|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
154-483 |
6.15e-148 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 464.83 E-value: 6.15e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 154 SLT-RRRDAERRYTSSSADSEEGKGP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGTNFTLRELGLGEM 231
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 232 TPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETD--- 308
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNeng 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 309 ---HPSS----------------------------------------------------------------LQNHPRLRT 321
Cdd:pfam06484 161 ppiPPSSsssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppnFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 322 PPPPLPHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPagSAQEPTHAQDNWLLNSNIPLETRnlgkqpfl 401
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQ--STQESVQLQDSWVLNSNVPLETR-------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 402 gtlqdnliemdilsasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFSRPAFNLKKPSKYC 480
Cdd:pfam06484 310 -------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYC 364
|
...
gi 1907180936 481 NWK 483
Cdd:pfam06484 365 SWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1367-1708 |
4.16e-47 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 173.10 E-value: 4.16e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1367 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYY----LATDPmSGA 1436
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1437 VFLSDTNSRRVFKVKSTTVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1514
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1515 RRVDQNGIISTLLGsndlTSARPLSCDSVMeiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1592
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1593 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1672
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 1907180936 1673 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1708
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2830-2907 |
3.30e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.43 E-value: 3.30e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180936 2830 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 2907
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1741-2606 |
1.12e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.97 E-value: 1.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1741 LYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALRSVTTQGHELAMMTY 1820
Cdd:COG3209 191 LATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGAS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1821 HGNSGLLATKSNENGW--TTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQ 1898
Cdd:COG3209 271 GAGLDASTGTGGAGGSnaAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1899 DQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRV 1978
Cdd:COG3209 351 GGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGG 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1979 HNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRI 2058
Cdd:COG3209 431 TATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTT 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2059 TSRIFADgkmWSYTYLEKSMVLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFT 2138
Cdd:COG3209 511 TTTAGAR---GLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGG 587
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2139 EDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTVNLQNEGFTCTIRYRQIGPLIDRQIFRFTE 2218
Cdd:COG3209 588 TATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGT 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2219 EGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKE 2298
Cdd:COG3209 668 GVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2299 VQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSAR 2378
Cdd:COG3209 747 TSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGG 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2379 LTPL-----RYDLRDRITRLgdvqykmdEDGFLRQRGGDVFEYNSAGLLIKAynRASGWSVRYRYDGLGRRVSSKSSHSH 2453
Cdd:COG3209 826 GTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSA--TDPGTTESYTYDANGNLTSRTDGGTT 895
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2454 HLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYTAYGEI 2533
Cdd:COG3209 896 TYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNL 954
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180936 2534 YMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 2606
Cdd:COG3209 955 LAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2527-2606 |
3.05e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 58.67 E-value: 3.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2527 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNN 2600
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 1907180936 2601 NPISNS 2606
Cdd:TIGR03696 67 NPVNWV 72
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2025-2443 |
5.27e-09 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 62.33 E-value: 5.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2025 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRITSRIFADGKMWSYTyleksmvLHLHSqrqyifefdknDR 2097
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYS-------LNVVS-----------GD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2098 LSSVTMPNVarqtletiRSVGYYRNiyqppegnasviqdfteDGHLLHTFYLGTGRRVIYKYGKLSKL-AETLYDTTKVS 2176
Cdd:NF041261 461 ITDITTPDG--------RETKFYYN-----------------DGNQLTSVTSPDGLESRREYDEPGRLvSETSRSGETTR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2177 FTYDETAGMLKTVNLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR-Y 2255
Cdd:NF041261 516 YRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYRrY 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2256 DD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKKEL 2326
Cdd:NF041261 584 DNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTLTN 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2327 KvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYKMD 2401
Cdd:NF041261 657 E-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQYD 729
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1907180936 2402 EDGFLRQrggdvFEYNSAGLLIkaynrasgwSVRYRYDGLGR 2443
Cdd:NF041261 730 EHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1377-1708 |
5.44e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 5.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1377 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilEMRNKDFRHSHSpahkyyLATDPmSGAVFLSDTNSRRVFKVKST 1453
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIDPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1454 TvvkdlvKNSEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRVD-QNGIISTLLGsn 1530
Cdd:COG4257 89 T------GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1531 DLTSARplscdsvmeisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAIHA 1610
Cdd:COG4257 141 PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1611 TLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLAVC 1690
Cdd:COG4257 186 PGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVAVD 239
|
330
....*....|....*...
