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Conserved domains on  [gi|1907067590|ref|XP_036018404|]
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nucleoside diphosphate kinase 7 isoform X2 [Mus musculus]

Protein Classification

NDPk7A and NDPk7B domain-containing protein( domain architecture ID 11885871)

protein containing domains DM10_dom, NDPk7A, and NDPk7B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 75-205 2.35e-85

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239878  Cd Length: 131  Bit Score: 254.29  E-value: 2.35e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 154
Cdd:cd04415     1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907067590 155 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:cd04415    81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 221-354 2.63e-79

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239875  Cd Length: 134  Bit Score: 238.69  E-value: 2.63e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 221 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNP 300
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067590 301 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:cd04412    81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
DM10_dom super family cl26962
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 22-74 6.91e-15

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


The actual alignment was detected with superfamily member smart00676:

Pssm-ID: 474875  Cd Length: 104  Bit Score: 69.65  E-value: 6.91e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590   22 DVKNR----RTFLKRTKY--------EDLRLEDLFIGNKVNVFSRQLVLIDYgDQYTARQLGSRK 74
Cdd:smart00676  41 DVRNSgilqGTFLRRQRVpkpppddpEYYHASDLNVGTTINVFGRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 75-205 2.35e-85

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 254.29  E-value: 2.35e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 154
Cdd:cd04415     1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907067590 155 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:cd04415    81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 221-354 2.63e-79

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 238.69  E-value: 2.63e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 221 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNP 300
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067590 301 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:cd04412    81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 75-208 2.88e-64

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 200.47  E-value: 2.88e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590   75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590  153 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 208
Cdd:smart00562  81 KTWRTLMGPTDPREA---APGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK pfam00334
Nucleoside diphosphate kinase;
75-208 1.29e-58

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 185.77  E-value: 1.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590 153 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 208
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 221-358 2.13e-47

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 156.94  E-value: 2.13e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  221 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNP 300
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGK-PFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067590  301 TKTFREFCGPADPeiaRHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILD 358
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 75-206 4.10e-46

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 154.07  E-value: 4.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMeILR-DDA 151
Cdd:COG0105     3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAM-VLEgENA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590 152 ICEWKRLLGPANsglSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 206
Cdd:COG0105    82 VAVVRKLMGATN---PAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 75-208 9.54e-45

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 150.26  E-value: 9.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:PRK00668    2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067590 153 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 208
Cdd:PRK00668   82 AKVRELMGatnPAEA------APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDK pfam00334
Nucleoside diphosphate kinase;
223-355 2.32e-32

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 117.97  E-value: 2.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 223-355 8.33e-22

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 89.74  E-value: 8.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:COG0105     5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKG-KPFFGELVEFMTSGPVVAMVLEGENAVA 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:COG0105    84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 223-355 3.47e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 82.80  E-value: 3.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYkGVVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:PRK14542    4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIARhlrPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:PRK14542   83 HWREVIGATDPKEAA---AGTIRALYAESKEANAVHGSDSDANAALEISFFFK 132
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 22-74 6.91e-15

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 69.65  E-value: 6.91e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590   22 DVKNR----RTFLKRTKY--------EDLRLEDLFIGNKVNVFSRQLVLIDYgDQYTARQLGSRK 74
Cdd:smart00676  41 DVRNSgilqGTFLRRQRVpkpppddpEYYHASDLNVGTTINVFGRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 75-205 2.35e-85

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 254.29  E-value: 2.35e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 154
Cdd:cd04415     1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907067590 155 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:cd04415    81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 221-354 2.63e-79

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 238.69  E-value: 2.63e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 221 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNP 300
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067590 301 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:cd04412    81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 75-205 3.06e-67

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 207.98  E-value: 3.06e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVS--KAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:cd00595     1 ERTLALIKPDAVAegLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 153 CEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:cd00595    81 GEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 75-208 2.88e-64

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 200.47  E-value: 2.88e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590   75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590  153 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 208
Cdd:smart00562  81 KTWRTLMGPTDPREA---APGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK pfam00334
Nucleoside diphosphate kinase;
75-208 1.29e-58

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 185.77  E-value: 1.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590 153 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 208
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 221-354 8.17e-58

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 183.71  E-value: 8.17e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 221 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNP 300
Cdd:cd00595     1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGR-PFFPDLVQFMSSGPVVAMILEKDNA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067590 301 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:cd00595    80 VGEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 75-206 2.81e-50

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 164.53  E-value: 2.81e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 154
Cdd:cd04418     1 ERTLAIIKPDAVHKAEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907067590 155 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 206
Cdd:cd04418    81 WKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 221-358 2.13e-47

