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Conserved domains on  [gi|1907117575|ref|XP_036015785|]
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polyamine-transporting ATPase 13A3 isoform X1 [Mus musculus]

Protein Classification

cation-translocating P-type ATPase( domain architecture ID 11492996)

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle; similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
14-1142 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


:

Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1357.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   14 EDEMEIHGYNLCRWKLAMVFVGVICTGGFLLLLLYWLPEWRVKATCVRAAVKDCEVVLLRTTDEFRvwfcakIHFLPVEN 93
Cdd:TIGR01657    1 DKTIGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDPTPNS------GSDYIVEL 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   94 QPnlnaKCLVNEVSNGHAVHLTEENRCEmnkysqsQSQQMRYFTHHSIRYFWNDAIHNFDFLKgldEGVSCASLYEKHsa 173
Cdd:TIGR01657   75 SN----KSLSNDLQTENAVEGGEEPIYF-------DFRKQRFSYHEKELKIFSPLPYLFKEKS---FGVYSTCAGHSN-- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQY 253
Cdd:TIGR01657  139 GLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQIRKQM 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  254 VMLHDMVatHSTVRVSVCRENEEiEEIFSTDLVPGDVMIIP-LNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPN 332
Cdd:TIGR01657  219 QRLRDMV--HKPQSVIVIRNGKW-VTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKFPIPD 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  333 PSVDvkgmGEEQYSPETHKRHTLFCGTTVIQTRFYTGE-LVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLL 411
Cdd:TIGR01657  296 NGDD----DEDLFLYETSKKHVLFGGTKILQIRPYPGDtGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFIL 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  412 CLVVVAGIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLV 491
Cdd:TIGR01657  372 FLAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVC 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  492 CFDKTGTLTEDGLDLWGIQRVENTR-FLLPEDNVCseMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEE 570
Cdd:TIGR01657  452 CFDKTGTLTEDGLDLRGVQGLSGNQeFLKIVTEDS--SLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  571 ATEEETalHNRIMpTVVRpskqllpepttagnqemelFELPAiYEIGIVRQFPFSSALQRMSVVARTLGEKRMDAYMKGA 650
Cdd:TIGR01657  530 DDESAE--PTSIL-AVVR-------------------TDDPP-QELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGA 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 PEVVASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLEsKLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVL 730
Cdd:TIGR01657  587 PETIQSLCSPETVPSDYQEVLKSYTREGYRVLALAYKELP-KLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVI 665
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  731 EDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYTDSlsqcsESSAIDSEAIPIKLA 810
Cdd:TIGR01657  666 KELKRASIRTVMITGDNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDS-----IPFASTQVEIPYPLG 740
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  811 HDSLEDLEVTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRA 890
Cdd:TIGR01657  741 QDSVEDLLASRYHLAMSGKAFAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQA 820
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  891 HGGISLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLA 970
Cdd:TIGR01657  821 DVGISLSEAEASVAAPFTSKLASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLL 900
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  971 IILVVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIVISVGFQSLGFFWVKQYKVCDPnsdvcnttrsacwnsshl 1050
Cdd:TIGR01657  901 LIFPVALLMSRNKPLKKLSKERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKP------------------ 962
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575 1051 YNGTELDSCKIQNYENTTVFFISSFQYLTVAVAFSKGKPFRQPCYKNYFFVISVIILYVFILFIMLHPVASVDQVLEIMC 1130
Cdd:TIGR01657  963 ENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGPPFREPIYKNKPFVYLLITGLGLLLVLLLDPHPLLGKILQIVP 1042
                         1130
                   ....*....|..
gi 1907117575 1131 VPYQWRIYMLII 1142
Cdd:TIGR01657 1043 LPQEFRSKLLVW 1054
 
Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
14-1142 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1357.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   14 EDEMEIHGYNLCRWKLAMVFVGVICTGGFLLLLLYWLPEWRVKATCVRAAVKDCEVVLLRTTDEFRvwfcakIHFLPVEN 93
Cdd:TIGR01657    1 DKTIGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDPTPNS------GSDYIVEL 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   94 QPnlnaKCLVNEVSNGHAVHLTEENRCEmnkysqsQSQQMRYFTHHSIRYFWNDAIHNFDFLKgldEGVSCASLYEKHsa 173
Cdd:TIGR01657   75 SN----KSLSNDLQTENAVEGGEEPIYF-------DFRKQRFSYHEKELKIFSPLPYLFKEKS---FGVYSTCAGHSN-- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQY 253
Cdd:TIGR01657  139 GLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQIRKQM 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  254 VMLHDMVatHSTVRVSVCRENEEiEEIFSTDLVPGDVMIIP-LNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPN 332
Cdd:TIGR01657  219 QRLRDMV--HKPQSVIVIRNGKW-VTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKFPIPD 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  333 PSVDvkgmGEEQYSPETHKRHTLFCGTTVIQTRFYTGE-LVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLL 411
Cdd:TIGR01657  296 NGDD----DEDLFLYETSKKHVLFGGTKILQIRPYPGDtGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFIL 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  412 CLVVVAGIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLV 491
Cdd:TIGR01657  372 FLAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVC 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  492 CFDKTGTLTEDGLDLWGIQRVENTR-FLLPEDNVCseMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEE 570
Cdd:TIGR01657  452 CFDKTGTLTEDGLDLRGVQGLSGNQeFLKIVTEDS--SLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  571 ATEEETalHNRIMpTVVRpskqllpepttagnqemelFELPAiYEIGIVRQFPFSSALQRMSVVARTLGEKRMDAYMKGA 650
Cdd:TIGR01657  530 DDESAE--PTSIL-AVVR-------------------TDDPP-QELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGA 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 PEVVASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLEsKLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVL 730
Cdd:TIGR01657  587 PETIQSLCSPETVPSDYQEVLKSYTREGYRVLALAYKELP-KLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVI 665
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  731 EDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYTDSlsqcsESSAIDSEAIPIKLA 810
Cdd:TIGR01657  666 KELKRASIRTVMITGDNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDS-----IPFASTQVEIPYPLG 740
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  811 HDSLEDLEVTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRA 890
Cdd:TIGR01657  741 QDSVEDLLASRYHLAMSGKAFAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQA 820
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  891 HGGISLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLA 970
Cdd:TIGR01657  821 DVGISLSEAEASVAAPFTSKLASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLL 900
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  971 IILVVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIVISVGFQSLGFFWVKQYKVCDPnsdvcnttrsacwnsshl 1050
Cdd:TIGR01657  901 LIFPVALLMSRNKPLKKLSKERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKP------------------ 962
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575 1051 YNGTELDSCKIQNYENTTVFFISSFQYLTVAVAFSKGKPFRQPCYKNYFFVISVIILYVFILFIMLHPVASVDQVLEIMC 1130
Cdd:TIGR01657  963 ENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGPPFREPIYKNKPFVYLLITGLGLLLVLLLDPHPLLGKILQIVP 1042
                         1130
                   ....*....|..
gi 1907117575 1131 VPYQWRIYMLII 1142
Cdd:TIGR01657 1043 LPQEFRSKLLVW 1054
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
178-1042 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1233.27  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  178 GMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQYVMLH 257
Cdd:cd07542      1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  258 DMVatHSTVRVSVCRENEEiEEIFSTDLVPGDVMIIPLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPNPSVDV 337
Cdd:cd07542     81 EMV--HFTCPVRVIRDGEW-QTISSSELVPGDILVIPDNGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDS 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  338 KGMgeeQYSPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVA 417
Cdd:cd07542    158 LWS---IYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIA 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  418 GIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTG 497
Cdd:cd07542    235 LIGFIYTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTG 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  498 TLTEDGLDLWGIQRVENTRFLLPEDNVCSE----MLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWIleeate 573
Cdd:cd07542    315 TLTEDGLDLWGVRPVSGNNFGDLEVFSLDLdldsSLPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWS------ 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  574 eetalhnrimptvvrpskqllpepttagnqeMElfelpaiyeigIVRQFPFSSALQRMSVVARTLGEKRMDAYMKGAPEV 653
Cdd:cd07542    389 -------------------------------LE-----------ILRQFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEM 426
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  654 VASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLESKLTWHkvQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDL 733
Cdd:cd07542    427 IASLCKPETVPSNFQEVLNEYTKQGFRVIALAYKALESKTWLL--QKLSREEVESDLEFLGLIVMENRLKPETAPVINEL 504
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  734 HKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHytdslsqcsessaidseaipiklahds 813
Cdd:cd07542    505 NRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVKPEDDDSASLTWT--------------------------- 557
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  814 ledlevtryhfamngksfsvilehfqdlvpkLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGG 893
Cdd:cd07542    558 -------------------------------LLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVG 606
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  894 ISLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIIL 973
Cdd:cd07542    607 ISLSEAEASVAAPFTSKVPDISCVPTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIIT 686
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907117575  974 VVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIVISVGFQSLGFFWVKQ---YKVCDPNSDVCNTTRS 1042
Cdd:cd07542    687 PIAVFMSRTGAYPKLSSKRPPASLVSPPVLVSLLGQIVLILLFQVIGFLIVRQqpwYIPPEPTVDKANTDNS 758
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
174-1172 2.04e-78

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 277.76  E-value: 2.04e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIA-VKVPSVFKLLIKEVLNPFYIFQLFSVIL-WSVDEYyyyALAIVIMSVV---SIIS---- 244
Cdd:COG0474     26 GLSSEEAARRLARYGPNELPeEKKRSLLRRFLEQFKNPLILILLAAAVIsALLGDW---VDAIVILAVVllnAIIGfvqe 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  245 -----SLYSIRKqyvmlhdMVATHSTVRvsvcRENEEIEeIFSTDLVPGDVMIIPLnGTVMPCDAVLINGT-CIVNESML 318
Cdd:COG0474    103 yraekALEALKK-------LLAPTARVL----RDGKWVE-IPAEELVPGDIVLLEA-GDRVPADLRLLEAKdLQVDESAL 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  319 TGESVPVTKTnlPNPSVDVKGMGEEqyspethkRHTLFCGTTVIQtrfytGELvKAIVVRTGFSTSKGQLVRSI--LYPK 396
Cdd:COG0474    170 TGESVPVEKS--ADPLPEDAPLGDR--------GNMVFMGTLVTS-----GRG-TAVVVATGMNTEFGKIAKLLqeAEEE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  397 PTDF-----KLYRdaYLFLLCLVVVAGIGFIYtiinsILNEKEVQEIIIKSldiITITV---PPALPAAMTA----G--- 461
Cdd:COG0474    234 KTPLqkqldRLGK--LLAIIALVLAALVFLIG-----LLRGGPLLEALLFA---VALAVaaiPEGLPAVVTItlalGaqr 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  462 ------IVyaqRRLKKVGIFcispqrinicGQLNLVCFDKTGTLTEDGLDLwgiQRVENTRFLLPEDNVCSEMLvkSQFV 535
Cdd:COG0474    304 makrnaIV---RRLPAVETL----------GSVTVICTDKTGTLTQNKMTV---ERVYTGGGTYEVTGEFDPAL--EELL 365
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  536 ACMATCHSLTKIEGVLSGDPLDLKMFEAigwileeateeetalhnrimptvvrpskqllpepttAGNQEMELFELPAIYE 615
Cdd:COG0474    366 RAAALCSDAQLEEETGLGDPTEGALLVA------------------------------------AAKAGLDVEELRKEYP 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  616 IgiVRQFPFSSALQRMSVVARTLGEKRMdAYMKGAPEVVASLCK-----PETVPVD------FEKVLEDYTKQGFRVIAL 684
Cdd:COG0474    410 R--VDEIPFDSERKRMSTVHEDPDGKRL-LIVKGAPEVVLALCTrvltgGGVVPLTeedraeILEAVEELAAQGLRVLAV 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  685 AHRKLESkltwhkVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQ 764
Cdd:COG0474    487 AYKELPA------DPELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDG 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  765 DKVIIAEALppkdgkvakinwhytDSLSqcsessaiDSEaipiklahdsledlevtryhfamngksfsvilehFQDLVPk 844
Cdd:COG0474    561 DRVLTGAEL---------------DAMS--------DEE----------------------------------LAEAVE- 582
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  845 lmlHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSE------LEASvaspftsktpSIscV- 917
Cdd:COG0474    583 ---DVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAADIGIAMGItgtdvaKEAA----------DI--Vl 647
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  918 --PNL------IREGRAalmtsfcVF----KFmalysiIQY-FS------VTLLYSILSNLGD----FQFLFIDLAIILV 974
Cdd:COG0474    648 ldDNFativaaVEEGRR-------IYdnirKF------IKYlLSsnfgevLSVLLASLLGLPLpltpIQILWINLVTDGL 714
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  975 VVFTMSLNPAWKElVAQRPP----SGLISGALLFSVLSQIVISVGFqSLGFFWVkqykvcdpnsdvcnttrsacwnssHL 1050
Cdd:COG0474    715 PALALGFEPVEPD-VMKRPPrwpdEPILSRFLLLRILLLGLLIAIF-TLLTFAL------------------------AL 768
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575 1051 YNGTELDSCkiqnyenTTVFFISS--FQYLTVAVAFSKGKP-FRQPCYKNYFFVISVIILYVFILFIMLHPVASvdQVLE 1127
Cdd:COG0474    769 ARGASLALA-------RTMAFTTLvlSQLFNVFNCRSERRSfFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQ--ALFG 839
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 1907117575 1128 imCVPYQWrIYMLIIVLINAFVSITVEsffldtvLWKVVFNRDKQ 1172
Cdd:COG0474    840 --TVPLPL-SDWLLILGLALLYLLLVE-------LVKLLRRRFGR 874
E1-E2_ATPase pfam00122
E1-E2 ATPase;
258-471 1.10e-37

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 139.63  E-value: 1.10e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  258 DMVATHSTVRvsvcrENEEIEEIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCIVNESMLTGESVPVTKtnlpnpsvdv 337
Cdd:pfam00122    1 SLLPPTATVL-----RDGTEEEVPADELVPGDIVLLK-PGERVPADGRIVEGSASVDESLLTGESLPVEK---------- 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  338 kgmgeeqyspetHKRHTLFCGTTVIQtrfytGELvKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVA 417
Cdd:pfam00122   65 ------------KKGDMVYSGTVVVS-----GSA-KAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVV 126
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907117575  418 GIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKK 471
Cdd:pfam00122  127 LLIALAVFLLWLFVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAK 180
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
171-895 1.15e-22

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 105.11  E-value: 1.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  171 HSAGLTQGMHAYRKLIYGVNEIA-VKVPSVFKLLIKEVLNPF-YIFQLFSVILWSVDeyYYYAL----------AIVIMS 238
Cdd:PRK15122    42 HRQGLTEEDAAERLQRYGPNEVAhEKPPHALVQLLQAFNNPFiYVLMVLAAISFFTD--YWLPLrrgeetdltgVIIILT 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  239 VVSIiSSL------YSIRKQYVMLHDMVATHSTV--RVSVCREnEEIEEIFSTDLVPGDvmIIPLN-GTVMPCDAVLING 309
Cdd:PRK15122   120 MVLL-SGLlrfwqeFRSNKAAEALKAMVRTTATVlrRGHAGAE-PVRREIPMRELVPGD--IVHLSaGDMIPADVRLIES 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  310 -TCIVNESMLTGESVPVTKtnlpnpsVDVKGMGEEQYSPETHK--------RHTLFCGTTVIQTRfytgelVKAIVVRTG 380
Cdd:PRK15122   196 rDLFISQAVLTGEALPVEK-------YDTLGAVAGKSADALADdegslldlPNICFMGTNVVSGT------ATAVVVATG 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  381 FSTSKGQLVRSILYPKP-TDFK---------LYRdaylFLLCLVVVAgigfiyTIINSiLNEKEVQEIIIKSLDIITITV 450
Cdd:PRK15122   263 SRTYFGSLAKSIVGTRAqTAFDrgvnsvswlLIR----FMLVMVPVV------LLING-FTKGDWLEALLFALAVAVGLT 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  451 PPALPAAMTA----GIVYAQRRlkKVGIfcispQRINIC---GQLNLVCFDKTGTLTEDgldlwgiqrventRFLLPedn 523
Cdd:PRK15122   332 PEMLPMIVSSnlakGAIAMARR--KVVV-----KRLNAIqnfGAMDVLCTDKTGTLTQD-------------RIILE--- 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  524 vcsemlvksqfvacmatcHSLtKIEGVLSGDPLDLkmfeaiGWIleeateeeTALHNRIMptvvrpsKQLLPEPTTAGNQ 603
Cdd:PRK15122   389 ------------------HHL-DVSGRKDERVLQL------AWL--------NSFHQSGM-------KNLMDQAVVAFAE 428
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  604 EMELFELPAIYeiGIVRQFPFSSALQRMSV-VARTLGEKRMdaYMKGAPEVVASLCK-----PETVPVDF---EKVL--- 671
Cdd:PRK15122   429 GNPEIVKPAGY--RKVDELPFDFVRRRLSVvVEDAQGQHLL--ICKGAVEEMLAVAThvrdgDTVRPLDEarrERLLala 504
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  672 EDYTKQGFRVIALAHRKLESkltwHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTA 751
Cdd:PRK15122   505 EAYNADGFRVLLVATREIPG----GESRAQYSTADERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVT 580
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  752 VSVARDCGMilpqdkviiaEALPPKDGKvakinwhytdslsqcsessaiDSEAipiklahdsLEDLEVTRyhfamngksf 831
Cdd:PRK15122   581 AKICREVGL----------EPGEPLLGT---------------------EIEA---------MDDAALAR---------- 610
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907117575  832 svilehfqdlvpkLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGIS 895
Cdd:PRK15122   611 -------------EVEERTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGIS 661
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
164-222 1.39e-04

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 41.41  E-value: 1.39e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   164 CASLYEKHSAGLTQGMHAYRKLIYGVNEIAVKV-PSVFKLLIKEVLNPFYIFQLFSVILW 222
Cdd:smart00831   13 LERLQTDLEKGLSSEEAARRLERYGPNELPPPKkTSPLLRFLRQFHNPLIYILLAAAVLS 72
 
Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
14-1142 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1357.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   14 EDEMEIHGYNLCRWKLAMVFVGVICTGGFLLLLLYWLPEWRVKATCVRAAVKDCEVVLLRTTDEFRvwfcakIHFLPVEN 93
Cdd:TIGR01657    1 DKTIGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDPTPNS------GSDYIVEL 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   94 QPnlnaKCLVNEVSNGHAVHLTEENRCEmnkysqsQSQQMRYFTHHSIRYFWNDAIHNFDFLKgldEGVSCASLYEKHsa 173
Cdd:TIGR01657   75 SN----KSLSNDLQTENAVEGGEEPIYF-------DFRKQRFSYHEKELKIFSPLPYLFKEKS---FGVYSTCAGHSN-- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQY 253
Cdd:TIGR01657  139 GLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQIRKQM 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  254 VMLHDMVatHSTVRVSVCRENEEiEEIFSTDLVPGDVMIIP-LNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPN 332
Cdd:TIGR01657  219 QRLRDMV--HKPQSVIVIRNGKW-VTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKFPIPD 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  333 PSVDvkgmGEEQYSPETHKRHTLFCGTTVIQTRFYTGE-LVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLL 411
Cdd:TIGR01657  296 NGDD----DEDLFLYETSKKHVLFGGTKILQIRPYPGDtGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFIL 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  412 CLVVVAGIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLV 491
Cdd:TIGR01657  372 FLAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVC 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  492 CFDKTGTLTEDGLDLWGIQRVENTR-FLLPEDNVCseMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEE 570
Cdd:TIGR01657  452 CFDKTGTLTEDGLDLRGVQGLSGNQeFLKIVTEDS--SLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  571 ATEEETalHNRIMpTVVRpskqllpepttagnqemelFELPAiYEIGIVRQFPFSSALQRMSVVARTLGEKRMDAYMKGA 650
Cdd:TIGR01657  530 DDESAE--PTSIL-AVVR-------------------TDDPP-QELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGA 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 PEVVASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLEsKLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVL 730
Cdd:TIGR01657  587 PETIQSLCSPETVPSDYQEVLKSYTREGYRVLALAYKELP-KLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVI 665
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  731 EDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYTDSlsqcsESSAIDSEAIPIKLA 810
Cdd:TIGR01657  666 KELKRASIRTVMITGDNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDS-----IPFASTQVEIPYPLG 740
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  811 HDSLEDLEVTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRA 890
Cdd:TIGR01657  741 QDSVEDLLASRYHLAMSGKAFAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQA 820
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  891 HGGISLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLA 970
Cdd:TIGR01657  821 DVGISLSEAEASVAAPFTSKLASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLL 900
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  971 IILVVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIVISVGFQSLGFFWVKQYKVCDPnsdvcnttrsacwnsshl 1050
Cdd:TIGR01657  901 LIFPVALLMSRNKPLKKLSKERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKP------------------ 962
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575 1051 YNGTELDSCKIQNYENTTVFFISSFQYLTVAVAFSKGKPFRQPCYKNYFFVISVIILYVFILFIMLHPVASVDQVLEIMC 1130
Cdd:TIGR01657  963 ENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGPPFREPIYKNKPFVYLLITGLGLLLVLLLDPHPLLGKILQIVP 1042
                         1130
                   ....*....|..
gi 1907117575 1131 VPYQWRIYMLII 1142
Cdd:TIGR01657 1043 LPQEFRSKLLVW 1054
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
178-1042 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1233.27  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  178 GMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQYVMLH 257
Cdd:cd07542      1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  258 DMVatHSTVRVSVCRENEEiEEIFSTDLVPGDVMIIPLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPNPSVDV 337
Cdd:cd07542     81 EMV--HFTCPVRVIRDGEW-QTISSSELVPGDILVIPDNGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDS 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  338 KGMgeeQYSPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVA 417
Cdd:cd07542    158 LWS---IYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIA 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  418 GIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTG 497
Cdd:cd07542    235 LIGFIYTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTG 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  498 TLTEDGLDLWGIQRVENTRFLLPEDNVCSE----MLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWIleeate 573
Cdd:cd07542    315 TLTEDGLDLWGVRPVSGNNFGDLEVFSLDLdldsSLPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWS------ 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  574 eetalhnrimptvvrpskqllpepttagnqeMElfelpaiyeigIVRQFPFSSALQRMSVVARTLGEKRMDAYMKGAPEV 653
Cdd:cd07542    389 -------------------------------LE-----------ILRQFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEM 426
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  654 VASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLESKLTWHkvQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDL 733
Cdd:cd07542    427 IASLCKPETVPSNFQEVLNEYTKQGFRVIALAYKALESKTWLL--QKLSREEVESDLEFLGLIVMENRLKPETAPVINEL 504
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  734 HKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHytdslsqcsessaidseaipiklahds 813
Cdd:cd07542    505 NRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVKPEDDDSASLTWT--------------------------- 557
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  814 ledlevtryhfamngksfsvilehfqdlvpkLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGG 893
Cdd:cd07542    558 -------------------------------LLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVG 606
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  894 ISLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIIL 973
Cdd:cd07542    607 ISLSEAEASVAAPFTSKVPDISCVPTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIIT 686
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907117575  974 VVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIVISVGFQSLGFFWVKQ---YKVCDPNSDVCNTTRS 1042
Cdd:cd07542    687 PIAVFMSRTGAYPKLSSKRPPASLVSPPVLVSLLGQIVLILLFQVIGFLIVRQqpwYIPPEPTVDKANTDNS 758
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
179-1043 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 1061.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  179 MHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQYVmlHD 258
Cdd:cd02082      1 RVDQLLAYYGKNEIEINVPSFLTLMWREFKKPFNFFQYFGVILWGIDEYVYYAITVVFMTTINSLSCIYIRGVMQK--EL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  259 MVATHSTVRVSVCRENEEIEEIFSTDLVPGDVMIIPLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPNPSVDVK 338
Cdd:cd02082     79 KDACLNNTSVIVQRHGYQEITIASNMIVPGDIVLIKRREVTLPCDCVLLEGSCIVTEAMLTGESVPIGKCQIPTDSHDDV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  339 gmgeeQYSPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVAG 418
Cdd:cd02082    159 -----LFKYESSKSHTLFQGTQVMQIIPPEDDILKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKFTLLLATLAL 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  419 IGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGT 498
Cdd:cd02082    234 IGFLYTLIRLLDIELPPLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGT 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  499 LTEDGLDLWGIQRVENTRFLLPEDNVCSemLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILeeateeetal 578
Cdd:cd02082    314 LTEDKLDLIGYQLKGQNQTFDPIQCQDP--NNISIEHKLFAICHSLTKINGKLLGDPLDVKMAEASTWDL---------- 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  579 hnrimptvvrpskqllpeptTAGNQEMELFELPAIYEIGIVRQFPFSSALQRMSVVARTLG----EKRMDAYMKGAPEVV 654
Cdd:cd02082    382 --------------------DYDHEAKQHYSKSGTKRFYIIQVFQFHSALQRMSVVAKEVDmitkDFKHYAFIKGAPEKI 441
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  655 ASLCkpETVPVDFEKVLEDYTKQGFRVIALAHRKLESKLTWHKvQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLH 734
Cdd:cd02082    442 QSLF--SHVPSDEKAQLSTLINEGYRVLALGYKELPQSEIDAF-LDLSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFK 518
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  735 KANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHytdslsqcsessaidseaipiklahdsl 814
Cdd:cd02082    519 EACYRIVMITGDNPLTALKVAQELEIINRKNPTIIIHLLIPEIQKDNSTQWI---------------------------- 570
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  815 edlevtryhfamngksfsvilehfqdlvpkLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGI 894
Cdd:cd02082    571 ------------------------------LIIHTNVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGI 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  895 SLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQflfidlaiilv 974
Cdd:cd02082    621 SLAEADASFASPFTSKSTSISCVKRVILEGRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYSSSG----------- 689
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  975 vVFTMSLNPAWKELVAQRPPS-------------------GLISGALLFSVLSQIVISVGFQSLGF------FWVKQ--- 1026
Cdd:cd02082    690 -QMDWQLLAAGYFLVYLRLGCntplkklekddnlfsiynvTSVLFGFTLHILSIVGCVESLQASPIykevnsLDAENnfq 768
                          890
                   ....*....|....*..
gi 1907117575 1027 YKVCDPNSDVCNTTRSA 1043
Cdd:cd02082    769 FETQHNTVLAFNILINF 785
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
187-1092 2.10e-154

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 483.42  E-value: 2.10e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  187 YGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQYVMLHDMvaTHSTV 266
Cdd:cd07543      9 YGKNKFDIPVPTFSELFKEHAVAPFFVFQVFCVGLWCLDEYWYYSLFTLFMLVAFEATLVFQRMKNLSEFRTM--GNKPY 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  267 RVSVCRENEEIEeIFSTDLVPGDVMII--PLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPN-PSVDVKGMGEE 343
Cdd:cd07543     87 TIQVYRDGKWVP-ISSDELLPGDLVSIgrSAEDNLVPCDLLLLRGSCIVNEAMLTGESVPLMKEPIEDrDPEDVLDDDGD 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  344 qyspetHKRHTLFCGTTVIQTRFYTGELVK-------AIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVV 416
Cdd:cd07543    166 ------DKLHVLFGGTKVVQHTPPGKGGLKppdggclAYVLRTGFETSQGKLLRTILFSTERVTANNLETFIFILFLLVF 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  417 AGIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKT 496
Cdd:cd07543    240 AIAAAAYVWIEGTKDGRSRYKLFLECTLILTSVVPPELPMELSLAVNTSLIALAKLYIFCTEPFRIPFAGKVDICCFDKT 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  497 GTLTEDGLDLWGIQRVENTRFLLPednvcSEMLVKSQFVACMATCHSLTKI-EGVLSGDPLDLKMFEAIGWileeateee 575
Cdd:cd07543    320 GTLTSDDLVVEGVAGLNDGKEVIP-----VSSIEPVETILVLASCHSLVKLdDGKLVGDPLEKATLEAVDW--------- 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  576 talhnrimpTVVRPSKQLLPEPTTAGnqemelfelpaiyeIGIVRQFPFSSALQRMSVVAR-----TLGEKRMdAYMKGA 650
Cdd:cd07543    386 ---------TLTKDEKVFPRSKKTKG--------------LKIIQRFHFSSALKRMSVVASykdpgSTDLKYI-VAVKGA 441
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 PEVVASLCKpeTVPVDFEKVLEDYTKQGFRVIALAHRKLEsKLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVL 730
Cdd:cd07543    442 PETLKSMLS--DVPADYDEVYKEYTRQGSRVLALGYKELG-HLTKQQARDYKREDVESDLTFAGFIVFSCPLKPDSKETI 518
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  731 EDLHKANIRTVMVTGDNMLTAVSVARDCGMIlpQDKVIIAEalPPKDGKVAKinWhytdslsqcsessaidseaipikla 810
Cdd:cd07543    519 KELNNSSHRVVMITGDNPLTACHVAKELGIV--DKPVLILI--LSEEGKSNE--W------------------------- 567
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  811 hdsledlevtryhfamngksfsvilehfqdlvpKLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRA 890
Cdd:cd07543    568 ---------------------------------KLIPHVKVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHA 614
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  891 HGGISLSEL-EASVASPFTSKTPSISCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQflfIDL 969
Cdd:cd07543    615 HVGVALLKLgDASIAAPFTSKLSSVSCVCHIIKQGRCTLVTTLQMFKILALNCLISAYSLSVLYLDGVKFGDVQ---ATI 691
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  970 AIILVVVFTMSLNPA--WKELVAQRPPSGLISGALLFSVLSQIVISvgFQSLGFFWVKQYKVCDPNSDVcnttrsacwns 1047
Cdd:cd07543    692 SGLLLAACFLFISRSkpLETLSKERPLPNIFNLYTILSVLLQFAVH--FVSLVYITGEAKELEPPREEV----------- 758
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*.
gi 1907117575 1048 shlyngtELDSCKIQNYENTTVFFIS-SFQYLTVAVAFsKGKPFRQ 1092
Cdd:cd07543    759 -------DLEKEFEPSLVNSTVYILSmAQQVATFAVNY-KGRPFRE 796
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
234-961 1.62e-115

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 371.26  E-value: 1.62e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  234 IVIMSVVSIISSLYS-------IRKqyvmLHDMVATHSTVRVsvcrENEEIEEIFSTDLVPGDVMIIPlNGTVMPCDAVL 306
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQklkaedaLRS----LKDSLVNTATVLV----LRNGWKEISSKDLVPGDVVLVK-SGDTVPADGVL 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  307 INGTCIVNESMLTGESVPVTKTnlpnpsvdvkgmgEEQYSPETHKRHTLFCGTTVIQTRFY---TGELVKAIVVRTGFST 383
Cdd:TIGR01494   73 LSGSAFVDESSLTGESLPVLKT-------------ALPDGDAVFAGTINFGGTLIVKVTATgilTTVGKIAVVVYTGFST 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  384 skgqlvRSILYPKPTDFKLYrdayLFLLCLVVVAGIGFIYTIInSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIV 463
Cdd:TIGR01494  140 ------KTPLQSKADKFENF----IFILFLLLLALAVFLLLPI-GGWDGNSIYKAILRALAVLVIAIPCALPLAVSVALA 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  464 YAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGIQRventrfllpeDNVCSEMLVKSQFVACMATCHs 543
Cdd:TIGR01494  209 VGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVII----------IGGVEEASLALALLAASLEYL- 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  544 ltkiegvlSGDPLDLKMFEAIGWILEEATeeetalhnrimptvvrpskqllpepttaGNQEMElfelpaiyeigIVRQFP 623
Cdd:TIGR01494  278 --------SGHPLERAIVKSAEGVIKSDE----------------------------INVEYK-----------ILDVFP 310
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  624 FSSALQRMSVVARTLGEKRMdAYMKGAPEVVASLCKPETvpvDFEKVLEDYTKQGFRVIALAHRKLeskltwhkvqhisr 703
Cdd:TIGR01494  311 FSSVLKRMGVIVEGANGSDL-LFVKGAPEFVLERCNNEN---DYDEKVDEYARQGLRVLAFASKKL-------------- 372
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  704 daiENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpqdkviiaealppkdgkvaki 783
Cdd:TIGR01494  373 ---PDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGI----------------------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  784 nwhytdslsqcsessaidseaipiklahdsledlevtryhfamngksfsvilehfqdlvpklmlhgTVFARMAPDQKTQL 863
Cdd:TIGR01494  427 ------------------------------------------------------------------DVFARVKPEEKAAI 440
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  864 VEALQNVDYFVGMCGDGANDCGALKRAHGGISLSELEASVAS---PFTSktPSISCVPNLIREGRAALMTSFCVFKFMAL 940
Cdd:TIGR01494  441 VEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSGDVAKAAadiVLLD--DDLSTIVEAVKEGRKTFSNIKKNIFWAIA 518
                          730       740
                   ....*....|....*....|.
gi 1907117575  941 YSIIQYFSVtLLYSILSNLGD 961
Cdd:TIGR01494  519 YNLILIPLA-LLLIVIILLPP 538
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
174-1172 2.04e-78

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 277.76  E-value: 2.04e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIA-VKVPSVFKLLIKEVLNPFYIFQLFSVIL-WSVDEYyyyALAIVIMSVV---SIIS---- 244
Cdd:COG0474     26 GLSSEEAARRLARYGPNELPeEKKRSLLRRFLEQFKNPLILILLAAAVIsALLGDW---VDAIVILAVVllnAIIGfvqe 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  245 -----SLYSIRKqyvmlhdMVATHSTVRvsvcRENEEIEeIFSTDLVPGDVMIIPLnGTVMPCDAVLINGT-CIVNESML 318
Cdd:COG0474    103 yraekALEALKK-------LLAPTARVL----RDGKWVE-IPAEELVPGDIVLLEA-GDRVPADLRLLEAKdLQVDESAL 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  319 TGESVPVTKTnlPNPSVDVKGMGEEqyspethkRHTLFCGTTVIQtrfytGELvKAIVVRTGFSTSKGQLVRSI--LYPK 396
Cdd:COG0474    170 TGESVPVEKS--ADPLPEDAPLGDR--------GNMVFMGTLVTS-----GRG-TAVVVATGMNTEFGKIAKLLqeAEEE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  397 PTDF-----KLYRdaYLFLLCLVVVAGIGFIYtiinsILNEKEVQEIIIKSldiITITV---PPALPAAMTA----G--- 461
Cdd:COG0474    234 KTPLqkqldRLGK--LLAIIALVLAALVFLIG-----LLRGGPLLEALLFA---VALAVaaiPEGLPAVVTItlalGaqr 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  462 ------IVyaqRRLKKVGIFcispqrinicGQLNLVCFDKTGTLTEDGLDLwgiQRVENTRFLLPEDNVCSEMLvkSQFV 535
Cdd:COG0474    304 makrnaIV---RRLPAVETL----------GSVTVICTDKTGTLTQNKMTV---ERVYTGGGTYEVTGEFDPAL--EELL 365
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  536 ACMATCHSLTKIEGVLSGDPLDLKMFEAigwileeateeetalhnrimptvvrpskqllpepttAGNQEMELFELPAIYE 615
Cdd:COG0474    366 RAAALCSDAQLEEETGLGDPTEGALLVA------------------------------------AAKAGLDVEELRKEYP 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  616 IgiVRQFPFSSALQRMSVVARTLGEKRMdAYMKGAPEVVASLCK-----PETVPVD------FEKVLEDYTKQGFRVIAL 684
Cdd:COG0474    410 R--VDEIPFDSERKRMSTVHEDPDGKRL-LIVKGAPEVVLALCTrvltgGGVVPLTeedraeILEAVEELAAQGLRVLAV 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  685 AHRKLESkltwhkVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQ 764
Cdd:COG0474    487 AYKELPA------DPELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDG 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  765 DKVIIAEALppkdgkvakinwhytDSLSqcsessaiDSEaipiklahdsledlevtryhfamngksfsvilehFQDLVPk 844
Cdd:COG0474    561 DRVLTGAEL---------------DAMS--------DEE----------------------------------LAEAVE- 582
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  845 lmlHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSE------LEASvaspftsktpSIscV- 917
Cdd:COG0474    583 ---DVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAADIGIAMGItgtdvaKEAA----------DI--Vl 647
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  918 --PNL------IREGRAalmtsfcVF----KFmalysiIQY-FS------VTLLYSILSNLGD----FQFLFIDLAIILV 974
Cdd:COG0474    648 ldDNFativaaVEEGRR-------IYdnirKF------IKYlLSsnfgevLSVLLASLLGLPLpltpIQILWINLVTDGL 714
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  975 VVFTMSLNPAWKElVAQRPP----SGLISGALLFSVLSQIVISVGFqSLGFFWVkqykvcdpnsdvcnttrsacwnssHL 1050
Cdd:COG0474    715 PALALGFEPVEPD-VMKRPPrwpdEPILSRFLLLRILLLGLLIAIF-TLLTFAL------------------------AL 768
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575 1051 YNGTELDSCkiqnyenTTVFFISS--FQYLTVAVAFSKGKP-FRQPCYKNYFFVISVIILYVFILFIMLHPVASvdQVLE 1127
Cdd:COG0474    769 ARGASLALA-------RTMAFTTLvlSQLFNVFNCRSERRSfFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQ--ALFG 839
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 1907117575 1128 imCVPYQWrIYMLIIVLINAFVSITVEsffldtvLWKVVFNRDKQ 1172
Cdd:COG0474    840 --TVPLPL-SDWLLILGLALLYLLLVE-------LVKLLRRRFGR 874
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
174-896 3.80e-51