gi 1907180936 1691 ADGELYVADLGNIRIRFI 1708
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2253-2589 |
3.29e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 53.08 E-value: 3.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2253 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2314
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2315 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2385
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2386 lrDRITRLGDVqyKMDEDGFLRQrggdvFEYNSAGLLIkAYNRASGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2465
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2466 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2545
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180936 2546 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWKRLSSNSI 2589
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1412-1712 |
1.10e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.39 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1412 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDTNSRRVfkvksttVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1485
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1486 kateATLTNPRGITVDKFGLIYFVDGT---MIRRVD-QNGIISTLLGS----NDLTSARPLScdsvmeiSQVrLEWPTDL 1557
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1558 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1605
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1606 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1657
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1907180936 1658 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1712
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
891-934 |
4.54e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 43.00 E-value: 4.54e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907180936 891 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 934
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1825-1857 |
5.82e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.82e-04
10 20 30
....*....|....*....|....*....|...
gi 1907180936 1825 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1857
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
772-920 |
1.45e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 772 TNQCIDVACSSHGTCimGTCICNPGYKGESCEEVDCMDPTCS----SRGVCVRGECHCSVgwgGTNCETPraTCLDQCS- 846
Cdd:pfam01500 6 TSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCqpttFQSSCCRPTCQPCC---QTSCCQP--TCCQTSSc 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 847 -------GHGTfLPDTGLCNCDPSWTGHDCSIEICAADCGGHGVCVGGTCrCEDGWMGAACdqraCHPRCAEHGTCRDGK 919
Cdd:pfam01500 79 qtgcggiGYGQ-EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC-CQLHHAQASC----CRPSYCGQSCCRPAC 152
|
.
gi 1907180936 920 C 920
Cdd:pfam01500 153 C 153
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1618-1804 |
1.71e-03 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 43.02 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1618 LAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCADGELYV 1697
Cdd:cd14957 23 IAVDSAGNIYVADTGN---NRIQVFTSSGVYSYSIG----------------SGGTG---SGQFNSPYGIAVDSNGNIYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1698 ADLGNIRIRfirknkpFLNTQNMYElsspidqelYLFDTSGkhlytQSLPTGDYLYNFTYTGDGDItHITDNNGNMVNVr 1777
Cdd:cd14957 81 ADTDNNRIQ-------VFNSSGVYQ---------YSIGTGG-----SGDGQFNGPYGIAVDSNGNI-YVADTGNHRIQV- 137
|
170 180
....*....|....*....|....*..
gi 1907180936 1778 RDSTGmplwlvvpdgqVYWVTMGTNSA 1804
Cdd:cd14957 138 FTSSG-----------TFSYSIGSGGT 153
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
780-803 |
3.72e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.72e-03
10 20
....*....|....*....|....*...
gi 1907180936 780 CSSHGTCIMG----TCICNPGYKGESCE 803
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
154-483 |
6.15e-148 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 464.83 E-value: 6.15e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 154 SLT-RRRDAERRYTSSSADSEEGKGP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGTNFTLRELGLGEM 231
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 232 TPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETD--- 308
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNeng 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 309 ---HPSS----------------------------------------------------------------LQNHPRLRT 321
Cdd:pfam06484 161 ppiPPSSsssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppnFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 322 PPPPLPHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPagSAQEPTHAQDNWLLNSNIPLETRnlgkqpfl 401
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQ--STQESVQLQDSWVLNSNVPLETR-------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 402 gtlqdnliemdilsasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFSRPAFNLKKPSKYC 480
Cdd:pfam06484 310 -------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYC 364
|
...
