Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 350 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 429
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1825819917 430 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 470
Cdd:cd08721    81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1825819917 585 AMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQYDQPLEKSTKV 629
Cdd:cd12804     1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 350 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 429
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1825819917 430 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 470
Cdd:cd08721    81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917  347 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSqlaakkgQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 426
Cdd:smart00315   2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1825819917  427 EIESNICrEGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 471
Cdd:smart00315  75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 347 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 426
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEF-------KKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1825819917 427 EIESNICREggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 471
Cdd:pfam00615  75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 350 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 429
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1825819917 430 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 470
Cdd:cd08721    81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917  347 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSqlaakkgQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 426
Cdd:smart00315   2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1825819917  427 EIESNICrEGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 471
Cdd:smart00315  75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1825819917 585 AMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQYDQPLEKSTKV 629
Cdd:cd12804     1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 130 LHDTVVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNtvkqsslaepvspskkHETTAAFLTDSLDKRLed 209
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDEELKSKA----------------KEIYDKYISKDAPKEI-- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 210 sssaqffmthsegidlnnrtnstqnhlllsqeydsahslhleraragthqvsmetqessstltvaskNSPASPLKELSGK 289
Cdd:cd07440    63 -------------------------------------------------------------------NIPESIREEIEEN 75

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1825819917 290 LmktkicgEDGQVDPNCFILAQSIVFSAMEQEHFSEFLRSHHFCK 334
Cdd:cd07440    76 L-------EEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1825819917 564 FIRESEPEPDvkKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMI 609
Cdd:cd12804     2 FKKWVQPEPD--EAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 350 ILFCESALFYFSEYMEKEDAVNILQFWLAADNF----QSQL-AAKKGQYDGQEAQNDAM--------ILYDKYFSLQATH 416
Cdd:cd08719     1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYrvsaEQQLsELHLRQRGGEHQRSDVYemlraaalNIYDQYLSEKASP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1825819917 417 PLGFDDVVRLEIESNIcREGGPLPNCFTTPLRQAWTTMEK--VFLPGFLSSNLYYK 470
Cdd:cd08719    81 RVPLDDSLVKKLLNRL-RNDTPSDLWFDDIQQKVFDIMQEdeRFYPAFKKSPAYVK 135

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 359 YFSEYMEKE-DAVNILqFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIEsnICREgg 437
Cdd:cd08706    13 YFTEFLKKEfSEENIL-FWQACEKF-------KKIPDKKQLVQEAREIYDTFLSSKASSPVNIDSQAQLAEE--MLEE-- 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1825819917 438 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08706    81 PHPDMFQKQQLQIFNLMKFDSYSRFLKSPLY 111

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 356 ALFYFSEYMEKEDAVNILQFWLAADNFQsQLAAKKGQYDGQEAQNdamiLYDKYFSLQATHPLGFDDvvRLEIESNICRE 435
Cdd:cd08743    20 GVEYFTEFLKKEFSAENVNFWKACERFQ-QIPASDTQQLAQEARK----IYNEFLSSSSQSPVNIDQ--QAWIGEDMLAT 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1825819917 436 ggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08743    93 --PSPDMFRAQQLQIFNLMKFDSYARFVKSPLY 123

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 360 FSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEaqndamiLYDKYFSLQATHPLGFDDVVRLEIESNICReggPL 439
Cdd:cd08716    14 YATYLKTEHSDENIEFWLACETYKKIASQRKRISMARK-------LFASYIQPQAPREINIDSPTRKAIIRNIQE---PT 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1825819917 440 PNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 470
Cdd:cd08716    84 QSCFDEAQRIVYMHMERDSYPRFLESKFYQK 114

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 358 FYFSEYMEKedavNIlQFWLAADNFQSQLAAKKGQydgQEAQNdamiLYDKYFSLQATHPLGFDDVVRLEIESNICRegg 437
Cdd:cd08714    17 FLKSEYSEE----NI-DFWVSCEDYKKTKSPSKLS---PKARK----IYEEFISVQATKEVNLDSCTREETSRNMLE--- 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1825819917 438 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08714    82 PTISCFDEAQKKIFTLMEKDSYRRFLKSRFY 112

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 360 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICregGPL 439
Cdd:cd08744    18 FREFLRTEYSEENLLFWLACEDL-------KKEQNKKVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNLL---DPN 87

                          90       100
                  ....*....|....*....|....*....
gi 1825819917 440 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08744    88 PHMYEDAQLQIYTLMHRDSFPRFLNSQIY 116

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 360 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICReggPL 439
Cdd:cd08745    18 FREFLRTEYSEENMLFWLACEEL-------KAEANKHVIDEKARLIYEDYISILSPKEVSLDSRVREGINRKMQE---PS 87

                          90       100
                  ....*....|....*....|....*....
gi 1825819917 440 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08745    88 SHTFDDAQLQIYTLMHRDSYPRFLNSPIY 116

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 350 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQlaAKKGQydgqeAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 429
Cdd:cd08746    57 LMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKE--ANKSV-----IEEKARIIYEDYISILSPKEVSLDSRVREVIN 129

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1825819917 430 SNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08746   130 RNMLE---PSQHTFDDAQLQIYTLMHRDSYPRFMNSAIY 165

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 359 YFSEYMEKEDAVNILQFWLAADNFQSQLAakkgqYDGQEAQNDAMILYDKYFSLQATHPLGFDDvvRLEIESNICRegGP 438
Cdd:cd08742    13 YFSEFLRKEFSEENILFWQACEYFNHVPA-----HDKKELSYRAREIFSKFLCSKATTPVNIDS--QAQLADDILN--AP 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1825819917 439 LPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 468
Cdd:cd08742    84 HPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 113

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825819917 359 YFSEYMEKEDAVNILQFWLAADNFQSqlaAKKGQYDgqeaQNDAMILYDkyFSLQATHPLGFDDVVRLEIESNICREGGp 438
Cdd:cd08720    10 YLSQFLERMDSQALIGFWEAVEELRS---ANKSEWH----QLGAEIFYT--FIVEPTAEIKVDKSLRKRIEQFLLGDKG- 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1825819917 439 lPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 470
Cdd:cd08720    80 -PEVFYEVQENVVETLEEKYYPSFVVSDQYKQ 110