battenin isoform X3 [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| CLN3 super family | cl47738 | CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of ... |
29-222 | 1.30e-67 | ||||
CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterized by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localized to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localization of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2. The actual alignment was detected with superfamily member pfam02487: Pssm-ID: 460570 Cd Length: 383 Bit Score: 212.37 E-value: 1.30e-67
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| Name | Accession | Description | Interval | E-value | ||||
| CLN3 | pfam02487 | CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of ... |
29-222 | 1.30e-67 | ||||
CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterized by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localized to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localization of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2. Pssm-ID: 460570 Cd Length: 383 Bit Score: 212.37 E-value: 1.30e-67
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| Name | Accession | Description | Interval | E-value | ||||
| CLN3 | pfam02487 | CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of ... |
29-222 | 1.30e-67 | ||||
CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterized by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localized to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localization of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2. Pssm-ID: 460570 Cd Length: 383 Bit Score: 212.37 E-value: 1.30e-67
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| Blast search parameters | ||||
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