gi 1907180936 481 NWK 483
Cdd:pfam06484 365 SWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1367-1708 |
4.16e-47 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 173.10 E-value: 4.16e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1367 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYY----LATDPmSGA 1436
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1437 VFLSDTNSRRVFKVKSTTVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1514
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1515 RRVDQNGIISTLLGsndlTSARPLSCDSVMeiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1592
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1593 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1672
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 1907180936 1673 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1708
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2830-2907 |
3.30e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.43 E-value: 3.30e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180936 2830 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 2907
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1741-2606 |
1.12e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.97 E-value: 1.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1741 LYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALRSVTTQGHELAMMTY 1820
Cdd:COG3209 191 LATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGAS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1821 HGNSGLLATKSNENGW--TTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQ 1898
Cdd:COG3209 271 GAGLDASTGTGGAGGSnaAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1899 DQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRV 1978
Cdd:COG3209 351 GGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGG 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1979 HNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRI 2058
Cdd:COG3209 431 TATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTT 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2059 TSRIFADgkmWSYTYLEKSMVLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFT 2138
Cdd:COG3209 511 TTTAGAR---GLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGG 587
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2139 EDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTVNLQNEGFTCTIRYRQIGPLIDRQIFRFTE 2218
Cdd:COG3209 588 TATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGT 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2219 EGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKE 2298
Cdd:COG3209 668 GVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2299 VQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSAR 2378
Cdd:COG3209 747 TSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGG 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2379 LTPL-----RYDLRDRITRLgdvqykmdEDGFLRQRGGDVFEYNSAGLLIKAynRASGWSVRYRYDGLGRRVSSKSSHSH 2453
Cdd:COG3209 826 GTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSA--TDPGTTESYTYDANGNLTSRTDGGTT 895
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2454 HLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYTAYGEI 2533
Cdd:COG3209 896 TYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNL 954
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180936 2534 YMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 2606
Cdd:COG3209 955 LAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1372-1708 |
5.08e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 89.69 E-value: 5.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1372 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHkyyLATDPmSGAVFLSDTNSRRVFK 1449
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1450 VKSTTVVKDlvknseVVAGTGDQCLPFDdtrcgdggkateatltNPRGITVDKFGLIYFVDgTM---IRRVDQNGIISTL 1526
Cdd:cd05819 81 FDPDGNFLA------SFGGSGDGDGEFN----------------GPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1527 LGSNDLTSARplscdsvmeisqvrLEWPTDLAINPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGiDHFLL--- 1603
Cdd:cd05819 138 FGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFD--------PD-GNFLTtfg 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1604 SKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfsgdDGYAKDAKLNT 1683
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNR 244
|
330 340
....*....|....*....|....*
gi 1907180936 1684 PSSLAVCADGELYVADLGNIRIRFI 1708
Cdd:cd05819 245 PSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1492-1802 |
2.68e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 84.68 E-value: 2.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1492 LTNPRGITVDKFGLIYFVDGTM--IRRVDQNGIISTLLGSNDltsarplscdsvmeISQVRLEWPTDLAINPmDNSLYVL 1569
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1570 D--NNVVLQISENHQVRIVAGRPmhcqvpGIDHFLLSkvaihatleSATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1647
Cdd:cd05819 72 DtgNHRIQKFDPDGNFLASFGGS------GDGDGEFN---------GPRGIAVDSSGNIYVADTGN---HRIQKFDPDGE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1648 ISLVAGAPSGCDckndancdcfsgddgyakdAKLNTPSSLAVCADGELYVADLGNIRIRFIrknkpflntqnmyelsSPI 1727
Cdd:cd05819 134 FLTTFGSGGSGP-------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVF----------------DPD 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1728 DQELYLFDTSGKHLYTQSLPTG------DYLYnFTYTGDGDITHITDN------NGNmVNVRRDSTGMPLWLVV-PDGQV 1794
Cdd:cd05819 179 GNFLTTFGSTGTGPGQFNYPTGiavdsdGNIY-VADSGNNRVQVFDPDgagfggNGN-FLGSDGQFNRPSGLAVdSDGNL 256
|
....*...
