E3 ubiquitin-protein ligase XIAP isoform X4 [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
162-232 | 2.12e-36 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. : Pssm-ID: 197595 Cd Length: 71 Bit Score: 128.20 E-value: 2.12e-36
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| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
264-330 | 1.31e-29 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. : Pssm-ID: 197595 Cd Length: 71 Bit Score: 109.71 E-value: 1.31e-29
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
28-95 | 1.75e-27 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. : Pssm-ID: 237989 Cd Length: 69 Bit Score: 103.88 E-value: 1.75e-27
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| UBA_BIRC4_8 | cd14395 | UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing ... |
369-418 | 6.12e-26 | ||
UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins; XIAP, also called baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein (ILP), inhibitor of apoptosis protein 3 (IAP-3), or X-linked inhibitor of apoptosis protein (X-linked IAP), is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases, including caspase-3, -7, and -9. It promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. The ubiquitin-protein ligase (E3) activity of XIAP also exhibits in the ubiquitination of second mitochondria-derived activator of caspases (Smac). The mitochondrial proteins, Smac/DIABLO and Omi/HtrA2, can inhibit the antiapoptotic activity of XIAP. XIAP has also been implicated in several intracellular signaling cascades involved in the cellular response to stress, such as the c-Jun N-terminal kinase (JNK) pathway, the nuclear factor-kappaB (NF-kappaB) pathway, and the transforming growth factor-beta (TGF-beta) pathway. Moreover, XIAP can regulate copper homeostasis through interacting with MURR1. BIRC8, also called inhibitor of apoptosis-like protein 2 (IAP-like protein 2 or ILP-2), or testis-specific inhibitor of apoptosis, is a tissue-specific homolog of E3 ubiquitin-protein ligase XIAP. It has been implicated in the control of apoptosis in the testis by direct inhibition of caspase 9. Both XIAP and BIRC8 contain three N-terminal baculoviral IAP repeat (BIR) domains, a ubiquitin-association (UBA) domain and a RING domain at the carboxyl terminus. : Pssm-ID: 270578 Cd Length: 50 Bit Score: 99.14 E-value: 6.12e-26
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| Name | Accession | Description | Interval | E-value | ||
| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
162-232 | 2.12e-36 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. Pssm-ID: 197595 Cd Length: 71 Bit Score: 128.20 E-value: 2.12e-36
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
164-232 | 5.77e-35 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. Pssm-ID: 237989 Cd Length: 69 Bit Score: 124.30 E-value: 5.77e-35
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| BIR | pfam00653 | Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
166-230 | 1.66e-30 | ||
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin. Pssm-ID: 459891 Cd Length: 68 Bit Score: 112.37 E-value: 1.66e-30
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| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
264-330 | 1.31e-29 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. Pssm-ID: 197595 Cd Length: 71 Bit Score: 109.71 E-value: 1.31e-29
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
265-330 | 5.25e-28 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. Pssm-ID: 237989 Cd Length: 69 Bit Score: 105.43 E-value: 5.25e-28
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
28-95 | 1.75e-27 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. Pssm-ID: 237989 Cd Length: 69 Bit Score: 103.88 E-value: 1.75e-27
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| UBA_BIRC4_8 | cd14395 | UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing ... |
369-418 | 6.12e-26 | ||
UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins; XIAP, also called baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein (ILP), inhibitor of apoptosis protein 3 (IAP-3), or X-linked inhibitor of apoptosis protein (X-linked IAP), is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases, including caspase-3, -7, and -9. It promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. The ubiquitin-protein ligase (E3) activity of XIAP also exhibits in the ubiquitination of second mitochondria-derived activator of caspases (Smac). The mitochondrial proteins, Smac/DIABLO and Omi/HtrA2, can inhibit the antiapoptotic activity of XIAP. XIAP has also been implicated in several intracellular signaling cascades involved in the cellular response to stress, such as the c-Jun N-terminal kinase (JNK) pathway, the nuclear factor-kappaB (NF-kappaB) pathway, and the transforming growth factor-beta (TGF-beta) pathway. Moreover, XIAP can regulate copper homeostasis through interacting with MURR1. BIRC8, also called inhibitor of apoptosis-like protein 2 (IAP-like protein 2 or ILP-2), or testis-specific inhibitor of apoptosis, is a tissue-specific homolog of E3 ubiquitin-protein ligase XIAP. It has been implicated in the control of apoptosis in the testis by direct inhibition of caspase 9. Both XIAP and BIRC8 contain three N-terminal baculoviral IAP repeat (BIR) domains, a ubiquitin-association (UBA) domain and a RING domain at the carboxyl terminus. Pssm-ID: 270578 Cd Length: 50 Bit Score: 99.14 E-value: 6.12e-26
