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Conserved domains on  [gi|1907195729|ref|XP_036010617|]
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roundabout homolog 3 isoform X6 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 51-136 9.00e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 9.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  51 VTEVTANSITLTWKPNPQSGATATSYVIEaFSQAAGNTWRTVADGVQLET-YTISGLQPNTIYLFLVRAVGAWGLSEPSP 129
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEDDGGPITGYVVE-YREKGSGDWKEVEVTPGSETsYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*..
gi 1907195729 130 vSEPVQT 136
Cdd:cd00063    88 -SVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 257-350 9.64e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 9.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 257 GPPQGVAVALGGDrnSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 335
Cdd:cd00063     2 SPPTNLRVTDVTS--TSVTLSWTPPEDD--GGPITGYVVeYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*
gi 1907195729 336 TSAGVGVASAPVLVQ 350
Cdd:cd00063    78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 164-247 3.63e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 164 EPTVLGPRTLQVSWT-VDGPVQLVQGFRVSWRIAglDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAE 242
Cdd:cd00063     8 RVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREK--GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*
gi 1907195729 243 SPFVT 247
Cdd:cd00063    86 SESVT 90
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 51-136 9.00e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 9.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  51 VTEVTANSITLTWKPNPQSGATATSYVIEaFSQAAGNTWRTVADGVQLET-YTISGLQPNTIYLFLVRAVGAWGLSEPSP 129
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEDDGGPITGYVVE-YREKGSGDWKEVEVTPGSETsYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*..
gi 1907195729 130 vSEPVQT 136
Cdd:cd00063    88 -SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
51-128 8.16e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 8.16e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907195729  51 VTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPS 128
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 51-125 2.35e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 2.35e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907195729   51 VTEVTANSITLTWKPNPQSGATA--TSYVIEafSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLS 125
Cdd:smart00060   9 VTDVTSTSVTLSWEPPPDDGITGyiVGYRVE--YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 257-350 9.64e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 9.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 257 GPPQGVAVALGGDrnSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 335
Cdd:cd00063     2 SPPTNLRVTDVTS--TSVTLSWTPPEDD--GGPITGYVVeYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*
gi 1907195729 336 TSAGVGVASAPVLVQ 350
Cdd:cd00063    78 NGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
257-344 1.39e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 257 GPPQGVAVAlgGDRNSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 335
Cdd:pfam00041   1 SAPSNLTVT--DVTSTSLTVSWTPPPDG--NGPITGYEVeYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 1907195729 336 TSAGVGVAS 344
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 257-341 1.61e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  257 GPPQGVAVALGGDrnSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHlNRSAAGWARSVTFSGLLPGQIYRALVAAAT 336
Cdd:smart00060   2 SPPSNLRVTDVTS--TSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....*
gi 1907195729  337 SAGVG 341
Cdd:smart00060  79 GAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
51-296 2.07e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  51 VTEVTANSITLTWKPNPQSGatATSYVIEAfSQAAGNTWRTVADgVQLETYTISGLQPNTIYLFLVRAVGAWGL-SEPSP 129
Cdd:COG3401   241 ATADTPGSVTLSWDPVTESD--ATGYRVYR-SNSGDGPFTKVAT-VTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSN 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 130 VSEpVQTQDSSLSRPAedpwkgqrGLAEvavrmqepTVLGPRTLQVSWT-VDGPvqLVQGFRVsWRIAGLDqGSWTMLDl 208
Cdd:COG3401   317 VVS-VTTDLTPPAAPS--------GLTA--------TAVGSSSITLSWTaSSDA--DVTGYNV-YRSTSGG-GTYTKIA- 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 209 QSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPP---QGVAVALGGDRNSSVTVSWEPPLPSQ 285
Cdd:COG3401   375 ETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESltaSVDAVPLTDVAGATAAASAASNPGVS 454