gi 1907180936 1795 YWVTMGTN 1802
Cdd:cd05819 257 YVADTGNN 264
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1364-1577 |
2.71e-14 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 76.80 E-value: 2.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1364 SCNGLADGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNilemrnkdfrhshspahkyylatdpmsgavflsd 1441
Cdd:cd14953 176 AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTT---------------------------------- 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1442 tnsrrvfkvksttvvkdlvknsevVAGTGDQclPFddtrcGDGGKATEATLTNPRGITVDKFGLIYFVD---GTmIRRVD 1518
Cdd:cd14953 222 ------------------------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAGNLYVADsgnHR-IRKIT 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907180936 1519 QNGIISTLLGSndlTSARPLSCDSVmeiSQVRLEWPTDLAINPmDNSLYVLD--NNVVLQI 1577
Cdd:cd14953 270 PAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1370-1639 |
1.85e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 73.12 E-value: 1.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1370 DGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPahkYYLATDPmSGAVFLSDTNSRRV 1447
Cdd:cd05819 50 GDGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGP---RGIAVDS-SGNIYVADTGNHRI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1448 FKVKSttvvkdlvkNSEVVAGTGdqclpfddtrcgdGGKATEATLTNPRGITVDKFGLIYFVD--GTMIRRVDQNGIIST 1525
Cdd:cd05819 126 QKFDP---------DGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADtgNHRIQVFDPDGNFLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1526 LLGSNDLTSArplscdsvmeisqvRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGrpmhcqvpgidhfll 1603
Cdd:cd05819 184 TFGSTGTGPG--------------QFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------- 233
|
250 260 270
....*....|....*....|....*....|....*.
gi 1907180936 1604 SKVAIHATLESATALAVSHNGVLYIAETDEKKINRI 1639
Cdd:cd05819 234 NFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2527-2606 |
3.05e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 58.67 E-value: 3.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2527 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNN 2600
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 1907180936 2601 NPISNS 2606
Cdd:TIGR03696 67 NPVNWV 72
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1428-1705 |
2.53e-09 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 60.68 E-value: 2.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1428 LATDPmSGAVFLSDTNSRRVFKVksttvvkdlvknsevVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLI 1506
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLKL---------------AAGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1507 YFVDGtmirrvDQNGIISTLLGSNDLTsarPLSCDSvmeisqvrLEWPTDLAINPMDNsLYVLD--NNVVLqisenhqvR 1584
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQT---VLPFTG--------LNDPTGVAVDAAGN-VYVADtgNNRVL--------K 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1585 IVAGRPMHCQVPgidhFllskvaihATLESATALAVSHNGVLYIAETDEkkiNRIRQvttsgeisLVAGA------Psgc 1658
Cdd:cd14952 120 LAAGSNTQTVLP----F--------TGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSttqtvlP--- 173
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1907180936 1659 dckndancdcFSGddgyakdakLNTPSSLAVCADGELYVADLGNIRI 1705
Cdd:cd14952 174 ----------FTG---------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2025-2443 |
5.27e-09 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 62.33 E-value: 5.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2025 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRITSRIFADGKMWSYTyleksmvLHLHSqrqyifefdknDR 2097
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYS-------LNVVS-----------GD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2098 LSSVTMPNVarqtletiRSVGYYRNiyqppegnasviqdfteDGHLLHTFYLGTGRRVIYKYGKLSKL-AETLYDTTKVS 2176
Cdd:NF041261 461 ITDITTPDG--------RETKFYYN-----------------DGNQLTSVTSPDGLESRREYDEPGRLvSETSRSGETTR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2177 FTYDETAGMLKTVNLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR-Y 2255
Cdd:NF041261 516 YRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYRrY 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2256 DD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKKEL 2326
Cdd:NF041261 584 DNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTLTN 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2327 KvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYKMD 2401
Cdd:NF041261 657 E-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQYD 729
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1907180936 2402 EDGFLRQrggdvFEYNSAGLLIkaynrasgwSVRYRYDGLGR 2443
Cdd:NF041261 730 EHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1377-1708 |
5.44e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 5.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1377 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilEMRNKDFRHSHSpahkyyLATDPmSGAVFLSDTNSRRVFKVKST 1453
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIDPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1454 TvvkdlvKNSEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRVD-QNGIISTLLGsn 1530
Cdd:COG4257 89 T------GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1531 DLTSARplscdsvmeisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAIHA 1610
Cdd:COG4257 141 PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1611 TLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLAVC 1690
Cdd:COG4257 186 PGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVAVD 239
|
330
....*....|....*...
