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Conserved domains on  [gi|1907138448|ref|XP_036017010|]
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tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE super family cl43651
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 209-271 4.79e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


The actual alignment was detected with superfamily member COG2226:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.90  E-value: 4.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138448 209 VCDDGLAYPFPDG-----ILDvvllvfvlSSIH--PDRMQAVAHrLSRLLKPGGMLLFRDHGRYDNAQLR 271
Cdd:COG2226    74 VVGDAEDLPFPDGsfdlvISS--------FVLHhlPDPERALAE-IARVLKPGGRLVVVDFSPPDLAELE 134
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 242-308 5.93e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam13489:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 162  Bit Score: 37.02  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907138448 242 AVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENfyvrgdGTRAYFFTKGEIRRMFCEAGL 308
Cdd:pfam13489  98 ALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPR------NGHISLFSARSLKRLLEEAGF 158
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 209-271 4.79e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.90  E-value: 4.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138448 209 VCDDGLAYPFPDG-----ILDvvllvfvlSSIH--PDRMQAVAHrLSRLLKPGGMLLFRDHGRYDNAQLR 271
Cdd:COG2226    74 VVGDAEDLPFPDGsfdlvISS--------FVLHhlPDPERALAE-IARVLKPGGRLVVVDFSPPDLAELE 134
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 242-308 5.93e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.02  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907138448 242 AVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENfyvrgdGTRAYFFTKGEIRRMFCEAGL 308
Cdd:pfam13489  98 ALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPR------NGHISLFSARSLKRLLEEAGF 158
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
235-315 9.46e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.51  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138448 235 IHPDRMQAVAHRLSRLLKPGGMLLFrdhgrydnaqlrfkkgrclSENfyvRGDGTRAYFFTKGEIRRMFCEAGLHEKQNL 314
Cdd:COG4976   118 TYLGDLAAVFAGVARALKPGGLFIF-------------------SVE---DADGSGRYAHSLDYVRDLLAAAGFEVPGLL 175


                  .
gi 1907138448 315 V 315
Cdd:COG4976   176 V 176
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 209-271 4.79e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.90  E-value: 4.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138448 209 VCDDGLAYPFPDG-----ILDvvllvfvlSSIH--PDRMQAVAHrLSRLLKPGGMLLFRDHGRYDNAQLR 271
Cdd:COG2226    74 VVGDAEDLPFPDGsfdlvISS--------FVLHhlPDPERALAE-IARVLKPGGRLVVVDFSPPDLAELE 134
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 242-308 5.93e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.02  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907138448 242 AVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENfyvrgdGTRAYFFTKGEIRRMFCEAGL 308
Cdd:pfam13489  98 ALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPR------NGHISLFSARSLKRLLEEAGF 158
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
235-315 9.46e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.51  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138448 235 IHPDRMQAVAHRLSRLLKPGGMLLFrdhgrydnaqlrfkkgrclSENfyvRGDGTRAYFFTKGEIRRMFCEAGLHEKQNL 314
Cdd:COG4976   118 TYLGDLAAVFAGVARALKPGGLFIF-------------------SVE---DADGSGRYAHSLDYVRDLLAAAGFEVPGLL 175


                  .
gi 1907138448 315 V 315
Cdd:COG4976   176 V 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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