NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907205960|ref|XP_036017971|]
View 

tafazzin isoform X13 [Mus musculus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 41-158 1.13e-13

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member pfam01553:

Pssm-ID: 473073 [Multi-domain]  Cd Length: 131  Bit Score: 64.22  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960  41 HLTVHNKEVLYElienrgpATPLITVSNHQSCMDDPHLWGILKLRHiwnlkLMRWTPAAADICFTKeLHSHFFSLGKCVP 120
Cdd:pfam01553   1 RIEVHGLENLPR-------GGPAIVVANHQSYLDVLLLSLALYKRG-----RPLVFVAKKELFDIP-LVGWLMRLLGCIF 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907205960 121 VCR----------------------------GKVNMSSEFLRFKWGIGRLIAEchLNPIILPLWHV 158
Cdd:pfam01553  68 IDRknrkdaagtleylvellregklvvifpeGTRSREGELLPFKKGAFRLAIE--AGVPIVPVAIS 131
 
Name Accession Description Interval E-value
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 41-158 1.13e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 64.22  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960  41 HLTVHNKEVLYElienrgpATPLITVSNHQSCMDDPHLWGILKLRHiwnlkLMRWTPAAADICFTKeLHSHFFSLGKCVP 120
Cdd:pfam01553   1 RIEVHGLENLPR-------GGPAIVVANHQSYLDVLLLSLALYKRG-----RPLVFVAKKELFDIP-LVGWLMRLLGCIF 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907205960 121 VCR----------------------------GKVNMSSEFLRFKWGIGRLIAEchLNPIILPLWHV 158
Cdd:pfam01553  68 IDRknrkdaagtleylvellregklvvifpeGTRSREGELLPFKKGAFRLAIE--AGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 63-158 3.76e-10

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 54.67  E-value: 3.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960   63 LITVSNHQSCMDDPHLWGILKLRHIwnlklmRWTPAAADICFTKELHSHFFSLGKCVPVCR------------------- 123
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLG------RVRFVAKKELFYVPLLGWLLRLLGAIFIDRsngrkaraalreavellke 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907205960  124 ---------GKVNMSSEFLRFKWGIGRLIAECHlnPIILPLWHV 158
Cdd:smart00563  75 gewllifpeGTRSRPGKLLPFKKGAARLALEAG--VPIVPVAIR 116
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 34-157 1.17e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 51.89  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960  34 FWTKYMNHLTVHNKEvlyelieNRGPATPLITVSNHQSCMdDPHLWGILKLRHIwnlklmRWTpAAADIcFTKELHSHFF 113
Cdd:cd07989     4 LLRLLGVRVRVEGLE-------NLPPKGPVIIVANHQSYL-DPLVLGAALPRPI------RFV-AKKEL-FKIPFLGWLL 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907205960 114 SLGKCVPVCR----------------------------GKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWH 157
Cdd:cd07989    68 RLLGAIPIDRgngrsarealreaiealkegesvvifpeGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAI 137
 
Name Accession Description Interval E-value
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 41-158 1.13e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 64.22  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960  41 HLTVHNKEVLYElienrgpATPLITVSNHQSCMDDPHLWGILKLRHiwnlkLMRWTPAAADICFTKeLHSHFFSLGKCVP 120
Cdd:pfam01553   1 RIEVHGLENLPR-------GGPAIVVANHQSYLDVLLLSLALYKRG-----RPLVFVAKKELFDIP-LVGWLMRLLGCIF 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907205960 121 VCR----------------------------GKVNMSSEFLRFKWGIGRLIAEchLNPIILPLWHV 158
Cdd:pfam01553  68 IDRknrkdaagtleylvellregklvvifpeGTRSREGELLPFKKGAFRLAIE--AGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 63-158 3.76e-10

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 54.67  E-value: 3.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960   63 LITVSNHQSCMDDPHLWGILKLRHIwnlklmRWTPAAADICFTKELHSHFFSLGKCVPVCR------------------- 123
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLG------RVRFVAKKELFYVPLLGWLLRLLGAIFIDRsngrkaraalreavellke 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907205960  124 ---------GKVNMSSEFLRFKWGIGRLIAECHlnPIILPLWHV 158
Cdd:smart00563  75 gewllifpeGTRSRPGKLLPFKKGAARLALEAG--VPIVPVAIR 116
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 34-157 1.17e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 51.89  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907205960  34 FWTKYMNHLTVHNKEvlyelieNRGPATPLITVSNHQSCMdDPHLWGILKLRHIwnlklmRWTpAAADIcFTKELHSHFF 113
Cdd:cd07989     4 LLRLLGVRVRVEGLE-------NLPPKGPVIIVANHQSYL-DPLVLGAALPRPI------RFV-AKKEL-FKIPFLGWLL 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907205960 114 SLGKCVPVCR----------------------------GKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWH 157
Cdd:cd07989    68 RLLGAIPIDRgngrsarealreaiealkegesvvifpeGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAI 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH