|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
108-508 |
0e+00 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 513.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFT-------------------------- 161
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTaplstvlsnrfghrpvvmvggllisl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 162 ----------------------GLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17422 81 gmitasfassivemyltigiisGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17422 161 LVVGALQLNIVVCGALLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17422 179 ------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAG 459
Cdd:cd17422 235 RISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALG 314
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1907079528 460 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17422 315 VYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
108-508 |
7.99e-86 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 270.19 E-value: 7.99e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTF--------------------------- 160
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFsgplssalvnrfgcrpvaiaggllaal 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 161 ---------------------TGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17352 81 glllssfatslwqlyltygvlGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17352 179 ------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAG 459
Cdd:cd17352 235 RILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILA--DLVGLEKLSNAYG 312
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1907079528 460 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17352 313 LVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
103-544 |
9.24e-59 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 202.28 E-value: 9.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 103 PDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVL------------------------ 158
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLyaggpissilvnrfgcrpvviagg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 159 ------------------------TFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 214
Cdd:TIGR00892 92 llaslgmilasfssnvielyltagFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 215 WRYSLLFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelTTSPKNVPSEAK- 293
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPV------------------------------------------GPSQRVSKSKSKe 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 294 -MEQETRAEQQQTLVTAPKHSQmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTM 372
Cdd:TIGR00892 210 gLPPDGSTKKLSKKSTAEKINR----FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSII 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 373 AIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVG 450
Cdd:TIGR00892 286 GFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLthLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DLVG 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 451 IEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVRPCkkglCQNSHSGENQTDRQRG 530
Cdd:TIGR00892 364 AQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYI----NYRLLAKEQKAALERE 439
|
490
....*....|....*.
gi 1907079528 531 KAL--QDIPEDFLEMD 544
Cdd:TIGR00892 440 GARdkKDAEGDSRESE 455
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
108-504 |
4.13e-51 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 179.90 E-value: 4.13e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTF--------------------------- 160
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLaspvgsalstrygarpvvmlggllssl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 161 ---------------------TGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17423 81 gfllasfatsllhlylcigllSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPG-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17423 185 --------DPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVG 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAG 459
Cdd:cd17423 257 RLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPE--LVGVERVLNATG 334
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1907079528 460 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 504
Cdd:cd17423 335 LLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
108-506 |
4.88e-36 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 138.32 E-value: 4.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVL----------------------------- 158
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLygtgplcsilvnrfgcrpvmlvggllasl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 159 -------------------TFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17430 81 gmilasfctsiiqlyltagVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17430 180 --------------------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSA 457
Cdd:cd17430 240 RPACGVVAGLKWVRPRVVYLFSFAMLFNGLtdLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMA--IVGTQKFSSA 317
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1907079528 458 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 506
Cdd:cd17430 318 IGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
108-506 |
8.26e-36 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 137.60 E-value: 8.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVL----------------------------- 158
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLhaggplcsilverfgcrvtvmlggllsgv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 159 -------------------TFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17425 81 gmvassfshsivqlyftagFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRPF------------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsvLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17425 181 -------------------------CSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFM 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGfVLNREPI---RKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS 456
Cdd:cd17425 236 RPLAG-LLSGLPVfkgRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM--DTVEMDRFPS 312
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1907079528 457 AAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 506
Cdd:cd17425 313 ALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
108-504 |
1.35e-29 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 119.92 E-value: 1.35e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVL----------------------------- 158
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMyaggpissilvnkygsrpvviaggllcsl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 159 -------------------TFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17427 81 gmisasfcnsvmqlylcigVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPIiiqGPgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL---GP------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17427 183 ------------------------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIR---------KIYIELICVILLtaslfafTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVG 450
Cdd:cd17427 239 RPSMGLVANSKWIRpriqyffsfAVMYNGVCHLLC-------PLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM--DLVG 309
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1907079528 451 IEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 504
Cdd:cd17427 310 AQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
108-507 |
1.82e-29 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 119.54 E-value: 1.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISI---------------------------------- 153
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSImsslrlsagplasvacgrlgerwtsilgaflvsa 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 154 --------------CVFVLTFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAvFAFAPAITALKEHIGWRYSL 219
Cdd:cd17421 81 gflisifatsvpflYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLT-FALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI------------------------------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkapllDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17421 180 ---------------------DFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAG 459
Cdd:cd17421 239 QLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLV--DLVGVTKVNSSLG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1907079528 460 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 507
