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Conserved domains on  [gi|1907138349|ref|XP_036016902|]
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plakophilin-4 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-613 6.98e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.46  E-value: 6.98e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907138349  574 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 613
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 880-915 7.38e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 7.38e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907138349   880 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 915
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 618-659 7.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 7.98e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907138349   618 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 659
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-382 4.90e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 4.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349   72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTIHPNNYLIRTEPEQGtLYSPEQTSlhESEGS 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDTEEPERATAKKSKTQE-ISRPNSPS--EGEGE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  140 LGNSRsstqmnSYSDSGYQEAGSFHNSqtvNKADSRQHPftGSTSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRA 218
Cdd:pfam03154  120 SSDGR------SVNDEGSSDPKDIDQD---NRSTSPSIP--SPQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPP 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  219 QSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQT 295
Cdd:pfam03154  189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQ 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  296 SNPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDI 370
Cdd:pfam03154  269 PSLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPP 340

                          330
                   ....*....|..
gi 1907138349  371 YERMVPPRPDSL 382
Cdd:pfam03154  341 REQPLPPAPLSM 352
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 863-984 1.88e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.40  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  863 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 936
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907138349  937 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 984
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 964-1008 5.65e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.48  E-value: 5.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907138349   964 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 1008
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-613 6.98e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.46  E-value: 6.98e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907138349  574 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 613
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-614 1.42e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 51.28  E-value: 1.42e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138349   574 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 614
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 880-915 7.38e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 7.38e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907138349   880 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 915
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 618-659 7.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 7.98e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907138349   618 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 659
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 618-659 2.70e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.14  E-value: 2.70e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138349  618 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 659
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-382 4.90e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 4.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349   72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTIHPNNYLIRTEPEQGtLYSPEQTSlhESEGS 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDTEEPERATAKKSKTQE-ISRPNSPS--EGEGE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  140 LGNSRsstqmnSYSDSGYQEAGSFHNSqtvNKADSRQHPftGSTSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRA 218
Cdd:pfam03154  120 SSDGR------SVNDEGSSDPKDIDQD---NRSTSPSIP--SPQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPP 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  219 QSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQT 295
Cdd:pfam03154  189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQ 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  296 SNPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDI 370
Cdd:pfam03154  269 PSLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPP 340

                          330
                   ....*....|..
gi 1907138349  371 YERMVPPRPDSL 382
Cdd:pfam03154  341 REQPLPPAPLSM 352
HEAT COG1413
HEAT repeat [General function prediction only];
541-663 2.03e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  541 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 619
Cdd:COG1413     13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907138349  620 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 663
Cdd:COG1413     75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 880-915 3.19e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138349  880 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 915
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 220-377 1.26e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  220 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSAYSSSTLPA----------QRAASPY----------SQRPA 279
Cdd:PLN03209   385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  280 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 351
Cdd:PLN03209   457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1907138349  352 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 377
Cdd:PLN03209   537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 863-984 1.88e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.40  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  863 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 936
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907138349  937 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 984
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 964-1008 5.65e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.48  E-value: 5.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907138349   964 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 1008
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 545-659 9.35e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 9.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  545 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 623
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907138349  624 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 659
Cdd:PLN03200   136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-613 6.98e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.46  E-value: 6.98e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907138349  574 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 613
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-614 1.42e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 51.28  E-value: 1.42e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138349   574 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 614
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 880-915 7.38e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 7.38e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907138349   880 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 915
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 618-659 7.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 7.98e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907138349   618 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 659
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 618-659 2.70e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.14  E-value: 2.70e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138349  618 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 659
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-382 4.90e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 4.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349   72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTIHPNNYLIRTEPEQGtLYSPEQTSlhESEGS 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDTEEPERATAKKSKTQE-ISRPNSPS--EGEGE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  140 LGNSRsstqmnSYSDSGYQEAGSFHNSqtvNKADSRQHPftGSTSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRA 218
Cdd:pfam03154  120 SSDGR------SVNDEGSSDPKDIDQD---NRSTSPSIP--SPQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPP 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  219 QSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQT 295
Cdd:pfam03154  189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQ 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  296 SNPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDI 370
Cdd:pfam03154  269 PSLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPP 340

                          330
                   ....*....|..
gi 1907138349  371 YERMVPPRPDSL 382
Cdd:pfam03154  341 REQPLPPAPLSM 352
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 71-357 7.94e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.49  E-value: 7.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349   71 LGAESPSIASTSSTEKSFPWRSTDVPNPgVSKPRVSDTIHPNNYLIRTEpeqgtlYSPEQTSLHE---SEGSLGNSRSST 147
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAP-VTLTKGTSAAHLNSTEVTAE------HTPHGTDLSEpatREGAADGAASRA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  148 QMNSYSDSGYQEAGSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTSt 227
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASS- 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  228 gvSPSRGSLRTSlgsgfgsPSVTDSRPLNPSAYSSSTlPAqrAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQY-Q 306
Cdd:pfam17823  194 --APTTAASSAP-------ATLTPARGISTAATATGH-PA--AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAaG 261

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907138349  307 TTTRVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTV 357
Cdd:pfam17823  262 TVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVST 312
HEAT COG1413
HEAT repeat [General function prediction only];
541-663 2.03e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  541 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 619
Cdd:COG1413     13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907138349  620 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 663
Cdd:COG1413     75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 880-915 3.19e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138349  880 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 915
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 220-377 1.26e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  220 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSAYSSSTLPA----------QRAASPY----------SQRPA 279
Cdd:PLN03209   385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  280 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 351
Cdd:PLN03209   457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1907138349  352 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 377
Cdd:PLN03209   537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 863-984 1.88e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.40  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  863 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 936
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907138349  937 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 984
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 964-1008 5.65e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.48  E-value: 5.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907138349   964 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 1008
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 545-659 9.35e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 9.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138349  545 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 623
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907138349  624 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 659
Cdd:PLN03200   136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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