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 192.83  E-value: 3.80e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEI-AVKVPSVFKLLIKEVLNPFYIFQLF----SVILWSvdeyyyYALAIVIMSVV---SIISS 245
Cdd:cd02089      1 GLSEEEAERRLAKYGPNELvEKKKRSPWKKFLEQFKDFMVIVLLAaaviSGVLGE------YVDAIVIIAIVilnAVLGF 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  246 LYSIRKQYVM--LHDMVATHSTVRvsvcRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCI-VNESMLTGES 322
Cdd:cd02089     75 VQEYKAEKALaaLKKMSAPTAKVL----RDGKKQE-IPARELVPGDIVLLE-AGDYVPADGRLIESASLrVEESSLTGES 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  323 VPVTKTNLPNPSVDVkgmgeeqysPETHKRHTLFCGTTVIQTRfytgelVKAIVVRTGFSTSKGQ---LVRSILyPKPTD 399
Cdd:cd02089    149 EPVEKDADTLLEEDV---------PLGDRKNMVFSGTLVTYGR------GRAVVTATGMNTEMGKiatLLEETE-EEKTP 212
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  400 FKLYRDAYLFLLCLVVVAGIGFIYTIinSILNEKEVQEIIIKSLDIITITVPPALPAAMTagIVYA---QRRLKKVGIFC 476
Cdd:cd02089    213 LQKRLDQLGKRLAIAALIICALVFAL--GLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVT--IVLAlgvQRMAKRNAIIR 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  477 ISPQrINICGQLNLVCFDKTGTLTEdgldlwgiqrventrfllpednvcSEMLVksqfvacmatchslTKIegVLSGDPL 556
Cdd:cd02089    289 KLPA-VETLGSVSVICSDKTGTLTQ------------------------NKMTV--------------EKI--YTIGDPT 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  557 DLKMFEAigwileeateeetalhnrimptvvrpskqllpepTTAGNQEMELFE--LPAIYEIgivrqfPFSSALQRMSVV 634
Cdd:cd02089    328 ETALIRA----------------------------------ARKAGLDKEELEkkYPRIAEI------PFDSERKLMTTV 367
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  635 ARTLGEKRMdaYMKGAPEVVASLCK-----PETVPVD------FEKVLEDYTKQGFRVIALAHRKLESKLTwhkvqhISR 703
Cdd:cd02089    368 HKDAGKYIV--FTKGAPDVLLPRCTyiyinGQVRPLTeedrakILAVNEEFSEEALRVLAVAYKPLDEDPT------ESS 439
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  704 DAIENNMDFMGLIIMQNKLKQET-PAVLEdLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALppkdgkvak 782
Cdd:cd02089    440 EDLENDLIFLGLVGMIDPPRPEVkDAVAE-CKKAGIKTVMITGDHKLTARAIAKELGILEDGDKALTGEEL--------- 509
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  783 inwhytDSLSQcsessaidseaipiklahdslEDLEvtryhfamngKSFSVIlehfqdlvpklmlhgTVFARMAPDQKTQ 862
Cdd:cd02089    510 ------DKMSD---------------------EELE----------KKVEQI---------------SVYARVSPEHKLR 537
                          730       740       750
                   ....*....|....*....|....*....|....
gi 1907117575  863 LVEALQNVDYFVGMCGDGANDCGALKRAHGGISL 896
Cdd:cd02089    538 IVKALQRKGKIVAMTGDGVNDAPALKAADIGVAM 571
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
174-896 3.97e-50

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 192.09  E-value: 3.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVP-SVFKLLIKEVLNPF-YIFQLFSVILWSVDEYYYyalAIVIMSVVSIIS------- 244
Cdd:cd02080      1 GLTSEEAAERLERYGPNRLPEKKTkSPLLRFLRQFNNPLiYILLAAAVVTAFLGHWVD---AIVIFGVVLINAiigyiqe 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  245 -----SLYSIRKqyvmlhdMVATHSTVRvsvcRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCI-VNESML 318
Cdd:cd02080     78 gkaekALAAIKN-------MLSPEATVL----RDGKKLT-IDAEELVPGDIVLLE-AGDKVPADLRLIEARNLqIDESAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  319 TGESVPVTKTNLPNPsvdvkgmgEEqySPETHKRHTLFCGTTVIQTRfytgelVKAIVVRTGFSTSKGQLVRSILYPKPT 398
Cdd:cd02080    145 TGESVPVEKQEGPLE--------ED--TPLGDRKNMAYSGTLVTAGS------ATGVVVATGADTEIGRINQLLAEVEQL 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  399 DFKLYRD----AYLFLLCLVVVAGIGFIYTIinsILNEKEVQEIIIKSLDIITITVPPALPAAMTagIVYA---QRRLKK 471
Cdd:cd02080    209 ATPLTRQiakfSKALLIVILVLAALTFVFGL---LRGDYSLVELFMAVVALAVAAIPEGLPAVIT--ITLAigvQRMAKR 283
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  472 VGIFCISPQrINICGQLNLVCFDKTGTLTEDgldlwgiqrventrfllpednvcsEMLVKSQFVACMATchSLTKIEGV- 550
Cdd:cd02080    284 NAIIRRLPA-VETLGSVTVICSDKTGTLTRN------------------------EMTVQAIVTLCNDA--QLHQEDGHw 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  551 -LSGDPLDLKMfeaigwileeateeetalhnrimptVVRPSKqllpeptTAGNQEMELFELPAIYEIgivrqfPFSSALQ 629
Cdd:cd02080    337 kITGDPTEGAL-------------------------LVLAAK-------AGLDPDRLASSYPRVDKI------PFDSAYR 378
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  630 RMSVVARTLGEKRMdaYMKGAPEVVASLCKPET-----VPVD---FEKVLEDYTKQGFRVIALAHRKLEskltwHKVQHI 701
Cdd:cd02080    379 YMATLHRDDGQRVI--YVKGAPERLLDMCDQELldggvSPLDrayWEAEAEDLAKQGLRVLAFAYREVD-----SEVEEI 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  702 SRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGmILPQDKVIIAEALppkdgkva 781
Cdd:cd02080    452 DHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLG-LGDGKKVLTGAEL-------- 522
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  782 kinwhytdslsqcsessaidseaipiklahDSLEDlevtryhfamngksfsvilEHFQDLVpklmLHGTVFARMAPDQKT 861
Cdd:cd02080    523 ------------------------------DALDD-------------------EELAEAV----DEVDVFARTSPEHKL 549
                          730       740       750
                   ....*....|....*....|....*....|....*
gi 1907117575  862 QLVEALQNVDYFVGMCGDGANDCGALKRAHGGISL 896
Cdd:cd02080    550 RLVRALQARGEVVAMTGDGVNDAPALKQADIGIAM 584
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
174-970 1.76e-49

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 191.13  E-value: 1.76e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEI-AVKVPSVFKLLIKEVLNPFYIFQLFSVIL-WSVDEYY---YYALAIVIMSVVSIISSlYS 248
Cdd:cd02086      1 GLTNDEAERRLKEYGENELeGDTGVSAWKILLRQVANAMTLVLIIAMALsFAVKDWIeggVIAAVIALNVIVGFIQE-YK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  249 IRKQYVMLHDMVATHSTVRvsvcrENEEIEEIFSTDLVPGDVMIIPLnGTVMPCDAVLINGTCI-VNESMLTGESVPVTK 327
Cdd:cd02086     80 AEKTMDSLRNLSSPNAHVI-----RSGKTETISSKDVVPGDIVLLKV-GDTVPADLRLIETKNFeTDEALLTGESLPVIK 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  328 TNLPnpsvdVKGMGEEqySPETHKRHTLFCGTTVIQTRfytgelVKAIVVRTGFSTSKGQLVRSI------LYPKPTDFK 401
Cdd:cd02086    154 DAEL-----VFGKEED--VSVGDRLNLAYSSSTVTKGR------AKGIVVATGMNTEIGKIAKALrgkgglISRDRVKSW 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  402 LYRDAYL-------FLLCLV-------------VVAGIGFIYTIINSILNEKEV-QEIIIKSLDIITITVPPALPAAMTA 460
Cdd:cd02086    221 LYGTLIVtwdavgrFLGTNVgtplqrklsklayLLFFIAVILAIIVFAVNKFDVdNEVIIYAIALAISMIPESLVAVLTI 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  461 GIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEdgldlwgiqrventrfllpednvcSEMLVKSQFVACmAT 540
Cdd:cd02086    301 TMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQ------------------------GKMVVRQVWIPA-AL 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  541 CHSLT------KIEGVLSGDPLDLkmfeAIgwileeateeetalhnRIMPTVVRPSKQLLPEPTTAGNQEmelfelpaiy 614
Cdd:cd02086    356 CNIATvfkdeeTDCWKAHGDPTEI----AL----------------QVFATKFDMGKNALTKGGSAQFQH---------- 405
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  615 eigiVRQFPFSSALQRMSVVARTLGEKRMDAYMKGAPEVVASLC-----KPETVPVDFE------KVLEDYTKQGFRVIA 683
Cdd:cd02086    406 ----VAEFPFDSTVKRMSVVYYNNQAGDYYAYMKGAVERVLECCssmygKDGIIPLDDEfrktiiKNVESLASQGLRVLA 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  684 LAHRKLESKLTW---HKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGm 760
Cdd:cd02086    482 FASRSFTKAQFNddqLKNITLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVG- 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  761 ILPQDKViiaealppkdgkvakinwhytdslsqcSESSAIDSEAIPIKLAHDSLEDLEVtryhfamngksfsvilehfqD 840
Cdd:cd02086    561 ILPPNSY---------------------------HYSQEIMDSMVMTASQFDGLSDEEV--------------------D 593
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  841 LVPKLMLhgtVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSELEASVAspftsKTPS------- 913
Cdd:cd02086    594 ALPVLPL---VIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVA-----KDASdivltdd 665
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907117575  914 -ISCVPNLIREGRaalmtsfcvfkfmALYSIIQYFSVTLLysiLSNLGDFQFLFIDLA 970
Cdd:cd02086    666 nFASIVNAIEEGR-------------RMFDNIQKFVLHLL---AENVAQVILLLIGLA 707
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
183-896 2.52e-44

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 172.77  E-value: 2.52e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  183 RKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQL-----FSVIL-----WSVDEY---YYYALAIVI-MSVVSIISSL-- 246
Cdd:cd02081      4 RREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILliaaiVSLGLgfytpFGEGEGktgWIEGVAILVaVILVVLVTAGnd 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  247 YSIRKQYVMLHDMVATHstvRVSVCReNEEIEEIFSTDLVPGDVMIIPLnGTVMPCDAVLINGT-CIVNESMLTGESVPV 325
Cdd:cd02081     84 YQKEKQFRKLNSKKEDQ---KVTVIR-DGEVIQISVFDIVVGDIVQLKY-GDLIPADGLLIEGNdLKIDESSLTGESDPI 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  326 TKTnlpnpsvdvkgmgeeqySPETHKRHTLFCGTTVIQTrfyTGelvKAIVVRTGFSTSKGQLVRSILY----PKPTDFK 401
Cdd:cd02081    159 KKT-----------------PDNQIPDPFLLSGTKVLEG---SG---KMLVTAVGVNSQTGKIMTLLRAeneeKTPLQEK 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  402 LYRDA----YLFLLCLVVVAGIGFIYTIINSILNE---------KEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRR 468
Cdd:cd02081    216 LTKLAvqigKVGLIVAALTFIVLIIRFIIDGFVNDgksfsaedlQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKK 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  469 LKK----VgifcispQRINIC---GQLNLVCFDKTGTLTEDgldlwgiqrventrfllpednvcsEMLVKSQFVAcmatc 541
Cdd:cd02081    296 MMKdnnlV-------RHLDACetmGNATAICSDKTGTLTQN------------------------RMTVVQGYIG----- 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  542 hslTKIEGVLSGDPLDLKMfeaigwileeateeetalhnrimptvvrpskqllpepttaGNQEMELFElpaiyEIGIVRQ 621
Cdd:cd02081    340 ---NKTECALLGFVLELGG----------------------------------------DYRYREKRP-----EEKVLKV 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  622 FPFSSALQRMSVVARTL-GEKRMdaYMKGAPEVVASLCK------------PETVPVDFEKVLEDYTKQGFRVIALAHRK 688
Cdd:cd02081    372 YPFNSARKRMSTVVRLKdGGYRL--YVKGASEIVLKKCSyilnsdgevvflTSEKKEEIKRVIEPMASDSLRTIGLAYRD 449
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  689 L-ESKLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKV 767
Cdd:cd02081    450 FsPDEEPTAERDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDG 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  768 IIAEalppkdGKvaKINwhytdslsqcsessaidseaipiKLAHDSLEDLEVTRyhfamngksfsvilehFQDLVPKLMl 847
Cdd:cd02081    530 LVLE------GK--EFR-----------------------ELIDEEVGEVCQEK----------------FDKIWPKLR- 561
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 1907117575  848 hgtVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISL 896
Cdd:cd02081    562 ---VLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAM 607
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
174-895 3.26e-44

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 173.20  E-value: 3.26e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAV-KVPSVFKLLIKEVLNPFyIFQLFSVILWSVDEYYYYA------LAIVIMSVVSIISSL 246
Cdd:cd02077      1 GLTNEEAEERLEKYGPNEISHeKFPSWFKLLLKAFINPF-NIVLLVLALVSFFTDVLLApgefdlVGALIILLMVLISGL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  247 YS----IRKQYV--MLHDMVATHSTVRvsvcRENEEIEEIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCI-VNESMLT 319
Cdd:cd02077     80 LDfiqeIRSLKAaeKLKKMVKNTATVI----RDGSKYMEIPIDELVPGDIVYLS-AGDMIPADVRIIQSKDLfVSQSSLT 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  320 GESVPVTKtnlpnpSVDVKGMGEEQYspeTHKRHTLFCGTTVIqtrfyTGElVKAIVVRTGFSTSKGQLVRSIL-YPKPT 398
Cdd:cd02077    155 GESEPVEK------HATAKKTKDESI---LELENICFMGTNVV-----SGS-ALAVVIATGNDTYFGSIAKSITeKRPET 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  399 DFK--LYRDAYLFLLCLVVVAgigFIYTIINSILNEKEVQEIIIKsldiITITV---PPALPAAMTAGIVYAQRRLKKVG 473
Cdd:cd02077    220 SFDkgINKVSKLLIRFMLVMV---PVVFLINGLTKGDWLEALLFA----LAVAVgltPEMLPMIVTSNLAKGAVRMSKRK 292
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  474 IFCISPQRINICGQLNLVCFDKTGTLTEDgldlwgiqRVENTRFLLPEDNvcsemlvKSQFVACMATCHSL--TKIEgvl 551
Cdd:cd02077    293 VIVKNLNAIQNFGAMDILCTDKTGTLTQD--------KIVLERHLDVNGK-------ESERVLRLAYLNSYfqTGLK--- 354
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  552 sgDPLDLKMFEAIgwileeateeetalHNRIMPTVVRPSKQllpepttagnqemelfelpaIYEIgivrqfPFSSALQRM 631
Cdd:cd02077    355 --NLLDKAIIDHA--------------EEANANGLIQDYTK--------------------IDEI------PFDFERRRM 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  632 SVVARTLGEKRMdAYMKGAPEVVASLC-----KPETVPVD------FEKVLEDYTKQGFRVIALAHRKLESKLTWHKVQH 700
Cdd:cd02077    393 SVVVKDNDGKHL-LITKGAVEEILNVCthvevNGEVVPLTdtlrekILAQVEELNREGLRVLAIAYKKLPAPEGEYSVKD 471
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  701 isrdaiENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGmiLPQDKVIIAealppkdgkv 780
Cdd:cd02077    472 ------EKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVG--LDINRVLTG---------- 533
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  781 akinwhytdslsqcSESSAIDSEAipikLAHdsledlEVTRYhfamngksfsvilehfqdlvpklmlhgTVFARMAPDQK 860
Cdd:cd02077    534 --------------SEIEALSDEE----LAK------IVEET---------------------------NIFAKLSPLQK 562
                          730       740       750
                   ....*....|....*....|....*....|....*
gi 1907117575  861 TQLVEALQNVDYFVGMCGDGANDCGALKRAHGGIS 895
Cdd:cd02077    563 ARIIQALKKNGHVVGFMGDGINDAPALRQADVGIS 597
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
174-982 4.76e-44

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 172.80  E-value: 4.76e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLNPF-YIFQ---LFSVILWSVDEYYYYALAIVIMSVVSIISSLYSi 249
Cdd:cd02076      1 GLTSEEAAKRLKEYGPNELPEKKENPILKFLSFFWGPIpWMLEaaaILAAALGDWVDFAIILLLLLINAGIGFIEERQA- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  250 rkqyvmlHDMVAT--HSTVRVSVCRENEEIEEIFSTDLVPGDVMIIPLnGTVMPCDAVLINGTCI-VNESMLTGESVPVT 326
Cdd:cd02076     80 -------GNAVAAlkKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKI-GDIVPADARLLTGDALqVDQSALTGESLPVT 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  327 KtnlpnpsvdvkgmgeeqyspetHKRHTLFCGTTVIQtrfytGElVKAIVVRTGFSTSKGQLVRSILYPKPTDF--KLYR 404
Cdd:cd02076    152 K----------------------HPGDEAYSGSIVKQ-----GE-MLAVVTATGSNTFFGKTAALVASAEEQGHlqKVLN 203
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  405 DAYLFLLCLVVV-AGIGFIYtiinSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRIN 483
Cdd:cd02076    204 KIGNFLILLALIlVLIIVIV----ALYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIE 279
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  484 ICGQLNLVCFDKTGTLTEDGLDLWGIQRVENTrfllPEDNVCsemlvksqFVACMAtchslTKIEGVlsgDPLDLKMFEA 563
Cdd:cd02076    280 ELAGVDILCSDKTGTLTLNKLSLDEPYSLEGD----GKDELL--------LLAALA-----SDTENP---DAIDTAILNA 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  564 IGwileeateeetalhnriMPTVVRPSKQLLpepttagnqemelfelpaiyeigivrQF-PFSSALQR-MSVVARTLGEK 641
Cdd:cd02076    340 LD-----------------DYKPDLAGYKQL--------------------------KFtPFDPVDKRtEATVEDPDGER 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  642 RmdAYMKGAPEVVASLCK-PETVPVDFEKVLEDYTKQGFRviALAhrkleskltwhkvqhISRDAIENNMDFMGLIIMQN 720
Cdd:cd02076    377 F--KVTKGAPQVILELVGnDEAIRQAVEEKIDELASRGYR--SLG---------------VARKEDGGRWELLGLLPLFD 437
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  721 KLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpQDKVIIAEALPPKDGKVAKinwhytdslsqcsESSAI 800
Cdd:cd02076    438 PPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGM---GTNILSAERLKLGGGGGGM-------------PGSEL 501
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  801 DseaipiklahdslEDLEvtryhfamngksfsvilehfqdlvpklMLHGtvFARMAPDQKTQLVEALQNVDYFVGMCGDG 880
Cdd:cd02076    502 I-------------EFIE---------------------------DADG--FAEVFPEHKYRIVEALQQRGHLVGMTGDG 539
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  881 ANDCGALKRAHGGISLSELE--ASVASPFTSKTPSISCVPNLIREGRAalmtsfcVFKFMALYSIIQyFSVTLLYSILSN 958
Cdd:cd02076    540 VNDAPALKKADVGIAVSGATdaARAAADIVLTAPGLSVIIDAIKTSRQ-------IFQRMKSYVIYR-IAETLRILVFFT 611
                          810       820
                   ....*....|....*....|....
gi 1907117575  959 LGDFQFLFIDLAIILVVVFTMsLN 982
Cdd:cd02076    612 LGILILNFYPLPLIMIVLIAI-LN 634
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
621-974 2.38e-43

