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Conserved domains on  [gi|1907073828|ref|XP_036011566|]
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protein NEDD1 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-338 8.35e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 8.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  63 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLnSTSMYLASGGLNNTVNI 142
Cdd:cd00200     1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 143 WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF-GHgsKQPIRHIKYSLFRKSLLGSvS 221
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 222 DNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 300
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1907073828 301 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 338
Cdd:cd00200   233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-338 8.35e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 8.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  63 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLnSTSMYLASGGLNNTVNI 142
Cdd:cd00200     1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 143 WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF-GHgsKQPIRHIKYSLFRKSLLGSvS 221
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 222 DNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 300
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1907073828 301 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 338
Cdd:cd00200   233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
6-338 5.90e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 5.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828   6 SGRPSLTVQAGAGSAARNGWSWASPVAPRLRGPVMQENLRFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSS 83
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgtVRLWDLATGLLLRTLTGHTGA--VRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  84 NNNFLVTASSsgDKIVVssckckpvpLLELAEGQKQ----------TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRS 153
Cdd:COG2319   131 DGKTLASGSA--DGTVR---------LWDLATGKLLrtltghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 154 LKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSkQPIRHIKYSLFRKSLLgSVSDNGVVTLWDVNS 233
Cdd:COG2319   200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSPDGRLLA-SGSADGTVRLWDLAT 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 234 QSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIY 312
Cdd:COG2319   278 GELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVR 355

                         330       340
                  ....*....|....*....|....*.
gi 1907073828 313 QYDLRMLKsPVKTISAHKTSVQCIAF 338
Cdd:COG2319   356 LWDLATGE-LLRTLTGHTGAVTSVAF 380
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 199-348 1.25e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.17  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 199 GSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVnSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSK 278
Cdd:PLN00181  530 ASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907073828 279 KLVKTLVADTPLTAVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKAS 348
Cdd:PLN00181  609 VSIGTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-186 4.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907073828  147 SKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHS 186
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-338 8.35e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 8.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  63 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLnSTSMYLASGGLNNTVNI 142
Cdd:cd00200     1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 143 WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF-GHgsKQPIRHIKYSLFRKSLLGSvS 221
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 222 DNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 300
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1907073828 301 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 338
Cdd:cd00200   233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
6-338 5.90e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 5.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828   6 SGRPSLTVQAGAGSAARNGWSWASPVAPRLRGPVMQENLRFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSS 83
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgtVRLWDLATGLLLRTLTGHTGA--VRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  84 NNNFLVTASSsgDKIVVssckckpvpLLELAEGQKQ----------TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRS 153
Cdd:COG2319   131 DGKTLASGSA--DGTVR---------LWDLATGKLLrtltghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 154 LKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSkQPIRHIKYSLFRKSLLgSVSDNGVVTLWDVNS 233
Cdd:COG2319   200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSPDGRLLA-SGSADGTVRLWDLAT 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 234 QSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIY 312
Cdd:COG2319   278 GELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVR 355

                         330       340
                  ....*....|....*....|....*.
gi 1907073828 313 QYDLRMLKsPVKTISAHKTSVQCIAF 338
Cdd:COG2319   356 LWDLATGE-LLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
45-317 1.26e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  45 RFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIV----VSSCKCkpvpLLELAEGQK 118
Cdd:COG2319   134 TLASGSADgtVRLWDLATGKLLRTLTGHSGA--VTSVAFSPDGKLLASGSD--DGTVrlwdLATGKL----LRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 119 Q-TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFG 197
Cdd:COG2319   206 AvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 198 HGSkQPIRHIKYSLFRKSLLgSVSDNGVVTLWDVNSQSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILYDTSS 277
Cdd:COG2319   286 GHS-GGVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1907073828 278 KKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLR 317
Cdd:COG2319   362 GELLRTLTGHTgAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
131-338 1.40e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 131 LASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFgHGSKQPIRHIKYS 210
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 211 LFRKSLLgSVSDNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT-P 289
Cdd:COG2319   130 PDGKTLA-SGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTgA 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1907073828 290 LTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 338
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF 254
WD40 COG2319
WD40 repeat [General function prediction only];
45-233 8.62e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 8.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  45 RFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLvtASSSGDKIV----VSSCKCkpvplLELAEGQK 118
Cdd:COG2319   218 LLASGSADgtVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL--ASGSADGTVrlwdLATGEL-----LRTLTGHS 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 119 Q--TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF 196
Cdd:COG2319   289 GgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907073828 197 -GHGSkqPIRHIKYSLfRKSLLGSVSDNGVVTLWDVNS 233
Cdd:COG2319   369 tGHTG--AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-184 1.65e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  47 ASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIV--VSSCKCkpvplLELAEGQKQ--T 120
Cdd:cd00200   151 ASSSQDgtIKLWDLRTGKCVATLTGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLwdLSTGKC-----LGTLRGHENgvN 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907073828 121 CVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIIL 184
Cdd:cd00200   224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 199-348 1.25e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.17  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 199 GSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVnSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSK 278
Cdd:PLN00181  530 ASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907073828 279 KLVKTLVADTPLTAVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKAS 348
Cdd:PLN00181  609 VSIGTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 43-144 6.56e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 6.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828  43 NLRFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGdKIVV-SSCKCKPVplLELAEGQKQ 119
Cdd:cd00200   189 GEKLLSSSSDgtIKLWDLSTGKCLGTLRGHENG--VNSVAFSPDGYLLASGSEDG-TIRVwDLRTGECV--QTLSGHTNS 263

                          90       100
                  ....*....|....*....|....*.
gi 1907073828 120 -TCVDLNSTSMYLASGGLNNTVNIWD 144
Cdd:cd00200   264 vTSLAWSPDGKRLASGSADGTIRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
164-327 7.73e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 7.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 164 VAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDST 243
Cdd:COG3391    30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073828 244 HKApaSGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGK-----IYQYDLRM 318
Cdd:COG3391   110 GGP--RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187


                  ....*....
gi 1907073828 319 LKsPVKTIS 327
Cdd:COG3391   188 GK-VVATIP 195
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-186 4.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907073828  147 SKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHS 186
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 249-318 1.24e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.44  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907073828 249 SGICF-SPVNELLFVTIGLDKRIILYDTSSKK--LVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRM 318
Cdd:cd22857   182 TDLTFlSKDDHRKIVTGTGYHQVRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRT 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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