Cdd:cd17421 317 FSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLE 364
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
108-504 |
2.93e-29 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 119.21 E-value: 2.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVL----------------------------- 158
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMyaggpissilvnkygsrpimiaggclsga 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 159 -------------------TFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17426 81 gliaasfcntveglyfcvgVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPI------------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtAPKhsqmkaPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17426 181 ---------GPK------PFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVA 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIR-KI-YIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSA 457
Cdd:cd17426 246 RPSMGIVANTKWVRpRIqYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLM--DLVGAQRFSSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1907079528 458 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 504
Cdd:cd17426 324 VGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
108-508 |
2.38e-25 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 107.59 E-value: 2.38e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISI--CVFVL--------------------------- 158
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIvdCTTMLcaplgslisnhlscqvgiilggllast 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 159 -------------------TFTGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17424 81 glilssfatsleylyltlgVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 379
Cdd:cd17424 185 ------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKI--YIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGgTHIPMLAEDdVVGIEKMSSA 457
Cdd:cd17424 235 NITFGWLTDRRCLKKYryFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYV-ALIPVVTSD-VVGTSSLSSA 312
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1907079528 458 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17424 313 LGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
109-508 |
3.79e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 92.64 E-value: 3.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 109 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTF---------------------------- 160
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALlriplgflvdrfgprrvlligllllgig 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 161 -------------------TGLGYCFSFLPTVTILSQYFDK-RRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLL 220
Cdd:COG2223 84 llllalavsywlllllgllLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 221 FVGLLQLNIMVCGALLrpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKmeqetra 300
Cdd:COG2223 164 ILGILLLVVAVLAWLF--------------------------------------------LRDPPAGAAAAAK------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 301 eqqqtlvtAPKHSQMKAplldfsvLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFG 379
Cdd:COG2223 193 --------ASLRDQLEA-------LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 380 RIGAGFVLNREPIRKIYieLICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAA 458
Cdd:COG2223 258 RPLGGWLSDRIGGRRVL--LIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP--DIFPTKNAGAVY 333
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1907079528 459 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 508
Cdd:COG2223 334 GLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
108-509 |
1.12e-17 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 84.88 E-value: 1.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWI------------------ISIC--------------- 154
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWIsslsmgitlivgpfiglfINTCgcrktaiiggiltsl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 155 ----------VFVLTFT-----GLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17429 81 gwvlsayatnVHYLFISfgvtaGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVF 378
Cdd:cd17429 179 ------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIF 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 379 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggTHIPMLAEdDVVGIEKMSSAA 458
Cdd:cd17429 235 GKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYF--SLMPVVTE-DLVGIKNLANAY 311
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1907079528 459 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLaLVRP 509
Cdd:cd17429 312 GIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICL-LLKP 361
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
108-506 |
1.60e-17 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 84.48 E-value: 1.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWI--------------ISICV------------------ 155
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVgslasgvgliaspvCSACVssfgarpvtifsgfmvag 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 156 -----------FVLTFT-----GLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17428 81 glmlsafapniYFLIFSygivvGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVF 378
Cdd:cd17428 179 ------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAI 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 379 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGgthIPMLAEDDVVGIEKMSSAA 458
Cdd:cd17428 235 GKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS---IFPYVTTKTVGIEKLGHAY 311
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1907079528 459 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 506
Cdd:cd17428 312 GILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
105-509 |
3.80e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 83.00 E-value: 3.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 105 GGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISI------------------------------- 153
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAfflgyalgqipaglladrfgrrrvlaiglll 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 154 -------CVFVLTFT---------GLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWR 216
Cdd:COG2271 85 wglatllFGFATSFWqllllrfllGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 217 YSLLFVGLlqlnIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeq 296
Cdd:COG2271 165 AAFLILGL----PGLLLALLR----------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 297 etraeqqqtlvtapkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLYIIP-LGISLGIDPDRAAFLLSTMAIA 375
Cdd:COG2271 182 ---------------------------------FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLA 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 376 EVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMS 455
Cdd:COG2271 229 GIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKARG 306
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1907079528 456 SAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRP 509
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
148-508 |
2.17e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 81.16 E-value: 2.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 148 SWIISICVFVLTFTGLGyCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLQL 227
Cdd:cd17355 91 LWQLYLLWGLLGGGGAG-TLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLAL 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 228 NIMVcgallrpiiiqgpgqspkAVTLEPRREvqymlenektrtsidsidsgvelttspknvPSEAKMEQETRAEQQQTLV 307
Cdd:cd17355 170 LVLV------------------PVLLLLRRR------------------------------PADLALRAYDDASPASPGS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 308 TAPKhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVL 387
Cdd:cd17355 202 TLKE------------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 388 NRepIRKIYIELICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQS 466
Cdd:cd17355 270 DR--YSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATVPLTAALAAR--YFGARSYGTLFGLVFAPHQ 345
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1907079528 467 ISGLAGPPLAGLLVDQSKIYSRAFYSCAAgMCLAAVCLALVR 508
Cdd:cd17355 346 LGSALGPWLGGLLYDRTGSYTAAWALAVA-LGLIAALLVLPI 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
156-509 |
4.46e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 80.30 E-value: 4.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 156 FVLTF-TGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAvFAFAPAITA-LKEHIGWRYSLLFVGLLQLNIMVcg 233
