View
Concise Results
Standard Results
Full Results
DIS3-like exonuclease 2 isoform X6 [Mus musculus]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
VacB super family
cl43181 Exoribonuclease R [Transcription];
18-547
2.36e-124
Exoribonuclease R [Transcription];
COG0557 :Pssm-ID: 440323 [Multi-domain]
Cd Length: 711
Bit Score: 385.23
E-value: 2.36e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 18 PIPQ D T RG LS E kslqks AK VV Y ILE KKHS R A a T G ILKLL adknsdlf K KYALFS P S D H R VPR - I YV P LK D CPQ dfmtr P K 96
Cdd:COG0557 113 VTKE D R RG RP E ------ GR VV E ILE RANT R V - V G RFEKE -------- K GFGFVV P D D K R LLQ d I FI P PD D LNG ----- A K 172
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 97 D fa NT L FICR I IDWK E DCNFAL G QLAKS LG QA G EIEP E TEGILTEY G VDF s D F SS EVL ECL p QS LP WTI P PDEVGK RRDL 176
Cdd:COG0557 173 D -- GD L VVVE I TRYP E RRGPPE G RVVEV LG SP G DPGA E ILIAIRKH G LPH - E F PE EVL AEA - EA LP DEV P EADLKG RRDL 248
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 177 R KDCIF TID PST A R D L DDA LACRR L TD G TFEV GVHIADVS YF V PE GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CEE LCS 256
Cdd:COG0557 249 R DLPLV TID GED A K D F DDA VSAEK L DN G GWRL GVHIADVS HY V RP GS A LD RE A RK R G TSVYL PDR V I PMLP ER L SNG LCS 328
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 257 LNP MT D K L TF S VIWKLTPE G KILEEW F G R TI IRS CTK L S Y DHA Q SMIENPT E KIP EE E lppispehsv EEVHQAVLN L HS 336
Cdd:COG0557 329 LNP GE D R L AM S CEMEIDAK G EVVSYE F Y R SV IRS DAR L T Y EEV Q AILDGKD E ELR EE Y ---------- ADLVPMLEE L YE 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 337 I AK Q LR RQ R FVD GA LRL D QLKLAFT LD h E T G L P QGCHIY E YR D SN KL V EEFMLLAN M AVA HKIFRT fp EQAL L R R - H PP P 415
Cdd:COG0557 399 L AK I LR KA R EKR GA IDF D LPETKII LD - E E G K P EDIVPR E RN D AH KL I EEFMLLAN E AVA EFLEKL -- KLPF L Y R v H EE P 475
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 416 QTKM L SD L V EF CDQM GL PM --- D VSSAGA L N K s L TKTFGDDKYS lark E V L TNMYS R P M QM A L Y fcsgmlq DQ E QFR H YA 492
Cdd:COG0557 476 DPEK L EA L R EF LANL GL KL kgg D EPTPKD L Q K - L LEQVKGRPEE ---- E L L NTLLL R S M KQ A V Y ------- SP E NIG H FG 543
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067957 493 L NVPL YTHFTSPIRR FA D VI VHR L L A A A L G --- YSEQPDVEPDT L QKQ A D HC NDR - R M A 547
Cdd:COG0557 544 L ALEA YTHFTSPIRR YP D LL VHR A L K A Y L E gkr SPGLQEYLEEE L EEI A E HC SET e R R A 602
Dis3l2_C_term
pfam17877 DIS3-like exonuclease 2 C terminal; This is the C-terminal S1 domain found in Dis3L2 proteins. ...
568-657
2.85e-31
DIS3-like exonuclease 2 C terminal; This is the C-terminal S1 domain found in Dis3L2 proteins. Dis3L2 belongs to the RNase II/R 3-5 exonuclease superfamily, which includes the catalytic subunit of the RNA exosome in yeast and in humans.
Pssm-ID: 465547
Cd Length: 87
Bit Score: 116.98
E-value: 2.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 568 GPLE S EA M V M GVL NQA FDVL VLRF G VQ KR I Y CNA L A L RSYS F Q K V G K kpe LTL V W EPDDLEEEPTQQVITIF SLV D VVL Q 647
Cdd:pfam17877 1 GPLE T EA V V L GVL DSS FDVL IPEY G IE KR V Y LDQ L P L KKFE F D K T G V --- LTL Y W KKGVPSSAYVPEDERFS SLV V VVL K 77
90
....*....|
gi 1907067957 648 AEATA LK YS A 657
Cdd:pfam17877 78 SDSDP LK LE A 87
Name
Accession
Description
Interval
E-value
VacB
COG0557 Exoribonuclease R [Transcription];
18-547
2.36e-124
Exoribonuclease R [Transcription];
Pssm-ID: 440323 [Multi-domain]
Cd Length: 711
Bit Score: 385.23
E-value: 2.36e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 18 PIPQ D T RG LS E kslqks AK VV Y ILE KKHS R A a T G ILKLL adknsdlf K KYALFS P S D H R VPR - I YV P LK D CPQ dfmtr P K 96
Cdd:COG0557 113 VTKE D R RG RP E ------ GR VV E ILE RANT R V - V G RFEKE -------- K GFGFVV P D D K R LLQ d I FI P PD D LNG ----- A K 172
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 97 D fa NT L FICR I IDWK E DCNFAL G QLAKS LG QA G EIEP E TEGILTEY G VDF s D F SS EVL ECL p QS LP WTI P PDEVGK RRDL 176
Cdd:COG0557 173 D -- GD L VVVE I TRYP E RRGPPE G RVVEV LG SP G DPGA E ILIAIRKH G LPH - E F PE EVL AEA - EA LP DEV P EADLKG RRDL 248
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 177 R KDCIF TID PST A R D L DDA LACRR L TD G TFEV GVHIADVS YF V PE GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CEE LCS 256
