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Conserved domains on  [gi|1907109353|ref|XP_036014989|]
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ribosome biogenesis protein BOP1 isoform X1 [Mus musculus]

Protein Classification

WD repeat BOP1/ERB1 family ribosome biogenesis protein( domain architecture ID 12224376)

WD repeat BOP1/ERB1 family ribosome biogenesis protein is a component of a complex that is required for maturation of ribosomal RNAs and formation of the 60S ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0003676|GO:0043021|GO:0006364
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 1-227 7.52e-148

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


:

Pssm-ID: 214986  Cd Length: 264  Bit Score: 425.97  E-value: 7.52e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353    1 MDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPAVDFFSGDIMIHPVTNRPADKRSFIPSLVEKEK 80
Cdd:smart01035  32 IDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYVEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKK 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353   81 VSRMVHAIKMGWIKPRRP------HDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLPTEEERSA 154
Cdd:smart01035 112 IMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRIIMHIPAPKLPLPGHAESYNPPPEYLPTEEEKKE 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907109353  155 WMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFP 227
Cdd:smart01035 192 WEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQRRNKLNIDPESLLPKLPSPKDLRPFP 264
WD40 COG2319
WD40 repeat [General function prediction only];
233-569 2.75e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTV-HVGGVVRSIAWNPNPTIcLVAAAMDDAVLLLNPAl 311
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLA- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 312 gdrllvgsTDQLLEAFTPpeepalqparwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTqVLLHQV 391
Cdd:COG2319   193 --------TGKLLRTLTG----------------------------HTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 392 SRRRSQSPFRRSHGQVQCVAFHPSRPFLLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLV 470
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 471 WFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdlGVLDVA 550
Cdd:COG2319   314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHTG----AVTSVA 379

                         330
                  ....*....|....*....
gi 1907109353 551 FHPTQPWVFSSGADGTIRL 569
Cdd:COG2319   380 FSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 1-227 7.52e-148

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 425.97  E-value: 7.52e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353    1 MDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPAVDFFSGDIMIHPVTNRPADKRSFIPSLVEKEK 80
Cdd:smart01035  32 IDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYVEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKK 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353   81 VSRMVHAIKMGWIKPRRP------HDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLPTEEERSA 154
Cdd:smart01035 112 IMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRIIMHIPAPKLPLPGHAESYNPPPEYLPTEEEKKE 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907109353  155 WMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFP 227
Cdd:smart01035 192 WEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQRRNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 1-227 1.99e-147

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 424.64  E-value: 1.99e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353   1 MDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPAVDFFSGDIMIHPVTNRPADKRSFIPSLVEKEK 80
Cdd:pfam08145  32 MDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYVEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353  81 VSRMVHAIKMGWIKPRRPHDPTPSFYDLWAQEDPNAVLGRHKM-HVPAPKLALPGHAESYNPPPEYLPTEEERSAWMQQE 159
Cdd:pfam08145 112 VMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPAPKLPLPGHAESYNPPPEYLPTEEERKKWEEMD 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907109353 160 PVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFP 227
Cdd:pfam08145 192 PEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLNIDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
233-569 2.75e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTV-HVGGVVRSIAWNPNPTIcLVAAAMDDAVLLLNPAl 311
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLA- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 312 gdrllvgsTDQLLEAFTPpeepalqparwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTqVLLHQV 391
Cdd:COG2319   193 --------TGKLLRTLTG----------------------------HTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 392 SRRRSQSPFRRSHGQVQCVAFHPSRPFLLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLV 470
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 471 WFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdlGVLDVA 550
Cdd:COG2319   314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHTG----AVTSVA 379

                         330
                  ....*....|....*....
gi 1907109353 551 FHPTQPWVFSSGADGTIRL 569
Cdd:COG2319   380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-571 1.29e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 1.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKT--VHVGGVvRSIAWNPNpTICLVAAAMDDAVLLLNPa 310
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlkGHTGPV-RDVAASAD-GTYLASGSSDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 311 lgdrllvgSTDQLLEAFTppeepalqparwlevseeehqrglrlriCHSKPVTQVTWHGRGDYLAvvlSSQEHTQVLLHQ 390
Cdd:cd00200    81 --------ETGECVRTLT----------------------------GHTSYVSSVAFSPDGRILS---SSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 391 VSRRRSQSPFRrSH-GQVQCVAFHPSRPFLLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSK 468
Cdd:cd00200   122 VETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 469 L-VWfdlDLST-KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHTLtrdlGV 546
Cdd:cd00200   201 IkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGHTN----SV 264

                         330       340
                  ....*....|....*....|....*
gi 1907109353 547 LDVAFHPTQPWVFSSGADGTIRLFS 571
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
233-266 1.34e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 1.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 266
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-266 2.18e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 2.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907109353  233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 266
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 1-227 7.52e-148

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 425.97  E-value: 7.52e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353    1 MDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPAVDFFSGDIMIHPVTNRPADKRSFIPSLVEKEK 80
Cdd:smart01035  32 IDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYVEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKK 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353   81 VSRMVHAIKMGWIKPRRP------HDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLPTEEERSA 154
Cdd:smart01035 112 IMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRIIMHIPAPKLPLPGHAESYNPPPEYLPTEEEKKE 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907109353  155 WMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFP 227
Cdd:smart01035 192 WEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQRRNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 1-227 1.99e-147

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 424.64  E-value: 1.99e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353   1 MDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPAVDFFSGDIMIHPVTNRPADKRSFIPSLVEKEK 80
Cdd:pfam08145  32 MDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYVEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353  81 VSRMVHAIKMGWIKPRRPHDPTPSFYDLWAQEDPNAVLGRHKM-HVPAPKLALPGHAESYNPPPEYLPTEEERSAWMQQE 159
Cdd:pfam08145 112 VMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPAPKLPLPGHAESYNPPPEYLPTEEERKKWEEMD 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907109353 160 PVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFP 227
Cdd:pfam08145 192 PEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLNIDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
233-569 2.75e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTV-HVGGVVRSIAWNPNPTIcLVAAAMDDAVLLLNPAl 311
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLA- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 312 gdrllvgsTDQLLEAFTPpeepalqparwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTqVLLHQV 391
Cdd:COG2319   193 --------TGKLLRTLTG----------------------------HTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 392 SRRRSQSPFRRSHGQVQCVAFHPSRPFLLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLV 470
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 471 WFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdlGVLDVA 550
Cdd:COG2319   314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHTG----AVTSVA 379

                         330
                  ....*....|....*....
gi 1907109353 551 FHPTQPWVFSSGADGTIRL 569
Cdd:COG2319   380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-571 1.29e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 1.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKT--VHVGGVvRSIAWNPNpTICLVAAAMDDAVLLLNPa 310
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlkGHTGPV-RDVAASAD-GTYLASGSSDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 311 lgdrllvgSTDQLLEAFTppeepalqparwlevseeehqrglrlriCHSKPVTQVTWHGRGDYLAvvlSSQEHTQVLLHQ 390
Cdd:cd00200    81 --------ETGECVRTLT----------------------------GHTSYVSSVAFSPDGRILS---SSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 391 VSRRRSQSPFRrSH-GQVQCVAFHPSRPFLLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSK 468
Cdd:cd00200   122 VETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 469 L-VWfdlDLST-KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHTLtrdlGV 546
Cdd:cd00200   201 IkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGHTN----SV 264

                         330       340
                  ....*....|....*....|....*
gi 1907109353 547 LDVAFHPTQPWVFSSGADGTIRLFS 571
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
230-571 3.02e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 3.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 230 QALVYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKT-VHVGGVVRSIAWNPNpticlvaaamddavllln 308
Cdd:COG2319    70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPD------------------ 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 309 palGDRLLVGSTD---QLLEAFTPPEEPALQParwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTq 385
Cdd:COG2319   132 ---GKTLASGSADgtvRLWDLATGKLLRTLTG--------------------HSGAVTSVAFSPDGKLLAS--GSDDGT- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 386 VLLHQVSRRRSQSPFRRSHGQVQCVAFHPSRPFLLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGS 464
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 465 YDSKLVWFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdl 544
Cdd:COG2319   266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGHTG---- 331

                         330       340
                  ....*....|....*....|....*..
gi 1907109353 545 GVLDVAFHPTQPWVFSSGADGTIRLFS 571
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
326-571 6.95e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 6.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 326 AFTPPEEPALQPARWLEVSEEEHQRGLRLRICHSKPVTQVTWHGRGDYLAVVLSSQEHTQVLLHQVSRRRSQsPFRRSHG 405
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-TLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 406 QVQCVAFHPSRPFLLVAS-QRSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLVWFDLDlSTKPYKVL 484
Cdd:COG2319    80 AVLSVAFSPDGRLLASASaDGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 485 RHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVLDVAFHPTQPWVFSSGAD 564
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGHT----GAVRSVAFSPDGKLLASGSAD 225


                  ....*..
gi 1907109353 565 GTIRLFS 571
Cdd:COG2319   226 GTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-571 7.95e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 7.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109353 480 PYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVLDVAFHPTQPWVF 559
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELL---RTLKGHT----GPVRDVAASADGTYLA 67

                          90
                  ....*....|..
gi 1907109353 560 SSGADGTIRLFS 571
Cdd:cd00200    68 SGSSDKTIRLWD 79
WD40 pfam00400
WD domain, G-beta repeat;
233-266 1.34e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 1.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 266
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-266 2.18e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 2.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907109353  233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 266
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
233-269 1.00e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 1.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907109353 233 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVAT 269
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 477-514 3.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907109353  477 STKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 514
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
531-571 5.62e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.62e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907109353 531 PVKVLKGHTLtrdlGVLDVAFHPTQPWVFSSGADGTIRLFS 571
Cdd:pfam00400   3 LLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 531-571 8.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 8.95e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907109353  531 PVKVLKGHTLtrdlGVLDVAFHPTQPWVFSSGADGTIRLFS 571
Cdd:smart00320   4 LLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
479-514 1.72e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907109353 479 KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 514
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 235-271 2.23e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.52  E-value: 2.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907109353 235 RGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATAR 271
Cdd:pfam20426 121 RQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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