Cdd:COG2807 110 LAGTAlIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLG-AALAAGLTVpLAAALGWRGALAVWALLALLALL-- 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 234 aLLRPIIIQGPGQSPKAVTLEPRRevqymlenektrtsidsidsgvelttspknvpseakmeqetraeqqqtlvtapkhs 313
Cdd:COG2807 187 -LWLPLLRRRPAAAAAAPAAASLR-------------------------------------------------------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 314 qmkaplldfSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIR 393
Cdd:COG2807 210 ---------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 394 KIYIeLICVILLTASLFAFTFATEFWgLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvgiekmSSAAGVYVFIQSISGL 470
Cdd:COG2807 281 RPLL-LLLGLLGLAGLLGLLLAPGSL-PWLWAVLLGLGQGglfPLALTLIGLRARTP-------AEAAALSGMAQSVGYL 351
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1907079528 471 ---AGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVC-LALVRP 509
Cdd:COG2807 352 laaLGPLLVGALHDATGSWTAALLLLAALAVLMLVAgLLAGRP 394
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
108-507 |
5.94e-15 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 76.68 E-value: 5.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFV--LTFTGLGYC------------------- 166
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGmlLTQPILGFIadsfgprplmalagimvla 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 167 -FSFLP--------------------------TVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 219
Cdd:cd17314 81 gYTYLSyvfnsfplsyacfvfigagtgilygsAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 220 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 299
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 300 aeQQQTLVTAPKHSQMKAPLLDFSVLKEKSF-ICYALFGLFATlGFFAPSLYIIPLGISLGID-PDRAAFLLSTMAIAEV 377
Cdd:cd17314 180 --KEPPDNQARLHVQKKKTQTMGEIFRDKVFwILFIAIFLVLI-GGFLFIANMASLVRSLQLDaPSFVTKLMSIYGLFNA 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 378 FGRIGAGFVLNREpIRKIYIELICVILLTASLFAFTFATEF--WGLMLCSVFFGSMVGtiGGTHIPMLAEDDVVGIEKMS 455
Cdd:cd17314 257 FGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYG--GLFTVYPATVSTVFGTESFA 333
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1907079528 456 SAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 507
Cdd:cd17314 334 TLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
115-504 |
1.68e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.16 E-value: 1.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 115 FFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFtglgycFSFLptVTILSQYFDKRRSVVTAVASTG 194
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYAL------LQPL--AGLLADRFGRRPVLLLGLLLFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 195 ECFAVFAFAPAITAL--------------------------KEHIGWRYSLLFVGLLQLNIMVcGALLRPIIIQGPGQSP 248
Cdd:cd06174 73 LGALLFAFAPSFWLLllgrfllglgsglidpavlaliadlfPERERGRALGLLQAFGSVGGIL-GPLLGGILASSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 249 KAVTLeprrevqymlenektrtsIDSIDSGVELTTSPKNVPSEAKMEQETRAEQQQTLVTAPKhsqmkaplldFSVLKEK 328
Cdd:cd06174 152 RAVFL------------------IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL----------KRVLKNP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 329 SFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIELICVILL 405
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKplLLIGLLLMALG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 406 TASLFAFTFATEFWGLMLCSVFFGSMVGTIggthiPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 485
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPL-----SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358
|
410
....*....|....*....
gi 1907079528 486 YSRAFYSCAAGMCLAAVCL 504
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
328-509 |
1.75e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 1.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 328 KSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTA 407
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 408 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYS 487
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA--DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|..
gi 1907079528 488 rAFYSCAAGMCLAAVCLALVRP 509
Cdd:COG2814 166 -VFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
308-508 |
3.58e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 3.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 308 TAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAP--SLYIIPLGislGIDPDRAAFLLSTMAIAEVFGRIGAGF 385
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPflPLYAAELG---GLSPAQIGLLFGAQGLASALSQPPAGK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 386 VLNRePIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQ 465
Cdd:cd17325 258 LSDR-IGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA--DIVPPEGRGTAMGLFNTAF 333
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1907079528 466 SISGLAGPPLAGLLVDQSKIYSrAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17325 334 SLGMVLGPLLGGFLYDAFGFAT-PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
330-509 |
3.62e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.83 E-value: 3.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 330 FICYALFGLFATLgffAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 409
Cdd:pfam07690 2 FLAAFLAALGRSL---LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 410 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrA 489
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA--DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-A 153
|
170 180
....*....|....*....|
gi 1907079528 490 FYSCAAGMCLAAVCLALVRP 509
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
108-507 |
3.99e-12 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 67.94 E-value: 3.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-----DESNSKISWIISI--------CVFVLTFT------------- 161
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALamgmiffcSPIVSCFTdkigcrltafaga 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 162 ---------------------------GLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 214
Cdd:cd17420 81 avsfgglllssfcssigalyftygimfGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 215 WRYSLLFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKM 294
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRP------------------------------------------LHPSPEDPKSKPGR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 295 EQETRAeqqqtlvtapKHSQMKApLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAI 374
Cdd:cd17420 199 RTLHSR----------INLFLRK-IFNVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 375 AEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEK 453
Cdd:cd17420 268 TSGIGRLIFGVIADMPPgVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFE--LVGPSG 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1907079528 454 MSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 507
Cdd:cd17420 346 ASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
322-469 |
2.12e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.38 E-value: 2.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 322 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelI 400
Cdd:COG2814 201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--I 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079528 401 CVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISG 469
Cdd:COG2814 279 GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE--LAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
155-473 |
1.00e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.21 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 155 VFVLTFTGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLQLNIMVCG 233
Cdd:pfam07690 89 LVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 234 ALLRPiiiqgpgqSPKAVTLEPRREVQYMLenektrtsidsidsgvelttspknvpseakmeqetraeqqqtlvtapkhs 313
Cdd:pfam07690 169 LLPRP--------PPESKRPKPAEEARLSL-------------------------------------------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 314 qmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNR-EPI 392
Cdd:pfam07690 191 -----IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRlGRR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 393 RKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGThiPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAG 472
Cdd:pfam07690 266 RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA--LNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
.