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 160.70  E-value: 2.38e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  621 QFPFSSALQRMSVVARTLGEKRMdaYMKGAPEVVASLCKPETVPVD---FEKVLEDYTKQGFRVIALAHRKLESKltwhk 697
Cdd:cd01431     24 EIPFNSTRKRMSVVVRLPGRYRA--IVKGAPETILSRCSHALTEEDrnkIEKAQEESAREGLRVLALAYREFDPE----- 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  698 vqhISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKD 777
Cdd:cd01431     97 ---TSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGIDTKASGVILGEEADEMS 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  778 gkvakinwhytdslsqcsessaidseaipiklahdsledlevtryhfamngksfsvilehfQDLVPKLMLHGTVFARMAP 857
Cdd:cd01431    174 -------------------------------------------------------------EEELLDLIAKVAVFARVTP 192
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  858 DQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSELEASVA---SPFTSKTPSISCVPNLIREGRAALMTSFCV 934
Cdd:cd01431    193 EQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAkeaADIVLLDDNFATIVEAVEEGRAIYDNIKKN 272
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1907117575  935 FKFMALYSIIQYFSVTLLYSI--LSNLGDFQFLFIDLAIILV 974
Cdd:cd01431    273 ITYLLANNVAEVFAIALALFLggPLPLLAFQILWINLVTDLI 314
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
233-904 1.46e-42

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 166.05  E-value: 1.46e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  233 AIVIMSVV---SIISSLYSIRKQYVmLHDMVATHSTvRVSVCRENEEIEEIFSTD-LVPGDVMIIPLnGTVMPCDAVLIN 308
Cdd:cd07539     60 AVLIVGVLtvnAVIGGVQRLRAERA-LAALLAQQQQ-PARVVRAPAGRTQTVPAEsLVPGDVIELRA-GEVVPADARLLE 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  309 GTCI-VNESMLTGESVPVTKTNLPNPSVDVkgmGEeqyspethKRHTLFCGTTViqtrfyTGELVKAIVVRTGFSTSKG- 386
Cdd:cd07539    137 ADDLeVDESALTGESLPVDKQVAPTPGAPL---AD--------RACMLYEGTTV------VSGQGRAVVVATGPHTEAGr 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  387 --QLVRSILYPKPTDFKLYRdayLFLLCLVVVAGIGFIYTIInSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVY 464
Cdd:cd07539    200 aqSLVAPVETATGVQAQLRE---LTSQLLPLSLGGGAAVTGL-GLLRGAPLRQAVADGVSLAVAAVPEGLPLVATLAQLA 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  465 AQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEdgldlwgiqrventrfllpednvcsemlvksqfvacmatchsl 544
Cdd:cd07539    276 AARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTE------------------------------------------- 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  545 tkiegvlsgdpldlkmfeaigwileeateeetalhNRIMPTVVRPskqllpepttagnQEMELfelpaiyeigivrqfPF 624
Cdd:cd07539    313 -----------------------------------NRLRVVQVRP-------------PLAEL---------------PF 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  625 SSALQRMSVVARTLGEKRMDAyMKGAPEVVASLCK-----PETVPVD------FEKVLEDYTKQGFRVIALAHRkleskl 693
Cdd:cd07539    330 ESSRGYAAAIGRTGGGIPLLA-VKGAPEVVLPRCDrrmtgGQVVPLTeadrqaIEEVNELLAGQGLRVLAVAYR------ 402
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  694 TWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilPQDKVIIAEAl 773
Cdd:cd07539    403 TLDAGTTHAVEAVVDDLELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL--PRDAEVVTGA- 479
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  774 ppkdgkvakinwhytdslsqcsESSAIDSEAiPIKLAHDSledlevtryhfamngksfsvilehfqdlvpklmlhgTVFA 853
Cdd:cd07539    480 ----------------------ELDALDEEA-LTGLVADI------------------------------------DVFA 500
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907117575  854 RMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSELEASVA 904
Cdd:cd07539    501 RVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAA 551
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
174-980 3.08e-39

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 159.02  E-value: 3.08e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVP-SVFKLLIKEVLNPFYIFQLFSVIL-WSVDEYYYYALAIVIMSVVSIISSLYSIRK 251
Cdd:TIGR01523   26 GLTHDEAQHRLKEVGENRLEADSGiDAKAMLLHQVCNAMCMVLIIAAAIsFAMHDWIEGGVISAIIALNILIGFIQEYKA 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  252 QYVMlhDMVATHSTVRVSVCReNEEIEEIFSTDLVPGDVMIIPLnGTVMPCDAVLINGTCI-VNESMLTGESVPVTK-TN 329
Cdd:TIGR01523  106 EKTM--DSLKNLASPMAHVIR-NGKSDAIDSHDLVPGDICLLKT-GDTIPADLRLIETKNFdTDEALLTGESLPVIKdAH 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  330 LpnpsvdVKGMGEEqySPETHKRHTLFCGTTVIQTRfytgelVKAIVVRTGFSTSKGQLVRSI-----LYPKPTDF---- 400
Cdd:TIGR01523  182 A------TFGKEED--TPIGDRINLAFSSSAVTKGR------AKGICIATALNSEIGAIAAGLqgdggLFQRPEKDdpnk 247
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  401 ------------KLYRDAYLFLLC-------LVVVAGIGFIYTIINSILNEKEVQEIIIKSLDIITITV-----PPALPA 456
Cdd:TIGR01523  248 rrklnkwilkvtKKVTGAFLGLNVgtplhrkLSKLAVILFCIAIIFAIIVMAAHKFDVDKEVAIYAICLaisiiPESLIA 327
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  457 AMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGL---DLW------------------------GI 509
Cdd:TIGR01523  328 VLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMiarQIWiprfgtisidnsddafnpnegnvsGI 407
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  510 QRVENTRFLLPED-------NVCSEMLVKS--------QFVACMATChSLTKI----------EGVLSGDPLDLKMfeai 564
Cdd:TIGR01523  408 PRFSPYEYSHNEAadqdilkEFKDELKEIDlpedidmdLFIKLLETA-ALANIatvfkddatdCWKAHGDPTEIAI---- 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  565 gwilEEATEEETALHNRIMPtvvrpSKQLLPEPTTAGNQEMELFELPAIYEIGIVRQFPFSSALQRMSVVARTLGEKRMD 644
Cdd:TIGR01523  483 ----HVFAKKFDLPHNALTG-----EEDLLKSNENDQSSLSQHNEKPGSAQFEFIAEFPFDSEIKRMASIYEDNHGETYN 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  645 AYMKGAPEVVASLCK-----------PETVPvDFE---KVLEDYTKQGFRVIALAHRKLESKLTWH---KVQHISRDAIE 707
Cdd:TIGR01523  554 IYAKGAFERIIECCSssngkdgvkisPLEDC-DREliiANMESLAAEGLRVLAFASKSFDKADNNDdqlKNETLNRATAE 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  708 NNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpqdkviiaealppkdgkvakinwhy 787
Cdd:TIGR01523  633 SDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGI--------------------------- 685
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  788 tdslsqcsessaidseaIPIKLAHDSLEDLEvtryHFAMNGKSFSVILEHFQDLVPKLMLhgtVFARMAPDQKTQLVEAL 867
Cdd:TIGR01523  686 -----------------IPPNFIHDRDEIMD----SMVMTGSQFDALSDEEVDDLKALCL---VIARCAPQTKVKMIEAL 741
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  868 QNVDYFVGMCGDGANDCGALKRAHGGISLSELEASV---ASPFTSKTPSISCVPNLIREGRaalmtsfcvfkfmALYSII 944
Cdd:TIGR01523  742 HRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVakdASDIVLSDDNFASILNAIEEGR-------------RMFDNI 808
                          890       900       910
                   ....*....|....*....|....*....|....*....
gi 1907117575  945 QYFSVTLLysiLSNLGDFQFLFIDLAI---ILVVVFTMS 980
Cdd:TIGR01523  809 MKFVLHLL---AENVAEAILLIIGLAFrdeNGKSVFPLS 844
E1-E2_ATPase pfam00122
E1-E2 ATPase;
258-471 1.10e-37

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 139.63  E-value: 1.10e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  258 DMVATHSTVRvsvcrENEEIEEIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCIVNESMLTGESVPVTKtnlpnpsvdv 337
Cdd:pfam00122    1 SLLPPTATVL-----RDGTEEEVPADELVPGDIVLLK-PGERVPADGRIVEGSASVDESLLTGESLPVEK---------- 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  338 kgmgeeqyspetHKRHTLFCGTTVIQtrfytGELvKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVA 417
Cdd:pfam00122   65 ------------KKGDMVYSGTVVVS-----GSA-KAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVV 126
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907117575  418 GIGFIYTIINSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKK 471
Cdd:pfam00122  127 LLIALAVFLLWLFVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAK 180
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
174-904 4.36e-34

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 140.27  E-value: 4.36e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIAVKVPSVFKLLIKEVLN-PFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQ 252
Cdd:cd07538      1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLRePMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQEWRT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  253 YVMLhDMVATHSTVRVSVCRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCI-VNESMLTGESVPVTKTnlp 331
Cdd:cd07538     81 ERAL-EALKNLSSPRATVIRDGRERR-IPSRELVPGDLLILG-EGERIPADGRLLENDDLgVDESTLTGESVPVWKR--- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  332 npsVDvkgmGEEQYSPETHKRHTLFCGTTVIQtrfytGELVkAIVVRTGFSTSKGQLVRSI--LYPKPTDF-----KLYR 404
Cdd:cd07538    155 ---ID----GKAMSAPGGWDKNFCYAGTLVVR-----GRGV-AKVEATGSRTELGKIGKSLaeMDDEPTPLqkqtgRLVK 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  405 daYLFLLCLVVVAGIGFIYtiinsILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINI 484
Cdd:cd07538    222 --LCALAALVFCALIVAVY-----GVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVET 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  485 CGQLNLVCFDKTGTLTEdgldlwgiqrventrfllpednvcsemlvksqfvacmatchsltkiegvlsgdpldlkmfeai 564
Cdd:cd07538    295 LGSITVLCVDKTGTLTK--------------------------------------------------------------- 311
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  565 gwileeateeetalhnrimptvvrpskqllpepttagNQeMELFELpaiyeIGIVRQFPFSSALQRMSVVARTlgEKRMD 644
Cdd:cd07538    312 -------------------------------------NQ-MEVVEL-----TSLVREYPLRPELRMMGQVWKR--PEGAF 346
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  645 AYMKGAPEVVASLCKPETVPVD-FEKVLEDYTKQGFRVIALAHRKLeskltwhKVQHISRDAIENNMDFMGLIIMQNKLK 723
Cdd:cd07538    347 AAAKGSPEAIIRLCRLNPDEKAaIEDAVSEMAGEGLRVLAVAACRI-------DESFLPDDLEDAVFIFVGLIGLADPLR 419
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  724 QETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpqdkviiaealppkdgkvakinwHYTDSLSQCSESSAIDSE 803
Cdd:cd07538    420 EDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-------------------------DNTDNVITGQELDAMSDE 474
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  804 AIPIKLAHDSledlevtryhfamngksfsvilehfqdlvpklmlhgtVFARMAPDQKTQLVEALQNVDYFVGMCGDGAND 883
Cdd:cd07538    475 ELAEKVRDVN-------------------------------------IFARVVPEQKLRIVQAFKANGEIVAMTGDGVND 517
                          730       740
                   ....*....|....*....|.
gi 1907117575  884 CGALKRAHGGISLSELEASVA 904
Cdd:cd07538    518 APALKAAHIGIAMGKRGTDVA 538
P5-ATPase pfam12409
P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically ...
13-146 1.02e-33

P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.


Pssm-ID: 463565  Cd Length: 123  Bit Score: 126.12  E-value: 1.02e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   13 QEDEMEIHGYNLCRWKLAMVFVGVICTGGFLLLLLYWLPEWRVKATCVRAAVKDCEVVLLRttDEFRVWFCAKIHFLPVE 92
Cdd:pfam12409    1 EDLTIEIAGYRTSRWRLALYLLLCVLTLGLLYLLFRWLPRWRVRLTGKPCPLAEADWVVIE--DEFGELSIKKVKKLPYG 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907117575   93 NQpnlnakclVNEVSNgHAVHLTEENRCEMNKYSQSQSQQMRYFTHHSIRYFWN 146
Cdd:pfam12409   79 RP--------LSTVFP-LLVGESSSVISKADEDNDPELPQLRYFDYRYIRYIWH 123
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
183-1024 4.59e-33

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 138.30  E-value: 4.59e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  183 RKLIYGVNEIAVKVPS-VFKLLIKEVLNPFYIFQLFS----VILWSVDEYYYYALAIVIMSVVSIISSlYSIRKQYVMLH 257
Cdd:cd02085      1 RRKLHGPNEFKVEDEEpLWKKYLEQFKNPLILLLLGSavvsVVMKQYDDAVSITVAILIVVTVAFVQE-YRSEKSLEALN 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  258 DMVAThstvRVSVCRENEEiEEIFSTDLVPGDVMIIPLnGTVMPCDAVLINGTCI-VNESMLTGESVPVTKTNLPNPSVD 336
Cdd:cd02085     80 KLVPP----ECHCLRDGKL-EHFLARELVPGDLVCLSI-GDRIPADLRLFEATDLsIDESSLTGETEPCSKTTEVIPKAS 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  337 VKGMgeeqyspeTHKRHTLFCGTTViqtRFYTGelvKAIVVRTGFSTSKGQLVR---SILYPKpTDFKLYRDAYLFLLCL 413
Cdd:cd02085    154 NGDL--------TTRSNIAFMGTLV---RCGHG---KGIVIGTGENSEFGEVFKmmqAEEAPK-TPLQKSMDKLGKQLSL 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  414 VVVAGIGFIYTIinSILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRL-KKVGIFCISPQrINICGQLNLVC 492
Cdd:cd02085    219 YSFIIIGVIMLI--GWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMaKRRAIVKKLPI-VETLGCVNVIC 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  493 FDKTGTLTEDgldlwgiqrventrfllpednvcsEMLVKSQFVACMATCHSLTKieGVLSGDPLDLKMFEaigwileeat 572
Cdd:cd02085    296 SDKTGTLTKN------------------------EMTVTKIVTGCVCNNAVIRN--NTLMGQPTEGALIA---------- 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  573 eeetalhnrimptvvrpskqllpepttagnQEMElFELPAIYEIGI-VRQFPFSSALQRMSV--VARTLGEKRMDAYMKG 649
Cdd:cd02085    340 ------------------------------LAMK-MGLSDIRETYIrKQEIPFSSEQKWMAVkcIPKYNSDNEEIYFMKG 388
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  650 APEVVASLCKPETVPVDFEKVLEDYTKQ------------GFRVIALAHRKLESKLTwhkvqhisrdaiennmdFMGLII 717
Cdd:cd02085    389 ALEQVLDYCTTYNSSDGSALPLTQQQRSeineeekemgskGLRVLALASGPELGDLT-----------------FLGLVG 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  718 MQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALppkdgkvakinwhytdslsqcses 797
Cdd:cd02085    452 INDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEV------------------------ 507
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  798 saidseaipiklahDSLEDLEVTryhfamngksfsvilehfqDLVPKLmlhgTVFARMAPDQKTQLVEALQNVDYFVGMC 877
Cdd:cd02085    508 --------------DQMSDSQLA-------------------SVVRKV----TVFYRASPRHKLKIVKALQKSGAVVAMT 550
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  878 GDGANDCGALKRAHGGISLSELEASV---ASPFTSKTPSISCVPNLIREGRAAL--MTSFCVFKFMALYSIIQYFSVTLL 952
Cdd:cd02085    551 GDGVNDAVALKSADIGIAMGRTGTDVckeAADMILVDDDFSTILAAIEEGKGIFynIKNFVRFQLSTSIAALSLIALSTL 630
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907117575  953 YSILSNLGDFQFLFIDlaIILVVVFTMSL--NPAWKELVAQRPPS---GLISGALLFSVL-SQIVISVGfqSLGFFWV 1024
Cdd:cd02085    631 FNLPNPLNAMQILWIN--IIMDGPPAQSLgvEPVDKDVIRQPPRNvkdPILTRSLILNVLlSAAIIVSG--TLWVFWK 704
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
158-1115 2.28e-30