Cdd:COG0557 249 R DLPLV TID GED A K D F DDA VSAEK L DN G GWRL GVHIADVS HY V RP GS A LD RE A RK R G TSVYL PDR V I PMLP ER L SNG LCS 328
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 257 LNP MT D K L TF S VIWKLTPE G KILEEW F G R TI IRS CTK L S Y DHA Q SMIENPT E KIP EE E lppispehsv EEVHQAVLN L HS 336
Cdd:COG0557 329 LNP GE D R L AM S CEMEIDAK G EVVSYE F Y R SV IRS DAR L T Y EEV Q AILDGKD E ELR EE Y ---------- ADLVPMLEE L YE 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 337 I AK Q LR RQ R FVD GA LRL D QLKLAFT LD h E T G L P QGCHIY E YR D SN KL V EEFMLLAN M AVA HKIFRT fp EQAL L R R - H PP P 415
Cdd:COG0557 399 L AK I LR KA R EKR GA IDF D LPETKII LD - E E G K P EDIVPR E RN D AH KL I EEFMLLAN E AVA EFLEKL -- KLPF L Y R v H EE P 475
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 416 QTKM L SD L V EF CDQM GL PM --- D VSSAGA L N K s L TKTFGDDKYS lark E V L TNMYS R P M QM A L Y fcsgmlq DQ E QFR H YA 492
Cdd:COG0557 476 DPEK L EA L R EF LANL GL KL kgg D EPTPKD L Q K - L LEQVKGRPEE ---- E L L NTLLL R S M KQ A V Y ------- SP E NIG H FG 543
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067957 493 L NVPL YTHFTSPIRR FA D VI VHR L L A A A L G --- YSEQPDVEPDT L QKQ A D HC NDR - R M A 547
Cdd:COG0557 544 L ALEA YTHFTSPIRR YP D LL VHR A L K A Y L E gkr SPGLQEYLEEE L EEI A E HC SET e R R A 602
RNB
pfam00773 RNB domain; This domain is the catalytic domain of ribonuclease II.
173-521
5.34e-115
RNB domain; This domain is the catalytic domain of ribonuclease II.
Pssm-ID: 459934 [Multi-domain]
Cd Length: 314
Bit Score: 347.35
E-value: 5.34e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 173 R R DLR KDCIF TIDP ST A R DLDDA LACRR L TD G TFEV GVHIADVS YF VP E GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CE 252
Cdd:pfam00773 1 R K DLR DLPFI TIDP AD A K DLDDA ISVEK L PN G GYRL GVHIADVS HY VP P GS P LD RE A RK R G TSVYL PDR V I PMLP EK L SN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 253 E LCSLNP MT D K L TF SV IWKLTPE G KILEEWFGRTI IRS CTK L S Y DHAQSMI E NPTEKIPEEE L ppispehsveev HQAVL 332
Cdd:pfam00773 81 D LCSLNP GE D R L AL SV EITIDAD G EVTSYEIYPSV IRS KAR L T Y EEVDDLL E GKDAEKDKPD L ------------ AEDLR 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 333 N L HSI AK Q LR RQ R FVD GAL R LD QLKLAFT LD H E T gl PQGCH I Y E YR D SNK L V EEFMLLAN M AVA HKI f RTFPEQ AL L R R H 412
Cdd:pfam00773 149 L L YEL AK I LR AK R LQR GAL D LD TPENKLI LD E E G -- VIDIL I Q E RT D AHS L I EEFMLLAN E AVA RHL - QELGIP AL Y R V H 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 413 P P P QTKM L SD L VEFCDQMGLPM dvssag A L N KSL T K TFG D dkyslar KEV L TNMYS R P M QM A L Y F csgmlqd Q E QFR H YA 492
Cdd:pfam00773 226 P E P DLEK L NS L IKLLQLLPDDK ------ G L S KSL E K IKD D ------- ERL L SILLL R T M PR A E Y S ------- P E PLG H FG 285
330 340
....*....|....*....|....*....
gi 1907067957 493 L NVPL YTHFTSPIRR FA D V IVHR L L A A A L 521
Cdd:pfam00773 286 L GLDI YTHFTSPIRR YP D L IVHR Q L K A L L 314
RNB
smart00955 This domain is the catalytic domain of ribonuclease II;
173-522
3.65e-106
This domain is the catalytic domain of ribonuclease II;
Pssm-ID: 214935 [Multi-domain]
Cd Length: 286
Bit Score: 323.84
E-value: 3.65e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 173 R R DLR KDCI FTIDP ST A R D L DDA LACRR L TD G TFEV GVHIADVS YF V PE GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CE 252
Cdd:smart00955 1 R V DLR DLPL FTIDP ED A K D I DDA VSVEK L DN G GYRL GVHIADVS HY V KP GS A LD RE A RK R G TSVYL PDR V I PMLP EE L SN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 253 E LCSLNP MT D K L TF SV IWK L TPE G - K IL EEW F G R TI IRS CTK L S Y DHAQSMI E N ptekipeeelppispehsveevhqav 331
Cdd:smart00955 81 G LCSLNP GE D R L AL SV EMT L DAD G g E IL DYE F Y R SV IRS KAR L T Y EEVDAIL E K -------------------------- 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 332 lnlhsiakqlrrqrfvdgalrldqlkla FT LD H E t G LPQGCHIY E YR D SNK LVEEFM L LAN M AVA HKIFRTFP e QA L L R R 411
Cdd:smart00955 135 ---------------------------- IV LD E E - G KIEDIVPR E RN D AHS LVEEFM I LAN E AVA RFLAKNGI - PG L Y R V 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 412 H PP P QTKM L SD - L V EF CDQM GL PM - DVSSAG AL N K S L T K TFGDDK yslar KEV L TNMYS R P M QM A L Y FCSG mlqdqeq FR 489
Cdd:smart00955 185 H EG P DPEK L AE l L K EF LALL GL LL l GGDGPK AL A K L L E K IRDSPE ----- ERL L ELLLL R S M PH A E Y SVDN ------- SG 252
330 340 350
....*....|....*....|....*....|...
