:PRK05995  184 VPA-EALDAKVD---ELLAALVANSPQAVRAGKRLVR-----DVA-GRPIDAALIAD---TASRIalirateearEGVAA 250

                         170
                  ....*....|..
gi 1907156589 150 FREKRAPKFVGK 161
Cdd:PRK05995  251 FLEKRKPAWRGR 262
MenB COG0447
1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1, ...
 3-158 1.44e-15

1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1,4-Dihydroxy-2-naphthoyl-CoA synthase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440216  Cd Length: 281  Bit Score: 71.77  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV-- 80
Cdd:COG0447   126 GWAIGGGHVLHVVCDLTIASENARFGQTGPDVGSFDAGYGSAYLARQVGQKKAREIWFLCRQYSAQEALEMGLVNKVVph 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDrgMEVDiasGMAIEQ--------MCYAqnipTQDRLEGMAAFRE 152
Cdd:COG0447   206 AELEE------EAVEWAREILEKSPTAIRMLKAAFN--ADDD---GLAGQQefageatrLAYM----TDEAQEGRDAFLE 270


                  ....*.
gi 1907156589 153 KRAPKF 158
Cdd:COG0447   271 KRKPDF 276
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 3-158 2.73e-15

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 70.69  E-value: 2.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV-- 80
Cdd:PRK07396  116 GYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGYGASYLARIVGQKKAREIWFLCRQYDAQEALDMGLVNTVVpl 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGmaIEQMcyAQNIP-----TQDRLEGMAAFREKRA 155
Cdd:PRK07396  196 ADLEK------ETVRWCREMLQNSPMALRCLKAALN--ADCDGQAG--LQEL--AGNATmlfymTEEAQEGRNAFNEKRQ 263


                  ...
gi 1907156589 156 PKF 158
Cdd:PRK07396  264 PDF 266
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 2-156 3.22e-15

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 70.74  E-value: 3.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLL---PGAGgtqrLPRCLGVALAKELIFTGRRLNGAQARELGLVNH 78
Cdd:PRK08139  112 HGIATAAGCQLVASCDLAVAADTARFAVPGVNIGLFcstPMVA----LSRNVPRKQAMEMLLTGEFIDAATAREWGLVNR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  79 AVAQNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDR--GMEVDIASGMAIEQMcyAQNIPTQDRLEGMAAFREKRAP 156
Cdd:PRK08139  188 VVPADALDAA----VARLAAVIAAKSPAAVRIGKEAFYRqaEMPLADAYAYAGDVM--AENMMAEDAEEGIDAFLEKRPP 261
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 3-157 5.27e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 70.38  E-value: 5.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAV-------MGliettrgllpgAGGTQRL--PRCLGVALAKELIFTGRRLNGAQAREL 73
Cdd:PRK08290  127 GACIAGGLMLAWVCDLIVASDDAFfsdpvvrMG-----------IPGVEYFahPWELGPRKAKELLFTGDRLTADEAHRL 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  74 GLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDR-----GMEVDIASGMAIEQMCYAQNIPTQD------ 142
Cdd:PRK08290  196 GMVNRVVPRDE----LEAETLELARRIAAMPPFGLRLTKRAVNQtldaqGFRAALDAVFDLHQLGHAHNAEVGGdrlgga 271

                         170
                  ....*....|....*
gi 1907156589 143 RLEGMAAFREKRAPK 157
Cdd:PRK08290  272 DARGMADARKAAAAK 286
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
2-161 8.47e-15

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 69.38  E-value: 8.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK05981  111 NGPAAGVGMSFALMGDLILCARSAYFLQAFRRIGLVPDGGSTWLLPRLVGKARAMELSLLGEKLPAETALQWGLVNRVVD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEqmCYAQNIP--TQDRLEGMAAFREKRAPKFV 159
Cdd:PRK05981  191 DAE----LMAEAMKLAHELANGPTVALGLIRKLYWDSPENDFEEQLNLE--REAQRIAgkTEDFKEGVGAFLQKRPAQFK 264


                  ..
gi 1907156589 160 GK 161
Cdd:PRK05981  265 GR 266
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
2-160 1.18e-14

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 69.22  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLlPGA--GGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHA 79
Cdd:PRK08258  121 DGVCAGAGAILAMASDLRLGTPSAKTAFLFTRVGL-AGAdmGACALLPRIIGQGRASELLYTGRSMSAEEGERWGFFNRL 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  80 VAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGMAIEQMCYAQNI--PTQDRLEGMAAFREKRAPK 157
Cdd:PRK08258  200 VEPEE----LLAEAQALARRLAAGPTFAHGMTKTMLH--QEWDMGLEEAIEAEAQAQAIcmQTEDFRRAYEAFVAKRKPV 273