gi 1907180936 1691 ADGELYVADLGNIRIRFI 1708
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1494-1705 |
8.05e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 53.44 E-value: 8.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1494 NPRGITVDKFGLIYFVD--GTMIRRVDQNGIISTLLGSndlTSARPLScdsvmeisqvrLEWPTDLAINPmDNSLYVLDn 1571
Cdd:cd14956 108 APRGVAVDADGNLYVADfgNQRIQKFDPDGSFLRQWGG---TGIEPGS-----------FNYPRGVAVDP-DGTLYVAD- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1572 nvvlqiSENHQVrivagrpmhcQVPGIDHFLLSKVAIHAT----LESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1647
Cdd:cd14956 172 ------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---NRIQKFTADGT 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180936 1648 ISLVAGAPSGcdckndancdcfsgddgyaKDAKLNTPSSLAVCADGELYVADLGNIRI 1705
Cdd:cd14956 233 FLTSWGSPGT-------------------GPGQFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2253-2589 |
3.29e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 53.08 E-value: 3.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2253 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2314
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2315 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2385
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2386 lrDRITRLGDVqyKMDEDGFLRQrggdvFEYNSAGLLIkAYNRASGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2465
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 2466 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2545
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180936 2546 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWKRLSSNSI 2589
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1490-1708 |
5.71e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 50.79 E-value: 5.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1490 ATLTNPRGITVDKFGLIYFVD--GTMIRRVD-QNGIIStllgsndltsarplscdsvmEISQVRLEWPTDLAINPmDNSL 1566
Cdd:COG4257 14 APGSGPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFT--------------------EYPLGGGSGPHGIAVDP-DGNL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1567 YVLD--NNVVLQIS-ENHQVRIVAGrpmhcqvPGIDHFLlskvaihatlesaTALAVSHNGVLYIAETDekkINRIRQVT 1643
Cdd:COG4257 73 WFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNP-------------HGIAFDPDGNLWFTDQG---GNRIGRLD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1644 T-SGEISLV-----AGAPSGCDCKND---------ANC-DCFSGDDG----YAKDAKLNTPSSLAVCADGELYVADLGNI 1703
Cdd:COG4257 130 PaTGEVTEFplptgGAGPYGIAVDPDgnlwvtdfgANAiGRIDPDTGtlteYALPTPGAGPRGLAVDPDGNLWVADTGSG 209
|
....*
gi 1907180936 1704 RIRFI 1708
Cdd:COG4257 210 RIGRF 214
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1412-1712 |
1.10e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.39 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1412 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDTNSRRVfkvksttVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1485
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1486 kateATLTNPRGITVDKFGLIYFVDGT---MIRRVD-QNGIISTLLGS----NDLTSARPLScdsvmeiSQVrLEWPTDL 1557
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1558 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1605
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1606 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1657
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1907180936 1658 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1712
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1495-1802 |
2.26e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 48.80 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1495 PRGITVDKFGLIYFVD--GTMIRRVDQNGIISTLLGSNDltsarplscdsvmeISQVRLEWPTDLAINPMDNsLYVLDnn 1572
Cdd:cd14957 20 PRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVAD-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1573 vvlqiSENHQVRIvagrpmhcqvpgidhFLLSKVAIHA---------TLESATALAVSHNGVLYIAETDEkkiNRIrQVT 1643
Cdd:cd14957 83 -----TDNNRIQV---------------FNSSGVYQYSigtggsgdgQFNGPYGIAVDSNGNIYVADTGN---HRI-QVF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1644 TSgeislvAGAPsgcdckndancdCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRfirknkpflntqnmyel 1723
Cdd:cd14957 139 TS------SGTF------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ----------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1724 sspidqelyLFDTSGKHLYT-QSLPTGDYLYNFTY----TGDGDItHITDNNGNMVNVrRDSTGmplwlvvpdgqVYWVT 1798
Cdd:cd14957 184 ---------VFTSSGTFQYTfGSSGSGPGQFSDPYgiavDSDGNI-YVADTGNHRIQV-FTSSG-----------AYQYS 241
|
....