gi 1907079528 473 P 473
Cdd:pfam07690 344 P 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
331-509 |
1.74e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.98 E-value: 1.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 331 ICYALFGLFATLGFFAPslyIIPLGI-SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 409
Cdd:cd17325 1 LSLALFLDMLGYGIIIP---ILPLYAeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL--LGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 410 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 489
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA--DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAP 152
|
170 180
....*....|....*....|
gi 1907079528 490 FYSCAAGMCLAAVCLALVRP 509
Cdd:cd17325 153 FLVCAALALLALVLALLLLP 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
310-508 |
1.95e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 310 PKHSQMKAPLLDF--SVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFV 386
Cdd:COG2211 208 PVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 387 LNREPIRKIYIelICVILLTASLFAFTFA--TEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVV-------GIEKMSSA 457
Cdd:COG2211 288 AKRFGKKKAFI--IGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLA--DVVdydewktGRRREGLY 363
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079528 458 AGVYVFIQSISGLAGPPLAGLLVD---------QSKIYSRAFYSC-----AAGMCLAAVCLALVR 508
Cdd:COG2211 364 FGIFTFAIKLGQALAGALAGLLLAlfgyvagaaQSPSALTGIRLLffllpAVLLLLAALLLLFYP 428
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
296-505 |
2.23e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.64 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 296 QETRAEQQQTLVTAPKHSQMKAPLLDFSVLKeksfICYALFGL----FATLGFFapslyIIPLGISLGIDPDRAAFLLST 371
Cdd:cd17475 172 REPPAASAATESASTLLRSLKEVLRNRDVWL----IAIAGALLvapqFALLTFL-----LLFLHDHLGLSVVAAGALLAV 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 372 MAIAEVFGRIGAGFVLNR--EPIRKIYIELI-CVILLTASLFAF-TFATEFWGLMLCSVFFGsmVGTIG--GTHIPMLAE 445
Cdd:cd17475 243 AQLGGALGRIGLGRVSDRvfGGRRRPVLVITaAIAAAALLVLSLlSPGTPLWLLVLLLILLG--LFAIGwnGLYLTLVAE 320
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 446 ddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLA 505
Cdd:cd17475 321 --SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
333-509 |
1.95e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.75 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 333 YALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAf 412
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 413 tFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSR-AFY 491
Cdd:cd06174 80 -FAPSFWLLLLGRFLLGLGSGLIDPAVLALIA--DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFL 156
|
170
....*....|....*...
gi 1907079528 492 SCAAGMCLAAVCLALVRP 509
Cdd:cd06174 157 IAAALALLAAILLLLVVP 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
334-505 |
2.40e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.11 E-value: 2.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 334 ALFGLFATlGFFAPSLY-IIPL-GISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPiRKIYIELICVILLTASLFA 411
Cdd:cd17477 193 ALLGAFVA-GFLEGAFYsLLPLyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD-RRRVLLGCALLGALAALLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 412 FTFATEFWGLMLCSVFFGSMVG---TIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiySR 488
Cdd:cd17477 271 PLVPGLPLALLVLLFLWGGAAGplyTLALALA-----GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PH 343
|
170
....*....|....*..
gi 1907079528 489 AFYSCAAGMCLAAVCLA 505
Cdd:cd17477 344 GLFLFLAAVALLFLLFL 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
322-507 |
3.42e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 3.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 322 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYI--E 398
Cdd:COG0738 204 KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRlsA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 399 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTI---GGTHIPMLAeddvvgiekmSSAAGVYVFIQSISGLAGPPL 475
Cdd:COG0738 284 LLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfslALDGLGKRT----------AAAVSAVLIMGIVGGAIGPPL 353
|
170 180 190
....*....|....*....|....*....|..
