NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907131851|ref|XP_036017347|]
View 

latent-transforming growth factor beta-binding protein 3 isoform X5 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 411-452 5.55e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 5.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907131851  411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 926-968 4.43e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907131851  926 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 968
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-387 1.81e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.81e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907131851   352 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
741-781 2.96e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907131851   741 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 657-691 8.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907131851  657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 691
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
782-822 1.33e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.33e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907131851   782 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 822
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1096-1132 2.20e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.65  E-value: 2.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907131851 1096 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1132
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
863-896 3.41e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.41e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907131851   863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
823-862 6.92e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907131851   823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1033-1061 4.75e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.75e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907131851  1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
700-733 1.43e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1907131851   700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-656 1.94e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.94e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907131851   613 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 656
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1204-1242 4.10e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.10e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907131851  1204 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1242
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 288-318 4.26e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.26e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 411-452 5.55e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 5.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907131851  411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 926-968 4.43e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907131851  926 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 968
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-387 1.81e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.81e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907131851   352 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
741-781 2.96e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907131851   741 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 657-691 8.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907131851  657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 691
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
782-822 1.33e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.33e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907131851   782 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 822
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-689 1.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.57e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907131851   657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 689
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1096-1132 2.20e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.65  E-value: 2.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907131851 1096 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1132
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-384 2.36e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907131851  352 DINECAMPGMCR-HGDCLNNPGSYRCVCPPGHSL 384
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
863-896 3.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.41e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907131851   863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 741-772 3.46e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.46e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907131851  741 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 772
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 863-898 4.83e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907131851  863 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 898
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 782-816 6.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907131851  782 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 816
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
823-862 6.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907131851   823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 823-862 1.70e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907131851  823 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 862
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1033-1061 4.75e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.75e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907131851  1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
823-852 6.57e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 6.57e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  823 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 852
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
352-381 1.01e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  352 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 381
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
700-733 1.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1907131851   700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1033-1061 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907131851 1033 DVDECLDESNCRN-GVCENTRGGYRCACTP 1061
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-656 1.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.94e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907131851   613 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 656
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
782-811 2.50e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.50e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  782 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 811
Cdd:pfam07645    1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 700-732 3.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907131851  700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 732
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-647 3.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907131851  613 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 647
Cdd:cd00054      1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1204-1242 4.10e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.10e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907131851  1204 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1242
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 288-318 4.26e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.26e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 411-452 5.55e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 5.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907131851  411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 926-968 4.43e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907131851  926 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 968
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-387 1.81e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.81e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907131851   352 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
741-781 2.96e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907131851   741 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 657-691 8.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907131851  657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 691
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
782-822 1.33e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.33e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907131851   782 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 822
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-689 1.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.57e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907131851   657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 689
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1096-1132 2.20e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.65  E-value: 2.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907131851 1096 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1132
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-384 2.36e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907131851  352 DINECAMPGMCR-HGDCLNNPGSYRCVCPPGHSL 384
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
863-896 3.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.41e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907131851   863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 741-772 3.46e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.46e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907131851  741 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 772
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 863-898 4.83e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907131851  863 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 898
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 782-816 6.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907131851  782 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 816
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
823-862 6.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907131851   823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 823-862 1.70e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907131851  823 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 862
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1033-1061 4.75e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.75e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907131851  1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
823-852 6.57e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 6.57e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  823 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 852
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
352-381 1.01e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  352 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 381
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 858-901 1.11e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 1.11e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907131851  858 GRKCQDIDECSqdpglCLPHG---ACENLQGSYVCVCDEGFTLTQDQ 901
Cdd:cd01475    181 GKICVVPDLCA-----TLSHVcqqVCISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
700-733 1.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1907131851   700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1033-1061 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907131851 1033 DVDECLDESNCRN-GVCENTRGGYRCACTP 1061
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-656 1.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.94e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907131851   613 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 656
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
782-811 2.50e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.50e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  782 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 811
Cdd:pfam07645    1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 780-817 2.94e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907131851  780 CIDVDECEAG-KVCQDgICTNTPGSFQCQCLSGYHLSRD 817
Cdd:cd01475    184 CVVPDLCATLsHVCQQ-VCISTPGSYLCACTEGYALLED 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 700-732 3.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907131851  700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 732
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-647 3.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907131851  613 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 647
Cdd:cd00054      1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
355-387 3.72e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 3.72e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907131851   355 ECAMPGMCRHGDCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1204-1242 4.10e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.10e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907131851  1204 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1242
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 288-318 4.26e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.26e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907131851  288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 660-693 8.69e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 8.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907131851  660 ECTKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 693
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH