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Conserved domains on  [gi|1907082429|ref|XP_036012736|]
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contactin-associated protein 1 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
747-882 1.01e-27

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.01e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   747 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 825
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082429   826 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 882
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 26-177 1.92e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.96  E-value: 1.92e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   26 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 104
Cdd:cd00110      1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907082429  105 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 177
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 451-601 4.63e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.41  E-value: 4.63e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  451 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 529
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  530 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 601
Cdd:cd00110     74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 259-280 1.06e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.06e-05
                           10        20
                   ....*....|....*....|..
gi 1907082429  259 SGNYTIDPDGSGPLKPFVVYCD 280
Cdd:NF040941    14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
968-986 1.60e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.60e-05
                            10
                    ....*....|....*....
gi 1907082429   968 FYLQNHRYKGSYHTNEPKA 986
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 248-322 5.80e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 42.61  E-value: 5.80e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082429  248 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 322
Cdd:cd00087      5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 208-237 3.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907082429  208 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 237
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
747-882 1.01e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.01e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   747 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 825
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082429   826 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 882
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 752-882 1.20e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 108.66  E-value: 1.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  752 FSTNSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 831
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907082429  832 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 882
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 26-177 1.92e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.96  E-value: 1.92e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   26 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 104
Cdd:cd00110      1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907082429  105 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 177
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 736-880 2.91e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.58  E-value: 2.91e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  736 YRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 814
Cdd:cd00110     12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907082429  815 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 880
Cdd:cd00110     90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
49-179 2.10e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 99.72  E-value: 2.10e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429    49 VSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 128
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1907082429   129 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 179
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 53-179 2.66e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 2.66e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   53 FRTWDLTGLLLFSHlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 132
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907082429  133 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 179
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 451-601 4.63e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.41  E-value: 4.63e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  451 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 529
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  530 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 601
Cdd:cd00110     74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 477-603 2.35e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.64  E-value: 2.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  477 FRTSAPSGVFLENMGGpfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 556
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907082429  557 HRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 603
Cdd:pfam02210   73 GQTVVSSLPPGESLLLNL-NGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
472-603 3.04e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.56  E-value: 3.04e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   472 DVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 551
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   552 RLRVDHRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 603
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNL-DGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 259-280 1.06e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.06e-05
                           10        20
                   ....*....|....*....|..
gi 1907082429  259 SGNYTIDPDGSGPLKPFVVYCD 280
Cdd:NF040941    14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
968-986 1.60e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.60e-05
                            10
                    ....*....|....*....
gi 1907082429   968 FYLQNHRYKGSYHTNEPKA 986
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 248-322 5.80e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 42.61  E-value: 5.80e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082429  248 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 322
Cdd:cd00087      5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
245-289 2.81e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.58  E-value: 2.81e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907082429  245 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 289
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 208-237 3.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907082429  208 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 237
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 244-303 6.67e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 39.18  E-value: 6.67e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907082429   244 LYKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIRENR-AWTVVRHdrlwttRVTGS 303
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGgGWTVIQR------RMDGS 53
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
747-882 1.01e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.01e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   747 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 825
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082429   826 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 882
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 752-882 1.20e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 108.66  E-value: 1.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  752 FSTNSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 831
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907082429  832 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 882
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 26-177 1.92e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.96  E-value: 1.92e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   26 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 104
Cdd:cd00110      1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907082429  105 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 177
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 736-880 2.91e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.58  E-value: 2.91e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  736 YRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 814
Cdd:cd00110     12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907082429  815 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 880
Cdd:cd00110     90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
49-179 2.10e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 99.72  E-value: 2.10e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429    49 VSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 128
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1907082429   129 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 179
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 53-179 2.66e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 2.66e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   53 FRTWDLTGLLLFSHlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 132
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907082429  133 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 179
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 451-601 4.63e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.41  E-value: 4.63e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  451 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 529
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  530 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 601
Cdd:cd00110     74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 477-603 2.35e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.64  E-value: 2.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  477 FRTSAPSGVFLENMGGpfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 556
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907082429  557 HRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 603
Cdd:pfam02210   73 GQTVVSSLPPGESLLLNL-NGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
472-603 3.04e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.56  E-value: 3.04e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   472 DVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 551
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   552 RLRVDHRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 603
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNL-DGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
53-182 5.51e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.96  E-value: 5.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429   53 FRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDveGAEV 132
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSY-DLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG--EARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907082429  133 RVSYPL----LIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVN 182
Cdd:pfam00054   78 TGESPLgattDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
477-606 6.33e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 61.18  E-value: 6.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  477 FRTSAPSGVFLENMGGPFcrwrRPYVRVELNTSRdVVFAFDIGNGDEnLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 556
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE----RDFLALELRDGR-LEVSYDLGSGAA-VVRSGD--KLNDGKWHSVELERNGRSGTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907082429  557 HRPWVLRPMPLQTYIWLVYDQPLYVGSA----ELKRR-----PFVGCLRAMRLNGVTLN 606
Cdd:pfam00054   73 GEARPTGESPLGATTDLDVDGPLYVGGLpslgVKKRRlaispSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
752-882 8.88e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.41  E-value: 8.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082429  752 FSTNSAPAVLLYVSSFV-RDYMAVLIKeDGTLQLRYQLGTSPyVYQLTTRPVTDGQPHSVNITRVYRNLFIQVD--YFPL 828
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELR-DGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVDgeARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907082429  829 TEQKFSllVDSQLDSPKALYLGRvMETGVIDPEIQRyNTPGFSGCLSGVRFNNV 882
Cdd:pfam00054   79 GESPLG--ATTDLDVDGPLYVGG-LPSLGVKKRRLA-ISPSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 259-280 1.06e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.06e-05
                           10        20
                   ....*....|....*....|..
gi 1907082429  259 SGNYTIDPDGSGPLKPFVVYCD 280
Cdd:NF040941    14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
968-986 1.60e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.60e-05
                            10
                    ....*....|....*....
gi 1907082429   968 FYLQNHRYKGSYHTNEPKA 986
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 248-322 5.80e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 42.61  E-value: 5.80e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082429  248 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 322
Cdd:cd00087      5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
245-289 2.81e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.58  E-value: 2.81e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907082429  245 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 289
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 208-237 3.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907082429  208 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 237
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 244-303 6.67e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 39.18  E-value: 6.67e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907082429   244 LYKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIRENR-AWTVVRHdrlwttRVTGS 303
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGgGWTVIQR------RMDGS 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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