gi 1907067957 490 H YA L NVPL YTHFTSPIRR FA D V IVHR L L A AAL G 522
Cdd:smart00955 253 H FG L ALDA YTHFTSPIRR YP D L IVHR Q L K AAL R 285
RNase_R
TIGR02063 ribonuclease R; This family consists of an exoribonuclease, ribonuclease R, also called VacB. ...
33-544
5.56e-99
ribonuclease R; This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA]
Pssm-ID: 273947 [Multi-domain]
Cd Length: 709
Bit Score: 318.83
E-value: 5.56e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 33 KS A K V VY ILE KKHSRAATGILKL ladknsdlf KKYALFS P S D H R VP - R I YV P LKDC pqdfm TRPKD fa NTLFICR I IDWK 111
Cdd:TIGR02063 123 FE A R V IK ILE RANDQIVGTFYIE --------- NGIGFVI P D D K R IY l D I FI P PEQI ----- LGAEE -- GDKVLVE I TKYP 186
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 112 EDCNF A L G QLAKS LG Q A GEIEPETEG I LTEY G VDF s D F SS EVL E c LPQSL P WTI P PD E VGK R R DLR KDCIF TID PST A R D 191
Cdd:TIGR02063 187 DRNRP A I G KVVEI LG H A DDPGIDILI I IRKH G IPY - E F PE EVL D - EAAKI P EEV P EE E IKG R K DLR DLPFV TID GED A K D 264
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 192 L DDA LACRR L T DG TFEV GV H IADVS YF V P EGS S LDK V A AE R A TSVYL VQK V V PMLP RL L CEEL CSLNP MT D K LT F S VIWK 271
Cdd:TIGR02063 265 F DDA VYVEK L K DG NYKL GV A IADVS HY V R EGS A LDK E A LK R G TSVYL PDR V I PMLP ER L SNGI CSLNP NE D R LT L S CEME 344
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 272 LTPE G KILEEW F GRTI I R S CTK L S Y DHAQSM IE N pt EKIPEEEL PP ISPE hsveevhqa VL NL HSIA K Q LR RQ R FVD GA L 351
Cdd:TIGR02063 345 IDKK G RVKKYE F YEAV I N S HAR L T Y NQVNDI IE G -- KDALDKKE PP LKEM --------- LK NL FELY K I LR KK R KKR GA I 413
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 352 RL D QLKLAFT LD h E T G L P QGCHIY E YR D SN KL V EEFM LL AN MA VA HKIFRT f PEQALL R R H PP P QTKM L SD L V EF CDQM G 431
Cdd:TIGR02063 414 DF D SKEAKII LD - E N G K P IDIVPR E RG D AH KL I EEFM IA AN ET VA EHLEKA - KLPFIY R V H ER P SEEK L QN L R EF LKTL G 491
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 432 LPMDVSSA ----- GALN K S L T K TF G DDKYS L ARKEV L tnmys R P MQ M A L Y fcsgmlq DQ E QFR H YA L NVPL YTHFTSPIR 506
Cdd:TIGR02063 492 ITLKGGTS dkpqp KDFQ K L L E K VK G RPEEE L INTVL L ----- R S MQ Q A K Y ------- SP E NIG H FG L ALEY YTHFTSPIR 559
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1907067957 507 R FA D V IVHRL LAA AL G ------ YSEQPDVEPDT L QKQ A D H CNDR 544
Cdd:TIGR02063 560 R YP D L IVHRL IKK AL F ggentt TEKEREYLEAK L EEI A E H SSKT 603
PRK11642
PRK11642 ribonuclease R;
167-525
2.64e-41
ribonuclease R;
Pssm-ID: 236944 [Multi-domain]
Cd Length: 813
Bit Score: 161.06
E-value: 2.64e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 167 P D E VGKR R - DLR KDCIF TID PST ARD L DDA LA C RRLTD G TFEVG V H IADVSY F V PEGSS LD KV A AE R A TSVY LVQK VVPM 245
Cdd:PRK11642 253 P E E AKAG R v DLR DLPLV TID GED ARD F DDA VY C EKKRG G GWRLW V A IADVSY Y V RPPTP LD RE A RN R G TSVY FPSQ VVPM 332
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 246 LP RL L CEE LCSLNP MT D K L TFSVIWKLTPE G KILEEW F GRTIIR S CTK L S Y DHAQSMIEN p TEKIP E EEL P PISP ehs V E 325
Cdd:PRK11642 333 LP EV L SNG LCSLNP QV D R L CMVCEMTISSK G RLTGYK F YEAVMS S HAR L T Y TKVWHILQG - DQDLR E QYA P LVKH --- L E 408
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 326 E V H qavl NL HSIAKQL R RQ R fvd G ALRLDQLKLA F TLDH E TGLPQ g CHIYEYR D SN KL V EE F M L LAN MAV A h KIFRTFP E 405
Cdd:PRK11642 409 E L H ---- NL YKVLDKA R EE R --- G GISFESEEAK F IFNA E RRIER - IEQTQRN D AH KL I EE C M I LAN ISA A - RFVEKAK E 479
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 406 Q AL L R R H PP P Q T KMLSDLVEFCDQM GL pmdvs SAGAL NK SLTKTFGDDKY S L A RK --- E V L TN M YS R P M QM A L Y fcsgml 482
Cdd:PRK11642 480 P AL F R I H DK P S T EAITSFRSVLAEL GL ----- ELPGG NK PEPRDYAELLE S V A DR pda E M L QT M LL R S M KQ A I Y ------ 548
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1907067957 483 q D Q E QFR H YA L NVPL Y T HFTSPIRR FA D VIV HR ---- LLA AAL G YSE 525
Cdd:PRK11642 549 - D P E NRG H FG L ALQS Y A HFTSPIRR YP D LSL HR aiky LLA KEQ G HKG 594
Dis3l2_C_term
pfam17877 DIS3-like exonuclease 2 C terminal; This is the C-terminal S1 domain found in Dis3L2 proteins. ...