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 156.94  E-value: 2.13e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  221 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNP 300
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGK-PFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067590  301 TKTFREFCGPADPeiaRHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILD 358
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 75-205 2.97e-46

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 153.78  E-value: 2.97e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:cd04413     1 ERTLVIIKPDGVQRglIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 153 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:cd04413    81 KTVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 75-206 4.10e-46

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 154.07  E-value: 4.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMeILR-DDA 151
Cdd:COG0105     3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAM-VLEgENA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590 152 ICEWKRLLGPANsglSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 206
Cdd:COG0105    82 VAVVRKLMGATN---PAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 75-208 9.54e-45

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 150.26  E-value: 9.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:PRK00668    2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067590 153 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 208
Cdd:PRK00668   82 AKVRELMGatnPAEA------APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 75-205 4.02e-42

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 143.50  E-value: 4.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVS-KAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAIC 153
Cdd:cd04416     1 EYTLALIKPDAVAeKKDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907067590 154 EWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:cd04416    81 EWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 75-206 1.89e-41

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 141.77  E-value: 1.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVS---KAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDA 151
Cdd:cd04414     1 QLTLALIKPDAVAhplALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590 152 ICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 206
Cdd:cd04414    81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 72-205 8.20e-37

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 131.10  E-value: 8.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  72 SRKEKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRD 149
Cdd:PLN02931   27 SEEERTLAMIKPDGLSGnyTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKE 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590 150 DAICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PLN02931  107 NAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFF 162
NDK pfam00334
Nucleoside diphosphate kinase;
223-355 2.32e-32

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 117.97  E-value: 2.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 75-205 5.66e-30

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 111.69  E-value: 5.66e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:PRK14542    2 SRTFIMIKPDGVKNkhVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 153 CEWKRLLGPANsglSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PRK14542   82 LHWREVIGATD---PKEAAAGTIRALYAESKEANAVHGSDSDANAALEISFFF 131
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 74-205 7.45e-29

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 109.04  E-value: 7.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  74 KEKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDA 151
Cdd:PTZ00093    2 SERTFIMVKPDGVQRglVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067590 152 ICEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PTZ00093   82 VKQGRKLLGATNPLES---APGTIRGDFCVDVGRNVIHGSDSVESAKREIALWF 132
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 74-205 1.05e-28

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 108.37  E-value: 1.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  74 KEKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDA 151
Cdd:PRK14540    2 KERTFVALKPDAVERKliGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590 152 ICEWKRLLGPANSglsrTDA-PGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PRK14540   82 ISTVRKMIGKTNP----AEAePGTIRGDFGLYTPANIIHASDSKESAEREIKLFF 132
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 76-205 2.68e-26

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 101.91  E-value: 2.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  76 KTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAIC 153
Cdd:PRK14545    5 RTFTMIKPDAVENGhiGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907067590 154 EWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PRK14545   85 DFRTLIGATNPADA---AEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 75-205 4.37e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 98.87  E-value: 4.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:PRK14541    2 ERTLTILKPDCVRKQliGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590 153 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PRK14541   82 ADFRTLIGatdPAEA------AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 222-354 4.04e-24

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 95.74  E-value: 4.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 222 CTCCIIKPHAISEGMLgKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNPT 301
Cdd:cd04416     2 YTLALIKPDAVAEKKD-EILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEE-DYFEDLVEFMTSGPSLILVLSKENAV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 302 KTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:cd04416    80 EEWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 223-355 8.33e-22

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 89.74  E-value: 8.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:COG0105     5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKG-KPFFGELVEFMTSGPVVAMVLEGENAVA 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:COG0105    84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 223-355 3.47e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 82.80  E-value: 3.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYkGVVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:PRK14542    4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIARhlrPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:PRK14542   83 HWREVIGATDPKEAA---AGTIRALYAESKEANAVHGSDSDANAALEISFFFK 132
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 226-355 9.39e-17

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 75.91  E-value: 9.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 226 IIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTKTFR 305
Cdd:PRK00668    7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKE-KPFFGELVEFMTSGPVVVMVLEGENAIAKVR 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907067590 306 EFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:PRK00668   86 ELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFS 132
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 75-205 2.29e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 76.39  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHS--------------------------- 125
Cdd:PRK14544    4 ERTLVILKPDAVKRGlvGEIISRFEKAGLKIVAMKMVKATPEQIERFYPSSEEwyrsvgnkllkayqelgidprarlgtd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 126 ------RPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPAnsgLSRTDAPGSIRALFGTDG----------VRNAAH 189
Cdd:PRK14544   84 dpvevgKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPT---SPHKAPPGTIRGDYSIDSpdlaaeegrvVYNLVH 160

