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Conserved domains on  [gi|1907070451|ref|XP_036009664|]
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testis-expressed protein 35 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tsc35 super family cl20949
Testis-specific protein 35; Tsc35 (also referred to in the literature as Tsc24) is essential ...
1-154 3.47e-86

Testis-specific protein 35; Tsc35 (also referred to in the literature as Tsc24) is essential for spermatogenesis in mammalian male reproduction. It is expressed in the testis from day 35 onwards in mice.


The actual alignment was detected with superfamily member pfam15079:

Pssm-ID: 464490  Cd Length: 205  Bit Score: 252.46  E-value: 3.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070451   1 MEPKLTQIYDFKGFKQEGLLIRKGMTRELKNELREVREQLTEKMEEIKQIKDIMDKDFDKLYEFVEIMKEMQQDMDEKMD 80
Cdd:pfam15079  24 LKPEPTKTYDYKGVKQEGPFTKTGGTQELKNELREVREELKEKMEEIKQIKDIMDKDFDKLHEFVEIMKEMQKDMDEKMD 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070451  81 VLINNQKNNKLPFQNQAKEQQKFWQLGKMDKGSQAMITEEP--DGAPLACD-KNVVPPKPTRNPLESLHPCQSCCQE 154
Cdd:pfam15079 104 VLINIQKNNKLPLRRGPKEQQELRLMGKTDTDPQLRLKKMDgaDGAPLALHkKMMAPQKPKKDPLDSLHQCRTCCEK 180
 
Name Accession Description Interval E-value
Tsc35 pfam15079
Testis-specific protein 35; Tsc35 (also referred to in the literature as Tsc24) is essential ...
1-154 3.47e-86

Testis-specific protein 35; Tsc35 (also referred to in the literature as Tsc24) is essential for spermatogenesis in mammalian male reproduction. It is expressed in the testis from day 35 onwards in mice.


Pssm-ID: 464490  Cd Length: 205  Bit Score: 252.46  E-value: 3.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070451   1 MEPKLTQIYDFKGFKQEGLLIRKGMTRELKNELREVREQLTEKMEEIKQIKDIMDKDFDKLYEFVEIMKEMQQDMDEKMD 80
Cdd:pfam15079  24 LKPEPTKTYDYKGVKQEGPFTKTGGTQELKNELREVREELKEKMEEIKQIKDIMDKDFDKLHEFVEIMKEMQKDMDEKMD 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070451  81 VLINNQKNNKLPFQNQAKEQQKFWQLGKMDKGSQAMITEEP--DGAPLACD-KNVVPPKPTRNPLESLHPCQSCCQE 154
Cdd:pfam15079 104 VLINIQKNNKLPLRRGPKEQQELRLMGKTDTDPQLRLKKMDgaDGAPLALHkKMMAPQKPKKDPLDSLHQCRTCCEK 180
 
Name Accession Description Interval E-value
Tsc35 pfam15079
Testis-specific protein 35; Tsc35 (also referred to in the literature as Tsc24) is essential ...
1-154 3.47e-86

Testis-specific protein 35; Tsc35 (also referred to in the literature as Tsc24) is essential for spermatogenesis in mammalian male reproduction. It is expressed in the testis from day 35 onwards in mice.


Pssm-ID: 464490  Cd Length: 205  Bit Score: 252.46  E-value: 3.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070451   1 MEPKLTQIYDFKGFKQEGLLIRKGMTRELKNELREVREQLTEKMEEIKQIKDIMDKDFDKLYEFVEIMKEMQQDMDEKMD 80
Cdd:pfam15079  24 LKPEPTKTYDYKGVKQEGPFTKTGGTQELKNELREVREELKEKMEEIKQIKDIMDKDFDKLHEFVEIMKEMQKDMDEKMD 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070451  81 VLINNQKNNKLPFQNQAKEQQKFWQLGKMDKGSQAMITEEP--DGAPLACD-KNVVPPKPTRNPLESLHPCQSCCQE 154
Cdd:pfam15079 104 VLINIQKNNKLPLRRGPKEQQELRLMGKTDTDPQLRLKKMDgaDGAPLALHkKMMAPQKPKKDPLDSLHQCRTCCEK 180
Nup88 pfam10168
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...
27-114 5.37e-03

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.


Pssm-ID: 462975 [Multi-domain]  Cd Length: 713  Bit Score: 36.95  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070451  27 RELKNELREVREQLTEKMEEIK--------QIKDIMDKDFDKLYEFVEIMKEMQQD---MDEKMDVLinnqkNNKLpfqN 95
Cdd:pfam10168 581 EEERKSLSERAEKLAEKYEEIKdkqeklmrRCKKVLQRLNSQLPVLSDAEREMKKEletINEQLKHL-----ANAI---K 652
                          90
                  ....*....|....*....
gi 1907070451  96 QAKEQQKFwQLGKMDKGSQ 114
Cdd:pfam10168 653 QAKKKMNY-QRYQIAKSQS 670
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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