                  ...
gi 1907156589 158 FVG 160
Cdd:PRK08258  274 FEG 276
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 1-154 1.23e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 68.91  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGlLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVnHAV 80
Cdd:PRK06143  107 IPGWCLGGGLELAAACDLRIAAHDAQFGMPEVRVG-IPSVIHAALLPRLIGWARTRWLLLTGETIDAAQALAWGLV-DRV 184

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907156589  81 AQNEEGNAAYHRalaLAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKR 154
Cdd:PRK06143  185 VPLAELDAAVER---LAASLAGCGPQALRQQKRLLREWEDMPLDVAIDDSVAEFGAAFLTGEPQRHMAAFLNRK 255
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 3-161 1.29e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 68.91  E-value: 1.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNhAVAQ 82
Cdd:PRK07659  107 GPAAGLGLSIALTADYVIADISAKLAMNFIGIGLIPDGGGHFFLQKRVGENKAKQIIWEGKKLSATEALDLGLID-EVIG 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEEGNAAYHRALALAQEILpQAPIA-----VRLGKVAIDRGMEVDIASGMAIEQmcyaqnipTQDRLEGMAAFREKRAPK 157
Cdd:PRK07659  186 GDFQTAAKQKISEWLQKPL-KAMIEtkqiyCELNRSQLEQVLQLEKRAQYAMRQ--------TADHKEGIRAFLEKRLPV 256


                  ....
gi 1907156589 158 FVGK 161
Cdd:PRK07659  257 FKGE 260
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
3-161 6.46e-14

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 67.01  E-value: 6.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK07468  109 GQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATISPYVVAR-MGEANARRVFMSARLFDAEEAVRLGLLSRVVPA 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 nEEGNAAYHRALAlaqEILPQAPIAV-RLGKVAIDRGMEVDIAS-GMAIEQMcyAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK07468  188 -ERLDAAVEAEVT---PYLSCAPGAVaAAKALVRALGAPIDEAViDATIEAL--ADTWETEEAREGIAAFFDKRAPAWRG 261


                  .
gi 1907156589 161 K 161
Cdd:PRK07468  262 G 262
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
1-158 2.32e-13

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 65.43  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK07327  113 IHGPAVGAGLVAALLADISIAAKDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCEPVSGEEAERIGLVSLAV 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEegnaAYHRALALAQEILPQAPIAVRLGKVAID---RGMEVDIASGMAIEQMCYAqnipTQDRLEGMAAFREKRAPK 157
Cdd:PRK07327  193 DDDE----LLPKALEVAERLAAGSQTAIRWTKYALNnwlRMAGPTFDTSLALEFMGFS----GPDVREGLASLREKRAPD 264


                  .
gi 1907156589 158 F 158
Cdd:PRK07327  265 F 265
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 3-161 6.21e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 63.89  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVnhavaq 82
Cdd:PRK07854   95 GPAIGAGLQLAMACDLRVVAPEAYFQFPVAKYGIALDNWTIRRLSSLVGGGRARAMLLGAEKLTAEQALATGMA------ 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEEGNAAyhRALALAQEILPQAPIAVRLGKVAI--DRGMEVDIASGMAIEQMCYAqnipTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK07854  169 NRIGTLA--DAQAWAAEIAGLAPLALQHAKRVLndDGAIEEAWPAHKELFDKAWA----SQDAIEAQVARIEKRPPKFQG 242


                  .
gi 1907156589 161 K 161
Cdd:PRK07854  243 A 243
PLN02921 PLN02921
naphthoate synthase
 3-158 1.59e-12

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 63.65  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV-- 80
Cdd:PLN02921  170 GYAVGGGHILHMVCDLTIAADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMWFLARFYTASEALKMGLVNTVVpl 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEGNAAYHRalalaqEILPQAPIAVRLGKVAIDRGMevDIASGmaIEQMcyAQNIP-----TQDRLEGMAAFREKRA 155
Cdd:PLN02921  250 DELEGETVKWCR------EILRNSPTAIRVLKSALNAAD--DGHAG--LQEL--GGNATllfygSEEGNEGRTAYLEGRA 317


                  ...
gi 1907156589 156 PKF 158
Cdd:PLN02921  318 PDF 320
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 3-89 2.69e-12

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 62.62  E-value: 2.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVnHAVAQ 82
Cdd:PRK08788  130 GDALGGGFEAALSHHTIIAERGAKMGFPEILFNLFPGMGAYSFLARRVGPKLAEELILSGKLYTAEELHDMGLV-DVLVE 208