568-657
2.85e-31
DIS3-like exonuclease 2 C terminal; This is the C-terminal S1 domain found in Dis3L2 proteins. Dis3L2 belongs to the RNase II/R 3-5 exonuclease superfamily, which includes the catalytic subunit of the RNA exosome in yeast and in humans.
Pssm-ID: 465547
Cd Length: 87
Bit Score: 116.98
E-value: 2.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 568 GPLE S EA M V M GVL NQA FDVL VLRF G VQ KR I Y CNA L A L RSYS F Q K V G K kpe LTL V W EPDDLEEEPTQQVITIF SLV D VVL Q 647
Cdd:pfam17877 1 GPLE T EA V V L GVL DSS FDVL IPEY G IE KR V Y LDQ L P L KKFE F D K T G V --- LTL Y W KKGVPSSAYVPEDERFS SLV V VVL K 77
90
....*....|
gi 1907067957 648 AEATA LK YS A 657
Cdd:pfam17877 78 SDSDP LK LE A 87
Name
Accession
Description
Interval
E-value
VacB
COG0557 Exoribonuclease R [Transcription];
18-547
2.36e-124
Exoribonuclease R [Transcription];
Pssm-ID: 440323 [Multi-domain]
Cd Length: 711
Bit Score: 385.23
E-value: 2.36e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 18 PIPQ D T RG LS E kslqks AK VV Y ILE KKHS R A a T G ILKLL adknsdlf K KYALFS P S D H R VPR - I YV P LK D CPQ dfmtr P K 96
Cdd:COG0557 113 VTKE D R RG RP E ------ GR VV E ILE RANT R V - V G RFEKE -------- K GFGFVV P D D K R LLQ d I FI P PD D LNG ----- A K 172
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 97 D fa NT L FICR I IDWK E DCNFAL G QLAKS LG QA G EIEP E TEGILTEY G VDF s D F SS EVL ECL p QS LP WTI P PDEVGK RRDL 176
Cdd:COG0557 173 D -- GD L VVVE I TRYP E RRGPPE G RVVEV LG SP G DPGA E ILIAIRKH G LPH - E F PE EVL AEA - EA LP DEV P EADLKG RRDL 248
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 177 R KDCIF TID PST A R D L DDA LACRR L TD G TFEV GVHIADVS YF V PE GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CEE LCS 256
Cdd:COG0557 249 R DLPLV TID GED A K D F DDA VSAEK L DN G GWRL GVHIADVS HY V RP GS A LD RE A RK R G TSVYL PDR V I PMLP ER L SNG LCS 328
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 257 LNP MT D K L TF S VIWKLTPE G KILEEW F G R TI IRS CTK L S Y DHA Q SMIENPT E KIP EE E lppispehsv EEVHQAVLN L HS 336
Cdd:COG0557 329 LNP GE D R L AM S CEMEIDAK G EVVSYE F Y R SV IRS DAR L T Y EEV Q AILDGKD E ELR EE Y ---------- ADLVPMLEE L YE 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 337 I AK Q LR RQ R FVD GA LRL D QLKLAFT LD h E T G L P QGCHIY E YR D SN KL V EEFMLLAN M AVA HKIFRT fp EQAL L R R - H PP P 415
Cdd:COG0557 399 L AK I LR KA R EKR GA IDF D LPETKII LD - E E G K P EDIVPR E RN D AH KL I EEFMLLAN E AVA EFLEKL -- KLPF L Y R v H EE P 475
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 416 QTKM L SD L V EF CDQM GL PM --- D VSSAGA L N K s L TKTFGDDKYS lark E V L TNMYS R P M QM A L Y fcsgmlq DQ E QFR H YA 492
Cdd:COG0557 476 DPEK L EA L R EF LANL GL KL kgg D EPTPKD L Q K - L LEQVKGRPEE ---- E L L NTLLL R S M KQ A V Y ------- SP E NIG H FG 543
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067957 493 L NVPL YTHFTSPIRR FA D VI VHR L L A A A L G --- YSEQPDVEPDT L QKQ A D HC NDR - R M A 547
Cdd:COG0557 544 L ALEA YTHFTSPIRR YP D LL VHR A L K A Y L E gkr SPGLQEYLEEE L EEI A E HC SET e R R A 602
RNB
pfam00773 RNB domain; This domain is the catalytic domain of ribonuclease II.
