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Conserved domains on  [gi|1907067558|ref|XP_036018357|]
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protein crumbs homolog 1 isoform X7 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 292-427 9.40e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.79  E-value: 9.40e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  292 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067558  370 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 427
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 521-638 1.07e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  521 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 596
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1907067558  597 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 638
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 758-883 7.25e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 75.15  E-value: 7.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  758 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 836
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907067558  837 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 883
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 64-99 4.13e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558   64 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 99
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 102-138 3.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558  102 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 138
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-61 3.82e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558   26 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 61
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
175-216 4.41e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 4.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907067558   175 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 216
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1075-1111 8.98e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558 1075 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1111
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 454-485 7.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.34e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907067558  454 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 485
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 919-953 1.29e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907067558  919 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 953
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 955-990 1.31e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558  955 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 990
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1027 1.34e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558  992 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 1027
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 669-698 1.89e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.89e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907067558  669 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 698
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-169 2.52e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.52e-03
                            10        20
                    ....*....|....*....|..
gi 1907067558   148 PCHNDATCEDTVDSYICHCRPG 169
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPG 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 292-427 9.40e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.79  E-value: 9.40e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  292 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067558  370 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 427
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 521-638 1.07e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  521 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 596
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1907067558  597 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 638
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 263-427 1.74e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  263 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 340
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  341 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 419
Cdd:cd00110     78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                   ....*...
gi 1907067558  420 CLQDIRFD 427
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 758-883 7.25e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 75.15  E-value: 7.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  758 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 836
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907067558  837 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 883
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 498-636 3.81e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 3.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  498 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 573
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067558  574 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 636
Cdd:cd00110     85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 730-880 5.39e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 5.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  730 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 807
Cdd:cd00110      2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  808 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 880
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
753-882 6.17e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.98  E-value: 6.17e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558   753 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 830
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067558   831 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 882
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
287-427 2.03e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.44  E-value: 2.03e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558   287 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907067558   364 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 427
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
516-638 2.09e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 59.66  E-value: 2.09e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558   516 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 588
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1907067558   589 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 638
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 64-99 4.13e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558   64 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 99
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
63-99 6.91e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 6.91e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558    63 EIDECRS-QPCLHGATCQDAPGGYSCDCAPGF-LGEHCE 99
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 102-138 3.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558  102 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 138
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-61 3.82e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558   26 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 61
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
175-216 4.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 4.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907067558   175 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 216
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1075-1111 8.98e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558 1075 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1111
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 175-202 2.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.98e-05
                           10        20
                   ....*....|....*....|....*....
gi 1907067558  175 DVDECLL-HPCLNGGTCENLPGNYACHCP 202
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 67-97 5.95e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.95e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558   67 CRSQPCLHGATCQDAPGGYSCDCAPGFLGEH 97
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 454-485 7.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.34e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907067558  454 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 485
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
102-138 7.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 7.38e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558   102 VNECES-QPCLHGGLCVDGRNSYHCDCtGSGFT-GMHCE 138
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
25-61 1.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558    25 EVDECVS-DPCKNEAVCLNEIGRYTCVCPQEFS-GVNCE 61
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 454-484 1.18e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.18e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558  454 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 484
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 919-953 1.29e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907067558  919 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 953
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 955-990 1.31e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558  955 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 990
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1075-1111 2.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.43e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558  1075 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 1111
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1027 1.34e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558  992 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 1027
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 105-134 1.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907067558  105 CESQPCLHGGLCVDGRNSYHCDCTgSGFTG 134
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 669-698 1.89e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.89e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907067558  669 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 698
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 667-701 1.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.90e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907067558  667 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 701
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1079-1109 2.49e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.49e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558 1079 CASDPCINGGLCRDLVNRFLCICDVAFAGER 1109
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-169 2.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.52e-03
                            10        20
                    ....*....|....*....|..
gi 1907067558   148 PCHNDATCEDTVDSYICHCRPG 169
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-173 3.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.54e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907067558  148 PCHNDATCEDTVDSYICHCRPG---IHCE 173
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGytgRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 179-202 3.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.58e-03
                           10        20
                   ....*....|....*....|....
gi 1907067558  179 CLLHPCLNGGTCENLPGNYACHCP 202
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF_CA smart00179
Calcium-binding EGF-like domain;
924-953 4.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.84e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907067558   924 SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 953
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 959-1033 5.88e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 38.47  E-value: 5.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  959 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 1030
Cdd:PHA03099    53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                   ...
gi 1907067558 1031 RLP 1033
Cdd:PHA03099   130 KLP 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
955-990 6.19e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.19e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558   955 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 990
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 921-949 6.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.86e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907067558  921 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 949
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 29-59 9.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558   29 CVSDPCKNEAVCLNEIGRYTCVCPQEFSGVN 59
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 292-427 9.40e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.79  E-value: 9.40e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  292 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907067558  370 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 427
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 521-638 1.07e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  521 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 596
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1907067558  597 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 638
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 263-427 1.74e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  263 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 340
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  341 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 419
Cdd:cd00110     78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                   ....*...