                  ....*..
gi 1907156589  83 NEEGNAA 89
Cdd:PRK08788  209 DGQGEAA 215
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-117 3.91e-12

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 62.49  E-value: 3.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRC---LGVALAkeliFTGRRLNGAQARELGLVN 77
Cdd:pfam16113  95 MDGIVMGGGVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLpgeLGLYLA----LTGARLNGADALAAGLAT 170

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907156589  78 HAV-------------AQNEEGNAAYHRALALAQEILPQAPIAVRLGKVAIDR 117
Cdd:pfam16113 171 HYVpsarlpaleealaALDWSDPADVDAVLAEFAEESDPPPSPLAAHREAIDR 223
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 1-98 7.19e-12

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 61.14  E-value: 7.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK07110  101 MQGHAIGGGLVLGLYADIVVLSRESVYTANFMKYGFTPGMGATAILPEKLGLALGQEMLLTARYYRGAELKKRGVPFPVL 180

                          90
                  ....*....|....*...
gi 1907156589  81 AQNEEGNAAYHRALALAQ 98
Cdd:PRK07110  181 PRAEVLEKALELARSLAE 198
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 1-160 7.30e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 61.33  E-value: 7.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLNGAQARELGLVNhaV 80
Cdd:PRK06072   96 INGVTAGACIGIALSTDFKFASRDVKFVTAFQRLGLASDTGVAYFLLK-LTGQRFYEILVLGGEFTAEEAERWGLLK--I 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNeegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVG 160
Cdd:PRK06072  173 SED-----PLSDAEEMANRISNGPFQSYIAAKRMINLVLYNDLEEFLEYESAIQGYLGKTEDFKEGISSFKEKREPKFKG 247
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 1-159 8.30e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 61.39  E-value: 8.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGA-GGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHA 79
Cdd:PRK05864  116 VNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTASElGLSYLLPRAIGSSRAFEIMLTGRDVDAEEAERIGLVSRQ 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  80 VAQNEEGNAAYhralALAQEILPQAPIAVRLGKVAIDRGMevDIASGMA-IEQMCYAQ---NIPTQDRLEGMAAFREKRA 155
Cdd:PRK05864  196 VPDEQLLDTCY----AIAARMAGFSRPGIELTKRTLWSGL--DAASLEAhMQAEGLGQlfvRLLTANFEEAVAARAEKRP 269


                  ....
gi 1907156589 156 PKFV 159
Cdd:PRK05864  270 PVFT 273
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
3-158 7.52e-11

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 58.88  E-value: 7.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASS-AVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK08321  144 GWAAGGGHSLHVVCDLTLASREhARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYSAEEAHDMGAVNAVVP 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  82 QNEEGNAayhrALALAQEILPQAPIAVRLGKVA---IDRGM-EVDIASGMAIeQMCYAqnipTQDRLEGMAAFREKRAPK 157
Cdd:PRK08321  224 HAELETE----ALEWAREINGKSPTAMRMLKYAfnlTDDGLvGQQLFAGEAT-RLAYM----TDEAQEGRDAFLEKRDPD 294


                  .
gi 1907156589 158 F 158
Cdd:PRK08321  295 W 295
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
3-115 7.67e-11

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 58.44  E-value: 7.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLprcLGVALAKELIFTGRRLNGAQARELGLVnHAVAQ 82
Cdd:PRK07938  103 GFCLGGGIGLVGNADVIVASDDATFGLPEVDRGALGAATHLQRL---VPQHLMRALFFTAATITAAELHHFGSV-EEVVP 178

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907156589  83 NEEGNAAyhrALALAQEILPQAPIAVRLGKVAI 115
Cdd:PRK07938  179 RDQLDEA---ALEVARKIAAKDTRVIRAAKEAL 208
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
3-80 6.68e-09

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 53.12  E-value: 6.68e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIET-TRGLLPGAGGTQRLprclGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK08272  136 GYCVAGGTDIALHCDQVIAADDAKIGYPPTrVWGVPATGMWAYRL----GPQRAKRLLFTGDCITGAQAAEWGLAVEAV 210
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 1-84 2.42e-08

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 51.74  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK05617  107 MDGIVMGGGVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPG-ALGTYLALTGARISAADALYAGLADHFV 185


