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Conserved domains on  [gi|1907086052|ref|XP_036013093|]
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latent-transforming growth factor beta-binding protein 2 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 685-728 2.62e-14

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 67.69  E-value: 2.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907086052  685 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 728
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
938-977 4.68e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 4.68e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907086052   938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYImvRKGHCQ 977
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1018-1049 1.11e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.11e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052  1018 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 1049
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 895-929 9.72e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 9.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086052  895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 929
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-655 1.09e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.09e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907086052   626 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 655
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 978-1013 1.72e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907086052  978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 1013
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 565-599 1.06e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086052  565 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 599
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 852-887 5.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907086052  852 DFDPCFAGasNICGP-GTCVSLPNGYRCVCSPGYQLH 887
Cdd:cd00054      1 DIDECASG--NPCQNgGTCVNTVGSYRCSCPPGYTGR 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 685-728 2.62e-14

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 67.69  E-value: 2.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907086052  685 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 728
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
938-977 4.68e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 4.68e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907086052   938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYImvRKGHCQ 977
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1018-1049 1.11e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.11e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052  1018 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 1049
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 938-969 1.80e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.80e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086052  938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 969
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1018-1049 6.13e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 6.13e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086052 1018 DVNECLTPGIC-THGRCINMEGSFRCSCEPGYE 1049
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 895-929 9.72e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 9.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086052  895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 929
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
895-926 1.96e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.96e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052   895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYT 926
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-655 1.09e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.09e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907086052   626 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 655
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 978-1013 1.72e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907086052  978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 1013
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 626-659 3.46e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907086052  626 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 659
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
938-967 8.27e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 8.27e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052  938 DIDECEQPG-VC-SGGRCSNTEGSYHCECDRG 967
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
978-1009 1.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.43e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052   978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1009
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1018-1047 6.44e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.44e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052 1018 DVNECLTPG-IC-THGRCINMEGSFRCSCEPG 1047
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 565-599 1.06e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086052  565 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 599
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 899-926 1.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.86e-03
                           10        20
                   ....*....|....*....|....*...
gi 1907086052  899 CMRNPCEGRGRCVNSVGSYSCLCYPGYT 926
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF_CA pfam07645
Calcium-binding EGF domain;
626-655 2.25e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.25e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052  626 DINECLTLG-LCKDSE-CVNTRGSYLCTCRPG 655
Cdd:pfam07645    1 DVDECATGThNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 852-887 5.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907086052  852 DFDPCFAGasNICGP-GTCVSLPNGYRCVCSPGYQLH 887
Cdd:cd00054      1 DIDECASG--NPCQNgGTCVNTVGSYRCSCPPGYTGR 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 685-728 2.62e-14

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 67.69  E-value: 2.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907086052  685 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 728
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
938-977 4.68e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 4.68e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907086052   938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYImvRKGHCQ 977
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1018-1049 1.11e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.11e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052  1018 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 1049
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 938-969 1.80e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.80e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086052  938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 969
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1018-1049 6.13e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 6.13e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086052 1018 DVNECLTPGIC-THGRCINMEGSFRCSCEPGYE 1049
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 895-929 9.72e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 9.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086052  895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 929
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
895-926 1.96e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.96e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052   895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYT 926
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-655 1.09e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.09e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907086052   626 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 655
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 978-1013 1.72e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907086052  978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 1013
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 626-659 3.46e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907086052  626 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 659
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
938-967 8.27e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 8.27e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052  938 DIDECEQPG-VC-SGGRCSNTEGSYHCECDRG 967
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
1021-1049 1.20e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 1.20e-04
                            10        20
                    ....*....|....*....|....*....
gi 1907086052  1021 ECLTPGICTHGRCINMEGSFRCSCEPGYE 1049
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
978-1009 1.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.43e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907086052   978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1009
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32
EGF smart00181
Epidermal growth factor-like domain;
941-972 3.95e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.65  E-value: 3.95e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907086052   941 ECEQPGVCSGGRCSNTEGSYHCECDRGYIMVR 972
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDK 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1018-1047 6.44e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.44e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052 1018 DVNECLTPG-IC-THGRCINMEGSFRCSCEPG 1047
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 565-599 1.06e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907086052  565 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 599
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 898-929 1.11e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907086052  898 EC-MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 929
Cdd:cd00053      1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 941-977 1.58e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907086052  941 ECEQPGVCS-GGRCSNTEGSYHCECDRGYImvRKGHCQ 977
Cdd:cd00053      1 ECAASNPCSnGGTCVNTPGSYRCVCPPGYT--GDRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 899-926 1.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.86e-03
                           10        20
                   ....*....|....*....|....*...
gi 1907086052  899 CMRNPCEGRGRCVNSVGSYSCLCYPGYT 926
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF_CA pfam07645
Calcium-binding EGF domain;
626-655 2.25e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.25e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052  626 DINECLTLG-LCKDSE-CVNTRGSYLCTCRPG 655
Cdd:pfam07645    1 DVDECATGThNCPANTvCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1021-1049 4.76e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 4.76e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907086052 1021 ECLTPGICTH-GRCINMEGSFRCSCEPGYE 1049
Cdd:cd00053      1 ECAASNPCSNgGTCVNTPGSYRCVCPPGYT 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 852-887 5.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907086052  852 DFDPCFAGasNICGP-GTCVSLPNGYRCVCSPGYQLH 887
Cdd:cd00054      1 DIDECASG--NPCQNgGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
895-924 5.95e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 5.95e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907086052  895 DDNECM--RNPCEGRGRCVNSVGSYSCLCYPG 924
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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