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Conserved domains on  [gi|1907195054|ref|XP_036010512|]
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interleukin-18 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 25-170 5.27e-52

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466780  Cd Length: 149  Bit Score: 163.15  E-value: 5.27e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  25 HCTTAVIRNINDQVLFVDKR-QPVFEDMTDIDQSasEPQTRLIIYMYKDSEV-RGLAVTLSV-KDSKMSTLSCK-NKIIS 100
Cdd:cd23298     1 KSKTSIIRNKDNKFLVLDPDgQFVFEDLTDQELN--APDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907195054 101 FEEMDPPENIDDIQSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTL 170
Cdd:cd23298    79 FKEMDLPDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
 
Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 25-170 5.27e-52

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 163.15  E-value: 5.27e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  25 HCTTAVIRNINDQVLFVDKR-QPVFEDMTDIDQSasEPQTRLIIYMYKDSEV-RGLAVTLSV-KDSKMSTLSCK-NKIIS 100
Cdd:cd23298     1 KSKTSIIRNKDNKFLVLDPDgQFVFEDLTDQELN--APDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907195054 101 FEEMDPPENIDDIQSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTL 170
Cdd:cd23298    79 FKEMDLPDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 60-166 4.64e-26

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 95.98  E-value: 4.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  60 EPQTRLIIYMYK-DSEVRGLAVTLSVKDSKMsTLSCKNK---IISFEEMDPPENIDDIQSDLIF-FQKRVPGHNkMEFES 134
Cdd:pfam00340   7 NLEVKFDMSFYKgDSDDSKIPVTLGIKGKKL-YLSCVNKdepVLQLEEVNIPKLIKNKESDKRFfFIRSESKNY-VEFES 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907195054 135 SLYEGHFLACQKEDDAFKLILK---KKDENGDKSV 166
Cdd:pfam00340  85 AAYPGWFIATKQEEDLPVFLVNtagGQDSITDFQI 119
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 78-149 1.33e-04

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 40.06  E-value: 1.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907195054   78 LAVTLSVKDSKMsTLSCKNK----IISFEEMDPPENIDDiQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDD 149
Cdd:smart00125  54 IPVTLGISGTNL-YLSCVKKgdepTLQLEMVDPPKYPKK-EMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEED 127
 
Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 25-170 5.27e-52

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 163.15  E-value: 5.27e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  25 HCTTAVIRNINDQVLFVDKR-QPVFEDMTDIDQSasEPQTRLIIYMYKDSEV-RGLAVTLSV-KDSKMSTLSCK-NKIIS 100
Cdd:cd23298     1 KSKTSIIRNKDNKFLVLDPDgQFVFEDLTDQELN--APDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907195054 101 FEEMDPPENIDDIQSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTL 170
Cdd:cd23298    79 FKEMDLPDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 60-166 4.64e-26

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 95.98  E-value: 4.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  60 EPQTRLIIYMYK-DSEVRGLAVTLSVKDSKMsTLSCKNK---IISFEEMDPPENIDDIQSDLIF-FQKRVPGHNkMEFES 134
Cdd:pfam00340   7 NLEVKFDMSFYKgDSDDSKIPVTLGIKGKKL-YLSCVNKdepVLQLEEVNIPKLIKNKESDKRFfFIRSESKNY-VEFES 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907195054 135 SLYEGHFLACQKEDDAFKLILK---KKDENGDKSV 166
Cdd:pfam00340  85 AAYPGWFIATKQEEDLPVFLVNtagGQDSITDFQI 119
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 28-170 2.41e-19

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 79.29  E-value: 2.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  28 TAVIRNINDQVLFVD-KRQPVFEDMTDIDQSASepqtrLIIYMYKDSEV---RGLAVTLSVKDsKMSTLSC----KNKII 99
Cdd:cd00100     4 NFVIRDSNDKSLYLRgNNELVAEDLSDVEKSAK-----ITIYYYKSDSDedfKGIPVVLNFTG-TNCFLSCvkegDKPSL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907195054 100 SFEEMDPPE--NIDDIQSDLIFFQKRVPGhNKMEFESSLYEGHFLACQKEDdafKLILKKKDENgDKSVMFTL 170
Cdd:cd00100    78 QLEECNKEElkNGDEEEWPFVFYMKASHD-NTCRFESAAHPGWFICTKKDQ---PVGLTKELGK-TEDTDFYF 145
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 67-149 5.08e-05

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466777  Cd Length: 145  Bit Score: 41.17  E-value: 5.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  67 IYMYKDSE-VRGLAVTLSVKDSKMSTLSCK-NKIISFEEMDP-PENIDDIQSDLIFFQKRvpgHNKMEFESSLYEGHFLA 143
Cdd:cd23295    46 IGAYKSLDdDYKIPVTLRISNTQLFVSAQGeDEPVLLKEMPEtPKTITGSETNLLFFWEE---HGTKNFFSSAANPELFA 122


                  ....*.
gi 1907195054 144 CQKEDD 149
Cdd:cd23295   123 ATKQDE 128
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 78-149 1.33e-04

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 40.06  E-value: 1.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907195054   78 LAVTLSVKDSKMsTLSCKNK----IISFEEMDPPENIDDiQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDD 149
Cdd:smart00125  54 IPVTLGISGTNL-YLSCVKKgdepTLQLEMVDPPKYPKK-EMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEED 127
beta-trefoil_IL1B cd23296
beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, ...
 68-149 5.69e-03

beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, also called catabolin, is a potent inflammatory cytokine that activates the inflammatory process. It was initially discovered as the major endogenous pyrogen. It induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. IL-1 beta promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFN-gamma synthesis from T-helper 1 (Th1) cells. It plays a role in angiogenesis by inducing vascular endothelial growth factor (VEGF) production synergistically with tumor necrosis factor (TNF) and IL-6. IL-1 beta contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466778  Cd Length: 150  Bit Score: 35.67  E-value: 5.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195054  68 YMYKDSEVRGLAVTLSVKDSKMsTLSC----KNKIISFEEMDPPENIDdiQSDL---IFFqKRVPGHNKMEFESSLYEGH 140
Cdd:cd23296    46 YRSPESNGGKIPVALGIKGKNL-YLSCvkkgDKPTLQLEEVDPKNDSK--SKDLkrfLFY-KIESIGSTTTFESAAFPGW 121


                  ....*....
gi 1907195054 141 FLACQKEDD 149
Cdd:cd23296   122 YISTSQAEN 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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