173-521
5.34e-115
RNB domain; This domain is the catalytic domain of ribonuclease II.
Pssm-ID: 459934 [Multi-domain]
Cd Length: 314
Bit Score: 347.35
E-value: 5.34e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 173 R R DLR KDCIF TIDP ST A R DLDDA LACRR L TD G TFEV GVHIADVS YF VP E GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CE 252
Cdd:pfam00773 1 R K DLR DLPFI TIDP AD A K DLDDA ISVEK L PN G GYRL GVHIADVS HY VP P GS P LD RE A RK R G TSVYL PDR V I PMLP EK L SN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 253 E LCSLNP MT D K L TF SV IWKLTPE G KILEEWFGRTI IRS CTK L S Y DHAQSMI E NPTEKIPEEE L ppispehsveev HQAVL 332
Cdd:pfam00773 81 D LCSLNP GE D R L AL SV EITIDAD G EVTSYEIYPSV IRS KAR L T Y EEVDDLL E GKDAEKDKPD L ------------ AEDLR 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 333 N L HSI AK Q LR RQ R FVD GAL R LD QLKLAFT LD H E T gl PQGCH I Y E YR D SNK L V EEFMLLAN M AVA HKI f RTFPEQ AL L R R H 412
Cdd:pfam00773 149 L L YEL AK I LR AK R LQR GAL D LD TPENKLI LD E E G -- VIDIL I Q E RT D AHS L I EEFMLLAN E AVA RHL - QELGIP AL Y R V H 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 413 P P P QTKM L SD L VEFCDQMGLPM dvssag A L N KSL T K TFG D dkyslar KEV L TNMYS R P M QM A L Y F csgmlqd Q E QFR H YA 492
Cdd:pfam00773 226 P E P DLEK L NS L IKLLQLLPDDK ------ G L S KSL E K IKD D ------- ERL L SILLL R T M PR A E Y S ------- P E PLG H FG 285
330 340
....*....|....*....|....*....
gi 1907067957 493 L NVPL YTHFTSPIRR FA D V IVHR L L A A A L 521
Cdd:pfam00773 286 L GLDI YTHFTSPIRR YP D L IVHR Q L K A L L 314
RNB
smart00955 This domain is the catalytic domain of ribonuclease II;
173-522
3.65e-106
This domain is the catalytic domain of ribonuclease II;
Pssm-ID: 214935 [Multi-domain]
Cd Length: 286
Bit Score: 323.84
E-value: 3.65e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 173 R R DLR KDCI FTIDP ST A R D L DDA LACRR L TD G TFEV GVHIADVS YF V PE GS S LD KV A AE R A TSVYL VQK V V PMLP RL L CE 252
Cdd:smart00955 1 R V DLR DLPL FTIDP ED A K D I DDA VSVEK L DN G GYRL GVHIADVS HY V KP GS A LD RE A RK R G TSVYL PDR V I PMLP EE L SN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 253 E LCSLNP MT D K L TF SV IWK L TPE G - K IL EEW F G R TI IRS CTK L S Y DHAQSMI E N ptekipeeelppispehsveevhqav 331
Cdd:smart00955 81 G LCSLNP GE D R L AL SV EMT L DAD G g E IL DYE F Y R SV IRS KAR L T Y EEVDAIL E K -------------------------- 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 332 lnlhsiakqlrrqrfvdgalrldqlkla FT LD H E t G LPQGCHIY E YR D SNK LVEEFM L LAN M AVA HKIFRTFP e QA L L R R 411
Cdd:smart00955 135 ---------------------------- IV LD E E - G KIEDIVPR E RN D AHS LVEEFM I LAN E AVA RFLAKNGI - PG L Y R V 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 412 H PP P QTKM L SD - L V EF CDQM GL PM - DVSSAG AL N K S L T K TFGDDK yslar KEV L TNMYS R P M QM A L Y FCSG mlqdqeq FR 489
Cdd:smart00955 185 H EG P DPEK L AE l L K EF LALL GL LL l GGDGPK AL A K L L E K IRDSPE ----- ERL L ELLLL R S M PH A E Y SVDN ------- SG 252
330 340 350
....*....|....*....|....*....|...
gi 1907067957 490 H YA L NVPL YTHFTSPIRR FA D V IVHR L L A AAL G 522
Cdd:smart00955 253 H FG L ALDA YTHFTSPIRR YP D L IVHR Q L K AAL R 285
RNase_R
TIGR02063 ribonuclease R; This family consists of an exoribonuclease, ribonuclease R, also called VacB. ...