gi 1907079528 476 AGLLVDQskiysrafYSCAAGMCLAAVCLALV 507
Cdd:COG0738 354 IGFLADA--------FGLRAAFLVPLVCYLLI 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
295-507 |
1.32e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 295 EQETRAEQQQTLVTAPKHSQMKAPLLDFSVLkekSFICYalFGLFATLGFFApslyiIPLGISLGIDPDRAAFLLSTMAI 374
Cdd:cd17474 176 PKEKAKSSSATKLRDLKKALRGRGLLTFLVS---AFLYF--FLYFAFLTYLP-----FLLELLYGISPIIIGLLFAGWSV 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 375 AEVFGRIGAGFVLNREpIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKM 454
Cdd:cd17474 246 LLALGSLFVGRLLKKR-FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE--LAPEEER 322
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907079528 455 SSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrAFYSCAAGMCLAAVCLALV 507
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA-PFLVGAAIALAAAVLLALL 374
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
109-507 |
3.18e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 55.69 E-value: 3.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 109 WAVAVSFFFVeVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTF------------------------TGLG 164
Cdd:cd17353 3 WLVLLGAVLM-HLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAIsapfagrlvdrggprkailiggilFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 165 YCFS----FLPTVTILS--------------------QYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLL 220
Cdd:cd17353 82 FILSafaiSLPLLFLGYgvlggigagigyitpvstavKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 221 FVGLLQLNIMVCGALL--RPiiiqGPGQSPKAVTleprrevqymlenektrtsidsidsgvelttsPKNVPSEAKMEQET 298
Cdd:cd17353 162 ILGIIFLIIIVIGAFLirDP----PKGWVPPGVD--------------------------------PLANNAENSPRDYT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 299 RAEqqqtlvtapkhsqmkaplldfsVLKEKSFIC-YALFGLFATLGFFAPSlYIIPLGISL-GIDPDRAAFLLSTMAIAE 376
Cdd:cd17353 206 PRE----------------------MLRTPTFWLlWLMFFLNATAGLMLIG-QAKPIGQEFaGLDAGIAALAVSILSIFN 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 377 VFGRIGAGFVLNREPIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGiEKMSS 456
Cdd:cd17353 263 GGGRPFWGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTA--DFFG-TKNAG 338
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1907079528 457 AAGVYVFI-QSISGLAGPPLAGlLVDQSKIYSRAFYSCAAGMCLAAVCLALV 507
Cdd:cd17353 339 TNYGLLYTaKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
307-507 |
9.43e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.14 E-value: 9.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 307 VTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDpdRAAFLLSTMAIAEVFGRIGAGFV 386
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 387 LNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggthIPMLAED--DVVGIEKMSSAAGVYVFI 464
Cdd:cd17489 251 SDR--KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL----FPALQALavDLVPPHRRGAANGTFFIF 324
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1907079528 465 QSISGLAGPPLAGLLVDQSKiYSRAFYSCAagmCLAAVCLALV 507
Cdd:cd17489 325 FDLGIGLGGLLLGLVAELFG-YRAMFLLAA---VVVLLALVLY 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
333-509 |
1.11e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.09 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 333 YALFGLFATLGFFAPSL--YIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLF 410
Cdd:COG0738 11 IAIYLLFFLWGFATALWgpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL--LGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 411 AFTFATEFWGLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvGIEKMSSAAGVYvfiqSISGLAGPPLAGLLVDQS-KIY 486
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGlldVAANPYVAALGPET--AASRLNLLHAFF----SLGALLGPLLGGLLILLGlSLS 162
|
170 180
....*....|....*....|...
gi 1907079528 487 SRAFYSCAAGMCLAAVCLALVRP 509
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSK 185
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
317-482 |
2.13e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.35 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 317 APLLDFSVLKEKSFICYALFGLFATLGFFApSLYIIP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK 394
Cdd:cd17503 167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFG-AMFLLPlyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 395 IYIelICVILLTASLFAFTFATE---FWGLMLCSVFFGSMVG-------TIGGTHIPMlaeddvvgiEKMSSAAGVYVFI 464
Cdd:cd17503 246 LLL--AGLLLLALGTLLLAFLTPdtsLWLIILPLFIRGLGMGlvfmplnTLALNSLPP---------EQIGDATALFNTI 314
|
170
....*....|....*...
gi 1907079528 465 QSISGLAGPPLAGLLVDQ 482
Cdd:cd17503 315 RQLGGSIGTALLATLLTN 332
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
336-507 |
2.27e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.96 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 336 FGLFATLGFFapsLYIIPLGI--SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNR-EPIRKIYIELICVILLTASLFAF 412
Cdd:cd17319 189 FGINYALYGL---LTWLPTYLkqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLA 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 413 TFATEFWG--LMLCSVFFGSMVGTIGGTHIPMlaedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAF 490
Cdd:cd17319 266 YLTTSPVVavILLSLAGFGIGAASPVFWSLPA----DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAF 341
|
170
....*....|....*..
gi 1907079528 491 YSCAAGMCLAAVCLALV 507
Cdd:cd17319 342 LFLAAVALLAALLVLLL 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
323-508 |
5.13e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 5.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 323 SVLKEKSFICYALFGLFATLGFFAPSLYI-IPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelIC 401
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLpVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILM--IG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 402 VILLTASLFAFTFATEFWGLMLCSVFF--GSMvgtIGGTHIPMLAeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLL 479
Cdd:cd17329 273 ILLFAIGFAVLAFANTLAVLILAMIVLtlGEM---LVFPAVQTLV-AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348
|
170 180
....*....|....*....|....*....
gi 1907079528 480 VDQSkIYSRAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17329 349 LDLL-GPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
335-509 |
5.80e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.78 E-value: 5.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 335 LFGLFATLGFFAPSLYII-----PLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASL 409
Cdd:cd17324 1 LLALALAAFAIGTTEYVIqgllpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--LVLLLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 410 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 489
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA--DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAA 155
|
170 180
....*....|....*....|
gi 1907079528 490 FYSCAAGMCLAAVCLALVRP 509
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLP 175
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
335-504 |
9.21e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.01 E-value: 9.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 335 LFGLFATLGFFAPSLYII--PLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKiyieLICVILLTASLF 410
Cdd:cd17471 203 LLFAAFTLLFAANSMYIIamPLYVTneLGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR----LLLAGFLAGVLF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 411 --AFTFATEFWGLMLCSVFFGSMVGTIGGthIPMLAEDDVVGiEKMSSAAGVYVFIQSISGLAGPPLAGLLVdQSKIYSR 488
Cdd:cd17471 279 ylGLALATSLWQLIALQLLNAIFIGITAG--LGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIA-QYFGYRA 354
|
170
....*....|....*.