gi 1907180936 1799 MGTN 1802
Cdd:cd14957 242 IGTS 245
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1484-1705 |
4.20e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 48.05 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1484 GGKATEA-TLTNPRGITVDKFGLIYFVDGT--MIRRVDQNGIISTLLGSNdltSARPLSCDSvmeisqvrlewPTDLAIN 1560
Cdd:cd14956 50 GTTGDGPgQFGRPRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSS---GSGPGQFNA-----------PRGVAVD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1561 PmDNSLYVLD--NNVVLQISENHQ-VRIVAGRPmhcQVPGidHFLlskvaihatleSATALAVSHNGVLYIAETdekKIN 1637
Cdd:cd14956 116 A-DGNLYVADfgNQRIQKFDPDGSfLRQWGGTG---IEPG--SFN-----------YPRGVAVDPDGTLYVADT---YND 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180936 1638 RIRQVTTSGEISLVAGAPSGcdckndancdcFSGDdgyakdakLNTPSSLAVCADGELYVADLGNIRI 1705
Cdd:cd14956 176 RIQVFDNDGAFLRKWGGRGT-----------GPGQ--------FNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
891-934 |
4.54e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 43.00 E-value: 4.54e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907180936 891 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 934
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1648-1708 |
6.82e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.91 E-value: 6.82e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907180936 1648 ISLVAGAPSGcdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1708
Cdd:cd14953 1 VSTVAGSGTA------------GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKI 49
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1377-1518 |
7.15e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.32 E-value: 7.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1377 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRhshsPahkYYLATDPmSGAVFLSDTNSRRVFKVKSTT 1454
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFgaNAIGRIDPDTGTLTEYALPTPGAG----P---RGLAVDP-DGNLWVADTGSGRIGRFDPKT 218
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1455 vvkdlvknsevvagtgdqclpfddtrcgdgGKATEATLTN----PRGITVDKFGLIYFVDGT--MIRRVD 1518
Cdd:COG4257 219 ------------------------------GTVTEYPLPGggarPYGVAVDGDGRVWFAESGanRIVRFD 258
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1821-1861 |
2.65e-04 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 40.65 E-value: 2.65e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1907180936 1821 HGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSF 1861
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1619-1709 |
3.45e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 45.65 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1619 AVSHNGVLYIAETdekKINRIRQV-TTSGEISLVAGapsgcdckndancdcfSGDDGYA-KDAKLNTPSSLAVCADGELY 1696
Cdd:cd14951 202 AALPDGSVYVADT---YNHKIKRVdPATGEVSTLAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLY 262
|
90
....*....|...
gi 1907180936 1697 VADLGNIRIRFIR 1709
Cdd:cd14951 263 VADTNNHRIRRLD 275
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1825-1857 |
5.82e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.82e-04
10 20 30
....*....|....*....|....*....|...
gi 1907180936 1825 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1857
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1373-1631 |
1.35e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.43 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1373 KLLAPVALTCGSDGSLYVGDFnYIRRI--F-PSGNVTNILEmRNKDFRHSHSPAHkyyLATDpmSGAVFLSDTNSRRVfk 1449
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKV-- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1450 vksttVVKDLvknsevvagTGDQCLPFddtrcGDGGKAtEATLTNPRGITVDKFGLIYFVDgTMIRRV---DQNG-IIST 1525
Cdd:cd14963 125 -----IVFDL---------EGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVAD-SGNGRIqvfDKNGkFIKE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1526 LLGSNDLTSArplscdsvmeisqvrLEWPTDLAINPmDNSLYVLDN--NVVLQISENHQVRIVAGRpmhcqvPGIDhfll 1603
Cdd:cd14963 184 LNGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD---- 237
|
250 260
....*....|....*....|....*...