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 130.28  E-value: 2.28e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  158 LDEGVSCASlYEKHSagltqgmhayRKLIYGVNEIAVKVPSVFKLLIKEVLNPFYIFQL-----FSVILWSVDEYYYYA- 231
Cdd:TIGR01517   56 LNEGVRLSS-STLER----------REKVYGKNELPEKPPKSFLQIVWAALSDQTLILLsvaavVSLVLGLYVPSVGEDk 124
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  232 --------------LAIVIMSVVSIISSlYSIRKQYVMLHDmvaTHSTVRVSVCRENEEIEeIFSTDLVPGDvmIIPLN- 296
Cdd:TIGR01517  125 adtetgwiegvailVSVILVVLVTAVND-YKKELQFRQLNR---EKSAQKIAVIRGGQEQQ-ISIHDIVVGD--IVSLSt 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  297 GTVMPCDAVLING-TCIVNESMLTGESVPVTKtNLPNPSVdvkgmgeeqyspethkrhtLFCGTTVIqtrfyTGElVKAI 375
Cdd:TIGR01517  198 GDVVPADGVFISGlSLEIDESSITGESDPIKK-GPVQDPF-------------------LLSGTVVN-----EGS-GRML 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  376 VVRTGFSTSKGQLVRSILY----PKPTDFKLYRDA-------YLFLLCLVVVAGIGF-IYTIINSILNE------KEVQE 437
Cdd:TIGR01517  252 VTAVGVNSFGGKLMMELRQageeETPLQEKLSELAgligkfgMGSAVLLFLVLSLRYvFRIIRGDGRFEdteedaQTFLD 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  438 IIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCispQRINIC---GQLNLVCFDKTGTLTEDGLDL---WGIQR 511
Cdd:TIGR01517  332 HFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLV---RHLAACetmGSATAICSDKTGTLTQNVMSVvqgYIGEQ 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  512 VENTRFLLPEDNVCSemLVKSQFVACMATCHSLTKI---EGVLS--GDPLDLKMFEaigwileeateeetalhnrimptV 586
Cdd:TIGR01517  409 RFNVRDEIVLRNLPA--AVRNILVEGISLNSSSEEVvdrGGKRAfiGSKTECALLD-----------------------F 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  587 VRPSKQLLPEPttagnqeMELFELPAIYEIgivrqFPFSSALQRMSVVARTLGEKrMDAYMKGAPEVVASLCKP------ 660
Cdd:TIGR01517  464 GLLLLLQSRDV-------QEVRAEEKVVKI-----YPFNSERKFMSVVVKHSGGK-YREFRKGASEIVLKPCRKrldsng 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  661 ETVPVD------FEKVLEDYTKQGFRVIALAHRKLESKltwhkvQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLH 734
Cdd:TIGR01517  531 EATPISeddkdrCADVIEPLASDALRTICLAYRDFAPE------EFPRKDYPNKGLTLIGVVGIKDPLRPGVREAVQECQ 604
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  735 KANIRTVMVTGDNMLTAVSVARDCGmILPQDKViiaealppkdgkvakinwhytdslsqcsessaidseaipiklahdsl 814
Cdd:TIGR01517  605 RAGITVRMVTGDNIDTAKAIARNCG-ILTFGGL----------------------------------------------- 636
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  815 edlevtryhfAMNGKSF-SVILEHFQDLVPKLMlhgtVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGG 893
Cdd:TIGR01517  637 ----------AMEGKEFrSLVYEEMDPILPKLR----VLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVG 702
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  894 ----ISLSELeASVASPFTSKTPSISCVPNLIREGRAalmTSFCVFKFMALYSIIQYFSVTLLY-------SILSNLGDF 962
Cdd:TIGR01517  703 fsmgISGTEV-AKEASDIILLDDNFASIVRAVKWGRN---VYDNIRKFLQFQLTVNVVAVILTFvgscissSHTSPLTAV 778
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  963 QFLFIDLAIILVVVFTMSLNPAWKELVaQRPPSG----LISGALLFSVLSQ------IVISVGFQSLGFFWVK-QYKVCD 1031
Cdd:TIGR01517  779 QLLWVNLIMDTLAALALATEPPTEALL-DRKPIGrnapLISRSMWKNILGQagyqlvVTFILLFAGGSIFDVSgPDEITS 857
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575 1032 PNSDVCNTTRSACWNSSHLYNgtELDSCKIqnYENTTVFfissfqyltvavafskgkpfrQPCYKNYFFVISVIILYVFI 1111
Cdd:TIGR01517  858 HQQGELNTIVFNTFVLLQLFN--EINARKL--YEGMNVF---------------------EGLFKNRIFVTIMGFTFGFQ 912

                   ....
gi 1907117575 1112 LFIM 1115
Cdd:TIGR01517  913 VIIV 916
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
270-1023 1.62e-28

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 124.33  E-value: 1.62e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  270 VCRENEEIEEIFSTDLVPGDVMIIPLnGTVMPCDAVLI---NGTCIVNESMLTGESVPVTKTN--LPNPSVDVKGmgeeq 344
Cdd:cd02083    125 VLRNGKGVQRIRARELVPGDIVEVAV-GDKVPADIRIIeikSTTLRVDQSILTGESVSVIKHTdvVPDPRAVNQD----- 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  345 yspethKRHTLFCGTTVIQTRfytgelVKAIVVRTGFSTSKGQLVRSI---------LYPKPTDFKLYRDAYLFLLCLVV 415
Cdd:cd02083    199 ------KKNMLFSGTNVAAGK------ARGVVVGTGLNTEIGKIRDEMaeteeektpLQQKLDEFGEQLSKVISVICVAV 266
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  416 -VAGIGFIY-------TIINSILNEKevqeiIIKSLDIITItvPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQ 487
Cdd:cd02083    267 wAINIGHFNdpahggsWIKGAIYYFK-----IAVALAVAAI--PEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGC 339
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  488 LNLVCFDKTGTLTEDgldlwgiqrventrfllpEDNVCSEMLVKSQFVACMATCHSLT------KIEGVLSGDPLDLKMF 561
Cdd:cd02083    340 TSVICSDKTGTLTTN------------------QMSVSRMFILDKVEDDSSLNEFEVTgstyapEGEVFKNGKKVKAGQY 401
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  562 EAIGWILEEATE--EETALHNrimptvvrPSKQLLP---EPTTA--------------GNQEMELFELPAIYEIGIVRQF 622
Cdd:cd02083    402 DGLVELATICALcnDSSLDYN--------ESKGVYEkvgEATETaltvlvekmnvfntDKSGLSKRERANACNDVIEQLW 473
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  623 ------PFSSALQRMSVVARTLGEKRMDA-YMKGAPEVVASLC---------KPETVPVDFEKVLED---YTKQGFRVIA 683
Cdd:cd02083    474 kkeftlEFSRDRKSMSVYCSPTKASGGNKlFVKGAPEGVLERCthvrvgggkVVPLTAAIKILILKKvwgYGTDTLRCLA 553
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  684 LAHRKLESKLTWHKVQHISRDA-IENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMIl 762
Cdd:cd02083    554 LATKDTPPKPEDMDLEDSTKFYkYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIF- 632
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  763 pqdkviiaealppkdgkvakinwhytdslsqcsessaidseaipiklahDSLEDLEvtryhfamnGKSFSVilEHFQDLV 842
Cdd:cd02083    633 -------------------------------------------------GEDEDTT---------GKSYTG--REFDDLS 652
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  843 P----KLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISL-SELE-ASVASPFTSKTPSISC 916
Cdd:cd02083    653 PeeqrEACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMgSGTAvAKSASDMVLADDNFAT 732
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  917 VPNLIREGRaalmtsfcvfkfmALYSIIQYFsvtLLYSILSNLGDFQFLFIDLAIIL-----------VVVFT------- 978
Cdd:cd02083    733 IVAAVEEGR-------------AIYNNMKQF---IRYLISSNIGEVVSIFLTAALGLpealipvqllwVNLVTdglpata 796
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1907117575  979 MSLNPAWKELVAQRPPS---GLISGALLFSVLSqIVISVGFQSLG-FFW 1023
Cdd:cd02083    797 LGFNPPDLDIMKKPPRKpdePLISGWLFFRYLA-IGTYVGLATVGaFAW 844
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
234-1008 1.74e-27

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 119.69  E-value: 1.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  234 IVIMSVVSIISSLYSiRKQYVMLHDMVATHSTVRvsvcRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCI- 312
Cdd:cd02609     65 IIVNTVIGIVQEIRA-KRQLDKLSILNAPKVTVI----RDGQEVK-IPPEELVLDDILILK-PGEQIPADGEVVEGGGLe 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  313 VNESMLTGESVPVTKTnlpnpsvdvkgMGEEQYSpethkrhtlfcGTTVIqtrfyTGElVKAIVVRTGFSTSKGQLVRSI 392
Cdd:cd02609    138 VDESLLTGESDLIPKK-----------AGDKLLS-----------GSFVV-----SGA-AYARVTAVGAESYAAKLTLEA 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  393 LYPKPTDFKLYRDAYL---FLLCLVVVAGIGFIYTIInsILNEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRL 469
Cdd:cd02609    190 KKHKLINSELLNSINKilkFTSFIIIPLGLLLFVEAL--FRRGGGWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRL 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  470 KKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLdlwgiqRVENTrFLLPEDNVCSEMLVKSQFVACMAtchsltkieg 549
Cdd:cd02609    268 AKKKVLVQELYSIETLARVDVLCLDKTGTITEGKM------KVERV-EPLDEANEAEAAAALAAFVAASE---------- 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  550 vlsgDPldlkmfeaigwileeateeetalhNRIMptvvrpskQLLPEPTTAGNQemelfelpaiyeIGIVRQFPFSSALQ 629
Cdd:cd02609    331 ----DN------------------------NATM--------QAIRAAFFGNNR------------FEVTSIIPFSSARK 362
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  630 RMSVVARTLGekrmdAYMKGAPEVVASlckpeTVPVDFEKVLEDYTKQGFRVIALAhrKLESKLTWHKVQhisrDAIENn 709
Cdd:cd02609    363 WSAVEFRDGG-----TWVLGAPEVLLG-----DLPSEVLSRVNELAAQGYRVLLLA--RSAGALTHEQLP----VGLEP- 425
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  710 mdfMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGmilpqdkviiaealppkdgkvakinwhytd 789
Cdd:cd02609    426 ---LALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG------------------------------ 472
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  790 slsqcsessaIDSEAIPIKLAHDSLEdlevtryhfamngksfsvilEHFQDLVPKLmlhgTVFARMAPDQKTQLVEALQN 869
Cdd:cd02609    473 ----------LEGAESYIDASTLTTD--------------------EELAEAVENY----TVFGRVTPEQKRQLVQALQA 518
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  870 VDYFVGMCGDGANDCGALKRAHGGISLSEleasvASPFTSKTPSI-------SCVPNLIREGR---AALMTSFCVFKFMA 939
Cdd:cd02609    519 LGHTVAMTGDGVNDVLALKEADCSIAMAS-----GSDATRQVAQVvlldsdfSALPDVVFEGRrvvNNIERVASLFLVKT 593
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907117575  940 LYSIIqyfsVTLLYSILSnlgdFQFLFIDLAIILVVVFTMSLnPAWkeLVAQRPPSGLISGALLFSVLS 1008
Cdd:cd02609    594 IYSVL----LALICVITA----LPFPFLPIQITLISLFTIGI-PSF--FLALEPNKRRIEGGFLRRVLT 651
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
617-977 4.16e-26

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 116.16  E-value: 4.16e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  617 GIVRQFPFSSALQRMSVVARTLGEKRMDAYMKGAPEVVASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLESK--LT 694
Cdd:cd07536    392 CILQLLEFTSDRKRMSVIVRDESTGEITLYMKGADVAISPIVSKDSYMEQYNDWLEEECGEGLRTLCVAKKALTENeyQE 471
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  695 WHKV------------QHISR--DAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGM 760
Cdd:cd07536    472 WESRyteaslslhdrsLRVAEvvESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHL 551
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  761 ILPQDKVIIAEaLPPKDGKVAKINWHYTDSLSQCSESsaidseaipiklaHDSLedlevtryhFAMNGKSFSVILEH--- 837
Cdd:cd07536    552 VSRTQDIHLLR-QDTSRGERAAITQHAHLELNAFRRK-------------HDVA---------LVIDGDSLEVALKYyrh 608
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  838 -FQDLVpkLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMC-GDGANDCGALKRAHGGISLS---ELEASVASPFT---- 908
Cdd:cd07536    609 eFVELA--CQCPAVICCRVSPTQKARIVTLLKQHTGRRTLAiGDGGNDVSMIQAADCGVGISgkeGKQASLAADYSitqf 686
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907117575  909 SKTPSISCVPNLIREGRAALMTSFCVFKFMALYSI------IQYFSVTLLYSILSnLGDFQFLFIDLAIILVVVF 977
Cdd:cd07536    687 RHLGRLLLVHGRNSYNRSAALGQYVFYKGLIISTIqavfsfVFGFSGVPLFQGFL-MVGYNVIYTMFPVFSLVID 760
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
212-907 4.25e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 106.49  E-value: 4.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  212 YIFQLFSVIL-----WSVDEYYYYALAIVIMSVVSIISSLYSIRKQYVMlhDMVATHSTVRVSvcrENEEIEEIFSTDLV 286
Cdd:cd02073     28 NLYFLFIAILqqipgISPTGPYTTLLPLLFVLGVTAIKEGYEDIRRHKS--DNEVNNRPVQVL---RGGKFVKKKWKDIR 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  287 PGDVMIIPLNGTVmPCDAVLI-----NGTCIVNESMLTGES-------VPVTKT----------------NLPNPSVD-- 336
Cdd:cd02073    103 VGDIVRVKNDEFV-PADLLLLsssepDGLCYVETANLDGETnlkirqaLPETALllseedlarfsgeiecEQPNNDLYtf 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  337 -----VKGMGEEQYSPEthkrHTLFCGTTVIQTRFYTGelvkaIVVRTGFSTsKGQLVRSILYPKPT--DFKLYRDAY-- 407
Cdd:cd02073    182 ngtleLNGGRELPLSPD----NLLLRGCTLRNTEWVYG-----VVVYTGHET-KLMLNSGGTPLKRSsiEKKMNRFIIai 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  408 -LFLLCLVVVAGIG------------FIYTIINSILNEKEVQEIIIKSLDIITITVPPALpaAMTAGIVyaqrrlKKVGI 474
Cdd:cd02073    252 fCILIVMCLISAIGkgiwlskhgrdlWYLLPKEERSPALEFFFDFLTFIILYNNLIPISL--YVTIEVV------KFLQS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  475 FCIS---------------PQRINI---CGQLNLVCFDKTGTLTEdgldlwgiqrventrfllpedNV-----CSEMLVK 531
Cdd:cd02073    324 FFINwdldmydeetdtpaeARTSNLneeLGQVEYIFSDKTGTLTE---------------------NImefkkCSINGVD 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  532 SQFVACMATCHSLtkiegVLSGDPLDLKM-FEAIGwileeateeetalhnrimptvvrPSKQLLPEP--------TTAGN 602
Cdd:cd02073    383 YGFFLALALCHTV-----VPEKDDHPGQLvYQASS-----------------------PDEAALVEAardlgfvfLSRTP 434
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  603 QEMELFELPAIYEIGIVRQFPFSSALQRMSVVART-LGEKRMdaYMKGAPEVVASLCKPETVPV--DFEKVLEDYTKQGF 679
Cdd:cd02073    435 DTVTINALGEEEEYEILHILEFNSDRKRMSVIVRDpDGRILL--YCKGADSVIFERLSPSSLELveKTQEHLEDFASEGL 512
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  680 RVIALAHRKLESK--LTWHKVQHISRDA--------------IENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMV 743
Cdd:cd02073    513 RTLCLAYREISEEeyEEWNEKYDEASTAlqnreelldevaeeIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVL 592
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  744 TGDNMLTAVSVARDCGMILPQDK---VIIaealppkDGKvakinwhytdSLSqcsessaidseaipiklahdsledlevt 820
Cdd:cd02073    593 TGDKQETAINIGYSCRLLSEDMEnlaLVI-------DGK----------TLT---------------------------- 627
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  821 ryhFAMNGKSFSVilehFQDLVpkLMLHGTVFARMAPDQKTQLVEALQN-VDYFVGMCGDGANDCGALKRAHGGISLSEL 899
Cdd:cd02073    628 ---YALDPELERL----FLELA--LKCKAVICCRVSPLQKALVVKLVKKsKKAVTLAIGDGANDVSMIQEAHVGVGISGQ 698
                          810
                   ....*....|.
gi 1907117575  900 E---ASVASPF 907
Cdd:cd02073    699 EgmqAARASDY 709
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
171-895 1.15e-22

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 105.11  E-value: 1.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  171 HSAGLTQGMHAYRKLIYGVNEIA-VKVPSVFKLLIKEVLNPF-YIFQLFSVILWSVDeyYYYAL----------AIVIMS 238
Cdd:PRK15122    42 HRQGLTEEDAAERLQRYGPNEVAhEKPPHALVQLLQAFNNPFiYVLMVLAAISFFTD--YWLPLrrgeetdltgVIIILT 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  239 VVSIiSSL------YSIRKQYVMLHDMVATHSTV--RVSVCREnEEIEEIFSTDLVPGDvmIIPLN-GTVMPCDAVLING 309
Cdd:PRK15122   120 MVLL-SGLlrfwqeFRSNKAAEALKAMVRTTATVlrRGHAGAE-PVRREIPMRELVPGD--IVHLSaGDMIPADVRLIES 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  310 -TCIVNESMLTGESVPVTKtnlpnpsVDVKGMGEEQYSPETHK--------RHTLFCGTTVIQTRfytgelVKAIVVRTG 380
Cdd:PRK15122   196 rDLFISQAVLTGEALPVEK-------YDTLGAVAGKSADALADdegslldlPNICFMGTNVVSGT------ATAVVVATG 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  381 FSTSKGQLVRSILYPKP-TDFK---------LYRdaylFLLCLVVVAgigfiyTIINSiLNEKEVQEIIIKSLDIITITV 450
Cdd:PRK15122   263 SRTYFGSLAKSIVGTRAqTAFDrgvnsvswlLIR----FMLVMVPVV------LLING-FTKGDWLEALLFALAVAVGLT 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  451 PPALPAAMTA----GIVYAQRRlkKVGIfcispQRINIC---GQLNLVCFDKTGTLTEDgldlwgiqrventRFLLPedn 523
Cdd:PRK15122   332 PEMLPMIVSSnlakGAIAMARR--KVVV-----KRLNAIqnfGAMDVLCTDKTGTLTQD-------------RIILE--- 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  524 vcsemlvksqfvacmatcHSLtKIEGVLSGDPLDLkmfeaiGWIleeateeeTALHNRIMptvvrpsKQLLPEPTTAGNQ 603
Cdd:PRK15122   389 ------------------HHL-DVSGRKDERVLQL------AWL--------NSFHQSGM-------KNLMDQAVVAFAE 428
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  604 EMELFELPAIYeiGIVRQFPFSSALQRMSV-VARTLGEKRMdaYMKGAPEVVASLCK-----PETVPVDF---EKVL--- 671
Cdd:PRK15122   429 GNPEIVKPAGY--RKVDELPFDFVRRRLSVvVEDAQGQHLL--ICKGAVEEMLAVAThvrdgDTVRPLDEarrERLLala 504
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  672 EDYTKQGFRVIALAHRKLESkltwHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTA 751
Cdd:PRK15122   505 EAYNADGFRVLLVATREIPG----GESRAQYSTADERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVT 580
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  752 VSVARDCGMilpqdkviiaEALPPKDGKvakinwhytdslsqcsessaiDSEAipiklahdsLEDLEVTRyhfamngksf 831
Cdd:PRK15122   581 AKICREVGL----------EPGEPLLGT---------------------EIEA---------MDDAALAR---------- 610
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907117575  832 svilehfqdlvpkLMLHGTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGIS 895
Cdd:PRK15122   611 -------------EVEERTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGIS 661
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
133-895 3.81e-22