gi 1907079528 489 AFYSCAAGMCLAAVCL 504
Cdd:cd17471 355 VFLVCAVLALLALVLL 370
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
310-507 |
9.45e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 9.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 310 PKHSQMKAPLLDFSVLKEKSFICYALF-----GLFATLGFFAPSLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAG 384
Cdd:cd17333 181 PQQSVGAFSASASRLLRNPSIILGALAlflyvGAETAFSSWVPSYLVEKKHVSDGL----AGYLLSGFWVGITIGRLLGG 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 385 FVLNREPIRKiYIELICV---ILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIekmssaaGVY 461
Cdd:cd17333 257 PISRRIKPHT-LLVLSGSgalLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGT-------SVL 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1907079528 462 VFIQSISGLAGPPLAGLLVDQSKIYsRAFYsCAAGMCLAAVCLALV 507
Cdd:cd17333 329 LAAGSIGGAIIPFIMGFIAEAVGIQ-TAML-LITILYAIIFVLALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
331-511 |
1.24e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.67 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 331 ICYALFGLFATLGFFAP--SLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTAS 408
Cdd:cd17489 1 ILLANFFFFLSFYLLLPvlPLYAHDLGGSEAV----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLL--LIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 409 LFAFTFATEFWGLMLCSVFFG---SMVGTIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkI 485
Cdd:cd17489 75 TLLYLLATSVALLLVLRLIHGigwGAFTTAAATLV-----ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-G 148
|
170 180
....*....|....*....|....*.
gi 1907079528 486 YSRAFYSCAAgmcLAAVCLALVRPCK 511
Cdd:cd17489 149 FAVLFIVAAV---LALLALLLVFLVK 171
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
322-483 |
2.61e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 49.88 E-value: 2.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 322 FSVLKEKSFICYALFGLFATLGFF-----APSLYIIPLGISlgidPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY 396
Cdd:cd17320 195 KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQLGLS----PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 397 IE---LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGG--THIPMLAEDDVVGiekmsSAAGVYVFIQSISGLA 471
Cdd:cd17320 271 RLgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPnaTSLALEPFPHVAG-----TASALLGFLQFLIGAL 345
|
170
....*....|..
gi 1907079528 472 GPPLAGLLVDQS 483
Cdd:cd17320 346 AGALVGLLPNGT 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
337-502 |
3.09e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 337 GLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFAFTFAT 416
Cdd:cd06173 218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSP 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 417 EFWGLMLCSVFFGSMVGTIG---GTHIPMLAEDDVVGiekmsSAAGVYVFIQSISGLAGPPLAGLLVDQSKIySRAFYSC 493
Cdd:cd06173 296 SLWLLLAALFLLGLAGGLFNvplNTLLQLRVPDELRG-----RVFSVYNALNSGAMPLGALLAGLLADALGL-SAVFLLA 369
|
....*....
gi 1907079528 494 AAGMCLAAV 502
Cdd:cd06173 370 GALLLLAAL 378
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
329-510 |
3.42e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 49.15 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 329 SFICYALFGLFATLGFFAPSLYIIPLGISL---------------------GIDPDRAAFLLSTMAIAEVFGRIGAGFVL 387
Cdd:cd17390 153 ALLCSAIFILNAGLVWFLLSKLWDLLLVRFlmgfsvllfrsnfslyleerfDLSPKTIGYLISYSGVLGALSGFLVGRIL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 388 NREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFgSMVGTIGGTHIPMLaEDDVVGIEKMSSAAGVYVFIQSI 467
Cdd:cd17390 233 KLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL-SISSAVLRTCSTSL-LLSRGKSKERGTLLGVGQSVTSL 310
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1907079528 468 SGLAGPPLAGLLVDQSKIYSRAFyscAAGMCLAAVCLALVRPC 510
Cdd:cd17390 311 ARILAPLLSGLLQEFSVSGPGLL---GAVLALAAILLMLARQR 350
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
317-509 |
5.78e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.73 E-value: 5.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 317 APLLDFSVLKEKSFICYALFGLFATLGFFA-----PSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP 391
Cdd:cd17504 166 VPLIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 392 IRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLA 471
Cdd:cd17504 246 PRRVLL-IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE--SVPPDRTGIATGMNTVLRTIGSAI 322
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1907079528 472 GPPLAGLLVDQSKI------------YSRAFYSCAAgMCLAAVCLALVRP 509
Cdd:cd17504 323 GPAIAGAILTTYTVsitsggvptegaYVLAFLIGAA-LALAALLLSLLIP 371
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
108-491 |
5.86e-06 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 48.64 E-value: 5.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-DESNS----KISWIISI--------CVFVLTFTGLGYC-------- 166
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgSKDDAqmrfKTAWVGSLsmgmiffcSPIVSVFTDLFGCrktatgga 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 167 --------------------------------FSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 214
Cdd:cd17464 81 avgfvgllassfvssieplyftygiifacgcsFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 215 WRYSLLFVGLLQLNIMVCGALLRPIIiqgpgqspkavtlePRREvqymlenektrtsiDSIDSGVELTTSPKNvpseakm 294
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLV--------------PMKK--------------DKEGKKRKFKCPPLK------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 295 eqetraeqqqtlvtapkhsqmkaPLLDFSVLKEKSFICYAlFGLFATL-GFFAPSLYIIPLGISLGIDPDRAAFLLSTMA 373
Cdd:cd17464 206 -----------------------KIFNFNIWKSTGYRIWA-FGIPAALfGYFVPYVHLMNHVKERFGEDVNKEVLLMCIG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 374 IAEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIE 452
Cdd:cd17464 262 ITSGIGRLIFGRVADYIPgVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFE--LVGAQ 339
|
410 420 430
....*....|....*....|....*....|....*....