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| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
26-95 | 6.61e-26 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. Pssm-ID: 197595 Cd Length: 71 Bit Score: 99.70 E-value: 6.61e-26
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| BIR | pfam00653 | Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
267-329 | 1.34e-24 | ||
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin. Pssm-ID: 459891 Cd Length: 68 Bit Score: 96.19 E-value: 1.34e-24
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| BIR | pfam00653 | Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
29-93 | 1.22e-23 | ||
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin. Pssm-ID: 459891 Cd Length: 68 Bit Score: 93.49 E-value: 1.22e-23
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| Name | Accession | Description | Interval | E-value | ||
| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
162-232 | 2.12e-36 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. Pssm-ID: 197595 Cd Length: 71 Bit Score: 128.20 E-value: 2.12e-36
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
164-232 | 5.77e-35 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. Pssm-ID: 237989 Cd Length: 69 Bit Score: 124.30 E-value: 5.77e-35
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| BIR | pfam00653 | Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
166-230 | 1.66e-30 | ||
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin. Pssm-ID: 459891 Cd Length: 68 Bit Score: 112.37 E-value: 1.66e-30
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| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
264-330 | 1.31e-29 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. Pssm-ID: 197595 Cd Length: 71 Bit Score: 109.71 E-value: 1.31e-29
|
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
265-330 | 5.25e-28 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. Pssm-ID: 237989 Cd Length: 69 Bit Score: 105.43 E-value: 5.25e-28
|
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| BIR | cd00022 | Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
28-95 | 1.75e-27 | ||
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger. Pssm-ID: 237989 Cd Length: 69 Bit Score: 103.88 E-value: 1.75e-27
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| UBA_BIRC4_8 | cd14395 | UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing ... |
369-418 | 6.12e-26 | ||
UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins; XIAP, also called baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein (ILP), inhibitor of apoptosis protein 3 (IAP-3), or X-linked inhibitor of apoptosis protein (X-linked IAP), is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases, including caspase-3, -7, and -9. It promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. The ubiquitin-protein ligase (E3) activity of XIAP also exhibits in the ubiquitination of second mitochondria-derived activator of caspases (Smac). The mitochondrial proteins, Smac/DIABLO and Omi/HtrA2, can inhibit the antiapoptotic activity of XIAP. XIAP has also been implicated in several intracellular signaling cascades involved in the cellular response to stress, such as the c-Jun N-terminal kinase (JNK) pathway, the nuclear factor-kappaB (NF-kappaB) pathway, and the transforming growth factor-beta (TGF-beta) pathway. Moreover, XIAP can regulate copper homeostasis through interacting with MURR1. BIRC8, also called inhibitor of apoptosis-like protein 2 (IAP-like protein 2 or ILP-2), or testis-specific inhibitor of apoptosis, is a tissue-specific homolog of E3 ubiquitin-protein ligase XIAP. It has been implicated in the control of apoptosis in the testis by direct inhibition of caspase 9. Both XIAP and BIRC8 contain three N-terminal baculoviral IAP repeat (BIR) domains, a ubiquitin-association (UBA) domain and a RING domain at the carboxyl terminus. Pssm-ID: 270578 Cd Length: 50 Bit Score: 99.14 E-value: 6.12e-26
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| BIR | smart00238 | Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
