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Conserved domains on  [gi|1907074175|ref|XP_036011605|]
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melanocyte protein PMEL isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKAT_KLD pfam20433
PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, ...
 530-581 6.42e-19

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.


:

Pssm-ID: 466582  Cd Length: 51  Bit Score: 80.40  E-value: 6.42e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907074175 530 SCQGGLPKEACMDISSPGCQPPAQRLCQSVPPSPDCQLVLHQVLKgGSGTYC 581
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 283-349 2.80e-07

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


:

Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 48.15  E-value: 2.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907074175 283 NHPLIFALQLHDPSgylaeaDLSYTWDFGDGTGTlISRALDVTHTYLESGSVTAQVVLQAAIPLVSC 349
Cdd:pfam00801  11 GQPVTFTATLADGS------NVTYTWDFGDSPGT-SGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
304-478 5.01e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


:

Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 39.65  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175 304 LSYTWDFGDGTgtlISRALDVTHTYLESGSVTAQ------------------VVLQAAIPLVSCGSSPVPGTTDGYMPTA 365
Cdd:COG3291    25 TSYEWDFGDGT---TSTEANPSHTYTTPGTYTVTltvtdaagcsdtttktitVGAPNPGVTTVTTSTTVTTLANTANGGA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175 366 EAPGTTSRQGTTTKVVGTTPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPSGTTV 445
Cdd:COG3291   102 TTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTD 181

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907074175 446 AQATTTEGPDASPLLPTQSSTGSISPLLDDTDT 478
Cdd:COG3291   182 TVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGA 214
 
Name Accession Description Interval E-value
PKAT_KLD pfam20433
PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, ...
 530-581 6.42e-19

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.


Pssm-ID: 466582  Cd Length: 51  Bit Score: 80.40  E-value: 6.42e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907074175 530 SCQGGLPKEACMDISSPGCQPPAQRLCQSVPPSPDCQLVLHQVLKgGSGTYC 581
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 283-349 2.80e-07

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 48.15  E-value: 2.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907074175 283 NHPLIFALQLHDPSgylaeaDLSYTWDFGDGTGTlISRALDVTHTYLESGSVTAQVVLQAAIPLVSC 349
Cdd:pfam00801  11 GQPVTFTATLADGS------NVTYTWDFGDSPGT-SGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 288-343 8.14e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.11  E-value: 8.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907074175 288 FALQLHDPSGYlaeADLSYTWDFGDGTGTLiSRALDVTHTYLESGSVTAQVVLQAA 343
Cdd:cd00146    17 VTFSASDSSGG---SIVSYKWDFGDGEVSS-SGEPTVTHTYTKPGTYTVTLTVTNA 68
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 291-348 9.62e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 47.06  E-value: 9.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907074175  291 QLHDPSGYLAEaDLSYTWDFGDGTgtlISRALDVTHTYLESGSVTAQVVLQAAIPLVS 348
Cdd:smart00089  18 TFTATSSDDGS-IVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAVGSAS 71
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 245-333 3.32e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 3.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175  245 YVPLAHASSTF-TITDQVPFSVSvSQLQALDGETKH--FLRNHPLIF-ALQLHDPSGYLaeadlsYTWDFGDGTGTLISR 320
Cdd:TIGR00864 1062 YLATVLASNAFeNISQQINMSVR-AILPRVAIGTEDglLLAGKPADFeAHPLPSPGGIH------YEWDFGDGSALLQGR 1134

                           90
                   ....*....|...
gi 1907074175  321 ALDVTHTYLESGS 333
Cdd:TIGR00864 1135 QPAAAHTFAKRGP 1147
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
304-478 5.01e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 39.65  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175 304 LSYTWDFGDGTgtlISRALDVTHTYLESGSVTAQ------------------VVLQAAIPLVSCGSSPVPGTTDGYMPTA 365
Cdd:COG3291    25 TSYEWDFGDGT---TSTEANPSHTYTTPGTYTVTltvtdaagcsdtttktitVGAPNPGVTTVTTSTTVTTLANTANGGA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175 366 EAPGTTSRQGTTTKVVGTTPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPSGTTV 445
Cdd:COG3291   102 TTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTD 181

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907074175 446 AQATTTEGPDASPLLPTQSSTGSISPLLDDTDT 478
Cdd:COG3291   182 TVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGA 214
 
Name Accession Description Interval E-value
PKAT_KLD pfam20433
PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, ...
 530-581 6.42e-19

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.


Pssm-ID: 466582  Cd Length: 51  Bit Score: 80.40  E-value: 6.42e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907074175 530 SCQGGLPKEACMDISSPGCQPPAQRLCQSVPPSPDCQLVLHQVLKgGSGTYC 581
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 283-349 2.80e-07

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 48.15  E-value: 2.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907074175 283 NHPLIFALQLHDPSgylaeaDLSYTWDFGDGTGTlISRALDVTHTYLESGSVTAQVVLQAAIPLVSC 349
Cdd:pfam00801  11 GQPVTFTATLADGS------NVTYTWDFGDSPGT-SGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 288-343 8.14e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.11  E-value: 8.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907074175 288 FALQLHDPSGYlaeADLSYTWDFGDGTGTLiSRALDVTHTYLESGSVTAQVVLQAA 343
Cdd:cd00146    17 VTFSASDSSGG---SIVSYKWDFGDGEVSS-SGEPTVTHTYTKPGTYTVTLTVTNA 68
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 291-348 9.62e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 47.06  E-value: 9.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907074175  291 QLHDPSGYLAEaDLSYTWDFGDGTgtlISRALDVTHTYLESGSVTAQVVLQAAIPLVS 348
Cdd:smart00089  18 TFTATSSDDGS-IVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAVGSAS 71
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 304-339 2.45e-04

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 40.33  E-value: 2.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907074175 304 LSYTWDFGDGTgtlISRALDVTHTYLESGSVTAQVV 339
Cdd:pfam18911  35 LSYRWDFGDGT---TATGANVSHTYAAPGTYTVTLT 67
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 245-333 3.32e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 3.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175  245 YVPLAHASSTF-TITDQVPFSVSvSQLQALDGETKH--FLRNHPLIF-ALQLHDPSGYLaeadlsYTWDFGDGTGTLISR 320
Cdd:TIGR00864 1062 YLATVLASNAFeNISQQINMSVR-AILPRVAIGTEDglLLAGKPADFeAHPLPSPGGIH------YEWDFGDGSALLQGR 1134

                           90
                   ....*....|...
gi 1907074175  321 ALDVTHTYLESGS 333
Cdd:TIGR00864 1135 QPAAAHTFAKRGP 1147
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
304-478 5.01e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 39.65  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175 304 LSYTWDFGDGTgtlISRALDVTHTYLESGSVTAQ------------------VVLQAAIPLVSCGSSPVPGTTDGYMPTA 365
Cdd:COG3291    25 TSYEWDFGDGT---TSTEANPSHTYTTPGTYTVTltvtdaagcsdtttktitVGAPNPGVTTVTTSTTVTTLANTANGGA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074175 366 EAPGTTSRQGTTTKVVGTTPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPSGTTV 445
Cdd:COG3291   102 TTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTD 181

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907074175 446 AQATTTEGPDASPLLPTQSSTGSISPLLDDTDT 478
Cdd:COG3291   182 TVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGA 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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