gi 1907079528 453 KMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFY 491
Cdd:cd17464 340 NVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFY 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
328-506 |
7.69e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 7.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 328 KSFICYALFGLFATLGFFAPSLYIiP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILL 405
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFL-PtyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 406 TASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEkmSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 485
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR--ATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|.
gi 1907079528 486 YSRAFYScAAGMCLAAVCLAL 506
Cdd:cd17316 334 TGVPALI-LALLAIVALIVAL 353
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
320-491 |
9.57e-06 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 47.87 E-value: 9.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 320 LDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP-IRKIYIE 398
Cdd:cd17465 180 LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLIPgLKKIYLQ 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 399 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGL 478
Cdd:cd17465 260 VASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFE--LVGPMQASQAIGYLLGLMAIPMTAGPPIAGL 337
|
170
....*....|...
gi 1907079528 479 LVDQSKIYSRAFY 491
Cdd:cd17465 338 LHDYFGSYHVAFY 350
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
329-508 |
3.09e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 329 SFICYALFGLFATLGFFAPSLYIiPL---GIsLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIELICVI 403
Cdd:cd17502 168 TILLSSIFGFLFGGALFGLIYYL-PLyfqLV-LGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILMS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 404 LLTASLFAFTFATEFWGLMLCSVFFGSMVGTigGTHIPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAgllvdqs 483
Cdd:cd17502 246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGI--GFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT------- 316
|
170 180
....*....|....*....|....*
gi 1907079528 484 kiysRAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17502 317 ----DVFLVALALAALAFLLSLFLP 337
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
307-508 |
3.79e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 3.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 307 VTAPKHSQMKAPLLDFSVLkeksFICYALFglfatLGFFApsLYIIPLGISL------GIDPDRAAFLLSTMAIAEVFGR 380
Cdd:cd17473 182 SAASPGAATAAALPWKRVL----PIYFLAF-----LAMLL--FYVIPIQLPFllqergGGSAALIGLALAIASLAGAIGA 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 381 IGAGFVLNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGV 460
Cdd:cd17473 251 LLFGRLKRR--LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS--LVPPELRGRAMGI 326
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1907079528 461 YVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 508
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
330-533 |
4.61e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 4.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 330 FICYALFGLfaTLGFFAP--SLYIIPlgiSLGIDPDRAAFLLSTMAIAEV-----FGRIGagfvlNREPIRKIYIeLICV 402
Cdd:cd17471 2 LLATLLTGL--AGAFVLPylSLFLTE---ELGASPLQIGIFMTLSALSGIvvsqwLGRLS-----DRGGDRKPLI-LLAL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 403 ILLTASLFAFTFATEFWGLMLCSVFFGSmvgtIGGTHIPML------------AEDDVVGIEKMSSAAgvyvfiqSISGL 470
Cdd:cd17471 71 LAGALGYLLFAFLRNYWVLLLVGVVLLS----LGAAAFPQLfalareyadrssGRDATLFNSVLRAAF-------SLAWV 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079528 471 AGPPLAGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRPCKKGLCQNSHSGENQTDRQRGKAL 533
Cdd:cd17471 140 IGPPLAFLLLDVLG-FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRL 201
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
334-509 |
9.05e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 9.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 334 ALFGLFATLGFFAPSLYIIPLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFA 411
Cdd:cd17321 173 AVLAAFLLGAALGGLLFLLPLYLQgvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV--AGLLLTAVGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 412 FTFATE-------FWGLMLCSVFFGSMVGTIGGThipMLAeddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLV---- 480
Cdd:cd17321 251 LALLGAdssvwllLPGLVLLGLGLGLFATPLTNA---ALS---SVPKEKAGAASGILNTARQLGGALGVALLGALLtagl 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1907079528 481 --------------DQSKIYSRAF---YSCAAGMCLAAVCLALVRP 509
Cdd:cd17321 325 sanlgdsgvaallsAAAAAFAAGFhlaFLVAAALALLAALLALLLP 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
330-507 |
9.68e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.88 E-value: 9.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 330 FICYALFGLFATLGFFAPSlyiiplgiSLGIDPDRAAFLLSTMAIAEVFGRIG-AGFVLNREPIRKIYIelICVILLTAS 408
Cdd:cd17330 185 LIALAFAGLESVFSLFLKD--------RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLR--LGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 409 LFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLvdQSKIYSR 488
Cdd:cd17330 255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK--SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPG 330
|
170
....*....|....*....
