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Conserved domains on  [gi|1907086055|ref|XP_036013094|]
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latent-transforming growth factor beta-binding protein 2 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 532-572 1.12e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907086055 532 CSQILGQNSTQAECCC-TQGARWGKACAPCPSEDSVEFSQLC 572
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 702-745 1.61e-06

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 45.73  E-value: 1.61e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907086055 702 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 745
Cdd:pfam00683   1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
412-445 3.35e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907086055  412 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 445
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
39-69 1.96e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.96e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086055   39 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGY 69
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
119-150 3.54e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.54e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086055  119 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 150
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
327-358 4.18e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.18e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086055  327 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 358
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
285-326 2.03e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907086055  285 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFasaEGGTRCQ 326
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
244-284 2.36e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907086055  244 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQlvNGTMCE 284
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
883-917 7.68e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086055  883 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 917
Cdd:smart00179   1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1-30 2.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907086055   1 MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 30
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 79-114 4.36e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.36e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907086055  79 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 114
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 202-232 9.53e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam07645:

Pssm-ID: 473889  Cd Length: 32  Bit Score: 34.52  E-value: 9.53e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 202 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 232
Cdd:pfam07645   1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 532-572 1.12e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907086055 532 CSQILGQNSTQAECCC-TQGARWGKACAPCPSEDSVEFSQLC 572
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 702-745 1.61e-06

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 45.73  E-value: 1.61e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907086055 702 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 745
Cdd:pfam00683   1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
412-445 3.35e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907086055  412 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 445
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 412-444 4.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 4.48e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 412 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 444
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
39-69 1.96e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.96e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086055   39 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGY 69
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
119-150 3.54e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.54e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086055  119 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 150
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
327-358 4.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.18e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086055  327 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 358
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 39-70 4.96e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 4.96e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055  39 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 70
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 119-150 1.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.42e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 119 DVNECLTPGIC-THGRCINMEGSFRCSCEPGYE 150
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 327-358 1.80e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.80e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 327 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 358
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
285-326 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907086055  285 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFasaEGGTRCQ 326
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
244-284 2.36e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907086055  244 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQlvNGTMCE 284
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
327-356 3.71e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 3.71e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 327 DVDECA-ATDPCP-GGHCVNTEGSFSCLCETG 356
Cdd:pfam07645   1 DVDECAtGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
244-274 4.43e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 4.43e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 244 DVDECEGPQSSC-RGGECKNTEGSYQCLCHQG 274
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
883-917 7.68e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086055  883 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 917
Cdd:smart00179   1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 285-316 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 285 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGF 316
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1-30 2.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907086055   1 MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 30
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 244-279 2.30e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907086055 244 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVN 279
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
412-442 2.50e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 2.50e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 412 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 442
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1-27 3.75e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.75e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907086055    1 MRNPCEGRGRCVNSVGSYSCLCYPGYT 27
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 79-114 4.36e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.36e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907086055  79 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 114
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 883-917 8.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907086055 883 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 917
Cdd:cd00054     1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
202-232 9.53e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.52  E-value: 9.53e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 202 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 232
Cdd:pfam07645   1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 532-572 1.12e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907086055 532 CSQILGQNSTQAECCC-TQGARWGKACAPCPSEDSVEFSQLC 572
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 702-745 1.61e-06

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 45.73  E-value: 1.61e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907086055 702 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 745
Cdd:pfam00683   1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
412-445 3.35e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907086055  412 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 445
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 412-444 4.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 4.48e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 412 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 444
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
39-69 1.96e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.96e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086055   39 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGY 69
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
119-150 3.54e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.54e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086055  119 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 150
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
327-358 4.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.18e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086055  327 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 358
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 39-70 4.96e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 4.96e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055  39 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 70
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 119-150 1.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.42e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 119 DVNECLTPGIC-THGRCINMEGSFRCSCEPGYE 150
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 327-358 1.80e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.80e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 327 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 358
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
285-326 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907086055  285 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFasaEGGTRCQ 326
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
244-284 2.36e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907086055  244 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQlvNGTMCE 284
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
327-356 3.71e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 3.71e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 327 DVDECA-ATDPCP-GGHCVNTEGSFSCLCETG 356
Cdd:pfam07645   1 DVDECAtGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
244-274 4.43e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 4.43e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 244 DVDECEGPQSSC-RGGECKNTEGSYQCLCHQG 274
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
883-917 7.68e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086055  883 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 917
Cdd:smart00179   1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 285-316 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 285 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGF 316
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1-30 2.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907086055   1 MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 30
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 244-279 2.30e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907086055 244 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVN 279
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
412-442 2.50e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 2.50e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907086055 412 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 442
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1-27 3.75e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.75e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907086055    1 MRNPCEGRGRCVNSVGSYSCLCYPGYT 27
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 79-114 4.36e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.36e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907086055  79 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 114
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF smart00181
Epidermal growth factor-like domain;
122-150 7.19e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.19  E-value: 7.19e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907086055  122 ECLTPGICTHGRCINMEGSFRCSCEPGYE 150
Cdd:smart00181   1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 883-917 8.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907086055 883 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 917
Cdd:cd00054     1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
202-232 9.53e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.52  E-value: 9.53e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907086055 202 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 232
Cdd:pfam07645   1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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