Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907135258   48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907135258 2070 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2113
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907135258 1551 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPSVNTSEYKILC 1591
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907135258  343 GRCSNQLPQSITKMQCCCD-LGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1328 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1363
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907135258 1196 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1237
Cdd:cd01475    183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1907135258   615 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907135258  1932 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1974
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907135258  1115 DIDECQRDPLLCRGGICHNTEGSYRCECPPGHQLSPN 1151
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907135258  1650 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1689
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907135258 2015 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2045
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907135258  1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1640
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907135258  1489 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1520
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1975 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2010
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907135258   767 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 798
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907135258  1072 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1106
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907135258   492 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 523
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907135258   48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907135258 2070 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2113
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907135258 1551 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPSVNTSEYKILC 1591
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907135258  343 GRCSNQLPQSITKMQCCCD-LGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1328 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1363
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907135258 1196 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1237
Cdd:cd01475    183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1203 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1238
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1907135258   615 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907135258  2129 DMDECKEPDVCRHG-QCINTDGSYRCECPFGYIlEGNECV 2167
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907135258  2168 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2207
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907135258  615 DINECETPGICMN-GRCVNTDGSYRCECFPG 644
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907135258  1365 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTgDGFTCT 1405
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907135258   574 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 614
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907135258  1650 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1689
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1324 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIGD 1359
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907135258  862 GRCEININGATLKSECC-SSLGAAWGSPCTIC 892
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907135258  1324 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIgDGIKCT 1364
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907135258 1768 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1798
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907135258   288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907135258  1489 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1520
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258  574 DMDECSIRNMCLN-GMCINEDGSFKCICKPGFQLAS 608
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907135258 1489 DVNECLDPTTC-ISGNCVNTPGSYTCDCPPDFEL 1521
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907135258 1650 DVNECETPGICGP-GTCYNTVGNYTCICPPDYM 1681
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907135258  1768 DIDECrEIPGVCENG-VCINMVGSFRCECPVGF 1799
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1448 DIDECSLPNICVF-GTCHNLPGLFRCECEIGYELDR 1482
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907135258 1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1641
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907135258  1072 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1106
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907135258  1157 DINECElSANLCPHG-RCVNLIGKYQCACNPGYH 1189
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907135258  246 DVDECQAIPGMC-QGGNCINTVGSFECKCPAG 276
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907135258   492 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 523
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907135258   48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907135258 2070 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2113
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907135258 1551 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPSVNTSEYKILC 1591
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907135258  343 GRCSNQLPQSITKMQCCCD-LGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1328 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1363
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907135258 1196 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1237
Cdd:cd01475    183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907135258 1203 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1238
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36