gi 1907079528 489 AFYSCAAGMCLAAVCLALV 507
Cdd:cd17330 331 VPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
333-509 |
1.28e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 333 YALFGLFATLGFFAPSLYIIPLGISLgIDPDRAAFLLSTMAIAEVFGRIG----AGFVLNREPIRKIYI---ELICVILL 405
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLV-LQLTGSALLVGLVLAAFFLPFLLfspfAGVLADRFDRRRLLIladLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 406 TASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 485
Cdd:cd06173 80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPE--LVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157
|
170 180
....*....|....*....|....
gi 1907079528 486 YSrAFYSCAAGMCLAAVCLALVRP 509
Cdd:cd06173 158 GG-AFAINALSFLLSALLLLFIRR 180
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
336-509 |
1.42e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 336 FGLFATLGFFApsLYII-PLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASLFAFTF 414
Cdd:cd17329 13 LGFFMVWPFMA--IYLHqQLGLSASI----VGLVLALSAVAGIVASLIGGRLADRFGRKPVM--LAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 415 ATEFWGLMLCSV---FFGSMVGTIGGThipMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkiYSRAFY 491
Cdd:cd17329 85 AHSPWLFAIALVltgFGGGLFEPASEA---MIA--DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS--FRLLFL 157
|
170
....*....|....*...
gi 1907079528 492 SCAAGMCLAAVCLALVRP 509
Cdd:cd17329 158 AAAVLFLLAALVLLFLLP 175
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
336-517 |
1.72e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 336 FGLFATLGFFAP--SLYiiplGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyIELICVILLTASLFAFT 413
Cdd:cd17335 7 FFFFAALGSLLPflSVY----LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKA-LLLLSLLAAVLFFLSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 414 F-ATEFWGLML----CSVFFGSMVGTIGGTHIPMLAED-DVVGIEKMSSAAGvyvFIqsisglAGPPLAGLLVDQSKI-- 485
Cdd:cd17335 82 FvAQIFWLLLLlvilGAFFSAPVVPLVDSITLQYLGEErERYGKQRLWGSIG---FG------IAALLVGILIDRSSTyk 152
|
170 180 190
....*....|....*....|....*....|...
gi 1907079528 486 -YSRAFYSCAAGMCLAAVCLALVRPCKKGLCQN 517
Cdd:cd17335 153 nYTIAFYVFAVLMLLALLLALKFPFRPKHPEPN 185
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
328-502 |
1.78e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 328 KSFICYALFGLFATLGFFAPSLYIIPLGiSLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTA 407
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI--LGYLSLAL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 408 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYS 487
Cdd:cd17370 277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA--DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353
|
170
....*....|....*
gi 1907079528 488 RAFYSCAAGMCLAAV 502
Cdd:cd17370 354 AAFLFSAVLALIALL 368
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
307-479 |
4.07e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 307 VTAPKHSQMKAPLLD--FSVLKEKSFICYALFGLFATLGFFAP-SLYIIPLGISLGIDPDrAAFLLSTMAIAEVFGRIGA 383
Cdd:cd17332 198 VVPPEEEKSKLPLLKslKALLKNRPFLILLLAYLLYFLAFNIVnTVLVYYFKYVLGGRAE-LVLLLLLILSGALLALLPW 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 384 GFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS------- 456
Cdd:cd17332 277 PPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA--DVIDYGELKTgkrregi 354
|
170 180
....*....|....*....|...
gi 1907079528 457 AAGVYVFIQSISGLAGPPLAGLL 479
Cdd:cd17332 355 FYSVMTFFRKLGLALAGALVGLI 377
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
324-506 |
4.38e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 4.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 324 VLKEKSFICYAL---FGLFAT--LGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNRepIRKIYIE 398
Cdd:cd17328 203 LAKNPSFILSTLgftAVSFVTgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADR--LRRKTPR 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 399 ---LICVILLTASLFAFTFATEF--------WGLMLCSVFFGSMvgtiggTHIPMLAEDDVVGIEKM-SSAAGVYVFIQS 466
Cdd:cd17328 281 adpLVCAVGLLAAAPFLFLALVLalsnlllaWVLLFLGEFLLSL------NWAPVFAILLYVVIPTRrSTASAIQILLSH 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1907079528 467 ISGLAGPPLAG-----LLVDQSKIYSRAFYSCAAGMCLAAVCLAL 506
Cdd:cd17328 355 LLGDAGSPYLIglisdLLRQNKDSPLAEAASLQYALLLCSFVLVL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
357-507 |
2.79e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.33 E-value: 2.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079528 357 SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNRE-PIRKIYIELICVILLTASLFAFTFateFWGLMLCSVFFGSMVG-T 434
Cdd:cd17312 213 VKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWF---FPHNKLLSIVLLFLIGfF 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079528 435 IGGTH--IPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRAFYSCaAGMCLAAVCLALV 507
Cdd:cd17312 290 VGGPInlIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFL-ISAALLSVLLLLS 362
|
|
| |