26-95 | 6.61e-26 | ||
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes. Pssm-ID: 197595 Cd Length: 71 Bit Score: 99.70 E-value: 6.61e-26
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| BIR | pfam00653 | Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
267-329 | 1.34e-24 | ||
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin. Pssm-ID: 459891 Cd Length: 68 Bit Score: 96.19 E-value: 1.34e-24
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| BIR | pfam00653 | Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
29-93 | 1.22e-23 | ||
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin. Pssm-ID: 459891 Cd Length: 68 Bit Score: 93.49 E-value: 1.22e-23
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| UBA_IAPs | cd14321 | UBA domain found in inhibitor of apoptosis proteins (IAPs); IAPs are frequently overexpressed ... |
373-416 | 6.44e-10 | ||
UBA domain found in inhibitor of apoptosis proteins (IAPs); IAPs are frequently overexpressed in cancer and associated with tumor cell survival, chemoresistance, disease progression and poor prognosis. They function primarily as negative regulators of cell death. They regulate caspases and apoptosis through the inhibition of specific members of the caspase family of cysteine proteases. In addition, IAPs has been implicated in a multitude of other cellular processes, including inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis. IAPs in this family includes cellular inhibitor of apoptosis protein c-IAP1 and c-IAP2, XIAP, and BIRC8, all of which contain three N-terminal baculoviral IAP repeat (BIR) domains that enable interactions with proteins, a ubiquitin-association (UBA) domain that is responsible for the binding of binds polyubiquitin (polyUb), and a RING domain at the carboxyl terminus that is required for ubiquitin ligase activity. c-IAPs contains an additional caspase activation and recruitment domain (CARD) between UBA and RING domains. CARD domain may serve as a protein interaction surface. Pssm-ID: 270506 Cd Length: 44 Bit Score: 54.35 E-value: 6.44e-10
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| UBA_BIRC2_3 | cd14394 | UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar ... |
372-419 | 2.98e-09 | ||
UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins; The subfamily includes cellular inhibitor of apoptosis protein 1 (c-IAP1) and c-IAP2. c-IAPs function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB)signaling, and oncogenesis. Unlike other apoptosis proteins (IAPs), such as XIAP, c-IAPs exhibit minimal binding to caspases and may not play an important role in the inhibition of these proteases. c-IAP1, also called baculoviral IAP repeat-containing protein BIRC2, IAP-2, RING finger protein 48, or TNFR2-TRAF-signaling complex protein 2, is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-kappaB signaling pathways in the cytoplasm. It can also regulate E2F1 transcription factor-mediated control of cyclin transcription in the nucleus. c-IAP2, also called BIRC3, IAP-1, apoptosis inhibitor 2 (API2), or IAP homolog C, also influences ubiquitin-dependent pathways that modulate innate immune signalling by activation of NF-kappaB. c-IAPs contain three N-terminal baculoviral IAP repeat (BIR) domains that enable interactions with proteins, a ubiquitin-association (UBA) domain that is responsible for the binding of binds polyubiquitin (polyUb), a caspase activation and recruitment domain (CARD) that serves as a protein interaction surface, and a RING domain at the carboxyl terminus that is required for ubiquitin ligase activity. Pssm-ID: 270577 Cd Length: 50 Bit Score: 52.61 E-value: 2.98e-09
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| UBA_XtBIRC7_like | cd14396 | UBA domain found in Xenopus tropicalis baculoviral IAP repeat-containing protein BIRC7, ... |
373-416 | 7.91e-03 | ||
UBA domain found in Xenopus tropicalis baculoviral IAP repeat-containing protein BIRC7, BIRC71A and similar proteins; X. tropicalis BIRC7, also called E3 ubiquitin-protein ligase EIAP, embryonic/Egg IAP (xEIAP/XLX), inhibitor of apoptosis (IAP)-like protein, XIAP homolog XLX, is a weak apoptosis inhibitor that exhibits caspase inhibition and autoubiquitylation. It is uniquely modified by MAPK- and Cdc2/Cyclin B-dependent phosphorylation during oocyte maturation. Its caspase-dependent cleavage is altered when it is phosphorylated. X. tropicalis BIRC7 contains two N-terminal baculoviral IAP repeats (BIRs) and a C-terminal RING domain. Based on sequence homology, it also harbors a ubiquitin-associated (UBA) domain which is not detected in human BIRC7. Pssm-ID: 270579 Cd Length: 44 Bit Score: 34.29 E-value: 7.91e-03
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