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 103.61  E-value: 3.81e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  133 MRYFTHHSIRYFWNDAIHNFDFLKG------LDEGVSCAS------LYEK---HSAGLTQGMHAYRKLIYGVNEIAVKVP 197
Cdd:PRK10517    11 TRLLRHLPSRLVHRDPLPGAQQTVNtavppsLSARCLKAAvmpeeeLWKTfdtHPEGLNEAEVESAREQHGENELPAQKP 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  198 SVFKL-LIKEVLNPFYIF-QLFSVILWSVDEYYyyaLAIVIMSVVsIISSLYSI------RKQYVMLHDMVATHSTV-RV 268
Cdd:PRK10517    91 LPWWVhLWVCYRNPFNILlTILGAISYATEDLF---AAGVIALMV-AISTLLNFiqearsTKAADALKAMVSNTATVlRV 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  269 SVCRENEEIEEIFSTDLVPGDvmIIPLN-GTVMPCDA-VLINGTCIVNESMLTGESVPVTKTNLPNPSvdvkgmgeEQYS 346
Cdd:PRK10517   167 INDKGENGWLEIPIDQLVPGD--IIKLAaGDMIPADLrILQARDLFVAQASLTGESLPVEKFATTRQP--------EHSN 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  347 P-ETHkrHTLFCGTTVIqtrfyTGElVKAIVVRTGFSTSKGQLVRSILYP--KPTDFK--LYRDAYLFLLCLVVVAGIGF 421
Cdd:PRK10517   237 PlECD--TLCFMGTNVV-----SGT-AQAVVIATGANTWFGQLAGRVSEQdsEPNAFQqgISRVSWLLIRFMLVMAPVVL 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  422 iytIINSiLNEKEVQEIIIKSLDIITITVPPALPAAMTA----GIVYAQRrlKKVGIfcispQR---INICGQLNLVCFD 494
Cdd:PRK10517   309 ---LING-YTKGDWWEAALFALSVAVGLTPEMLPMIVTStlarGAVKLSK--QKVIV-----KRldaIQNFGAMDILCTD 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  495 KTGTLTEDGL------DLWGiqrventrfllpednvcsemlVKSQFVACMATCHSLTKI-------EGVLSGDPLDLKMF 561
Cdd:PRK10517   378 KTGTLTQDKIvlenhtDISG---------------------KTSERVLHSAWLNSHYQTglknlldTAVLEGVDEESARS 436
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  562 EAIGWileeateeetalhnrimptvvrpskqllpepttagnqemelfelPAIYEIgivrqfPFSSALQRMSVVARTLGEK 641
Cdd:PRK10517   437 LASRW--------------------------------------------QKIDEI------PFDFERRRMSVVVAENTEH 466
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  642 RmDAYMKGAPEVVASLCK-----PETVPVD------FEKVLEDYTKQGFRVIALAHRKLESKLTWHKVqhisrdAIENNM 710
Cdd:PRK10517   467 H-QLICKGALEEILNVCSqvrhnGEIVPLDdimlrrIKRVTDTLNRQGLRVVAVATKYLPAREGDYQR------ADESDL 539
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  711 DFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGmiLPQDKVIIAealppkdgkvakinwhytds 790
Cdd:PRK10517   540 ILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVG--LDAGEVLIG-------------------- 597
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  791 lsqcsessaidseaipiklahdslEDLEvtryhfAMNGKSFSVILEHFqdlvpklmlhgTVFARMAPDQKTQLVEALQNV 870
Cdd:PRK10517   598 ------------------------SDIE------TLSDDELANLAERT-----------TLFARLTPMHKERIVTLLKRE 636
                          810       820
                   ....*....|....*....|....*
gi 1907117575  871 DYFVGMCGDGANDCGALKRAHGGIS 895
Cdd:PRK10517   637 GHVVGFMGDGINDAPALRAADIGIS 661
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
190-953 5.30e-22

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 103.23  E-value: 5.30e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  190 NEIAVKVPSVFKLLIKEVLNPF----YIFQLFSVILWSVDEY--YYYALAIVIMSVVSIISSL------YSIRKQyvmlh 257
Cdd:TIGR01652    4 NKISTTKYTVLTFLPKNLFEQFkrfaNLYFLVVALLQQVPILspTYRGTSIVPLAFVLIVTAIkeaiedIRRRRR----- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  258 DMVATHSTVrvSVCRENEEIEEIFSTDLVPGDVMIIpLNGTVMPCDAVLI-----NGTCIVNESMLTGE-------SVPV 325
Cdd:TIGR01652   79 DKEVNNRLT--EVLEGHGQFVEIPWKDLRVGDIVKV-KKDERIPADLLLLsssepDGVCYVETANLDGEtnlklrqALEE 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  326 TKTNL----------------PNPS-------VDVKGMGEEQYSPEthkrHTLFCGTTVIQTRF------YTGELVKAIV 376
Cdd:TIGR01652  156 TQKMLdeddiknfsgeieceqPNASlysfqgnMTINGDRQYPLSPD----NILLRGCTLRNTDWvigvvvYTGHDTKLMR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  377 VRTGFSTSKGQLVRSILYPKPTDFklyrdAYLFLLCLVVVAGIGFIYTIINSILN--EKEVQEIIIKSLDIITIT----- 449
Cdd:TIGR01652  232 NATQAPSKRSRLEKELNFLIIILF-----CLLFVLCLISSVGAGIWNDAHGKDLWyiRLDVSERNAAANGFFSFLtflil 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  450 ----VPPALPAAM-TAGIVYAQRRLKKVGIFCI------SPQRINI---CGQLNLVCFDKTGTLTEDGLDLW--GIQRVE 513
Cdd:TIGR01652  307 fsslIPISLYVSLeLVKSVQAYFINSDLQMYHEktdtpaSVRTSNLneeLGQVEYIFSDKTGTLTQNIMEFKkcSIAGVS 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  514 NTRFLlPEDNVCS------------EMLVKSQ-------------------------FVACMATCHSLTKIegvLSGDPL 556
Cdd:TIGR01652  387 YGDGF-TEIKDGIrerlgsyvenenSMLVESKgftfvdprlvdllktnkpnakrineFFLALALCHTVVPE---FNDDGP 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  557 DLKMFEAI----GWILEEATEEETALHNRimptvvRPSKQLLPEPTTAGNQEMELFELpaiyeigivrqFPFSSALQRMS 632
Cdd:TIGR01652  463 EEITYQAAspdeAALVKAARDVGFVFFER------TPKSISLLIEMHGETKEYEILNV-----------LEFNSDRKRMS 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  633 VVARtLGEKRMDAYMKGAPEVVASLCKPETVPVDFE--KVLEDYTKQGFRVIALAHRKLESK--LTWHKVQHISR----- 703
Cdd:TIGR01652  526 VIVR-NPDGRIKLLCKGADTVIFKRLSSGGNQVNEEtkEHLENYASEGLRTLCIAYRELSEEeyEEWNEEYNEAStaltd 604
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  704 ---------DAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVII--AEA 772
Cdd:TIGR01652  605 reekldvvaESIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVitSDS 684
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  773 LPPKDGKVAKINWHYTDSLSQCSESSAIDSEAIPIklahdsledlevtryhfamNGKSFSVILEH-----FQDLVpkLML 847
Cdd:TIGR01652  685 LDATRSVEAAIKFGLEGTSEEFNNLGDSGNVALVI-------------------DGKSLGYALDEelekeFLQLA--LKC 743
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  848 HGTVFARMAPDQKTQLVEALQNVDYFVGMC-GDGANDCGALKRAHGGISLSELE---ASVASPFTSKTPSIsCVPNLIRE 923
Cdd:TIGR01652  744 KAVICCRVSPSQKADVVRLVKKSTGKTTLAiGDGANDVSMIQEADVGVGISGKEgmqAVMASDFAIGQFRF-LTKLLLVH 822
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|.
gi 1907117575  924 G-----RAALMTSFCVFKFMAL------YSIIQYFSVTLLY 953
Cdd:TIGR01652  823 GrwsykRISKMILYFFYKNLIFaiiqfwYSFYNGFSGQTLY 863
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
265-898 1.15e-20

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 98.29  E-value: 1.15e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  265 TVRVsvcRENEEIEEIFSTDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTnlpnpsvdvKGmgeeq 344
Cdd:COG2217    214 TARV---LRDGEEVEVPVEELRVGDRVLV-RPGERIPVDGVVLEGESSVDESMLTGESLPVEKT---------PG----- 275
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  345 yspethkrHTLFCGTTVIQTRFytgeLVKaiVVRTGFSTSKGQLVRSI---LYPKP-----TDfklyRDAYLFLLCLVVV 416
Cdd:COG2217    276 --------DEVFAGTINLDGSL----RVR--VTKVGSDTTLARIIRLVeeaQSSKApiqrlAD----RIARYFVPAVLAI 337
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  417 AGIGFIYTIINSilneKEVQEIIIKSLDIITITVPPAL----PAAMTAGIvyaqRRLKKVGIFCISPQRINICGQLNLVC 492
Cdd:COG2217    338 AALTFLVWLLFG----GDFSTALYRAVAVLVIACPCALglatPTAIMVGT----GRAARRGILIKGGEALERLAKVDTVV 409
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  493 FDKTGTLTEdgldlwGIQRVENTRFLLPEDNvcSEMLvksQFVACMATC--HSLTKiegvlsgdpldlkmfeAIgwilee 570
Cdd:COG2217    410 FDKTGTLTE------GKPEVTDVVPLDGLDE--DELL---ALAAALEQGseHPLAR----------------AI------ 456
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  571 ateeetalhnrimptvVRpskqllpeptTAGNQEMELFElpaiyeigiVRQFpfsSALQRMSVVARTLGEKrmdaYMKGA 650
Cdd:COG2217    457 ----------------VA----------AAKERGLELPE---------VEDF---EAIPGKGVEATVDGKR----VLVGS 494
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 PEVVASLckPETVPVDFEKVLEDYTKQGFRVIALahrkleskltwhkvqhisrdAIENNmdFMGLIIMQNKLKQETPAVL 730
Cdd:COG2217    495 PRLLEEE--GIDLPEALEERAEELEAEGKTVVYV--------------------AVDGR--LLGLIALADTLRPEAAEAI 550
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  731 EDLHKANIRTVMVTGDNMLTAVSVARDCGmilpqdkviiaealppkdgkvakinwhytdslsqcsessaIDseaipikla 810
Cdd:COG2217    551 AALKALGIRVVMLTGDNERTAEAVARELG----------------------------------------ID--------- 581
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  811 hdsledlevtryhfamngksfsvilehfqdlvpklmlhgTVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRA 890
Cdd:COG2217    582 ---------------------------------------EVRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAA 622

                   ....*...
gi 1907117575  891 HGGISLSE 898
Cdd:COG2217    623 DVGIAMGS 630
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
267-928 8.57e-20

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 95.01  E-value: 8.57e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  267 RVSVCRENEEIEEIFSTDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTnlpnpsvdvkgmgeeqys 346
Cdd:TIGR01525   56 TARVLQGDGSEEEVPVEELQVGDIVIV-RPGERIPVDGVVISGESEVDESALTGESMPVEKK------------------ 116
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  347 pethKRHTLFCGTTVIQTRFYtgelVKaiVVRTGFSTSKGQLVRSI----LYPKPTDFKLYRDAYLFLLCLVVVAGIGFI 422
Cdd:TIGR01525  117 ----EGDEVFAGTINGDGSLT----IR--VTKLGEDSTLAQIVELVeeaqSSKAPIQRLADRIASYYVPAVLAIALLTFV 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  423 YTIINSILNekevQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEd 502
Cdd:TIGR01525  187 VWLALGALW----REALYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTT- 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  503 gldlwGIQRVENTRFLlpEDNVCSEMLvksQFVACMAtchsltkiegVLSGDPLdlkmfeAIGwileeateeetalhnri 582
Cdd:TIGR01525  262 -----GKPTVVDIEPL--DDASEEELL---ALAAALE----------QSSSHPL------ARA----------------- 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  583 mptVVRPSKQLLPEPTTagnqemELFElpaiYEIGivrqfpfssalqrMSVVARTLGEKRmdaYMKGAPEVVASLCKPET 662
Cdd:TIGR01525  299 ---IVRYAKERGLELPP------EDVE----EVPG-------------KGVEATVDGGRE---VRIGNPRFLGNRELAIE 349
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  663 VPVDFEKVLEDYTKQGFRVIALAhrkLESKLTwhkvqhisrdaiennmdfmGLIIMQNKLKQETPAVLEDLHKAN-IRTV 741
Cdd:TIGR01525  350 PISASPDLLNEGESQGKTVVFVA---VDGELL-------------------GVIALRDQLRPEAKEAIAALKRAGgIKLV 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  742 MVTGDNMLTAVSVARDCGmilpqdkviiaealppkdgkvakinwhytdslsqcsessaIDSEaipiklahdsledlevtr 821
Cdd:TIGR01525  408 MLTGDNRSAAEAVAAELG----------------------------------------IDDE------------------ 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  822 yhfamngksfsvilehfqdlvpklmlhgtVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISL---SE 898
Cdd:TIGR01525  430 -----------------------------VHAELLPEDKLAIVKKLQEEGGPVAMVGDGINDAPALAAADVGIAMgsgSD 480
                          650       660       670
                   ....*....|....*....|....*....|
gi 1907117575  899 LeASVASPFTSKTPSISCVPNLIREGRAAL 928
Cdd:TIGR01525  481 V-AIEAADIVLLNDDLRSLPTAIDLSRKTR 509
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
267-781 1.49e-19

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 94.24  E-value: 1.49e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  267 RVSVCRENEEIEEIFSTDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTnlpnpsvdvKGmgeeqys 346
Cdd:cd07551    113 TARRIQRDGEIEEVPVEELQIGDRVQV-RPGERVPADGVILSGSSSIDEASITGESIPVEKT---------PG------- 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  347 pethkrHTLFCGT-------TVIQTRFYTGELVKAIVvrtgfstskgQLVRSILYPK-PTDFKLYR--DAYLFLLCLVVV 416
Cdd:cd07551    176 ------DEVFAGTingsgalTVRVTKLSSDTVFAKIV----------QLVEEAQSEKsPTQSFIERfeRIYVKGVLLAVL 239
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  417 AGIgfiytIINSILNEKEVQEIIIKSLDIITITVPPAL----PAAMTAGIVYAQRR--LKKVGIFcispqrINICGQLNL 490
Cdd:cd07551    240 LLL-----LLPPFLLGWTWADSFYRAMVFLVVASPCALvastPPATLSAIANAARQgvLFKGGVH------LENLGSVKA 308
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  491 VCFDKTGTLTEdgldlwGIQRVENTRFLLPEDNvcSEMLvksQFVACMATchsltkiegvLSGDPLDlkmfEAIgwilee 570
Cdd:cd07551    309 IAFDKTGTLTE------GKPRVTDVIPAEGVDE--EELL---QVAAAAES----------QSEHPLA----QAI------ 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  571 ateeetalhnrimptVVRPSKQLLPEPTTAGNQEMELFELPAIYEIGIVRqfpfssalqrmsvvartLGekrmdaymkga 650
Cdd:cd07551    358 ---------------VRYAEERGIPRLPAIEVEAVTGKGVTATVDGQTYR-----------------IG----------- 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 pevvaslcKPETvpvdFEKVLEDYTKQgfrviALAHRKLESKLTwhkVQHISRDAIennmdFMGLIIMQNKLKQETPAVL 730
Cdd:cd07551    395 --------KPGF----FGEVGIPSEAA-----ALAAELESEGKT---VVYVARDDQ-----VVGLIALMDTPRPEAKEAI 449
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907117575  731 EDLHKANIRTVMVTGDNMLTAVSVARDCGM------ILPQDKVIIAEALPPKDGKVA 781
Cdd:cd07551    450 AALRLGGIKTIMLTGDNERTAEAVAKELGIdevvanLLPEDKVAIIRELQQEYGTVA 506
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
213-896 2.36e-19

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 94.47  E-value: 2.36e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  213 IFQLFSVILW--------------------SVDEYYyyaLAIVIMSVVsIISSLYSIRKQY----VM--LHDMVATHSTV 266
Cdd:TIGR01106   70 LFGGFSMLLWigailcflaygiqasteeepQNDNLY---LGVVLSAVV-IITGCFSYYQEAksskIMesFKNMVPQQALV 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  267 rvsvCRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLINGT-CIVNESMLTGESVPVTKtnlpnpsvdvkgmgeeqy 345
Cdd:TIGR01106  146 ----IRDGEKMS-INAEQVVVGDLVEVK-GGDRIPADLRIISAQgCKVDNSSLTGESEPQTR------------------ 201
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  346 SPE-THK-----RHTLFCGTTVIQTrfytgeLVKAIVVRTGFSTSKGQL--VRSILYPKPTDFKLYRDAYLFLLCLVVVA 417
Cdd:TIGR01106  202 SPEfTHEnpletRNIAFFSTNCVEG------TARGIVVNTGDRTVMGRIasLASGLENGKTPIAIEIEHFIHIITGVAVF 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  418 gIGFIYTIINSILnEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTG 497
Cdd:TIGR01106  276 -LGVSFFILSLIL-GYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTG 353
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  498 TLTEDGLD---LW---GIQRVENTrfllpEDNvcsemlVKSQFVACMATCHSLTKIEGVLsgdpldlkmfeaigwileea 571
Cdd:TIGR01106  354 TLTQNRMTvahMWfdnQIHEADTT-----EDQ------SGVSFDKSSATWLALSRIAGLC-------------------- 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  572 teeetalhNRimpTVVRPSKQLLPEP--TTAGNQE----MELFEL------------PAIYEIgivrqfPFSSALQ-RMS 632
Cdd:TIGR01106  403 --------NR---AVFKAGQENVPILkrAVAGDASesalLKCIELclgsvmemrernPKVVEI------PFNSTNKyQLS 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  633 VVAR-TLGEKRMDAYMKGAPEVVASLC-----KPETVPVDfEKVLEDYTKQ-------GFRVIALAHRKLESKlTWHKVQ 699
Cdd:TIGR01106  466 IHENeDPRDPRHLLVMKGAPERILERCssiliHGKEQPLD-EELKEAFQNAylelgglGERVLGFCHLYLPDE-QFPEGF 543
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  700 HISRDAIE---NNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVI--IA---- 770
Cdd:TIGR01106  544 QFDTDDVNfptDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVedIAarln 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  771 ---EALPPKDGKVAKINwhytdslsqCSESSAIDSEAIPiklahdsledlEVTRYHFAMngksfsvilehfqdlvpklml 847
Cdd:TIGR01106  624 ipvSQVNPRDAKACVVH---------GSDLKDMTSEQLD-----------EILKYHTEI--------------------- 662
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 1907117575  848 hgtVFARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISL 896
Cdd:TIGR01106  663 ---VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 708
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
272-817 5.41e-19

