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Conserved domains on  [gi|1907194709|ref|XP_036010467|]
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serine-protein kinase ATM isoform X2 [Mus musculus]

Protein Classification

TAN domain-containing protein( domain architecture ID 10569357)

TAN domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAN pfam11640
Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, ...
 8-165 5.34e-20

Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.


:

Pssm-ID: 463317  Cd Length: 150  Bit Score: 88.53  E-value: 5.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194709    8 LLICCRQLEHDRATERRKEVDKFKRLIQDPETVQhlDRHSDSKQgkylnWDAVFRFLQKYIQKEMESLRTAKSnvSATTQ 87
Cdd:pfam11640    1 LLEILSLLSSSKIKERNDALEDLKHILSSNRNKS--LSALNDKA-----WHSIFEALFRLIEAEKSAYLKAKK--SSTSK 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194709   88 SSRQKKMQEISSLVRYFIKCANKrapRLKcQDLLNYVMDTVKDSSNGLT------YGADCSNIlLKDILSVRKYWCEVSQ 161
Cdd:pfam11640   72 SAAARRLSSAASALRLVVEKAVS---RLK-RKTLKALLDHITQLLPLPDgellepLALDYSKA-LRSLLSYRPHVEHLDA 146


                   ....
gi 1907194709  162 QQWL 165
Cdd:pfam11640  147 EDWI 150
FAT super family cl26693
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
 2116-2174 1.17e-07

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


The actual alignment was detected with superfamily member pfam02259:

Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 56.21  E-value: 1.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907194709 2116 QELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFYeslRYASLFR 2174
Cdd:pfam02259    1 APLAAEAAWRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAE---RYIEKAR 56
 
Name Accession Description Interval E-value
TAN pfam11640
Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, ...
 8-165 5.34e-20

Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.


Pssm-ID: 463317  Cd Length: 150  Bit Score: 88.53  E-value: 5.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194709    8 LLICCRQLEHDRATERRKEVDKFKRLIQDPETVQhlDRHSDSKQgkylnWDAVFRFLQKYIQKEMESLRTAKSnvSATTQ 87
Cdd:pfam11640    1 LLEILSLLSSSKIKERNDALEDLKHILSSNRNKS--LSALNDKA-----WHSIFEALFRLIEAEKSAYLKAKK--SSTSK 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194709   88 SSRQKKMQEISSLVRYFIKCANKrapRLKcQDLLNYVMDTVKDSSNGLT------YGADCSNIlLKDILSVRKYWCEVSQ 161
Cdd:pfam11640   72 SAAARRLSSAASALRLVVEKAVS---RLK-RKTLKALLDHITQLLPLPDgellepLALDYSKA-LRSLLSYRPHVEHLDA 146


                   ....
gi 1907194709  162 QQWL 165
Cdd:pfam11640  147 EDWI 150
FAT pfam02259
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
 2116-2174 1.17e-07

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 56.21  E-value: 1.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907194709 2116 QELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFYeslRYASLFR 2174
Cdd:pfam02259    1 APLAAEAAWRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAE---RYIEKAR 56
 
Name Accession Description Interval E-value
TAN pfam11640
Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, ...
 8-165 5.34e-20

Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.


Pssm-ID: 463317  Cd Length: 150  Bit Score: 88.53  E-value: 5.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194709    8 LLICCRQLEHDRATERRKEVDKFKRLIQDPETVQhlDRHSDSKQgkylnWDAVFRFLQKYIQKEMESLRTAKSnvSATTQ 87
Cdd:pfam11640    1 LLEILSLLSSSKIKERNDALEDLKHILSSNRNKS--LSALNDKA-----WHSIFEALFRLIEAEKSAYLKAKK--SSTSK 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194709   88 SSRQKKMQEISSLVRYFIKCANKrapRLKcQDLLNYVMDTVKDSSNGLT------YGADCSNIlLKDILSVRKYWCEVSQ 161
Cdd:pfam11640   72 SAAARRLSSAASALRLVVEKAVS---RLK-RKTLKALLDHITQLLPLPDgellepLALDYSKA-LRSLLSYRPHVEHLDA 146


                   ....
gi 1907194709  162 QQWL 165
Cdd:pfam11640  147 EDWI 150
FAT pfam02259
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
 2116-2174 1.17e-07

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 56.21  E-value: 1.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907194709 2116 QELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFYeslRYASLFR 2174
Cdd:pfam02259    1 APLAAEAAWRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAE---RYIEKAR 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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