33-544
5.56e-99
ribonuclease R; This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA]
Pssm-ID: 273947 [Multi-domain]
Cd Length: 709
Bit Score: 318.83
E-value: 5.56e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 33 KS A K V VY ILE KKHSRAATGILKL ladknsdlf KKYALFS P S D H R VP - R I YV P LKDC pqdfm TRPKD fa NTLFICR I IDWK 111
Cdd:TIGR02063 123 FE A R V IK ILE RANDQIVGTFYIE --------- NGIGFVI P D D K R IY l D I FI P PEQI ----- LGAEE -- GDKVLVE I TKYP 186
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 112 EDCNF A L G QLAKS LG Q A GEIEPETEG I LTEY G VDF s D F SS EVL E c LPQSL P WTI P PD E VGK R R DLR KDCIF TID PST A R D 191
Cdd:TIGR02063 187 DRNRP A I G KVVEI LG H A DDPGIDILI I IRKH G IPY - E F PE EVL D - EAAKI P EEV P EE E IKG R K DLR DLPFV TID GED A K D 264
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 192 L DDA LACRR L T DG TFEV GV H IADVS YF V P EGS S LDK V A AE R A TSVYL VQK V V PMLP RL L CEEL CSLNP MT D K LT F S VIWK 271
Cdd:TIGR02063 265 F DDA VYVEK L K DG NYKL GV A IADVS HY V R EGS A LDK E A LK R G TSVYL PDR V I PMLP ER L SNGI CSLNP NE D R LT L S CEME 344
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 272 LTPE G KILEEW F GRTI I R S CTK L S Y DHAQSM IE N pt EKIPEEEL PP ISPE hsveevhqa VL NL HSIA K Q LR RQ R FVD GA L 351
Cdd:TIGR02063 345 IDKK G RVKKYE F YEAV I N S HAR L T Y NQVNDI IE G -- KDALDKKE PP LKEM --------- LK NL FELY K I LR KK R KKR GA I 413
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 352 RL D QLKLAFT LD h E T G L P QGCHIY E YR D SN KL V EEFM LL AN MA VA HKIFRT f PEQALL R R H PP P QTKM L SD L V EF CDQM G 431
Cdd:TIGR02063 414 DF D SKEAKII LD - E N G K P IDIVPR E RG D AH KL I EEFM IA AN ET VA EHLEKA - KLPFIY R V H ER P SEEK L QN L R EF LKTL G 491
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 432 LPMDVSSA ----- GALN K S L T K TF G DDKYS L ARKEV L tnmys R P MQ M A L Y fcsgmlq DQ E QFR H YA L NVPL YTHFTSPIR 506
Cdd:TIGR02063 492 ITLKGGTS dkpqp KDFQ K L L E K VK G RPEEE L INTVL L ----- R S MQ Q A K Y ------- SP E NIG H FG L ALEY YTHFTSPIR 559
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1907067957 507 R FA D V IVHRL LAA AL G ------ YSEQPDVEPDT L QKQ A D H CNDR 544
Cdd:TIGR02063 560 R YP D L IVHRL IKK AL F ggentt TEKEREYLEAK L EEI A E H SSKT 603
3_prime_RNase
TIGR00358 VacB and RNase II family 3'-5' exoribonucleases; This model is defined to identify a pair of ...
17-545
8.28e-69
VacB and RNase II family 3'-5' exoribonucleases; This model is defined to identify a pair of paralogous 3-prime exoribonucleases in E. coli, plus the set of proteins apparently orthologous to one or the other in other eubacteria. VacB was characterized originally as required for the expression of virulence genes, but is now recognized as the exoribonuclease RNase R (Rnr). Its paralog in E. coli and H. influenzae is designated exoribonuclease II (Rnb). Both are involved in the degradation of mRNA, and consequently have strong pleiotropic effects that may be difficult to disentangle. Both these proteins share domain-level similarity (RNB, S1) with a considerable number of other proteins, and full-length similarity scoring below the trusted cutoff to proteins associated with various phenotypes but uncertain biochemistry; it may be that these latter proteins are also 3-prime exoribonucleases. [Transcription, Degradation of RNA]
Pssm-ID: 273033 [Multi-domain]
Cd Length: 654
Bit Score: 236.92
E-value: 8.28e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 17 T P IP Q DT RG lseksl QKS A K V VY ILE KKHS R AATGI L klladknsdl FKKYAL F SPS D H rv PRIY VPLK d C P QD fm TRPK 96
Cdd:TIGR00358 60 C P LS Q PQ RG ------ RFE A E V ER ILE PALT R FVGKF L ---------- GENDFG F VVP D D -- PRIY LDII - V P KA -- SVKN 118
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 97 DF A - NTLFICRIIDWKEDC N FAL G QLAKS LG QAGEIEPETEGI L TEYGVD F SD fs SEVL E CLPQS L PWTIPPDEVGK R R D 175
Cdd:TIGR00358 119 EL A e GDKVVVELTEYPLRR N LFY G EITQI LG NNDDPLIPWWVT L ARHEIP F EF -- PDGV E QQAAK L QFDVDEQAKKY R E D 196
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 176 L RKDCIF TID PST A R DLDDA LACRR L T DG TFEVG V H IADVSY F V P E G S S LDK V A AE R AT SVYL VQK V V PMLP RL L CEE LC 255
Cdd:TIGR00358 197 L TDLAFV TID GAD A K DLDDA VYVKK L P DG GWKLY V A IADVSY Y V A E N S P LDK E A KH R GF SVYL PGF V I PMLP EE L SNG LC 276
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 256 SLNP MT D K L TFSVIWKLTPE G K I LEEW F GRTI I R S CTK L S YD HAQSMI EN ptekip EE EL P P ISPE h S VE EVHQ avln LH 335