                         170
                  ....*....|....*.
gi 1907067590 190 GPDTFASAAREMELFF 205
Cdd:PRK14544  161 ASDSPEEAEREIKFWF 176
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 223-355 4.52e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 74.09  E-value: 4.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:PRK14540    5 TFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKG-KEFYERLINFMTSGRIVAMVIEGENAIS 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 303 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:PRK14540   84 TVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFG 133
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 220-354 5.54e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 73.79  E-value: 5.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 220 TNCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSN 299
Cdd:PRK14545    3 GNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAE-RPFYGELVEFMSRGPIVAAILEKEN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590 300 PTKTFREFCGPADPEIARHlrpETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:PRK14545   82 AVEDFRTLIGATNPADAAE---GTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 223-354 4.30e-15

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 71.28  E-value: 4.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISE-GMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSeYNDMVTELCSGPCVAIEIQQSNPT 301
Cdd:cd04414     3 TLALIKPDAVAHpLALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFF-YDRLVSFMTSGPSWALILAHENAI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067590 302 KTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:cd04414    82 KTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFF 134
PLN02619 PLN02619
nucleoside-diphosphate kinase
 75-205 5.81e-15

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 73.34  E-value: 5.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 152
Cdd:PLN02619   89 ERTFIAIKPDGVQRGliSEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGEGVI 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907067590 153 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 205
Cdd:PLN02619  169 KYGRKLIGatdPQKS------EPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWF 218
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 22-74 6.91e-15

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 69.65  E-value: 6.91e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907067590   22 DVKNR----RTFLKRTKY--------EDLRLEDLFIGNKVNVFSRQLVLIDYgDQYTARQLGSRK 74
Cdd:smart00676  41 DVRNSgilqGTFLRRQRVpkpppddpEYYHASDLNVGTTINVFGRQFRIYDC-DEFTRNYLESKG 104
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 223-354 8.04e-15

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 70.75  E-value: 8.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNPTK 302
Cdd:PRK14541    4 TLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRER-PFYGELVEFMSSGPCVPMILEKENAVA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907067590 303 TFREFCGPADPEIARHlrpETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 354
Cdd:PRK14541   83 DFRTLIGATDPAEAAE---GTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 75-205 5.38e-09

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 54.90  E-value: 5.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590  75 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFH-----VDHHSRPFYNELIQFITSGPVIAMEIL 147
Cdd:PRK14543    6 QKTLCIIKPDGVRRGliGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYlyddiAVRHGEAVWKSLIKFISSSPVFVFVVE 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067590 148 RDDAICEWKRLLGPANSGLSrtdAPGSIRALFGTD----------GVRNAAHGPDTFASAAREMELFF 205
Cdd:PRK14543   86 GVESVEVVRKFCGSTEPKLA---IPGTIRGDFSYHsfnyanekgfSVYNVIHASANEDDALREIPIWF 150
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 223-355 7.24e-09

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 54.51  E-value: 7.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYeVYKGVV-----SEYNDMVTELCSGPCVAIEIQQ 297
Cdd:PRK14543    8 TLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHY-LYDDIAvrhgeAVWKSLIKFISSSPVFVFVVEG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067590 298 SNPTKTFREFCGPADPEIArhlRPETLRAIFG----------KTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:PRK14543   87 VESVEVVRKFCGSTEPKLA---IPGTIRGDFSyhsfnyanekGFSVYNVIHASANEDDALREIPIWFK 151
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 223-355 8.81e-09

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 54.43  E-value: 8.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 223 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFY----EVYKGVVSE----YNDM------------- 281
Cdd:PRK14544    6 TLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseEWYRSVGNKllkaYQELgidprarlgtddp 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 282 -----------VTELCSGPCVAIEIQQSNPTKTFREFCGPADPEIArhlRPETLRAIFG----------KTKVQNAVHCT 340
Cdd:PRK14544   86 vevgkkvkeslVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSidspdlaaeeGRVVYNLVHAS 162

                         170
                  ....*....|....*
gi 1907067590 341 DLPEDGLLEVQYFFK 355
Cdd:PRK14544  163 DSPEEAEREIKFWFR 177
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 227-355 7.50e-07

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 48.18  E-value: 7.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067590 227 IKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNPTKTFRE 306
Cdd:PTZ00093    9 VKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGK-PFFPGLVKYISSGPVVCMVWEGKNVVKQGRK 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907067590 307 FCGPADPEIARhlrPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 355
Cdd:PTZ00093   88 LLGATNPLESA---PGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFK 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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