gi 1907180936 1604 skvaiHATLESATALAVSHNGVLYIAET 1631
Cdd:cd14963 238 -----DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
772-920 |
1.45e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 772 TNQCIDVACSSHGTCimGTCICNPGYKGESCEEVDCMDPTCS----SRGVCVRGECHCSVgwgGTNCETPraTCLDQCS- 846
Cdd:pfam01500 6 TSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCqpttFQSSCCRPTCQPCC---QTSCCQP--TCCQTSSc 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 847 -------GHGTfLPDTGLCNCDPSWTGHDCSIEICAADCGGHGVCVGGTCrCEDGWMGAACdqraCHPRCAEHGTCRDGK 919
Cdd:pfam01500 79 qtgcggiGYGQ-EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC-CQLHHAQASC----CRPSYCGQSCCRPAC 152
|
.
gi 1907180936 920 C 920
Cdd:pfam01500 153 C 153
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1618-1804 |
1.71e-03 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 43.02 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1618 LAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCADGELYV 1697
Cdd:cd14957 23 IAVDSAGNIYVADTGN---NRIQVFTSSGVYSYSIG----------------SGGTG---SGQFNSPYGIAVDSNGNIYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1698 ADLGNIRIRfirknkpFLNTQNMYElsspidqelYLFDTSGkhlytQSLPTGDYLYNFTYTGDGDItHITDNNGNMVNVr 1777
Cdd:cd14957 81 ADTDNNRIQ-------VFNSSGVYQ---------YSIGTGG-----SGDGQFNGPYGIAVDSNGNI-YVADTGNHRIQV- 137
|
170 180
....*....|....*....|....*..
gi 1907180936 1778 RDSTGmplwlvvpdgqVYWVTMGTNSA 1804
Cdd:cd14957 138 FTSSG-----------TFSYSIGSGGT 153
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1372-1456 |
2.13e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 42.70 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1372 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTNilemrnkdFRHSHSPAHKYYLATDPmSGAVFLSDTNSRRVF 1448
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
....*...
gi 1907180936 1449 KVKSTTVV 1456
Cdd:COG4257 256 RFDPDTEL 263
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
909-931 |
3.41e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 3.41e-03
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1485-1587 |
3.71e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 42.18 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1485 GKATEATLTNPRGITVDKFGLIYFVDgTM---IRRVD-QNGIISTLLGSNDLTSArplscdsvmeISQVRLEWPTDLAIN 1560
Cdd:cd14951 188 GPGAEALLQHPLGVAALPDGSVYVAD-TYnhkIKRVDpATGEVSTLAGTGKAGYK----------DLEAQFSEPSGLVVD 256
|
90 100
....*....|....*....|....*..
gi 1907180936 1561 PmDNSLYVLDNNvvlqiseNHQVRIVA 1587
Cdd:cd14951 257 G-DGRLYVADTN-------NHRIRRLD 275
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
780-803 |
3.72e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.72e-03
10 20
....*....|....*....|....*...
gi 1907180936 780 CSSHGTCIMG----TCICNPGYKGESCE 803
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
779-802 |
5.68e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 5.68e-03
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1377-1578 |
6.34e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.04 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1377 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILemrnkDFRHSHSPahkYYLATDPmSGAVFLSDTNSRRVFKVkstt 1454
Cdd:cd14952 96 PTGVAVDAAGNVYVADTgnNRVLKLAAGSNTQTVL-----PFTGLSNP---DGVAVDG-AGNVYVTDTGNNRVLKL---- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180936 1455 vvkdlvknsevVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLIYFVDGtmirrvDQNGIISTLLGSNDLT 1533
Cdd:cd14952 163 -----------AAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYVTDH------GNNRVLKLAAGSTTPT 212
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1907180936 1534 sARPLScdsvmeisqvRLEWPTDLAINPmDNSLYVLD--NNVVLQIS 1578
Cdd:cd14952 213 -VLPFT----------GLNGPLGVAVDA-AGNVYVADrgNDRVVKLP 247
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
2416-2445 |
9.15e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 9.15e-03
10 20 30
....*....|....*....|....*....|
gi 1907180936 2416 YNSAGLLIKAYNrASGWSVRYRYDGLGRRV 2445
Cdd:pfam05593 1 YDAAGRLTSVTD-PDGRVTTYTYDAAGRLT 29
|
|
| |