Cdd:TIGR00358 277 SLNP NE D R L VLVCEMTISAQ G R I TDNE F YPAT I E S KAR L T YD KVNDWL EN ------ DD EL Q P EYET - L VE QLKA ---- LH 345
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 336 SIAKQ L RRQ R FVD G ALRLDQLKLA F TL D h E T G LPQGCHIYEY R DSN K LV EE F M LL AN MAV A h KIFRTFPEQALL R R HP P P 415
Cdd:TIGR00358 346 QLSQA L GEW R HKR G LIDFEHPETK F IV D - E E G RVIDIVAEVR R IAE K II EE A M IV AN ICA A - RFLHNHKVPGIY R V HP G P 423
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 416 QT K M L SD L V EF CDQM GL PMDVSS A GALNKS ltktfgd D KYSLA R K ------- E V L TNMYS R PMQM A L Y fcsgmlq DQ E QF 488
Cdd:TIGR00358 424 SK K K L QS L L EF LAEL GL TLPGGN A ENVTTL ------- D GACWL R E vkdrpey E I L VTRLL R SLSQ A E Y ------- SP E PL 489
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907067957 489 R H YA L NVPL Y T HFTSPIRR FA D VIV HRL LA A A L g YS EQ P D V E PDTL Q ---- KQ A D HC N D RR 545
Cdd:TIGR00358 490 G H FG L GLEH Y A HFTSPIRR YP D LTN HRL IK A V L - AK EQ T D T E RYQP Q dell QI A E HC S D TE 549
PRK11642
PRK11642 ribonuclease R;
167-525
2.64e-41
ribonuclease R;
Pssm-ID: 236944 [Multi-domain]
Cd Length: 813
Bit Score: 161.06
E-value: 2.64e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 167 P D E VGKR R - DLR KDCIF TID PST ARD L DDA LA C RRLTD G TFEVG V H IADVSY F V PEGSS LD KV A AE R A TSVY LVQK VVPM 245
Cdd:PRK11642 253 P E E AKAG R v DLR DLPLV TID GED ARD F DDA VY C EKKRG G GWRLW V A IADVSY Y V RPPTP LD RE A RN R G TSVY FPSQ VVPM 332
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 246 LP RL L CEE LCSLNP MT D K L TFSVIWKLTPE G KILEEW F GRTIIR S CTK L S Y DHAQSMIEN p TEKIP E EEL P PISP ehs V E 325
Cdd:PRK11642 333 LP EV L SNG LCSLNP QV D R L CMVCEMTISSK G RLTGYK F YEAVMS S HAR L T Y TKVWHILQG - DQDLR E QYA P LVKH --- L E 408
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 326 E V H qavl NL HSIAKQL R RQ R fvd G ALRLDQLKLA F TLDH E TGLPQ g CHIYEYR D SN KL V EE F M L LAN MAV A h KIFRTFP E 405
Cdd:PRK11642 409 E L H ---- NL YKVLDKA R EE R --- G GISFESEEAK F IFNA E RRIER - IEQTQRN D AH KL I EE C M I LAN ISA A - RFVEKAK E 479
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 406 Q AL L R R H PP P Q T KMLSDLVEFCDQM GL pmdvs SAGAL NK SLTKTFGDDKY S L A RK --- E V L TN M YS R P M QM A L Y fcsgml 482
Cdd:PRK11642 480 P AL F R I H DK P S T EAITSFRSVLAEL GL ----- ELPGG NK PEPRDYAELLE S V A DR pda E M L QT M LL R S M KQ A I Y ------ 548
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1907067957 483 q D Q E QFR H YA L NVPL Y T HFTSPIRR FA D VIV HR ---- LLA AAL G YSE 525
Cdd:PRK11642 549 - D P E NRG H FG L ALQS Y A HFTSPIRR YP D LSL HR aiky LLA KEQ G HKG 594
Rnb
COG4776 Exoribonuclease II [Transcription];
162-547
2.93e-36
Exoribonuclease II [Transcription];
Pssm-ID: 443808 [Multi-domain]
Cd Length: 644
Bit Score: 144.61
E-value: 2.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 162 P W TIP p DE VGK R R DL RKDCIF TID PSTAR D L DDAL ACRR L TD G TFEVG V H IAD VSYFV PEGS S LDK V A AE RA TSV YL VQK 241
Cdd:COG4776 180 E W ELL - DE GLE R E DL TALPFV TID SESTE D M DDAL YIEK L EN G GWKLT V A IAD PTAYI PEGS E LDK E A RQ RA FTN YL PGF 258
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 242 VV PMLPR L L CEE LCSL NPMTDKLTFSVIWKLTPE G K I LE -- E W F GRT i IRS CT KL S YD HAQSMI E NPT E KI PE E elppis 319
Cdd:COG4776 259 NI PMLPR E L SDD LCSL KENEKRPALVCRVTIDAD G S I GD di E F F AAW - IRS KA KL A YD NVSDWL E GKG E WQ PE N ------ 331
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 320 pehsv EE VHQAVLN LH SI A k QL R R Q RFVDG AL RL - D QLKLA F T LD h E T G LPQGC H IYEY R DS N KL VEE F M LL AN MAV A HK 398
Cdd:COG4776 332 ----- EE IAEQIRL LH QF A - LA R S Q WRQQH AL VF k D RPDYR F E LD - E K G NVLDI H AEPR R IA N RI VEE A M IA AN ICA A RV 404
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 399 -------- IF RT --- F - PE ----- QA LL RR H PPPQTK - M L SD L VE FC d QMGLPM D VSSAGA L NKS L TK -- TF GDDK ysla 458
Cdd:COG4776 405 lrehlgfg IF NV hsg F d PE kleqa VE LL AE H GIEFDP e Q L LT L EG FC - ALRREL D AQPTSY L DSR L RR fq TF AEIS ---- 479
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 459 rkevltnmysrpmqmalyfcsgmlqd Q E QFR H YA L NVPL Y THF TSPIR RFA D VIV HRL LA A AL gy SE QP DVE PD -- TLQK 536
Cdd:COG4776 480 -------------------------- T E PGP H FG L GLDA Y ATW TSPIR KYG D MVN HRL IK A VI -- LG QP AEK PD ee LTER 531
410
....*....|.