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 92.66  E-value: 5.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  272 RENEEIEEIFSTDLVPGDVMIIPLNGTVmPCDAVLINGTCIVNESMLTGESVPVTktnlpnpsvdvKGMGEEQYSpethk 351
Cdd:cd02079    130 LEDGSTEEVPVDDLKVGDVVLVKPGERI-PVDGVVVSGESSVDESSLTGESLPVE-----------KGAGDTVFA----- 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  352 rhtlfcGTTViqtrfYTGEL-VKaiVVRTGFSTSKGQ---LVRSILYPKPtdfKLYRDA-----YLFLLCLVVVAGIGFI 422
Cdd:cd02079    193 ------GTIN-----LNGPLtIE--VTKTGEDTTLAKiirLVEEAQSSKP---PLQRLAdrfarYFTPAVLVLAALVFLF 256
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  423 YTIINSILNEKevqeiIIKSLDIITITVPPAL----PAAMTAGIvyaqRRLKKVGIFCISPQRINICGQLNLVCFDKTGT 498
Cdd:cd02079    257 WPLVGGPPSLA-----LYRALAVLVVACPCALglatPTAIVAGI----GRAARKGILIKGGDVLETLAKVDTVAFDKTGT 327
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  499 LTEDgldlwgiqRVENTRFLLPEDNVCSEMLvksQFVACMA--TCHSLTKiegvlsgdpldlkmfeaigwileeateeet 576
Cdd:cd02079    328 LTEG--------KPEVTEIEPLEGFSEDELL---ALAAALEqhSEHPLAR------------------------------ 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  577 alhnrimpTVVRPSKQLLPEPTTAGNQEmelfELPAiyeIGIvrqfpfssalqrmsvVARTLGEKrmdaYMKGAPEVVAS 656
Cdd:cd02079    367 --------AIVEAAEEKGLPPLEVEDVE----EIPG---KGI---------------SGEVDGRE----VLIGSLSFAEE 412
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  657 LCKPETVpvdfeKVLEDYTKQGFRVIALAHRKLeskltwhkvqhisrdaiennmdfmGLIIMQNKLKQETPAVLEDLHKA 736
Cdd:cd02079    413 EGLVEAA-----DALSDAGKTSAVYVGRDGKLV------------------------GLFALEDQLRPEAKEVIAELKSG 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  737 NIRTVMVTGDNMLTAVSVARDCGM------ILPQDKVIIAEALPPKDGKVA----KINwhytDS--LSQCS------ESS 798
Cdd:cd02079    464 GIKVVMLTGDNEAAAQAVAKELGIdevhagLLPEDKLAIVKALQAEGGPVAmvgdGIN----DApaLAQADvgiamgSGT 539
                          570
                   ....*....|....*....
gi 1907117575  799 AIDSEAIPIKLAHDSLEDL 817
Cdd:cd02079    540 DVAIETADIVLLSNDLSKL 558
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
264-785 2.90e-17

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 87.15  E-value: 2.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  264 STVRVsvcRENEEIEEIFSTDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTnlpnpsvdvKGmgee 343
Cdd:cd02094    139 KTARV---IRDGKEVEVPIEEVQVGDIVRV-RPGEKIPVDGVVVEGESSVDESMLTGESLPVEKK---------PG---- 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  344 qyspethkrHTLFCGTTVIQTRFytgeLVKAivVRTGFSTSKGQLVRsilypkptdfkLYRDAYL--------------- 408
Cdd:cd02094    202 ---------DKVIGGTINGNGSL----LVRA--TRVGADTTLAQIIR-----------LVEEAQGskapiqrladrvsgv 255
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  409 FLLCLVVVAGIGFIYTIInsILNEKEVQEIIIKSLDIITITVPPAL----PAAMTAGI-VYAQRrlkkvGIFCISPQRIN 483
Cdd:cd02094    256 FVPVVIAIAILTFLVWLL--LGPEPALTFALVAAVAVLVIACPCALglatPTAIMVGTgRAAEL-----GILIKGGEALE 328
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  484 ICGQLNLVCFDKTGTLTEdgldlwGIQRVenTRFLLPEDNVCSEMLvksQFVAcmatchSLTKiegvLSGDPLDlkmfEA 563
Cdd:cd02094    329 RAHKVDTVVFDKTGTLTE------GKPEV--TDVVPLPGDDEDELL---RLAA------SLEQ----GSEHPLA----KA 383
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  564 IgwileeateeetalhnrimptvVRPSKQLLPEPTTAGNQEmelfelpaiyeigivrqfpfssALQRMSVVArTLGEKRm 643
Cdd:cd02094    384 I----------------------VAAAKEKGLELPEVEDFE----------------------AIPGKGVRG-TVDGRR- 417
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  644 daYMKGAPEVVASLckpETVPVDFEKVLEDYTKQGFRVIALAhrkLESKLTwhkvqhisrdaiennmdfmGLIIMQNKLK 723
Cdd:cd02094    418 --VLVGNRRLMEEN---GIDLSALEAEALALEEEGKTVVLVA---VDGELA-------------------GLIAVADPLK 470
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907117575  724 QETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpqDKViIAEALPpkDGKVAKINW 785
Cdd:cd02094    471 PDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI----DEV-IAEVLP--EDKAEKVKK 525
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
618-953 2.05e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 84.77  E-value: 2.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  618 IVRQFPFSSALQRMSVVARTLGEKRMDAYMKGAPEVVASLCKPEtvpvDFekvLEDYT----KQGFRVIALAHRKL---- 689
Cdd:cd07541    363 ILQIFPFTSESKRMGIIVREEKTGEITFYMKGADVVMSKIVQYN----DW---LEEECgnmaREGLRTLVVAKKKLseee 435
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  690 ---------ESKLTWH----KVQHISrDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVAR 756
Cdd:cd07541    436 yqafekrynAAKLSIHdrdlKVAEVV-ESLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAK 514
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  757 DCGMILPQDKVIIAEALPPKDGkvakinwhytdslsqcsessaidseaipiklAHDSLEDLEVTRYH-FAMNGKSFSVIL 835
Cdd:cd07541    515 SSKLVSRGQYIHVFRKVTTREE-------------------------------AHLELNNLRRKHDCaLVIDGESLEVCL 563
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  836 EHFQDLVPKLMLHGT--VFARMAPDQKTQLVEALQNVDYFVGMC-GDGANDCGALKRAHGGISLSELE---ASVASPFts 909
Cdd:cd07541    564 KYYEHEFIELACQLPavVCCRCSPTQKAQIVRLIQKHTGKRTCAiGDGGNDVSMIQAADVGVGIEGKEgkqASLAADF-- 641
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907117575  910 ktpSISCVPNLIR----EGR-----AALMTSFCVFKFM------ALYSIIQYFSVTLLY 953
Cdd:cd07541    642 ---SITQFSHIGRlllwHGRnsykrSAKLAQFVMHRGLiisimqAVFSSVFYFAPIALY 697
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
212-781 4.17e-15

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 80.01  E-value: 4.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  212 YIFQLFSVIL-----WSVDEYYYYALA--IVIMSVVSIISSLYSIRKQYVM--LHDMVATHSTVrvsvCRENEEIEEIFS 282
Cdd:TIGR01511   32 YGYSLVALLAnqvltGLHVHTFFDASAmlITFILLGRWLEMLAKGRASDALskLAKLQPSTATL----LTKDGSIEEVPV 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  283 TDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKtnlpnpsvdvkgmgEEQyspethkrHTLFCGTTVI 362
Cdd:TIGR01511  108 ALLQPGDIVKV-LPGEKIPVDGTVIEGESEVDESLVTGESLPVPK--------------KVG--------DPVIAGTVNG 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  363 QTRFYtgelVKAivVRTGFSTSKGQLVRSILYPKPTDFKLYRDA-----YLFLLCLVV--VAGIGFIYTIINSIlnekev 435
Cdd:TIGR01511  165 TGSLV----VRA--TATGEDTTLAQIVRLVRQAQQSKAPIQRLAdkvagYFVPVVIAIalITFVIWLFALEFAV------ 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  436 qeiiikslDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEdgldlwGIQRVENT 515
Cdd:TIGR01511  233 --------TVLIIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQ------GKPTVTDV 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  516 RFLlpednvcSEMlVKSQFVACMAtchSLTKIegvlSGDPLdlkmfeAIGwileeateeetalhnrimptVVRPSKQLLP 595
Cdd:TIGR01511  299 HVF-------GDR-DRTELLALAA---ALEAG----SEHPL------AKA--------------------IVSYAKEKGI 337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  596 EPTTAGNQEmelfelpAIYEIGIvrqfpfssalqrmsvvaRTLGEKRMdaYMKGAPEvvasLCKPETVPVDfEKVLEDYT 675
Cdd:TIGR01511  338 TLVTVSDFK-------AIPGIGV-----------------EGTVEGTK--IQLGNEK----LLGENAIKID-GKAGQGST 386
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  676 kqgfRVIALAHRKLeskltwhkvqhisrdaiennmdfMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVA 755
Cdd:TIGR01511  387 ----VVLVAVNGEL-----------------------AGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVA 439
                          570       580       590
                   ....*....|....*....|....*....|.
gi 1907117575  756 RDCGM-----ILPQDKVIIAEALPPKDGKVA 781
Cdd:TIGR01511  440 KELGIdvraeVLPDDKAALIKKLQEKGPVVA 470
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
248-783 1.79e-12

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 71.68  E-value: 1.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  248 SIRKqyvmLHDMVATHSTVRvsvcRENEEIEeIFSTDLVPGDVMII-PlnGTVMPCDAVLINGTCIVNESMLTGESVPVT 326
Cdd:cd07545     86 SIRS----LMDIAPKTALVR----RDGQERE-VPVAEVAVGDRMIVrP--GERIAMDGIIVRGESSVNQAAITGESLPVE 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  327 KtnlpnpsvdvkGMGEEqyspethkrhtLFCGTT----VIQTRF--YTGELVKAIVVRTgfsTSKGQLVRSilypkPTD- 399
Cdd:cd07545    155 K-----------GVGDE-----------VFAGTLngegALEVRVtkPAEDSTIARIIHL---VEEAQAERA-----PTQa 204
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  400 ----FKLYRDAYLFLLCLVVVagigfiytIINSILNEKEVQEIIIKSLDIITITVPPAL----PAAMTAGIVYAQRR--L 469
Cdd:cd07545    205 fvdrFARYYTPVVMAIAALVA--------IVPPLFFGGAWFTWIYRGLALLVVACPCALvistPVSIVSAIGNAARKgvL 276
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  470 KKVGIFcispqrINICGQLNLVCFDKTGTLTEdgldlwGIQRVenTRFLLPEDNVCSEMLVksqfvacMATchSLTKieg 549
Cdd:cd07545    277 IKGGVY------LEELGRLKTVAFDKTGTLTK------GKPVV--TDVVVLGGQTEKELLA-------IAA--ALEY--- 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  550 vLSGDPLdlkmfeaigwileeateeetalhnriMPTVVRPSKQllpepttagnqemELFELPAiyeigiVRQFpfsSALQ 629
Cdd:cd07545    331 -RSEHPL--------------------------ASAIVKKAEQ-------------RGLTLSA------VEEF---TALT 361
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  630 RMSVVARTLGekrmDAYMKGAPEVVASLCKPETVPvdFEKVLEDYTKQGFRVIALAHRKleskltwhkvqhisrdaienn 709
Cdd:cd07545    362 GRGVRGVVNG----TTYYIGSPRLFEELNLSESPA--LEAKLDALQNQGKTVMILGDGE--------------------- 414
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  710 mDFMGLIIMQNKLKQETPAVLEDLHKANI-RTVMVTGDNMLTAVSVARDCGM------ILPQDKVIIAEALPPKDGKVAK 782
Cdd:cd07545    415 -RILGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQVGVsdiraeLLPQDKLDAIEALQAEGGRVAM 493

                   .
gi 1907117575  783 I 783
Cdd:cd07545    494 V 494
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
213-896 2.13e-12

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 72.00  E-value: 2.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  213 IFQLFSVILW--------------------SVDEYYyyaLAIVIMSVVSI--ISSLYSIRKQY-VM--LHDMVATHSTVr 267
Cdd:cd02608     35 LFGGFSMLLWigailcflaygiqaateeepSNDNLY---LGIVLAAVVIVtgCFSYYQEAKSSkIMdsFKNMVPQQALV- 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  268 vsvCRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLING-TCIVNESMLTGESVPVTKtnlpnpsvdvkgmgeeqyS 346
Cdd:cd02608    111 ---IRDGEKMQ-INAEELVVGDLVEVK-GGDRIPADIRIISAhGCKVDNSSLTGESEPQTR------------------S 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  347 PE-THK-----RHTLFCGTTVIQTrfyTGelvKAIVVRTGFSTSKGQL--VRSILYPKPTdfKLYRDAYLFLLCLVVVA- 417
Cdd:cd02608    168 PEfTHEnpletKNIAFFSTNCVEG---TA---RGIVINTGDRTVMGRIatLASGLEVGKT--PIAREIEHFIHIITGVAv 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  418 --GIGFIytIINSILnEKEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDK 495
Cdd:cd02608    240 flGVSFF--ILSLIL-GYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDK 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  496 TGTLTEDGLD---LWGIQRVENTRFLLPEDNvcsemlvkSQFVACMATCHSLTKIEGVLsgdpldlkmfeaigwileeat 572
Cdd:cd02608    317 TGTLTQNRMTvahMWFDNQIHEADTTEDQSG--------ASFDKSSATWLALSRIAGLC--------------------- 367
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  573 eeetalhNRimpTVVRPSKQLLPEP--TTAGNQ---------EMELFELPAIYEIGI-VRQFPFSSALQ-RMSVVART-L 638
Cdd:cd02608    368 -------NR---AEFKAGQENVPILkrDVNGDAsesallkciELSCGSVMEMRERNPkVAEIPFNSTNKyQLSIHENEdP 437
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  639 GEKRMDAYMKGAPEVVASLC-----KPETVPVD------FEKVLEDYTKQGFRVIALAHRKLESKLTWHKVQHisrDAIE 707
Cdd:cd02608    438 GDPRYLLVMKGAPERILDRCstiliNGKEQPLDeemkeaFQNAYLELGGLGERVLGFCHLYLPDDKFPEGFKF---DTDE 514
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  708 -----NNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMIlpqdkviiaealppkdgkvak 782
Cdd:cd02608    515 vnfptENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII--------------------- 573
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  783 inwhytdslsqcsessaidseaipiklahdsledlevtryhfamngksfsvilehfqdlvpklmlhgtVFARMAPDQKTQ 862
Cdd:cd02608    574 --------------------------------------------------------------------VFARTSPQQKLI 585
                          730       740       750
                   ....*....|....*....|....*....|....
gi 1907117575  863 LVEALQNVDYFVGMCGDGANDCGALKRAHGGISL 896
Cdd:cd02608    586 IVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 619
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
276-783 1.11e-10

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 65.79  E-value: 1.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  276 EIEEIFSTDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKtnlpNPSVDVKGmgeeqyspethkrhtl 355
Cdd:cd07552    140 SIEDVPVSELKVGDVVLV-RAGEKIPADGTILEGESSVNESMVTGESKPVEK----KPGDEVIG---------------- 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  356 fcGTTviqtrfYTGELVKAIVVRTGFSTSKGQLVRSILYPK--PTDFKLYRD---AYLFLLCLvVVAGIGFI-YTIINSi 429
Cdd:cd07552    199 --GSV------NGNGTLEVKVTKTGEDSYLSQVMELVAQAQasKSRAENLADkvaGWLFYIAL-GVGIIAFIiWLILGD- 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  430 lnekeVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGI 509
Cdd:cd07552    269 -----LAFALERAVTVLVIACPHALGLAIPLVVARSTSIAAKNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDV 343
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  510 QRVENTRfllpednvcsemlvKSQFVACMATchsltkIEGvLSGDPLdlkmfeAIGwileeateeetalhnrimptVVRP 589
Cdd:cd07552    344 ITFDEYD--------------EDEILSLAAA------LEA-GSEHPL------AQA--------------------IVSA 376
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  590 SKQLLPEPTTAGNQEmelfelpAIYEIGIvrqfpfssalqrmsvvARTLGEKRmdaYMKGAPEVVASLckpeTVPVDfEK 669
Cdd:cd07552    377 AKEKGIRPVEVENFE-------NIPGVGV----------------EGTVNGKR---YQVVSPKYLKEL----GLKYD-EE 425
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  670 VLEDYTKQGFRVIALahrkleskltwhkvqhisrdaIENNmDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNML 749
Cdd:cd07552    426 LVKRLAQQGNTVSFL---------------------IQDG-EVIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEE 483
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1907117575  750 TAVSVARDCGM------ILPQDKVIIAEALPPKDGKVAKI 783
Cdd:cd07552    484 VAQAVAEELGIdeyfaeVLPEDKAKKVKELQAEGKKVAMV 523
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
273-773 1.57e-10

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 65.40  E-value: 1.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  273 ENEEIEEIFSTDLVPGDVMIIPLNGTvMPCDAVLINGTCIVNESMLTGESVPVTKTnlpnpsvdvkgmgeeqyspethkr 352
Cdd:PRK11033   249 RDGEREEVAIADLRPGDVIEVAAGGR-LPADGKLLSPFASFDESALTGESIPVERA------------------------ 303
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  353 htlfcgttviqtrfyTGELVKAivvrtGfSTSKGQLVRSILYPKPTD------FKLYRDA-----------------Y-- 407
Cdd:PRK11033   304 ---------------TGEKVPA-----G-ATSVDRLVTLEVLSEPGAsaidriLHLIEEAeerrapierfidrfsriYtp 362
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  408 -LFLLCLVVVagigfiytIINSILNEKEVQEIIIKSLDIITITVPPAL----PAAMTAGIVYAQRR--LKKVGifcispQ 480
Cdd:PRK11033   363 aIMLVALLVI--------LVPPLLFAAPWQEWIYRGLTLLLIGCPCALvistPAAITSGLAAAARRgaLIKGG------A 428
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  481 RINICGQLNLVCFDKTGTLTEDGLDLWGIQRVENtrflLPEDnvcsEMLVKSQFVAcMATCHSLTKiegvlsgdpldlkm 560
Cdd:PRK11033   429 ALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATG----ISES----ELLALAAAVE-QGSTHPLAQ-------------- 485
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  561 feaigwileeateeetalhnrimpTVVRPSKQLLPEPTTAGNQEmelfelpaiyeigivrqfpfssALQRMSVVARTLGE 640
Cdd:PRK11033   486 ------------------------AIVREAQVRGLAIPEAESQR----------------------ALAGSGIEGQVNGE 519
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  641 KrmdaYMKGAPEVVASLckpetvPVDFEKVLEDYTKQGFRVIALAHrkleskltwhkvqhisrdaienNMDFMGLIIMQN 720
Cdd:PRK11033   520 R----VLICAPGKLPPL------ADAFAGQINELESAGKTVVLVLR----------------------NDDVLGLIALQD 567
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907117575  721 KLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGM-----ILPQDKVIIAEAL 773
Cdd:PRK11033   568 TLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGIdfragLLPEDKVKAVTEL 625
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
273-783 1.76e-10