                         250
                  ....*....|.
gi 1907195729 286 RNGVITEYQIW 296
Cdd:COG3401   455 AAVLADGGDTG 465
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 164-247 3.63e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 164 EPTVLGPRTLQVSWT-VDGPVQLVQGFRVSWRIAglDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAE 242
Cdd:cd00063     8 RVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREK--GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*
gi 1907195729 243 SPFVT 247
Cdd:cd00063    86 SESVT 90
fn3 pfam00041
Fibronectin type III domain;
166-243 1.96e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 166 TVLGPRTLQVSWT----VDGPVQlvqGFRVSWRIAGlDQGSWTMLDLqSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGA 241
Cdd:pfam00041   9 TDVTSTSLTVSWTpppdGNGPIT---GYEVEYRPKN-SGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                  ..
gi 1907195729 242 ES 243
Cdd:pfam00041  84 PS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 51-136 9.00e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 9.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  51 VTEVTANSITLTWKPNPQSGATATSYVIEaFSQAAGNTWRTVADGVQLET-YTISGLQPNTIYLFLVRAVGAWGLSEPSP 129
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEDDGGPITGYVVE-YREKGSGDWKEVEVTPGSETsYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*..
gi 1907195729 130 vSEPVQT 136
Cdd:cd00063    88 -SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
51-128 8.16e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 8.16e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907195729  51 VTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPS 128
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 51-125 2.35e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 2.35e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907195729   51 VTEVTANSITLTWKPNPQSGATA--TSYVIEafSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLS 125
Cdd:smart00060   9 VTDVTSTSVTLSWEPPPDDGITGyiVGYRVE--YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 257-350 9.64e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 9.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 257 GPPQGVAVALGGDrnSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 335
Cdd:cd00063     2 SPPTNLRVTDVTS--TSVTLSWTPPEDD--GGPITGYVVeYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*
gi 1907195729 336 TSAGVGVASAPVLVQ 350
Cdd:cd00063    78 NGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
257-344 1.39e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 257 GPPQGVAVAlgGDRNSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 335
Cdd:pfam00041   1 SAPSNLTVT--DVTSTSLTVSWTPPPDG--NGPITGYEVeYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 1907195729 336 TSAGVGVAS 344
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 257-341 1.61e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  257 GPPQGVAVALGGDrnSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHlNRSAAGWARSVTFSGLLPGQIYRALVAAAT 336
Cdd:smart00060   2 SPPSNLRVTDVTS--TSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....*
gi 1907195729  337 SAGVG 341
Cdd:smart00060  79 GAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
51-296 2.07e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  51 VTEVTANSITLTWKPNPQSGatATSYVIEAfSQAAGNTWRTVADgVQLETYTISGLQPNTIYLFLVRAVGAWGL-SEPSP 129
Cdd:COG3401   241 ATADTPGSVTLSWDPVTESD--ATGYRVYR-SNSGDGPFTKVAT-VTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSN 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 130 VSEpVQTQDSSLSRPAedpwkgqrGLAEvavrmqepTVLGPRTLQVSWT-VDGPvqLVQGFRVsWRIAGLDqGSWTMLDl 208
Cdd:COG3401   317 VVS-VTTDLTPPAAPS--------GLTA--------TAVGSSSITLSWTaSSDA--DVTGYNV-YRSTSGG-GTYTKIA- 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 209 QSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPP---QGVAVALGGDRNSSVTVSWEPPLPSQ 285
Cdd:COG3401   375 ETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESltaSVDAVPLTDVAGATAAASAASNPGVS 454

                         250
                  ....*....|.
gi 1907195729 286 RNGVITEYQIW 296
Cdd:COG3401   455 AAVLADGGDTG 465
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
54-364 5.33e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.55  E-value: 5.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  54 VTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPSPVSEP 133
Cdd:COG3401   147 LYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 134 VQtqdssLSRPAEDPwkgqrglAEVAVrmqepTVLGPRTLQVSWTvDGPVQLVQGFRVSWRIAGldQGSWTMLDlqSPHK 213
Cdd:COG3401   227 TT-----PTTPPSAP-------TGLTA-----TADTPGSVTLSWD-PVTESDATGYRVYRSNSG--DGPFTKVA--TVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 214 QSTVLRGLPPGAQIQIKVQVQGQEGL-GAESPFVTRSIPEEAPSgPPQGVAVALGGdrNSSVTVSWEPPLpsqrNGVITE 292
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASS----DADVTG 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 293 YQIWclgnesrfhlnRSAAG---WAR--------SVTFSGLLPGQIYRALVAAATSAG----------VGVASAPVLVQL 351
Cdd:COG3401   358 YNVY-----------RSTSGggtYTKiaetvtttSYTDTGLTPGTTYYYKVTAVDAAGnesapseevsATTASAASGESL 426

                         330
                  ....*....|...
gi 1907195729 352 PFPPAAEPGPEVS 364
Cdd:COG3401   427 TASVDAVPLTDVA 439
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 164-247 3.63e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 164 EPTVLGPRTLQVSWT-VDGPVQLVQGFRVSWRIAglDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAE 242
Cdd:cd00063     8 RVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREK--GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*
gi 1907195729 243 SPFVT 247
Cdd:cd00063    86 SESVT 90
fn3 pfam00041
Fibronectin type III domain;
166-243 1.96e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 166 TVLGPRTLQVSWT----VDGPVQlvqGFRVSWRIAGlDQGSWTMLDLqSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGA 241
Cdd:pfam00041   9 TDVTSTSLTVSWTpppdGNGPIT---GYEVEYRPKN-SGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                  ..
gi 1907195729 242 ES 243
Cdd:pfam00041  84 PS 85
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
51-349 3.24e-05

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 47.07  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729  51 VTEVTANSITLTWkpnpqSGATATSYVIEAFSQAAGNTWRTVADGVqleTYTISGLQPNTIYLFLVRAVGAWG-LSEPSP 129
Cdd:COG3979    11 ASNVTSSSVSLSW-----DASTDNVGVTGYDVYRGGDQVATVTGLT---AWTVTGLTPGTEYTFTVGACDAAGnVSAASG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 130 VSEPVQTQDSSLSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTLQVSWTVDGPVQLVQGFRVSWRIAGLDQGSWTMLDLQ 209
Cdd:COG3979    83 TSTAMFGGSSTTLGSAEGVADTSGNLAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGGTTTIITTGVEGG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195729 210 --SPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPPQGVAVALGGDRNSSVTVSWEPPLPSQRN 287
Cdd:COG3979   163 ggSKTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSGTTATGGTVGITSAYG 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907195729 288 GVITEYQIWCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAATSAGVGVASAPVLV 349
Cdd:COG3979   243 AGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGG 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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