SETD4 family SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein similar to the SET domain region of Homo sapiens SET domain-containing protein 4 (SETD4), a histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
49-286
1.37e-105
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
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Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 309.62 E-value: 1.37e-105
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
49-286
1.37e-105
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 309.62 E-value: 1.37e-105
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
49-286
1.37e-105
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 309.62 E-value: 1.37e-105
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
52-286
3.06e-58
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.
Pssm-ID: 380925 [Multi-domain] Cd Length: 236 Bit Score: 188.43 E-value: 3.06e-58
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
58-286
2.66e-39
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.
Pssm-ID: 380956 Cd Length: 237 Bit Score: 139.37 E-value: 2.66e-39
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
34-286
5.80e-35
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.
Pssm-ID: 380953 Cd Length: 251 Bit Score: 128.14 E-value: 5.80e-35
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
55-286
1.41e-29
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).
Pssm-ID: 380957 Cd Length: 252 Bit Score: 113.97 E-value: 1.41e-29
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
57-286
6.72e-11
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 61.94 E-value: 6.72e-11
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
225-285
7.95e-04
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.
Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 40.36 E-value: 7.95e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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