gi 1907067558  420 CLQDIRFD 427
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 758-883 7.25e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 75.15  E-value: 7.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  758 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 836
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907067558  837 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 883
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 498-636 3.81e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 3.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  498 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 573
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067558  574 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 636
Cdd:cd00110     85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 730-880 5.39e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 5.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  730 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 807
Cdd:cd00110      2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  808 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 880
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
753-882 6.17e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.98  E-value: 6.17e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558   753 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 830
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067558   831 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 882
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
287-427 2.03e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.44  E-value: 2.03e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558   287 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907067558   364 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 427
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
516-638 2.09e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 59.66  E-value: 2.09e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558   516 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 588
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1907067558   589 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 638
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
758-882 1.92e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  758 FRTHDTNVMILHAEK--EPEFLNISIQDARLFFQLRSGNSfyTLHLMGSQLVNDGTWHQVTFSMIdpvaqTSRWQMEVND 835
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067558  836 QTPFVISEVaTGSLNFLKDNTDIYVG---DQSVDNP-----KGLQGCLSTIEIGG 882
Cdd:pfam00054   74 EARPTGESP-LGATTDLDVDGPLYVGglpSLGVKKRrlaisPSFDGCIRDVIVNG 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 64-99 4.13e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558   64 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 99
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
63-99 6.91e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 6.91e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558    63 EIDECRS-QPCLHGATCQDAPGGYSCDCAPGF-LGEHCE 99
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 102-138 3.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558  102 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 138
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
292-427 3.65e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 3.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  292 FHTVQPNALLLIRG--NKDVSMKLELLNGCVHLSIEVWNQlKVLLSISHNTSDGEWHFVEVTIAET-LTLALVGGSckek 368
Cdd:pfam00054    1 FRTTEPSGLLLYNGtqTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRsGTLSVDGEA---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067558  369 cTTKSSVPVENHQSICALQDSFLGGLPmgtannSVSVLNiYNVPSTPSFVGCLQDIRFD 427
Cdd:pfam00054   76 -RPTGESPLGATTDLDVDGPLYVGGLP------SLGVKK-RRLAISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-61 3.82e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558   26 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 61
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
175-216 4.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 4.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907067558   175 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 216
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1075-1111 8.98e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558 1075 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1111
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 175-202 2.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.98e-05
                           10        20
                   ....*....|....*....|....*....
gi 1907067558  175 DVDECLL-HPCLNGGTCENLPGNYACHCP 202
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 67-97 5.95e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.95e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558   67 CRSQPCLHGATCQDAPGGYSCDCAPGFLGEH 97
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 454-485 7.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.34e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907067558  454 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 485
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
102-138 7.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 7.38e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558   102 VNECES-QPCLHGGLCVDGRNSYHCDCtGSGFT-GMHCE 138
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
25-61 1.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558    25 EVDECVS-DPCKNEAVCLNEIGRYTCVCPQEFS-GVNCE 61
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 454-484 1.18e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.18e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558  454 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 484
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 919-953 1.29e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907067558  919 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 953
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 955-990 1.31e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907067558  955 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 990
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1075-1111 2.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.43e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558  1075 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 1111
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 66-99 3.82e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 3.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907067558   66 ECR-SQPCLHGATCQDAPGGYSCDCAPGFLGE-HCE 99
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1027 1.34e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067558  992 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 1027
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 105-134 1.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907067558  105 CESQPCLHGGLCVDGRNSYHCDCTgSGFTG 134
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 669-698 1.89e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.89e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907067558  669 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 698
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 667-701 1.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.90e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907067558  667 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 701
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1079-1109 2.49e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.49e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558 1079 CASDPCINGGLCRDLVNRFLCICDVAFAGER 1109
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Laminin_G_1 pfam00054
Laminin G domain;
521-641 2.52e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  521 VRTRQPLGLLLALENSTY-QYVSVWLEHGSL----------ALQTPGSPkfmvnffLSDGNVHLI---------SLRIKP 580
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLevsydlgsgaAVVRSGDK-------LNDGKWHSVelerngrsgTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907067558  581 NEIELYQS-SQNLGFISVPTwtirrgdVIFIGGLPDREKTE---VYGGFFKGCVQDVRLNSQTLE 641
Cdd:pfam00054   74 EARPTGESpLGATTDLDVDG-------PLYVGGLPSLGVKKrrlAISPSFDGCIRDVIVNGKPLD 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-169 2.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.52e-03
                            10        20
                    ....*....|....*....|..
gi 1907067558   148 PCHNDATCEDTVDSYICHCRPG 169
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-173 3.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.54e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907067558  148 PCHNDATCEDTVDSYICHCRPG---IHCE 173
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGytgRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 179-202 3.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.58e-03
                           10        20
                   ....*....|....*....|....
gi 1907067558  179 CLLHPCLNGGTCENLPGNYACHCP 202
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF_CA smart00179
Calcium-binding EGF-like domain;
924-953 4.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.84e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907067558   924 SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 953
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 959-1033 5.88e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 38.47  E-value: 5.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067558  959 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 1030
Cdd:PHA03099    53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                   ...
gi 1907067558 1031 RLP 1033
Cdd:PHA03099   130 KLP 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
955-990 6.19e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.19e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907067558   955 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 990
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 921-949 6.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.86e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907067558  921 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 949
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 72-93 7.91e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.00  E-value: 7.91e-03
                           10        20
                   ....*....|....*....|..
gi 1907067558   72 CLHGATCQDAPGGYSCDCAPGF 93
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 29-59 9.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907067558   29 CVSDPCKNEAVCLNEIGRYTCVCPQEFSGVN 59
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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