                  ....
gi 1907156589  81 AQNE 84
Cdd:PRK05617  186 PSAD 189
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
2-150 3.48e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 50.95  E-value: 3.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVA 81
Cdd:PRK06023  105 DGLAIGIGTTIHLHCDLTFASPRSLFRTPFVDLALVPEAGSSLLAPRLMGHQRAFALLALGEGFSAEAAQEAGLIWKIVD 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156589  82 QneegNAAYHRALALAQEILPQAPIAVRLGKVAIdRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAF 150
Cdd:PRK06023  185 E----EAVEAETLKAAEELAAKPPQALQIARDLM-RGPREDILARIDEEAKHFAARLKSAEARAAFEAF 248
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 3-76 4.02e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 50.88  E-value: 4.02e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLV 76
Cdd:PRK05870  104 GAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEAAVRHGLA 177
PLN02851 PLN02851
3-hydroxyisobutyryl-CoA hydrolase-like protein
 1-78 2.57e-07

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178443 [Multi-domain]  Cd Length: 407  Bit Score: 48.82  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGT---QRLPRCLGVALAkeliFTGRRLNGAQARELGLVN 77
Cdd:PLN02851  145 MDGITMGCGAGISIPGMFRVVTDKTVFAHPEVQMGFHPDAGASyylSRLPGYLGEYLA----LTGQKLNGVEMIACGLAT 220


                  .
gi 1907156589  78 H 78
Cdd:PLN02851  221 H 221
PRK12478 PRK12478
crotonase/enoyl-CoA hydratase family protein;
3-80 2.15e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 183548  Cd Length: 298  Bit Score: 46.10  E-value: 2.15e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGlieTTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PRK12478  121 GWCVGGASDYALCADIVIASDDAVIG---TPYSRMWGAYLTGMWLYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAV 195
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 3-156 2.70e-06

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 45.57  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQ 82
Cdd:PRK05674  110 GAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAP-AVISPFVVKAIGERAARRYALTAERFDGRRARELGLLAESYPA 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  83 NEegnaAYHRALALAQEILPQAPIAVRLGKvaiDRGMEVDIAS-GMAIEQmcYAQNIPTQDRL-----EGMAAFREKRAP 156
Cdd:PRK05674  189 AE----LEAQVEAWIANLLLNSPQALRASK---DLLREVGDGElSPALRR--YCENAIARIRVsaegqEGLRAFLEKRTP 259
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 1-80 4.59e-06

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 45.09  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVaLAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PLN02988  112 LNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGF-FGEYVGLTGARLDGAEMLACGLATHFV 190
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 8-109 5.99e-06

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 44.87  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   8 GGLELALACDLRIAASSAVMGLIETTRGL-LPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQneeg 86
Cdd:PLN03214  121 GGCAVSLCCDYRLQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAESLLLRGRLVRPAEAKQLGLIDEVVPA---- 196

                          90       100
                  ....*....|....*....|...
gi 1907156589  87 nAAYHRALALAQEILPQAPIAVR 109
Cdd:PLN03214  197 -AALMEAAASAMERALKLPSAAR 218
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
1-160 3.25e-05

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 42.36  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIfTGRRLNGAQARELGLVNHAV 80
Cdd:PRK07827  108 IDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAPAIISLTLLPRLSPRAAARYYL-TGEKFGAAEAARIGLVTAAA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589  81 AQNEEGNAAYHRALALAQeilPQAPIAV-RLGKVAIDRGMEVDiASGMAIEQmcyAQNIPTQDRLEGMAAFREKRAPKFV 159
Cdd:PRK07827  187 DDVDAAVAALLADLRRGS---PQGLAESkALTTAAVLAGFDRD-AEELTEES---ARLFVSDEAREGMTAFLQKRPPRWA 259


                  .
gi 1907156589 160 G 160
Cdd:PRK07827  260 L 260
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 2-76 3.80e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 42.42  E-value: 3.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907156589   2 DGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLV 76
Cdd:PRK07260  106 DGAVAGAAANMAVAADFCIASTKTKFIQAFVGVGLAPDAGGLFLLTRAIGLNRATHLAMTGEALTAEKALEYGFV 180
PLN02157 PLN02157
3-hydroxyisobutyryl-CoA hydrolase-like protein
 1-84 6.98e-05

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 177817 [Multi-domain]  Cd Length: 401  Bit Score: 41.98  E-value: 6.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156589   1 MDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PLN02157  140 LNGVTMGGGTGVSIPGTFRVATDRTIFATPETIIGFHPDAGASFNLSHLPG-RLGEYLGLTGLKLSGAEMLACGLATHYI 218


                  ....
gi 1907156589  81 AQNE 84
Cdd:PLN02157  219 RSEE 222
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 3-80 4.86e-03

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 36.32  E-value: 4.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907156589   3 GFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELIFTGRRLNGAQARELGLVNHAV 80
Cdd:PLN02874  114 GLVMGGGAGLMVPMKFRVVTEKTVFATPEASVGFHTDCGFSYILSRLPG-HLGEYLALTGARLNGKEMVACGLATHFV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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