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 65.12  E-value: 1.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  273 ENEEIEEIFSTDLVPGDVMIIPLNGTVmPCDAVLINGTCIVNESMLTGESVPVTktnlpnpsvdvKGMGEEqyspethkr 352
Cdd:cd07546    105 ENGERREVPADSLRPGDVIEVAPGGRL-PADGELLSGFASFDESALTGESIPVE-----------KAAGDK--------- 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  353 htLFCGTTViqtrfyTGELVKAIVVRTGFSTSKGQLVRSILYPK----PTDFKLYRDAYLFLLCLVVVAgigFIYTIINS 428
Cdd:cd07546    164 --VFAGSIN------VDGVLRIRVTSAPGDNAIDRILHLIEEAEerraPIERFIDRFSRWYTPAIMAVA---LLVIVVPP 232
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  429 ILNEKEVQEIIIKSLDIITITVPPAL----PAAMTAGIVYAQRR--LKKVGifcispQRINICGQLNLVCFDKTGTLTEd 502
Cdd:cd07546    233 LLFGADWQTWIYRGLALLLIGCPCALvistPAAITSGLAAAARRgaLIKGG------AALEQLGRVTTVAFDKTGTLTR- 305
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  503 gldlwGIQRVENTRFLLPEDNvcSEMLVKSQFVAcMATCHSLTKiegvlsgdpldlkmfeAIgwileeateeetalhnri 582
Cdd:cd07546    306 -----GKPVVTDVVPLTGISE--AELLALAAAVE-MGSSHPLAQ----------------AI------------------ 343
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  583 mptVVRPSKQLLPEPTTagnQEmelfelpaiyeigivrqfpfssalqrmsvvARTLGEKRMDAYMKGAPEVVASLCKPET 662
Cdd:cd07546    344 ---VARAQAAGLTIPPA---EE------------------------------ARALVGRGIEGQVDGERVLIGAPKFAAD 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  663 -VPVDFEKVLEDYTKQGFRVIALAhrkleskltwhkvqhisrdaieNNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTV 741
Cdd:cd07546    388 rGTLEVQGRIAALEQAGKTVVVVL----------------------ANGRVLGLIALRDELRPDAAEAVAELNALGIKAL 445
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1907117575  742 MVTGDNMLTAVSVARDCGM-----ILPQDKVIIAEALPPKdGKVAKI 783
Cdd:cd07546    446 MLTGDNPRAAAAIAAELGLdfragLLPEDKVKAVRELAQH-GPVAMV 491
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
261-783 2.99e-10

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 64.59  E-value: 2.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  261 ATHSTVRVSVCRENEEIEEIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCIVNESMLTGESVPVtktnlpnpsvdVKGM 340
Cdd:cd02078     90 KTKTETQAKRLRNDGKIEKVPATDLKKGDIVLVE-AGDIIPADGEVIEGVASVDESAITGESAPV-----------IRES 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  341 GEEqyspethkRHTLFCGTTVIQTRFYT------GE--LVKAIVVRTGFSTSK--GQLVRSILYpkptdfklyrdAYLFL 410
Cdd:cd02078    158 GGD--------RSSVTGGTKVLSDRIKVritanpGEtfLDRMIALVEGASRQKtpNEIALTILL-----------VGLTL 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  411 LCLVVVAGIGFIYTIINSILNekeVQEIIIKSLDIITITVPPALPAAMTAGIvyaqRRLKKVGIFCISPQRINICGQLNL 490
Cdd:cd02078    219 IFLIVVATLPPFAEYSGAPVS---VTVLVALLVCLIPTTIGGLLSAIGIAGM----DRLLRFNVIAKSGRAVEAAGDVDT 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  491 VCFDKTGTLTedgldlwgIQRVENTRFlLPEDNVCSEMLVKsqfVACMATCHSLTKiEGVlsgdpldlkmfeaigwilee 570
Cdd:cd02078    292 LLLDKTGTIT--------LGNRQATEF-IPVGGVDEKELAD---AAQLASLADETP-EGR-------------------- 338
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  571 ateeetalhnrimpTVVRPSKQLLpepttagnqEMELFELPAIYEIgivrqFPFsSALQRMSVVARTLGEKrmdaYMKGA 650
Cdd:cd02078    339 --------------SIVILAKQLG---------GTERDLDLSGAEF-----IPF-SAETRMSGVDLPDGTE----IRKGA 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  651 PEVVASLCKPE--TVPVDFEKVLEDYTKQGFRVIALAHrkleskltwhkvqhisrdaienNMDFMGLIIMQNKLKQETPA 728
Cdd:cd02078    386 VDAIRKYVRSLggSIPEELEAIVEEISKQGGTPLVVAE----------------------DDRVLGVIYLKDIIKPGIKE 443
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907117575  729 VLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpqDKvIIAEALPpkDGKVAKI 783
Cdd:cd02078    444 RFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DD-FLAEAKP--EDKLELI 491
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
247-821 3.03e-10

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 64.60  E-value: 3.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  247 YSIRKQYVMLHDMVATHSTvRVSVCRENEEIEeIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCIVNESMLTGESVPVt 326
Cdd:cd07550     82 YTARKSEKALLDLLSPQER-TVWVERDGVEVE-VPADEVQPGDTVVVG-AGDVIPVDGTVLSGEALIDQASLTGESLPV- 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  327 ktnlpnpsvdVKGMGEEQYSpethkrhtlfcGTTVIqtrfyTGELVkaIVV-RTGFSTSKGQLVRSI---LYPKpTDFKL 402
Cdd:cd07550    158 ----------EKREGDLVFA-----------STVVE-----EGQLV--IRAeRVGRETRAARIAELIeqsPSLK-ARIQN 208
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  403 YRDAYLFLLCLVVVAGIGFIYTIINSIlnekeVQEIIIKSLDI---ITITVPPALPAAMTagivYAQRRlkkvGIFCISP 479
Cdd:cd07550    209 YAERLADRLVPPTLGLAGLVYALTGDI-----SRAAAVLLVDFscgIRLSTPVAVLSALN----HAARH----GILVKGG 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  480 QRINICGQLNLVCFDKTGTLTEDGLdlwGIQRVEntrfllPEDNVCSEmlvksQFVACMATC------HSLTkiegvlsg 553
Cdd:cd07550    276 RALELLAKVDTVVFDKTGTLTEGEP---EVTAII------TFDGRLSE-----EDLLYLAASaeehfpHPVA-------- 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  554 dpldlkmfEAIgwileeateeetalhnrimptvVRpskqllpeptTAGNQEMELFEL-PAIYEIGivrqfpfssalqrmS 632
Cdd:cd07550    334 --------RAI----------------------VR----------EAEERGIEHPEHeEVEYIVG--------------H 359
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  633 VVARTLGEKRMdayMKGAPEVVASLCKPETVPVDfeKVLEDYTKQGFRVIALAhrkleskltwhkvqhISRDAIennmdf 712
Cdd:cd07550    360 GIASTVDGKRI---RVGSRHFMEEEEIILIPEVD--ELIEDLHAEGKSLLYVA---------------IDGRLI------ 413
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  713 mGLIIMQNKLKQETPAVLEDLHKANIRTV-MVTGDNMLTAVSVARDCGM------ILPQDKVIIAEALPPKDGKVAKINW 785
Cdd:cd07550    414 -GVIGLSDPLRPEAAEVIARLRALGGKRIiMLTGDHEQRARALAEQLGIdryhaeALPEDKAEIVEKLQAEGRTVAFVGD 492
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 1907117575  786 HYTDS--LSQC------SESSAIDSEAIPIKLAHDSLEDLEVTR 821
Cdd:cd07550    493 GINDSpaLSYAdvgismRGGTDIARETADVVLLEDDLRGLAEAI 536
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
272-501 1.22e-09

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 62.53  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  272 RENEEIEEIFS--TDLVPGDVMIIpLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKtnlpnpsvdvkgmgeeqyspet 349
Cdd:cd07553    131 IETGSGSRIKTraDQIKSGDVYLV-ASGQRVPVDGKLLSEQASIDMSWLTGESLPRIV---------------------- 187
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  350 HKRHTLFCGTTVIQTRF-----------YTGELVKAIVVRTGFSTSKGQLVRSIlypkptdfklyrdAYLFLLCLVVVAG 418
Cdd:cd07553    188 ERGDKVPAGTSLENQAFeirvehslaesWSGSILQKVEAQEARKTPRDLLADKI-------------IHYFTVIALLIAV 254
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  419 IGFIYTI---INSILNekevqeiiiKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDK 495
Cdd:cd07553    255 AGFGVWLaidLSIALK---------VFTSVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDK 325

                   ....*.
gi 1907117575  496 TGTLTE 501
Cdd:cd07553    326 TGTLTR 331
PLN03190 PLN03190
aminophospholipid translocase; Provisional
624-980 7.80e-09

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 60.30  E-value: 7.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  624 FSSALQRMSVVartLG--EKRMDAYMKGAPEVVASLCKPE---TVPVDFEKVLEDYTKQGFRVIALAHRKL-ESKL-TWH 696
Cdd:PLN03190   611 FDSDRKRMSVI---LGcpDKTVKVFVKGADTSMFSVIDRSlnmNVIRATEAHLHTYSSLGLRTLVVGMRELnDSEFeQWH 687
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  697 ------KVQHISRDA--------IENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMIL 762
Cdd:PLN03190   688 fsfeaaSTALIGRAAllrkvasnVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYSSKLLT 767
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  763 PQDKVIIaealppkdgkvakINWHYTDSLSQCSESSAIDSEAIPI--KLAHDSLEDLEVTRYHFAM--NGKSFSVILE-H 837
Cdd:PLN03190   768 NKMTQII-------------INSNSKESCRKSLEDALVMSKKLTTvsGISQNTGGSSAAASDPVALiiDGTSLVYVLDsE 834
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  838 FQDLVPKLMLHGTVF--ARMAPDQKTQLVEALQN-VDYFVGMCGDGANDCGALKRAHGGISLSEleasvaspftsktpsi 914
Cdd:PLN03190   835 LEEQLFQLASKCSVVlcCRVAPLQKAGIVALVKNrTSDMTLAIGDGANDVSMIQMADVGVGISG---------------- 898
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907117575  915 scvpnliREGRAALMTS-FCVFKFMALYSII--------QYFSVTLLYSILSNLgdfQFLFIDLAIILVVVFTMS 980
Cdd:PLN03190   899 -------QEGRQAVMASdFAMGQFRFLVPLLlvhghwnyQRMGYMILYNFYRNA---VFVLVLFWYVLFTCFTLT 963
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
278-767 1.49e-08

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 58.94  E-value: 1.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  278 EEIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCIVNESMLTGESVPVTKtnlpnpsvdvkgmgeeqyspETHKRHTLFC 357
Cdd:PRK14010   116 EMIDASDLKKGHIVRVA-TGEQIPNDGKVIKGLATVDESAITGESAPVIK--------------------ESGGDFDNVI 174
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  358 GTTVIQTRFYTGELVKAivVRTGFSTSKGQLVRSILYPK-PTDFKLYrdAYLFLLCLVVVAGIGFIYTIINSILNEKEVQ 436
Cdd:PRK14010   175 GGTSVASDWLEVEITSE--PGHSFLDKMIGLVEGATRKKtPNEIALF--TLLMTLTIIFLVVILTMYPLAKFLNFNLSIA 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  437 EIIIKSLDIITITVPPALPAAMTAGIvyaqRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGIQRVENTR 516
Cdd:PRK14010   251 MLIALAVCLIPTTIGGLLSAIGIAGM----DRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYGNRMADAFIPVKSSS 326
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  517 FllpednvcsEMLVKSQFVACMATchslTKIEGvlsgdpldlkmfeaigwileeateeetalhnrimPTVVRPSKQL-LP 595
Cdd:PRK14010   327 F---------ERLVKAAYESSIAD----DTPEG----------------------------------RSIVKLAYKQhID 359
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  596 EPTTAGnqemelfelpaiyeigivRQFPFSsALQRMSVVARTLGEkrmdaYMKGAPEVVASLCKPET--VPVDFEKVLED 673
Cdd:PRK14010   360 LPQEVG------------------EYIPFT-AETRMSGVKFTTRE-----VYKGAPNSMVKRVKEAGghIPVDLDALVKG 415
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  674 YTKQGFRVIALahrkleskltwhkvqhisrdaIENNMdFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVS 753
Cdd:PRK14010   416 VSKKGGTPLVV---------------------LEDNE-ILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAAT 473
                          490       500
                   ....*....|....*....|
gi 1907117575  754 VARDCGM------ILPQDKV 767
Cdd:PRK14010   474 IAKEAGVdrfvaeCKPEDKI 493
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
618-658 9.05e-08

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 51.07  E-value: 9.05e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907117575  618 IVRQFPFSSALQRMSVVARTLGEKRMDAYMKGAPEVVASLC 658
Cdd:pfam13246   48 RVAEIPFNSDRKRMSTVHKLPDDGKYRLFVKGAPEIILDRC 88
copA PRK10671
copper-exporting P-type ATPase CopA;
715-783 8.03e-07

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 53.59  E-value: 8.03e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907117575  715 LIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMilpqDKViIAEALPpkDGKVAKI 783
Cdd:PRK10671   644 LLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI----DEV-IAGVLP--DGKAEAI 705
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
648-771 5.97e-06

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 48.35  E-value: 5.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  648 KGAPEVVASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLESKLTW-----------HKVQHISRDAIENNMDFMGLI 716
Cdd:pfam00702   14 DGEPVVTEAIAELASEHPLAKAIVAAAEDLPIPVEDFTARLLLGKRDWleeldilrglvETLEAEGLTVVLVELLGVIAL 93
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907117575  717 IMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAE 771
Cdd:pfam00702   94 ADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGD 148
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
243-781 1.12e-05

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 49.54  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  243 ISSLYSIRKQYVMLhdmvathstvrvsvcRENEEIEEIFSTDLVPGDVMII-PlnGTVMPCDAVLINGTCIVNESMLTGE 321
Cdd:cd07548    100 IKALLDIRPDYANL---------------KRNNELKDVKPEEVQIGDIIVVkP--GEKIPLDGVVLKGESFLDTSALTGE 162
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  322 SVPVTKTnlPNPSVdVKGMgeeqyspethkrhtlFCGTTVIQ---TRFYTGELVKAIV--VRTGfSTSKGQLVRSIlypk 396
Cdd:cd07548    163 SVPVEVK--EGSSV-LAGF---------------INLNGVLEikvTKPFKDSAVAKILelVENA-SARKAPTEKFI---- 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  397 pTDF-KLYRDAYLFLLCLVVVagigfIYTIInsiLNEKEVQEIIIKSLDIITITVPPAL----PAAMTAGIVYAQRRlkk 471
Cdd:cd07548    220 -TKFaRYYTPIVVFLALLLAV-----IPPLF---SPDGSFSDWIYRALVFLVISCPCALvisiPLGYFGGIGAASRK--- 287
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  472 vGIFCISPQRINICGQLNLVCFDKTGTLTEdgldlwGIQRVENtrfLLPEDNVCSEMLVKsqfVACMATCHSltkiegvl 551
Cdd:cd07548    288 -GILIKGSNYLEALSQVKTVVFDKTGTLTK------GVFKVTE---IVPAPGFSKEELLK---LAALAESNS-------- 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  552 sgdpldlkmfeaigwileeateeetalHNRIMPTVVRpskqllpepttAGNQEMELFELPAIYEIGivrqfpfssalqrm 631
Cdd:cd07548    347 ---------------------------NHPIARSIQK-----------AYGKMIDPSEIEDYEEIA-------------- 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  632 svvartlGekrmdaymKGapevVASLCKPETVPVDFEKVLEDYTkqgfrvIALAHRKLEskltwHKVQHISRDAIennmd 711
Cdd:cd07548    375 -------G--------HG----IRAVVDGKEILVGNEKLMEKFN------IEHDEDEIE-----GTIVHVALDGK----- 419
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907117575  712 FMGLIIMQNKLKQETPAVLEDLHKANI-RTVMVTGDNMLTAVSVARDCGM------ILPQDKVIIAEALPPK-DGKVA 781
Cdd:cd07548    420 YVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTGDRKSVAEKVAKKLGIdevyaeLLPEDKVEKVEELKAEsKGKVA 497
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
261-500 1.83e-05

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 48.89  E-value: 1.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  261 ATHSTVRVSVCRENEEIEEIFSTDLVPGDVMIIPlNGTVMPCDAVLINGTCIVNESMLTGESVPVTktnlpnpsVDVkgm 340
Cdd:cd02092    121 AALEARGAQRLQADGSREYVPVAEIRPGDRVLVA-AGERIPVDGTVVSGTSELDRSLLTGESAPVT--------VAP--- 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  341 geeqyspethkrhtlfcGTTViqtrfYTGEL-VKAIVVRTGFSTSKGQLVRSIL------------YPKPTDfklyRDAY 407
Cdd:cd02092    189 -----------------GDLV-----QAGAMnLSGPLRLRATAAGDDTLLAEIArlmeaaeqgrsrYVRLAD----RAAR 242
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  408 LFLLCLVVVAGIGFIYTIINSIlnekEVQEIIIKSLDIITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQ 487
Cdd:cd02092    243 LYAPVVHLLALLTFVGWVAAGG----DWRHALLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRGVLVKDGTALERLAE 318
                          250
                   ....*....|...
gi 1907117575  488 LNLVCFDKTGTLT 500
Cdd:cd02092    319 VDTVVFDKTGTLT 331
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
174-221 7.44e-05

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 41.78  E-value: 7.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1907117575  174 GLTQGMHAYRKLIYGVNEIA-VKVPSVFKLLIKEVLNPFYIFQLFSVIL 221
Cdd:pfam00690   20 GLTEAEAEKRLKKYGPNELPeKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
164-222 1.39e-04

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 41.41  E-value: 1.39e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575   164 CASLYEKHSAGLTQGMHAYRKLIYGVNEIAVKV-PSVFKLLIKEVLNPFYIFQLFSVILW 222
Cdd:smart00831   13 LERLQTDLEKGLSSEEAARRLERYGPNELPPPKkTSPLLRFLRQFHNPLIYILLAAAVLS 72
thrH PRK13582
bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH;
854-894 2.30e-03

bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH;


Pssm-ID: 237437 [Multi-domain]  Cd Length: 205  Bit Score: 40.68  E-value: 2.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907117575  854 RMaPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGI 894
Cdd:PRK13582   128 RQ-PDGKRQAVKALKSLGYRVIAAGDSYNDTTMLGEADAGI 167
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
853-944 5.24e-03

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 41.19  E-value: 5.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117575  853 ARMAPDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGIS-LSELEAS-VASPFTSKTPSISCVPNLIREGRAALMT 930
Cdd:cd02092    478 AGLTPAEKVARIEELKAQGRRVLMVGDGLNDAPALAAAHVSMApASAVDASrSAADIVFLGDSLAPVPEAIEIARRARRL 557
                           90
                   ....*....|....
gi 1907117575  931 SFCVFKFMALYSII 944
Cdd:cd02092    558 IRQNFALAIGYNVI 571
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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