gi 1907067957 537 Q A DHCNDR RMA 547
Cdd:COG4776 532 L A ERRRLN RMA 542
PRK05054
PRK05054 exoribonuclease II; Provisional
162-551
1.71e-35
exoribonuclease II; Provisional
Pssm-ID: 179920 [Multi-domain]
Cd Length: 644
Bit Score: 142.32
E-value: 1.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 162 P W TIP p DE VGK R R DL RKDCIF TID PSTAR D L DDAL ACRR L T DG TFEVG V H IAD VSYFVP EGS S LDK V A AE RA TSV YL VQK 241
Cdd:PRK05054 180 A W EML - DE GLE R E DL TALDFV TID SASTE D M DDAL YVEK L P DG GLQLT V A IAD PTAYIA EGS K LDK A A RQ RA FTN YL PGF 258
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 242 VV PMLPR L L CEE LCSL N P MTDKLTFSVIWKLTPE G K I LEE -- W F GRT i I R S CT KL S YD HAQSMI EN PTEKI PE E elppis 319
Cdd:PRK05054 259 NI PMLPR E L SDD LCSL R P NERRPALACRVTIDAD G T I EDD ir F F AAW - I E S KA KL A YD NVSDWL EN GGDWQ PE S ------ 331
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 320 pehsv E EVHQAVLN LH SIA k QL R RQ - R FVDGALRL D QLKLA F T L D h E T G LPQGCHIYEY R DS N KL VEE F M LL AN MAV A H - 397
Cdd:PRK05054 332 ----- E AIAEQIRL LH QFC - LA R SE w R KQHALVFK D RPDYR F E L G - E K G EVLDIVAEPR R IA N RI VEE S M IA AN ICA A R v 404
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 398 ------- K I FRT ------- FP EQA -- LL RR H PPPQT - KM L SD L VE FC d QMGLPM D VSSA G A L NKSLTK -- T F GDDKYSLA 458
Cdd:PRK05054 405 lrdklgf G I YNV hsgfdpa NA EQA va LL KE H GLHFD a EE L LT L EG FC - KLRREL D AQPT G Y L DSRIRR fq S F AEISTEPG 483
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 459 rkevltnmysr P mqmalyfcsgmlqdqeqfr H YA L NVPL Y THF TSPIR RFA D V I V HRLL A A ALGYSEQPDVEPDTLQKQ A 538
Cdd:PRK05054 484 ----------- P ------------------- H FG L GLEA Y ATW TSPIR KYG D M I N HRLL K A VIKGETAERPQDEITVQL A 533
410
....*....|...
gi 1907067957 539 DHCNDR RMA SKR V 551
Cdd:PRK05054 534 ERRRLN RMA ERD V 546
Dis3l2_C_term
pfam17877 DIS3-like exonuclease 2 C terminal; This is the C-terminal S1 domain found in Dis3L2 proteins. ...
568-657
2.85e-31
DIS3-like exonuclease 2 C terminal; This is the C-terminal S1 domain found in Dis3L2 proteins. Dis3L2 belongs to the RNase II/R 3-5 exonuclease superfamily, which includes the catalytic subunit of the RNA exosome in yeast and in humans.
Pssm-ID: 465547
Cd Length: 87
Bit Score: 116.98
E-value: 2.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067957 568 GPLE S EA M V M GVL NQA FDVL VLRF G VQ KR I Y CNA L A L RSYS F Q K V G K kpe LTL V W EPDDLEEEPTQQVITIF SLV D VVL Q 647
Cdd:pfam17877 1 GPLE T EA V V L GVL DSS FDVL IPEY G IE KR V Y LDQ L P L KKFE F D K T G V --- LTL Y W KKGVPSSAYVPEDERFS SLV V VVL K 77
90
....*....|
gi 1907067957 648 AEATA LK YS A 657
Cdd:pfam17877 78 SDSDP LK LE A 87
OB_Dis3
pfam17849 Dis3-like cold-shock domain 2 (CSD2); This domain has an OB fold and is found in the Dis3l2 ...
67-143
8.55e-31
Dis3-like cold-shock domain 2 (CSD2); This domain has an OB fold and is found in the Dis3l2 protein. This domain along with CSD1 binds to RNA.
Pssm-ID: 436091 [Multi-domain]
Cd Length: 77
Bit Score: 115.01
E-value: 8.55e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907067957 67 Y A LF S P S D H R V PRI YV P L K DC P QD F MTR P K D FANT LF ICR I I DW K E DCNFA LG QLA K S LG QA G E IE P ETE G IL T E Y G 143
Cdd:pfam17849 1 Y V LF V P R D K R I PRI RI P T K SA P EE F LEN P E D LEGK LF VVK I D DW P E NSRYP LG HIV K V LG EI G D IE T ETE A IL L E N G 77
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
