NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907093804|ref|XP_036013949|]
View 

centromere protein H isoform X3 [Mus musculus]

Protein Classification

centromere protein H( domain architecture ID 10530763)

centromere protein H (CENP-H) is a component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CENP-H pfam05837
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 29-142 1.57e-25

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


:

Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 93.42  E-value: 1.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093804  29 LTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTE 108
Cdd:pfam05837   1 LLPLINRRDELSSAILKLSSELRELQEELTEVEKENLRLKRKNRELAAELLELAKEKESRREDPKLRAQLEKLEAELKKS 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907093804 109 IKITTVVQHTFQGLILASKTNWAEDPALRETVLQ 142
Cdd:pfam05837  81 RRRWRVMKNVASAIIVGSGVDWAEDEKLRELVLD 114
 
Name Accession Description Interval E-value
CENP-H pfam05837
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 29-142 1.57e-25

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 93.42  E-value: 1.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093804  29 LTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTE 108
Cdd:pfam05837   1 LLPLINRRDELSSAILKLSSELRELQEELTEVEKENLRLKRKNRELAAELLELAKEKESRREDPKLRAQLEKLEAELKKS 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907093804 109 IKITTVVQHTFQGLILASKTNWAEDPALRETVLQ 142
Cdd:pfam05837  81 RRRWRVMKNVASAIIVGSGVDWAEDEKLRELVLD 114
 
Name Accession Description Interval E-value
CENP-H pfam05837
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 29-142 1.57e-25

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 93.42  E-value: 1.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093804  29 LTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTE 108
Cdd:pfam05837   1 LLPLINRRDELSSAILKLSSELRELQEELTEVEKENLRLKRKNRELAAELLELAKEKESRREDPKLRAQLEKLEAELKKS 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907093804 109 IKITTVVQHTFQGLILASKTNWAEDPALRETVLQ 142
Cdd:pfam05837  81 RRRWRVMKNVASAIIVGSGVDWAEDEKLRELVLD 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH